SIMILAR PATTERNS OF AMINO ACIDS FOR 4V2O_B_CLQB1079

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 MET A 114
GLU A 118
LEU A 122
 None
 0.54A 4v2oB-1bvuA:
0.0		 4v2oB-1bvuA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cks CYCLIN-DEPENDENT
KINASE SUBUNIT, TYPE
2

(Homo sapiens) 		PF01111
(CKS) 		3 MET A  38
GLU A  42
LEU A  46
 None
 0.72A 4v2oB-1cksA:
undetectable		 4v2oB-1cksA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e59 PHOSPHOGLYCERATE
MUTASE

(Escherichia
coli) 		PF00300
(His_Phos_1) 		3 MET A 197
GLU A 201
LEU A 205
 None
 0.80A 4v2oB-1e59A:
0.0		 4v2oB-1e59A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exx RETINOIC ACID
RECEPTOR GAMMA-2

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 MET A 323
GLU A 327
LEU A 331
 None
 0.48A 4v2oB-1exxA:
1.2		 4v2oB-1exxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD

(Homo sapiens) 		PF00076
(RRM_1) 		3 MET A  50
GLU A  54
LEU A  58
 None
 0.81A 4v2oB-1fxlA:
undetectable		 4v2oB-1fxlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxl PARANEOPLASTIC
ENCEPHALOMYELITIS
ANTIGEN HUD

(Homo sapiens) 		PF00076
(RRM_1) 		3 MET A 136
GLU A 140
LEU A 144
 None
 0.79A 4v2oB-1fxlA:
undetectable		 4v2oB-1fxlA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 MET A  26
GLU A  30
LEU A  34
 None
 0.76A 4v2oB-1khdA:
0.0		 4v2oB-1khdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		3 MET A   1
GLU A   5
LEU A   9
 None
 0.80A 4v2oB-1nmoA:
undetectable		 4v2oB-1nmoA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		3 MET A 175
GLU A 197
LEU A 398
 None
 0.75A 4v2oB-1v6cA:
0.0		 4v2oB-1v6cA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xap RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 MET A 314
GLU A 318
LEU A 322
 None
 0.34A 4v2oB-1xapA:
1.0		 4v2oB-1xapA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdk RETINOIC ACID
RECEPTOR, BETA

(Mus musculus) 		PF00104
(Hormone_recep) 		3 MET B 314
GLU B 318
LEU B 322
 None
 0.50A 4v2oB-1xdkB:
0.0		 4v2oB-1xdkB:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		3 MET A 536
GLU A 540
LEU A 544
 None
 0.59A 4v2oB-1xf1A:
undetectable		 4v2oB-1xf1A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzh CYTOCHROME C
PEROXIDASE

(Rhodobacter
capsulatus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 MET A 184
GLU A 188
LEU A 192
 None
 0.53A 4v2oB-1zzhA:
0.0		 4v2oB-1zzhA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ast CYCLIN-DEPENDENT
KINASES REGULATORY
SUBUNIT 1

(Homo sapiens) 		PF01111
(CKS) 		3 MET C3038
GLU C3042
LEU C3046
 None
 0.76A 4v2oB-2astC:
undetectable		 4v2oB-2astC:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1u DI-HAEM CYTOCHROME C
PEROXIDASE

(Paracoccus
pantotrophus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		3 MET A 195
GLU A 199
LEU A 203
 None
 0.45A 4v2oB-2c1uA:
0.0		 4v2oB-2c1uA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2a PROTEIN (ENZYME IIA)

(Lactococcus
lactis) 		PF02255
(PTS_IIA) 		3 MET A   1
GLU A   5
LEU A   9
 None
 0.73A 4v2oB-2e2aA:
undetectable		 4v2oB-2e2aA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH

(Bacillus
subtilis) 		PF07435
(YycH) 		3 MET A 386
GLU A 390
LEU A 394
 None
 0.71A 4v2oB-2fgtA:
undetectable		 4v2oB-2fgtA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fji EXOCYST COMPLEX
COMPONENT SEC6

(Saccharomyces
cerevisiae) 		PF06046
(Sec6) 		3 MET 1 410
GLU 1 414
LEU 1 418
 None
 0.73A 4v2oB-2fji1:
undetectable		 4v2oB-2fji1:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		3 MET A   1
GLU A 228
LEU A 230
 None
 0.69A 4v2oB-2gduA:
undetectable		 4v2oB-2gduA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf4 PROTEIN VNG1086C

