SIMILAR PATTERNS OF AMINO ACIDS FOR 4V04_A_0LIA1772

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
GLU A  51
CYH A 117
HIS A 124
ALA A 143
 None
 1.26A 4v04A-1h4lA:
17.9		 4v04A-1h4lA:
27.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 588
ALA A 606
LEU A 715
HIS A 722
ALA A 741
ASP A 742
 None
 0.80A 4v04A-1lufA:
33.6		 4v04A-1lufA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 275
ALA A 288
GLU A 305
HIS A 380
ALA A 399
GLY A 402
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.5A)
None
 1.08A 4v04A-1opkA:
29.6		 4v04A-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 275
ALA A 288
GLU A 305
LEU A 373
HIS A 380
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
None
P16  A   2 (-3.5A)
 0.63A 4v04A-1opkA:
29.6		 4v04A-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 219
ALA A 230
GLU A 245
HIS A 331
ALA A 350
GLY A 353
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 ( 4.2A)
None
 0.91A 4v04A-1py5A:
20.7		 4v04A-1py5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 VAL A 219
ALA A 230
GLU A 245
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.63A 4v04A-1py5A:
20.7		 4v04A-1py5A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A 172
ALA A 185
GLU A 202
HIS A 292
ALA A 549
GLY A 552
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
None
None
None
None
 1.35A 4v04A-1q8yA:
20.2		 4v04A-1q8yA:
24.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
MET A 664
LEU A 802
CYH A 807
 None
 1.07A 4v04A-1rjbA:
32.8		 4v04A-1rjbA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
 None
 0.90A 4v04A-1rjbA:
32.8		 4v04A-1rjbA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 603
ALA A 621
GLU A 640
LEU A 783
CYH A 788
HIS A 790
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
 0.68A 4v04A-1t46A:
34.3		 4v04A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 352
ALA A 367
GLU A 386
ALA A 417
LEU A 452
HIS A 459
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
None
STU  A 100 (-3.7A)
None
None
 0.73A 4v04A-1u59A:
30.2		 4v04A-1u59A:
35.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  98
ALA A 111
MET A 132
LEU A 196
HIS A 203
ASP A 226
 None
 1.00A 4v04A-2ac5A:
19.0		 4v04A-2ac5A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  98
GLU A 129
MET A 132
LEU A 196
HIS A 203
ASP A 226
 None
 1.25A 4v04A-2ac5A:
19.0		 4v04A-2ac5A:
26.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 170
ALA A 184
GLU A 201
HIS A 281
ALA A 319
GLY A 322
 None
 1.32A 4v04A-2eu9A:
21.2		 4v04A-2eu9A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 170
ALA A 184
GLU A 201
LEU A 274
HIS A 281
ALA A 319
 None
 0.88A 4v04A-2eu9A:
21.2		 4v04A-2eu9A:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 259
ALA A 271
GLU A 288
HIS A 362
ALA A 381
GLY A 384
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.7A)
None
 1.33A 4v04A-2hk5A:
24.4		 4v04A-2hk5A:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 269
GLU A 286
LEU A 354
HIS A 361
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 1.01A 4v04A-2hz0A:
29.6		 4v04A-2hz0A:
40.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  18
ALA A  31
GLU A  51
CYH A 118
HIS A 125
ALA A 144
 None
 1.11A 4v04A-2jgzA:
22.6		 4v04A-2jgzA:
25.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 259
ALA A 271
GLU A 288
HIS A 362
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.65A 4v04A-2og8A:
30.8		 4v04A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 596
ALA A 614
GLU A 633
LEU A 769
CYH A 774
HIS A 776
 None
 0.60A 4v04A-2ogvA:
33.1		 4v04A-2ogvA:
47.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 VAL A 352
ALA A 367
ALA A 417
LEU A 452
HIS A 459
GLY A 481
 ANP  A 615 (-4.5A)
ANP  A 615 (-3.3A)
ANP  A 615 (-3.9A)
None
None
None
 0.74A 4v04A-2ozoA:
27.8		 4v04A-2ozoA:
21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 838
ALA A 853
ALA A 905
LEU A 955
HIS A 962
ALA A 981
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 (-3.6A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.55A 4v04A-2p4iA:
25.4		 4v04A-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 495
ALA A 515
GLU A 534
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 None
 0.65A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
GLU A 534
VAL A 564
ALA A 567
HIS A 624
ALA A 643
GLY A 646
 None
 1.20A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 204
ALA A 215
GLU A 230
LEU A 301
HIS A 319
ALA A 338
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
None
None
 0.95A 4v04A-2qluA:
24.2		 4v04A-2qluA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ALA A 218
