SIMILAR PATTERNS OF AMINO ACIDS FOR 4V1F_C_BQ1C1087_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1att | ANTITHROMBIN III (Bos taurus) |
PF00079(Serpin) | 3 | GLU A 382ALA A 383PHE A 373 | None | 0.67A | 4v1fC-1attA:undetectable | 4v1fC-1attA:11.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bry | BRYODIN I (Bryonia dioica) |
PF00161(RIP) | 3 | GLU Y 90ALA Y 91PHE Y 94 | None | 0.60A | 4v1fC-1bryY:undetectable | 4v1fC-1bryY:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dm0 | SHIGA TOXIN ASUBUNIT (Shigelladysenteriae) |
PF00161(RIP) | 3 | GLU A 167ALA A 168PHE A 171 | None | 0.56A | 4v1fC-1dm0A:0.0 | 4v1fC-1dm0A:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezi | CMP-N-ACETYLNEURAMINIC ACID SYNTHETASE (Neisseriameningitidis) |
PF02348(CTP_transf_3) | 3 | GLU A 60ALA A 61PHE A 64 | None | 0.58A | 4v1fC-1eziA:undetectable | 4v1fC-1eziA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ggp | PROTEIN (LECTIN 1 ACHAIN) (Trichosantheskirilowii) |
PF00161(RIP) | 3 | GLU A 164ALA A 165PHE A 168 | None | 0.63A | 4v1fC-1ggpA:undetectable | 4v1fC-1ggpA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kjv | MATURE ALPHA CHAINOF MAJORHISTOCOMPATIBILITYCOMPLEX CLASS IANTIGEN (HEAVYCHAIN) (Rattusnorvegicus) |
PF00129(MHC_I)PF07654(C1-set) | 3 | GLU A 114ALA A 125PHE A 116 | None | 0.66A | 4v1fC-1kjvA:0.7 | 4v1fC-1kjvA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lln | ANTIVIRAL PROTEIN 3 (Phytolaccaamericana) |
PF00161(RIP) | 3 | GLU A 172ALA A 173PHE A 176 | None | 0.50A | 4v1fC-1llnA:0.2 | 4v1fC-1llnA:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lns | X-PROLYL DIPEPTIDYLAMINOPEPTIDASE (Lactococcuslactis) |
PF02129(Peptidase_S15)PF08530(PepX_C)PF09168(PepX_N) | 3 | GLU A 746ALA A 568PHE A 567 | None | 0.66A | 4v1fC-1lnsA:undetectable | 4v1fC-1lnsA:8.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lpc | DIANTHIN 30 (Dianthuscaryophyllus) |
PF00161(RIP) | 3 | GLU A 177ALA A 178PHE A 181 | CMP A 901 (-3.9A)NoneNone | 0.49A | 4v1fC-1lpcA:0.0 | 4v1fC-1lpcA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o8c | YHDH (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | GLU A 302ALA A 303PHE A 306 | None | 0.63A | 4v1fC-1o8cA:undetectable | 4v1fC-1o8cA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qcj | POKEWEED ANTIVIRALPROTEIN (Phytolaccaamericana) |
PF00161(RIP) | 3 | GLU A 176ALA A 177PHE A 180 | APT A 901 ( 3.6A)NoneNone | 0.62A | 4v1fC-1qcjA:undetectable | 4v1fC-1qcjA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r4p | SHIGA-LIKE TOXINTYPE II A SUBUNIT (Escherichiacoli) |
PF00161(RIP) | 3 | GLU A 167ALA A 168PHE A 171 | None | 0.58A | 4v1fC-1r4pA:undetectable | 4v1fC-1r4pA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rw2 | ATP-DEPENDENT DNAHELICASE II, 80 KDASUBUNIT (Homo sapiens) |
PF08785(Ku_PK_bind) | 3 | GLU A 87ALA A 88PHE A 91 | None | 0.37A | 4v1fC-1rw2A:undetectable | 4v1fC-1rw2A:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sy7 | CATALASE 1 (Neurosporacrassa) |
PF00199(Catalase)PF01965(DJ-1_PfpI)PF06628(Catalase-rel) | 3 | GLU A 307ALA A 306PHE A 252 | None | 0.62A | 4v1fC-1sy7A:undetectable | 4v1fC-1sy7A:8.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uai | POLYGULURONATE LYASE (Corynebacteriumsp.) |
