SIMILAR PATTERNS OF AMINO ACIDS FOR 4V01_A_0LIA1776

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
GLU A 236
MET A 240
LEU A 305
HIS A 312
 None
 0.71A 4v01A-1k9aA:
30.4		 4v01A-1k9aA:
29.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
LEU A 715
HIS A 722
ALA A 741
ASP A 742
 None
 0.69A 4v01A-1lufA:
34.0		 4v01A-1lufA:
38.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
GLU A 305
MET A 309
ILE A 312
LEU A 373
HIS A 380
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
None
P16  A   2 (-3.5A)
 0.85A 4v01A-1opkA:
29.9		 4v01A-1opkA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 230
GLU A 245
LEU A 316
HIS A 331
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 ( 4.2A)
 0.62A 4v01A-1py5A:
24.9		 4v01A-1py5A:
29.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 None
 0.98A 4v01A-1rjbA:
33.1		 4v01A-1rjbA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 621
GLU A 640
HIS A 790
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.82A 4v01A-1t46A:
26.9		 4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 621
GLU A 640
LEU A 783
HIS A 790
ASP A 810
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
 0.69A 4v01A-1t46A:
26.9		 4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
GLU A 386
MET A 390
ALA A 417
LEU A 452
HIS A 459
 STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
None
None
 0.72A 4v01A-1u59A:
30.3		 4v01A-1u59A:
35.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufo HYPOTHETICAL PROTEIN
TT1662

(Thermus
thermophilus) 		no annotation 6 ALA A  85
GLU A 125
VAL A 118
ALA A  59
LEU A 107
ALA A  92
 None
 1.37A 4v01A-1ufoA:
undetectable		 4v01A-1ufoA:
23.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
GLU X  54
MET X  58
HIS X 128
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 ( 4.1A)
 0.70A 4v01A-2dq7X:
30.3		 4v01A-2dq7X:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
GLU A 201
ILE A 208
LEU A 274
HIS A 281
ALA A 319
 None
 1.10A 4v01A-2eu9A:
21.0		 4v01A-2eu9A:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 659
GLU A 678
MET A 682
LEU A 745
HIS A 752
ASP A 772
 ADP  A 400 (-3.2A)
ADP  A 400 ( 4.9A)
None
None
None
ADP  A 400 ( 4.8A)
 1.12A 4v01A-2henA:
24.5		 4v01A-2henA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
MET A 290
ILE A 293
LEU A 354
HIS A 361
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 1.06A 4v01A-2hz0A:
30.3		 4v01A-2hz0A:
40.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ALA A 452
GLU A 471
MET A 475
LEU A 537
HIS A 544
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
None
 0.68A 4v01A-2j0jA:
32.2		 4v01A-2j0jA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
GLU A 288
MET A 292
HIS A 362
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.58A 4v01A-2og8A:
31.3		 4v01A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 614
GLU A 633
MET A 637
LEU A 769
HIS A 776
ASP A 796
 None
 0.82A 4v01A-2ogvA:
32.9		 4v01A-2ogvA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
ALA A 905
LEU A 955
HIS A 962
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-3.6A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.55A 4v01A-2p4iA:
27.1		 4v01A-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 905
LEU A 955
HIS A 962
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.6A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 1.36A 4v01A-2p4iA:
27.1		 4v01A-2p4iA:
42.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 515
GLU A 534
MET A 537
MET A 538
ILE A 541
VAL A 564
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 None
 0.65A 4v01A-2psqA:
35.8		 4v01A-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		6 ALA A 218
GLU A 230
VAL A 285
ALA A 220
LEU A 189
ASP A 226
 None
 1.18A 4v01A-2vk4A:
undetectable		 4v01A-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
GLU A  66
LEU A 131
HIS A 138
ALA A 157
 J60  A1294 (-3.3A)
None
None
None
J60  A1294 ( 4.2A)
 0.60A 4v01A-2xikA:
19.3		 4v01A-2xikA:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 651
MET A 674
LEU A 737
HIS A 744
ASP A 764
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.9A)
None
None
None
 0.78A 4v01A-2xyuA:
27.0		 4v01A-2xyuA:
33.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 515
GLU A 534
MET A 537
MET A 538
ILE A 541
VAL A 564
ALA A 567
LEU A 617
 M33  A1996 (-3.3A)
None
None
None
None
None
M33  A1996 (-3.8A)
None
 0.89A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 515
MET A 537
MET A 538
ILE A 541
VAL A 564
ALA A 567
LEU A 617
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
None
M33  A1996 (-3.8A)
None
None
 0.72A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 515
MET A 538
ILE A 541
VAL A 564
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
None
 0.65A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  40
GLU A  64
ILE A  71
LEU A 130
HIS A 137