GLU A 230
VAL A 285
ALA A 220
LEU A 189
ASP A 226
 None
 1.19A 4v04A-2vk4A:
undetectable		 4v04A-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.63A 4v04A-2xikA:
18.5		 4v04A-2xikA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
GLU A 290
HIS A 365
ALA A 384
ASP A 385
GLY A 387
 None
 1.41A 4v04A-2zv7A:
30.7		 4v04A-2zv7A:
38.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
GLU A 534
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
 0.91A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
GLU A 534
VAL A 564
ALA A 567
HIS A 624
GLY A 646
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
 1.43A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
GLU A 534
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
 0.78A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
 0.77A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
VAL A 564
ALA A 567
HIS A 624
ALA A 643
GLY A 646
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
None
 1.13A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
None
M33  A1996 (-3.8A)
None
None
None
None
 0.52A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  28
ALA A  41
GLU A  61
CYH A 127
HIS A 134
ALA A 156
 5CP  A 600 ( 4.4A)
5CP  A 600 (-3.6A)
None
None
None
5CP  A 600 ( 3.9A)
 1.27A 4v04A-3bhhA:
22.6		 4v04A-3bhhA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1108
GLU A1127
LEU A1195
HIS A1202
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.85A 4v04A-3c1xA:
25.9		 4v04A-3c1xA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 492
ALA A 512
GLU A 531
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
None
 0.55A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dak SERINE/THREONINE-PRO
TEIN KINASE OSR1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  31
ALA A  44
LEU A 137
HIS A 144
ALA A 163
GLY A 166
 ANP  A   1 (-4.5A)
ANP  A   1 ( 3.9A)
None
None
MG  A 296 ( 3.9A)
None
 0.71A 4v04A-3dakA:
21.3		 4v04A-3dakA:
30.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  40
ALA A  53
GLU A  73
LEU A 142
HIS A 149
ASP A 169
 35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
None
None
None
None
 0.98A 4v04A-3e7oA:
19.6		 4v04A-3e7oA:
25.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 841
ALA A 859
GLU A 878
VAL A 909
LEU A1013
CYH A1018
HIS A1020
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 0.60A 4v04A-3hngA:
34.2		 4v04A-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		6 VAL A  56
ALA A  12
VAL A 131
ALA A  10
ALA A 147
ASP A 146
 None
 1.22A 4v04A-3hu5A:
undetectable		 4v04A-3hu5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
ALA A 132
HIS A 173
ALA A 192
ASP A 193
GLY A 195
 None
 1.35A 4v04A-3iecA:
22.3		 4v04A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  47
ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.86A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
GLU A 244
HIS A 330
ALA A 349
GLY A 352
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 ( 3.8A)
None
 1.30A 4v04A-3mdyA:
24.8		 4v04A-3mdyA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
ALA A 229
GLU A 244
LEU A 315
HIS A 330
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.90A 4v04A-3mdyA:
24.8		 4v04A-3mdyA:
26.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 216
ALA A 227
HIS A 328
ALA A 347
ASP A 348
GLY A 350
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
LDN  A 600 ( 3.8A)
None
None
 0.93A 4v04A-3my0A:
24.1		 4v04A-3my0A:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 216
ALA A 227
LEU A 313
HIS A 328
ALA A 347
ASP A 348
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
None
None
LDN  A 600 ( 3.8A)
None
 1.12A 4v04A-3my0A:
24.1		 4v04A-3my0A:
30.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
ALA A 162
HIS A 203
ASP A 223
GLY A 225
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
JOZ  A 361 (-3.8A)
None
SO4  A   5 ( 4.5A)
SO4  A   5 ( 4.6A)
 1.35A 4v04A-3nuuA:
22.9		 4v04A-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  96
ALA A 109
GLU A 130
ALA A 162
HIS A 203
GLY A 225
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
JOZ  A 361 (-3.8A)
None
SO4  A   5 ( 4.6A)
 1.17A 4v04A-3nuuA:
22.9		 4v04A-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  96
ALA A 109
GLU A 130
ALA A 162
LEU A 196
HIS A 203
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
JOZ  A 361 (-3.8A)
None
None
 0.71A 4v04A-3nuuA:
22.9		 4v04A-3nuuA:
26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pls MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1096
ALA A1112
LEU A1199
HIS A1206
ALA A1225