PF08787(Alginate_lyase2) | 3 | GLU A 101ALA A 102PHE A 103 | None | 0.64A | 4v1fC-1uaiA:undetectable | 4v1fC-1uaiA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ukr | ENDO-1,4-B-XYLANASEI (Aspergillusniger) |
PF00457(Glyco_hydro_11) | 3 | GLU A 79ALA A 78PHE A 127 | None | 0.63A | 4v1fC-1ukrA:undetectable | 4v1fC-1ukrA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y13 | 6-PYRUVOYLTETRAHYDROPTERINSYNTHASE (Plasmodiumfalciparum) |
PF01242(PTPS) | 3 | GLU A 38ALA A 32PHE A 36 | BIO A 175 (-2.6A)NoneNone | 0.67A | 4v1fC-1y13A:undetectable | 4v1fC-1y13A:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a0s | 6-PYRUVOYLTETRAHYDROPTERINSYNTHASE (Plasmodiumvivax) |
PF01242(PTPS) | 3 | GLU A 45ALA A 39PHE A 43 | BIO A 282 (-3.1A)NoneNone | 0.58A | 4v1fC-2a0sA:undetectable | 4v1fC-2a0sA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ap1 | PUTATIVE REGULATORPROTEIN (Salmonellaenterica) |
PF00480(ROK) | 3 | GLU A 113ALA A 114PHE A 119 | None | 0.50A | 4v1fC-2ap1A:undetectable | 4v1fC-2ap1A:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bi7 | UDP-GALACTOPYRANOSEMUTASE (Klebsiellapneumoniae) |
PF03275(GLF)PF13450(NAD_binding_8) | 3 | GLU A 138ALA A 139PHE A 142 | None | 0.67A | 4v1fC-2bi7A:undetectable | 4v1fC-2bi7A:11.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 3 | GLU A 117ALA A 118PHE A 121 | None | 0.59A | 4v1fC-2bvgA:undetectable | 4v1fC-2bvgA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2db3 | ATP-DEPENDENT RNAHELICASE VASA (Drosophilamelanogaster) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLU A 337ALA A 338PHE A 341 | ANP A2901 ( 4.6A)NoneNone | 0.40A | 4v1fC-2db3A:undetectable | 4v1fC-2db3A:11.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5x | RIBOSOME-INACTIVATING PROTEIN (Silenechalcedonica) |
PF00161(RIP) | 3 | GLU A 170ALA A 171PHE A 174 | None | 0.58A | 4v1fC-2g5xA:undetectable | 4v1fC-2g5xA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9u | CYTOSINE/GUANINEDEAMINASE RELATEDPROTEIN (Clostridiumacetobutylicum) |
PF01979(Amidohydro_1) | 3 | GLU A 101ALA A 103PHE A 105 | None | 0.66A | 4v1fC-2i9uA:undetectable | 4v1fC-2i9uA:10.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jex | REGULATORY PROTEINE2 (Deltapapillomavirus4) |
PF00508(PPV_E2_N) | 3 | GLU A 176ALA A 177PHE A 180 | None | 0.46A | 4v1fC-2jexA:2.8 | 4v1fC-2jexA:17.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pjw | UNCHARACTERIZEDPROTEIN YHL002W (Saccharomycescerevisiae) |
no annotation | 3 | GLU H 289ALA H 290PHE H 293 | None | 0.65A | 4v1fC-2pjwH:3.4 | 4v1fC-2pjwH:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8w | POKEWEED ANTIVIRALPROTEIN (Phytolaccaacinosa) |
PF00161(RIP) | 3 | GLU A 175ALA A 176PHE A 179 | None | 0.64A | 4v1fC-2q8wA:undetectable | 4v1fC-2q8wA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qes | RIBOSOME-INACTIVATING PROTEIN PD-L4 (Phytolaccadioica) |
PF00161(RIP) | 3 | GLU A 175ALA A 176PHE A 179 | ADE A 501 ( 4.7A)NoneNone | 0.60A | 4v1fC-2qesA:undetectable | 4v1fC-2qesA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vda | TRANSLOCASE SUBUNITSECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 3 | GLU A 218ALA A 219PHE A 377 | None | 0.48A | 4v1fC-2vdaA:3.5 | 4v1fC-2vdaA:9.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vko | TM1634 (Thermotogamaritima) |
