SIMILAR PATTERNS OF AMINO ACIDS FOR 4UYM_A_VORA590

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cs3 ZINC FINGER PROTEIN
PLZF

(Homo sapiens) 		PF00651
(BTB) 		4 PHE A  63
ILE A  83
LEU A  72
PHE A  80
 None
 1.04A 4uymA-1cs3A:
0.0		 4uymA-1cs3A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 104
SER A   4
ILE A 275
LEU A 258
 None
 1.00A 4uymA-1dm3A:
0.0		 4uymA-1dm3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 TYR A 446
ALA A 469
LEU A 100
PHE A 101
 None
 1.05A 4uymA-1eyyA:
0.0		 4uymA-1eyyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqp RFCS

(Pyrococcus
furiosus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 TYR A  40
ALA A  62
LEU A  49
PHE A  51
 None
 0.76A 4uymA-1iqpA:
0.0		 4uymA-1iqpA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1p TRIGGER FACTOR

(Escherichia
coli) 		PF00254
(FKBP_C) 		4 PHE A  74
ILE A  92
LEU A  44
PHE A  42
 None
 1.00A 4uymA-1l1pA:
0.0		 4uymA-1l1pA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		4 TYR A 336
PHE A  36
ALA A  44
LEU A 363
 None
 0.92A 4uymA-1oltA:
0.0		 4uymA-1oltA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 107
ILE A 113
LEU A 283
PHE A 284
 None
 1.09A 4uymA-1qorA:
0.0		 4uymA-1qorA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		4 ALA A  53
ILE A 122
LEU A 187
PHE A 175
 None
 1.01A 4uymA-1r44A:
0.0		 4uymA-1r44A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		4 PHE A  10
ALA A  84
ILE A 109
LEU A  91
 None
 0.87A 4uymA-1rptA:
0.0		 4uymA-1rptA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s12 HYPOTHETICAL PROTEIN
TM1457

(Thermotoga
maritima) 		PF04327
(Peptidase_Prp) 		4 ALA A  24
SER A  27
ILE A   2
LEU A  77
 None
 1.02A 4uymA-1s12A:
undetectable		 4uymA-1s12A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s62 TOLA PROTEIN

(Escherichia
coli) 		PF06519
(TolA) 		4 PHE A  98
ALA A  20
LEU A  48
PHE A  91
 None
 0.97A 4uymA-1s62A:
undetectable		 4uymA-1s62A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1up4 6-PHOSPHO-BETA-GLUCO
SIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ALA A 299
SER A 295
ILE A 166
LEU A 161
 None
 0.96A 4uymA-1up4A:
undetectable		 4uymA-1up4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y43 ASPERGILLOPEPSIN II
HEAVY CHAIN

(Aspergillus
niger) 		PF01828
(Peptidase_A4) 		4 TYR B  50
PHE B  52
ALA B  77
PHE B  92
 None
 1.08A 4uymA-1y43B:
undetectable		 4uymA-1y43B:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycd HYPOTHETICAL 27.3
KDA PROTEIN IN
AAP1-SMF2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF03959
(FSH1) 		4 PHE A  75
SER A 164
ILE A 157
PHE A 165
 None
 1.06A 4uymA-1ycdA:
undetectable		 4uymA-1ycdA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT

(Streptococcus
pyogenes) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A   4
ILE A  85
LEU A  77
PHE A  82
 None
 1.00A 4uymA-2avtA:
undetectable		 4uymA-2avtA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0n A197

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 ALA A  44
ILE A 123
LEU A 118
PHE A  59
 None
 1.01A 4uymA-2c0nA:
undetectable		 4uymA-2c0nA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnc MALTOSE ABC
TRANSPORTER,
PERIPLASMIC
MALTOSE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF13416
(SBP_bac_8) 		4 ALA A 289
ILE A  80
LEU A  86
PHE A  83
 None
 1.08A 4uymA-2fncA:
undetectable		 4uymA-2fncA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0j HYPOTHETICAL PROTEIN
SMU.848