GLY A1228
 ANP  A1358 (-4.4A)
ANP  A1358 ( 3.8A)
None
None
None
None
 0.72A 4v04A-3plsA:
30.2		 4v04A-3plsA:
39.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 206
ALA A 217
GLU A 232
LEU A 303
HIS A 320
ALA A 339
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 ( 4.9A)
None
None
TAK  A   2 ( 4.2A)
 1.01A 4v04A-3q4tA:
23.6		 4v04A-3q4tA:
26.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 492
ALA A 512
GLU A 531
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
None
None
None
07J  A   1 (-3.2A)
None
 0.56A 4v04A-3tt0A:
41.1		 4v04A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
None
 0.75A 4v04A-3vidA:
34.7		 4v04A-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
None
 0.47A 4v04A-3vidA:
34.7		 4v04A-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
HIS A1026
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
None
 0.47A 4v04A-3wzdA:
34.6		 4v04A-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
 None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 0.82A 4v04A-4agdA:
34.6		 4v04A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 None
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
None
 0.71A 4v04A-4agdA:
34.6		 4v04A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 653
GLU A 672
LEU A 757
HIS A 764
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.66A 4v04A-4ckrA:
30.6		 4v04A-4ckrA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 671
ALA A 684
GLU A 705
ALA A 740
ALA A 799
GLY A 802
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
AGS  A1985 ( 4.5A)
None
 1.29A 4v04A-4crsA:
15.0		 4v04A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 VAL A 671
ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v04A-4crsA:
15.0		 4v04A-4crsA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 VAL A 575
ALA A 588
GLU A 607
LEU A 674
CYH A 679
HIS A 681
 GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
None
None
None
None
 1.01A 4v04A-4e93A:
32.1		 4v04A-4e93A:
33.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 385
ALA A 400
GLU A 420
ALA A 451
HIS A 492
GLY A 514
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
None
0SB  A 701 (-4.0A)
None
None
 1.32A 4v04A-4f4pA:
25.9		 4v04A-4f4pA:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 VAL A 385
ALA A 400
ALA A 451
LEU A 485
HIS A 492
GLY A 514
 ANP  A 701 (-4.1A)
ANP  A 701 (-3.3A)
ANP  A 701 (-4.1A)
None
None
None
 0.88A 4v04A-4fl3A:
29.1		 4v04A-4fl3A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  37
ALA A  50
GLU A  71
VAL A 100
LEU A 137
HIS A 144
 STU  A 401 ( 4.9A)
STU  A 401 (-3.2A)
None
None
None
None
 0.79A 4v04A-4fr4A:
13.2		 4v04A-4fr4A:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 836
ALA A 853
GLU A 871
LEU A 940
CYH A 945
HIS A 947
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
None
None
None
None
19S  A1201 ( 4.1A)
 0.73A 4v04A-4hviA:
29.2		 4v04A-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
VAL A 555
ALA A 558
HIS A 615
ALA A 634
ASP A 635
GLY A 637
 ACP  A 801 (-3.3A)
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
MG  A 802 ( 3.0A)
None
 1.36A 4v04A-4k33A:
29.3		 4v04A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 486
ALA A 506
GLU A 525
MET A 528
VAL A 555
ALA A 558
LEU A 608
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
 0.82A 4v04A-4k33A:
29.3		 4v04A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 486
ALA A 506
GLU A 525
VAL A 555
ALA A 558
HIS A 615
ALA A 634
GLY A 637
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
None
 1.26A 4v04A-4k33A:
29.3		 4v04A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 486
ALA A 506
GLU A 525
VAL A 555
ALA A 558
LEU A 608
HIS A 615
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
None
 0.70A 4v04A-4k33A:
29.3		 4v04A-4k33A:
80.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
GLU B  70
HIS B 142
ALA B 161
GLY B 164
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
None
 1.24A 4v04A-4o27B:
24.2		 4v04A-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
GLU B  70
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
None
None
 0.60A 4v04A-4o27B:
24.2		 4v04A-4o27B:
28.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 624
ALA A 642
GLU A 661
MET A 664
LEU A 802
CYH A 807
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
None
 0.96A 4v04A-4rt7A:
28.4		 4v04A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
P30  A1001 ( 4.3A)
None
 0.84A 4v04A-4rt7A:
28.4		 4v04A-4rt7A:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr2 SUBTILISIN-LIKE 1
SERINE PROTEASE

(Plasmodium
vivax) 		PF00082
