SIMILAR PATTERNS OF AMINO ACIDS FOR 4V2Y_C_EF2C151
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j32 | ASPARTATEAMINOTRANSFERASE (Phormidiumlapideum) |
PF00155(Aminotran_1_2) | 4 | ASN A 174PRO A 175PHE A 325TYR A 366 | PLP A 413 (-3.7A)NoneNoneNone | 1.49A | 4v2yC-1j32A:0.0 | 4v2yC-1j32A:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukc | ESTA (Aspergillusniger) |
PF00135(COesterase) | 4 | ASN A 105PHE A 103TRP A 189TYR A 33 | None | 1.31A | 4v2yC-1ukcA:undetectable | 4v2yC-1ukcA:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qmx | PREPHENATEDEHYDRATASE (Chlorobaculumtepidum) |
PF00800(PDT) | 4 | ASN A 62PRO A 50PHE A 173TYR A 275 | None | 1.40A | 4v2yC-2qmxA:0.0 | 4v2yC-2qmxA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2reb | REC A (Escherichiacoli) |
PF00154(RecA) | 4 | ASN A 249PRO A 254PHE A 255TYR A 65 | None | 1.39A | 4v2yC-2rebA:0.0 | 4v2yC-2rebA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w61 | GLYCOLIPID-ANCHOREDSURFACE PROTEIN 2 (Saccharomycescerevisiae) |
PF03198(Glyco_hydro_72)PF07983(X8) | 4 | ASN A 141PRO A 145PHE A 189TYR A 155 | None | 1.14A | 4v2yC-2w61A:0.0 | 4v2yC-2w61A:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w61 | GLYCOLIPID-ANCHOREDSURFACE PROTEIN 2 (Saccharomycescerevisiae) |
PF03198(Glyco_hydro_72)PF07983(X8) | 4 | ASN A 141PRO A 145PHE A 189TYR A 213 | None | 1.18A | 4v2yC-2w61A:0.0 | 4v2yC-2w61A:10.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cmv | PROTEIN RECA (Escherichiacoli) |
PF00154(RecA) | 4 | ASN A1249PRO A1254PHE A1255TYR A1065 | None | 1.49A | 4v2yC-3cmvA:undetectable | 4v2yC-3cmvA:6.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3js8 | CHOLESTEROL OXIDASE (Chromobacteriumsp. DS-1) |
PF01565(FAD_binding_4)PF09129(Chol_subst-bind) | 4 | ASN A 264PHE A 226TRP A 225TYR A 247 | None | 1.38A | 4v2yC-3js8A:0.0 | 4v2yC-3js8A:14.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nix | FLAVOPROTEIN/DEHYDROGENASE (Cytophagahutchinsonii) |
PF01494(FAD_binding_3) | 4 | PRO A 50PHE A 89TRP A 99TRP A 101 | None | 1.40A | 4v2yC-3nixA:0.0 | 4v2yC-3nixA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3opw | DNADAMAGE-RESPONSIVETRANSCRIPTIONALREPRESSOR RPH1 (Saccharomycescerevisiae) |
PF02373(JmjC)PF02375(JmjN) | 4 | ASN A 200PHE A 27TRP A 52TYR A 21 | None | 1.34A | 4v2yC-3opwA:undetectable | 4v2yC-3opwA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os7 | GALACTOSEMUTAROTASE-LIKEPROTEIN (Clostridiumacetobutylicum) |
PF01263(Aldose_epim) | 4 | ASN A 310PRO A 309PHE A 320TYR A 284 | NonePG4 A 400 ( 4.9A)NonePG4 A 344 (-4.4A) | 1.45A | 4v2yC-3os7A:undetectable | 4v2yC-3os7A:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3shm | CAPSID PROTEIN VP1 (Adeno-associateddependoparvovirusA) |
PF00740(Parvo_coat) | 4 | PRO A 309PHE A 638TRP A 619TYR A 353 | None | 1.49A | 4v2yC-3shmA:undetectable | 4v2yC-3shmA:13.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ux1 | CAPSID PROTEIN VP1 (Adeno-associateddependoparvovirusA) |
PF00740(Parvo_coat) | 4 | PRO A 310PHE A 638TRP A 619TYR A 354 | None | 1.48A | 4v2yC-3ux1A:undetectable | 4v2yC-3ux1A:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aee | ALPHA AMYLASE,CATALYTIC REGION (Staphylothermusmarinus) |
PF00128(Alpha-amylase) | 4 | ASN A 338PRO A 339PHE A 344TYR A 423 | None | 0.96A | 4v2yC-4aeeA:undetectable | 4v2yC-4aeeA:10.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aw7 | GH86ABETA-PORPHYRANASE (Bacteroidesplebeius) |
no annotation | 4 | ASN A 317PRO A 274PHE A 319TYR A 49 | NoneIOD A1704 ( 4.6A)NoneNone | 0.94A | 4v2yC-4aw7A:undetectable | 4v2yC-4aw7A:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci2 | PROTEIN CEREBLON (Gallus gallus) |
