SIMILAR PATTERNS OF AMINO ACIDS FOR 4V04_A_0LIA1772_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		4 ILE A 335
TYR A 293
ILE A 304
PHE A 376
 None
 0.87A 4v04A-1edgA:
undetectable		 4v04A-1edgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
MET A 240
TYR A 268
LEU A 321
 None
 0.68A 4v04A-1k9aA:
25.0		 4v04A-1k9aA:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 MET A 240
TYR A 268
ARG A 313
LEU A 321
 None
 0.75A 4v04A-1k9aA:
25.0		 4v04A-1k9aA:
29.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 LYS A 608
TYR A 656
ARG A 723
LEU A 731
ILE A 740
 None
 1.31A 4v04A-1lufA:
33.6		 4v04A-1lufA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LYS A  57
ILE A  89
TYR A 107
LEU A 158
 None
 0.52A 4v04A-1u5qA:
23.6		 4v04A-1u5qA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 ARG A  22
LEU A 133
ILE A   7
PHE A 148
 MTX  A 187 (-3.3A)
None
MTX  A 187 (-3.8A)
None
 0.84A 4v04A-1u70A:
undetectable		 4v04A-1u70A:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS X  39
MET X  58
TYR X  84
LEU X 137
 STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
 0.55A 4v04A-2dq7X:
30.1		 4v04A-2dq7X:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET X  58
TYR X  84
ARG X 129
LEU X 137
ILE X 146
 None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
None
 1.20A 4v04A-2dq7X:
30.1		 4v04A-2dq7X:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		4 LYS A 200
ILE A 130
ILE A 129
PHE A 181
 None
 0.86A 4v04A-2ehhA:
undetectable		 4v04A-2ehhA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LYS A  57
ILE A  89
TYR A 107
LEU A 158
 STU  A 400 ( 4.5A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
 0.55A 4v04A-2gcdA:
24.2		 4v04A-2gcdA:
26.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 273
MET A 292
ARG A 363
LEU A 371
ILE A 380
 1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-4.4A)
None
 1.34A 4v04A-2hk5A:
24.4		 4v04A-2hk5A:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 ILE A  70
TYR A  64
LEU A  36
ILE A  10
 None
 0.80A 4v04A-2jfwA:
undetectable		 4v04A-2jfwA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
LEU A 371
ILE A 380
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 4.3A)
 0.88A 4v04A-2og8A:
30.8		 4v04A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 292
LEU A 371
ILE A 380
PHE A 383
 1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 4.3A)
 0.58A 4v04A-2og8A:
30.8		 4v04A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 637
TYR A 665
ARG A 777
LEU A 785
ILE A 794
 None
 1.10A 4v04A-2ogvA:
33.1		 4v04A-2ogvA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 886
LEU A 971
ILE A 980
PHE A 983
 MR9  A 301 (-4.0A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.6A)
MR9  A 301 (-4.4A)
 0.70A 4v04A-2p4iA:
25.4		 4v04A-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 904
LEU A 971
ILE A 980
PHE A 983
 MR9  A 301 (-3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.6A)
MR9  A 301 (-4.4A)
 0.77A 4v04A-2p4iA:
25.4		 4v04A-2p4iA:
42.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF04998
(RNA_pol_Rpb1_5) 		4 ILE C 250
ARG C 239
LEU C 126
ILE C 124
 None
 0.79A 4v04A-2pmzC:
undetectable		 4v04A-2pmzC:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
SO4  A 303 ( 2.9A)
None
None
 1.15A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 538
ILE A 548
TYR A 566
LEU A 633
ILE A 642
 None
 0.46A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS C  78
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 (-3.6A)
None
None
None
 0.73A 4v04A-2wtkC:
15.6		 4v04A-2wtkC:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 517
MET A 538
ILE A 548
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.5A)
None
None
None
M33  A1996 (-4.5A)
None
 1.32A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 538
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
M33  A1996 ( 4.7A)
None
M33  A1996 (-4.5A)
None
 1.30A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 514
ILE A 545
TYR A 563
ARG A 622
LEU A 630
 None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.61A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