(Peptidase_S8) 		6 ALA A 293
ALA A 528
LEU A 399
ALA A 557
ASP A 394
GLY A 395
 None
 1.26A 4v04A-4tr2A:
undetectable		 4v04A-4tr2A:
19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
GLU A  52
HIS A 127
ALA A 146
ASP A 147
GLY A 149
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
None
 1.36A 4v04A-4ueuA:
30.3		 4v04A-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 158
ALA A 169
ALA A 223
LEU A 256
HIS A 266
GLY A 296
 None
 0.72A 4v04A-4uy9A:
26.7		 4v04A-4uy9A:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 481
ALA A 501
GLU A 520
VAL A 550
ALA A 553
LEU A 603
CYH A 608
HIS A 610
ALA A 629
GLY A 632
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
None
40M  A1002 (-3.0A)
None
 0.38A 4v04A-4xcuA:
38.9		 4v04A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
None
P30  A1001 (-4.4A)
None
 0.69A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 477
ALA A 488
GLU A 509
LEU A 577
HIS A 586
ALA A 605
 None
4CV  A 801 (-3.5A)
None
None
None
4CV  A 801 ( 3.9A)
 0.94A 4v04A-4yffA:
24.6		 4v04A-4yffA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 VAL A 492
ALA A 512
GLU A 531
MET A 534
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
GLY A 643
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
None
EDO  A1766 ( 4.4A)
EDO  A1766 (-3.6A)
 0.23A 4v04A-5a46A:
43.5		 4v04A-5a46A:
98.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbx STE20/SPS1-RELATED
PROLINE-ALANINE-RICH
PROTEIN KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL A  89
ALA A 102
LEU A 195
HIS A 202
ALA A 221
GLY A 224
 ANP  A 401 (-4.0A)
ANP  A 401 ( 4.0A)
None
None
MG  A 402 ( 4.6A)
None
 0.89A 4v04A-5dbxA:
20.7		 4v04A-5dbxA:
28.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
ALA A  83
GLU A 103
ALA A 135
HIS A 176
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
5RC  A4000 ( 3.9A)
 0.79A 4v04A-5es1A:
22.4		 4v04A-5es1A:
28.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 738
ALA A 756
GLU A 775
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-3.5A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
None
 0.90A 4v04A-5fm2A:
33.7		 4v04A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 607
ALA A 625
GLU A 644
LEU A 809
CYH A 814
HIS A 816
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.62A 4v04A-5grnA:
25.8		 4v04A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  30
ALA A  43
ALA A  85
LEU A 121
HIS A 131
GLY A 153
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-3.6A)
None
None
032  A 401 (-3.6A)
 0.68A 4v04A-5hesA:
25.7		 4v04A-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1092
ALA A1108
LEU A1195
HIS A1202
ALA A1221
GLY A1224
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.3A)
None
 0.83A 4v04A-5horA:
26.0		 4v04A-5horA:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 VAL A  28
ALA A  41
GLU A  61
HIS A 134
ALA A 156
GLY A 159
 ADP  A 301 (-3.7A)
ADP  A 301 (-3.5A)
None
None
ADP  A 301 ( 4.8A)
None
 1.30A 4v04A-5hu3A:
22.7		 4v04A-5hu3A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  50
GLU A  66
ALA A 100
HIS A 149
ALA A 172
GLY A 175
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-3.7A)
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
FMT  A 404 ( 4.3A)
 1.41A 4v04A-5idnA:
15.5		 4v04A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  50
GLU A  66
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.81A 4v04A-5idnA:
15.5		 4v04A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
GLU A  61
LEU A 127
HIS A 134
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 ( 4.2A)
 0.75A 4v04A-5j5tA:
21.0		 4v04A-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
ALA A  43
GLU A  61
MET A  64
HIS A 134
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 ( 4.2A)
 0.99A 4v04A-5j5tA:
21.0		 4v04A-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE

(Pseudomonas
putida) 		PF01053
(Cys_Met_Meta_PP) 		6 VAL A 185
ALA A 160
LEU A 143
ALA A 167
ASP A 168
GLY A 171
 None
 1.25A 4v04A-5x2vA:
undetectable		 4v04A-5x2vA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 VAL A  94
ALA A 107
GLU A 124
HIS A 211
ALA A 496
GLY A 499
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
EMH  A 705 ( 4.0A)
None
 1.33A 4v04A-5xv7A:
20.3		 4v04A-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 6 VAL A  94
ALA A 107
GLU A 124
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 ( 4.4A)
EMH  A 705 (-3.6A)
None
None
None
EMH  A 705 ( 4.0A)
 0.65A 4v04A-5xv7A:
20.3		 4v04A-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 VAL A  41
ALA A  54
LEU A 137
HIS A 144