no annotation | 3 | GLU A 94ALA A 95PHE A 98 | None | 0.64A | 4v1fC-2vkoA:undetectable | 4v1fC-2vkoA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vlc | TYPE 2RIBOSOME-INACTIVATING PROTEIN CINNAMOMINIII (Cinnamomumcamphora) |
PF00161(RIP)PF00652(Ricin_B_lectin) | 3 | GLU A 167ALA A 168PHE A 171 | None | 0.66A | 4v1fC-2vlcA:undetectable | 4v1fC-2vlcA:10.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zr1 | AGGLUTININ-1 CHAIN A (Abrusprecatorius) |
PF00161(RIP) | 3 | GLU A 163ALA A 164PHE A 167 | None | 0.59A | 4v1fC-2zr1A:undetectable | 4v1fC-2zr1A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aex | THREONINE SYNTHASE (Thermusthermophilus) |
PF00291(PALP) | 3 | GLU A 264ALA A 265PHE A 217 | None | 0.60A | 4v1fC-3aexA:undetectable | 4v1fC-3aexA:13.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cma | 50S RIBOSOMALPROTEIN L32E (Haloarculamarismortui) |
PF01655(Ribosomal_L32e) | 3 | GLU Y 165ALA Y 166PHE Y 168 | G 01089 ( 3.7A) G 01269 ( 3.3A) A 01090 ( 3.7A) | 0.63A | 4v1fC-3cmaY:undetectable | 4v1fC-3cmaY:18.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctk | RRNA N-GLYCOSIDASE (Bougainvilleaspectabilis) |
PF00161(RIP) | 3 | GLU A 165ALA A 166PHE A 169 | None | 0.58A | 4v1fC-3ctkA:undetectable | 4v1fC-3ctkA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dah | RIBOSE-PHOSPHATEPYROPHOSPHOKINASE (Burkholderiapseudomallei) |
PF13793(Pribosyltran_N)PF14572(Pribosyl_synth) | 3 | GLU A 270ALA A 248PHE A 247 | None | 0.66A | 4v1fC-3dahA:undetectable | 4v1fC-3dahA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e60 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN ]SYNTHASE II (Bartonellahenselae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 3 | GLU A 264ALA A 263PHE A 418 | None | 0.63A | 4v1fC-3e60A:undetectable | 4v1fC-3e60A:13.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h5k | RIBOSOME-INACTIVATING PROTEINPD-L1/PD-L2 (Phytolaccadioica) |
PF00161(RIP) | 3 | GLU A 175ALA A 176PHE A 179 | None | 0.60A | 4v1fC-3h5kA:undetectable | 4v1fC-3h5kA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hiq | VACUOLAR SAPORIN (Saponariaofficinalis) |
PF00161(RIP) | 3 | GLU A 174ALA A 175PHE A 178 | None | 0.60A | 4v1fC-3hiqA:undetectable | 4v1fC-3hiqA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hiw | VACUOLAR SAPORIN (Saponariaofficinalis) |
PF00161(RIP) | 3 | GLU A 174ALA A 175PHE A 178 | C2X A 260 (-3.0A)NoneNone | 0.59A | 4v1fC-3hiwA:undetectable | 4v1fC-3hiwA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8z | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | GLU A 415ALA A 416PHE A 419 | None | 0.52A | 4v1fC-3k8zA:undetectable | 4v1fC-3k8zA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ku0 | RIBOSOME-INACTIVATING PROTEIN GELONIN (Suregadamultiflora) |
PF00161(RIP) | 3 | GLU A 166ALA A 167PHE A 170 | ADE A 800 ( 4.5A)NoneNone | 0.62A | 4v1fC-3ku0A:undetectable | 4v1fC-3ku0A:15.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m4f | ENDO-1,4-BETA-XYLANASE (Acidomycesacidophilus) |
PF00457(Glyco_hydro_11) | 3 | GLU A 102ALA A 101PHE A 150 | None | 0.66A | 4v1fC-3m4fA:undetectable | 4v1fC-3m4fA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7b | RIBOSOME BIOGENESISNEP1 RNAMETHYLTRANSFERASE (Archaeoglobusfulgidus) |
