SIMILAR PATTERNS OF AMINO ACIDS FOR 4V2Z_C_Y70C151_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey2 HOMOGENTISATE
1,2-DIOXYGENASE

(Homo sapiens) 		PF04209
(HgmA) 		4 ASN A 247
PHE A  73
PHE A 147
TYR A 243
 None
 1.39A 4v2zC-1ey2A:
0.0		 4v2zC-1ey2A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j32 ASPARTATE
AMINOTRANSFERASE

(Phormidium
lapideum) 		PF00155
(Aminotran_1_2) 		4 ASN A 174
PRO A 175
PHE A 325
TYR A 366
 PLP  A 413 (-3.7A)
None
None
None
 1.49A 4v2zC-1j32A:
0.0		 4v2zC-1j32A:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5s URONATE ISOMERASE

(Thermotoga
maritima) 		PF02614
(UxaC) 		4 PRO A 179
PHE A 222
PHE A 276
TRP A 285
 None
 1.39A 4v2zC-1j5sA:
undetectable		 4v2zC-1j5sA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		4 ASN A 102
PRO A 103
PHE A 101
TYR A 448
 SO4  A 602 (-3.5A)
None
None
None
 1.41A 4v2zC-1kzhA:
0.0		 4v2zC-1kzhA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		4 ASN A 149
PRO A 150
PHE A 181
TYR A 283
 None
None
PLP  A 400 (-4.3A)
None
 1.42A 4v2zC-1n8pA:
undetectable		 4v2zC-1n8pA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub1 ATTACHMENT REGION
BINDING PROTEIN

(Gallus gallus) 		PF01429
(MBD) 		4 ASN A 127
PRO A 128
PHE A 133
TRP A 105
 None
 1.01A 4v2zC-1ub1A:
undetectable		 4v2zC-1ub1A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 ASN A 105
PHE A 103
TRP A 189
TYR A  33
 None
 1.30A 4v2zC-1ukcA:
0.0		 4v2zC-1ukcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01547
(SBP_bac_1) 		4 ASN A  69
PHE A  75
TRP A  37
TRP A  35
 None
 1.16A 4v2zC-1urdA:
undetectable		 4v2zC-1urdA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 PRO A 192
PHE A 109
PHE A  95
TYR A  79
 None
 1.39A 4v2zC-2bxyA:
0.0		 4v2zC-2bxyA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw2 SUPEROXIDE DISMUTASE
1

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ASN A  85
PHE A 191
PHE A  84
TYR A 183
 None
 1.17A 4v2zC-2cw2A:
0.0		 4v2zC-2cw2A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g6y GREEN FLUORESCENT
PROTEIN 2

(Pontellina
plumata) 		PF01353
(GFP) 		4 ASN A  85
PHE A 101
PHE A  74
TYR A 105
 None
CR2  A  58 ( 4.3A)
None
None
 1.47A 4v2zC-2g6yA:
undetectable		 4v2zC-2g6yA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8g CAPSID

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 299
PHE A 636
TRP A 617
TYR A 343
 None
 1.49A 4v2zC-2g8gA:
undetectable		 4v2zC-2g8gA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 PRO A 171
PHE A 145
PHE A 351
TRP A 366
 None
 1.28A 4v2zC-2o0rA:
undetectable		 4v2zC-2o0rA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2orz NEUROPILIN-1

(Rattus
norvegicus) 		PF00754
(F5_F8_type_C) 		4 PHE A 561
TRP A 526
TRP A 484
TYR A 565
 None
 1.10A 4v2zC-2orzA:
undetectable		 4v2zC-2orzA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME

(Burkholderia
pseudomallei) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A  16
PRO A  15
PHE A  35
TRP A 354
 None
 1.20A 4v2zC-2podA:
undetectable		 4v2zC-2podA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmx PREPHENATE
DEHYDRATASE

(Chlorobaculum
tepidum) 		PF00800
(PDT) 		4 ASN A  62
PRO A  50
PHE A 173
TYR A 275
 None
 1.41A 4v2zC-2qmxA:
undetectable		 4v2zC-2qmxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqm NEUROPILIN-1

