SIMILAR PATTERNS OF AMINO ACIDS FOR 4V04_B_0LIB1771_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsc ACETOHYDROXY-ACID
SYNTHASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 389
VAL A 364
LEU A 320
ALA A 372
PHE A 377
 None
 0.87A 4v04B-1jscA:
undetectable		 4v04B-1jscA:
19.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
LEU A 715
HIS A 722
ALA A 741
ASP A 742
 None
 0.64A 4v04B-1lufA:
34.4		 4v04B-1lufA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyq THREONYL-TRNA
SYNTHETASE 1

(Staphylococcus
aureus) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		5 ALA A 489
VAL A 403
ALA A 450
ASP A 452
GLY A 455
 None
 0.93A 4v04B-1nyqA:
undetectable		 4v04B-1nyqA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 288
GLU A 305
LEU A 373
HIS A 380
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
None
P16  A   2 (-3.5A)
 0.63A 4v04B-1opkA:
29.8		 4v04B-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 230
GLU A 245
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.62A 4v04B-1py5A:
25.1		 4v04B-1py5A:
29.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 None
 1.04A 4v04B-1rjbA:
33.4		 4v04B-1rjbA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 621
GLU A 640
HIS A 790
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.80A 4v04B-1t46A:
28.7		 4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
GLU A 640
LEU A 783
CYH A 788
HIS A 790
ASP A 810
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
 0.71A 4v04B-1t46A:
28.7		 4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 367
GLU A 386
ALA A 417
LEU A 452
HIS A 459
 STU  A 100 (-3.2A)
None
STU  A 100 (-3.7A)
None
None
 0.68A 4v04B-1u59A:
31.0		 4v04B-1u59A:
35.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
GLU A 286
LEU A 354
HIS A 361
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.91A 4v04B-2hz0A:
30.2		 4v04B-2hz0A:
40.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
GLU A 288
HIS A 362
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.49A 4v04B-2og8A:
31.4		 4v04B-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 614
GLU A 633
LEU A 769
HIS A 776
ASP A 796
 None
 0.81A 4v04B-2ogvA:
33.1		 4v04B-2ogvA:
47.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ALA A 367
ALA A 417
LEU A 452
HIS A 459
GLY A 481
 ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
None
None
None
 0.70A 4v04B-2ozoA:
28.1		 4v04B-2ozoA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
ALA A 905
LEU A 955
HIS A 962
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-3.6A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.51A 4v04B-2p4iA:
26.4		 4v04B-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 905
LEU A 955
HIS A 962
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.6A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 1.35A 4v04B-2p4iA:
26.4		 4v04B-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 515
GLU A 534
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 None
 0.73A 4v04B-2psqA:
36.2		 4v04B-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
VAL A 564
ALA A 567
HIS A 624
ALA A 643
GLY A 646
 None
 1.25A 4v04B-2psqA:
36.2		 4v04B-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 215
GLU A 230
LEU A 301
HIS A 319
ALA A 338
 ADE  A 488 (-3.2A)
None
None
None
None
 0.90A 4v04B-2qluA:
24.4		 4v04B-2qluA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		6 ALA B1836
ALA B1834
LEU B1929
HIS B1755
ALA B1877
GLY B1757
 None
 1.38A 4v04B-2r7eB:
undetectable		 4v04B-2r7eB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ALA A 218
GLU A 230
VAL A 285
ALA A 220
LEU A 189
ASP A 226
 None
 1.13A 4v04B-2vk4A:
undetectable		 4v04B-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.61A 4v04B-2xikA:
18.6		 4v04B-2xikA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 273
GLU A 290
HIS A 365
ALA A 384
ASP A 385
GLY A 387
 None
 1.46A 4v04B-2zv7A:
31.2		 4v04B-2zv7A:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
 M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
 1.05A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
 0.93A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
 0.86A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
VAL A 564
ALA A 567
HIS A 624
ALA A 643
GLY A 646