PF03587(EMG1) | 3 | GLU A 9ALA A 10PHE A 171 | NoneNoneSAH A 301 (-4.3A) | 0.65A | 4v1fC-3o7bA:undetectable | 4v1fC-3o7bA:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q6t | 43.2 KDA SALIVARYPROTEIN (Lutzomyialongipalpis) |
PF03022(MRJP) | 3 | GLU A 57ALA A 56PHE A 41 | None | 0.62A | 4v1fC-3q6tA:undetectable | 4v1fC-3q6tA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rwk | INULINASE (Aspergillusficuum) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | GLU X 97ALA X 98PHE X 99 | NoneNoneFRU X 801 (-4.0A) | 0.56A | 4v1fC-3rwkX:undetectable | 4v1fC-3rwkX:10.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujh | GLUCOSE-6-PHOSPHATEISOMERASE (Toxoplasmagondii) |
PF00342(PGI) | 3 | GLU A 409ALA A 342PHE A 384 | None | 0.63A | 4v1fC-3ujhA:undetectable | 4v1fC-3ujhA:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w2z | METHYL-ACCEPTINGCHEMOTAXIS PROTEIN (Nostoc sp. PCC7120) |
PF01590(GAF) | 3 | GLU A 144ALA A 143PHE A 141 | None | 0.67A | 4v1fC-3w2zA:undetectable | 4v1fC-3w2zA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wdq | BETA-MANNANASE (Symbioticprotist ofReticulitermessperatus) |
PF02156(Glyco_hydro_26) | 3 | GLU A 191ALA A 192PHE A 197 | None | 0.50A | 4v1fC-3wdqA:undetectable | 4v1fC-3wdqA:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wiw | GLYCOSYL HYDROLASEFAMILY 88 (Pedobacterheparinus) |
PF07470(Glyco_hydro_88) | 3 | GLU A 97ALA A 98PHE A 101 | None | 0.22A | 4v1fC-3wiwA:undetectable | 4v1fC-3wiwA:11.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wt0 | CELL DIVISIONPROTEIN FTSA (Staphylococcusaureus) |
PF02491(SHS2_FTSA)PF14450(FtsA) | 3 | GLU A 294ALA A 260PHE A 261 | None | 0.67A | 4v1fC-3wt0A:undetectable | 4v1fC-3wt0A:11.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zm8 | GH26ENDO-BETA-1,4-MANNANASE (Podosporaanserina) |
PF02156(Glyco_hydro_26)PF16990(CBM_35) | 3 | GLU A 300ALA A 301PHE A 306 | TLA A1452 (-2.8A)NoneNone | 0.52A | 4v1fC-3zm8A:undetectable | 4v1fC-3zm8A:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cng | SPOU RRNA METHYLASE (Sulfolobusacidocaldarius) |
PF00588(SpoU_methylase) | 3 | GLU A 42ALA A 43PHE A 46 | None | 0.63A | 4v1fC-4cngA:undetectable | 4v1fC-4cngA:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d25 | BMVLG PROTEIN (Bombyx mori) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLU A 276ALA A 277PHE A 280 | ANP A1564 ( 4.5A)NoneNone | 0.28A | 4v1fC-4d25A:undetectable | 4v1fC-4d25A:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dal | PUTATIVE ALDEHYDEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 3 | GLU A 77ALA A 78PHE A 81 | None | 0.66A | 4v1fC-4dalA:undetectable | 4v1fC-4dalA:11.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ejy | 3-METHYLADENINE DNAGLYCOSYLASE (Caldanaerobactersubterraneus) |
PF00730(HhH-GPD)PF07934(OGG_N) | 3 | GLU A 99ALA A 100PHE A 103 | None | 0.51A | 4v1fC-4ejyA:undetectable | 4v1fC-4ejyA:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4z | DNA POLYMERASE IV (Sulfolobusacidocaldarius;Sulfolobussolfataricus) |
no annotation | 3 | GLU B 49ALA B 50PHE B 53 | None | 0.64A | 4v1fC-4f4zB:undetectable | 4v1fC-4f4zB:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fbh | PROTEIN SYNTHESISINHIBITOR I (Hordeum vulgare) |
