SIMILAR PATTERNS OF AMINO ACIDS FOR 4V1F_C_BQ1C1087_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1att ANTITHROMBIN III

(Bos taurus)
PF00079
(Serpin)
3 GLU A 382
ALA A 383
PHE A 373
None
0.67A 4v1fC-1attA:
undetectable
4v1fC-1attA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica)
PF00161
(RIP)
3 GLU Y  90
ALA Y  91
PHE Y  94
None
0.60A 4v1fC-1bryY:
undetectable
4v1fC-1bryY:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT


(Shigella
dysenteriae)
PF00161
(RIP)
3 GLU A 167
ALA A 168
PHE A 171
None
0.56A 4v1fC-1dm0A:
0.0
4v1fC-1dm0A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezi CMP-N-ACETYLNEURAMIN
IC ACID SYNTHETASE


(Neisseria
meningitidis)
PF02348
(CTP_transf_3)
3 GLU A  60
ALA A  61
PHE A  64
None
0.58A 4v1fC-1eziA:
undetectable
4v1fC-1eziA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)


(Trichosanthes
kirilowii)
PF00161
(RIP)
3 GLU A 164
ALA A 165
PHE A 168
None
0.63A 4v1fC-1ggpA:
undetectable
4v1fC-1ggpA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kjv MATURE ALPHA CHAIN
OF MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
ANTIGEN (HEAVY
CHAIN)


(Rattus
norvegicus)
PF00129
(MHC_I)
PF07654
(C1-set)
3 GLU A 114
ALA A 125
PHE A 116
None
0.66A 4v1fC-1kjvA:
0.7
4v1fC-1kjvA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lln ANTIVIRAL PROTEIN 3

(Phytolacca
americana)
PF00161
(RIP)
3 GLU A 172
ALA A 173
PHE A 176
None
0.50A 4v1fC-1llnA:
0.2
4v1fC-1llnA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE


(Lactococcus
lactis)
PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N)
3 GLU A 746
ALA A 568
PHE A 567
None
0.66A 4v1fC-1lnsA:
undetectable
4v1fC-1lnsA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus)
PF00161
(RIP)
3 GLU A 177
ALA A 178
PHE A 181
CMP  A 901 (-3.9A)
None
None
0.49A 4v1fC-1lpcA:
0.0
4v1fC-1lpcA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 GLU A 302
ALA A 303
PHE A 306
None
0.63A 4v1fC-1o8cA:
undetectable
4v1fC-1o8cA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
americana)
PF00161
(RIP)
3 GLU A 176
ALA A 177
PHE A 180
APT  A 901 ( 3.6A)
None
None
0.62A 4v1fC-1qcjA:
undetectable
4v1fC-1qcjA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT


(Escherichia
coli)
PF00161
(RIP)
3 GLU A 167
ALA A 168
PHE A 171
None
0.58A 4v1fC-1r4pA:
undetectable
4v1fC-1r4pA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw2 ATP-DEPENDENT DNA
HELICASE II, 80 KDA
SUBUNIT


(Homo sapiens)
PF08785
(Ku_PK_bind)
3 GLU A  87
ALA A  88
PHE A  91
None
0.37A 4v1fC-1rw2A:
undetectable
4v1fC-1rw2A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa)
PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel)
3 GLU A 307
ALA A 306
PHE A 252
None
0.62A 4v1fC-1sy7A:
undetectable
4v1fC-1sy7A:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uai POLYGULURONATE LYASE

(Corynebacterium
sp.)
PF08787
(Alginate_lyase2)
3 GLU A 101
ALA A 102
PHE A 103
None
0.64A 4v1fC-1uaiA:
undetectable
4v1fC-1uaiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukr ENDO-1,4-B-XYLANASE
I


(Aspergillus
niger)
PF00457
(Glyco_hydro_11)
3 GLU A  79
ALA A  78
PHE A 127
None
0.63A 4v1fC-1ukrA:
undetectable
4v1fC-1ukrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y13 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE


(Plasmodium
falciparum)
PF01242
(PTPS)
3 GLU A  38
ALA A  32
PHE A  36
BIO  A 175 (-2.6A)
None
None
0.67A 4v1fC-1y13A:
undetectable
4v1fC-1y13A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0s 6-PYRUVOYL
TETRAHYDROPTERIN
SYNTHASE


