SIMILAR PATTERNS OF AMINO ACIDS FOR 4V01_B_0LIB1770_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
GLU A 236
MET A 240
LEU A 305
HIS A 312
 None
 0.63A 4v01B-1k9aA:
30.9		 4v01B-1k9aA:
29.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
LEU A 715
HIS A 722
ALA A 741
ASP A 742
 None
 0.62A 4v01B-1lufA:
34.3		 4v01B-1lufA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 288
GLU A 305
MET A 309
LEU A 373
HIS A 380
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
P16  A   2 (-3.5A)
 0.59A 4v01B-1opkA:
30.1		 4v01B-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 230
GLU A 245
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.57A 4v01B-1py5A:
25.1		 4v01B-1py5A:
29.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 None
 0.93A 4v01B-1rjbA:
33.3		 4v01B-1rjbA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 621
GLU A 640
LEU A 783
CYH A 788
HIS A 790
ASP A 810
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
 0.60A 4v01B-1t46A:
26.9		 4v01B-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
GLU A 386
MET A 390
ALA A 417
LEU A 452
HIS A 459
 STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
None
None
 0.65A 4v01B-1u59A:
30.7		 4v01B-1u59A:
35.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 6 ALA A  85
GLU A 125
VAL A 118
ALA A  59
LEU A 107
ALA A  92
 None
 1.37A 4v01B-1ufoA:
undetectable		 4v01B-1ufoA:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
GLU X  54
MET X  58
HIS X 128
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 ( 4.1A)
 0.66A 4v01B-2dq7X:
30.8		 4v01B-2dq7X:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 184
GLU A 201
LEU A 274
HIS A 281
ALA A 319
 None
 0.78A 4v01B-2eu9A:
21.5		 4v01B-2eu9A:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 659
GLU A 678
MET A 682
LEU A 745
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
None
ADP  A 400 ( 4.8A)
 1.08A 4v01B-2henA:
24.2		 4v01B-2henA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
GLU A 286
MET A 290
LEU A 354
HIS A 361
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.86A 4v01B-2hz0A:
30.8		 4v01B-2hz0A:
40.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ALA A 452
GLU A 471
MET A 475
LEU A 537
HIS A 544
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
 0.58A 4v01B-2j0jA:
32.6		 4v01B-2j0jA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 GLU A 471
MET A 475
LEU A 537
HIS A 544
ASP A 564
 4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.83A 4v01B-2j0jA:
32.6		 4v01B-2j0jA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 452
GLU A 471
MET A 475
LEU A 537
HIS A 544
 BII  A1687 (-3.5A)
None
None
None
None
 0.82A 4v01B-2jkmA:
32.2		 4v01B-2jkmA:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
GLU A 288
MET A 292
HIS A 362
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.59A 4v01B-2og8A:
31.6		 4v01B-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
GLU A 633
MET A 637
LEU A 769
CYH A 774
HIS A 776
 None
 0.53A 4v01B-2ogvA:
32.8		 4v01B-2ogvA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
GLU A 633
MET A 637
LEU A 769
HIS A 776
ASP A 796
 None
 0.73A 4v01B-2ogvA:
32.8		 4v01B-2ogvA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
ALA A 905
LEU A 955
HIS A 962
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-3.6A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.61A 4v01B-2p4iA:
13.0		 4v01B-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 905
LEU A 955
HIS A 962
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.6A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 1.36A 4v01B-2p4iA:
13.0		 4v01B-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 515
GLU A 534
MET A 537
MET A 538
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 None
 0.70A 4v01B-2psqA:
35.5		 4v01B-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.55A 4v01B-2xikA:
19.5		 4v01B-2xikA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 651
MET A 674
LEU A 737
HIS A 744
ASP A 764
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.9A)
None
None
None
 0.76A 4v01B-2xyuA:
27.1		 4v01B-2xyuA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1028
GLU A1047
MET A1051
LEU A1123
HIS A1130
 S91  A   1 (-3.2A)
None
None
None
None
 0.81A 4v01B-2z8cA:
22.8		 4v01B-2z8cA:
38.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
MET A 538
VAL A 564
LEU A 617
CYH A 622
HIS A 624
 M33  A1996 (-3.3A)
None
None
None
None
None
None
 0.92A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 515
MET A 537
MET A 538