 M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
None
 1.20A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
None
None
 0.63A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1108
GLU A1127
LEU A1195
HIS A1202
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.89A 4v04B-3c1xA:
26.4		 4v04B-3c1xA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
PHE A 489
GLY A 643
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
None
 0.66A 4v04B-3c4fA:
42.4		 4v04B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
None
 0.56A 4v04B-3c4fA:
42.4		 4v04B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  44
LEU A 137
HIS A 144
ALA A 163
GLY A 166
 ANP  A   1 ( 3.9A)
None
None
MG  A 296 ( 3.9A)
None
 0.76A 4v04B-3dakA:
21.8		 4v04B-3dakA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		5 GLU A 558
ALA A 172
ALA A 522
PHE A 104
GLY A 525
 None
 0.92A 4v04B-3djaA:
undetectable		 4v04B-3djaA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 663
GLU A 682
LEU A 749
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.70A 4v04B-3dkoA:
31.9		 4v04B-3dkoA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 169
ALA A 223
LEU A 256
HIS A 266
ASP A 294
 VIN  A6331 (-3.4A)
VIN  A6331 (-3.8A)
None
None
VIN  A6331 (-4.0A)
 0.85A 4v04B-3dtcA:
26.6		 4v04B-3dtcA:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 859
GLU A 878
VAL A 909
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
8ST  A2001 ( 3.7A)
 0.75A 4v04B-3hngA:
35.0		 4v04B-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 859
GLU A 878
VAL A 909
LEU A1013
CYH A1018
HIS A1020
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 0.43A 4v04B-3hngA:
35.0		 4v04B-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		6 ALA A  12
VAL A 131
ALA A  10
ALA A 147
ASP A 146
PHE A 112
 None
 1.26A 4v04B-3hu5A:
undetectable		 4v04B-3hu5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ALA A  80
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 0.91A 4v04B-3iecA:
22.3		 4v04B-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.86A 4v04B-3lm5A:
24.1		 4v04B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ALA A 229
GLU A 244
LEU A 315
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.78A 4v04B-3mdyA:
24.8		 4v04B-3mdyA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
ALA A 162
HIS A 203
ASP A 223
GLY A 225
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
JOZ  A 361 (-3.8A)
None
SO4  A   5 ( 4.5A)
SO4  A   5 ( 4.6A)
 1.31A 4v04B-3nuuA:
23.4		 4v04B-3nuuA:
26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1112
LEU A1199
HIS A1206
ALA A1225
GLY A1228
 ANP  A1358 ( 3.8A)
None
None
None
None
 0.71A 4v04B-3plsA:
30.7		 4v04B-3plsA:
39.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
None
None
None
07J  A   1 (-3.2A)
None
 0.58A 4v04B-3tt0A:
41.4		 4v04B-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 570
LEU A 670
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.95A 4v04B-3v5qA:
31.9		 4v04B-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLU A 588
LEU A 670
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.6A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.76A 4v04B-3v5qA:
31.9		 4v04B-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
 0.84A 4v04B-3vidA:
35.3		 4v04B-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
 0.51A 4v04B-3vidA:
35.3		 4v04B-3vidA:
49.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vql SMALL HEAT SHOCK
PROTEIN STHSP14.0

(Sulfurisphaera
tokodaii) 		PF00011
(HSP20) 		5 ALA A  64
VAL A  83
ALA A  52
ALA A  40
ASP A  41
 None
 0.93A 4v04B-3vqlA:
undetectable		 4v04B-3vqlA:
16.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
None
 0.58A 4v04B-3wzdA:
29.4		 4v04B-3wzdA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzs UDP-GLUCOSE-GLYCOPRO
TEIN
GLUCOSYLTRANSFERASE-
LIKE PROTEIN

(Chaetomium
thermophilum) 		PF06427
(UDP-g_GGTase) 		6 ALA A 721
LEU A 788
HIS A 737
ALA A 707
ASP A 708
GLY A 800
 PQE  A2000 ( 4.2A)
None
None
None
None
None
 1.36A 4v04B-3wzsA:
undetectable		 4v04B-3wzsA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 0.93A 4v04B-4agdA:
35.5		 4v04B-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
None
 0.67A 4v04B-4agdA:
35.5		 4v04B-4agdA:
49.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  63