(Halobacterium
salinarum) 		PF01893
(UPF0058) 		3 MET A   1
GLU A   5
LEU A   9
 None
 0.59A 4v2oB-2gf4A:
undetectable		 4v2oB-2gf4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 MET A 431
GLU A 435
LEU A 439
 None
 0.75A 4v2oB-2j2mA:
undetectable		 4v2oB-2j2mA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyx PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN,
RV1404

(Mycobacterium
tuberculosis) 		PF01047
(MarR) 		3 MET A 131
GLU A 135
LEU A 139
 None
 0.37A 4v2oB-2nyxA:
undetectable		 4v2oB-2nyxA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1f PREDICTED
AMINODEOXYCHORISMATE
LYASE

(Escherichia
coli) 		PF02618
(YceG) 		3 MET A  93
GLU A  97
LEU A 101
 None
 0.76A 4v2oB-2r1fA:
undetectable		 4v2oB-2r1fA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5h SERINE/THREONINE-PRO
TEIN KINASE NEK2

(Homo sapiens) 		PF00069
(Pkinase) 		3 MET A  44
GLU A  48
LEU A  52
 None
 0.68A 4v2oB-2w5hA:
undetectable		 4v2oB-2w5hA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9j PROTEIN PRGH

(Salmonella
enterica) 		PF09480
(PrgH) 		3 MET A 267
GLU A 271
LEU A 275
 None
 0.67A 4v2oB-2y9jA:
undetectable		 4v2oB-2y9jA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsg AMINOPEPTIDASE P,
PUTATIVE

(Thermotoga
maritima) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		3 MET A 164
GLU A 168
LEU A 172
 None
 0.53A 4v2oB-2zsgA:
undetectable		 4v2oB-2zsgA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a6p EXPORTIN-5

(Homo sapiens) 		PF08389
(Xpo1) 		3 MET A  82
GLU A  86
LEU A  90
 None
 0.39A 4v2oB-3a6pA:
3.8		 4v2oB-3a6pA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		3 MET A 127
GLU A 132
LEU A 133
 None
 0.60A 4v2oB-3bujA:
undetectable		 4v2oB-3bujA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuq VACUOLAR
PROTEIN-SORTING-ASSO
CIATED PROTEIN 36

(Homo sapiens) 		PF04157
(EAP30) 		3 MET B 264
GLU B 268
LEU B 272
 None
 0.51A 4v2oB-3cuqB:
undetectable		 4v2oB-3cuqB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus) 		PF00682
(HMGL-like) 		3 MET A 101
GLU A 127
LEU A 157
 None
 0.81A 4v2oB-3dxiA:
undetectable		 4v2oB-3dxiA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3k UNCHARACTERIZED
PROTEIN YKR043C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 MET A 108
GLU A 112
LEU A 116
 None
 0.57A 4v2oB-3f3kA:
undetectable		 4v2oB-3f3kA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7p PLECTIN-1

(Homo sapiens) 		PF00307
(CH) 		3 MET A 185
GLU A 189
LEU A 193
 None
 0.44A 4v2oB-3f7pA:
undetectable		 4v2oB-3f7pA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkx PUTATIVE ARSC FAMILY
RELATED PROTEIN

(Bacteroides
fragilis) 		PF03960
(ArsC) 		3 MET A  77
GLU A  81
LEU A  85
 None
 0.31A 4v2oB-3gkxA:
undetectable		 4v2oB-3gkxA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4p PROTEASOME SUBUNIT
BETA

(Methanocaldococcus
jannaschii) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		3 MET a 155
GLU a 159
LEU a 163
 None
 0.44A 4v2oB-3h4pa:
undetectable		 4v2oB-3h4pa:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi9 ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 MET A  31
GLU A  35
LEU A  39
 None
 0.61A 4v2oB-3hi9A:
undetectable		 4v2oB-3hi9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 3 MET A  69
GLU A  73
LEU A  77
 None
 0.79A 4v2oB-3hkaA:
undetectable		 4v2oB-3hkaA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN LIGHT
POLYPEPTIDE 6

(Gallus gallus) 		PF13405
(EF-hand_6) 		3 MET C 119
GLU C 123
LEU C 127
 None
 0.66A 4v2oB-3j04C:
undetectable		 4v2oB-3j04C:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		3 MET A  15
GLU A  19
LEU A  23
 None
 0.65A 4v2oB-3j4jA:
undetectable		 4v2oB-3j4jA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		3 MET A2387
GLU A2388
LEU A2392
 None
 0.80A 4v2oB-3jbzA:
2.3		 4v2oB-3jbzA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtl PROTEASOME SUBUNIT
BETA

