SIMILAR PATTERNS OF AMINO ACIDS FOR 4V01_A_0LIA1776_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 588
LYS A 608
TYR A 656
ARG A 723
LEU A 731
ILE A 740
 None
 1.03A 4v01A-1lufA:
34.0		 4v01A-1lufA:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
TYR A 693
CYH A 807
LEU A 818
ILE A 827
 None
 0.40A 4v01A-1rjbA:
33.1		 4v01A-1rjbA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
LYS A 623
TYR A 672
ARG A 791
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.4A)
 1.07A 4v01A-1t46A:
26.9		 4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
VAL A 603
TYR A 672
CYH A 788
ARG A 791
LEU A 799
ILE A 808
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 ( 4.0A)
STI  A   3 (-2.8A)
None
STI  A   3 (-4.4A)
None
 0.86A 4v01A-1t46A:
26.9		 4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
VAL A 352
LYS A 369
LEU A 468
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
None
 0.47A 4v01A-1u59A:
30.3		 4v01A-1u59A:
35.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
LYS A  57
ILE A  89
TYR A 107
ARG A 150
LEU A 158
 None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.73A 4v01A-1u5qA:
23.6		 4v01A-1u5qA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
TYR A  86
ARG A 129
LEU A 137
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
None
 0.55A 4v01A-1zltA:
21.1		 4v01A-1zltA:
28.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
VAL X  25
TYR X  84
LEU X 137
ILE X 146
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
None
 0.35A 4v01A-2dq7X:
30.3		 4v01A-2dq7X:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
LYS A  57
ILE A  89
TYR A 107
ARG A 150
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 ( 4.5A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
SEP  A 181 ( 2.9A)
STU  A 400 ( 4.6A)
 0.69A 4v01A-2gcdA:
24.5		 4v01A-2gcdA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
VAL A  63
LYS A  78
ARG A 169
LEU A 177
ILE A 189
 None
 1.05A 4v01A-2hw6A:
19.5		 4v01A-2hw6A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
 0.72A 4v01A-2i0eA:
13.1		 4v01A-2i0eA:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
LYS A 273
ARG A 363
LEU A 371
ILE A 380
 None
None
1N8  A 501 ( 3.4A)
None
1N8  A 501 ( 4.3A)
None
 1.47A 4v01A-2og8A:
31.3		 4v01A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
TYR A 318
ARG A 363
LEU A 371
ILE A 380
 None
None
1N8  A 501 ( 3.7A)
None
1N8  A 501 ( 4.3A)
None
 1.16A 4v01A-2og8A:
31.3		 4v01A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
TYR A 665
CYH A 774
ARG A 777
LEU A 785
ILE A 794
 None
 0.87A 4v01A-2ogvA:
32.9		 4v01A-2ogvA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 838
LYS A 855
ILE A 886
TYR A 904
LEU A 971
ILE A 980
 MR9  A 301 (-4.6A)
MR9  A 301 ( 4.6A)
MR9  A 301 (-4.0A)
MR9  A 301 (-3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.6A)
 1.03A 4v01A-2p4iA:
27.1		 4v01A-2p4iA:
42.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
LYS A  48
ILE A  87
ARG A 148
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 1.05A 4v01A-2phkA:
21.6		 4v01A-2phkA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
ILE A 548
TYR A 566
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
None
 0.92A 4v01A-2psqA:
35.8		 4v01A-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU C  55
VAL C  63
LYS C  78
ILE C 111
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
None
 0.73A 4v01A-2wtkC:
22.3		 4v01A-2wtkC:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
ILE A 548
TYR A 566
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
M33  A1996 ( 4.7A)
None
None
M33  A1996 (-4.5A)
None
 0.97A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 517
ILE A 548
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.5A)
None
None
None
M33  A1996 (-4.5A)
None
 1.21A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
None
 0.71A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
CYH A 619
LEU A 630
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.86A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
ILE A  62
 DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
None
 1.17A 4v01A-3eb0A:
20.3		 4v01A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
LEU A 173
 DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
 0.80A 4v01A-3eb0A:
