SIMILAR PATTERNS OF AMINO ACIDS FOR 4V20_A_ACTA1444

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak0 P1 NUCLEASE

(Penicillium
citrinum) 		PF02265
(S1-P1_nuclease) 		4 GLY A 119
THR A 122
HIS A   6
GLY A   5
 None
None
ZN  A 273 (-3.4A)
None
 1.18A 4v20A-1ak0A:
undetectable		 4v20A-1ak0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 GLY A   6
THR A   5
GLY A  63
GLU A   9
 None
 1.04A 4v20A-1brrA:
undetectable		 4v20A-1brrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 GLY A 387
THR A  74
GLY A  70
GLU A  83
 None
None
SF4  A   2 (-3.8A)
None
 1.18A 4v20A-1e08A:
0.0		 4v20A-1e08A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		4 GLY P  28
THR P  26
HIS P  92
GLY P 156
 None
None
ZN  P 304 (-3.3A)
None
 1.11A 4v20A-1e4aP:
0.0		 4v20A-1e4aP:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5m BETA KETOACYL ACYL
CARRIER PROTEIN
SYNTHASE II

(Synechocystis
sp. PCC 6803) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 111
THR A 110
GLY A 114
GLU A 195
 None
 1.16A 4v20A-1e5mA:
0.0		 4v20A-1e5mA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT ALPHA
UREASE SUBUNIT BETA

(Helicobacter
pylori;
Helicobacter
pylori) 		PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY A 171
THR A 172
HIS A 144
GLY B  40
 None
 1.10A 4v20A-1e9yA:
0.0		 4v20A-1e9yA:
18.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 GLY A   4
THR A   5
HIS A  42
GLU A  73
 None
 0.62A 4v20A-1eg1A:
50.4		 4v20A-1eg1A:
42.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2p AMINOPEPTIDASE

(Streptomyces
griseus) 		PF04389
(Peptidase_M28) 		4 GLY A  64
THR A  63
HIS A  29
GLY A  60
 None
 1.04A 4v20A-1f2pA:
0.0		 4v20A-1f2pA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTS, IRON-SULFUR
PROTEIN OF CARBON
MONOXIDE
DEHYDROGENASE
CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava;
Hydrogenophaga
pseudoflava) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 102
THR A 105
HIS A  39
GLY B  33
 FES  A1907 (-4.3A)
None
None
None
 1.16A 4v20A-1ffvA:
0.0		 4v20A-1ffvA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 GLY A 328
THR A 329
GLY A 485
GLU A 358
 BEZ  A1501 (-3.3A)
BEZ  A1501 (-3.9A)
BEZ  A1501 (-3.8A)
MG  A1701 ( 4.3A)
 0.86A 4v20A-1i7qA:
undetectable		 4v20A-1i7qA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 105
THR A 104
GLY A 108
GLU A 189
 None
 1.08A 4v20A-1j3nA:
undetectable		 4v20A-1j3nA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n12 MATURE FIMBRIAL
PROTEIN PAPE

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 GLY A  92
HIS A 121
GLY A  95
GLU A  41
 None
 0.99A 4v20A-1n12A:
undetectable		 4v20A-1n12A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY B 524
THR B 525
HIS B 243
GLY B 556
 None
 1.08A 4v20A-1n60B:
undetectable		 4v20A-1n60B:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE SMALL
CHAIN
CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans;
Oligotropha
carboxidovorans) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 103
THR A 106
HIS A  39
GLY B  36
 FES  A4907 (-4.1A)
None
None
None
 1.13A 4v20A-1n60A:
undetectable		 4v20A-1n60A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o75 47 KDA MEMBRANE
ANTIGEN

(Treponema
pallidum) 		PF14888
(PBP-Tp47_c)
PF14889
(PBP-Tp47_a) 		4 GLY A 289
THR A 288
HIS A 245
GLY A 118
 PDX  A1417 (-3.2A)
None
None
None
 0.93A 4v20A-1o75A:
undetectable		 4v20A-1o75A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLY A  41
THR A 290
GLY A  49
GLU A 286
 None
 1.15A 4v20A-1pieA:
undetectable		 4v20A-1pieA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLY A 128
THR A  60
GLY A  35
GLU A 129
 None
 1.11A 4v20A-1pieA:
undetectable		 4v20A-1pieA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		4 GLY A  83
THR A  85
HIS A  14
GLY A  89
 None
 1.03A 4v20A-1q8fA:
undetectable		 4v20A-1q8fA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s68 RNA LIGASE 2