(Plasmodium
vivax)
PF01242
(PTPS)
3 GLU A  45
ALA A  39
PHE A  43
BIO  A 282 (-3.1A)
None
None
0.58A 4v1fC-2a0sA:
undetectable
4v1fC-2a0sA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ap1 PUTATIVE REGULATOR
PROTEIN


(Salmonella
enterica)
PF00480
(ROK)
3 GLU A 113
ALA A 114
PHE A 119
None
0.50A 4v1fC-2ap1A:
undetectable
4v1fC-2ap1A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi7 UDP-GALACTOPYRANOSE
MUTASE


(Klebsiella
pneumoniae)
PF03275
(GLF)
PF13450
(NAD_binding_8)
3 GLU A 138
ALA A 139
PHE A 142
None
0.67A 4v1fC-2bi7A:
undetectable
4v1fC-2bi7A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE


(Paenarthrobacter
nicotinovorans)
PF01565
(FAD_binding_4)
PF08031
(BBE)
3 GLU A 117
ALA A 118
PHE A 121
None
0.59A 4v1fC-2bvgA:
undetectable
4v1fC-2bvgA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA


(Drosophila
melanogaster)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLU A 337
ALA A 338
PHE A 341
ANP  A2901 ( 4.6A)
None
None
0.40A 4v1fC-2db3A:
undetectable
4v1fC-2db3A:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN


(Silene
chalcedonica)
PF00161
(RIP)
3 GLU A 170
ALA A 171
PHE A 174
None
0.58A 4v1fC-2g5xA:
undetectable
4v1fC-2g5xA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN


(Clostridium
acetobutylicum)
PF01979
(Amidohydro_1)
3 GLU A 101
ALA A 103
PHE A 105
None
0.66A 4v1fC-2i9uA:
undetectable
4v1fC-2i9uA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jex REGULATORY PROTEIN
E2


(Deltapapillomavirus
4)
PF00508
(PPV_E2_N)
3 GLU A 176
ALA A 177
PHE A 180
None
0.46A 4v1fC-2jexA:
2.8
4v1fC-2jexA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjw UNCHARACTERIZED
PROTEIN YHL002W


(Saccharomyces
cerevisiae)
no annotation 3 GLU H 289
ALA H 290
PHE H 293
None
0.65A 4v1fC-2pjwH:
3.4
4v1fC-2pjwH:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8w POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
acinosa)
PF00161
(RIP)
3 GLU A 175
ALA A 176
PHE A 179
None
0.64A 4v1fC-2q8wA:
undetectable
4v1fC-2q8wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qes RIBOSOME-INACTIVATIN
G PROTEIN PD-L4


(Phytolacca
dioica)
PF00161
(RIP)
3 GLU A 175
ALA A 176
PHE A 179
ADE  A 501 ( 4.7A)
None
None
0.60A 4v1fC-2qesA:
undetectable
4v1fC-2qesA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA


(Escherichia
coli)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
3 GLU A 218
ALA A 219
PHE A 377
None
0.48A 4v1fC-2vdaA:
3.5
4v1fC-2vdaA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vko TM1634

(Thermotoga
maritima)
no annotation 3 GLU A  94
ALA A  95
PHE A  98
None
0.64A 4v1fC-2vkoA:
undetectable
4v1fC-2vkoA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III


(Cinnamomum
camphora)
PF00161
(RIP)
PF00652
(Ricin_B_lectin)
3 GLU A 167
ALA A 168
PHE A 171
None
0.66A 4v1fC-2vlcA:
undetectable
4v1fC-2vlcA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zr1 AGGLUTININ-1 CHAIN A

(Abrus
precatorius)
PF00161
(RIP)
3 GLU A 163
ALA A 164
PHE A 167
None
0.59A 4v1fC-2zr1A:
undetectable
4v1fC-2zr1A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aex THREONINE SYNTHASE

(Thermus
thermophilus)
PF00291
(PALP)
3 GLU A 264
ALA A 265
PHE A 217
None
0.60A 4v1fC-3aexA:
undetectable
4v1fC-3aexA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cma 50S RIBOSOMAL
PROTEIN L32E


