SIMILAR PATTERNS OF AMINO ACIDS FOR 4V32_A_EF2A151_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lu4 | SOLUBLE SECRETEDANTIGEN MPT53 (Mycobacteriumtuberculosis) |
PF00578(AhpC-TSA) | 4 | ASN A1040PRO A1037PHE A1038PHE A1103 | None | 1.39A | 4v32A-1lu4A:0.0 | 4v32A-1lu4A:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z0x | TRANSCRIPTIONALREGULATOR, TETRFAMILY (Enterococcusfaecalis) |
PF00440(TetR_N)PF02909(TetR_C) | 4 | ASN A 84PRO A 68PHE A 81PHE A 200 | None | 1.42A | 4v32A-1z0xA:undetectable | 4v32A-1z0xA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jxy | MACROPHAGEMETALLOELASTASE (Homo sapiens) |
PF00045(Hemopexin) | 4 | ASN A 465PHE A 468TRP A 307PHE A 300 | None | 1.40A | 4v32A-2jxyA:0.3 | 4v32A-2jxyA:17.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rdy | BH0842 PROTEIN (Bacillushalodurans) |
PF14498(Glyco_hyd_65N_2) | 4 | ASN A 358PRO A 94TRP A 14PHE A 30 | None | 1.47A | 4v32A-2rdyA:undetectable | 4v32A-2rdyA:11.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ws9 | P1 (Equine rhinitisA virus) |
PF00073(Rhv) | 4 | ASN 3 157PRO 3 159PHE 3 124PHE 3 108 | None | 1.35A | 4v32A-2ws93:0.0 | 4v32A-2ws93:16.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzl | ATP-DEPENDENTHELICASE NAM7 (Saccharomycescerevisiae) |
PF09416(UPF1_Zn_bind)PF13086(AAA_11)PF13087(AAA_12) | 4 | PRO A 338TRP A 311TRP A 269PHE A 347 | None | 1.43A | 4v32A-2xzlA:undetectable | 4v32A-2xzlA:8.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z1k | (NEO)PULLULANASE (Thermusthermophilus) |
PF00128(Alpha-amylase) | 4 | ASN A 309PRO A 344PHE A 338PHE A 411 | None | 1.47A | 4v32A-2z1kA:undetectable | 4v32A-2z1kA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zsi | PROBABLE GIBBERELLINRECEPTOR GID1L1 (Arabidopsisthaliana) |
PF07859(Abhydrolase_3) | 4 | ASN A 264PRO A 265PHE A 221TRP A 294 | None | 1.47A | 4v32A-2zsiA:0.0 | 4v32A-2zsiA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb9 | PRE-MRNA-SPLICINGFACTOR SPP42 (Schizosaccharomycespombe) |
PF08082(PRO8NT)PF08083(PROCN)PF10596(U6-snRNA_bdg)PF10597(U5_2-snRNA_bdg)PF10598(RRM_4)PF12134(PRP8_domainIV) | 4 | PHE A 652TRP A 653TRP A 657PHE A 605 | None | 1.48A | 4v32A-3jb9A:undetectable | 4v32A-3jb9A:4.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3juu | PORPHYRANASE B (Zobelliagalactanivorans) |
PF00722(Glyco_hydro_16) | 4 | ASN A 261PRO A 262TRP A 260TRP A 172 | None | 1.47A | 4v32A-3juuA:0.0 | 4v32A-3juuA:18.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm3 | UNCHARACTERIZEDPROTEIN (Parabacteroidesdistasonis) |
PF12979(DUF3863)PF12980(DUF3864) | 4 | PRO A 216PHE A 220TRP A 357PHE A 307 | None | 1.47A | 4v32A-3lm3A:undetectable | 4v32A-3lm3A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nix | FLAVOPROTEIN/DEHYDROGENASE (Cytophagahutchinsonii) |
PF01494(FAD_binding_3) | 4 | PRO A 50PHE A 89TRP A 99TRP A 101 | None | 1.14A | 4v32A-3nixA:undetectable | 4v32A-3nixA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nra | ASPARTATEAMINOTRANSFERASE (Rhodobactersphaeroides) |
PF00155(Aminotran_1_2) | 4 | ASN A 189PRO A 190PHE A 340PHE A 383 | LLP A 252 (-4.0A)NoneNoneNone | 1.32A | 4v32A-3nraA:undetectable | 4v32A-3nraA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uel | POLY(ADP-RIBOSE)GLYCOHYDROLASE (Rattusnorvegicus) |