(Escherichia
virus T4) 		PF09414
(RNA_ligase) 		4 GLY A  38
THR A  39
GLY A 102
GLU A  99
 None
None
None
AMP  A 301 (-3.1A)
 1.17A 4v20A-1s68A:
undetectable		 4v20A-1s68A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT

(Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 246
THR A 249
HIS A 188
GLY A 355
 PCD  A1920 (-3.2A)
PCD  A1920 (-3.8A)
None
None
 1.10A 4v20A-1sb3A:
undetectable		 4v20A-1sb3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542

(Thermus
thermophilus) 		PF02585
(PIG-L) 		4 GLY A  40
THR A  38
GLY A  75
GLU A  41
 None
 1.17A 4v20A-1uanA:
undetectable		 4v20A-1uanA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Enterococcus
faecalis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A1269
THR A1106
GLY A1100
GLU A1105
 None
 1.17A 4v20A-1wueA:
undetectable		 4v20A-1wueA:
18.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		4 GLY A   4
THR A   5
HIS A  42
GLY A  46
 None
 0.73A 4v20A-1z3vA:
65.8		 4v20A-1z3vA:
63.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLY A 393
THR A 446
HIS A 415
GLY A 422
 TPP  A 602 (-3.6A)
None
None
None
 1.01A 4v20A-2ag1A:
undetectable		 4v20A-2ag1A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		4 GLY A 359
THR A 361
HIS A 286
GLY A 317
 None
 1.01A 4v20A-2bkwA:
undetectable		 4v20A-2bkwA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE

(Bacillus
circulans) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 178
THR A 179
GLY A 169
GLU A 162
 None
 0.98A 4v20A-2c81A:
undetectable		 4v20A-2c81A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 579
THR A 580
GLY A 576
GLU A 582
 None
 0.90A 4v20A-2ecfA:
undetectable		 4v20A-2ecfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqf HYPOTHETICAL PROTEIN
HI0933

(Haemophilus
influenzae) 		PF03486
(HI0933_like) 		4 GLY A 166
THR A 344
GLY A 347
GLU A 371
 None
None
None
FAD  A 403 (-4.1A)
 1.08A 4v20A-2gqfA:
undetectable		 4v20A-2gqfA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION

(Escherichia
virus T4) 		PF09414
(RNA_ligase) 		4 GLY A  38
THR A  39
GLY A 102
GLU A  99
 None
None
None
APK  A  35 ( 3.3A)
 1.17A 4v20A-2hvqA:
undetectable		 4v20A-2hvqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i2x METHYLTRANSFERASE 1

(Methanosarcina
barkeri) 		PF12176
(MtaB) 		4 GLY A 270
THR A 218
GLY A 266
GLU A 272
 None
ZN  A 501 ( 4.7A)
None
None
 0.96A 4v20A-2i2xA:
undetectable		 4v20A-2i2xA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4y RUBREDOXIN

(Mycobacterium
ulcerans) 		PF00301
(Rubredoxin) 		4 GLY A  27
THR A  28
GLY A  18
GLU A  15
 None
 1.16A 4v20A-2m4yA:
undetectable		 4v20A-2m4yA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Aquifex
aeolicus) 		PF00793
(DAHP_synth_1) 		4 GLY A1155
THR A1156
GLY A1126
GLU A1153
 None
 1.15A 4v20A-2nxgA:
undetectable		 4v20A-2nxgA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5n MUHV1GPM153

(Murid
betaherpesvirus
1) 		PF11624
(M157) 		4 GLY A  35
THR A  34
GLY A  53
GLU A  36
 None
 1.12A 4v20A-2o5nA:
undetectable		 4v20A-2o5nA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 GLY A 272
THR A 273
GLY A   8
GLU A 267
 None
None
ACY  A 500 ( 4.7A)
None
 0.72A 4v20A-2qc3A:
undetectable		 4v20A-2qc3A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qma DIAMINOBUTYRATE-PYRU
VATE TRANSAMINASE
AND
L-2,4-DIAMINOBUTYRAT
E DECARBOXYLASE