(Thermoplasma
acidophilum) 		PF00227
(Proteasome) 		3 MET H 146
GLU H 150
LEU H 154
 None
 0.82A 4v2oB-3jtlH:
undetectable		 4v2oB-3jtlH:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7x LIN0763 PROTEIN

(Listeria
innocua) 		PF03663
(Glyco_hydro_76) 		3 MET A   1
GLU A   5
LEU A   9
 None
 0.80A 4v2oB-3k7xA:
undetectable		 4v2oB-3k7xA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 MET A 125
GLU A 129
LEU A 133
 None
 0.38A 4v2oB-3k8zA:
undetectable		 4v2oB-3k8zA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 MET A 126
GLU A 130
LEU A 134
 None
 0.36A 4v2oB-3k92A:
undetectable		 4v2oB-3k92A:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn3 PUTATIVE PERIPLASMIC
PROTEIN

(Wolinella
succinogenes) 		PF12849
(PBP_like_2) 		3 MET A  98
GLU A 102
LEU A 106
 None
 0.68A 4v2oB-3kn3A:
undetectable		 4v2oB-3kn3A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfk MARR LIKE PROTEIN,
TVG0766549

(Thermoplasma
volcanium) 		no annotation 3 MET A  31
GLU A  35
LEU A  39
 None
 0.65A 4v2oB-3lfkA:
undetectable		 4v2oB-3lfkA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdn GLUTAMINE
AMINOTRANSFERASE
CLASS-II DOMAIN
PROTEIN

(Ruegeria
pomeroyi) 		PF13230
(GATase_4) 		3 MET A 183
GLU A 171
LEU A 170
 None
 0.73A 4v2oB-3mdnA:
undetectable		 4v2oB-3mdnA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mhx PUTATIVE FERROUS
IRON TRANSPORT
PROTEIN A

(Stenotrophomonas
maltophilia) 		PF04023
(FeoA) 		3 MET A   1
GLU A   5
LEU A   6
 None
ZN  A2002 (-2.3A)
None
 0.68A 4v2oB-3mhxA:
undetectable		 4v2oB-3mhxA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ont SPOT 14 PROTEIN

(Mus musculus) 		PF07084
(Spot_14) 		3 MET A  62
GLU A 114
LEU A 113
 None
 0.79A 4v2oB-3ontA:
undetectable		 4v2oB-3ontA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		3 MET A 329
GLU A 333
LEU A 337
 None
 0.80A 4v2oB-3pjxA:
undetectable		 4v2oB-3pjxA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r1x 2-OXO-3-DEOXYGALACTO
NATE KINASE

(Klebsiella
pneumoniae) 		PF05035
(DGOK) 		3 MET A 116
GLU A 119
LEU A 123
 None
 0.81A 4v2oB-3r1xA:
undetectable		 4v2oB-3r1xA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkr SHORT CHAIN
OXIDOREDUCTASE

(uncultured
bacterium Bio5) 		PF00106
(adh_short) 		3 MET A 103
GLU A 107
LEU A 111
 None
 0.58A 4v2oB-3rkrA:
undetectable		 4v2oB-3rkrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7j RIBOSE-5-PHOSPHATE
ISOMERASE A

(Burkholderia
thailandensis) 		PF06026
(Rib_5-P_isom_A) 		3 MET A   5
GLU A   9
LEU A  13
 None
EDO  A 239 (-4.0A)
None
 0.68A 4v2oB-3u7jA:
undetectable		 4v2oB-3u7jA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-4

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		3 MET K 151
GLU K 155
LEU K 159
 None
 0.57A 4v2oB-3wxrK:
undetectable		 4v2oB-3wxrK:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		3 MET A  56
GLU A  60
LEU A  64
 None
 0.71A 4v2oB-3zs7A:
undetectable		 4v2oB-3zs7A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		3 MET A 239
GLU A 234
LEU A 235
 None
 0.80A 4v2oB-4adeA:
undetectable		 4v2oB-4adeA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b43 TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N) 		3 MET A  15
GLU A  19
LEU A  23
 None
 0.42A 4v2oB-4b43A:
undetectable		 4v2oB-4b43A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btp P1