(Streptococcus
mutans) 		PF04327
(Peptidase_Prp) 		4 ALA A  34
SER A  37
ILE A   2
LEU A  96
 None
 0.92A 4uymA-2g0jA:
undetectable		 4uymA-2g0jA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		4 PHE A  16
ILE A 165
LEU A  61
PHE A  63
 None
 1.01A 4uymA-2g5xA:
undetectable		 4uymA-2g5xA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpa PROTEIN (ACID
PHOSPHATASE)

(Homo sapiens) 		PF00328
(His_Phos_2) 		4 PHE A1010
ALA A1084
ILE A1109
LEU A1091
 None
 0.92A 4uymA-2hpaA:
undetectable		 4uymA-2hpaA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idl HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF04327
(Peptidase_Prp) 		4 ALA A  35
SER A  38
ILE A   2
LEU A  98
 None
 1.07A 4uymA-2idlA:
undetectable		 4uymA-2idlA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 ALA 1 508
ILE 1 404
LEU 1 557
PHE 1 556
 None
 1.06A 4uymA-2ijd1:
undetectable		 4uymA-2ijd1:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isa CATALASE

(Aliivibrio
salmonicida) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ALA A 466
ILE A 471
LEU A 437
PHE A 438
 None
 1.00A 4uymA-2isaA:
undetectable		 4uymA-2isaA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ALA X  88
SER X  92
ILE X 103
LEU X 424
 None
 0.82A 4uymA-2iv2X:
undetectable		 4uymA-2iv2X:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 ALA A 424
SER A 435
ILE A 437
LEU A 128
 None
 1.08A 4uymA-2j3mA:
undetectable		 4uymA-2j3mA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxv TELLURITE RESISTANCE
PROTEIN

(Klebsiella
pneumoniae) 		PF02342
(TerD) 		4 TYR A 125
ALA A 136
LEU A 127
PHE A 103
 None
 1.01A 4uymA-2kxvA:
undetectable		 4uymA-2kxvA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l1l CAMP-DEPENDENT
PROTEIN KINASE
INHIBITOR ALPHA
EXPORTIN-1

(Homo sapiens) 		no annotation 4 PHE B 572
ALA B 541
ILE B 521
LEU A  14
 None
 1.05A 4uymA-2l1lB:
undetectable		 4uymA-2l1lB:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Escherichia
coli) 		PF01507
(PAPS_reduct) 		4 PHE A  89
ALA A  58
SER A  61
ILE A 190
 None
 0.77A 4uymA-2o8vA:
undetectable		 4uymA-2o8vA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmi PBP RELATED
BETA-LACTAMASE

(Pyrococcus
abyssi) 		PF00144
(Beta-lactamase)
PF13969
(Pab87_oct) 		4 TYR A 312
ALA A 343
LEU A 299
PHE A 294
 None
 0.97A 4uymA-2qmiA:
undetectable		 4uymA-2qmiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		4 TYR A1055
ALA A1471
SER A1088
ILE A1102
 None
 0.99A 4uymA-2ri8A:
undetectable		 4uymA-2ri8A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ALA A 587
SER A 585
ILE A 590
LEU A 592
 None
 1.01A 4uymA-2xsgA:
undetectable		 4uymA-2xsgA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 PHE A  17
ALA A  30
LEU A 370
PHE A  21
 None
 1.05A 4uymA-2y0kA:
undetectable		 4uymA-2y0kA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		4 TYR A 415
PHE A 398
ALA A 432
LEU A 352
 None
 1.04A 4uymA-2ykyA:
undetectable		 4uymA-2ykyA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01336
(tRNA_anti-codon)
PF08489
(DUF1743) 		4 PHE A 307
ILE A 289
LEU A 314
PHE A 287
 None
 0.83A 4uymA-3au7A:
undetectable		 4uymA-3au7A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bgh PUTATIVE
NEURAMINYLLACTOSE-BI
NDING HEMAGGLUTININ
HOMOLOG

