SIMILAR PATTERNS OF AMINO ACIDS FOR 4V2O_C_CLQC1079

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh2 N UTILIZATION
SUBSTANCE PROTEIN A

(Thermotoga
maritima) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		4 ARG P 227
MET P 208
GLU P 264
LEU P 265
 None
 1.24A 4v2oA-1hh2P:
1.2
4v2oC-1hh2P:
1.2		 4v2oA-1hh2P:
13.27
4v2oC-1hh2P:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf7 CLASS B ACID
PHOSPHATASE

(Escherichia
coli) 		PF03767
(Acid_phosphat_B) 		4 ARG A 181
MET A 100
GLU A  30
LEU A  33
 None
 1.39A 4v2oA-2hf7A:
0.0
4v2oC-2hf7A:
0.0		 4v2oA-2hf7A:
15.69
4v2oC-2hf7A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE

(Paenarthrobacter
nicotinovorans) 		PF06500
(DUF1100) 		4 ARG A 130
MET A  73
GLU A  70
LEU A 109
 None
 1.36A 4v2oA-2jbwA:
1.4
4v2oC-2jbwA:
undetectable		 4v2oA-2jbwA:
12.11
4v2oC-2jbwA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k42 WISKOTT-ALDRICH
SYNDROME PROTEIN
ESPFU

(Homo sapiens;
Escherichia
coli) 		PF00786
(PBD)
PF04806
(EspF) 		4 ARG A  35
MET B  84
GLU A  68
LEU A  32
 None
 1.34A 4v2oA-2k42A:
undetectable
4v2oC-2k42A:
undetectable		 4v2oA-2k42A:
20.25
4v2oC-2k42A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 MET A 230
MET A 233
GLU A 234
LEU A 191
 None
 1.45A 4v2oA-2wnwA:
undetectable
4v2oC-2wnwA:
undetectable		 4v2oA-2wnwA:
11.76
4v2oC-2wnwA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		4 ARG A 286
MET A 304
GLU A 277
LEU A 278
 None
 1.45A 4v2oA-2xfsA:
0.0
4v2oC-2xfsA:
0.0		 4v2oA-2xfsA:
12.43
4v2oC-2xfsA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 ARG A 214
MET A 162
GLU A 166
LEU A 284
 None
 1.48A 4v2oA-3cwgA:
1.7
4v2oC-3cwgA:
1.4		 4v2oA-3cwgA:
8.54
4v2oC-3cwgA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fy4 6-4 PHOTOLYASE

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ARG A  64
MET A  44
GLU A 211
LEU A 202
 None
 1.48A 4v2oA-3fy4A:
0.0
4v2oC-3fy4A:
0.0		 4v2oA-3fy4A:
9.39
4v2oC-3fy4A:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 ARG A 259
MET A 170
MET A 213
LEU A 260
 None
 1.42A 4v2oA-3jb9A:
undetectable
4v2oC-3jb9A:
0.0		 4v2oA-3jb9A:
2.91
4v2oC-3jb9A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtl PROTEASOME SUBUNIT
BETA

(Thermoplasma
acidophilum) 		PF00227
(Proteasome) 		4 ARG H 157
MET H 146
GLU H 150
LEU H 154
 None
 1.33A 4v2oA-3jtlH:
0.8
4v2oC-3jtlH:
0.8		 4v2oA-3jtlH:
17.53
4v2oC-3jtlH:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Listeria
monocytogenes) 		PF00275
(EPSP_synthase) 		4 ARG A 105
MET A 202
GLU A 221
LEU A 176
 None
 1.42A 4v2oA-3r38A:
undetectable
4v2oC-3r38A:
undetectable		 4v2oA-3r38A:
12.06
4v2oC-3r38A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 4 ARG A 464
MET A 453
GLU A 457
LEU A 461
 None
 1.39A 4v2oA-4btpA:
1.5
4v2oC-4btpA:
0.4		 4v2oA-4btpA:
7.57
4v2oC-4btpA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 ARG A 855
MET A 858
GLU A 613
LEU A 614
 None
 1.37A 4v2oA-4czwA:
undetectable
4v2oC-4czwA:
undetectable		 4v2oA-4czwA:
8.59
4v2oC-4czwA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcv NADP-DEPENDENT
2-HYDROXYACID
DEHYDROGENASE

(Rhizobium etli) 		PF02826
(2-Hacid_dh_C) 		4 ARG A 115
MET A 161
GLU A 136
LEU A 114
 None
 1.32A 4v2oA-4xcvA:
undetectable
4v2oC-4xcvA:
undetectable		 4v2oA-4xcvA:
17.10
4v2oC-4xcvA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c70 GLUCURONIDASE

(Aspergillus
oryzae) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 MET A 530
MET A 533
GLU A 483
LEU A 486
 None
 1.33A 4v2oA-5c70A:
undetectable
4v2oC-5c70A:
undetectable		 4v2oA-5c70A:
7.84
4v2oC-5c70A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ARG B 341
MET B 204
GLU B 209
LEU B 210
 None
 1.15A 4v2oA-5n8nB:
undetectable
4v2oC-5n8nB:
undetectable		 4v2oA-5n8nB:
undetectable
4v2oC-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9g GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 ARG A 338
MET A 326
GLU A 794
LEU A 817
 EDO  A 903 (-4.2A)
None
None
None
 1.44A 4v2oA-5t9gA:
undetectable
4v2oC-5t9gA:
undetectable		 4v2oA-5t9gA:
8.08
4v2oC-5t9gA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unn NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE

(Sinorhizobium
meliloti) 		PF02826
(2-Hacid_dh_C) 		4 ARG A 115
MET A 161
GLU A 136
LEU A 114
 None
 1.30A 4v2oA-5unnA:
undetectable
4v2oC-5unnA:
undetectable		 4v2oA-5unnA:
12.46
4v2oC-5unnA:
12.46