SIMILAR PATTERNS OF AMINO ACIDS FOR 4W5N_A_IPHA901

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 VAL A 957
ALA A 962
PHE A1048
 None
 0.91A 4w5nA-1c30A:
2.2		 4w5nA-1c30A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dt2 EXFOLIATIVE TOXIN B

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		3 VAL A  39
ALA A  82
PHE A  79
 None
 0.84A 4w5nA-1dt2A:
0.0		 4w5nA-1dt2A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eep INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00478
(IMPDH) 		3 VAL A 271
ALA A 261
PHE A  12
 None
 0.88A 4w5nA-1eepA:
0.0		 4w5nA-1eepA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		3 VAL A  62
ALA A  86
PHE A  38
 None
 0.87A 4w5nA-1fp3A:
undetectable		 4w5nA-1fp3A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0u PROTEASOME COMPONENT
PUP2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 VAL D  68
ALA D  77
PHE D 221
 None
 0.78A 4w5nA-1g0uD:
0.0		 4w5nA-1g0uD:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy8 UDP-GALACTOSE
4-EPIMERASE

(Trypanosoma
brucei) 		PF01370
(Epimerase) 		3 VAL A 343
ALA A 345
PHE A 201
 None
 0.81A 4w5nA-1gy8A:
3.7		 4w5nA-1gy8A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h39 SQUALENE--HOPENE
CYCLASE

(Alicyclobacillus
acidocaldarius) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 VAL A 382
ALA A 399
PHE A 363
 None
 0.78A 4w5nA-1h39A:
undetectable		 4w5nA-1h39A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		3 VAL A 285
ALA A 130
PHE A 237
 None
 0.90A 4w5nA-1h79A:
3.1		 4w5nA-1h79A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jal YCHF PROTEIN

(Haemophilus
influenzae) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		3 VAL A  13
ALA A 238
PHE A 107
 None
 0.92A 4w5nA-1jalA:
5.4		 4w5nA-1jalA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwe PROTEIN (DNAB
HELICASE)

(Escherichia
coli) 		PF00772
(DnaB) 		3 VAL A  55
ALA A  51
PHE A  68
 None
 0.92A 4w5nA-1jweA:
undetectable		 4w5nA-1jweA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 VAL A 228
ALA A 300
PHE A 216
 None
 0.92A 4w5nA-1lamA:
2.3		 4w5nA-1lamA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 VAL A 402
ALA A 423
PHE A 386
 None
 0.93A 4w5nA-1lpfA:
undetectable		 4w5nA-1lpfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 VAL B 212
ALA B 708
PHE B 731
 None
 0.90A 4w5nA-1n60B:
undetectable		 4w5nA-1n60B:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npy HYPOTHETICAL
SHIKIMATE
5-DEHYDROGENASE-LIKE
PROTEIN HI0607

(Haemophilus
influenzae) 		PF08501
(Shikimate_dh_N) 		3 VAL A 240
ALA A 263
PHE A  19
 None
 0.73A 4w5nA-1npyA:
undetectable		 4w5nA-1npyA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 VAL A 121
ALA A 149
PHE A 102
 None
 0.74A 4w5nA-1nr0A:
undetectable		 4w5nA-1nr0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oll NK RECEPTOR

(Homo sapiens) 		no annotation 3 VAL A 147
ALA A 125
PHE A 129
 None
 0.85A 4w5nA-1ollA:
undetectable		 4w5nA-1ollA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox4 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
HISHF

(Saccharomyces
cerevisiae) 		PF00117
(GATase)
PF00977
(His_biosynth) 		3 VAL B 182
ALA B 180
PHE B 134
 None
 0.91A 4w5nA-1ox4B:
2.9		 4w5nA-1ox4B:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvm CONSERVED
HYPOTHETICAL PROTEIN
TA0289

(Thermoplasma
acidophilum) 		PF00571
(CBS)
PF09151
(DUF1936) 		3 VAL A 113
ALA A 104
PHE A  13
 None
 0.90A 4w5nA-1pvmA:
undetectable		 4w5nA-1pvmA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj7 ECTODYSPLASIN A

(Homo sapiens) 		PF00229
(TNF) 		3 VAL A 351
ALA A 349
PHE A 329
 None
 0.89A 4w5nA-1rj7A:
undetectable		 4w5nA-1rj7A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry4 CG5884-PA

(Drosophila
melanogaster) 		PF00595
(PDZ) 		3 VAL A 145
ALA A 147
PHE A 142
 None
 0.88A 4w5nA-1ry4A:
undetectable		 4w5nA-1ry4A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1slq VP4