PF02190(LON_substr_bdg)PF03226(Yippee-Mis18) | 5 | ASN B 353PRO B 354TRP B 382TRP B 388TRP B 402 | LVY B1429 (-4.1A)LVY B1429 (-4.7A)LVY B1429 (-3.1A)LVY B1429 (-3.5A)LVY B1429 (-3.7A) | 0.66A | 4v2yC-4ci2B:14.9 | 4v2yC-4ci2B:16.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4epp | POLY(ADP-RIBOSE)GLYCOHYDROLASE (Tetrahymenathermophila) |
PF05028(PARG_cat) | 4 | ASN A 431PRO A 430PHE A 336TYR A 204 | None | 1.41A | 4v2yC-4eppA:undetectable | 4v2yC-4eppA:12.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iov | CAPSID PROTEIN VP1 (Adeno-associatedvirus) |
PF00740(Parvo_coat) | 4 | PRO A 299PHE A 635TRP A 616TYR A 343 | None | 1.46A | 4v2yC-4iovA:undetectable | 4v2yC-4iovA:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iss | ALLOPHANATEHYDROLASE (Kluyveromyceslactis) |
PF01425(Amidase) | 4 | ASN A 324PRO A 325PHE A 320TYR A 314 | None | 1.45A | 4v2yC-4issA:undetectable | 4v2yC-4issA:9.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oqf | PROTEIN RECA (Mycobacteriumtuberculosis) |
PF00154(RecA) | 4 | ASN A 250PRO A 255PHE A 256TYR A 66 | NoneNoneNoneEDO A 402 (-4.8A) | 1.32A | 4v2yC-4oqfA:undetectable | 4v2yC-4oqfA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ptf | DNA POLYMERASEEPSILON CATALYTICSUBUNIT A (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 4 | ASN A 503PRO A 504PHE A 494TYR A 265 | None | 1.15A | 4v2yC-4ptfA:undetectable | 4v2yC-4ptfA:7.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4v30 | CEREBLON ISOFORM 4 (Magnetospirillumgryphiswaldense) |
no annotation | 7 | ASN A 50PRO A 51PHE A 77TRP A 79TRP A 85TRP A 99TYR A 101 | LVY A 151 (-3.8A)LVY A 151 (-4.4A)LVY A 151 (-4.4A)LVY A 151 (-3.2A)LVY A 151 (-3.4A)LVY A 151 (-3.7A)LVY A 151 (-4.7A) | 0.74A | 4v2yC-4v30A:20.0 | 4v2yC-4v30A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0x | ANTIBODY HC26AMHEAVY CHAIN VARIABLEDOMAIN (Homo sapiens) |
PF07686(V-set) | 4 | ASN B 56PRO B 78PHE B 76TYR B 131 | None | 1.36A | 4v2yC-4z0xB:undetectable | 4v2yC-4z0xB:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxb | PROTEIN CEREBLON (Homo sapiens) |
no annotation | 4 | ASN Z 351PRO Z 352TRP Z 380TRP Z 400 | 85C Z 502 (-3.6A)85C Z 502 (-4.4A)85C Z 502 (-3.2A)85C Z 502 (-3.7A) | 0.78A | 4v2yC-5hxbZ:10.9 | 4v2yC-5hxbZ:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hxb | PROTEIN CEREBLON (Homo sapiens) |
no annotation | 4 | PRO Z 352TRP Z 380TRP Z 386TRP Z 400 | 85C Z 502 (-4.4A)85C Z 502 (-3.2A)85C Z 502 (-3.4A)85C Z 502 (-3.7A) | 0.57A | 4v2yC-5hxbZ:10.9 | 4v2yC-5hxbZ:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8i | UREA AMIDOLYASE (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF01425(Amidase)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 4 | ASN A 324PRO A 325PHE A 320TYR A 314 | None | 1.45A | 4v2yC-5i8iA:undetectable | 4v2yC-5i8iA:5.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihr | PROBABLEBETA-GALACTOSIDASE A (Aspergillusniger) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 4 | PRO A 69PHE A 70TRP A 350TYR A 932 | None | 1.43A | 4v2yC-5ihrA:undetectable | 4v2yC-5ihrA:9.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5koh | NITROGENASE FEMOBETA SUBUNIT PROTEINNIFK (Gluconacetobacterdiazotrophicus) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 4 | ASN B 440PRO B 460PHE B 459TYR B 313 | None | 1.38A | 4v2yC-5kohB:undetectable | 4v2yC-5kohB:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ta1 | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
no annotation | 4 | ASN A 377PRO A 378TRP A 374TYR A 56 | NoneNoneEDO A 709 (-4.6A)EDO A 709 (-4.4A) | 1.16A | 4v2yC-5ta1A:undetectable | 4v2yC-5ta1A:12.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z5d | BETA-XYLOSIDASE (Geobacillusthermoleovorans) |
no annotation | 4 | ASN A 445PRO A 446PHE A 371TYR A 507 | NoneGOL A 605 (-4.5A)GOL A 605 (-3.6A)None | 1.30A | 4v2yC-5z5dA:undetectable | 4v2yC-5z5dA:20.00 |