(Haloarcula
marismortui)
PF01655
(Ribosomal_L32e)
3 GLU Y 165
ALA Y 166
PHE Y 168
G  01089 ( 3.7A)
G  01269 ( 3.3A)
A  01090 ( 3.7A)
0.63A 4v1fC-3cmaY:
undetectable
4v1fC-3cmaY:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctk RRNA N-GLYCOSIDASE

(Bougainvillea
spectabilis)
PF00161
(RIP)
3 GLU A 165
ALA A 166
PHE A 169
None
0.58A 4v1fC-3ctkA:
undetectable
4v1fC-3ctkA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dah RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE


(Burkholderia
pseudomallei)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
3 GLU A 270
ALA A 248
PHE A 247
None
0.66A 4v1fC-3dahA:
undetectable
4v1fC-3dahA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II


(Bartonella
henselae)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 GLU A 264
ALA A 263
PHE A 418
None
0.63A 4v1fC-3e60A:
undetectable
4v1fC-3e60A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5k RIBOSOME-INACTIVATIN
G PROTEIN
PD-L1/PD-L2


(Phytolacca
dioica)
PF00161
(RIP)
3 GLU A 175
ALA A 176
PHE A 179
None
0.60A 4v1fC-3h5kA:
undetectable
4v1fC-3h5kA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis)
PF00161
(RIP)
3 GLU A 174
ALA A 175
PHE A 178
None
0.60A 4v1fC-3hiqA:
undetectable
4v1fC-3hiqA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis)
PF00161
(RIP)
3 GLU A 174
ALA A 175
PHE A 178
C2X  A 260 (-3.0A)
None
None
0.59A 4v1fC-3hiwA:
undetectable
4v1fC-3hiwA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE


(Bacillus
subtilis)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 GLU A 415
ALA A 416
PHE A 419
None
0.52A 4v1fC-3k8zA:
undetectable
4v1fC-3k8zA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ku0 RIBOSOME-INACTIVATIN
G PROTEIN GELONIN


(Suregada
multiflora)
PF00161
(RIP)
3 GLU A 166
ALA A 167
PHE A 170
ADE  A 800 ( 4.5A)
None
None
0.62A 4v1fC-3ku0A:
undetectable
4v1fC-3ku0A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4f ENDO-1,4-BETA-XYLANA
SE


(Acidomyces
acidophilus)
PF00457
(Glyco_hydro_11)
3 GLU A 102
ALA A 101
PHE A 150
None
0.66A 4v1fC-3m4fA:
undetectable
4v1fC-3m4fA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7b RIBOSOME BIOGENESIS
NEP1 RNA
METHYLTRANSFERASE


(Archaeoglobus
fulgidus)
PF03587
(EMG1)
3 GLU A   9
ALA A  10
PHE A 171
None
None
SAH  A 301 (-4.3A)
0.65A 4v1fC-3o7bA:
undetectable
4v1fC-3o7bA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN


(Lutzomyia
longipalpis)
PF03022
(MRJP)
3 GLU A  57
ALA A  56
PHE A  41
None
0.62A 4v1fC-3q6tA:
undetectable
4v1fC-3q6tA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
3 GLU X  97
ALA X  98
PHE X  99
None
None
FRU  X 801 (-4.0A)
0.56A 4v1fC-3rwkX:
undetectable
4v1fC-3rwkX:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE


(Toxoplasma
gondii)
PF00342
(PGI)
3 GLU A 409
ALA A 342
PHE A 384
None
0.63A 4v1fC-3ujhA:
undetectable
4v1fC-3ujhA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w2z METHYL-ACCEPTING
CHEMOTAXIS PROTEIN


(Nostoc sp. PCC
7120)
PF01590
(GAF)
3 GLU A 144
ALA A 143
PHE A 141
None
0.67A 4v1fC-3w2zA:
undetectable
4v1fC-3w2zA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdq BETA-MANNANASE

(Symbiotic
protist of
Reticulitermes
speratus)
PF02156
(Glyco_hydro_26)
3 GLU A 191
ALA A 192
PHE A 197
None
0.50A 4v1fC-3wdqA:
undetectable
4v1fC-3wdqA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wiw GLYCOSYL HYDROLASE
FAMILY 88


(Pedobacter
heparinus)
PF07470
(Glyco_hydro_88)
3 GLU A  97
ALA A  98
PHE A 101
None
0.22A 4v1fC-3wiwA:
undetectable
4v1fC-3wiwA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wt0 CELL DIVISION
PROTEIN FTSA