(Vibrio
parahaemolyticus) 		PF00282
(Pyridoxal_deC) 		4 GLY A 795
THR A 625
HIS A 785
GLY A 628
 None
 1.17A 4v20A-2qmaA:
undetectable		 4v20A-2qmaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		4 GLY A 111
THR A 110
HIS A 116
GLY A 122
 None
 0.92A 4v20A-2qvpA:
undetectable		 4v20A-2qvpA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrk ALPHA-L-ARABINOFURAN
OSIDASE

(Thermobacillus
xylanilyticus) 		PF06964
(Alpha-L-AF_C) 		4 GLY A 109
THR A 110
GLY A  86
GLU A 112
 None
 1.16A 4v20A-2vrkA:
undetectable		 4v20A-2vrkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxb COENZYME
B12-DEPENDENT MUTASE

(Aeropyrum
pernix) 		PF02310
(B12-binding) 		4 GLY A 109
THR A 110
HIS A  84
GLY A  82
 None
 1.20A 4v20A-2yxbA:
undetectable		 4v20A-2yxbA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zki 199AA LONG
HYPOTHETICAL TRP
REPRESSOR BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF03358
(FMN_red) 		4 GLY A 157
THR A 156
HIS A 123
GLY A 167
 None
 0.82A 4v20A-2zkiA:
undetectable		 4v20A-2zkiA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE

(Pseudomonas
putida) 		PF00202
(Aminotran_3) 		4 GLY X 151
HIS X 153
GLY X 147
GLU X 226
 None
None
None
PLP  X 450 (-4.0A)
 1.12A 4v20A-3a8uX:
undetectable		 4v20A-3a8uX:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 GLY A 257
THR A 256
GLY A 237
GLU A 240
 None
None
None
CA  A1001 (-2.3A)
 0.84A 4v20A-3a9gA:
undetectable		 4v20A-3a9gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 GLY A 257
THR A 256
GLY A 272
GLU A 240
 None
None
None
CA  A1001 (-2.3A)
 0.88A 4v20A-3a9gA:
undetectable		 4v20A-3a9gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		4 GLY A  47
THR A  48
GLY A  43
GLU A  50
 None
 0.97A 4v20A-3a9lA:
undetectable		 4v20A-3a9lA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 GLY A 178
THR A 180
HIS A 176
GLY A 220
 None
None
PLP  A 401 ( 3.6A)
None
 1.15A 4v20A-3anvA:
undetectable		 4v20A-3anvA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2y METALLOPEPTIDASE
CONTAINING
CO-CATALYTIC
METALLOACTIVE SITE

(Shewanella
denitrificans) 		PF04952
(AstE_AspA) 		4 GLY A 112
THR A 111
HIS A 117
GLY A 123
 None
 0.93A 4v20A-3b2yA:
undetectable		 4v20A-3b2yA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bac DNA LIGASE

(Haemophilus
influenzae) 		PF01653
(DNA_ligase_aden) 		4 GLY A 143
THR A 136
HIS A  75
GLY A 140
 None
 1.16A 4v20A-3bacA:
undetectable		 4v20A-3bacA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bry TBUX

(Ralstonia
pickettii) 		PF03349
(Toluene_X) 		4 GLY A  20
THR A  19
GLY A 284
GLU A  32
 None
 1.09A 4v20A-3bryA:
undetectable		 4v20A-3bryA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i44 ALDEHYDE
DEHYDROGENASE

(Bartonella
henselae) 		PF00171
(Aldedh) 		4 GLY A 318
THR A 317
HIS A 320
GLY A 314
 None
 1.12A 4v20A-3i44A:
undetectable		 4v20A-3i44A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieh PUTATIVE
METALLOPEPTIDASE

(Shewanella
baltica) 		PF04952
(AstE_AspA) 		4 GLY A 112
THR A 111
HIS A 117
GLY A 123
 None
 0.97A 4v20A-3iehA:
undetectable		 4v20A-3iehA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muo PROLYL ENDOPEPTIDASE

(Aeromonas
caviae) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLY A 213
THR A 214
GLY A 184
GLU A 166
 None
 0.94A 4v20A-3muoA:
undetectable		 4v20A-3muoA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr1 HD DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13328
(HD_4) 		4 GLY A 159
THR A 160
GLY A 156
GLU A 165
 None
 1.10A 4v20A-3nr1A:
undetectable		 4v20A-3nr1A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oky PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI) 		4 GLY A  86
THR A  85
GLY A 130
GLU A  88
 None
 1.16A 4v20A-3okyA:
undetectable		 4v20A-3okyA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oth CALG1