 4RB  A 401 (-3.3A)
GOL  A 503 (-2.8A)
None
None
None
 0.83A 4v01A-3bqrA:
20.2		 4v01A-3bqrA:
25.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A1108
GLU A1127
MET A1131
LEU A1195
HIS A1202
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.86A 4v01A-3c1xA:
27.5		 4v01A-3c1xA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
MET A 534
MET A 535
ILE A 538
VAL A 561
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-3.6A)
 0.60A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
GLU A 531
MET A 535
ILE A 538
ALA A 564
LEU A 614
HIS A 621
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.75A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 220
GLU A 236
MET A 240
LEU A 305
HIS A 312
 None
 0.72A 4v01A-3d7uA:
25.9		 4v01A-3d7uA:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 663
GLU A 682
MET A 686
LEU A 749
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.70A 4v01A-3dkoA:
32.1		 4v01A-3dkoA:
33.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 859
GLU A 878
ILE A 885
VAL A 909
LEU A1013
HIS A1020
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.8A)
None
 0.71A 4v01A-3hngA:
34.2		 4v01A-3hngA:
47.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 859
GLU A 878
VAL A 909
HIS A1020
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 ( 4.8A)
None
8ST  A2001 ( 3.7A)
 0.86A 4v01A-3hngA:
34.2		 4v01A-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  80
MET A 104
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 0.95A 4v01A-3iecA:
22.5		 4v01A-3iecA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLU A 100
MET A 104
ALA A 132
HIS A 173
ALA A 192
ASP A 193
 None
 1.22A 4v01A-3iecA:
22.5		 4v01A-3iecA:
27.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
GLU A 684
MET A 688
LEU A 751
HIS A 758
 None
 0.62A 4v01A-3kulA:
26.5		 4v01A-3kulA:
34.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ALA A 579
GLU A 596
ILE A 603
LEU A 668
HIS A 675
 ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.82A 4v01A-3lltA:
20.5		 4v01A-3lltA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.85A 4v01A-3lm5A:
23.3		 4v01A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnp AMIDOHYDROLASE
FAMILY PROTEIN
OLEI01672_1_465

(Oleispira
antarctica) 		PF01979
(Amidohydro_1) 		5 ILE A 165
ALA A 378
ALA A 147
ASP A 148
PHE A 170
 None
 0.75A 4v01A-3lnpA:
undetectable		 4v01A-3lnpA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ALA A 229
GLU A 244
LEU A 315
HIS A 330
ALA A 349
 LDN  A   1 (-3.6A)
None
None
None
LDN  A   1 ( 3.8A)
 0.83A 4v01A-3mdyA:
24.9		 4v01A-3mdyA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
MET A 134
ALA A 162
HIS A 203
ASP A 223
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
JOZ  A 361 (-3.8A)
None
SO4  A   5 ( 4.5A)
 0.94A 4v01A-3nuuA:
22.9		 4v01A-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 109
GLU A 130
MET A 134
ALA A 162
LEU A 196
HIS A 203
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
JOZ  A 361 (-3.8A)
None
None
 0.74A 4v01A-3nuuA:
22.9		 4v01A-3nuuA:
26.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
GLU A 596
MET A 600
LEU A 665
HIS A 674
 STU  A   1 (-3.3A)
None
None
None
None
 0.66A 4v01A-3ppzA:
27.9		 4v01A-3ppzA:
31.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLU A 107
MET A 111
ILE A 112
ALA A 132
LEU A  92
 None
 0.86A 4v01A-3q98A:
undetectable		 4v01A-3q98A:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 512
GLU A 531
MET A 534
MET A 535
ILE A 538
VAL A 561
ALA A 564
LEU A 614
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
None
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
None
 0.62A 4v01A-3tt0A:
39.7		 4v01A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
GLU A 531
MET A 535
ILE A 538
VAL A 561
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
None
None
07J  A   1 (-3.2A)
 0.48A 4v01A-3tt0A:
39.7		 4v01A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
GLU A 588
LEU A 670
HIS A 677
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.1A)
 0.93A 4v01A-3v5qA:
32.7		 4v01A-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
None
None
 0.46A 4v01A-3vidA:
34.7		 4v01A-3vidA:
49.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
HIS A1026
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 ( 4.6A)
None
None
 0.44A 4v01A-3wzdA:
26.5		 4v01A-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
None
 0.59A 4v01A-4agdA:
34.8		 4v01A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
ILE A 892
VAL A 916
LEU A1019
HIS A1026
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
None
 0.72A 4v01A-4agdA:
34.8		 4v01A-4agdA:
49.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  63
GLU A  81
LEU A 148
HIS A 155
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
None
XZN  A1317 ( 4.3A)
 0.85A 4v01A-4bc6A:
20.8		 4v01A-4bc6A:
28.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cag POLYSACCHARIDE LYASE
FAMILY 11 PROTEIN

(Bacillus
licheniformis) 		PF01839
(FG-GAP) 		5 ALA A 559
ILE A 173
ALA A 277
ALA A 202
PHE A 193
 None
 0.84A 4v01A-4cagA:
undetectable		 4v01A-4cagA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 653
GLU A 672
MET A 676
LEU A 757
HIS A 764
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.88A 4v01A-4ckrA:
30.8		 4v01A-4ckrA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 684
GLU A 705
ALA A 740
LEU A 773
ALA A 799
 AGS  A1985 (-3.5A)
None
AGS  A1985 (-3.9A)
None
AGS  A1985 ( 4.5A)
 0.75A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 GLU A 845
ILE A 849
ALA A1023
HIS A 921
ASP A 842
 None
 0.83A 4v01A-4ddwA:
undetectable		 4v01A-4ddwA:
15.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 400
GLU A 420
ALA A 451
LEU A 485
HIS A 492
 0SB  A 701 (-3.3A)
None
0SB  A 701 (-4.0A)
None
None
 0.84A 4v01A-4f4pA:
29.1		 4v01A-4f4pA:
36.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 400
GLU A 420
MET A 424
ALA A 451
LEU A 485
 0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.0A)
None
 0.87A 4v01A-4f4pA:
29.1		 4v01A-4f4pA:
36.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
GLU A  71
VAL A 100
LEU A 137
HIS A 144
 STU  A 401 (-3.2A)
None
None
None
None
 0.81A 4v01A-4fr4A:
20.3		 4v01A-4fr4A:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 853
GLU A 871
LEU A 940
HIS A 947
ALA A 966
 19S  A1201 (-3.3A)
None
None
None
19S  A1201 ( 4.1A)
 0.64A 4v01A-4hviA:
29.5		 4v01A-4hviA:
35.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i86 CELLULOSE SYNTHASE 1

(Komagataeibacter
xylinus) 		PF07238
(PilZ) 		6 GLU A  30
ILE A  12
ALA A  68
LEU A 100
ALA A  37
ASP A  31
 None
 1.35A 4v01A-4i86A:
undetectable		 4v01A-4i86A:
16.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 156
GLU A 177
ALA A 208
LEU A 243
HIS A 250
 1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.8A)
None
None
 0.72A 4v01A-4id7A:
22.9		 4v01A-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 506
GLU A 525
MET A 528
MET A 529
ILE A 532
VAL A 555
ALA A 558
LEU A 608
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
 0.69A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 506
GLU A 525
MET A 529
ILE A 532
VAL A 555
ALA A 558
LEU A 608
HIS A 615
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
None
 0.69A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 506
MET A 529
ILE A 532
VAL A 555
ALA A 558
HIS A 615
ALA A 634
ASP A 635
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
MG  A 802 ( 3.0A)
 0.99A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		6 ALA A 147
MET A 256
VAL A 149
HIS A 121
ALA A 182
ASP A 183
 None
 1.32A 4v01A-4koaA:
undetectable		 4v01A-4koaA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A  61
GLU A  77
ALA A 107
LEU A 144
HIS A 154
 1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
None
None
 0.84A 4v01A-4l52A:
20.9		 4v01A-4l52A:
30.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  54
GLU A  70
MET A  74
LEU A 137
HIS A 144
ALA A 163
 GOL  A 404 ( 3.1A)
None
None
None
None
GOL  A 403 ( 3.0A)
 0.89A 4v01A-4lg4A:
18.0		 4v01A-4lg4A:
27.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA B  51
GLU B  70
LEU B 135
HIS B 142
ALA B 161
 ADP  B 500 (-3.3A)
None
None
None
None
 0.60A 4v01A-4o27B:
18.6		 4v01A-4o27B:
28.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2z MITOGEN-ACTIVATED
PROTEIN KINASE 3,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		6 GLU A  94
MET A  97
MET A  98
LEU A 166
HIS A 173
ASP A 193
 046  A 401 (-3.7A)
046  A 401 (-3.9A)
046  A 401 (-3.5A)
None
046  A 401 (-4.1A)
046  A 401 (-4.3A)
 0.77A 4v01A-4o2zA:
21.3		 4v01A-4o2zA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA B 390
VAL B 434
LEU B 475
HIS B 483
ALA B 502
 ACP  B 801 (-3.2A)
ACP  B 801 (-4.8A)
None
None
None
 0.82A 4v01A-4oavB:
17.2		 4v01A-4oavB:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.5A)
None
P30  A1001 ( 4.3A)
None
 0.69A 4v01A-4rt7A:
26.5		 4v01A-4rt7A:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 442
HIS A 449
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.46A 4v01A-4tptA:
21.4		 4v01A-4tptA:
27.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 ALA A  35
GLU A  52
MET A  56
LEU A 120
HIS A 127
ALA A 146
 ACP  A1264 (-2.9A)
None
None
None
None
None
 1.07A 4v01A-4ueuA:
30.1		 4v01A-4ueuA:
41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd2 AROMATIC-AMINO-ACID
TRANSAMINASE TYRB

(Burkholderia
cenocepacia) 		PF00155
(Aminotran_1_2) 		6 ILE A 325
VAL A  29
LEU A 329
HIS A 332
ALA A 391
ASP A 390
 None
GOL  A 500 (-3.8A)
None
None
None
None
 1.16A 4v01A-4wd2A:
undetectable		 4v01A-4wd2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  72
GLU A  90
MET A  94
LEU A 165
HIS A 174
 KSA  A 405 (-3.2A)
None
None
None
None
 0.85A 4v01A-4wsqA:
21.7		 4v01A-4wsqA:
25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 501
GLU A 520
MET A 524
ILE A 527
VAL A 550
ALA A 553
LEU A 603
HIS A 610
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-3.0A)
 0.45A 4v01A-4xcuA:
37.9		 4v01A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 ALA B 288
MET B 309
ILE B 312
LEU B 373
HIS B 380
ALA B 399
 1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
None
None
1N1  B 601 (-3.5A)
 0.92A 4v01A-4xeyB:
31.2		 4v01A-4xeyB:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
GLU A 661
MET A 664
LEU A 802
HIS A 809
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-3.9A)
None
P30  A1001 (-4.4A)
None
P30  A1001 ( 4.1A)
 0.78A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
MET A 664
MET A 665
LEU A 802
HIS A 809
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.9A)
P30  A1001 (-4.4A)
None
P30  A1001 (-4.4A)
None
 0.87A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 488
GLU A 509
LEU A 577
HIS A 586
ALA A 605
 4CV  A 801 (-3.5A)
None
None
None
4CV  A 801 ( 3.9A)
 0.86A 4v01A-4yffA:
24.6		 4v01A-4yffA:
28.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
MET A 534
MET A 535
ILE A 538
VAL A 561
ALA A 564
LEU A 614
HIS A 621
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
EDO  A1766 ( 4.4A)
 0.52A 4v01A-5a46A:
42.1		 4v01A-5a46A:
98.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 ALA A  83
GLU A 103
ALA A 135
HIS A 176
ALA A 195
 5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
5RC  A4000 ( 3.9A)
 0.82A 4v01A-5es1A:
22.5		 4v01A-5es1A:
28.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
None
 0.61A 4v01A-5fm2A:
33.7		 4v01A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 625
GLU A 644
HIS A 816
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.85A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 625
GLU A 644
MET A 648
LEU A 809
HIS A 816
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.6A)
748  A1001 (-3.8A)
748  A1001 (-4.8A)
 0.51A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
MET A1131
LEU A1195
HIS A1202
ALA A1221
 63K  A1401 (-3.5A)
None
None
None
63K  A1401 (-3.3A)
 0.61A 4v01A-5horA:
27.3		 4v01A-5horA:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.54A 4v01A-5idnA:
13.7		 4v01A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
MET A  64
MET A  65
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 ( 4.2A)
 0.84A 4v01A-5j5tA:
21.2		 4v01A-5j5tA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
MET A  65
LEU A 127
HIS A 134
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
None
6G2  A 901 ( 4.2A)
 0.80A 4v01A-5j5tA:
21.2		 4v01A-5j5tA:
24.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 663
MET A 686
LEU A 749
HIS A 756
ASP A 776
 6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
None
DIO  A1002 (-4.1A)
None
 0.78A 4v01A-5l6oA:
32.0		 4v01A-5l6oA:
31.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 119
GLU A 136
LEU A 215
HIS A 223
ALA A 540
 W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
None
DMS  A 717 ( 4.5A)
 0.71A 4v01A-5myvA:
19.2		 4v01A-5myvA:
24.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 617
MET A 641
LEU A 714
HIS A 721
ALA A 740
 7AE  A1000 (-3.3A)
None
None
None
7AE  A1000 ( 3.7A)
 0.71A 4v01A-5td2A:
29.6		 4v01A-5td2A:
41.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  42
GLU A  61
MET A  65
LEU A 135
HIS A 142
 None
 0.80A 4v01A-5tqwA:
14.3		 4v01A-5tqwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 107
GLU A 124
LEU A 203
HIS A 211
ALA A 496
 EMH  A 705 (-3.6A)
None
None
None
EMH  A 705 ( 4.0A)
 0.58A 4v01A-5xv7A:
20.1		 4v01A-5xv7A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 ALA A  87
GLU A 107
MET A 111
ALA A 139
HIS A 180
ALA A 199
 None
 0.77A 4v01A-6c9dA:
21.2		 4v01A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
GLU A 236
LEU A 303
HIS A 310
ALA A 329
 F6J  A 501 (-3.4A)
F6J  A 501 ( 4.7A)
None
None
F6J  A 501 ( 4.0A)
 0.84A 4v01A-6cmjA:
21.9		 4v01A-6cmjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 ALA A 715
GLU A 732
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.50A 4v01A-6cnhA:
21.7		 4v01A-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 5 GLU A 732
LEU A 806
HIS A 813
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.62A 4v01A-6cnhA:
21.7		 4v01A-6cnhA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 5 ALA A 756
VAL A 804
ALA A 807
LEU A 865
HIS A 872
 ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
None
 0.57A 4v01A-6fekA:
32.6		 4v01A-6fekA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 588
LYS A 608
TYR A 656
ARG A 723
LEU A 731
ILE A 740
 None
 1.03A 4v01A-1lufA:
34.0		 4v01A-1lufA:
38.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
TYR A 693
CYH A 807
LEU A 818
ILE A 827
 None
 0.40A 4v01A-1rjbA:
33.1		 4v01A-1rjbA:
45.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
LYS A 623
TYR A 672
ARG A 791
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 ( 4.0A)
None
STI  A   3 (-4.4A)
 1.07A 4v01A-1t46A:
26.9		 4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
VAL A 603
TYR A 672
CYH A 788
ARG A 791
LEU A 799
ILE A 808
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 ( 4.0A)
STI  A   3 (-2.8A)
None
STI  A   3 (-4.4A)
None
 0.86A 4v01A-1t46A:
26.9		 4v01A-1t46A:
48.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
VAL A 352
LYS A 369
LEU A 468
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-4.5A)
None
 0.47A 4v01A-1u59A:
30.3		 4v01A-1u59A:
35.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
LYS A  57
ILE A  89
TYR A 107
ARG A 150
LEU A 158
 None
None
None
None
SEP  A 181 ( 2.8A)
None
 0.73A 4v01A-1u5qA:
23.6		 4v01A-1u5qA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
TYR A  86
ARG A 129
LEU A 137
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
HYM  A 400 (-4.5A)
None
 0.55A 4v01A-1zltA:
21.1		 4v01A-1zltA:
28.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
VAL X  25
TYR X  84
LEU X 137
ILE X 146
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
None
 0.35A 4v01A-2dq7X:
30.3		 4v01A-2dq7X:
37.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 VAL A  42
LYS A  57
ILE A  89
TYR A 107
ARG A 150
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 ( 4.5A)
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
SEP  A 181 ( 2.9A)
STU  A 400 ( 4.6A)
 0.69A 4v01A-2gcdA:
24.5		 4v01A-2gcdA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  55
VAL A  63
LYS A  78
ARG A 169
LEU A 177
ILE A 189
 None
 1.05A 4v01A-2hw6A:
19.5		 4v01A-2hw6A:
25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
 0.72A 4v01A-2i0eA:
13.1		 4v01A-2i0eA:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
LYS A 273
ARG A 363
LEU A 371
ILE A 380
 None
None
1N8  A 501 ( 3.4A)
None
1N8  A 501 ( 4.3A)
None
 1.47A 4v01A-2og8A:
31.3		 4v01A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 251
VAL A 259
TYR A 318
ARG A 363
LEU A 371
ILE A 380
 None
None
1N8  A 501 ( 3.7A)
None
1N8  A 501 ( 4.3A)
None
 1.16A 4v01A-2og8A:
31.3		 4v01A-2og8A:
38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
TYR A 665
CYH A 774
ARG A 777
LEU A 785
ILE A 794
 None
 0.87A 4v01A-2ogvA:
32.9		 4v01A-2ogvA:
47.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 838
LYS A 855
ILE A 886
TYR A 904
LEU A 971
ILE A 980
 MR9  A 301 (-4.6A)
MR9  A 301 ( 4.6A)
MR9  A 301 (-4.0A)
MR9  A 301 (-3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.6A)
 1.03A 4v01A-2p4iA:
27.1		 4v01A-2p4iA:
42.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
LYS A  48
ILE A  87
ARG A 148
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
ATP  A 381 ( 4.8A)
 1.05A 4v01A-2phkA:
21.6		 4v01A-2phkA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
ILE A 548
TYR A 566
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
None
 0.92A 4v01A-2psqA:
35.8		 4v01A-2psqA:
73.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU C  55
VAL C  63
LYS C  78
ILE C 111
TYR C 131
LEU C 183
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
None
 0.73A 4v01A-2wtkC:
22.3		 4v01A-2wtkC:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
ILE A 548
TYR A 566
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
M33  A1996 ( 4.7A)
None
None
M33  A1996 (-4.5A)
None
 0.97A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 517
ILE A 548
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 M33  A1996 ( 4.5A)
None
None
None
M33  A1996 (-4.5A)
None
 1.21A 4v01A-3b2tA:
26.7		 4v01A-3b2tA:
86.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
None
 0.71A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
CYH A 619
LEU A 630
 C4F  A   1 ( 3.9A)
None
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.86A 4v01A-3c4fA:
41.8		 4v01A-3c4fA:
99.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
ILE A  62
 DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
None
 1.17A 4v01A-3eb0A:
20.3		 4v01A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LYS A  38
ILE A  63
TYR A 119
LEU A 173
 DRK  A 384 (-3.8A)
None
None
DRK  A 384 ( 4.5A)
DRK  A 384 (-4.4A)
DRK  A 384 (-4.4A)
 0.80A 4v01A-3eb0A:
20.3		 4v01A-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		6 VAL A  29
ILE A  75
CYH A 132
ARG A 135
LEU A 143
ILE A 157
 None
 0.92A 4v01A-3gbzA:
16.6		 4v01A-3gbzA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		6 VAL A  29
ILE A  75
TYR A  93
ARG A 135
LEU A 143
ILE A 157
 None
 0.94A 4v01A-3gbzA:
16.6		 4v01A-3gbzA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 833
VAL A 841
TYR A 911
ARG A1021
LEU A1029
ILE A1038
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.9A)
None
None
None
 0.79A 4v01A-3hngA:
34.2		 4v01A-3hngA:
47.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		6 LEU A 226