(Staphylococcus
aureus)
PF02491
(SHS2_FTSA)
PF14450
(FtsA)
3 GLU A 294
ALA A 260
PHE A 261
None
0.67A 4v1fC-3wt0A:
undetectable
4v1fC-3wt0A:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zm8 GH26
ENDO-BETA-1,4-MANNAN
ASE


(Podospora
anserina)
PF02156
(Glyco_hydro_26)
PF16990
(CBM_35)
3 GLU A 300
ALA A 301
PHE A 306
TLA  A1452 (-2.8A)
None
None
0.52A 4v1fC-3zm8A:
undetectable
4v1fC-3zm8A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cng SPOU RRNA METHYLASE

(Sulfolobus
acidocaldarius)
PF00588
(SpoU_methylase)
3 GLU A  42
ALA A  43
PHE A  46
None
0.63A 4v1fC-4cngA:
undetectable
4v1fC-4cngA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d25 BMVLG PROTEIN

(Bombyx mori)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLU A 276
ALA A 277
PHE A 280
ANP  A1564 ( 4.5A)
None
None
0.28A 4v1fC-4d25A:
undetectable
4v1fC-4d25A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
3 GLU A  77
ALA A  78
PHE A  81
None
0.66A 4v1fC-4dalA:
undetectable
4v1fC-4dalA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejy 3-METHYLADENINE DNA
GLYCOSYLASE


(Caldanaerobacter
subterraneus)
PF00730
(HhH-GPD)
PF07934
(OGG_N)
3 GLU A  99
ALA A 100
PHE A 103
None
0.51A 4v1fC-4ejyA:
undetectable
4v1fC-4ejyA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4z DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus)
no annotation 3 GLU B  49
ALA B  50
PHE B  53
None
0.64A 4v1fC-4f4zB:
undetectable
4v1fC-4f4zB:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbh PROTEIN SYNTHESIS
INHIBITOR I


(Hordeum vulgare)
PF00161
(RIP)
3 GLU A 175
ALA A 176
PHE A 179
AMP  A 301 ( 4.8A)
None
None
0.54A 4v1fC-4fbhA:
undetectable
4v1fC-4fbhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvl MEMBRANE-ANCHORED
MYCOSIN MYCP1


(Mycolicibacterium
thermoresistibile)
PF00082
(Peptidase_S8)
3 GLU A  76
ALA A  77
PHE A  80
None
0.64A 4v1fC-4hvlA:
undetectable
4v1fC-4hvlA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Pseudomonas
aeruginosa)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
3 GLU A 257
ALA A 256
PHE A 412
None
0.61A 4v1fC-4jb6A:
undetectable
4v1fC-4jb6A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ln9 RIFAMYCIN POLYKETIDE
SYNTHASE


(Amycolatopsis
mediterranei)
PF14765
(PS-DH)
3 GLU A 208
ALA A 209
PHE A 212
None
0.65A 4v1fC-4ln9A:
undetectable
4v1fC-4ln9A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Campylobacter
jejuni)
PF00478
(IMPDH)
3 GLU A 323
ALA A 324
PHE A 327
None
0.62A 4v1fC-4mz1A:
undetectable
4v1fC-4mz1A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1


(Schizosaccharomyces
pombe)
no annotation 3 GLU B 444
ALA B 445
PHE B 446
None
0.63A 4v1fC-4o9dB:
undetectable
4v1fC-4o9dB:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oky RESTRICTION
ENDONUCLEASE PVURTS1
I


(Proteus
vulgaris)
no annotation 3 GLU C 239
ALA C 266
PHE C 279
None
0.66A 4v1fC-4okyC:
undetectable
4v1fC-4okyC:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4px9 ATP-DEPENDENT RNA
HELICASE DDX3X


(Homo sapiens)
PF00270
(DEAD)
3 GLU A 285
ALA A 286
PHE A 289
ADP  A 601 ( 4.4A)
None
None
0.63A 4v1fC-4px9A:
undetectable
4v1fC-4px9A:
15.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4v1g F0F1 ATP SYNTHASE
SUBUNIT C


(Mycolicibacterium
phlei)
PF00137
(ATP-synt_C)
3 GLU A  65
ALA A  66
PHE A  69
None
0.01A 4v1fC-4v1gA:
14.1
4v1fC-4v1gA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydw DARPIN 44C12V5