(Micromonospora
echinospora) 		PF00201
(UDPGT)
PF03033
(Glyco_transf_28) 		4 GLY A 230
THR A 231
HIS A 295
GLY A 299
 TYD  A 393 ( 3.7A)
TYD  A 393 (-3.1A)
TYD  A 393 (-3.9A)
TYD  A 393 (-3.6A)
 1.03A 4v20A-3othA:
undetectable		 4v20A-3othA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		4 GLY A  58
THR A  61
HIS A  87
GLY A  85
 None
 1.09A 4v20A-3ou6A:
undetectable		 4v20A-3ou6A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouk PROBABLE CONSERVED
TRANSMEMBRANE
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A 202
HIS A 152
GLY A  36
GLU A 200
 None
 0.88A 4v20A-3oukA:
undetectable		 4v20A-3oukA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		4 GLY A  23
THR A  24
HIS A  67
GLY A  68
 None
 1.08A 4v20A-3ozbA:
undetectable		 4v20A-3ozbA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q94 FRUCTOSE-BISPHOSPHAT
E ALDOLASE, CLASS II

(Bacillus
anthracis) 		PF01116
(F_bP_aldolase) 		4 GLY A 139
THR A 140
GLY A 178
GLU A 137
 None
 1.05A 4v20A-3q94A:
undetectable		 4v20A-3q94A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpb URIDINE
PHOSPHORYLASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		4 GLY A 121
THR A 122
GLY A  73
GLU A 120
 None
 1.16A 4v20A-3qpbA:
undetectable		 4v20A-3qpbA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2u UDP-N-ACETYLGLUCOSAM
INE--N-ACETYLMURAMYL
-(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Pseudomonas
aeruginosa) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 GLY A  37
THR A  38
GLY A 101
GLU A  43
 None
 0.94A 4v20A-3s2uA:
undetectable		 4v20A-3s2uA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 GLY A 285
THR A 286
GLY A 214
GLU A 277
 None
 0.99A 4v20A-3s6hA:
undetectable		 4v20A-3s6hA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		4 GLY A 163
THR A 341
GLY A 344
GLU A 368
 None
None
None
FDA  A 547 (-4.1A)
 1.18A 4v20A-3v76A:
undetectable		 4v20A-3v76A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 GLY A 195
THR A 196
HIS A 303
GLY A 198
 None
 1.03A 4v20A-3wdjA:
undetectable		 4v20A-3wdjA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrf NON-REDUCING END
BETA-L-ARABINOFURANO
SIDASE

(Bifidobacterium
longum) 		PF07944
(Glyco_hydro_127) 		4 GLY A 313
THR A 312
GLY A 337
GLU A 368
 None
 1.17A 4v20A-3wrfA:
undetectable		 4v20A-3wrfA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a69 HISTONE DEACETYLASE
3,

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		4 GLY A 204
THR A 203
GLY A 174
GLU A 208
 None
 0.97A 4v20A-4a69A:
undetectable		 4v20A-4a69A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez WD REPEAT-CONTAINING
PROTEIN SLP1
MITOTIC SPINDLE
CHECKPOINT COMPONENT
MAD3

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40)
PF08311
(Mad3_BUB1_I) 		4 GLY A 367
THR A 368
GLY A 410
GLU C  21
 None
 1.09A 4v20A-4aezA:
undetectable		 4v20A-4aezA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b16 CHITINASE LIKE
LECTIN

(Tamarindus
indica) 		PF00704
(Glyco_hydro_18) 		4 GLY A  17
HIS A  59
GLY A  57
GLU A  23
 None
 0.94A 4v20A-4b16A:
undetectable		 4v20A-4b16A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b98 BETA-ALANINE--PYRUVA
TE TRANSAMINASE

(Pseudomonas
aeruginosa) 		PF00202
(Aminotran_3) 		4 GLY A 152
HIS A 154
GLY A 148
GLU A 226
 None
None
None
PXG  A 470 (-3.9A)
 1.11A 4v20A-4b98A:
undetectable		 4v20A-4b98A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1
APC/C-CDH1 MODULATOR
1