VAL A 564
ALA A 567
LEU A 617
CYH A 622
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
None
 0.76A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 515
MET A 538
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
M33  A1996 (-3.8A)
None
None
None
None
 0.56A 4v01B-3b2tA:
26.7		 4v01B-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A1108
GLU A1127
MET A1131
LEU A1195
HIS A1202
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.81A 4v01B-3c1xA:
27.2		 4v01B-3c1xA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
GLU A 531
MET A 535
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
 0.41A 4v01B-3c4fA:
40.9		 4v01B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 512
MET A 534
MET A 535
VAL A 561
ALA A 564
LEU A 614
CYH A 619
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
 0.67A 4v01B-3c4fA:
40.9		 4v01B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU A 531
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
PHE A 489
 None
C4F  A   1 (-3.5A)
None
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.74A 4v01B-3c4fA:
40.9		 4v01B-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 220
GLU A 236
MET A 240
LEU A 305
HIS A 312
 None
 0.63A 4v01B-3d7uA:
31.1		 4v01B-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 663
GLU A 682
MET A 686
LEU A 749
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.75A 4v01B-3dkoA:
32.4		 4v01B-3dkoA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 859
GLU A 878
VAL A 909
LEU A1013
CYH A1018
HIS A1020
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 0.50A 4v01B-3hngA:
34.7		 4v01B-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 907
ALA A 859
LEU A1013
CYH A1018
HIS A1020
ASP A1040
 8ST  A2001 (-4.5A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 1.16A 4v01B-3hngA:
34.7		 4v01B-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  80
MET A 104
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 0.93A 4v01B-3iecA:
22.5		 4v01B-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLU A 100
MET A 104
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 1.17A 4v01B-3iecA:
22.5		 4v01B-3iecA:
27.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
GLU A 684
MET A 688
LEU A 751
HIS A 758
 None
 0.57A 4v01B-3kulA:
10.4		 4v01B-3kulA:
34.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.78A 4v01B-3lm5A:
24.1		 4v01B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ALA A 229
GLU A 244
LEU A 315
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.74A 4v01B-3mdyA:
25.0		 4v01B-3mdyA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
MET A 134
ALA A 162
HIS A 203
ASP A 223
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
JOZ  A 361 (-3.8A)
None
SO4  A   5 ( 4.5A)
 0.89A 4v01B-3nuuA:
23.3		 4v01B-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
MET A 134
ALA A 162
LEU A 196
HIS A 203
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
JOZ  A 361 (-3.8A)
None
None
 0.70A 4v01B-3nuuA:
23.3		 4v01B-3nuuA:
26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
GLU A 596
MET A 600
LEU A 665
HIS A 674
 STU  A   1 (-3.3A)
None
None
None
None
 0.59A 4v01B-3ppzA:
28.6		 4v01B-3ppzA:
31.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 512
GLU A 531
MET A 534
MET A 535
VAL A 561
ALA A 564
LEU A 614
CYH A 619
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
None
None
 0.68A 4v01B-3tt0A:
39.4		 4v01B-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
GLU A 531
MET A 535
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
None
None
None
07J  A   1 (-3.2A)
 0.43A 4v01B-3tt0A:
39.4		 4v01B-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
GLU A 588
LEU A 670
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.91A 4v01B-3v5qA:
32.4		 4v01B-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
 0.77A 4v01B-3vidA:
34.9		 4v01B-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
 0.53A 4v01B-3vidA:
34.9		 4v01B-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
None
 0.46A 4v01B-3wzdA:
26.6		 4v01B-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
 0.53A 4v01B-4agdA:
35.1		 4v01B-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 866
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
B49  A2000 (-4.8A)
None
None
None
 0.74A 4v01B-4agdA:
35.1		 4v01B-4agdA:
49.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  63
GLU A  81
LEU A 148
HIS A 155
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
None
XZN  A1317 ( 4.3A)
 0.78A 4v01B-4bc6A:
21.1		 4v01B-4bc6A:
28.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
GLU A 672
MET A 676
LEU A 757
HIS A 764
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.66A 4v01B-4ckrA:
31.3		 4v01B-4ckrA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
MET A 676
LEU A 757
HIS A 764
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.82A 4v01B-4ckrA:
31.3		 4v01B-4ckrA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.68A 4v01B-4crsA:
20.8		 4v01B-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dez DNA POLYMERASE IV 1

(Mycolicibacterium
smegmatis) 		PF00817
(IMS) 		6 ALA A 158
GLU A 126
VAL A 142
ALA A 154
LEU A 115
ASP A 120
 None
 1.40A 4v01B-4dezA:
undetectable		 4v01B-4dezA:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 400
GLU A 420
MET A 424
ALA A 451
LEU A 485
HIS A 492
 0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.0A)
None
None
 0.85A 4v01B-4f4pA:
29.4		 4v01B-4f4pA:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
GLU A  71
VAL A 100
LEU A 137
HIS A 144
 STU  A 401 (-3.2A)
None
None
None
None
 0.77A 4v01B-4fr4A:
20.8		 4v01B-4fr4A:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
GLU A 871
LEU A 940
CYH A 945
HIS A 947
ALA A 966
 19S  A1201 (-3.3A)
None
None
None
None
19S  A1201 ( 4.1A)
 0.55A 4v01B-4hviA:
29.9		 4v01B-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 156
GLU A 177
ALA A 208
LEU A 243
HIS A 250
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.8A)
None
None
 0.65A 4v01B-4id7A:
29.3		 4v01B-4id7A:
37.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id9 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		5 MET A 152
VAL A  61
ALA A  54
ALA A  92
ASP A  91
 None
 0.81A 4v01B-4id9A:
undetectable		 4v01B-4id9A:
22.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 506
GLU A 525
MET A 529
VAL A 555
ALA A 558
LEU A 608
HIS A 615
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
None
 0.66A 4v01B-4k33A:
26.9		 4v01B-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 506
MET A 528
MET A 529
VAL A 555
ALA A 558
LEU A 608
HIS A 615
ALA A 634
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
None
 0.79A 4v01B-4k33A:
26.9		 4v01B-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 506
MET A 528
MET A 529
VAL A 555
LEU A 608
CYH A 613
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.7A)
None
None
 1.25A 4v01B-4k33A:
26.9		 4v01B-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 506
MET A 529
VAL A 555
ALA A 558
HIS A 615
ALA A 634
ASP A 635
 ACP  A 801 (-3.3A)
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
MG  A 802 ( 3.0A)
 0.98A 4v01B-4k33A:
26.9		 4v01B-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A  61
GLU A  77
ALA A 107
LEU A 144
HIS A 154
 1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
None
None
 0.76A 4v01B-4l52A:
21.3		 4v01B-4l52A:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  54
GLU A  70
MET A  74
LEU A 137
HIS A 144
ALA A 163
 GOL  A 404 ( 3.1A)
None
None
None
None
GOL  A 403 ( 3.0A)
 0.84A 4v01B-4lg4A:
18.1		 4v01B-4lg4A:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 ALA A  99
GLU A 117
MET A 121
LEU A 183
HIS A 190
 STU  A 601 (-3.3A)
None
None
None
None
 0.82A 4v01B-4mvfA:
18.9		 4v01B-4mvfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA B  51
GLU B  70
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.54A 4v01B-4o27B:
18.8		 4v01B-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 ALA A  61
GLU A  94
MET A  97
MET A  98
HIS A 173
ASP A 193
 046  A 401 ( 4.6A)
046  A 401 (-3.7A)
046  A 401 (-3.9A)
046  A 401 (-3.5A)
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 1.06A 4v01B-4o2zA:
21.8		 4v01B-4o2zA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 GLU A  94
MET A  97
MET A  98
LEU A 166
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.9A)
046  A 401 (-3.5A)
None
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.69A 4v01B-4o2zA:
21.8		 4v01B-4o2zA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA B 390
VAL B 434
LEU B 475
HIS B 483
ALA B 502
 ACP  B 801 (-3.2A)
ACP  B 801 (-4.8A)
None
None
None
 0.73A 4v01B-4oavB:
17.6		 4v01B-4oavB:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
P30  A1001 ( 4.3A)
None
 0.61A 4v01B-4rt7A:
26.2		 4v01B-4rt7A:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.53A 4v01B-4tptA:
21.6		 4v01B-4tptA:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
GLU A  52
MET A  56
HIS A 127
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
None
None
 1.06A 4v01B-4ueuA:
30.8		 4v01B-4ueuA:
41.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
GLU A  52
MET A  56
LEU A 120
HIS A 127
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
None
None
 0.94A 4v01B-4ueuA:
30.8		 4v01B-4ueuA:
41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  72
GLU A  90
MET A  94
LEU A 165
HIS A 174
 KSA  A 405 (-3.2A)
None
None
None
None
 0.81A 4v01B-4wsqA:
22.2		 4v01B-4wsqA:
25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 501
GLU A 520
MET A 524
VAL A 550
ALA A 553
LEU A 603
CYH A 608
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
None
40M  A1002 (-3.0A)
 0.36A 4v01B-4xcuA:
37.8		 4v01B-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 ALA B 288
MET B 309
LEU B 373
HIS B 380
ALA B 399
 1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
None
1N1  B 601 (-3.5A)
 0.78A 4v01B-4xeyB:
31.4		 4v01B-4xeyB:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
None
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.80A 4v01B-4xufA:
33.6		 4v01B-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
GLU A 661
MET A 664
MET A 665
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.4A)
None
 0.72A 4v01B-4xufA:
33.6		 4v01B-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 488
GLU A 509
LEU A 577
HIS A 586
ALA A 605
 4CV  A 801 (-3.5A)
None
None
None
4CV  A 801 ( 3.9A)
 0.82A 4v01B-4yffA:
25.2		 4v01B-4yffA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
MET A 534
MET A 535
VAL A 561
ALA A 564
LEU A 614
CYH A 619
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
EDO  A1766 (-3.5A)
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
None
EDO  A1766 ( 4.4A)
 0.48A 4v01B-5a46A:
41.4		 4v01B-5a46A:
98.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ALA A  83
GLU A 103
ALA A 135
HIS A 176
ALA A 195
 5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
5RC  A4000 ( 3.9A)
 0.81A 4v01B-5es1A:
22.9		 4v01B-5es1A:
28.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
None
 0.62A 4v01B-5fm2A:
34.1		 4v01B-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
GLU A 644
MET A 648
LEU A 809
CYH A 814
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.46A 4v01B-5grnA:
27.1		 4v01B-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
MET A1131
LEU A1195
HIS A1202
ALA A1221
 63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
 0.60A 4v01B-5horA:
27.1		 4v01B-5horA:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.48A 4v01B-5idnA:
7.4		 4v01B-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  43
GLU A  61
MET A  64
MET A  65
LEU A 127
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
None
None
6G2  A 901 ( 4.2A)
 0.94A 4v01B-5j5tA:
21.4		 4v01B-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 297
GLU A 315
MET A 319
LEU A 380
HIS A 387
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
None
 0.79A 4v01B-5kbrA:
22.2		 4v01B-5kbrA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 119
GLU A 136
LEU A 215
HIS A 223
ALA A 540
 W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
None
DMS  A 717 ( 4.5A)
 0.67A 4v01B-5myvA:
19.6		 4v01B-5myvA:
24.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 617
MET A 641
LEU A 714
HIS A 721
ALA A 740
 7AE  A1000 (-3.3A)
None
None
None
7AE  A1000 ( 3.7A)
 0.59A 4v01B-5td2A:
29.9		 4v01B-5td2A:
41.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  42
GLU A  61
MET A  65
LEU A 135
HIS A 142
 None
 0.73A 4v01B-5tqwA:
14.5		 4v01B-5tqwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 ALA A  49
GLU A  69
MET A  73
LEU A 132
HIS A 141
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
None
None
None
 0.80A 4v01B-5wnmA:
27.8		 4v01B-5wnmA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 107
GLU A 124
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
None
None
EMH  A 705 ( 4.0A)
 0.52A 4v01B-5xv7A:
20.6		 4v01B-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ALA A  87
GLU A 107
MET A 111
ALA A 139
HIS A 180
ALA A 199
 None
 0.76A 4v01B-6c9dA:
21.6		 4v01B-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
GLU A 236
LEU A 303
HIS A 310
ALA A 329
 F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
None
None
F6J  A 501 ( 4.0A)
 0.81A 4v01B-6cmjA:
22.2		 4v01B-6cmjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.58A 4v01B-6cnhA:
22.1		 4v01B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.59A 4v01B-6cnhA:
22.1		 4v01B-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 5 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 0.57A 4v01B-6fekA:
33.2		 4v01B-6fekA:
18.64