20.3		 4v01A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		6 VAL A  29
ILE A  75
CYH A 132
ARG A 135
LEU A 143
ILE A 157
 None
 0.92A 4v01A-3gbzA:
16.6		 4v01A-3gbzA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		6 VAL A  29
ILE A  75
TYR A  93
ARG A 135
LEU A 143
ILE A 157
 None
 0.94A 4v01A-3gbzA:
16.6		 4v01A-3gbzA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 833
VAL A 841
TYR A 911
ARG A1021
LEU A1029
ILE A1038
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.9A)
None
None
None
 0.79A 4v01A-3hngA:
34.2		 4v01A-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		6 LEU A 226
VAL A 234
ILE A 286
ARG A 346
LEU A 354
ILE A 366
 None
 1.26A 4v01A-3i6uA:
20.6		 4v01A-3i6uA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 680
VAL A 689
ILE A 729
ARG A 796
LEU A 804
ILE A 826
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
None
 0.76A 4v01A-3lj0A:
21.6		 4v01A-3lj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
VAL A  47
LYS A  62
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.79A 4v01A-3lm5A:
23.3		 4v01A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  61
VAL A  69
ILE A 116
TYR A 134
LEU A 184
ILE A 193
 None
 0.97A 4v01A-3mn3A:
20.7		 4v01A-3mn3A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
VAL A  57
LYS A  72
TYR A 122
ARG A 165
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
TPO  A 197 ( 3.1A)
XFE  A 351 (-4.6A)
 0.92A 4v01A-3mvjA:
20.2		 4v01A-3mvjA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
VAL A  96
TYR A 161
ARG A 204
LEU A 212
ILE A 221
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
None
SEP  A 241 ( 3.4A)
None
None
 0.78A 4v01A-3nuuA:
22.9		 4v01A-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.3A)
ANP  A 800 (-4.2A)
TPO  A 500 ( 2.9A)
None
 0.99A 4v01A-3pfqA:
19.0		 4v01A-3pfqA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
LEU A 630
ILE A 544
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
None
 1.36A 4v01A-3tt0A:
39.7		 4v01A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
LEU A 630
ILE A 639
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
None
 0.47A 4v01A-3tt0A:
39.7		 4v01A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
LYS A 572
TYR A 619
LEU A 686
ILE A 695
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
0F4  A 902 (-4.2A)
0F4  A 902 (-4.5A)
0F4  A 902 (-4.6A)
 0.67A 4v01A-3v5qA:
32.7		 4v01A-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
LYS A 868
CYH A1024
ARG A1027
LEU A1035
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
None
4TT  A2001 (-4.8A)
None
 0.58A 4v01A-3vidA:
34.7		 4v01A-3vidA:
49.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
VAL A 147
LYS A 162
TYR A 212
LEU A 263
ILE A 272
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 (-4.4A)
N13  A 501 (-4.5A)
None
 0.66A 4v01A-3w18A:
22.3		 4v01A-3w18A:
28.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
ARG A1027
LEU A1035
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.8A)
None
 0.93A 4v01A-3wzdA:
26.5		 4v01A-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
CYH A1024
ARG A1027
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
 1.08A 4v01A-3wzdA:
26.5		 4v01A-3wzdA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  83
VAL A  91
TYR A 156
LEU A 207
ILE A 216
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-4.2A)
VX6  A 500 (-4.6A)
None
 0.43A 4v01A-4af3A:
19.8		 4v01A-4af3A:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
CYH A1024
LEU A1035
ILE A1044
 B49  A2000 (-3.7A)
None
None
B49  A2000 (-4.5A)
None
 0.50A 4v01A-4agdA:
34.8		 4v01A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 560
VAL A 568
LYS A 588
TYR A 635
ARG A 691
LEU A 699
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-4.2A)
None
 0.71A 4v01A-4at3A:
31.0		 4v01A-4at3A:
37.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
VAL A 254
LYS A 269
ILE A 302
TYR A 320
ARG A 363
LEU A 371
ILE A 380
 None
 0.86A 4v01A-4c0tA:
22.4		 4v01A-4c0tA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 LEU A 246
VAL A 254
LYS A 269
TYR A 320
LEU A 371
ILE A 370
 None
 1.22A 4v01A-4c0tA:
22.4		 4v01A-4c0tA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 (-4.3A)
None
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.84A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