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40)
no annotation 		4 GLY A 448
THR A 449
GLY A 491
GLU I  99
 None
 1.12A 4v20A-4bh6A:
undetectable		 4v20A-4bh6A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE

(Mycobacterium
tuberculosis) 		PF02585
(PIG-L) 		4 GLY A  43
THR A  41
GLY A  97
GLU A  44
 GOL  A 405 (-3.5A)
None
GOL  A 405 (-3.6A)
None
 0.93A 4v20A-4ewlA:
undetectable		 4v20A-4ewlA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		4 GLY A 101
THR A 143
HIS A 105
GLY A 147
 None
 1.12A 4v20A-4fr2A:
undetectable		 4v20A-4fr2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9i HYDROGENASE
MATURATION PROTEIN
HYPF

(Thermococcus
kodakarensis) 		PF00708
(Acylphosphatase)
PF00814
(Peptidase_M22)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 GLY A 522
HIS A 487
GLY A 510
GLU A 523
 None
 1.01A 4v20A-4g9iA:
undetectable		 4v20A-4g9iA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lba CONJUGATIVE
TRANSPOSON
LIPOPROTEIN

(Bacteroides
eggerthii) 		PF12988
(DUF3872) 		4 GLY A 120
HIS A 124
GLY A  89
GLU A 122
 None
 1.19A 4v20A-4lbaA:
undetectable		 4v20A-4lbaA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn8 LRR RECEPTOR-LIKE
SERINE/THREONINE-PRO
TEIN KINASE FLS2
FLG22

(Arabidopsis
thaliana;
) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8)
PF00669
(Flagellin_N) 		4 GLY A 368
THR A 366
HIS A 392
GLY C  82
 None
None
None
SO4  C 101 (-3.3A)
 1.03A 4v20A-4mn8A:
undetectable		 4v20A-4mn8A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6d CONSERVED
HYPOTHETICAL
PERIPLASMIC PROTEIN

(Zobellia
galactanivorans) 		no annotation 4 GLY A  83
THR A  84
HIS A 365
GLY A  80
 None
None
None
EDO  A 514 (-4.0A)
 1.19A 4v20A-4u6dA:
undetectable		 4v20A-4u6dA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhm OMEGA AMINO
ACID-PYRUVATE
AMINOTRANSFERASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		4 GLY A 152
HIS A 154
GLY A 148
GLU A 226
 None
None
None
PLP  A1458 (-4.0A)
 1.08A 4v20A-4uhmA:
undetectable		 4v20A-4uhmA:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		5 GLY A   4
THR A   5
HIS A  42
GLY A  45
GLU A  74
 ACT  A1444 ( 3.7A)
ACT  A1444 (-3.9A)
ACT  A1444 (-4.6A)
ACT  A1444 (-3.8A)
ACT  A1444 ( 4.8A)
 0.00A 4v20A-4v20A:
75.5		 4v20A-4v20A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLY A 438
THR A 439
HIS A 189
GLY A 470
 None
 1.04A 4v20A-4zohA:
undetectable		 4v20A-4zohA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3k PUTATIVE
PTERIDINE-DEPENDENT
DIOXYGENASE

(Streptomyces
hygroscopicus) 		no annotation 4 GLY A 240
THR A 241
GLY A 337
GLU A 334
 3HB  A1341 ( 4.2A)
None
None
None
 0.73A 4v20A-5a3kA:
undetectable		 4v20A-5a3kA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		4 GLY A   4
THR A   5
HIS A  42
GLY A  46
 None
 0.81A 4v20A-5ampA:
68.0		 4v20A-5ampA:
71.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX

(Streptomyces
atroolivaceus) 		PF02585
(PIG-L) 		4 GLY A  51
THR A  49
GLY A  92
GLU A  52
 ACT  A 301 (-3.8A)
None
ACT  A 301 ( 4.8A)
None
 1.08A 4v20A-5bmoA:
undetectable		 4v20A-5bmoA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm5 MYOMESIN-1
OBSCURIN-LIKE-1

(Homo sapiens;
Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 GLY M 552
THR M 553
HIS O 280
GLY O 283
 None
 0.93A 4v20A-5fm5M:
undetectable		 4v20A-5fm5M:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		4 GLY C 226
THR C 228
HIS C 201
GLY C 202
 None
None
KCX  C 220 ( 4.6A)
None
 1.09A 4v20A-5fseC:
undetectable		 4v20A-5fseC:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		4 GLY B 333
THR B 332
GLY B 314
GLU B 326
 NA  B4001 ( 4.3A)
None
None
NA  B4001 (-2.6A)
 1.13A 4v20A-5gztB:
undetectable		 4v20A-5gztB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvf CARBOXYPEPTIDASE B2
VHH-I83