PF05028(PARG_cat) | 4 | ASN A 656PHE A 657TRP A 564PHE A 566 | None | 1.16A | 4v32A-3uelA:undetectable | 4v32A-3uelA:9.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aee | ALPHA AMYLASE,CATALYTIC REGION (Staphylothermusmarinus) |
PF00128(Alpha-amylase) | 4 | ASN A 338PRO A 339PHE A 344PHE A 424 | None | 1.23A | 4v32A-4aeeA:undetectable | 4v32A-4aeeA:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bi9 | 3-KETOACYL-COATHIOLASE, PUTATIVE (Trypanosomabrucei) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | ASN A 239PRO A 248PHE A 249PHE A 338 | None | 1.32A | 4v32A-4bi9A:undetectable | 4v32A-4bi9A:14.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c4a | PROTEIN ARGININEN-METHYLTRANSFERASE7 (Mus musculus) |
PF06325(PrmA) | 4 | ASN A 490PRO A 479PHE A 493PHE A 674 | None | 1.45A | 4v32A-4c4aA:undetectable | 4v32A-4c4aA:10.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 4 | ASN A 227PHE A 231TRP A 162TRP A 260 | None | 1.41A | 4v32A-4cakA:undetectable | 4v32A-4cakA:8.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci2 | PROTEIN CEREBLON (Gallus gallus) |
PF02190(LON_substr_bdg)PF03226(Yippee-Mis18) | 6 | ASN B 353PRO B 354TRP B 382TRP B 388TRP B 402PHE B 404 | LVY B1429 (-4.1A)LVY B1429 (-4.7A)LVY B1429 (-3.1A)LVY B1429 (-3.5A)LVY B1429 (-3.7A)LVY B1429 (-4.5A) | 0.41A | 4v32A-4ci2B:15.9 | 4v32A-4ci2B:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d1d | HYDANTOIN TRANSPORTPROTEIN (Microbacteriumliquefaciens) |
PF02133(Transp_cyt_pur) | 4 | ASN A 282PRO A 283PHE A 46PHE A 120 | None | 1.04A | 4v32A-4d1dA:undetectable | 4v32A-4d1dA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eqv | INVERTASE 2 (Saccharomycescerevisiae) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 4 | ASN A 42PRO A 43PHE A 53PHE A 82 | None | 1.42A | 4v32A-4eqvA:undetectable | 4v32A-4eqvA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4er6 | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-79SPECIFIC (Homo sapiens) |
PF08123(DOT1) | 4 | ASN A 241PRO A 130PHE A 243PHE A 272 | AW2 A 502 (-4.3A)NoneNoneNone | 1.47A | 4v32A-4er6A:undetectable | 4v32A-4er6A:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fc2 | POLY(ADP-RIBOSE)GLYCOHYDROLASE (Mus musculus) |
PF05028(PARG_cat) | 4 | ASN A 653PHE A 654TRP A 561PHE A 563 | None | 1.14A | 4v32A-4fc2A:undetectable | 4v32A-4fc2A:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gba | DCN1-LIKE PROTEIN 3 (Homo sapiens) |
PF03556(Cullin_binding) | 4 | ASN A 244PHE A 187TRP A 209PHE A 213 | None | 0.91A | 4v32A-4gbaA:undetectable | 4v32A-4gbaA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h1s | 5'-NUCLEOTIDASE (Homo sapiens) |
PF00149(Metallophos)PF02872(5_nucleotid_C) | 4 | ASN A 186PRO A 187PHE A 120PHE A 93 | None | 1.34A | 4v32A-4h1sA:undetectable | 4v32A-4h1sA:10.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4tzc | PROTEIN CEREBLON (Mus musculus) |
no annotation | 4 | TRP C 382TRP C 388TRP C 402PHE C 404 | EF2 C 502 ( 3.2A)EF2 C 502 (-3.5A)EF2 C 502 (-3.8A)EF2 C 502 (-4.5A) | 0.31A | 4v32A-4tzcC:15.9 | 4v32A-4tzcC:33.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um2 | TELOMERASE-BINDINGPROTEIN EST1A (Homo sapiens) |