 0.93A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ILE A  76
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
None
 1.21A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
LYS A 655
ILE A 685
TYR A 703
ARG A 765
LEU A 773
ILE A 782
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
 1.31A 4v01A-4ckrA:
30.8		 4v01A-4ckrA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.79A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.48A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		6 LEU A  16
VAL A  24
TYR A  89
ARG A 132
LEU A 140
ILE A 149
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.7A)
ANP  A 300 (-4.3A)
None
ANP  A 300 (-4.7A)
None
 1.01A 4v01A-4eqmA:
21.8		 4v01A-4eqmA:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
VAL A 523
LYS A 543
TYR A 590
ARG A 648
LEU A 656
ILE A 665
 None
 0.88A 4v01A-4f0iA:
26.5		 4v01A-4f0iA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
VAL A 863
LYS A 882
TYR A 931
LEU A 983
ILE A 992
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.7A)
None
 0.63A 4v01A-4gl9A:
27.8		 4v01A-4gl9A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
LYS A 855
TYR A 904
LEU A 956
ILE A 883
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
None
 1.13A 4v01A-4hviA:
29.5		 4v01A-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
LYS A 855
TYR A 904
LEU A 956
ILE A 965
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
None
 0.63A 4v01A-4hviA:
29.5		 4v01A-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 LEU A 132
VAL A 140
LYS A 158
ILE A 190
ARG A 251
LEU A 259
ILE A 268
 None
 1.08A 4v01A-4hzsA:
27.5		 4v01A-4hzsA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 132
VAL A 140
ILE A 190
LEU A 259
ILE A 268
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-4.3A)
1G0  A 401 (-4.6A)
None
 0.49A 4v01A-4id7A:
12.9		 4v01A-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
ILE A 539
TYR A 557
ARG A 616
LEU A 624
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
None
None
None
ACP  A 801 (-4.4A)
None
 0.80A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
ILE A 539
TYR A 557
CYH A 613
LEU A 624
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
None
None
None
ACP  A 801 (-4.4A)
None
 0.48A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
LYS A 508
ILE A 539
TYR A 557
ARG A 616
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
None
None
None
 0.96A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
LYS A 508
ILE A 539
TYR A 557
CYH A 613
ILE A 538
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
None
None
None
 1.37A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
LYS A 508
ILE A 539
TYR A 557
CYH A 613
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
None
None
None
 0.69A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A 959
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 1.22A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.71A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 930
ILE A 960
TYR A 980
ARG A1022
LEU A1030
ILE A1039
 None
None
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
None
 1.16A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
LYS A 650
TYR A 703
ARG A 745
LEU A 753
 None
None
None
None
TPO  A 780 ( 2.8A)
None
 0.96A 4v01A-4otdA:
21.2		 4v01A-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 0.69A 4v01A-4otdA:
21.2		 4v01A-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  24
VAL A  32
ILE A  79
TYR A  97
ARG A 140
LEU A 148
ILE A 157
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
None
 0.93A 4v01A-4rewA:
22.4		 4v01A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  24
VAL A  32
LYS A  47
ILE A  79
TYR A  97
ARG A 140
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
 0.95A 4v01A-4rewA:
22.4		 4v01A-4rewA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
LYS A 644
TYR A 693
CYH A 807
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
None
P30  A1001 (-4.6A)
 0.68A 4v01A-4rt7A:
26.5		 4v01A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
TYR A 693
CYH A 807
LEU A 818
ILE A 827
 P30  A1001 (-3.8A)
None
P30  A1001 (-4.1A)
None
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
 0.34A 4v01A-4rt7A:
26.5		 4v01A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
LYS A  37
TYR A  83
ARG A 128