PF00161(RIP) | 3 | GLU A 175ALA A 176PHE A 179 | AMP A 301 ( 4.8A)NoneNone | 0.54A | 4v1fC-4fbhA:undetectable | 4v1fC-4fbhA:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvl | MEMBRANE-ANCHOREDMYCOSIN MYCP1 (Mycolicibacteriumthermoresistibile) |
PF00082(Peptidase_S8) | 3 | GLU A 76ALA A 77PHE A 80 | None | 0.64A | 4v1fC-4hvlA:undetectable | 4v1fC-4hvlA:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jb6 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Pseudomonasaeruginosa) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 3 | GLU A 257ALA A 256PHE A 412 | None | 0.61A | 4v1fC-4jb6A:undetectable | 4v1fC-4jb6A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ln9 | RIFAMYCIN POLYKETIDESYNTHASE (Amycolatopsismediterranei) |
PF14765(PS-DH) | 3 | GLU A 208ALA A 209PHE A 212 | None | 0.65A | 4v1fC-4ln9A:undetectable | 4v1fC-4ln9A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz1 | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Campylobacterjejuni) |
PF00478(IMPDH) | 3 | GLU A 323ALA A 324PHE A 327 | None | 0.62A | 4v1fC-4mz1A:undetectable | 4v1fC-4mz1A:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9d | RIK1-ASSOCIATEDFACTOR 1 (Schizosaccharomycespombe) |
no annotation | 3 | GLU B 444ALA B 445PHE B 446 | None | 0.63A | 4v1fC-4o9dB:undetectable | 4v1fC-4o9dB:13.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oky | RESTRICTIONENDONUCLEASE PVURTS1I (Proteusvulgaris) |
no annotation | 3 | GLU C 239ALA C 266PHE C 279 | None | 0.66A | 4v1fC-4okyC:undetectable | 4v1fC-4okyC:12.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4px9 | ATP-DEPENDENT RNAHELICASE DDX3X (Homo sapiens) |
PF00270(DEAD) | 3 | GLU A 285ALA A 286PHE A 289 | ADP A 601 ( 4.4A)NoneNone | 0.63A | 4v1fC-4px9A:undetectable | 4v1fC-4px9A:15.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4v1g | F0F1 ATP SYNTHASESUBUNIT C (Mycolicibacteriumphlei) |
PF00137(ATP-synt_C) | 3 | GLU A 65ALA A 66PHE A 69 | None | 0.01A | 4v1fC-4v1gA:14.1 | 4v1fC-4v1gA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ydw | DARPIN 44C12V5 (syntheticconstruct) |
PF12796(Ank_2)PF13637(Ank_4) | 3 | GLU A 56ALA A 87PHE A 89 | None | 0.52A | 4v1fC-4ydwA:undetectable | 4v1fC-4ydwA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yzz | TRAP TRANSPORTERSOLUTE BINDINGPROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 3 | GLU A 343ALA A 344PHE A 347 | None | 0.25A | 4v1fC-4yzzA:undetectable | 4v1fC-4yzzA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a15 | BTB/POZDOMAIN-CONTAININGPROTEIN KCTD16 (Homo sapiens) |
PF02214(BTB_2) | 3 | GLU A 109ALA A 110PHE A 113 | None | 0.37A | 4v1fC-5a15A:undetectable | 4v1fC-5a15A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bxd | BTB/POZDOMAIN-CONTAININGPROTEIN KCTD1 (Homo sapiens) |
PF02214(BTB_2) | 3 | GLU A 111ALA A 112PHE A 115 | None | 0.38A | 4v1fC-5bxdA:undetectable | 4v1fC-5bxdA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bxh | BTB/POZDOMAIN-CONTAININGPROTEIN KCTD9 (Homo sapiens) |
PF02214(BTB_2) | 3 | GLU A 86ALA A 87PHE A 90 | None | 0.29A | 4v1fC-5bxhA:undetectable | 4v1fC-5bxhA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c05 | PUTATIVEGAMMA-TERPINENESYNTHASE (Thymus vulgaris) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 3 | GLU A 255ALA A 256PHE A 259 | GLU A 255 ( 0.5A)ALA A 256 ( 0.0A)PHE A 259 (-1.3A) | 0.58A | 4v1fC-5c05A:undetectable | 4v1fC-5c05A:9.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cjj | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE (Campylobacterjejuni) |