None
 0.37A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 535
ILE A 545
TYR A 563
LEU A 630
ILE A 639
PHE A 489
 C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
None
C4F  A   1 (-3.7A)
 0.74A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
MET A 240
TYR A 268
LEU A 321
 None
 0.68A 4v04A-3d7uA:
25.0		 4v04A-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 240
TYR A 268
ARG A 313
LEU A 321
 None
 0.75A 4v04A-3d7uA:
25.0		 4v04A-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 204
ARG A 267
LEU A 275
ILE A 292
 VIN  A6331 ( 4.9A)
None
VIN  A6331 (-4.5A)
None
 0.75A 4v04A-3dtcA:
26.6		 4v04A-3dtcA:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  38
MET A  54
ILE A  63
LEU A 173
 None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
 0.67A 4v04A-3eb0A:
20.4		 4v04A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  38
MET A  54
ILE A  63
TYR A 119
 None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
 0.70A 4v04A-3eb0A:
20.4		 4v04A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		4 ILE A  75
TYR A  93
LEU A 143
ILE A 157
 None
 0.65A 4v04A-3gbzA:
21.8		 4v04A-3gbzA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE

(Pseudomonas
savastanoi) 		PF13561
(adh_short_C2) 		4 ILE A  33
LEU A   9
ILE A  34
PHE A  67
 None
 0.88A 4v04A-3gemA:
undetectable		 4v04A-3gemA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 4 ILE B  95
TYR B 113
LEU B 163
ILE B 172
 None
 0.58A 4v04A-3h4jB:
16.0		 4v04A-3h4jB:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 4 LYS B  63
ILE B  95
TYR B 113
ILE B 172
 None
 0.49A 4v04A-3h4jB:
16.0		 4v04A-3h4jB:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdt PUTATIVE KINASE

([Clostridium]
symbiosum) 		PF13189
(Cytidylate_kin2) 		4 ILE A  13
ARG A  25
LEU A 135
ILE A  14
 None
 0.88A 4v04A-3hdtA:
undetectable		 4v04A-3hdtA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 911
ARG A1021
LEU A1029
ILE A1038
 8ST  A2001 (-4.9A)
None
None
None
 0.66A 4v04A-3hngA:
34.2		 4v04A-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2d E3 SUMO-PROTEIN
LIGASE SIZ1

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 ARG A 367
LEU A 412
ILE A 414
PHE A 383
 None
 0.87A 4v04A-3i2dA:
undetectable		 4v04A-3i2dA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LYS A  82
TYR A 131
LEU A 182
ILE A 191
 None
 0.50A 4v04A-3iecA:
22.3		 4v04A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 MET A 104
TYR A 131
ARG A 174
LEU A 182
ILE A 191
 None
 0.90A 4v04A-3iecA:
22.3		 4v04A-3iecA:
27.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 MET A 688
ILE A 697
TYR A 715
ARG A 759
LEU A 767
 None
None
GOL  A 403 (-4.1A)
None
None
 1.48A 4v04A-3kulA:
32.1		 4v04A-3kulA:
34.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  62
ILE A  94
TYR A 112
ILE A 177
 QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
 0.75A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  62
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.71A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 116
TYR A 134
LEU A 184
ILE A 193
 None
 0.60A 4v04A-3mn3A:
20.4		 4v04A-3mn3A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 134
TYR A 161
ARG A 204
LEU A 212
ILE A 221
 None
None
SEP  A 241 ( 3.4A)
None
None
 1.10A 4v04A-3nuuA:
22.9		 4v04A-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 ILE A 214
ARG A 196
LEU A 190
ILE A 206
 None
EDO  A 404 ( 4.0A)
None
None
 0.80A 4v04A-3op7A:
undetectable		 4v04A-3op7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ova CCA-ADDING ENZYME

(Archaeoglobus
fulgidus) 		PF01909
(NTP_transf_2)
PF09249
(tRNA_NucTransf2) 		4 TYR A 392
LEU A 308
ILE A 335
PHE A 279
 A  C  22 ( 4.5A)
None
None
None
 0.83A 4v04A-3ovaA:
undetectable		 4v04A-3ovaA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
MET A 600
TYR A 627
LEU A 683
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.53A 4v04A-3ppzA:
27.8		 4v04A-3ppzA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 368
MET A 388
TYR A 415
ARG A 459
LEU A 467
 STU  A   1 (-3.1A)
None
STU  A   1 (-4.7A)
None
STU  A   1 (-4.6A)
 1.24A 4v04A-3s95A:
25.4		 4v04A-3s95A:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		4 ILE A 271
TYR A 205
LEU A 273
PHE A 256
 None
None
EDO  A 347 ( 4.3A)
None
 0.81A 4v04A-3tlzA:
undetectable		 4v04A-3tlzA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 514
MET A 535
ILE A 545
TYR A 563
LEU A 630
ILE A 639
 07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
None
 0.39A 4v04A-3tt0A:
41.1		 4v04A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 868
ARG A1027
LEU A1035
ILE A1044
 None
None
4TT  A2001 (-4.8A)
None
 0.50A 4v04A-3vidA:
34.7		 4v04A-3vidA:
49.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 162
TYR A 212
LEU A 263
ILE A 272
 N13  A 501 (-2.9A)
N13  A 501 (-4.4A)
N13  A 501 (-4.5A)
None
 0.58A 4v04A-3w18A:
21.9		 4v04A-3w18A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.96A 4v04A-4cfhA:
22.7		 4v04A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
 1.08A 4v04A-4cfhA:
22.7		 4v04A-4cfhA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 655
ILE A 685
LEU A 773
ILE A 782
PHE A 785
 DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
 0.79A 4v04A-4ckrA:
30.6		 4v04A-4ckrA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 655
ILE A 685
TYR A 703
LEU A 773
ILE A 782
 DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
 0.96A 4v04A-4ckrA:
30.6		 4v04A-4ckrA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 543
ARG A 648
LEU A 656
ILE A 665
 None
 0.77A 4v04A-4f0iA:
25.8		 4v04A-4f0iA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 882
TYR A 931
LEU A 983
ILE A 992
 IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.7A)
None
 0.80A 4v04A-4gl9A:
27.5		 4v04A-4gl9A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 855
TYR A 904
LEU A 956
ILE A 965
 19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
None
 0.79A 4v04A-4hviA:
29.2		 4v04A-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		4 LYS A 158
ILE A 190
LEU A 259
ILE A 268
 None
 0.71A 4v04A-4hzsA:
27.3		 4v04A-4hzsA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 508
MET A 529
ILE A 539
TYR A 557
 ACP  A 801 (-2.7A)
None
None
None
 0.54A 4v04A-4k33A:
29.3		 4v04A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 529
ILE A 539
TYR A 557
ARG A 616
LEU A 624
ILE A 633
 None
None
None
None
ACP  A 801 (-4.4A)
None
 1.20A 4v04A-4k33A:
29.3		 4v04A-4k33A:
80.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvt E3 SUMO-PROTEIN
LIGASE PIAS3

(Homo sapiens) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 ARG A 333
LEU A 378
ILE A 380
PHE A 349
 None
 0.80A 4v04A-4mvtA:
undetectable		 4v04A-4mvtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 960
TYR A 980
ARG A1022
LEU A1030
ILE A1039
 None
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
None
 1.46A 4v04A-4oliA:
26.9		 4v04A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.72A 4v04A-4oliA:
26.9		 4v04A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 ILE A  70
TYR A  54
LEU A  72
ILE A 208
 None
 0.88A 4v04A-4qhbA:
undetectable		 4v04A-4qhbA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ILE A  79
TYR A  97
ARG A 140
LEU A 148
ILE A 157
 STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
None
 1.13A 4v04A-4rewA:
22.2		 4v04A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LYS A  47
ILE A  79
TYR A  97
LEU A 148
 STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.48A 4v04A-4rewA:
22.2		 4v04A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 ILE A 213
ARG A 191
LEU A 151
ILE A 212
 None
 0.75A 4v04A-4rxmA:
undetectable		 4v04A-4rxmA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LYS A  37
MET A  56
TYR A  83
LEU A 136
 None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.73A 4v04A-4ueuA:
30.3		 4v04A-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 204
ARG A 267
LEU A 275
ILE A 292
 None
 0.67A 4v04A-4uy9A:
26.7		 4v04A-4uy9A:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 184
ARG A 262
LEU A 270
ILE A 287
 AGS  A1438 (-4.2A)
None
AGS  A1438 (-4.7A)
None
 0.67A 4v04A-4uyaA:
26.0		 4v04A-4uyaA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 503
MET A 524
ILE A 534