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 PHE A 561
TRP A 526
TRP A 484
TYR A 565
 None
 1.14A 4v2zC-2qqmA:
undetectable		 4v2zC-2qqmA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		4 ASN A 249
PRO A 254
PHE A 255
TYR A  65
 None
 1.44A 4v2zC-2rebA:
undetectable		 4v2zC-2rebA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		4 ASN A 213
PRO A 209
PHE A 214
TRP A 205
 None
None
None
ACH  A   1 (-3.4A)
 1.42A 4v2zC-2rinA:
undetectable		 4v2zC-2rinA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzz N-METHYL-L-TRYPTOPHA
N OXIDASE

(Escherichia
coli) 		PF01266
(DAO) 		4 PHE A 340
TRP A  71
TRP A 155
TYR A  20
 FAD  A1373 (-4.8A)
None
None
None
 1.18A 4v2zC-2uzzA:
undetectable		 4v2zC-2uzzA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ASN A 141
PRO A 145
PHE A 189
TYR A 155
 None
 1.16A 4v2zC-2w61A:
undetectable		 4v2zC-2w61A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		4 ASN A 141
PRO A 145
PHE A 189
TYR A 213
 None
 1.19A 4v2zC-2w61A:
undetectable		 4v2zC-2w61A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvq NOTI RESTRICTION
ENDONUCLEASE

(Nocardia
otitidiscaviarum) 		PF12183
(NotI) 		4 PHE A  90
PHE A  44
TRP A 161
TYR A 137
 None
 1.22A 4v2zC-3bvqA:
undetectable		 4v2zC-3bvqA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 ASN A 829
PRO A 828
PHE A 833
TRP A 871
 None
 1.09A 4v2zC-3hmjA:
undetectable		 4v2zC-3hmjA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hol TBPB

(Actinobacillus
pleuropneumoniae) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 PHE A 450
PHE A 441
TRP A 401
TRP A 411
 None
 1.48A 4v2zC-3holA:
undetectable		 4v2zC-3holA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2j PROTEIN VP1
PROTEIN VP2

(Enterovirus B) 		PF00073
(Rhv) 		4 ASN A 132
PHE A 133
PHE A  48
TYR C 176
 None
 1.35A 4v2zC-3j2jA:
undetectable		 4v2zC-3j2jA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 ASN A 264
PHE A 226
TRP A 225
TYR A 247
 None
 1.40A 4v2zC-3js8A:
undetectable		 4v2zC-3js8A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9t PUTATIVE PEPTIDASE

(Clostridium
acetobutylicum) 		PF09940
(DUF2172)
PF16221
(HTH_47)
PF16254
(DUF4910) 		4 ASN A  92
PRO A 190
PHE A  88
TRP A  70
 None
 1.50A 4v2zC-3k9tA:
undetectable		 4v2zC-3k9tA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		4 ASN A  52
PRO A  51
PHE A  95
PHE A  13
 None
 1.49A 4v2zC-3la8A:
undetectable		 4v2zC-3la8A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg3 ORANGE
CAROTENOID-BINDING
PROTEIN

(Synechocystis
sp. PCC 6803) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 PRO A 226
PHE A 240
TRP A 288
TYR A 201
 GOL  A 326 (-3.8A)
ECH  A 351 (-4.0A)
ECH  A 351 (-3.8A)
ECH  A 351 (-4.5A)
 1.31A 4v2zC-3mg3A:
undetectable		 4v2zC-3mg3A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		4 PRO A  50
PHE A  89
TRP A  99
TRP A 101
 None
 1.39A 4v2zC-3nixA:
undetectable		 4v2zC-3nixA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		4 ASN A 133
PHE A 152
PHE A 132
TRP A 131
 None
 1.49A 4v2zC-3o65A:
undetectable		 4v2zC-3o65A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odg XANTHOSINE
PHOSPHORYLASE

(Yersinia
pseudotuberculosis) 		PF01048
(PNP_UDP_1) 		4 ASN A 107
PRO A 108
PHE A  14
PHE A  65
 None
 1.38A 4v2zC-3odgA:
undetectable		 4v2zC-3odgA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3of5 DETHIOBIOTIN
SYNTHETASE

(Francisella
tularensis) 		PF13500
(AAA_26) 		4 PRO A  38
PHE A   5
PHE A  99
TYR A 104
 None
 1.46A 4v2zC-3of5A:
undetectable		 4v2zC-3of5A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os7 GALACTOSE
MUTAROTASE-LIKE
PROTEIN