VAL A 234
ILE A 286
ARG A 346
LEU A 354
ILE A 366
 None
 1.26A 4v01A-3i6uA:
20.6		 4v01A-3i6uA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 680
VAL A 689
ILE A 729
ARG A 796
LEU A 804
ILE A 826
 ADP  A2101 ( 4.1A)
ADP  A2101 (-4.5A)
None
TPO  A 844 ( 3.0A)
ADP  A2101 (-4.4A)
None
 0.76A 4v01A-3lj0A:
21.6		 4v01A-3lj0A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  39
VAL A  47
LYS A  62
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.79A 4v01A-3lm5A:
23.3		 4v01A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  61
VAL A  69
ILE A 116
TYR A 134
LEU A 184
ILE A 193
 None
 0.97A 4v01A-3mn3A:
20.7		 4v01A-3mn3A:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
VAL A  57
LYS A  72
TYR A 122
ARG A 165
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
None
None
TPO  A 197 ( 3.1A)
XFE  A 351 (-4.6A)
 0.92A 4v01A-3mvjA:
20.2		 4v01A-3mvjA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
VAL A  96
TYR A 161
ARG A 204
LEU A 212
ILE A 221
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
None
SEP  A 241 ( 3.4A)
None
None
 0.78A 4v01A-3nuuA:
22.9		 4v01A-3nuuA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
LYS A 371
TYR A 422
ARG A 465
ILE A 482
 ANP  A 800 ( 4.4A)
ANP  A 800 ( 4.7A)
ANP  A 800 (-3.3A)
ANP  A 800 (-4.2A)
TPO  A 500 ( 2.9A)
None
 0.99A 4v01A-3pfqA:
19.0		 4v01A-3pfqA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
LEU A 630
ILE A 544
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
None
 1.36A 4v01A-3tt0A:
39.7		 4v01A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
LYS A 514
ILE A 545
TYR A 563
LEU A 630
ILE A 639
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
None
 0.47A 4v01A-3tt0A:
39.7		 4v01A-3tt0A:
92.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 544
VAL A 552
LYS A 572
TYR A 619
LEU A 686
ILE A 695
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.0A)
0F4  A 902 (-4.2A)
0F4  A 902 (-4.5A)
0F4  A 902 (-4.6A)
 0.67A 4v01A-3v5qA:
32.7		 4v01A-3v5qA:
38.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
LYS A 868
CYH A1024
ARG A1027
LEU A1035
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
None
4TT  A2001 (-4.8A)
None
 0.58A 4v01A-3vidA:
34.7		 4v01A-3vidA:
49.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
VAL A 147
LYS A 162
TYR A 212
LEU A 263
ILE A 272
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 (-4.4A)
N13  A 501 (-4.5A)
None
 0.66A 4v01A-3w18A:
22.3		 4v01A-3w18A:
28.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
ARG A1027
LEU A1035
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
LEV  A1201 (-4.8A)
None
 0.93A 4v01A-3wzdA:
26.5		 4v01A-3wzdA:
54.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
LYS A 868
CYH A1024
ARG A1027
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
 1.08A 4v01A-3wzdA:
26.5		 4v01A-3wzdA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  83
VAL A  91
TYR A 156
LEU A 207
ILE A 216
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-4.2A)
VX6  A 500 (-4.6A)
None
 0.43A 4v01A-4af3A:
19.8		 4v01A-4af3A:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
CYH A1024
LEU A1035
ILE A1044
 B49  A2000 (-3.7A)
None
None
B49  A2000 (-4.5A)
None
 0.50A 4v01A-4agdA:
34.8		 4v01A-4agdA:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 560
VAL A 568
LYS A 588
TYR A 635
ARG A 691
LEU A 699
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-4.2A)
None
 0.71A 4v01A-4at3A:
31.0		 4v01A-4at3A:
37.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 LEU A 246
VAL A 254
LYS A 269
ILE A 302
TYR A 320
ARG A 363
LEU A 371
ILE A 380
 None
 0.86A 4v01A-4c0tA:
22.4		 4v01A-4c0tA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 LEU A 246
VAL A 254
LYS A 269
TYR A 320
LEU A 371
ILE A 370
 None
 1.22A 4v01A-4c0tA:
22.4		 4v01A-4c0tA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A1550 (-4.3A)
None
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
None
 0.84A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
STU  A1550 (-4.3A)
 0.93A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ILE A  76
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.6A)
STU  A1550 ( 4.3A)
STU  A1550 (-4.5A)
None
 1.21A 4v01A-4cfhA:
22.8		 4v01A-4cfhA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
LYS A 655
ILE A 685
TYR A 703
ARG A 765
LEU A 773
ILE A 782
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
 1.31A 4v01A-4ckrA:
30.8		 4v01A-4ckrA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
LYS A 686
TYR A 739
ARG A 781
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
 0.79A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
TYR A 739
ARG A 781
LEU A 789
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
TPO  A 816 ( 3.0A)
AGS  A1985 (-4.8A)
None
 0.48A 4v01A-4crsA:
16.1		 4v01A-4crsA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		6 LEU A  16
