SIMILAR PATTERNS OF AMINO ACIDS FOR 4V04_B_0LIB1771_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
LYS A 222
MET A 240
TYR A 268
ARG A 313
LEU A 321
 None
 1.04A 4v04B-1k9aA:
30.8		 4v04B-1k9aA:
29.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 588
LYS A 608
TYR A 656
ARG A 723
LEU A 731
ILE A 740
 None
 1.17A 4v04B-1lufA:
34.4		 4v04B-1lufA:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
LYS A 623
TYR A 672
ARG A 791
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.4A)
 1.09A 4v04B-1t46A:
28.7		 4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
LYS A 623
TYR A 672
LEU A 799
ILE A 653
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
None
 0.98A 4v04B-1t46A:
28.7		 4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
TYR A 672
ARG A 791
LEU A 799
ILE A 808
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.4A)
None
 0.83A 4v04B-1t46A:
28.7		 4v04B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
LYS A 369
MET A 390
LEU A 468
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-4.5A)
None
 0.59A 4v04B-1u59A:
31.0		 4v04B-1u59A:
35.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
LYS A  57
ILE A  89
TYR A 107
ARG A 150
LEU A 158
 None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.86A 4v04B-1u5qA:
24.1		 4v04B-1u5qA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
TYR A  86
ARG A 129
LEU A 137
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
None
 0.79A 4v04B-1zltA:
21.1		 4v04B-1zltA:
28.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU X  17
VAL X  25
LYS X  39
MET X  58
TYR X  84
ARG X 129
LEU X 137
ILE X 146
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
None
 1.10A 4v04B-2dq7X:
30.8		 4v04B-2dq7X:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
LYS A  57
ILE A  89
TYR A 107
ARG A 150
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 ( 4.5A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
SEP  A 181 ( 2.9A)
STU  A 400 ( 4.6A)
 0.88A 4v04B-2gcdA:
24.9		 4v04B-2gcdA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
LYS A 295
LEU A 393
ILE A 402
LEU A 407
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
None
QUE  A   1 (-4.4A)
None
None
 1.05A 4v04B-2hckA:
29.1		 4v04B-2hckA:
28.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
LYS A 273
MET A 292
LEU A 371
ILE A 380
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-4.4A)
None
 0.94A 4v04B-2hk5A:
24.7		 4v04B-2hk5A:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
VAL A  63
LYS A  78
ARG A 169
LEU A 177
ILE A 189
 None
 1.17A 4v04B-2hw6A:
19.9		 4v04B-2hw6A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
 0.95A 4v04B-2i0eA:
14.3		 4v04B-2i0eA:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
LYS A 273
MET A 292
ARG A 363
LEU A 371
ILE A 380
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.3A)
None
 1.45A 4v04B-2og8A:
31.4		 4v04B-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
MET A 292
TYR A 318
ARG A 363
LEU A 371
ILE A 380
 None
None
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.7A)
None
1N8  A 501 ( 4.3A)
None
 1.30A 4v04B-2og8A:
31.4		 4v04B-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
MET A 637
TYR A 665
ARG A 777
LEU A 785
ILE A 794
 None
 0.97A 4v04B-2ogvA:
33.1		 4v04B-2ogvA:
47.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
ARG A 460
LEU A 468
ILE A 477
LEU A 482
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
None
ANP  A 615 (-4.7A)
None
None
 0.78A 4v04B-2ozoA:
28.1		 4v04B-2ozoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
LYS A  48
ILE A  87
ARG A 148
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 1.15A 4v04B-2phkA:
22.1		 4v04B-2phkA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
MET A 538
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
None
 0.93A 4v04B-2psqA:
36.2		 4v04B-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU C  55
VAL C  63
LYS C  78
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
 0.75A 4v04B-2wtkC:
22.7		 4v04B-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL C  63
LYS C  78
ILE C 111
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
None
 0.84A 4v04B-2wtkC:
22.7		 4v04B-2wtkC:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 112
VAL A 120
MET A 155
ILE A 164
TYR A 182
ILE A 245
 16X  A1374 (-4.1A)
16X  A1374 (-4.8A)
None
None
16X  A1374 (-4.1A)
None
 0.89A 4v04B-2x4fA:
22.3		 4v04B-2x4fA:
24.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
LYS A 653
MET A 674
ILE A 683
TYR A 701
LEU A 753
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
 0.84A 4v04B-2xyuA:
28.1		 4v04B-2xyuA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