(Helicobacter
pylori) 		PF05211
(NLBH) 		4 ALA A 218
ILE A  67
LEU A  85
PHE A  81
 None
 0.90A 4uymA-3bghA:
undetectable		 4uymA-3bghA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 TYR A 161
ALA A  92
ILE A 195
LEU A 103
 None
 0.90A 4uymA-3bhwA:
undetectable		 4uymA-3bhwA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byw PUTATIVE
ARABINOFURANOSYLTRAN
SFERASE

(Corynebacterium
diphtheriae) 		PF04602
(Arabinose_trans) 		4 ALA A 188
ILE A 166
LEU A 100
PHE A  65
 None
 1.08A 4uymA-3bywA:
undetectable		 4uymA-3bywA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzw PUTATIVE LIPASE

(Bacteroides
thetaiotaomicron) 		PF13472
(Lipase_GDSL_2) 		4 PHE A 235
ALA A 271
ILE A  78
LEU A 278
 None
 0.92A 4uymA-3bzwA:
undetectable		 4uymA-3bzwA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 PHE A 429
ILE A 475
LEU A 454
PHE A 450
 None
 0.81A 4uymA-3ciaA:
1.2		 4uymA-3ciaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 PHE A 270
ALA A 318
LEU A 264
PHE A 262
 None
 1.09A 4uymA-3da1A:
undetectable		 4uymA-3da1A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 TYR A 149
ALA A  13
ILE A 336
LEU A  26
 None
 1.05A 4uymA-3fefA:
undetectable		 4uymA-3fefA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 TYR A 348
SER A 332
LEU A 432
PHE A 355
 None
 1.03A 4uymA-3gdnA:
undetectable		 4uymA-3gdnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00694
(Aconitase_C) 		4 PHE A 153
ALA A 137
LEU A 163
PHE A   4
 None
None
EDO  A1301 (-4.4A)
None
 0.90A 4uymA-3h5jA:
undetectable		 4uymA-3h5jA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iic CHEC DOMAIN PROTEIN

(Shewanella
loihica) 		PF13690
(CheX) 		4 PHE A 111
ALA A 100
SER A  12
ILE A 148
 None
 0.93A 4uymA-3iicA:
undetectable		 4uymA-3iicA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7y ASPARTATE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00155
(Aminotran_1_2) 		4 TYR A 348
PHE A 328
ALA A 395
LEU A 361
 None
 1.03A 4uymA-3k7yA:
undetectable		 4uymA-3k7yA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mgl SULFATE PERMEASE
FAMILY PROTEIN

(Vibrio cholerae) 		PF01740
(STAS) 		4 SER A 497
ILE A 495
LEU A 473
PHE A 498
 None
 0.90A 4uymA-3mglA:
undetectable		 4uymA-3mglA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0u NUCLEAR RECEPTOR
SUBFAMILY 2 GROUP C
MEMBER 2

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 ALA A 425
ILE A 533
LEU A 519
PHE A 520
 None
 1.08A 4uymA-3p0uA:
undetectable		 4uymA-3p0uA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmc UNCHARACTERIZED
PROTEIN
PXO2-61/BXB0075/GBAA
_PXO2_0075

(Bacillus
anthracis) 		PF09385
(HisK_N) 		4 PHE A 120
ALA A  91
LEU A  12
PHE A  19
 None
 1.02A 4uymA-3pmcA:
undetectable		 4uymA-3pmcA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0o CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		4 ALA A  71
SER A  68
ILE A  26
LEU A 121
 None
 0.79A 4uymA-3r0oA:
undetectable		 4uymA-3r0oA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rhg PUTATIVE
PHOPHOTRIESTERASE

(Proteus
mirabilis) 		PF02126
(PTE) 		4 TYR A 239
ALA A 276
LEU A 250
PHE A 252
 None
 0.90A 4uymA-3rhgA:
undetectable		 4uymA-3rhgA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shq UBLCP1