(Rotavirus A) 		PF17477
(Rota_VP4_MID)
PF17478
(VP4_helical) 		3 VAL A 344
ALA A 453
PHE A 296
 None
 0.90A 4w5nA-1slqA:
undetectable		 4w5nA-1slqA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		3 VAL A 139
ALA A 108
PHE A 156
 None
 0.77A 4w5nA-1smlA:
undetectable		 4w5nA-1smlA:
15.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Zea mays) 		PF00903
(Glyoxalase) 		3 VAL A 299
ALA A 134
PHE A 290
 None
 0.61A 4w5nA-1sp8A:
undetectable		 4w5nA-1sp8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 95 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08519
(RFC1) 		3 VAL A 317
ALA A 363
PHE A 475
 None
 0.88A 4w5nA-1sxjA:
undetectable		 4w5nA-1sxjA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 VAL A 126
ALA A 141
PHE A 122
 None
 0.88A 4w5nA-1t8hA:
undetectable		 4w5nA-1t8hA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 VAL A 104
ALA A 148
PHE A 288
 SF4  A 491 ( 4.7A)
None
None
 0.86A 4w5nA-1u8vA:
undetectable		 4w5nA-1u8vA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		3 VAL A  83
ALA A  92
PHE A  50
 None
None
MET  A1298 (-3.8A)
 0.89A 4w5nA-1wkmA:
undetectable		 4w5nA-1wkmA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3j COPPER-TRANSPORTING
ATPASE 1

(Homo sapiens) 		PF00403
(HMA) 		3 VAL A  18
ALA A  43
PHE A  66
 None
 0.93A 4w5nA-1y3jA:
2.7		 4w5nA-1y3jA:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 VAL A 170
ALA A 197
PHE A 386
 None
 0.89A 4w5nA-1ykwA:
undetectable		 4w5nA-1ykwA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzp PEROXIDASE
MANGANESE-DEPENDENT
I

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		3 VAL A 137
ALA A 135
PHE A  77
 None
 0.66A 4w5nA-1yzpA:
undetectable		 4w5nA-1yzpA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zoi ESTERASE

(Pseudomonas
putida) 		PF00561
(Abhydrolase_1) 		3 VAL A 219
ALA A 247
PHE A 273
 None
 0.87A 4w5nA-1zoiA:
2.8		 4w5nA-1zoiA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		3 VAL A 285
ALA A 280
PHE A 148
 None
 0.93A 4w5nA-2bbvA:
undetectable		 4w5nA-2bbvA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmm PROTEIN
DISULFIDE-ISOMERASE
A3

(Homo sapiens) 		PF00085
(Thioredoxin) 		3 VAL A  48
ALA A 109
PHE A 106
 None
 0.71A 4w5nA-2dmmA:
undetectable		 4w5nA-2dmmA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		3 VAL A 124
ALA A 122
PHE A 350
 None
 0.94A 4w5nA-2e3jA:
undetectable		 4w5nA-2e3jA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e67 HYPOTHETICAL PROTEIN
TTHB029

(Thermus
thermophilus) 		PF04794
(YdjC) 		3 VAL A  59
ALA A 114
PHE A 119
 None
 0.86A 4w5nA-2e67A:
undetectable		 4w5nA-2e67A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		3 VAL A 214
ALA A 212
PHE A 360
 None
 0.71A 4w5nA-2e7uA:
2.6		 4w5nA-2e7uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		3 VAL A 218
ALA A 216
PHE A 364
 None
 0.69A 4w5nA-2epjA:
2.4		 4w5nA-2epjA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fom POLYPROTEIN

(Dengue virus) 		PF00949
(Peptidase_S7) 		3 VAL B  40
ALA B  38
PHE B  46
 None
 0.83A 4w5nA-2fomB:
undetectable		 4w5nA-2fomB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		3 VAL B  40
ALA B  38
PHE B  46
 None
 0.81A 4w5nA-2fp7B:
undetectable		 4w5nA-2fp7B:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvm DIHYDROPYRIMIDINASE

(Lachancea
kluyveri) 		PF01979
(Amidohydro_1) 		3 VAL A  63
ALA A  61
PHE A  97
 None
None
KCX  A 167 ( 4.5A)
 0.94A 4w5nA-2fvmA:
undetectable		 4w5nA-2fvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggv NON-STRUCTURAL
PROTEIN 3

(West Nile virus) 		PF00949
(Peptidase_S7) 		3 VAL B  40
ALA B  38
PHE B  46
 None
 0.89A 4w5nA-2ggvB:
undetectable		 4w5nA-2ggvB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh9 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		3 VAL A 273
ALA A 275
PHE A  46
 None
 0.91A 4w5nA-2gh9A:
undetectable		 4w5nA-2gh9A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8a MICROSOMAL
GLUTATHIONE
S-TRANSFERASE 1