(Pseudomonas
phage phi8) 		no annotation 3 MET A 453
GLU A 457
LEU A 461
 None
 0.69A 4v2oB-4btpA:
undetectable		 4v2oB-4btpA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed5 ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 MET A  31
GLU A  35
LEU A  39
 None
 0.58A 4v2oB-4ed5A:
undetectable		 4v2oB-4ed5A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo9 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Mycobacterium
leprae) 		PF00300
(His_Phos_1) 		3 MET A 199
GLU A 203
LEU A 207
 None
 0.77A 4v2oB-4eo9A:
undetectable		 4v2oB-4eo9A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxv ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		3 MET A  31
GLU A  35
LEU A  39
 None
 0.64A 4v2oB-4fxvA:
undetectable		 4v2oB-4fxvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		3 MET A 422
GLU A 474
LEU A 476
 None
 0.81A 4v2oB-4gz8A:
undetectable		 4v2oB-4gz8A:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoo LYSINE-SPECIFIC
DEMETHYLASE 4D

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 MET A  96
GLU A 100
LEU A 104
 None
 0.77A 4v2oB-4hooA:
undetectable		 4v2oB-4hooA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		3 MET A 154
GLU A 158
LEU A 162
 None
 0.61A 4v2oB-4i99A:
undetectable		 4v2oB-4i99A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwg TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		3 MET A 107
GLU A 111
LEU A 115
 None
 0.78A 4v2oB-4jwgA:
undetectable		 4v2oB-4jwgA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwh TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Schizosaccharomyces
pombe) 		PF01746
(tRNA_m1G_MT) 		3 MET A 107
GLU A 111
LEU A 115
 None
 0.79A 4v2oB-4jwhA:
undetectable		 4v2oB-4jwhA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01746
(tRNA_m1G_MT) 		3 MET A 107
GLU A 111
LEU A 115
 None
 0.78A 4v2oB-4jwjA:
undetectable		 4v2oB-4jwjA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 MET A  40
GLU A  44
LEU A  48
 None
 0.67A 4v2oB-4ksaA:
undetectable		 4v2oB-4ksaA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 MET A 228
GLU A 232
LEU A 236
 None
 0.67A 4v2oB-4lk2A:
undetectable		 4v2oB-4lk2A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 MET A  93
GLU A  97
LEU A 101
 None
 0.75A 4v2oB-4lxlA:
undetectable		 4v2oB-4lxlA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwz PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE

(Plasmodium
vivax) 		PF13649
(Methyltransf_25) 		3 MET A 181
GLU A 185
LEU A 189
 None
 0.77A 4v2oB-4mwzA:
undetectable		 4v2oB-4mwzA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nko ENGINEERED SCFV
HEAVY CHAIN

(Mus musculus) 		PF07686
(V-set) 		3 MET B  81
GLU B  82
LEU B  83
 None
 0.74A 4v2oB-4nkoB:
undetectable		 4v2oB-4nkoB:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oci CALMODULIN, PUTATIVE

(Entamoeba
histolytica) 		PF00036
(EF-hand_1)
PF13833
(EF-hand_8) 		3 MET A 110
GLU A 114
LEU A 118
 None
 0.56A 4v2oB-4ociA:
undetectable		 4v2oB-4ociA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 PLECTIN

(Homo sapiens) 		PF00307
(CH) 		3 MET A 158
GLU A 162
LEU A 166
 None
 0.58A 4v2oB-4q58A:
undetectable		 4v2oB-4q58A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		3 MET A 179
GLU A 183
LEU A 187
 None
 0.52A 4v2oB-4r33A:
undetectable		 4v2oB-4r33A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 3 MET D   1
GLU D  48
LEU D  72
 None
 0.79A 4v2oB-4s1vD:
undetectable		 4v2oB-4s1vD:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u88 TRANSCRIPTIONAL
REGULATOR SAER

(Staphylococcus
aureus) 		PF00486
(Trans_reg_C) 		3 MET A 106
GLU A 110
LEU A 114
 None
 0.77A 4v2oB-4u88A:
undetectable		 4v2oB-4u88A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzb NITROGENASE
MOLYBDENUM-IRON
PROTEIN ALPHA CHAIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		3 MET A   4
GLU A   8
LEU A  12
 None
 0.71A 4v2oB-4wzbA:
undetectable		 4v2oB-4wzbA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdo LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF02373
(JmjC)
PF02375
(JmjN) 		3 MET A  94
GLU A  98
LEU A 102
 None
 0.63A 4v2oB-4xdoA:
undetectable		 4v2oB-4xdoA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN

(Salmonella
enterica) 		PF01052
(FliMN_C)
PF16973
(FliN_N) 		3 MET B 163
GLU B 167
LEU B 171
 None
 0.70A 4v2oB-4yxcB:
undetectable		 4v2oB-4yxcB:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5

(Homo sapiens) 		PF00307
(CH) 		3 MET A 161
GLU A 165
LEU A 169
 None
 0.50A 4v2oB-4z6gA:
undetectable		 4v2oB-4z6gA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aih LIMONENE-1,2-EPOXIDE
HYDROLASE