ALA A 163
GLY A 166
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
None
None
None
None
 0.89A 4v04A-6ao5A:
22.0		 4v04A-6ao5A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 VAL A 741
ALA A 754
GLU A 774
CYH A 850
HIS A 857
ALA A 876
 None
CJM  A1102 (-3.1A)
None
None
None
CJM  A1102 (-3.6A)
 1.17A 4v04A-6b3eA:
22.1		 4v04A-6b3eA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
ALA A  87
GLU A 107
ALA A 139
HIS A 180
ALA A 199
GLY A 202
 None
 1.33A 4v04A-6c9dA:
21.2		 4v04A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 VAL A 738
ALA A 756
GLU A 775
VAL A 804
ALA A 807
HIS A 872
GLY A 894
 ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 1.45A 4v04A-6fekA:
32.7		 4v04A-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 VAL A 738
ALA A 756
GLU A 775
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 0.78A 4v04A-6fekA:
32.7		 4v04A-6fekA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1edg ENDOGLUCANASE A

([Clostridium]
cellulolyticum) 		PF00150
(Cellulase) 		4 ILE A 335
TYR A 293
ILE A 304
PHE A 376
 None
 0.87A 4v04A-1edgA:
undetectable		 4v04A-1edgA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LYS A 222
MET A 240
TYR A 268
LEU A 321
 None
 0.68A 4v04A-1k9aA:
25.0		 4v04A-1k9aA:
29.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 MET A 240
TYR A 268
ARG A 313
LEU A 321
 None
 0.75A 4v04A-1k9aA:
25.0		 4v04A-1k9aA:
29.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 LYS A 608
TYR A 656
ARG A 723
LEU A 731
ILE A 740
 None
 1.31A 4v04A-1lufA:
33.6		 4v04A-1lufA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LYS A  57
ILE A  89
TYR A 107
LEU A 158
 None
 0.52A 4v04A-1u5qA:
23.6		 4v04A-1u5qA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 ARG A  22
LEU A 133
ILE A   7
PHE A 148
 MTX  A 187 (-3.3A)
None
MTX  A 187 (-3.8A)
None
 0.84A 4v04A-1u70A:
undetectable		 4v04A-1u70A:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS X  39
MET X  58
TYR X  84
LEU X 137
 STU  X 902 (-3.1A)
None
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
 0.55A 4v04A-2dq7X:
30.1		 4v04A-2dq7X:
37.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET X  58
TYR X  84
ARG X 129
LEU X 137
ILE X 146
 None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
STU  X 902 (-4.4A)
None
 1.20A 4v04A-2dq7X:
30.1		 4v04A-2dq7X:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehh DIHYDRODIPICOLINATE
SYNTHASE

(Aquifex
aeolicus) 		PF00701
(DHDPS) 		4 LYS A 200
ILE A 130
ILE A 129
PHE A 181
 None
 0.86A 4v04A-2ehhA:
undetectable		 4v04A-2ehhA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		4 LYS A  57
ILE A  89
TYR A 107
LEU A 158
 STU  A 400 ( 4.5A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
STU  A 400 ( 4.6A)
 0.55A 4v04A-2gcdA:
24.2		 4v04A-2gcdA:
26.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 273
MET A 292
ARG A 363
LEU A 371
ILE A 380
 1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-4.4A)
None
 1.34A 4v04A-2hk5A:
24.4		 4v04A-2hk5A:
38.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfw GLUTAMATE RACEMASE

(Enterococcus
faecium) 		PF01177
(Asp_Glu_race) 		4 ILE A  70
TYR A  64
LEU A  36
ILE A  10
 None
 0.80A 4v04A-2jfwA:
undetectable		 4v04A-2jfwA:
21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 273
LEU A 371
ILE A 380
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 4.3A)
 0.88A 4v04A-2og8A:
30.8		 4v04A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 292
LEU A 371
ILE A 380
PHE A 383
 1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.3A)
None
1N8  A 501 ( 4.3A)
 0.58A 4v04A-2og8A:
30.8		 4v04A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 637
TYR A 665
ARG A 777
LEU A 785
ILE A 794
 None
 1.10A 4v04A-2ogvA:
33.1		 4v04A-2ogvA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 886
LEU A 971
ILE A 980
PHE A 983
 MR9  A 301 (-4.0A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.6A)
MR9  A 301 (-4.4A)
 0.70A 4v04A-2p4iA:
25.4		 4v04A-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 904
LEU A 971
ILE A 980
PHE A 983
 MR9  A 301 (-3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.6A)
MR9  A 301 (-4.4A)
 0.77A 4v04A-2p4iA:
25.4		 4v04A-2p4iA:
42.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'

(Sulfolobus
solfataricus) 		PF04998
(RNA_pol_Rpb1_5) 		4 ILE C 250
ARG C 239
LEU C 126
ILE C 124
 None
 0.79A 4v04A-2pmzC:
undetectable		 4v04A-2pmzC:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
SO4  A 303 ( 2.9A)
None
None
 1.15A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 MET A 538
ILE A 548
TYR A 566
LEU A 633
ILE A 642