PF00551(Formyl_trans_N) | 3 | GLU A 17ALA A 51PHE A 54 | None | 0.50A | 4v1fC-5cjjA:undetectable | 4v1fC-5cjjA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5da0 | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp)PF01740(STAS) | 3 | GLU A 38ALA A 39PHE A 42 | None | 0.47A | 4v1fC-5da0A:undetectable | 4v1fC-5da0A:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ddz | RICIN (Ricinuscommunis) |
PF00161(RIP) | 3 | GLU A 177ALA A 178PHE A 181 | None | 0.49A | 4v1fC-5ddzA:undetectable | 4v1fC-5ddzA:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dse | TETRATRICOPEPTIDEREPEAT PROTEIN 7B (Homo sapiens) |
PF12895(ANAPC3)PF13181(TPR_8)PF13424(TPR_12) | 3 | GLU A 450ALA A 451PHE A 454 | None | 0.59A | 4v1fC-5dseA:undetectable | 4v1fC-5dseA:7.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dtu | PRP28 (Chaetomiumthermophilum) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLU A 371ALA A 372PHE A 375 | ADP A 801 ( 3.7A)NoneNone | 0.49A | 4v1fC-5dtuA:undetectable | 4v1fC-5dtuA:12.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7j | ATP-DEPENDENT RNAHELICASE DDX3X (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLU A 285ALA A 286PHE A 289 | AMP A 801 ( 4.5A)NoneNone | 0.64A | 4v1fC-5e7jA:undetectable | 4v1fC-5e7jA:9.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eqi | SOLUTE CARRIERFAMILY 2,FACILITATED GLUCOSETRANSPORTER MEMBER 1 (Homo sapiens) |
PF00083(Sugar_tr) | 3 | GLU A 380ALA A 377PHE A 379 | 5RH A 501 ( 3.6A)None5RH A 501 ( 4.5A) | 0.65A | 4v1fC-5eqiA:undetectable | 4v1fC-5eqiA:11.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eqt | PROTEASOME-ACTIVATING NUCLEOTIDASE (Pyrococcushorikoshii) |
PF00004(AAA) | 3 | GLU A 321ALA A 322PHE A 325 | None | 0.62A | 4v1fC-5eqtA:undetectable | 4v1fC-5eqtA:16.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gli | ENDOTHELIN RECEPTORSUBTYPE-B (Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | GLU A 236ALA A 237PHE A 240 | None | 0.23A | 4v1fC-5gliA:undetectable | 4v1fC-5gliA:12.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ht0 | AMINOGLYCOSIDEACETYLTRANSFERASEHMB0005 (unculturedbacterium) |
PF02522(Antibiotic_NAT) | 3 | GLU A 124ALA A 125PHE A 128 | None | 0.63A | 4v1fC-5ht0A:undetectable | 4v1fC-5ht0A:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iof | SULPHATE TRANSPORTER (Deinococcusgeothermalis) |
PF00916(Sulfate_transp) | 3 | GLU A 38ALA A 39PHE A 42 | None | 0.47A | 4v1fC-5iofA:undetectable | 4v1fC-5iofA:11.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k6w | PROTEIN SIDEKICK-1 (Mus musculus) |
PF07679(I-set)PF13927(Ig_3) | 3 | GLU A 368ALA A 362PHE A 361 | SO4 A 509 (-3.4A)NoneSO4 A 509 ( 4.1A) | 0.62A | 4v1fC-5k6wA:undetectable | 4v1fC-5k6wA:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k70 | PROTEIN SIDEKICK-2 (Mus musculus) |
PF07679(I-set)PF13927(Ig_3) | 3 | GLU A 368ALA A 362PHE A 361 | None | 0.56A | 4v1fC-5k70A:undetectable | 4v1fC-5k70A:15.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m5p | PRE-MRNA-SPLICINGHELICASE BRR2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | GLU A1403ALA A1674PHE A1673 | None | 0.60A | 4v1fC-5m5pA:undetectable | 4v1fC-5m5pA:4.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mq6 | PYRIDINENUCLEOTIDE-DISULFIDEOXIDOREDUCTASE-LIKEPROTEIN (Thermothelomycesthermophila) |
