SIMILAR PATTERNS OF AMINO ACIDS FOR 4V32_B_EF2B151_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lu4 SOLUBLE SECRETED
ANTIGEN MPT53

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 ASN A1040
PRO A1037
PHE A1038
PHE A1103
 None
 1.39A 4v32B-1lu4A:
0.0		 4v32B-1lu4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr0 ACTIN INTERACTING
PROTEIN 1

(Caenorhabditis
elegans) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN A 199
PRO A 200
TRP A 247
PHE A 228
 None
 1.28A 4v32B-1nr0A:
0.0		 4v32B-1nr0A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2

(Mus musculus) 		PF09258
(Glyco_transf_64) 		4 ASN A 220
PHE A 219
TRP A 168
PHE A 165
 EDO  A 403 ( 3.8A)
None
None
None
 1.17A 4v32B-1omxA:
undetectable		 4v32B-1omxA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0x TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Enterococcus
faecalis) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ASN A  84
PRO A  68
PHE A  81
PHE A 200
 None
 1.44A 4v32B-1z0xA:
undetectable		 4v32B-1z0xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxy MACROPHAGE
METALLOELASTASE

(Homo sapiens) 		PF00045
(Hemopexin) 		4 ASN A 465
PHE A 468
TRP A 307
PHE A 300
 None
 1.36A 4v32B-2jxyA:
undetectable		 4v32B-2jxyA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdy BH0842 PROTEIN

(Bacillus
halodurans) 		PF14498
(Glyco_hyd_65N_2) 		4 ASN A 358
PRO A  94
TRP A  14
PHE A  30
 None
 1.43A 4v32B-2rdyA:
0.0		 4v32B-2rdyA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		PF00073
(Rhv) 		4 ASN 3 157
PRO 3 159
PHE 3 124
PHE 3 108
 None
 1.36A 4v32B-2ws93:
undetectable		 4v32B-2ws93:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3juu PORPHYRANASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		4 ASN A 261
PRO A 262
TRP A 260
TRP A 172
 None
 1.46A 4v32B-3juuA:
undetectable		 4v32B-3juuA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.06A 4v32B-3nixA:
0.0		 4v32B-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 ASN A 656
PHE A 657
TRP A 564
PHE A 566
 None
 1.14A 4v32B-3uelA:
0.0		 4v32B-3uelA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASN A 338
PRO A 339
PHE A 344
PHE A 424
 None
 1.26A 4v32B-4aeeA:
undetectable		 4v32B-4aeeA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bi9 3-KETOACYL-COA
THIOLASE, PUTATIVE

(Trypanosoma
brucei) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ASN A 239
PRO A 248
PHE A 249
PHE A 338
 None
 1.30A 4v32B-4bi9A:
undetectable		 4v32B-4bi9A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		4 ASN A 490
PRO A 479
PHE A 493
PHE A 674
 None
 1.42A 4v32B-4c4aA:
undetectable		 4v32B-4c4aA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		6 ASN B 353
PRO B 354
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.46A 4v32B-4ci2B:
16.4		 4v32B-4ci2B:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN

(Microbacterium
liquefaciens) 		PF02133
(Transp_cyt_pur) 		4 ASN A 282
PRO A 283
PHE A  46
PHE A 120
 None
 1.06A 4v32B-4d1dA:
undetectable		 4v32B-4d1dA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ASN A  42
PRO A  43
PHE A  53
PHE A  82
 None
 1.42A 4v32B-4eqvA:
undetectable		 4v32B-4eqvA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		4 ASN A 653
PHE A 654
TRP A 561
PHE A 563
 None
 1.13A 4v32B-4fc2A:
undetectable		 4v32B-4fc2A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gba DCN1-LIKE PROTEIN 3

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 ASN A 244
PHE A 187
TRP A 209
PHE A 213
 None
 1.02A 4v32B-4gbaA:
undetectable		 4v32B-4gbaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oan TRAP DICARBOXYLATE
TRANSPORTER DCTP
SUBUNIT

(Rhodopseudomonas
palustris) 		PF03480
(DctP) 		4 ASN A 218
PRO A 219
TRP A 185
PHE A 189
 X2X  A 402 (-2.8A)
None
None
None
 1.36A 4v32B-4oanA:
undetectable		 4v32B-4oanA:
15.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 4 TRP C 382
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.26A 4v32B-4tzcC:
15.9		 4v32B-4tzcC:
33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 ASN A1041
PRO A1043
TRP A1040
PHE A1134
 None
 1.11A 4v32B-4um2A:
undetectable		 4v32B-4um2A:
11.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 6 ASN A  50
PRO A  51
PHE A  77
TRP A  79
TRP A  85
TRP A  99
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 0.30A 4v32B-4v30A:
22.6		 4v32B-4v30A:
99.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d62 AGGLUTININ

(Marasmius
oreades) 		PF14200
(RicinB_lectin_2) 		4 ASN A  64
PHE A  66
TRP A 234
PHE A 239
 None
 1.46A 4v32B-5d62A:
undetectable		 4v32B-5d62A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 4 ASN A 186
PRO A 187
PHE A 120
PHE A  93
 None
 1.44A 4v32B-5h7wA:
undetectable		 4v32B-5h7wA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 6 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.47A 4v32B-5hxbZ:
11.5		 4v32B-5hxbZ:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		4 ASN A 558
PRO A 610
PHE A 560
PHE A 563
 None
 1.33A 4v32B-5szsA:
undetectable		 4v32B-5szsA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy3 -

(-) 		no annotation 4 ASN A 133
PRO A 129
PHE A  51
PHE A 375
 None
 1.48A 4v32B-5yy3A:
undetectable		 4v32B-5yy3A:
undetectable