(Drosophila
melanogaster) 		PF00240
(ubiquitin)
PF03031
(NIF) 		4 ALA A 297
ILE A 251
LEU A 306
PHE A 303
 None
 1.03A 4uymA-3shqA:
undetectable		 4uymA-3shqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ALA A 812
SER A 808
ILE A 806
LEU A 872
 None
 0.97A 4uymA-3szeA:
undetectable		 4uymA-3szeA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uel POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Rattus
norvegicus) 		PF05028
(PARG_cat) 		4 PHE A 676
ILE A 553
LEU A 569
PHE A 661
 None
 0.69A 4uymA-3uelA:
undetectable		 4uymA-3uelA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aay AROB

(Rhizobium sp.
NT-26) 		PF00355
(Rieske) 		4 ALA B 141
SER B 126
LEU B 145
PHE B 128
 None
FES  B2006 (-2.9A)
None
None
 1.07A 4uymA-4aayB:
undetectable		 4uymA-4aayB:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 SER A 891
ILE A 889
LEU A 808
PHE A 892
 None
 1.05A 4uymA-4ay2A:
undetectable		 4uymA-4ay2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 PHE A 303
ILE A 291
LEU A 281
PHE A 282
 None
 0.95A 4uymA-4b8bA:
undetectable		 4uymA-4b8bA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans) 		PF10275
(Peptidase_C65) 		4 PHE B  65
ILE B 271
LEU B  72
PHE B  50
 None
 1.10A 4uymA-4dhiB:
1.4		 4uymA-4dhiB:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		4 ALA A 388
ILE A 291
LEU A 190
PHE A 118
 None
 1.06A 4uymA-4dziA:
undetectable		 4uymA-4dziA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 PHE A 508
ALA A 424
ILE A 389
LEU A 463
 None
 1.05A 4uymA-4h7uA:
undetectable		 4uymA-4h7uA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvo N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Schizosaccharomyces
pombe) 		PF12569
(NARP1) 		4 TYR A 546
PHE A 193
ALA A 153
LEU A 158
 None
 0.75A 4uymA-4kvoA:
0.1		 4uymA-4kvoA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8t UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF01843
(DIL) 		4 PHE A1443
SER A1733
ILE A1730
LEU A1378
 None
 0.60A 4uymA-4l8tA:
undetectable		 4uymA-4l8tA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ltu FERREDOXIN

(Rhodopseudomonas
palustris) 		PF00111
(Fer2) 		4 ALA A  26
ILE A  35
LEU A  99
PHE A   5
 None
 1.06A 4uymA-4ltuA:
undetectable		 4uymA-4ltuA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ALA A 759
SER A 755
ILE A 753
LEU A 816
 None
 0.98A 4uymA-4om9A:
undetectable		 4uymA-4om9A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 PHE A 294
ALA A 360
ILE A 319
LEU A 179
 None
 0.86A 4uymA-4pj6A:
undetectable		 4uymA-4pj6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 PHE H 467
SER H 336
ILE H 292
LEU H 500
 None
 0.71A 4uymA-4qfkH:
undetectable		 4uymA-4qfkH:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s38 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF04551
(GcpE) 		4 TYR A 397
PHE A 390
ALA A 339
LEU A 336
 None
 0.82A 4uymA-4s38A:
undetectable		 4uymA-4s38A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr6 DNA POLYMERASE III
SUBUNIT BETA

(Bacillus
subtilis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A   5
ILE A  87
LEU A  79
PHE A  84
 None
 0.81A 4uymA-4tr6A:
undetectable		 4uymA-4tr6A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx8 PROBABLE CHITINASE A

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18) 		4 ALA A 323
ILE A 301
LEU A 350
PHE A 368
 None
 1.07A 4uymA-4tx8A:
undetectable		 4uymA-4tx8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8d SORCIN