(Rattus
norvegicus) 		PF01124
(MAPEG) 		3 VAL A 110
ALA A 112
PHE A  85
 None
 0.91A 4w5nA-2h8aA:
undetectable		 4w5nA-2h8aA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i8l HYDROGENASE 3
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		3 VAL A  61
ALA A  63
PHE A 110
 None
 0.91A 4w5nA-2i8lA:
undetectable		 4w5nA-2i8lA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		3 VAL A 334
ALA A 505
PHE A 389
 None
 0.89A 4w5nA-2jgpA:
undetectable		 4w5nA-2jgpA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		3 VAL A   8
ALA A  10
PHE A  23
 None
 0.78A 4w5nA-2lbpA:
4.3		 4w5nA-2lbpA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2liv LEUCINE

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		3 VAL A   8
ALA A  10
PHE A  23
 None
 0.66A 4w5nA-2livA:
4.7		 4w5nA-2livA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2msx KUNITZ-TYPE PROTEASE
INHIBITOR 1

(Homo sapiens) 		PF07502
(MANEC) 		3 VAL A 102
ALA A 114
PHE A 117
 None
 0.82A 4w5nA-2msxA:
undetectable		 4w5nA-2msxA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owz FRUCTOSE-1,6-BISPHOS
PHATASE

(Escherichia
coli) 		PF00316
(FBPase) 		3 VAL A 107
ALA A  84
PHE A 146
 None
 0.94A 4w5nA-2owzA:
undetectable		 4w5nA-2owzA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozg GCN5-RELATED
N-ACETYLTRANSFERASE

(Trichormus
variabilis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		3 VAL A  84
ALA A  82
PHE A  30
 COA  A 500 (-3.8A)
None
COA  A 500 ( 4.5A)
 0.92A 4w5nA-2ozgA:
undetectable		 4w5nA-2ozgA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 VAL A 922
ALA A 867
PHE A 850
 None
 0.83A 4w5nA-2pffA:
undetectable		 4w5nA-2pffA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		3 VAL A 115
ALA A 425
PHE A   7
 None
 0.90A 4w5nA-2q01A:
undetectable		 4w5nA-2q01A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		3 VAL A 173
ALA A 171
PHE A 211
 None
 0.82A 4w5nA-2rfaA:
undetectable		 4w5nA-2rfaA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgt FUSION OF
LIM/HOMEOBOX PROTEIN
LHX3, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-1

(Mus musculus;
synthetic
construct) 		PF00412
(LIM) 		3 VAL A 266
ALA A 268
PHE A 134
 None
 0.94A 4w5nA-2rgtA:
undetectable		 4w5nA-2rgtA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 VAL B  67
ALA B  69
PHE B 173
 None
 0.87A 4w5nA-2v4jB:
2.5		 4w5nA-2v4jB:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5o CATION-INDEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Homo sapiens) 		PF00040
(fn2)
PF00878
(CIMR) 		3 VAL A2067
ALA A2124
PHE A1996
 None
 0.92A 4w5nA-2v5oA:
undetectable		 4w5nA-2v5oA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vri NON-STRUCTURAL
PROTEIN 3

(Human
coronavirus
NL63) 		PF01661
(Macro) 		3 VAL A  74
ALA A  72
PHE A  84
 None
 0.92A 4w5nA-2vriA:
2.7		 4w5nA-2vriA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vw8 PA1000

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		3 VAL A 164
ALA A  92
PHE A 166
 None
 0.94A 4w5nA-2vw8A:
undetectable		 4w5nA-2vw8A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wxu PHOSPHOLIPASE C

(Clostridium
perfringens) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 VAL A 140
ALA A 142
PHE A  69
 None
 0.91A 4w5nA-2wxuA:
undetectable		 4w5nA-2wxuA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmz HYDROLASE,
ALPHA/BETA HYDROLASE
FOLD FAMILY

(Staphylococcus
aureus) 		PF00561
(Abhydrolase_1) 		3 VAL A  43
ALA A   9
PHE A   6
 None
 0.82A 4w5nA-2xmzA:
2.2		 4w5nA-2xmzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		3 VAL A 163
ALA A 270
PHE A 319
 None
 0.89A 4w5nA-2xqyA:
undetectable		 4w5nA-2xqyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		3 VAL A 205
ALA A 235
PHE A 232
 None
 0.49A 4w5nA-2yp1A:
undetectable		 4w5nA-2yp1A:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzw ADP-RIBOSYLGLYCOHYDR
OLASE

