SIMILAR PATTERNS OF AMINO ACIDS FOR 4V32_C_EF2C151

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ahs AFRICAN HORSE
SICKNESS VIRUS
(SEROTYPE 4) VP7

(African horse
sickness virus) 		PF00897
(Orbi_VP7) 		4 ASN A 235
PHE A 209
TRP A 188
PHE A 245
 None
 1.37A 4v32C-1ahsA:
undetectable		 4v32C-1ahsA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3e ALCOHOL
DEHYDROGENASE, CLASS
II

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASN A 332
PRO A 331
TRP A 324
PHE A 180
 None
 1.46A 4v32C-1e3eA:
0.0		 4v32C-1e3eA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 ASN A1040
PRO A1037
PHE A1038
PHE A1103
 None
 1.36A 4v32C-1lu4A:
0.0		 4v32C-1lu4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vka MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 ASN A 118
PHE A 115
TRP A 110
PHE A 107
 None
 1.37A 4v32C-1vkaA:
undetectable		 4v32C-1vkaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wir PROTEIN ARGININE
N-METHYLTRANSFERASE
3

(Mus musculus) 		no annotation 4 ASN A  79
PRO A  80
TRP A  83
PHE A  63
 None
 1.30A 4v32C-1wirA:
0.0		 4v32C-1wirA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i32 ANTI-SILENCING
FACTOR 1 PARALOG A

(Homo sapiens) 		PF04729
(ASF1_hist_chap) 		4 ASN A  80
PRO A  81
PHE A 132
PHE A  22
 None
 1.44A 4v32C-2i32A:
undetectable		 4v32C-2i32A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ltm NFU1 IRON-SULFUR
CLUSTER SCAFFOLD
HOMOLOG,
MITOCHONDRIAL

(Homo sapiens) 		PF08712
(Nfu_N) 		4 ASN A  22
PRO A  21
TRP A  82
PHE A  26
 None
 1.36A 4v32C-2ltmA:
undetectable		 4v32C-2ltmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		4 ASN A 101
PRO A 128
PHE A 127
PHE A 121
 ACT  A 286 (-3.2A)
ACT  A 286 ( 4.4A)
CL  A 290 ( 4.7A)
None
 1.38A 4v32C-2p10A:
0.0		 4v32C-2p10A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjz MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 ASN A 118
PHE A 115
TRP A 110
PHE A 107
 None
 1.40A 4v32C-2qjzA:
undetectable		 4v32C-2qjzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8u MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 1

(Homo sapiens) 		PF00307
(CH) 		4 ASN A 118
PHE A 115
TRP A 110
PHE A 107
 None
 1.38A 4v32C-2r8uA:
undetectable		 4v32C-2r8uA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 ASN A 494
PRO A 493
TRP A 257
PHE A 438
 None
 1.40A 4v32C-2xydA:
undetectable		 4v32C-2xydA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzl ATP-DEPENDENT
HELICASE NAM7

(Saccharomyces
cerevisiae) 		PF09416
(UPF1_Zn_bind)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 PRO A 338
TRP A 311
TRP A 269
PHE A 347
 None
 1.26A 4v32C-2xzlA:
0.0		 4v32C-2xzlA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aad HISTONE CHAPERONE
ASF1A

(Homo sapiens) 		PF04729
(ASF1_hist_chap) 		4 ASN B  80
PRO B  81
PHE B 132
PHE B  22
 None
 1.48A 4v32C-3aadB:
undetectable		 4v32C-3aadB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co1 MICROTUBULE-ASSOCIAT
ED PROTEIN RP/EB
FAMILY MEMBER 3

(Homo sapiens) 		PF00307
(CH) 		4 ASN A 118
PHE A 115
TRP A 110
PHE A 107
 None
 1.42A 4v32C-3co1A:
undetectable		 4v32C-3co1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq4 CUBILIN

(Homo sapiens) 		PF00431
(CUB) 		4 ASN B1066
PRO B1065
PHE B1064
PHE B1143
 None
NAG  B2002 (-4.5A)
NAG  B2002 ( 4.8A)
None
 1.48A 4v32C-3kq4B:
undetectable		 4v32C-3kq4B:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		4 PRO A 216
PHE A 220
TRP A 357
PHE A 307
 None
 1.33A 4v32C-3lm3A:
undetectable		 4v32C-3lm3A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		4 ASN A 161
TRP A 216
TRP A 152
PHE A 189
 None
 1.30A 4v32C-3nfvA:
undetectable		 4v32C-3nfvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.34A 4v32C-3nixA:
undetectable		 4v32C-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7o ENDOGLUCANASE

(Thermotoga
maritima) 		PF01670
(Glyco_hydro_12) 		4 ASN A  25
PRO A  67
PHE A  47
PHE A  13
 None
 1.43A 4v32C-3o7oA:
undetectable		 4v32C-3o7oA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 ASN A 164
PRO A 165
PHE A 309
PHE A 349
 LLP  A 221 ( 3.9A)
None
None
None
 1.46A 4v32C-3op7A:
undetectable		 4v32C-3op7A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		4 ASN B 126
PHE B 491
TRP B 490
PHE B 463
 None
 0.83A 4v32C-3p8cB:
undetectable		 4v32C-3p8cB:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		4 ASN A 181
PRO A 182
PHE A 217
PHE A 137
 HEC  A1004 ( 4.7A)
None
None
None
 1.46A 4v32C-3s7wA:
undetectable		 4v32C-3s7wA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w79 FMN-DEPENDENT
NADH-AZOREDUCTASE