(synthetic
construct)
PF12796
(Ank_2)
PF13637
(Ank_4)
3 GLU A  56
ALA A  87
PHE A  89
None
0.52A 4v1fC-4ydwA:
undetectable
4v1fC-4ydwA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzz TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN


(Bordetella
bronchiseptica)
PF03480
(DctP)
3 GLU A 343
ALA A 344
PHE A 347
None
0.25A 4v1fC-4yzzA:
undetectable
4v1fC-4yzzA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a15 BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD16


(Homo sapiens)
PF02214
(BTB_2)
3 GLU A 109
ALA A 110
PHE A 113
None
0.37A 4v1fC-5a15A:
undetectable
4v1fC-5a15A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxd BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD1


(Homo sapiens)
PF02214
(BTB_2)
3 GLU A 111
ALA A 112
PHE A 115
None
0.38A 4v1fC-5bxdA:
undetectable
4v1fC-5bxdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxh BTB/POZ
DOMAIN-CONTAINING
PROTEIN KCTD9


(Homo sapiens)
PF02214
(BTB_2)
3 GLU A  86
ALA A  87
PHE A  90
None
0.29A 4v1fC-5bxhA:
undetectable
4v1fC-5bxhA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c05 PUTATIVE
GAMMA-TERPINENE
SYNTHASE


(Thymus vulgaris)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
3 GLU A 255
ALA A 256
PHE A 259
GLU  A 255 ( 0.5A)
ALA  A 256 ( 0.0A)
PHE  A 259 (-1.3A)
0.58A 4v1fC-5c05A:
undetectable
4v1fC-5c05A:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjj PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE


(Campylobacter
jejuni)
PF00551
(Formyl_trans_N)
3 GLU A  17
ALA A  51
PHE A  54
None
0.50A 4v1fC-5cjjA:
undetectable
4v1fC-5cjjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da0 SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
PF01740
(STAS)
3 GLU A  38
ALA A  39
PHE A  42
None
0.47A 4v1fC-5da0A:
undetectable
4v1fC-5da0A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddz RICIN

(Ricinus
communis)
PF00161
(RIP)
3 GLU A 177
ALA A 178
PHE A 181
None
0.49A 4v1fC-5ddzA:
undetectable
4v1fC-5ddzA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B


(Homo sapiens)
PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12)
3 GLU A 450
ALA A 451
PHE A 454
None
0.59A 4v1fC-5dseA:
undetectable
4v1fC-5dseA:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLU A 371
ALA A 372
PHE A 375
ADP  A 801 ( 3.7A)
None
None
0.49A 4v1fC-5dtuA:
undetectable
4v1fC-5dtuA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7j ATP-DEPENDENT RNA
HELICASE DDX3X


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLU A 285
ALA A 286
PHE A 289
AMP  A 801 ( 4.5A)
None
None
0.64A 4v1fC-5e7jA:
undetectable
4v1fC-5e7jA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1


(Homo sapiens)
PF00083
(Sugar_tr)
3 GLU A 380
ALA A 377
PHE A 379
5RH  A 501 ( 3.6A)
None
5RH  A 501 ( 4.5A)
0.65A 4v1fC-5eqiA:
undetectable
4v1fC-5eqiA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE


(Pyrococcus
horikoshii)
PF00004
(AAA)
3 GLU A 321
ALA A 322
PHE A 325
None
0.62A 4v1fC-5eqtA:
undetectable
4v1fC-5eqtA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gli ENDOTHELIN RECEPTOR
SUBTYPE-B


(Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
3 GLU A 236
ALA A 237
PHE A 240
None
0.23A 4v1fC-5gliA:
undetectable
4v1fC-5gliA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht0 AMINOGLYCOSIDE
ACETYLTRANSFERASE
HMB0005


(uncultured
bacterium)
PF02522
(Antibiotic_NAT)
3 GLU A 124
ALA A 125
PHE A 128
None
0.63A 4v1fC-5ht0A:
undetectable
4v1fC-5ht0A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iof SULPHATE TRANSPORTER

(Deinococcus
geothermalis)
PF00916
(Sulfate_transp)
3 GLU A  38
ALA A  39
PHE A  42
None
0.47A 4v1fC-5iofA:
undetectable
4v1fC-5iofA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6w PROTEIN SIDEKICK-1