(Thermus
thermophilus) 		PF03747
(ADP_ribosyl_GH) 		3 VAL A 206
ALA A 189
PHE A 210
 None
 0.80A 4w5nA-2yzwA:
undetectable		 4w5nA-2yzwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		3 VAL A 751
ALA A 500
PHE A 518
 None
 0.92A 4w5nA-2znsA:
undetectable		 4w5nA-2znsA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		3 VAL A  29
ALA A  37
PHE A 137
 None
 0.86A 4w5nA-3aq0A:
undetectable		 4w5nA-3aq0A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdv UNCHARACTERIZED
PROTEIN DUF1234

(Pectobacterium
atrosepticum) 		PF06821
(Ser_hydrolase) 		3 VAL A 101
ALA A  99
PHE A 182
 None
 0.82A 4w5nA-3bdvA:
5.3		 4w5nA-3bdvA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		3 VAL A 831
ALA A 798
PHE A 598
 None
 0.76A 4w5nA-3bg9A:
undetectable		 4w5nA-3bg9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6g CYTOCHROME P450 2R1

(Homo sapiens) 		PF00067
(p450) 		3 VAL A 364
ALA A 322
PHE A 420
 None
 0.92A 4w5nA-3c6gA:
undetectable		 4w5nA-3c6gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ds8 LIN2722 PROTEIN

(Listeria
innocua) 		PF06028
(DUF915) 		3 VAL A 174
ALA A 209
PHE A 238
 None
 0.94A 4w5nA-3ds8A:
2.3		 4w5nA-3ds8A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6q LIM AND SENESCENT
CELL
ANTIGEN-LIKE-CONTAIN
ING DOMAIN PROTEIN 1

(Homo sapiens) 		PF00412
(LIM) 		3 VAL B  37
ALA B  39
PHE B  45
 None
 0.86A 4w5nA-3f6qB:
undetectable		 4w5nA-3f6qB:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 VAL A  38
ALA A 197
PHE A 102
 FES  A 909 ( 3.7A)
None
None
 0.92A 4w5nA-3fahA:
undetectable		 4w5nA-3fahA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fid PUTATIVE OUTER
MEMBRANE PROTEIN
(LPXR)

(Salmonella
enterica) 		PF09982
(DUF2219) 		3 VAL A 223
ALA A 183
PHE A 199
 CXE  A 307 (-4.3A)
CXE  A 306 ( 4.4A)
None
 0.85A 4w5nA-3fidA:
undetectable		 4w5nA-3fidA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 VAL A 241
ALA A  25
PHE A  30
 None
 0.94A 4w5nA-3g7sA:
2.5		 4w5nA-3g7sA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Escherichia
coli) 		PF00936
(BMC) 		3 VAL A 152
ALA A 188
PHE A 204
 None
 0.75A 4w5nA-3gfhA:
undetectable		 4w5nA-3gfhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 VAL A  71
ALA A  45
PHE A 118
 None
 0.91A 4w5nA-3h9uA:
undetectable		 4w5nA-3h9uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9u ADENOSYLHOMOCYSTEINA
SE

(Trypanosoma
brucei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		3 VAL A  71
ALA A  48
PHE A 118
 None
 0.88A 4w5nA-3h9uA:
undetectable		 4w5nA-3h9uA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 VAL A   8
ALA A  36
PHE A  75
 None
NAP  A 366 (-3.4A)
None
 0.94A 4w5nA-3hskA:
2.7		 4w5nA-3hskA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isr TRANSGLUTAMINASE-LIK
E ENZYMES, PUTATIVE
CYSTEINE PROTEASE

(Cytophaga
hutchinsonii) 		PF01841
(Transglut_core) 		3 VAL A 169
ALA A 167
PHE A 173
 None
 0.92A 4w5nA-3isrA:
undetectable		 4w5nA-3isrA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixe LIM AND SENESCENT
CELL
ANTIGEN-LIKE-CONTAIN
ING DOMAIN PROTEIN 2

(Homo sapiens) 		PF00412
(LIM) 		3 VAL B  37
ALA B  39
PHE B  45
 None
 0.94A 4w5nA-3ixeB:
undetectable		 4w5nA-3ixeB:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixl ARYLMALONATE
DECARBOXYLASE

(Bordetella
bronchiseptica) 		no annotation 3 VAL A  20
ALA A  25
PHE A 216
 None
 0.92A 4w5nA-3ixlA:
5.8		 4w5nA-3ixlA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jav INOSITOL
1,4,5-TRISPHOSPHATE
RECEPTOR TYPE 1