MET A 538
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
None
M33  A1996 (-4.5A)
None
 1.09A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
LYS A 517
MET A 538
ILE A 548
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.7A)
M33  A1996 ( 4.5A)
None
None
None
M33  A1996 (-4.5A)
None
 1.24A 4v04B-3b2tA:
28.5		 4v04B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
LYS A 514
MET A 535
ILE A 545
TYR A 563
LEU A 630
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
None
 0.55A 4v04B-3c4fA:
42.4		 4v04B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
LEU A 644
 C4F  A   1 ( 3.9A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
None
None
 0.42A 4v04B-3c4fA:
42.4		 4v04B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
LYS A 222
MET A 240
TYR A 268
ARG A 313
LEU A 321
 None
 1.04A 4v04B-3d7uA:
25.5		 4v04B-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 158
LYS A 171
ILE A 204
ARG A 267
LEU A 275
ILE A 292
 VIN  A6331 (-4.7A)
None
VIN  A6331 ( 4.9A)
None
VIN  A6331 (-4.5A)
None
 1.00A 4v04B-3dtcA:
26.6		 4v04B-3dtcA:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
LEU A 173
ILE A  62
 DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
None
 1.24A 4v04B-3eb0A:
20.8		 4v04B-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
LYS A  38
MET A  54
ILE A  63
TYR A 119
LEU A 173
 DRK  A 384 (-3.8A)
None
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
 0.82A 4v04B-3eb0A:
20.8		 4v04B-3eb0A:
23.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
VAL A 841
LYS A 861
TYR A 911
ARG A1021
LEU A1029
ILE A1038
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-4.9A)
None
None
None
 0.76A 4v04B-3hngA:
35.0		 4v04B-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  67
LYS A  82
MET A 104
TYR A 131
LEU A 182
ILE A 191
 None
 0.72A 4v04B-3iecA:
22.3		 4v04B-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 680
VAL A 689
ILE A 729
ARG A 796
LEU A 804
ILE A 826
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
None
 1.09A 4v04B-3lj0A:
22.1		 4v04B-3lj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
VAL A  47
LYS A  62
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.71A 4v04B-3lm5A:
24.1		 4v04B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  61
VAL A  69
ILE A 116
TYR A 134
LEU A 184
ILE A 193
 None
 0.90A 4v04B-3mn3A:
20.3		 4v04B-3mn3A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
VAL A  57
LYS A  72
TYR A 122
ARG A 165
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
TPO  A 197 ( 3.1A)
XFE  A 351 (-4.6A)
 1.02A 4v04B-3mvjA:
20.7		 4v04B-3mvjA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
LYS A 111
TYR A 161
ARG A 204
LEU A 212
ILE A 221
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
SO4  A   5 (-2.8A)
None
SEP  A 241 ( 3.4A)
None
None
 1.05A 4v04B-3nuuA:
23.4		 4v04B-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
MET A 134
TYR A 161
ARG A 204
LEU A 212
ILE A 221
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
None
None
SEP  A 241 ( 3.4A)
None
None
 0.93A 4v04B-3nuuA:
23.4		 4v04B-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.3A)
ANP  A 800 (-4.2A)
TPO  A 500 ( 2.9A)
None
 1.11A 4v04B-3pfqA:
19.6		 4v04B-3pfqA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 345
LYS A 368
MET A 388
TYR A 415
ARG A 459
LEU A 467
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
None
STU  A   1 (-4.7A)
None
STU  A   1 (-4.6A)
 1.17A 4v04B-3s95A:
26.0		 4v04B-3s95A:
30.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
LEU A 630
ILE A 544
LEU A 644
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
None
None
 1.38A 4v04B-3tt0A:
41.4		 4v04B-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
LYS A 514
MET A 535
ILE A 545
TYR A 563
LEU A 630
ILE A 639
LEU A 644
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
None
None
 0.58A 4v04B-3tt0A:
41.4		 4v04B-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
ARG A1027
LEU A1035
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
4TT  A2001 (-4.8A)
None
 0.34A 4v04B-3vidA:
35.3		 4v04B-3vidA:
49.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
VAL A 147
LYS A 162
TYR A 212
LEU A 263
ILE A 272
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 (-4.4A)
N13  A 501 (-4.5A)
None
 0.54A 4v04B-3w18A:
22.3		 4v04B-3w18A:
28.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
LYS A 868
ARG A1027
LEU A1035
ILE A1044
LEU A1049
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.8A)
None
LEV  A1201 ( 4.5A)
 1.28A 4v04B-3wzdA:
29.4		 4v04B-3wzdA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 LEU A 246
ILE A 302
TYR A 320
ARG A 363
LEU A 371
ILE A 380
 None
 1.03A 4v04B-4c0tA:
23.3		 4v04B-4c0tA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
VAL A 254
LYS A 269
ILE A 302
TYR A 320
LEU A 371
ILE A 380
 None
 0.64A 4v04B-4c0tA:
23.3		 4v04B-4c0tA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.96A 4v04B-4cfhA:
23.0		 4v04B-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ILE A  76
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
None
 1.17A 4v04B-4cfhA:
23.0		 4v04B-4cfhA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
LYS A 655
MET A 676
ILE A 685
TYR A 703
ARG A 765
LEU A 773
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 1.43A 4v04B-4ckrA:
31.4		 4v04B-4ckrA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
LYS A 655
MET A 676
ILE A 685
TYR A 703
LEU A 773
ILE A 782
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
 1.07A 4v04B-4ckrA:
31.4		 4v04B-4ckrA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.96A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.79A 4v04B-4crsA:
15.4		 4v04B-4crsA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
VAL A 523
LYS A 543
TYR A 590
LEU A 656
ILE A 665
 None
 0.87A 4v04B-4f0iA:
25.6		 4v04B-4f0iA:
38.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 377
VAL A 385
ARG A 493
LEU A 501
ILE A 510
LEU A 515
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
None
ANP  A 701 (-4.5A)
None
None
 0.86A 4v04B-4fl3A:
29.4		 4v04B-4fl3A:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 855
VAL A 863
LYS A 882
TYR A 931
ARG A 975
LEU A 983
ILE A 992
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 ( 4.7A)
None
 1.21A 4v04B-4gl9A:
27.8		 4v04B-4gl9A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
LYS A 855
TYR A 904
LEU A 956
ILE A 883
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
None
 0.98A 4v04B-4hviA:
29.8		 4v04B-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
LYS A 855
TYR A 904
LEU A 956
ILE A 965
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
None
 0.62A 4v04B-4hviA:
29.8		 4v04B-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 LEU A 132
VAL A 140
LYS A 158
ILE A 190
ARG A 251
LEU A 259
LEU A 273
 None
 1.33A 4v04B-4hzsA:
27.4		 4v04B-4hzsA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 LEU A 132
VAL A 140
LYS A 158
ILE A 190
LEU A 259
ILE A 268
LEU A 273
 None
 1.21A 4v04B-4hzsA:
27.4		 4v04B-4hzsA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
VAL A 140
LYS A 158
ILE A 190
LEU A 259
ILE A 268
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-4.6A)
None
 0.66A 4v04B-4id7A:
10.6		 4v04B-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
VAL A 486
LYS A 508
MET A 529
ILE A 539
TYR A 557
ARG A 616
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
None
None
None
None
 1.09A 4v04B-4k33A:
29.3		 4v04B-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 478
VAL A 486
MET A 529
ILE A 539
TYR A 557
ARG A 616
LEU A 624
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
None
None
None
None
ACP  A 801 (-4.4A)
None
 1.03A 4v04B-4k33A:
29.3		 4v04B-4k33A:
80.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
LYS A 930
ILE A 960
TYR A 980
ARG A1022
LEU A1030
ILE A1039
 2TT  A1202 (-3.5A)
None
None
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
None
 1.30A 4v04B-4oliA:
27.0		 4v04B-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A 959
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 1.21A 4v04B-4oliA:
27.0		 4v04B-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.75A 4v04B-4oliA:
27.0		 4v04B-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
LYS A 650
TYR A 703
ARG A 745
LEU A 753
 None
None
None
None
TPO  A 780 ( 2.8A)
None
 1.11A 4v04B-4otdA:
21.6		 4v04B-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 0.90A 4v04B-4otdA:
21.6		 4v04B-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 386
VAL A 394
LYS A 409
TYR A 460
LEU A 511
ILE A 520
 PZW  A 801 (-3.9A)
PZW  A 801 (-4.6A)
None
None
PZW  A 801 (-4.8A)
None
 0.92A 4v04B-4q9zA:
20.3		 4v04B-4q9zA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  24
VAL A  32
LYS A  47
ILE A  79
TYR A  97
ARG A 140
LEU A 148
ILE A 157
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
None
 1.00A 4v04B-4rewA:
22.5		 4v04B-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  24
VAL A  32
LYS A  47
ILE A  79
TYR A  97
ILE A  78
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
 1.08A 4v04B-4rewA:
22.5		 4v04B-4rewA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
 0.62A 4v04B-4rt7A:
29.0		 4v04B-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
LYS A  37
MET A  56
TYR A  83
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.88A 4v04B-4ueuA:
30.7		 4v04B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
LYS A  37
TYR A  83
ARG A 128
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.8A)
 1.06A 4v04B-4ueuA:
30.7		 4v04B-4ueuA:
41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
VAL A 112
LYS A 127
TYR A 177
ARG A 220
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
TPO  A 252 ( 2.9A)
ATP  A 501 (-4.5A)
 0.96A 4v04B-4wb7A:
20.6		 4v04B-4wb7A:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
MET A 524
ILE A 534
LEU A 619
ILE A 628
LEU A 633
 40M  A1002 ( 4.6A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
None
None
 0.51A 4v04B-4xcuA:
38.7		 4v04B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 473
VAL A 481
LYS A 503
MET A 524
ILE A 534
LEU A 619
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
None
 0.62A 4v04B-4xcuA:
38.7		 4v04B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.51A 4v04B-4xufA:
33.5		 4v04B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
LYS A 644
MET A 665
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.74A 4v04B-4xufA:
33.5		 4v04B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ILE A 545
TYR A 563
LEU A 630
ILE A 544
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
None
None
 1.41A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
LYS A 514
MET A 535
TYR A 563
ARG A 622
ILE A 639
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
None
None
None
 0.66A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
LYS A 514
TYR A 563
ILE A 544
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
38O  A1769 (-4.2A)
None
None
 1.17A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
VAL A 492
MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
LEU A 644
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
None
None
 0.32A 4v04B-5a46A:
43.3		 4v04B-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.63A 4v04B-5f1zA:
28.2		 4v04B-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
LYS A 930
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.57A 4v04B-5f1zA:
28.2		 4v04B-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 730
VAL A 738
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
None
SEP  A 909 ( 3.0A)
PP1  A2012 (-4.6A)
None
 1.17A 4v04B-5fm2A:
34.0		 4v04B-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
VAL A 607
LYS A 627
MET A 648
TYR A 676
ARG A 817
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
 0.97A 4v04B-5grnA:
26.2		 4v04B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
VAL A 607
LYS A 627
MET A 648
TYR A 676
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.66A 4v04B-5grnA:
26.2		 4v04B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  30
LYS A  45
ILE A  66
TYR A  84
ARG A 132
ILE A 149
 032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-4.2A)
None
None
 0.72A 4v04B-5hesA:
20.4		 4v04B-5hesA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
VAL A  65
LYS A  79
MET A  99
TYR A 132
ARG A 179
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
None
IDV  A 401 (-4.4A)
 1.31A 4v04B-5i3oA:
21.9		 4v04B-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  35
ILE A  79
TYR A  99
ARG A 150
LEU A 158
ILE A 171
 6A7  A 401 ( 4.5A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
None
6A7  A 401 (-4.8A)
None
 0.93A 4v04B-5idnA:
15.6		 4v04B-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		8 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
None
 1.22A 4v04B-5isoA:
22.6		 4v04B-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 284
LYS A 299
MET A 319
TYR A 346
ARG A 388
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
None
IPW  A 601 (-4.5A)
 1.15A 4v04B-5kbrA:
22.0		 4v04B-5kbrA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
VAL A 899
LYS A 919
TYR A 965
LEU A1017
ILE A1026
LEU A1031
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
None
None
 1.38A 4v04B-5wnoA:
27.9		 4v04B-5wnoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 6 LEU A  22
VAL A  30
ILE A  77
TYR A  95
LEU A 146
ILE A 155
 EDJ  A 301 (-3.9A)
None
EDJ  A 301 ( 4.7A)
EDJ  A 301 ( 4.8A)
EDJ  A 301 ( 4.5A)
None
 0.73A 4v04B-6bx6A:
19.4		 4v04B-6bx6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
LYS A  89
MET A 111
TYR A 138
ARG A 181
LEU A 189
ILE A 198
 None
 0.97A 4v04B-6c9dA:
21.9		 4v04B-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 VAL A 200
LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 1.03A 4v04B-6f3dA:
23.3		 4v04B-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 LEU A 730
VAL A 738
ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
FMT  A1101 (-2.8A)
ADN  A1104 (-4.3A)
None
 1.17A 4v04B-6fekA:
33.3		 4v04B-6fekA:
18.64