LEU A 619
ILE A 628
 40M  A1002 (-4.0A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
None
 0.50A 4v04A-4xcuA:
38.9		 4v04A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 644
MET A 665
TYR A 693
LEU A 818
 P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.79A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.53A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 644
TYR A 693
LEU A 818
PHE A 830
 P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 ( 4.1A)
 0.71A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 490
ILE A 522
TYR A 541
LEU A 595
 4CV  A 801 (-3.9A)
4CV  A 801 ( 4.2A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
 0.69A 4v04A-4yffA:
24.5		 4v04A-4yffA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 514
MET A 535
TYR A 563
ARG A 622
 38O  A1769 ( 3.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
None
 0.85A 4v04A-5a46A:
43.5		 4v04A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
None
 0.23A 4v04A-5a46A:
43.5		 4v04A-5a46A:
98.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.88A 4v04A-5ci7A:
18.6		 4v04A-5ci7A:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.75A 4v04A-5f1zA:
22.9		 4v04A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 None
None
SEP  A 909 ( 3.0A)
PP1  A2012 (-4.6A)
None
 1.33A 4v04A-5fm2A:
33.7		 4v04A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 627
MET A 648
TYR A 676
LEU A 825
 748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.68A 4v04A-5grnA:
25.8		 4v04A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 648
TYR A 676
LEU A 825
ILE A 834
 748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.49A 4v04A-5grnA:
25.8		 4v04A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A  66
TYR A  84
ARG A 132
ILE A 149
 032  A 401 (-4.4A)
032  A 401 (-4.2A)
None
None
 0.80A 4v04A-5hesA:
25.7		 4v04A-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A  45
ILE A  66
ARG A 132
ILE A 149
 032  A 401 (-4.4A)
032  A 401 (-4.4A)
None
None
 0.76A 4v04A-5hesA:
25.7		 4v04A-5hesA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  79
MET A  99
TYR A 132
LEU A 187
 IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.70A 4v04A-5i3oA:
21.6		 4v04A-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  79
TYR A  99
LEU A 158
ILE A 171
 6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
None
 0.81A 4v04A-5idnA:
15.5		 4v04A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
None
 1.09A 4v04A-5isoA:
22.4		 4v04A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LYS A  45
ILE A  77
TYR A  95
LEU A 146
 STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.73A 4v04A-5isoA:
22.4		 4v04A-5isoA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 665
ILE A 695
ARG A 757
LEU A 765
 None
None
None
6P6  A1001 (-4.5A)
 0.81A 4v04A-5l6oA:
31.5		 4v04A-5l6oA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 174
ARG A 235
LEU A 243
ILE A 252
 None
None
9FS  A 501 (-4.7A)
None
 0.84A 4v04A-5vo1A:
25.7		 4v04A-5vo1A:
35.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 TYR A 143
ARG A 198
LEU A 206
ILE A 215
 ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
None
 0.70A 4v04A-5xd6A:
21.6		 4v04A-5xd6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 4 ILE A 433
ARG A 474
LEU A 381
PHE A 461
 None
 0.76A 4v04A-5yxgA:
undetectable		 4v04A-5yxgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 4 ILE A 433
ARG A 474
LEU A 381
PHE A 461
 None
 0.88A 4v04A-5z24A:
undetectable		 4v04A-5z24A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 LYS A  89
TYR A 138
LEU A 189
ILE A 198
 None
 0.76A 4v04A-6c9dA:
21.2		 4v04A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 MET A 111
TYR A 138
ARG A 181
LEU A 189
ILE A 198
 None
 1.02A 4v04A-6c9dA:
21.2		 4v04A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 5 LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 1.05A 4v04A-6f3dA:
23.0		 4v04A-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 5 ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
FMT  A1101 (-2.8A)
ADN  A1104 (-4.3A)
None
 1.37A 4v04A-6fekA:
32.7		 4v04A-6fekA:
18.64