SIMILAR PATTERNS OF AMINO ACIDS FOR 4V30_C_LVYC151_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ln3	DIHYDRODIOL DEHYDROGENASE (Mus musculus)	PF00248 (Aldo_ket_red)	4	ASN A 127 PRO A 130 TRP A 86 TYR A 53	None MLY A 123 ( 4.7A) None MLY A 105 ( 3.5A)	1.48A	4v30C-3ln3A: 0.0	4v30C-3ln3A: 17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ci2	PROTEIN CEREBLON (Gallus gallus)	PF02190 (LON_substr_bdg) PF03226 (Yippee-Mis18)	5	ASN B 353 PRO B 354 TRP B 382 TRP B 388 TRP B 402	LVY B1429 (-4.1A) LVY B1429 (-4.7A) LVY B1429 (-3.1A) LVY B1429 (-3.5A) LVY B1429 (-3.7A)	0.58A	4v30C-4ci2B: 14.5	4v30C-4ci2B: 16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4l7a	UNCHARACTERIZED PROTEIN (Bacteroides caccae)	PF15890 (Peptidase_Mx1)	4	ASN A 59 PRO A 60 TRP A 52 TYR A 297	None	1.36A	4v30C-4l7aA: 0.0	4v30C-4l7aA: 17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hxb	PROTEIN CEREBLON (Homo sapiens)	no annotation	5	ASN Z 351 PRO Z 352 TRP Z 380 TRP Z 386 TRP Z 400	85C Z 502 (-3.6A) 85C Z 502 (-4.4A) 85C Z 502 (-3.2A) 85C Z 502 (-3.4A) 85C Z 502 (-3.7A)	0.73A	4v30C-5hxbZ: 10.6	4v30C-5hxbZ: 16.50

[["4V30_C_LVYC151_1","3ln3","Mus musculus","DIHYDRODIOL DEHYDROGENASE","PF00248(Aldo_ket_red)",4,"ASN A 127;PRO A 130;TRP A  86;TYR A  53","None;MLY A 123 ( 4.7A);None;MLY A 105 ( 3.5A)","1.48A","4v30C-3ln3A:0.0","4v30C-3ln3A:17.52"],["4V30_C_LVYC151_1","4ci2","Gallus gallus","PROTEIN CEREBLON","PF02190(LON_substr_bdg);PF03226(Yippee-Mis18)",5,"ASN B 353;PRO B 354;TRP B 382;TRP B 388;TRP B 402","LVY B1429 (-4.1A);LVY B1429 (-4.7A);LVY B1429 (-3.1A);LVY B1429 (-3.5A);LVY B1429 (-3.7A)","0.58A","4v30C-4ci2B:14.5","4v30C-4ci2B:16.01"],["4V30_C_LVYC151_1","4l7a","Bacteroides caccae","UNCHARACTERIZED PROTEIN","PF15890(Peptidase_Mx1)",4,"ASN A  59;PRO A  60;TRP A  52;TYR A 297","None","1.36A","4v30C-4l7aA:0.0","4v30C-4l7aA:17.95"],["4V30_C_LVYC151_1","5hxb","Homo sapiens","PROTEIN CEREBLON","no annotation",5,"ASN Z 351;PRO Z 352;TRP Z 380;TRP Z 386;TRP Z 400","85C Z 502 (-3.6A);85C Z 502 (-4.4A);85C Z 502 (-3.2A);85C Z 502 (-3.4A);85C Z 502 (-3.7A)","0.73A","4v30C-5hxbZ:10.6","4v30C-5hxbZ:16.50"]]