PF10373(EST1_DNA_bind)PF10374(EST1) | 4 | ASN A1041PRO A1043TRP A1040PHE A1134 | None | 1.08A | 4v32A-4um2A:undetectable | 4v32A-4um2A:11.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4v30 | CEREBLON ISOFORM 4 (Magnetospirillumgryphiswaldense) |
no annotation | 6 | ASN A 50PRO A 51PHE A 77TRP A 79TRP A 85TRP A 99 | LVY A 151 (-3.8A)LVY A 151 (-4.4A)LVY A 151 (-4.4A)LVY A 151 (-3.2A)LVY A 151 (-3.4A)LVY A 151 (-3.7A) | 0.13A | 4v32A-4v30A:24.0 | 4v32A-4v30A:99.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ww3 | RHODOPSIN (Todarodespacificus) |
PF00001(7tm_1) | 4 | PRO A 276PHE A 303TRP A 274PHE A 83 | NoneNoneRET A 401 ( 4.4A)None | 1.29A | 4v32A-4ww3A:undetectable | 4v32A-4ww3A:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5axi | E3 UBIQUITIN-PROTEINLIGASE CBL-B (Mus musculus) |
PF02262(Cbl_N)PF02761(Cbl_N2)PF02762(Cbl_N3) | 4 | ASN A 251PHE A 252TRP A 250PHE A 236 | None | 1.21A | 4v32A-5axiA:undetectable | 4v32A-5axiA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gin | FIBRILLARIN-LIKERRNA/TRNA2'-O-METHYLTRANSFERASE (Sulfolobussolfataricus) |
PF01269(Fibrillarin) | 4 | ASN E 166PRO E 137PHE E 169PHE E 208 | None | 1.48A | 4v32A-5ginE:undetectable | 4v32A-5ginE:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7w | VENOM5'-NUCLEOTIDASE (Naja atra) |
no annotation | 4 | ASN A 186PRO A 187PHE A 120PHE A 93 | None | 1.37A | 4v32A-5h7wA:undetectable | 4v32A-5h7wA:11.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxb | PROTEIN CEREBLON (Homo sapiens) |
no annotation | 6 | ASN Z 351PRO Z 352TRP Z 380TRP Z 386TRP Z 400PHE Z 402 | 85C Z 502 (-3.6A)85C Z 502 (-4.4A)85C Z 502 (-3.2A)85C Z 502 (-3.4A)85C Z 502 (-3.7A)None | 0.50A | 4v32A-5hxbZ:11.4 | 4v32A-5hxbZ:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lgd | PLATELETGLYCOPROTEIN 4 (Homo sapiens) |
PF01130(CD36) | 4 | ASN A 390PRO A 412PHE A 68PHE A 201 | NoneNoneNonePLM A 512 (-4.9A) | 1.49A | 4v32A-5lgdA:undetectable | 4v32A-5lgdA:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m28 | MALE1 (Lactobacilluscasei) |
PF13416(SBP_bac_8) | 4 | ASN A 92PRO A 93PHE A 121PHE A 75 | None | 1.28A | 4v32A-5m28A:undetectable | 4v32A-5m28A:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5szs | SPIKE GLYCOPROTEIN (HumancoronavirusNL63) |
PF01600(Corona_S1)PF01601(Corona_S2) | 4 | ASN A 558PRO A 610PHE A 560PHE A 563 | None | 1.28A | 4v32A-5szsA:undetectable | 4v32A-5szsA:6.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b2w | PUTATIVEPEPTIDYL-ARGININEDEIMINASE FAMILYPROTEIN (Campylobacterjejuni) |
no annotation | 4 | ASN A 144PHE A 143TRP A 8PHE A 267 | None | 1.27A | 4v32A-6b2wA:undetectable | 4v32A-6b2wA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6v | TELOMERASE REVERSETRANSCRIPTASE (Tetrahymenathermophila) |
no annotation | 4 | ASN A 937PRO A 934PHE A1009PHE A1090 | None | 1.32A | 4v32A-6d6vA:undetectable | 4v32A-6d6vA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f42 | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC1DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC2 (Saccharomycescerevisiae) |
no annotation | 4 | ASN B 945PRO B 946PHE A 710PHE A 557 | None | 1.43A | 4v32A-6f42B:undetectable | 4v32A-6f42B:22.02 |