PF07992(Pyr_redox_2) | 3 | GLU A 577ALA A 578PHE A 581 | None | 0.44A | 4v1fC-5mq6A:undetectable | 4v1fC-5mq6A:9.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o2j | PROBABLE PHOSPHITETRANSPORTSYSTEM-BINDINGPROTEIN PTXB (Pseudomonasstutzeri) |
no annotation | 3 | GLU A 54ALA A 55PHE A 58 | None | 0.11A | 4v1fC-5o2jA:undetectable | 4v1fC-5o2jA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sup | ATP-DEPENDENT RNAHELICASE SUB2 (Saccharomycescerevisiae) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | GLU A 273ALA A 274PHE A 426 | None | 0.67A | 4v1fC-5supA:undetectable | 4v1fC-5supA:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5t2x | UNCHARACTERIZEDPROTEIN LPG1670 (Legionellapneumophila) |
no annotation | 3 | GLU A 196ALA A 197PHE A 176 | None | 0.63A | 4v1fC-5t2xA:undetectable | 4v1fC-5t2xA:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ta1 | GLYCOSIDE HYDROLASE (Bacteroidesuniformis) |
no annotation | 3 | GLU A 171ALA A 102PHE A 101 | None | 0.59A | 4v1fC-5ta1A:undetectable | 4v1fC-5ta1A:9.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tp4 | AMIDASE,HYDANTOINASE/CARBAMOYLASE FAMILY (Burkholderiaambifaria) |
PF01546(Peptidase_M20) | 3 | GLU A 122ALA A 67PHE A 66 | EDO A 505 (-2.7A)NoneEDO A 505 ( 4.3A) | 0.67A | 4v1fC-5tp4A:undetectable | 4v1fC-5tp4A:12.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tu4 | PAGFPRENYLTRANSFERASE (Planktothrixagardhii) |
no annotation | 3 | GLU A 188ALA A 187PHE A 222 | B1C A 403 ( 4.2A)NoneDST A 401 ( 4.5A) | 0.66A | 4v1fC-5tu4A:undetectable | 4v1fC-5tu4A:15.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u0i | GLUTAMINASE KIDNEYISOFORM,MITOCHONDRIAL (Homo sapiens) |
PF12796(Ank_2) | 3 | GLU A 626ALA A 627PHE A 630 | None | 0.48A | 4v1fC-5u0iA:undetectable | 4v1fC-5u0iA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vnc | GLYCOGEN [STARCH]SYNTHASE ISOFORM 2 (Saccharomycescerevisiae) |
no annotation | 3 | GLU A 221ALA A 222PHE A 225 | None | 0.35A | 4v1fC-5vncA:4.4 | 4v1fC-5vncA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x5y | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF03739(YjgP_YjgQ) | 3 | GLU G 35ALA G 48PHE G 51 | None | 0.53A | 4v1fC-5x5yG:undetectable | 4v1fC-5x5yG:15.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zom | LA PROTEIN (Trypanosomabrucei) |
no annotation | 3 | GLU A 74ALA A 75PHE A 78 | None | 0.57A | 4v1fC-5zomA:undetectable | 4v1fC-5zomA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhn | METHYL-ACCEPTINGCHEMOTAXIS SENSORYTRANSDUCER WITHPHYTOCHROME SENSOR (Nostocpunctiforme) |
no annotation | 3 | GLU A 637ALA A 636PHE A 634 | NoneNoneCYC A 800 (-3.9A) | 0.62A | 4v1fC-6bhnA:undetectable | 4v1fC-6bhnA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d6v | TELOMERASE REVERSETRANSCRIPTASE (Tetrahymenathermophila) |
no annotation | 3 | GLU A1086ALA A1087PHE A1090 | None | 0.38A | 4v1fC-6d6vA:undetectable | 4v1fC-6d6vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6enx | NAD-DEPENDENTPROTEIN DEACYLASESIRTUIN-5,MITOCHONDRIAL (Danio rerio) |
no annotation | 3 | GLU A 269ALA A 268PHE A 281 | None | 0.67A | 4v1fC-6enxA:undetectable | 4v1fC-6enxA:16.61 |