 None
 0.46A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS C  78
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 (-3.6A)
None
None
None
 0.73A 4v04A-2wtkC:
15.6		 4v04A-2wtkC:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 517
MET A 538
ILE A 548
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.5A)
None
None
None
M33  A1996 (-4.5A)
None
 1.32A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 538
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
M33  A1996 ( 4.7A)
None
M33  A1996 (-4.5A)
None
 1.30A 4v04A-3b2tA:
27.9		 4v04A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 514
ILE A 545
TYR A 563
ARG A 622
LEU A 630
 None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.61A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
None
 0.37A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 535
ILE A 545
TYR A 563
LEU A 630
ILE A 639
PHE A 489
 C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
C4F  A   1 (-4.6A)
None
C4F  A   1 (-3.7A)
 0.74A 4v04A-3c4fA:
42.7		 4v04A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 222
MET A 240
TYR A 268
LEU A 321
 None
 0.68A 4v04A-3d7uA:
25.0		 4v04A-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 240
TYR A 268
ARG A 313
LEU A 321
 None
 0.75A 4v04A-3d7uA:
25.0		 4v04A-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 204
ARG A 267
LEU A 275
ILE A 292
 VIN  A6331 ( 4.9A)
None
VIN  A6331 (-4.5A)
None
 0.75A 4v04A-3dtcA:
26.6		 4v04A-3dtcA:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  38
MET A  54
ILE A  63
LEU A 173
 None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
 0.67A 4v04A-3eb0A:
20.4		 4v04A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LYS A  38
MET A  54
ILE A  63
TYR A 119
 None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
 0.70A 4v04A-3eb0A:
20.4		 4v04A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		4 ILE A  75
TYR A  93
LEU A 143
ILE A 157
 None
 0.65A 4v04A-3gbzA:
21.8		 4v04A-3gbzA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gem SHORT CHAIN
DEHYDROGENASE

(Pseudomonas
savastanoi) 		PF13561
(adh_short_C2) 		4 ILE A  33
LEU A   9
ILE A  34
PHE A  67
 None
 0.88A 4v04A-3gemA:
undetectable		 4v04A-3gemA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 4 ILE B  95
TYR B 113
LEU B 163
ILE B 172
 None
 0.58A 4v04A-3h4jB:
16.0		 4v04A-3h4jB:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4j SNF1-LIKE PROTEIN
KINASE SSP2

(Schizosaccharomyces
pombe) 		no annotation 4 LYS B  63
ILE B  95
TYR B 113
ILE B 172
 None
 0.49A 4v04A-3h4jB:
16.0		 4v04A-3h4jB:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdt PUTATIVE KINASE

([Clostridium]
symbiosum) 		PF13189
(Cytidylate_kin2) 		4 ILE A  13
ARG A  25
LEU A 135
ILE A  14
 None
 0.88A 4v04A-3hdtA:
undetectable		 4v04A-3hdtA:
22.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 911
ARG A1021
LEU A1029
ILE A1038
 8ST  A2001 (-4.9A)
None
None
None
 0.66A 4v04A-3hngA:
34.2		 4v04A-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2d E3 SUMO-PROTEIN
LIGASE SIZ1

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 ARG A 367
LEU A 412
ILE A 414
PHE A 383
 None
 0.87A 4v04A-3i2dA:
undetectable		 4v04A-3i2dA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 LYS A  82
TYR A 131
LEU A 182
ILE A 191
 None
 0.50A 4v04A-3iecA:
22.3		 4v04A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 MET A 104
TYR A 131
ARG A 174
LEU A 182
ILE A 191
 None
 0.90A 4v04A-3iecA:
22.3		 4v04A-3iecA:
27.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 MET A 688
ILE A 697
TYR A 715
ARG A 759
LEU A 767
 None
None
GOL  A 403 (-4.1A)
None
None
 1.48A 4v04A-3kulA:
32.1		 4v04A-3kulA:
34.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  62
ILE A  94
TYR A 112
ILE A 177
 QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
 0.75A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  62
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.71A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ILE A 116
TYR A 134
LEU A 184
ILE A 193
 None
 0.60A 4v04A-3mn3A:
20.4		 4v04A-3mn3A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 134
TYR A 161
ARG A 204
LEU A 212
ILE A 221
 None
None
SEP  A 241 ( 3.4A)
None
None
 1.10A 4v04A-3nuuA:
22.9		 4v04A-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 ILE A 214
ARG A 196
LEU A 190
ILE A 206
 None
EDO  A 404 ( 4.0A)
None
None
 0.80A 4v04A-3op7A:
undetectable		 4v04A-3op7A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ova CCA-ADDING ENZYME

(Archaeoglobus
fulgidus) 		PF01909
(NTP_transf_2)
PF09249