GLU A  81
LEU A 148
HIS A 155
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
None
XZN  A1317 ( 4.3A)
 0.89A 4v04B-4bc6A:
21.0		 4v04B-4bc6A:
28.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
GLU A 672
LEU A 757
HIS A 764
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.72A 4v04B-4ckrA:
31.4		 4v04B-4ckrA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 684
GLU A 705
ALA A 740
ALA A 799
ASP A 800
GLY A 802
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
None
 1.45A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  41
LEU A 136
HIS A 143
ALA A 162
GLY A 165
 0RS  A 900 ( 3.7A)
None
None
0RS  A 900 (-3.6A)
None
 0.73A 4v04B-4ez5A:
23.2		 4v04B-4ez5A:
26.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 400
GLU A 420
ALA A 451
LEU A 485
HIS A 492
 0SB  A 701 (-3.3A)
None
0SB  A 701 (-4.0A)
None
None
 0.86A 4v04B-4f4pA:
29.4		 4v04B-4f4pA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 MET A 562
LEU A 636
HIS A 643
ALA A 662
ASP A 663
 None
None
None
0T8  A 901 ( 4.5A)
0T8  A 901 (-4.5A)
 0.91A 4v04B-4feqA:
25.1		 4v04B-4feqA:
39.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ALA A 400
ALA A 451
LEU A 485
HIS A 492
GLY A 514
 ANP  A 701 (-3.3A)
ANP  A 701 (-4.1A)
None
None
None
 0.93A 4v04B-4fl3A:
29.4		 4v04B-4fl3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
GLU A  71
VAL A 100
LEU A 137
HIS A 144
 STU  A 401 (-3.2A)
None
None
None
None
 0.77A 4v04B-4fr4A:
21.1		 4v04B-4fr4A:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
GLU A 871
LEU A 940
CYH A 945
HIS A 947
ALA A 966
 19S  A1201 (-3.3A)
None
None
None
None
19S  A1201 ( 4.1A)
 0.65A 4v04B-4hviA:
29.8		 4v04B-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 506
GLU A 525
MET A 528
VAL A 555
ALA A 558
LEU A 608
HIS A 615
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
None
 0.93A 4v04B-4k33A:
29.3		 4v04B-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
GLU A 525
VAL A 555
ALA A 558
HIS A 615
ALA A 634
GLY A 637
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
None
 1.33A 4v04B-4k33A:
29.3		 4v04B-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
VAL A 555
ALA A 558
HIS A 615
ALA A 634
ASP A 635
GLY A 637
 ACP  A 801 (-3.3A)
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
MG  A 802 ( 3.0A)
None
 1.37A 4v04B-4k33A:
29.3		 4v04B-4k33A:
80.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA B  51
GLU B  70
HIS B 142
ALA B 161
ASP B 162
GLY B 164
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 3.4A)
None
 1.36A 4v04B-4o27B:
20.1		 4v04B-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA B  51
GLU B  70
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.64A 4v04B-4o27B:
20.1		 4v04B-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 ALA A  61
GLU A  94
MET A  97
HIS A 173
ASP A 193
 046  A 401 ( 4.6A)
046  A 401 (-3.7A)
046  A 401 (-3.9A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.91A 4v04B-4o2zA:
21.8		 4v04B-4o2zA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA B 390
VAL B 434
LEU B 475
HIS B 483
ALA B 502
 ACP  B 801 (-3.2A)
ACP  B 801 (-4.8A)
None
None
None
 0.89A 4v04B-4oavB:
17.7		 4v04B-4oavB:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
P30  A1001 ( 4.3A)
None
 0.82A 4v04B-4rt7A:
29.0		 4v04B-4rt7A:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.52A 4v04B-4tptA:
21.2		 4v04B-4tptA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		6 ALA A 293
ALA A 528
LEU A 399
ALA A 557
ASP A 394
GLY A 395
 None
 1.29A 4v04B-4tr2A:
undetectable		 4v04B-4tr2A:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
GLU A  52
HIS A 127
ALA A 146
ASP A 147
GLY A 149
 ACP  A1264 (-2.9A)
None
None
None
None
None
 1.38A 4v04B-4ueuA:
30.7		 4v04B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 169
ALA A 223
LEU A 256
HIS A 266
GLY A 296
 None
 0.74A 4v04B-4uy9A:
26.7		 4v04B-4uy9A:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 501
GLU A 520
VAL A 550
ALA A 553
LEU A 603
CYH A 608
HIS A 610
ALA A 629
GLY A 632
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
None
40M  A1002 (-3.0A)
None
 0.33A 4v04B-4xcuA:
38.7		 4v04B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
MET A 664
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.85A 4v04B-4xufA:
33.5		 4v04B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
None
P30  A1001 (-4.4A)
None
 0.71A 4v04B-4xufA:
33.5		 4v04B-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 488
GLU A 509
LEU A 577
HIS A 586
ALA A 605
 4CV  A 801 (-3.5A)
None
None
None
4CV  A 801 ( 3.9A)
 0.82A 4v04B-4yffA:
25.2		 4v04B-4yffA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
None
EDO  A1766 ( 4.4A)
EDO  A1766 (-3.6A)
 0.27A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp3 MYCOCEROSIC ACID
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF14765
(PS-DH) 		6 VAL A1094
LEU A 931
HIS A 934
ALA A 945
ASP A1100
PHE A1103
 None
None
EDO  A1202 (-4.3A)
None
None
None
 1.06A 4v04B-5bp3A:
undetectable		 4v04B-5bp3A:
23.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
None
 0.73A 4v04B-5fm2A:
34.0		 4v04B-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 625
GLU A 644
HIS A 816
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.87A 4v04B-5grnA:
26.2		 4v04B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
GLU A 644
LEU A 809
CYH A 814
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.52A 4v04B-5grnA:
26.2		 4v04B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A  43
ALA A  85
LEU A 121
HIS A 131
GLY A 153
 032  A 401 (-3.2A)
032  A 401 (-3.6A)
None
None
032  A 401 (-3.6A)
 0.50A 4v04B-5hesA:
20.4		 4v04B-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A  85
LEU A 121
HIS A 131
ASP A 151
GLY A 153
 032  A 401 (-3.6A)
None
None
032  A 401 (-4.6A)
032  A 401 (-3.6A)
 0.95A 4v04B-5hesA:
20.4		 4v04B-5hesA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmb AZI13

(Streptomyces
sahachiroi) 		PF03061
(4HBT) 		5 VAL A  15
ALA A  32
LEU A 129
ALA A  62
ASP A  65
 None
 0.86A 4v04B-5hmbA:
undetectable		 4v04B-5hmbA:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
LEU A1195
HIS A1202
ALA A1221
GLY A1224
 63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.3A)
None
 0.89A 4v04B-5horA:
26.5		 4v04B-5horA:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  50
GLU A  66
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.78A 4v04B-5idnA:
15.6		 4v04B-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  43
GLU A  61
LEU A 127
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 ( 4.2A)
 0.68A 4v04B-5j5tA:
21.2		 4v04B-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		5 ALA A 279
GLU A 333
VAL A 280
CYH A 678
ASP A 670
 None
 0.95A 4v04B-5jxfA:
undetectable		 4v04B-5jxfA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m45 ACETONE CARBOXYLASE
BETA SUBUNIT

(Xanthobacter
autotrophicus) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 ALA B 372
LEU B 448
HIS B 478
ALA B 352
GLY B 475
 None
None
None
AMP  B 801 (-3.2A)
None
 0.82A 4v04B-5m45B:
undetectable		 4v04B-5m45B:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE

(Pseudomonas
putida) 		PF01053
(Cys_Met_Meta_PP) 		6 VAL A 185
ALA A 160
LEU A 143
ALA A 167
ASP A 168
GLY A 171
 None
 1.22A 4v04B-5x2vA:
undetectable		 4v04B-5x2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 5 ALA A  95
ALA A 144
LEU A 187
HIS A 197
ALA A 216
 ANP  A1000 (-3.2A)
ANP  A1000 (-3.5A)
None
None
MG  A1001 ( 4.4A)
 0.83A 4v04B-5xd6A:
21.9		 4v04B-5xd6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 107
GLU A 124
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
None
None
EMH  A 705 ( 4.0A)
 0.61A 4v04B-5xv7A:
20.9		 4v04B-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 5 ALA A  54
LEU A 137
HIS A 144
ALA A 163
GLY A 166
 ANP  A 501 ( 3.7A)
None
None
None
None
 0.82A 4v04B-6ao5A:
22.1		 4v04B-6ao5A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ALA A  87
GLU A 107
ALA A 139
HIS A 180
ALA A 199
GLY A 202
 None
 1.39A 4v04B-6c9dA:
21.9		 4v04B-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
GLU A 236
LEU A 303
HIS A 310
ALA A 329
 F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
None
None
F6J  A 501 ( 4.0A)
 0.86A 4v04B-6cmjA:
21.9		 4v04B-6cmjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.61A 4v04B-6cnhA:
21.8		 4v04B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.73A 4v04B-6cnhA:
21.8		 4v04B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 ALA A 756
GLU A 775
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 0.90A 4v04B-6fekA:
33.3		 4v04B-6fekA:
18.64