VAL A  24
TYR A  89
ARG A 132
LEU A 140
ILE A 149
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.7A)
ANP  A 300 (-4.3A)
None
ANP  A 300 (-4.7A)
None
 1.01A 4v01A-4eqmA:
21.8		 4v01A-4eqmA:
24.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
VAL A 523
LYS A 543
TYR A 590
ARG A 648
LEU A 656
ILE A 665
 None
 0.88A 4v01A-4f0iA:
26.5		 4v01A-4f0iA:
38.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
VAL A 863
LYS A 882
TYR A 931
LEU A 983
ILE A 992
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
None
IZA  A2001 ( 4.7A)
None
 0.63A 4v01A-4gl9A:
27.8		 4v01A-4gl9A:
35.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
LYS A 855
TYR A 904
LEU A 956
ILE A 883
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
None
 1.13A 4v01A-4hviA:
29.5		 4v01A-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
LYS A 855
TYR A 904
LEU A 956
ILE A 965
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
19S  A1201 (-4.7A)
19S  A1201 (-4.5A)
None
 0.63A 4v01A-4hviA:
29.5		 4v01A-4hviA:
35.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		7 LEU A 132
VAL A 140
LYS A 158
ILE A 190
ARG A 251
LEU A 259
ILE A 268
 None
 1.08A 4v01A-4hzsA:
27.5		 4v01A-4hzsA:
33.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 132
VAL A 140
ILE A 190
LEU A 259
ILE A 268
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-4.3A)
1G0  A 401 (-4.6A)
None
 0.49A 4v01A-4id7A:
12.9		 4v01A-4id7A:
37.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
ILE A 539
TYR A 557
ARG A 616
LEU A 624
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
None
None
None
ACP  A 801 (-4.4A)
None
 0.80A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
ILE A 539
TYR A 557
CYH A 613
LEU A 624
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
None
None
None
ACP  A 801 (-4.4A)
None
 0.48A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
LYS A 508
ILE A 539
TYR A 557
ARG A 616
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
None
None
None
 0.96A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
LYS A 508
ILE A 539
TYR A 557
CYH A 613
ILE A 538
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
None
None
None
 1.37A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
LYS A 508
ILE A 539
TYR A 557
CYH A 613
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
None
None
None
 0.69A 4v01A-4k33A:
27.0		 4v01A-4k33A:
80.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A 959
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 1.22A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
LYS A 930
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-4.4A)
None
 0.71A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A 930
ILE A 960
TYR A 980
ARG A1022
LEU A1030
ILE A1039
 None
None
2TT  A1202 (-4.6A)
None
2TT  A1202 (-4.4A)
None
 1.16A 4v01A-4oliA:
27.4		 4v01A-4oliA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
LYS A 650
TYR A 703
ARG A 745
LEU A 753
 None
None
None
None
TPO  A 780 ( 2.8A)
None
 0.96A 4v01A-4otdA:
21.2		 4v01A-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
TYR A 703
ARG A 745
LEU A 753
ILE A 762
 None
None
None
TPO  A 780 ( 2.8A)
None
None
 0.69A 4v01A-4otdA:
21.2		 4v01A-4otdA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  24
VAL A  32
ILE A  79
TYR A  97
ARG A 140
LEU A 148
ILE A 157
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
None
 0.93A 4v01A-4rewA:
22.4		 4v01A-4rewA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  24
VAL A  32
LYS A  47
ILE A  79
TYR A  97
ARG A 140
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 ( 4.6A)
STU  A 601 (-4.4A)
None
STU  A 601 (-4.2A)
 0.95A 4v01A-4rewA:
22.4		 4v01A-4rewA:
18.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
LYS A 644
TYR A 693
CYH A 807
LEU A 818
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
None
P30  A1001 (-4.6A)
 0.68A 4v01A-4rt7A:
26.5		 4v01A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
TYR A 693
CYH A 807
LEU A 818
ILE A 827
 P30  A1001 (-3.8A)
None
P30  A1001 (-4.1A)
None
P30  A1001 (-4.6A)
P30  A1001 ( 4.8A)
 0.34A 4v01A-4rt7A:
26.5		 4v01A-4rt7A:
40.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
LYS A  37
TYR A  83
ARG A 128
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.8A)
 0.96A 4v01A-4ueuA:
30.1		 4v01A-4ueuA:
41.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
VAL A 112
LYS A 127
TYR A 177
ARG A 220
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
TPO  A 252 ( 2.9A)
ATP  A 501 (-4.5A)
 0.86A 4v01A-4wb7A:
20.2		 4v01A-4wb7A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
LYS A 216
ARG A 313
LEU A 321
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
ANW  A 601 (-4.9A)
None
 0.88A 4v01A-4wboA:
22.1		 4v01A-4wboA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
VAL A 481
ILE A 534
ARG A 611
LEU A 619