(Homo sapiens;
Vicugna pacos) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
PF07686
(V-set) 		4 GLY A 368
THR A 367
HIS A  47
GLY B  98
 None
 0.96A 4v20A-5hvfA:
undetectable		 4v20A-5hvfA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 GLY A  32
THR A  31
GLY A 117
GLU A 809
 None
 1.14A 4v20A-5jxlA:
undetectable		 4v20A-5jxlA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 GLY A 257
THR A 258
GLY A 407
GLU A 281
 ACT  A 503 (-3.2A)
ACT  A 503 (-3.7A)
ACT  A 503 (-3.8A)
FE2  A 501 ( 4.1A)
 0.79A 4v20A-5jy9A:
undetectable		 4v20A-5jy9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8b 8-AMINO-3,8-DIDEOXY-
ALPHA-D-MANNO-OCTULO
SONATE TRANSAMINASE

(Shewanella
oneidensis) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 172
THR A 173
GLY A 164
GLU A 156
 None
 0.84A 4v20A-5k8bA:
undetectable		 4v20A-5k8bA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m89 SPLICEOSOME WD40 SC

(Chaetomium
thermophilum) 		no annotation 4 GLY A 252
THR A 251
GLY A 292
GLU A 212
 None
 1.13A 4v20A-5m89A:
undetectable		 4v20A-5m89A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		4 GLY A  23
THR A  24
HIS A  61
GLY A  65
 None
 0.58A 4v20A-5mchA:
63.7		 4v20A-5mchA:
56.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5c PUTATIVE
DECARBOXYLASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 4 GLY A 337
THR A 165
HIS A 327
GLY A 168
 None
None
PLP  A 601 (-4.0A)
PLP  A 601 (-3.2A)
 1.19A 4v20A-5o5cA:
undetectable		 4v20A-5o5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		4 GLY A 170
THR A 171
HIS A 130
GLU A 154
 None
 0.91A 4v20A-5uidA:
undetectable		 4v20A-5uidA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj1 MDCA

(Pseudomonas
aeruginosa) 		PF16957
(Mal_decarbox_Al) 		4 GLY A 313
THR A 314
GLY A 166
GLU A 170
 None
 1.05A 4v20A-5vj1A:
undetectable		 4v20A-5vj1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 GLY A   4
THR A   5
HIS A  42
GLU A  73
 GLY  A   4 ( 0.0A)
THR  A   5 ( 0.8A)
HIS  A  42 ( 1.0A)
GLU  A  73 ( 0.6A)
 0.44A 4v20A-5w0aA:
50.4		 4v20A-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 4 GLY A  82
THR A  83
GLY A  50
GLU A  48
 None
 0.91A 4v20A-5wslA:
undetectable		 4v20A-5wslA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 GLY A 582
THR A 583
GLY A 579
GLU A 585
 None
 1.01A 4v20A-5yp3A:
undetectable		 4v20A-5yp3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6egx STRUCTURAL PROTEIN
VP1

(Sacbrood virus) 		no annotation 4 GLY A 192
THR A 194
HIS A 122
GLY A 197
 None
 1.08A 4v20A-6egxA:
undetectable		 4v20A-6egxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 GLY A  13
THR A  12
HIS A 356
GLY A 354
 None
 0.98A 4v20A-6en4A:
undetectable		 4v20A-6en4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 GLY A 281
THR A 282
HIS A 367
GLY A 377
 None
BJ8  A 501 (-3.9A)
None
None
 0.99A 4v20A-6enoA:
undetectable		 4v20A-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f1j -

(-) 		no annotation 4 GLY A 179
THR A 207
HIS A 180
GLY A 153
 None
None
ZN  A 406 (-3.3A)
None
 1.12A 4v20A-6f1jA:
undetectable		 4v20A-6f1jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 4 GLY A 942
THR A 943
GLY A1007
GLU A  28
 None
 0.72A 4v20A-6fuyA:
undetectable		 4v20A-6fuyA:
undetectable