(Bacillus sp.
B29) 		PF02525
(Flavodoxin_2) 		4 ASN A  12
PRO A  11
PHE A  45
PHE A   6
 None
 1.29A 4v32C-3w79A:
undetectable		 4v32C-3w79A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		4 ASN A 248
PHE A 198
TRP A 237
PHE A 226
 None
 1.39A 4v32C-4aysA:
undetectable		 4v32C-4aysA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASN A 239
PRO A 248
PHE A 249
PHE A 338
 None
 1.41A 4v32C-4bi9A:
undetectable		 4v32C-4bi9A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		6 ASN B 353
PRO B 354
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.60A 4v32C-4ci2B:
14.5		 4v32C-4ci2B:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN

(Microbacterium
liquefaciens) 		PF02133
(Transp_cyt_pur) 		4 ASN A 282
PRO A 283
PHE A  46
PHE A 120
 None
 1.38A 4v32C-4d1dA:
undetectable		 4v32C-4d1dA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gba DCN1-LIKE PROTEIN 3

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 ASN A 244
PHE A 187
TRP A 209
PHE A 213
 None
 1.01A 4v32C-4gbaA:
undetectable		 4v32C-4gbaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASN A 503
PRO A 504
PHE A 494
PHE A 121
 None
 1.49A 4v32C-4ptfA:
undetectable		 4v32C-4ptfA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q04 URE3-BP SEQUENCE
SPECIFIC DNA BINDING
PROTEIN

(Entamoeba
histolytica) 		PF13499
(EF-hand_7) 		4 PRO A  40
PHE A  39
TRP A  37
PHE A  96
 None
 1.46A 4v32C-4q04A:
undetectable		 4v32C-4q04A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 ASN A 235
PRO A 234
PHE A 233
PHE A 288
 None
 1.38A 4v32C-4tweA:
undetectable		 4v32C-4tweA:
10.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 4 TRP C 382
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.37A 4v32C-4tzcC:
15.3		 4v32C-4tzcC:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 ASN L 295
PHE L 296
TRP L 504
PHE L 299
 None
 1.27A 4v32C-4u9iL:
undetectable		 4v32C-4u9iL:
13.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 6 ASN A  50
PRO A  51
PHE A  77
TRP A  79
TRP A  85
TRP A  99
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 0.77A 4v32C-4v30A:
19.6		 4v32C-4v30A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bo0 HISTONE CHAPERONE
ASF1B

(Homo sapiens) 		PF04729
(ASF1_hist_chap) 		4 ASN D  80
PRO D  81
PHE D 132
PHE D  22
 None
 1.46A 4v32C-5bo0D:
undetectable		 4v32C-5bo0D:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		4 ASN A 612
PRO A 613
PHE A 615
PHE A 555
 None
 1.48A 4v32C-5fx8A:
undetectable		 4v32C-5fx8A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 4 ASN C 481
PRO C 482
PHE C 535
PHE C 563
 SFG  C1002 (-3.8A)
None
None
None
 1.49A 4v32C-5hr4C:
undetectable		 4v32C-5hr4C:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 5 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
None
 0.72A 4v32C-5hxbZ:
10.7		 4v32C-5hxbZ:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 5 PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.54A 4v32C-5hxbZ:
10.7		 4v32C-5hxbZ:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaz DNA PRIMASE

(Pseudomonas
aeruginosa) 		PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13662
(Toprim_4) 		4 ASN A 169
PRO A 164
PHE A 162
PHE A 221
 None
 1.41A 4v32C-5vazA:
undetectable		 4v32C-5vazA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvr KLLA0C04147P

(Kluyveromyces
lactis) 		PF01237
(Oxysterol_BP) 		4 PRO A1154
TRP A1204
TRP A1225
PHE A1220
 None
 1.49A 4v32C-5wvrA:
undetectable		 4v32C-5wvrA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wx3 ALKYLDIKETIDE-COA
SYNTHASE

(Tetradium
ruticarpum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASN A 232
PHE A 231
TRP A 361
PHE A 281
 None
 1.13A 4v32C-5wx3A:
undetectable		 4v32C-5wx3A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5d BETA-XYLOSIDASE

(Geobacillus
thermoleovorans) 		no annotation 4 ASN A 445
PRO A 446
PHE A 371
PHE A 485
 None
GOL  A 605 (-4.5A)
GOL  A 605 (-3.6A)
None
 1.41A 4v32C-5z5dA:
undetectable		 4v32C-5z5dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 4 ASN F 360
PHE F 363
TRP F 418
PHE F 406
 None
 1.31A 4v32C-6btmF:
undetectable		 4v32C-6btmF:
16.80