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
None
40M  A1002 (-4.5A)
None
 0.78A 4v01A-4xcuA:
37.9		 4v01A-4xcuA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
LYS A 644
TYR A 693
ARG A 810
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 1.27A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
LYS A 644
TYR A 693
CYH A 807
LEU A 818
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.58A 4v01A-4xufA:
33.3		 4v01A-4xufA:
49.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7g SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 LEU A 577
VAL A 586
ILE A 626
ARG A 687
LEU A 695
ILE A 709
 None
 0.92A 4v01A-4z7gA:
19.6		 4v01A-4z7gA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ILE A 545
TYR A 563
ARG A 622
LEU A 630
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
38O  A1769 (-4.6A)
None
 0.50A 4v01A-5a46A:
42.1		 4v01A-5a46A:
98.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
ILE A 545
TYR A 563
CYH A 619
ARG A 622
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
None
None
None
 0.88A 4v01A-5a46A:
42.1		 4v01A-5a46A:
98.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  30
TYR A  94
ARG A 137
LEU A 145
ILE A 163
 51W  A 401 ( 4.3A)
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
51W  A 401 (-4.5A)
None
 0.47A 4v01A-5ci7A:
17.5		 4v01A-5ci7A:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ILE A 960
TYR A 980
LEU A1030
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
None
 0.61A 4v01A-5f1zA:
28.5		 4v01A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
VAL A 911
LYS A 930
TYR A 980
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
 0.50A 4v01A-5f1zA:
28.5		 4v01A-5f1zA:
35.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
None
None
SEP  A 909 ( 3.0A)
PP1  A2012 (-4.6A)
None
 0.94A 4v01A-5fm2A:
33.7		 4v01A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 730
VAL A 738
LYS A 758
ILE A 788
TYR A 806
ARG A 873
ILE A 890
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
None
None
SEP  A 909 ( 3.0A)
None
 1.08A 4v01A-5fm2A:
33.7		 4v01A-5fm2A:
51.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
TYR A 676
CYH A 814
ARG A 817
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 (-4.0A)
748  A1001 (-3.4A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.81A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
VAL A 607
LYS A 627
TYR A 676
ARG A 817
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
 0.98A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
VAL A 607
TYR A 676
ARG A 817
LEU A 825
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
None
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.71A 4v01A-5grnA:
27.1		 4v01A-5grnA:
46.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  57
VAL A  65
LYS A  79
TYR A 132
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.39A 4v01A-5i3oA:
21.7		 4v01A-5i3oA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  35
ILE A  79
TYR A  99
ARG A 150
LEU A 158
ILE A 171
 6A7  A 401 ( 4.5A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
None
6A7  A 401 (-4.8A)
None
 0.76A 4v01A-5idnA:
13.7		 4v01A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 VAL A  32
LYS A  47
TYR A  96
ARG A 139
LEU A 147
ILE A 159
 None
None
PO4  A 401 (-4.8A)
None
None
None
 1.29A 4v01A-5ig1A:
23.2		 4v01A-5ig1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
ILE A  77
TYR A  95
ARG A 138
LEU A 146
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
None
 1.02A 4v01A-5isoA:
22.6		 4v01A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 LEU A  22
VAL A  30
LYS A  45
ILE A  77
TYR A  95
ARG A 138
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.3A)
None
STU  A 601 (-4.5A)
 1.21A 4v01A-5isoA:
22.6		 4v01A-5isoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
VAL A  32
TYR A  97
LEU A 153
ILE A 162
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
None
9WS  A 401 (-4.6A)
None
 0.47A 4v01A-5w5jA:
23.8		 4v01A-5w5jA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
LYS A 919
TYR A 965
LEU A1017
ILE A1026
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
None
 0.82A 4v01A-5wnoA:
27.9		 4v01A-5wnoA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 6 VAL A  74
LYS A  89
TYR A 138
ARG A 181
LEU A 189
ILE A 198
 None
 0.88A 4v01A-6c9dA:
21.2		 4v01A-6c9dA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 VAL A 200
LYS A 213
TYR A 264
ARG A 310
LEU A 318
ILE A 327
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
TPO  A 345 ( 4.9A)
CJT  A 502 (-4.7A)
None
 0.69A 4v01A-6f3dA:
22.7		 4v01A-6f3dA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 7 LEU A 730
VAL A 738
ILE A 788
TYR A 806
ARG A 873
LEU A 881
ILE A 890
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 ( 4.1A)
FMT  A1101 (-2.8A)
ADN  A1104 (-4.3A)
None
 0.98A 4v01A-6fekA:
32.6		 4v01A-6fekA:
18.64