(unidentified) 		PF07858
(LEH) 		3 MET A   1
GLU A   5
LEU A   9
 None
 0.79A 4v2oB-5aihA:
undetectable		 4v2oB-5aihA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		3 MET A 136
GLU A 140
LEU A 144
 None
 0.70A 4v2oB-5eefA:
undetectable		 4v2oB-5eefA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans) 		PF00067
(p450) 		3 MET A 292
GLU A 296
LEU A 300
 None
 0.28A 4v2oB-5fsaA:
undetectable		 4v2oB-5fsaA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gn1 ATP-DEPENDENT
HELICASE FUN30

(Saccharomyces
cerevisiae) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		3 MET A 919
GLU A 923
LEU A 927
 None
 0.49A 4v2oB-5gn1A:
undetectable		 4v2oB-5gn1A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyl LEGUMIN-LIKE PROTEIN

(Cicer arietinum) 		PF00190
(Cupin_1) 		3 MET A 467
GLU A 471
LEU A 475
 None
 0.72A 4v2oB-5gylA:
undetectable		 4v2oB-5gylA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN

(Exiguobacterium
antarcticum) 		PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4) 		3 MET A 137
GLU A 141
LEU A 145
 None
 0.49A 4v2oB-5h3hA:
1.1		 4v2oB-5h3hA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hhl RETRON-TYPE REVERSE
TRANSCRIPTASE

([Eubacterium]
rectale) 		PF00078
(RVT_1) 		3 MET A  35
GLU A  39
LEU A  40
 None
 0.80A 4v2oB-5hhlA:
2.0		 4v2oB-5hhlA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs1 LANOSTEROL 14-ALPHA
DEMETHYLASE

(Saccharomyces
cerevisiae) 		PF00067
(p450) 		3 MET A 299
GLU A 303
LEU A 307
 None
 0.39A 4v2oB-5hs1A:
undetectable		 4v2oB-5hs1A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		3 MET A 300
GLU A 304
LEU A 308
 None
 0.48A 4v2oB-5jlcA:
1.1		 4v2oB-5jlcA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k13 RETINOIC ACID
RECEPTOR ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 MET A 321
GLU A 325
LEU A 329
 None
 0.79A 4v2oB-5k13A:
1.2		 4v2oB-5k13A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6q UNCHARACTERIZED
PROTEIN

(Kutzneria
albida) 		PF09017
(Transglut_prok) 		3 MET A  34
GLU A  38
LEU A  42
 None
 0.77A 4v2oB-5m6qA:
undetectable		 4v2oB-5m6qA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mra SORCIN

(Homo sapiens) 		no annotation 3 MET A  90
GLU A  94
LEU A  98
 None
MG  A 202 (-3.9A)
None
 0.78A 4v2oB-5mraA:
undetectable		 4v2oB-5mraA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcp PROTEIN PRGH

(Salmonella
enterica) 		PF09480
(PrgH) 		3 MET 1 267
GLU 1 271
LEU 1 275
 None
 0.54A 4v2oB-5tcp1:
undetectable		 4v2oB-5tcp1:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 3 MET B 314
GLU B 318
LEU B 322
 None
 0.46A 4v2oB-5uanB:
1.1		 4v2oB-5uanB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wft PELB

(Pseudomonas
aeruginosa) 		no annotation 3 MET A 386
GLU A 390
LEU A 394
 None
 0.48A 4v2oB-5wftA:
undetectable		 4v2oB-5wftA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		3 MET A 154
GLU A 158
LEU A 162
 None
 0.63A 4v2oB-5xnsA:
4.8		 4v2oB-5xnsA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 3 MET A 290
GLU A 294
LEU A 298
 None
 0.48A 4v2oB-6ceyA:
undetectable		 4v2oB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1

(Sus scrofa) 		no annotation 3 MET E 151
GLU E 155
LEU E 159
 None
 0.79A 4v2oB-6exvE:
undetectable		 4v2oB-6exvE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1s CGLIIR PROTEIN

(Corynebacterium
glutamicum) 		no annotation 3 MET A 516
GLU A 546
LEU A 552
 None
 0.73A 4v2oB-6f1sA:
undetectable		 4v2oB-6f1sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fx0 RETINOIC ACID
RECEPTOR GAMMA

(Homo sapiens) 		no annotation 3 MET A 323
GLU A 327
LEU A 331
 None
 0.47A 4v2oB-6fx0A:
undetectable		 4v2oB-6fx0A:
undetectable