(Clostridium
acetobutylicum) 		PF01263
(Aldose_epim) 		4 ASN A 310
PRO A 309
PHE A 320
TYR A 284
 None
PG4  A 400 ( 4.9A)
None
PG4  A 344 (-4.4A)
 1.43A 4v2zC-3os7A:
undetectable		 4v2zC-3os7A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shm CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 309
PHE A 638
TRP A 619
TYR A 353
 None
 1.46A 4v2zC-3shmA:
undetectable		 4v2zC-3shmA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux1 CAPSID PROTEIN VP1

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 PRO A 310
PHE A 638
TRP A 619
TYR A 354
 None
 1.45A 4v2zC-3ux1A:
undetectable		 4v2zC-3ux1A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 ASN A 338
PRO A 339
PHE A 344
TYR A 423
 None
 0.98A 4v2zC-4aeeA:
undetectable		 4v2zC-4aeeA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aut DECAPRENYL-PHOSPHORY
L-BETA-D-RIBOFURANOS
E-2-OXIDOREDUCTASE

(Mycolicibacterium
smegmatis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 ASN A 392
PHE A 376
PHE A 344
TYR A 438
 None
 1.33A 4v2zC-4autA:
undetectable		 4v2zC-4autA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 ASN A 317
PRO A 274
PHE A 319
TYR A  49
 None
IOD  A1704 ( 4.6A)
None
None
 0.93A 4v2zC-4aw7A:
undetectable		 4v2zC-4aw7A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		5 ASN B 353
PRO B 354
TRP B 382
TRP B 388
TRP B 402
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
 0.62A 4v2zC-4ci2B:
14.7		 4v2zC-4ci2B:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epp POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Tetrahymena
thermophila) 		PF05028
(PARG_cat) 		4 ASN A 431
PRO A 430
PHE A 336
TYR A 204
 None
 1.44A 4v2zC-4eppA:
undetectable		 4v2zC-4eppA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iov CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 PRO A 299
PHE A 635
TRP A 616
TYR A 343
 None
 1.44A 4v2zC-4iovA:
undetectable		 4v2zC-4iovA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.49A 4v2zC-4issA:
undetectable		 4v2zC-4issA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw5 OXIDOREDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		4 ASN A 385
PHE A 369
PHE A 337
TYR A 431
 1W6  A 502 ( 4.3A)
None
None
None
 1.34A 4v2zC-4kw5A:
undetectable		 4v2zC-4kw5A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 ASN A 250
PRO A 255
PHE A 256
TYR A  66
 None
None
None
EDO  A 402 (-4.8A)
 1.37A 4v2zC-4oqfA:
undetectable		 4v2zC-4oqfA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		4 PRO A 281
PHE A  15
PHE A 280
TYR A 177
 None
 1.44A 4v2zC-4p9nA:
undetectable		 4v2zC-4p9nA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptf DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASN A 503
PRO A 504
PHE A 494
TYR A 265
 None
 1.18A 4v2zC-4ptfA:
undetectable		 4v2zC-4ptfA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		4 PRO A 209
PHE A 251
PHE A 176
TRP A 206
 None
 1.49A 4v2zC-4s1aA:
undetectable		 4v2zC-4s1aA:
22.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 8 ASN A  50
PRO A  51
PHE A  56
PHE A  77
TRP A  79
TRP A  85
TRP A  99
TYR A 101
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
None
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
LVY  A 151 (-4.7A)
 0.76A 4v2zC-4v30A:
19.9		 4v2zC-4v30A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN

(Homo sapiens) 		PF07686
(V-set) 		4 ASN B  56
PRO B  78
PHE B  76
TYR B 131
 None
 1.35A 4v2zC-4z0xB:
undetectable		 4v2zC-4z0xB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7x MDBA

(Actinomyces
oris) 		PF13462
(Thioredoxin_4) 		4 PHE A 135
PHE A 198
TRP A 113
TYR A 115
 None
None
None
3CX  A 501 (-4.6A)
 1.23A 4v2zC-4z7xA:
undetectable		 4v2zC-4z7xA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8n RETICULOCYTE-BINDING
PROTEIN 2A

(Plasmodium
vivax) 		no annotation 4 ASN A 415
PHE A 416
PHE A 411
TYR A 308
 None
 1.48A 4v2zC-4z8nA:
undetectable		 4v2zC-4z8nA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 PRO A 244
PHE A 267
PHE A 183
TYR A 351
 None
 1.24A 4v2zC-5bqnA:
undetectable		 4v2zC-5bqnA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dld UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Burkholderia
vietnamiensis) 		PF02350
(Epimerase_2) 		4 ASN A 251
PRO A 250
PHE A 219
TYR A 244
 None
UD1  A 502 (-4.6A)
None
None
 1.36A 4v2zC-5dldA:
undetectable		 4v2zC-5dldA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		4 ASN A 226
PRO A 227
PHE A 224
TYR A 403
 None
 1.44A 4v2zC-5e3xA:
undetectable		 4v2zC-5e3xA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)