(Mus musculus)
PF07679
(I-set)
PF13927
(Ig_3)
3 GLU A 368
ALA A 362
PHE A 361
SO4  A 509 (-3.4A)
None
SO4  A 509 ( 4.1A)
0.62A 4v1fC-5k6wA:
undetectable
4v1fC-5k6wA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k70 PROTEIN SIDEKICK-2

(Mus musculus)
PF07679
(I-set)
PF13927
(Ig_3)
3 GLU A 368
ALA A 362
PHE A 361
None
0.56A 4v1fC-5k70A:
undetectable
4v1fC-5k70A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
3 GLU A1403
ALA A1674
PHE A1673
None
0.60A 4v1fC-5m5pA:
undetectable
4v1fC-5m5pA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN


(Thermothelomyces
thermophila)
PF07992
(Pyr_redox_2)
3 GLU A 577
ALA A 578
PHE A 581
None
0.44A 4v1fC-5mq6A:
undetectable
4v1fC-5mq6A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2j PROBABLE PHOSPHITE
TRANSPORT
SYSTEM-BINDING
PROTEIN PTXB


(Pseudomonas
stutzeri)
no annotation 3 GLU A  54
ALA A  55
PHE A  58
None
0.11A 4v1fC-5o2jA:
undetectable
4v1fC-5o2jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
3 GLU A 273
ALA A 274
PHE A 426
None
0.67A 4v1fC-5supA:
undetectable
4v1fC-5supA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2x UNCHARACTERIZED
PROTEIN LPG1670


(Legionella
pneumophila)
no annotation 3 GLU A 196
ALA A 197
PHE A 176
None
0.63A 4v1fC-5t2xA:
undetectable
4v1fC-5t2xA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis)
no annotation 3 GLU A 171
ALA A 102
PHE A 101
None
0.59A 4v1fC-5ta1A:
undetectable
4v1fC-5ta1A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY


(Burkholderia
ambifaria)
PF01546
(Peptidase_M20)
3 GLU A 122
ALA A  67
PHE A  66
EDO  A 505 (-2.7A)
None
EDO  A 505 ( 4.3A)
0.67A 4v1fC-5tp4A:
undetectable
4v1fC-5tp4A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tu4 PAGF
PRENYLTRANSFERASE


(Planktothrix
agardhii)
no annotation 3 GLU A 188
ALA A 187
PHE A 222
B1C  A 403 ( 4.2A)
None
DST  A 401 ( 4.5A)
0.66A 4v1fC-5tu4A:
undetectable
4v1fC-5tu4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0i GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL


(Homo sapiens)
PF12796
(Ank_2)
3 GLU A 626
ALA A 627
PHE A 630
None
0.48A 4v1fC-5u0iA:
undetectable
4v1fC-5u0iA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2


(Saccharomyces
cerevisiae)
no annotation 3 GLU A 221
ALA A 222
PHE A 225
None
0.35A 4v1fC-5vncA:
4.4
4v1fC-5vncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
PF03739
(YjgP_YjgQ)
3 GLU G  35
ALA G  48
PHE G  51
None
0.53A 4v1fC-5x5yG:
undetectable
4v1fC-5x5yG:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zom LA PROTEIN

(Trypanosoma
brucei)
no annotation 3 GLU A  74
ALA A  75
PHE A  78
None
0.57A 4v1fC-5zomA:
undetectable
4v1fC-5zomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhn METHYL-ACCEPTING
CHEMOTAXIS SENSORY
TRANSDUCER WITH
PHYTOCHROME SENSOR


(Nostoc
punctiforme)
no annotation 3 GLU A 637
ALA A 636
PHE A 634
None
None
CYC  A 800 (-3.9A)
0.62A 4v1fC-6bhnA:
undetectable
4v1fC-6bhnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6v TELOMERASE REVERSE
TRANSCRIPTASE


(Tetrahymena
thermophila)
no annotation 3 GLU A1086
ALA A1087
PHE A1090
None
0.38A 4v1fC-6d6vA:
undetectable
4v1fC-6d6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL


(Danio rerio)
no annotation 3 GLU A 269
ALA A 268
PHE A 281
None
0.67A 4v1fC-6enxA:
undetectable
4v1fC-6enxA:
16.61