SIMILAR PATTERNS OF AMINO ACIDS FOR 4V3U_C_H4BC760

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3j PEROXIDASE

(Coprinopsis
cinerea) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 MET A 268
VAL A 177
TRP A 258
PHE A 211
 None
None
None
HSO  A 183 ( 3.5A)
 1.26A 4v3uC-1h3jA:
0.0
4v3uD-1h3jA:
0.0		 4v3uC-1h3jA:
22.59
4v3uD-1h3jA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 ARG A 130
TRP A  97
PHE A 131
GLU A  95
 None
 1.38A 4v3uC-1kexA:
0.0
4v3uD-1kexA:
undetectable		 4v3uC-1kexA:
17.18
4v3uD-1kexA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		4 ARG A 282
VAL A 226
PHE A 220
GLU A 222
 None
 1.32A 4v3uC-1kh2A:
0.3
4v3uD-1kh2A:
0.0		 4v3uC-1kh2A:
23.65
4v3uD-1kh2A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
 None
 1.36A 4v3uC-1l5jA:
0.0
4v3uD-1l5jA:
0.0		 4v3uC-1l5jA:
20.19
4v3uD-1l5jA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 MET A 336
ARG A 596
VAL A 677
TRP A 678
 H4B  A 760 ( 3.8A)
H4B  A 760 (-3.5A)
H4B  A 760 (-4.6A)
H4B  A 760 ( 3.6A)
 0.49A 4v3uC-1lzxA:
61.2
4v3uD-1lzxA:
62.3		 4v3uC-1lzxA:
96.89
4v3uD-1lzxA:
96.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 VAL D  28
TRP D  31
PHE D  35
GLU D 132
 None
 1.37A 4v3uC-1mhzD:
0.0
4v3uD-1mhzD:
0.0		 4v3uC-1mhzD:
20.82
4v3uD-1mhzD:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mns MANDELATE RACEMASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 318
VAL A 163
PHE A 160
GLU A 157
 None
 1.40A 4v3uC-1mnsA:
0.0
4v3uD-1mnsA:
0.0		 4v3uC-1mnsA:
22.32
4v3uD-1mnsA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN

(Pseudomonas
aeruginosa) 		PF01475
(FUR) 		4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
 None
 0.97A 4v3uC-1mzbA:
0.9
4v3uD-1mzbA:
0.3		 4v3uC-1mzbA:
14.52
4v3uD-1mzbA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 MET A 440
VAL A 401
TRP A 435
PHE A 432
 None
 1.00A 4v3uC-1pduA:
0.0
4v3uD-1pduA:
0.0		 4v3uC-1pduA:
20.19
4v3uD-1pduA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhc F420-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Methanoculleus
thermophilus) 		PF00296
(Bac_luciferase) 		4 MET A 282
VAL A 232
PHE A 321
GLU A 293
 None
 1.42A 4v3uC-1rhcA:
0.5
4v3uD-1rhcA:
undetectable		 4v3uC-1rhcA:
20.53
4v3uD-1rhcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09152
(DUF1937) 		4 ARG A   2
VAL A  28
TRP A 110
PHE A 117
 None
 1.50A 4v3uC-1t1jA:
undetectable
4v3uD-1t1jA:
undetectable		 4v3uC-1t1jA:
15.40
4v3uD-1t1jA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermotoga
maritima) 		PF01048
(PNP_UDP_1) 		4 VAL A 221
TRP A 162
PHE A 265
GLU A 161
 None
 1.47A 4v3uC-1vmkA:
undetectable
4v3uD-1vmkA:
undetectable		 4v3uC-1vmkA:
22.33
4v3uD-1vmkA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		4 MET A  17
VAL A  35
PHE A  26
GLU A  21
 None
 1.08A 4v3uC-1wf0A:
undetectable
4v3uD-1wf0A:
undetectable		 4v3uC-1wf0A:
13.14
4v3uD-1wf0A:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
 None
 1.12A 4v3uC-1wqlB:
undetectable
4v3uD-1wqlB:
undetectable		 4v3uC-1wqlB:
17.80
4v3uD-1wqlB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
 None
 1.07A 4v3uC-2b39A:
2.5
4v3uD-2b39A:
undetectable		 4v3uC-2b39A:
13.25
4v3uD-2b39A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL I 375
TRP I 225
PHE I 274
GLU I 378
 None
 1.48A 4v3uC-2b4xI:
undetectable
4v3uD-2b4xI:
undetectable		 4v3uC-2b4xI:
22.20
4v3uD-2b4xI:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ARG A 586
VAL A 578
TRP A 579
GLU A 555
 None
 1.31A 4v3uC-2fjaA:
undetectable
4v3uD-2fjaA:
undetectable		 4v3uC-2fjaA:
21.93
4v3uD-2fjaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 ARG A  62
VAL A 367
TRP B 788
GLU A 360
 None
 1.35A 4v3uC-2fjaA:
undetectable
4v3uD-2fjaA:
undetectable		 4v3uC-2fjaA:
21.93
4v3uD-2fjaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glf PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Thermotoga
maritima) 		PF02127
(Peptidase_M18) 		4 ARG A 261
VAL A 443
PHE A  21
GLU A  17
 None
 1.28A 4v3uC-2glfA:
undetectable
4v3uD-2glfA:
undetectable		 4v3uC-2glfA:
23.42
4v3uD-2glfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 MET A  31
ARG A  53
VAL A  70
GLU A  34
 None
 1.46A 4v3uC-2vdaA:
3.3
4v3uD-2vdaA:
undetectable		 4v3uC-2vdaA:
18.72
4v3uD-2vdaA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 VAL A 245
TRP A 252
PHE A 254
GLU A 251
 None
None
None
MRD  A1301 (-4.3A)
 1.40A 4v3uC-2vy0A:
undetectable
4v3uD-2vy0A:
undetectable		 4v3uC-2vy0A:
20.28
4v3uD-2vy0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.42A 4v3uC-2w4oA:
undetectable
4v3uD-2w4oA:
1.5		 4v3uC-2w4oA:
21.36
4v3uD-2w4oA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 ARG A 159
VAL A 164
PHE A  98
GLU A 108
 None
 1.45A 4v3uC-2xhyA:
0.3
4v3uD-2xhyA:
undetectable		 4v3uC-2xhyA:
20.87
4v3uD-2xhyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 ARG A 211
VAL A 239
PHE A 309
GLU A 305
 None
 1.27A 4v3uC-2ywbA:
undetectable
4v3uD-2ywbA:
undetectable		 4v3uC-2ywbA:
22.78
4v3uD-2ywbA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF13302
(Acetyltransf_3) 		4 VAL A  64
TRP A  66
PHE A   4
GLU A   6
 None
 1.39A 4v3uC-2z11A:
undetectable
4v3uD-2z11A:
undetectable		 4v3uC-2z11A:
19.21
4v3uD-2z11A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1k (NEO)PULLULANASE

(Thermus
thermophilus) 		PF00128
(Alpha-amylase) 		4 ARG A 100
VAL A  89
TRP A 191
PHE A 194
 None
 1.48A 4v3uC-2z1kA:
undetectable
4v3uD-2z1kA:
undetectable		 4v3uC-2z1kA:
20.47
4v3uD-2z1kA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT

(Cupriavidus
pinatubonensis) 		no annotation 4 VAL A 314
TRP A 293
TRP A 374
GLU A 372
 None
None
None
EDO  A 404 ( 3.8A)
 1.43A 4v3uC-3b7fA:
undetectable
4v3uD-3b7fA:
undetectable		 4v3uC-3b7fA:
20.22
4v3uD-3b7fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		4 ARG A 437
TRP A 485
PHE A 489
GLU A 484
 None
 1.02A 4v3uC-3ckbA:
2.6
4v3uD-3ckbA:
undetectable		 4v3uC-3ckbA:
19.46
4v3uD-3ckbA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2w TAR DNA-BINDING
PROTEIN 43

(Mus musculus) 		PF00076
(RRM_1) 		4 MET A 202
VAL A 220
PHE A 211
GLU A 206
 None
 1.06A 4v3uC-3d2wA:
undetectable
4v3uD-3d2wA:
undetectable		 4v3uC-3d2wA:
12.72
4v3uD-3d2wA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE

(Desulfovibrio
gigas) 		PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 ARG A  66
VAL A 387
TRP B  88
GLU A 380
 None
 1.28A 4v3uC-3gyxA:
2.4
4v3uD-3gyxA:
undetectable		 4v3uC-3gyxA:
21.00
4v3uD-3gyxA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ARG A 269
VAL A 260
TRP A 257
PHE A 252
 None
 1.43A 4v3uC-3ma6A:
undetectable
4v3uD-3ma6A:
undetectable		 4v3uC-3ma6A:
21.28
4v3uD-3ma6A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		4 ARG A 944
TRP A1001
PHE A 946
GLU A 908
 None
 1.48A 4v3uC-3n3kA:
undetectable
4v3uD-3n3kA:
undetectable		 4v3uC-3n3kA:
19.91
4v3uD-3n3kA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
 None
 1.25A 4v3uC-3owcA:
1.6
4v3uD-3owcA:
undetectable		 4v3uC-3owcA:
17.54
4v3uD-3owcA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 MET A 259
VAL A 169
TRP A 249
PHE A 203
 None
 1.29A 4v3uC-3q3uA:
undetectable
4v3uD-3q3uA:
undetectable		 4v3uC-3q3uA:
21.82
4v3uD-3q3uA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		4 VAL A 149
TRP A 146
PHE A 162
GLU A 187
 None
 1.23A 4v3uC-3rjyA:
1.1
4v3uD-3rjyA:
undetectable		 4v3uC-3rjyA:
20.78
4v3uD-3rjyA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		4 VAL A2274
TRP A2314
PHE A2329
GLU A2310
 None
 1.25A 4v3uC-3sbgA:
undetectable
4v3uD-3sbgA:
undetectable		 4v3uC-3sbgA:
22.26
4v3uD-3sbgA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 VAL A 240
TRP A 239
PHE A 305
GLU A 265
 None
 1.40A 4v3uC-3ti8A:
undetectable
4v3uD-3ti8A:
undetectable		 4v3uC-3ti8A:
21.75
4v3uD-3ti8A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tix CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 4 ARG B 924
VAL B 944
PHE B 953
GLU B 951
 None
 1.28A 4v3uC-3tixB:
undetectable
4v3uD-3tixB:
undetectable		 4v3uC-3tixB:
21.16
4v3uD-3tixB:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE

(Coxiella
burnetii) 		PF01725
(Ham1p_like) 		4 VAL A 162
TRP A 140
PHE A 118
GLU A 141
 None
 1.25A 4v3uC-3tquA:
undetectable
4v3uD-3tquA:
undetectable		 4v3uC-3tquA:
19.76
4v3uD-3tquA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa) 		PF02223
(Thymidylate_kin) 		4 ARG A 109
VAL A 166
PHE A 162
GLU A 156
 None
None
None
MG  A 213 (-3.2A)
 1.34A 4v3uC-3uxmA:
undetectable
4v3uD-3uxmA:
undetectable		 4v3uC-3uxmA:
20.53
4v3uD-3uxmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ARG A 373
VAL A 412
TRP A 383
PHE A 370
 None
 1.44A 4v3uC-4fnqA:
undetectable
4v3uD-4fnqA:
undetectable		 4v3uC-4fnqA:
20.60
4v3uD-4fnqA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 MET A 258
VAL A 265
TRP A  62
PHE A  85
 None
 1.34A 4v3uC-4g76A:
undetectable
4v3uD-4g76A:
undetectable		 4v3uC-4g76A:
20.09
4v3uD-4g76A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 VAL B 351
TRP B 355
PHE B 327
GLU B 424
 None
 1.11A 4v3uC-4l37B:
undetectable
4v3uD-4l37B:
undetectable		 4v3uC-4l37B:
19.54
4v3uD-4l37B:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmv GLUTATHIONE
TRANSFERASE

(Phanerochaete
chrysosporium) 		PF13417
(GST_N_3) 		4 ARG A  29
VAL A  73
PHE A   7
GLU A  42
 None
FLC  A 300 (-4.1A)
None
None
 1.15A 4v3uC-4lmvA:
undetectable
4v3uD-4lmvA:
undetectable		 4v3uC-4lmvA:
21.09
4v3uD-4lmvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		4 ARG A 385
TRP A 387
TRP A 218
PHE A 286
 None
 1.41A 4v3uC-4mh1A:
undetectable
4v3uD-4mh1A:
undetectable		 4v3uC-4mh1A:
21.13
4v3uD-4mh1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN

(Saccharopolyspora
spinosa) 		PF08241
(Methyltransf_11) 		4 ARG A  75
VAL A  79
PHE A 141
GLU A 162
 None
 1.31A 4v3uC-4pneA:
undetectable
4v3uD-4pneA:
undetectable		 4v3uC-4pneA:
21.10
4v3uD-4pneA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbu ZMAA

(Bacillus cereus) 		PF00698
(Acyl_transf_1) 		4 ARG A   9
TRP A 428
PHE A 431
GLU A 429
 None
 1.41A 4v3uC-4qbuA:
undetectable
4v3uD-4qbuA:
undetectable		 4v3uC-4qbuA:
22.61
4v3uD-4qbuA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
 None
 1.17A 4v3uC-4xj6A:
undetectable
4v3uD-4xj6A:
undetectable		 4v3uC-4xj6A:
19.92
4v3uD-4xj6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
 None
 1.02A 4v3uC-4xj6A:
undetectable
4v3uD-4xj6A:
undetectable		 4v3uC-4xj6A:
19.92
4v3uD-4xj6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		4 VAL A 288
TRP A 292
PHE A 277
GLU A 279
 None
 1.40A 4v3uC-4ylrA:
undetectable
4v3uD-4ylrA:
undetectable		 4v3uC-4ylrA:
23.03
4v3uD-4ylrA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zva DIGUANYLATE CYCLASE
DOSC

(Escherichia
coli) 		PF11563
(Protoglobin) 		4 MET A   8
VAL A  84
TRP A  12
GLU A  11
 None
 1.33A 4v3uC-4zvaA:
undetectable
4v3uD-4zvaA:
undetectable		 4v3uC-4zvaA:
18.56
4v3uD-4zvaA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 ARG A 505
VAL A 736
TRP A 732
GLU A 731
 None
 1.37A 4v3uC-5by3A:
1.7
4v3uD-5by3A:
undetectable		 4v3uC-5by3A:
19.67
4v3uD-5by3A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 ARG A 316
VAL A 438
TRP A 439
GLU A 418
 BE2  A1476 (-4.0A)
BE2  A1476 ( 4.3A)
BE2  A1476 ( 3.7A)
None
 1.34A 4v3uC-5fjnA:
undetectable
4v3uD-5fjnA:
undetectable		 4v3uC-5fjnA:
23.09
4v3uD-5fjnA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.10A 4v3uC-5m8tA:
undetectable
4v3uD-5m8tA:
undetectable		 4v3uC-5m8tA:
20.25
4v3uD-5m8tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		PF03641
(Lysine_decarbox) 		4 MET A 112
ARG A 155
VAL A 104
PHE A 159
 None
 1.45A 4v3uC-5wq3A:
undetectable
4v3uD-5wq3A:
undetectable		 4v3uC-5wq3A:
21.43
4v3uD-5wq3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 4 MET A 249
VAL A 231
PHE A 258
GLU A 253
 None
 1.00A 4v3uC-5x89A:
undetectable
4v3uD-5x89A:
undetectable		 4v3uC-5x89A:
12.96
4v3uD-5x89A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS

(Homo sapiens) 		no annotation 4 ARG A 129
VAL A  65
PHE A 113
GLU A 106
 None
 1.23A 4v3uC-5xf7A:
undetectable
4v3uD-5xf7A:
undetectable		 4v3uC-5xf7A:
14.43
4v3uD-5xf7A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VH CHAIN OF 059-152
VL CHAIN OF 059-152

(Homo sapiens) 		no annotation 4 MET H 105
VAL D  98
TRP D  91
TRP H  49
 None
 1.22A 4v3uC-5xwdH:
undetectable
4v3uD-5xwdH:
undetectable		 4v3uC-5xwdH:
13.62
4v3uD-5xwdH:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 4 ARG A 331
VAL A 317
TRP A 316
GLU A 322
 None
UDP  A 501 ( 4.8A)
None
None
 1.27A 4v3uC-6bk1A:
undetectable
4v3uD-6bk1A:
undetectable		 4v3uC-6bk1A:
13.48
4v3uD-6bk1A:
13.48