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.8A)
 0.96A 4v01A-4ueuA:
30.1		 4v01A-4ueuA:
41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
VAL A 112
LYS A 127
TYR A 177
ARG A 220
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
TPO  A 252 ( 2.9A)
ATP  A 501 (-4.5A)
 0.86A 4v01A-4wb7A:
20.2		 4v01A-4wb7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
LYS A 216
ARG A 313
LEU A 321
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-4.9A)
None
 0.88A 4v01A-4wboA:
22.1		 4v01A-4wboA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
VAL A 481
ILE A 534
ARG A 611
LEU A 619
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
None
 0.78A 4v01A-4xcuA:
37.9		 4v01A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
LYS A 644
TYR A 693
ARG A 810
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 1.27A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
LYS A 644
TYR A 693
CYH A 807
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.58A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 577
VAL A 586
ILE A 626
ARG A 687
LEU A 695
ILE A 709
 None
 0.92A 4v01A-4z7gA:
19.6		 4v01A-4z7gA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
None
 0.50A 4v01A-5a46A:
42.1		 4v01A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ILE A 545
TYR A 563
CYH A 619
ARG A 622
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
None
None
 0.88A 4v01A-5a46A:
42.1		 4v01A-5a46A:
98.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 4.3A)
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.47A 4v01A-5ci7A:
17.5		 4v01A-5ci7A:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.61A 4v01A-5f1zA:
28.5		 4v01A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
VAL A 911
LYS A 930
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.50A 4v01A-5f1zA:
28.5		 4v01A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
None
None
SEP  A 909 ( 3.0A)
PP1  A2012 (-4.6A)
None
 0.94A 4v01A-5fm2A:
33.7		 4v01A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
LYS A 758
ILE A 788
TYR A 806
ARG A 873
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
None
None
SEP  A 909 ( 3.0A)
None
 1.08A 4v01A-5fm2A:
33.7		 4v01A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
TYR A 676
CYH A 814
ARG A 817
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.81A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
VAL A 607
LYS A 627
TYR A 676
ARG A 817
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
 0.98A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
VAL A 607
TYR A 676
ARG A 817
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.71A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
VAL A  65
LYS A  79
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.39A 4v01A-5i3oA:
21.7		 4v01A-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  35
ILE A  79
TYR A  99
ARG A 150
LEU A 158
ILE A 171
 6A7  A 401 ( 4.5A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
None
6A7  A 401 (-4.8A)
None
 0.76A 4v01A-5idnA:
13.7		 4v01A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 VAL A  32
LYS A  47
TYR A  96
ARG A 139
LEU A 147
ILE A 159
 None
None
PO4  A 401 (-4.8A)
None
None
None
 1.29A 4v01A-5ig1A:
23.2		 4v01A-5ig1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
None
 1.02A 4v01A-5isoA:
22.6		 4v01A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
 1.21A 4v01A-5isoA:
22.6		 4v01A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
VAL A  32
TYR A  97
LEU A 153
ILE A 162
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
None
9WS  A 401 (-4.6A)
None
 0.47A 4v01A-5w5jA:
23.8		 4v01A-5w5jA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
LYS A 919
TYR A 965
LEU A1017
ILE A1026
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
None
 0.82A 4v01A-5wnoA:
27.9		 4v01A-5wnoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 VAL A  74
LYS A  89
TYR A 138
ARG A 181
LEU A 189
ILE A 198
 None
 0.88A 4v01A-6c9dA:
21.2		 4v01A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 VAL A 200
LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 0.69A 4v01A-6f3dA:
22.7		 4v01A-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 LEU A 730
VAL A 738
ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
FMT  A1101 (-2.8A)
ADN  A1104 (-4.3A)
None
 0.98A 4v01A-6fekA:
32.6		 4v01A-6fekA:
18.64