(Nostoc sp. PCC
7120) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 PRO A 228
PHE A 242
TRP A 290
TYR A 203
 45D  A 501 ( 4.5A)
45D  A 501 ( 4.0A)
45D  A 501 (-3.4A)
45D  A 501 (-4.6A)
 1.32A 4v2zC-5hgrA:
undetectable		 4v2zC-5hgrA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqj PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR

(Paraburkholderia
graminis) 		PF13407
(Peripla_BP_4) 		4 PRO A  67
PHE A  44
TRP A  64
TYR A  62
 None
64K  A 401 ( 4.2A)
None
None
 1.04A 4v2zC-5hqjA:
undetectable		 4v2zC-5hqjA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 ASN Z 351
PRO Z 352
TRP Z 380
TRP Z 400
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.7A)
 0.77A 4v2zC-5hxbZ:
10.7		 4v2zC-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 PRO Z 352
TRP Z 380
TRP Z 386
TRP Z 400
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
 0.51A 4v2zC-5hxbZ:
10.7		 4v2zC-5hxbZ:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 ASN A 859
PRO A 860
PHE A 849
TYR A1112
 None
 0.92A 4v2zC-5hzrA:
undetectable		 4v2zC-5hzrA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASN A 324
PRO A 325
PHE A 320
TYR A 314
 None
 1.49A 4v2zC-5i8iA:
undetectable		 4v2zC-5i8iA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A  69
PHE A  70
TRP A 350
TYR A 932
 None
 1.45A 4v2zC-5ihrA:
undetectable		 4v2zC-5ihrA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PRO A  69
PHE A 121
PHE A  70
TYR A 109
 None
 1.45A 4v2zC-5ihrA:
undetectable		 4v2zC-5ihrA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00567
(TUDOR) 		4 ASN A 319
PHE A 321
TRP A 466
TRP A 322
 UNX  A 504 ( 3.8A)
None
None
None
 1.37A 4v2zC-5j39A:
undetectable		 4v2zC-5j39A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 PHE A 713
PHE A 691
TRP A 629
TYR A 728
 None
 1.49A 4v2zC-5kd5A:
undetectable		 4v2zC-5kd5A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 ASN B 440
PRO B 460
PHE B 459
TYR B 313
 None
 1.38A 4v2zC-5kohB:
undetectable		 4v2zC-5kohB:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 4 ASN A 377
PRO A 378
TRP A 374
TYR A  56
 None
None
EDO  A 709 (-4.6A)
EDO  A 709 (-4.4A)
 1.17A 4v2zC-5ta1A:
undetectable		 4v2zC-5ta1A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 ASN A 194
PRO A 193
PHE A 197
TYR A 315
 None
 1.47A 4v2zC-5u47A:
undetectable		 4v2zC-5u47A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ui2 ORANGE
CAROTENOID-BINDING
PROTEIN

(Arthrospira
maxima) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 PRO A 228
PHE A 242
TRP A 290
TYR A 203
 None
None
EQ3  A 403 (-4.2A)
EQ3  A 403 (-4.6A)
 1.30A 4v2zC-5ui2A:
undetectable		 4v2zC-5ui2A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6s ACETYLXYLAN ESTERASE
A

(Aspergillus
awamori) 		PF10503
(Esterase_phd) 		4 ASN A  13
PRO A  14
PHE A  10
TYR A 132
 None
 1.41A 4v2zC-5x6sA:
undetectable		 4v2zC-5x6sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7y ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ARYL HYDROCARBON
RECEPTOR REPRESSOR

(Bos taurus;
Homo sapiens) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		4 ASN B 448
PRO B 449
PHE B 446
TRP A 177
 None
 1.34A 4v2zC-5y7yB:
undetectable		 4v2zC-5y7yB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbd PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D

(Sus scrofa) 		no annotation 4 ASN A 236
PRO A 235
PHE A 234
TYR A 228
 None
 1.18A 4v2zC-6bbdA:
undetectable		 4v2zC-6bbdA:
20.69