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF01365
(RYDR_ITPR)
PF02815
(MIR)
PF08454
(RIH_assoc)
PF08709
(Ins145_P3_rec) 		3 VAL A 433
ALA A 272
PHE A 243
 None
 0.90A 4w5nA-3javA:
undetectable		 4w5nA-3javA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyn QUINONE
OXIDOREDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 VAL A 107
ALA A 104
PHE A  79
 None
 0.79A 4w5nA-3jynA:
undetectable		 4w5nA-3jynA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		3 VAL A 354
ALA A 309
PHE A 298
 None
 0.70A 4w5nA-3jzdA:
3.1		 4w5nA-3jzdA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kby PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10804
(DUF2538) 		3 VAL A  25
ALA A 125
PHE A  23
 None
 0.93A 4w5nA-3kbyA:
undetectable		 4w5nA-3kbyA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgb TEG12

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		3 VAL A  85
ALA A  83
PHE A 184
 None
 0.90A 4w5nA-3mgbA:
3.4		 4w5nA-3mgbA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgx PUTATIVE P450
MONOOXYGENASE

(Amycolatopsis
balhimycina) 		PF00067
(p450) 		3 VAL A 271
ALA A 247
PHE A 326
 None
 0.88A 4w5nA-3mgxA:
undetectable		 4w5nA-3mgxA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nib TEG14

(uncultured soil
bacterium) 		PF00685
(Sulfotransfer_1) 		3 VAL A  85
ALA A  83
PHE A 182
 None
 0.90A 4w5nA-3nibA:
3.6		 4w5nA-3nibA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o31 THERMONICOTIANAMINE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF03059
(NAS) 		3 VAL A 194
ALA A 196
PHE A 128
 None
3O3  A   1 (-3.4A)
BR  A 298 ( 4.8A)
 0.91A 4w5nA-3o31A:
undetectable		 4w5nA-3o31A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		3 VAL A  58
ALA A  31
PHE A  82
 None
 0.91A 4w5nA-3pk0A:
2.5		 4w5nA-3pk0A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		3 VAL A1499
ALA A1602
PHE A1552
 None
NA  A   1 ( 3.9A)
None
 0.69A 4w5nA-3ppxA:
5.4		 4w5nA-3ppxA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q75 FARNESYLTRANSFERASE
BETA SUBUNIT

(Cryptococcus
neoformans) 		PF00432
(Prenyltrans) 		3 VAL B 302
ALA B 334
PHE B 314
 None
 0.83A 4w5nA-3q75B:
undetectable		 4w5nA-3q75B:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		3 VAL A 735
ALA A 484
PHE A 502
 None
 0.88A 4w5nA-3qxmA:
undetectable		 4w5nA-3qxmA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sf6 GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A  88
ALA A 314
PHE A 259
 None
 0.69A 4w5nA-3sf6A:
undetectable		 4w5nA-3sf6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sse 5-METHYLCYTOSINE-SPE
CIFIC RESTRICTION
ENZYME B

(Escherichia
coli) 		PF12102
(DUF3578) 		3 VAL A  77
ALA A 123
PHE A 137
 None
 0.92A 4w5nA-3sseA:
undetectable		 4w5nA-3sseA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swo GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 VAL A  85
ALA A 311
PHE A 256
 None
 0.64A 4w5nA-3swoA:
undetectable		 4w5nA-3swoA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uem PROTEIN
DISULFIDE-ISOMERASE

(Homo sapiens) 		PF00085
(Thioredoxin)
PF13848
(Thioredoxin_6) 		3 VAL A 388
ALA A 448
PHE A 445
 None
 0.71A 4w5nA-3uemA:
undetectable		 4w5nA-3uemA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		3 VAL A  79
ALA A  77
PHE A 167
 None
 0.93A 4w5nA-3uetA:
2.7		 4w5nA-3uetA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		3 VAL A 205
ALA A 203
PHE A  22
 VAL  A 205 ( 0.6A)
ALA  A 203 ( 0.0A)
PHE  A  22 ( 1.3A)
 0.85A 4w5nA-3ulkA:
undetectable		 4w5nA-3ulkA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urh DIHYDROLIPOYL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 VAL A 399
ALA A 420
PHE A 383
 None
 0.91A 4w5nA-3urhA:
undetectable		 4w5nA-3urhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1s AUTOPHAGY PROTEIN 5

(Saccharomyces
cerevisiae) 		PF04106
(APG5) 		3 VAL A  46
ALA A 134
PHE A  74
 None
 0.82A 4w5nA-3w1sA:
undetectable		 4w5nA-3w1sA:
16.38