(tRNA_NucTransf2) 		4 TYR A 392
LEU A 308
ILE A 335
PHE A 279
 A  C  22 ( 4.5A)
None
None
None
 0.83A 4v04A-3ovaA:
undetectable		 4v04A-3ovaA:
22.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		4 LYS A 578
MET A 600
TYR A 627
LEU A 683
 STU  A   1 (-3.5A)
None
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.53A 4v04A-3ppzA:
27.8		 4v04A-3ppzA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 368
MET A 388
TYR A 415
ARG A 459
LEU A 467
 STU  A   1 (-3.1A)
None
STU  A   1 (-4.7A)
None
STU  A   1 (-4.6A)
 1.24A 4v04A-3s95A:
25.4		 4v04A-3s95A:
30.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		4 ILE A 271
TYR A 205
LEU A 273
PHE A 256
 None
None
EDO  A 347 ( 4.3A)
None
 0.81A 4v04A-3tlzA:
undetectable		 4v04A-3tlzA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 514
MET A 535
ILE A 545
TYR A 563
LEU A 630
ILE A 639
 07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
None
 0.39A 4v04A-3tt0A:
41.1		 4v04A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 868
ARG A1027
LEU A1035
ILE A1044
 None
None
4TT  A2001 (-4.8A)
None
 0.50A 4v04A-3vidA:
34.7		 4v04A-3vidA:
49.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A 162
TYR A 212
LEU A 263
ILE A 272
 N13  A 501 (-2.9A)
N13  A 501 (-4.4A)
N13  A 501 (-4.5A)
None
 0.58A 4v04A-3w18A:
21.9		 4v04A-3w18A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.96A 4v04A-4cfhA:
22.7		 4v04A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
 1.08A 4v04A-4cfhA:
22.7		 4v04A-4cfhA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 655
ILE A 685
LEU A 773
ILE A 782
PHE A 785
 DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
 0.79A 4v04A-4ckrA:
30.6		 4v04A-4ckrA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 655
ILE A 685
TYR A 703
LEU A 773
ILE A 782
 DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
 0.96A 4v04A-4ckrA:
30.6		 4v04A-4ckrA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 543
ARG A 648
LEU A 656
ILE A 665
 None
 0.77A 4v04A-4f0iA:
25.8		 4v04A-4f0iA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LYS A 882
TYR A 931
LEU A 983
ILE A 992
 IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.7A)
None
 0.80A 4v04A-4gl9A:
27.5		 4v04A-4gl9A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 855
TYR A 904
LEU A 956
ILE A 965
 19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
None
 0.79A 4v04A-4hviA:
29.2		 4v04A-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		4 LYS A 158
ILE A 190
LEU A 259
ILE A 268
 None
 0.71A 4v04A-4hzsA:
27.3		 4v04A-4hzsA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 508
MET A 529
ILE A 539
TYR A 557
 ACP  A 801 (-2.7A)
None
None
None
 0.54A 4v04A-4k33A:
29.3		 4v04A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 529
ILE A 539
TYR A 557
ARG A 616
LEU A 624
ILE A 633
 None
None
None
None
ACP  A 801 (-4.4A)
None
 1.20A 4v04A-4k33A:
29.3		 4v04A-4k33A:
80.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvt E3 SUMO-PROTEIN
LIGASE PIAS3

(Homo sapiens) 		PF02891
(zf-MIZ)
PF14324
(PINIT) 		4 ARG A 333
LEU A 378
ILE A 380
PHE A 349
 None
 0.80A 4v04A-4mvtA:
undetectable		 4v04A-4mvtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 960
TYR A 980
ARG A1022
LEU A1030
ILE A1039
 None
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
None
 1.46A 4v04A-4oliA:
26.9		 4v04A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.72A 4v04A-4oliA:
26.9		 4v04A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 ILE A  70
TYR A  54
LEU A  72
ILE A 208
 None
 0.88A 4v04A-4qhbA:
undetectable		 4v04A-4qhbA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ILE A  79
TYR A  97
ARG A 140
LEU A 148
ILE A 157
 STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
None
 1.13A 4v04A-4rewA:
22.2		 4v04A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LYS A  47
ILE A  79
TYR A  97
LEU A 148
 STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
STU  A 601 (-4.2A)
 0.48A 4v04A-4rewA:
22.2		 4v04A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 ILE A 213
ARG A 191
LEU A 151
ILE A 212
 None
 0.75A 4v04A-4rxmA:
undetectable		 4v04A-4rxmA:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LYS A  37
MET A  56
TYR A  83
LEU A 136
 None
None
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
 0.73A 4v04A-4ueuA:
30.3		 4v04A-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 204
ARG A 267
LEU A 275
ILE A 292
 None
 0.67A 4v04A-4uy9A:
26.7		 4v04A-4uy9A:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 184
ARG A 262
LEU A 270
ILE A 287
 AGS  A1438 (-4.2A)
None
AGS  A1438 (-4.7A)
None
 0.67A 4v04A-4uyaA:
26.0		 4v04A-4uyaA:
32.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LYS A 503
MET A 524
ILE A 534
LEU A 619
ILE A 628
 40M  A1002 (-4.0A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-4.5A)
None
 0.50A 4v04A-4xcuA:
38.9		 4v04A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 644
MET A 665
TYR A 693
LEU A 818
 P30  A1001 ( 4.0A)
P30  A1001 (-4.4A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
 0.79A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 644
TYR A 693
LEU A 818
ILE A 827
 P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.53A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 644
TYR A 693
LEU A 818
PHE A 830
 P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
P30  A1001 ( 4.1A)
 0.71A 4v04A-4xufA:
24.2		 4v04A-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 490
ILE A 522
TYR A 541
LEU A 595
 4CV  A 801 (-3.9A)
4CV  A 801 ( 4.2A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
 0.69A 4v04A-4yffA:
24.5		 4v04A-4yffA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 514
MET A 535
TYR A 563
ARG A 622
 38O  A1769 ( 3.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
None
 0.85A 4v04A-5a46A:
43.5		 4v04A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 MET A 535
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
None
 0.23A 4v04A-5a46A:
43.5		 4v04A-5a46A:
98.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.88A 4v04A-5ci7A:
18.6		 4v04A-5ci7A:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.75A 4v04A-5f1zA:
22.9		 4v04A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 None
None
SEP  A 909 ( 3.0A)
PP1  A2012 (-4.6A)
None
 1.33A 4v04A-5fm2A:
33.7		 4v04A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 627
MET A 648
TYR A 676
LEU A 825
 748  A1001 (-4.0A)
748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
 0.68A 4v04A-5grnA:
25.8		 4v04A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A 648
TYR A 676
LEU A 825
ILE A 834
 748  A1001 (-3.4A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.49A 4v04A-5grnA:
25.8		 4v04A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A  66
TYR A  84
ARG A 132
ILE A 149
 032  A 401 (-4.4A)
032  A 401 (-4.2A)
None
None
 0.80A 4v04A-5hesA:
25.7		 4v04A-5hesA:
30.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A  45
ILE A  66
ARG A 132
ILE A 149
 032  A 401 (-4.4A)
032  A 401 (-4.4A)
None
None
 0.76A 4v04A-5hesA:
25.7		 4v04A-5hesA:
30.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LYS A  79
MET A  99
TYR A 132
LEU A 187
 IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.70A 4v04A-5i3oA:
21.6		 4v04A-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  79
TYR A  99
LEU A 158
ILE A 171
 6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
None
 0.81A 4v04A-5idnA:
15.5		 4v04A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
None
 1.09A 4v04A-5isoA:
22.4		 4v04A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LYS A  45
ILE A  77
TYR A  95
LEU A 146
 STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
 0.73A 4v04A-5isoA:
22.4		 4v04A-5isoA:
19.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 665
ILE A 695
ARG A 757
LEU A 765
 None
None
None
6P6  A1001 (-4.5A)
 0.81A 4v04A-5l6oA:
31.5		 4v04A-5l6oA:
31.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ILE A 174
ARG A 235
LEU A 243
ILE A 252
 None
None
9FS  A 501 (-4.7A)
None
 0.84A 4v04A-5vo1A:
25.7		 4v04A-5vo1A:
35.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 TYR A 143
ARG A 198
LEU A 206
ILE A 215
 ANP  A1000 (-4.3A)
None
ANP  A1000 (-4.5A)
None
 0.70A 4v04A-5xd6A:
21.6		 4v04A-5xd6A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 4 ILE A 433
ARG A 474
LEU A 381
PHE A 461
 None
 0.76A 4v04A-5yxgA:
undetectable		 4v04A-5yxgA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z24 PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 4 ILE A 433
ARG A 474
LEU A 381
PHE A 461
 None
 0.88A 4v04A-5z24A:
undetectable		 4v04A-5z24A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 LYS A  89
TYR A 138
LEU A 189
ILE A 198
 None
 0.76A 4v04A-6c9dA:
21.2		 4v04A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 MET A 111
TYR A 138
ARG A 181
LEU A 189
ILE A 198
 None
 1.02A 4v04A-6c9dA:
21.2		 4v04A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 5 LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 1.05A 4v04A-6f3dA:
23.0		 4v04A-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 5 ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
FMT  A1101 (-2.8A)
ADN  A1104 (-4.3A)
None
 1.37A 4v04A-6fekA:
32.7		 4v04A-6fekA:
18.64