(Homo sapiens) 		PF13405
(EF-hand_6)
PF13833
(EF-hand_8) 		4 TYR A 159
PHE A  70
ALA A  64
ILE A 110
 None
 1.01A 4uymA-4u8dA:
1.1		 4uymA-4u8dA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		4 TYR A 131
PHE A 139
ALA A 311
ILE A 377
 VFV  A 580 (-4.1A)
VFV  A 580 (-4.2A)
HEM  A 540 ( 3.4A)
HEM  A 540 ( 3.9A)
 0.81A 4uymA-4uhiA:
47.7		 4uymA-4uhiA:
40.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi6 CYTOSOL
AMINOPEPTIDASE

(Helicobacter
pylori) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ALA A 160
ILE A   4
LEU A 112
PHE A 113
 None
 1.00A 4uymA-4zi6A:
0.3		 4uymA-4zi6A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3c SIR2 FAMILY PROTEIN

(Streptococcus
pyogenes) 		no annotation 4 PHE A 214
ALA A  27
ILE A  22
LEU A 107
 GLY  A1299 (-4.7A)
None
None
None
 1.07A 4uymA-5a3cA:
undetectable		 4uymA-5a3cA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE

(Drosophila
melanogaster) 		no annotation 4 PHE L 468
ALA L 360
LEU L 403
PHE L 399
 None
 1.05A 4uymA-5a7dL:
undetectable		 4uymA-5a7dL:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 TYR A 479
ALA A 720
SER A 723
LEU A 290
 None
 1.05A 4uymA-5ej1A:
2.3		 4uymA-5ej1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewq AMIDASE

(Bacillus
anthracis) 		PF01425
(Amidase) 		4 TYR A  94
ALA A 122
ILE A 140
PHE A 184
 None
 1.03A 4uymA-5ewqA:
undetectable		 4uymA-5ewqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fcl CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Pectobacterium
atrosepticum) 		PF01867
(Cas_Cas1) 		4 ALA A 202
ILE A 282
LEU A 154
PHE A 160
 None
 0.98A 4uymA-5fclA:
0.4		 4uymA-5fclA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhc ANTIBODY 100 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ALA A  95
SER A  35
ILE A  78
LEU A   4
 None
 1.06A 4uymA-5fhcA:
undetectable		 4uymA-5fhcA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PHE A  80
ALA A  69
ILE A  55
LEU A 145
 None
 0.95A 4uymA-5fokA:
undetectable		 4uymA-5fokA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 PHE A 103
ALA A 120
ILE A 193
LEU A 191
 None
 0.95A 4uymA-5h04A:
undetectable		 4uymA-5h04A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh9 PVDN

(Pseudomonas
aeruginosa) 		PF00266
(Aminotran_5) 		4 TYR A 235
ALA A 251
SER A 249
ILE A 213
 None
 1.03A 4uymA-5hh9A:
undetectable		 4uymA-5hh9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i08 SPIKE GLYCOPROTEIN,
ENVELOPE
GLYCOPROTEIN CHIMERA

(Human
coronavirus
HKU1;
Human
immunodeficiency
virus 1) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind)
PF16451
(Spike_NTD) 		4 TYR A 213
PHE A 202
SER A 122
LEU A 146
 None
 0.72A 4uymA-5i08A:
undetectable		 4uymA-5i08A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izd D-GLYCERALDEHYDE
DEHYDROGENASE
(NADP(+))

(Thermoplasma
acidophilum) 		PF00171
(Aldedh) 		4 ALA A 160
ILE A 184
LEU A 198
PHE A 188
 None
 1.09A 4uymA-5izdA:
undetectable		 4uymA-5izdA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jr4 TYPE 1 FIMBIRAL
ADHESIN FIMH

(Escherichia
coli) 		PF00419
(Fimbrial)
PF09160
(FimH_man-bind) 		4 ALA A 119
SER A  70
LEU A  34
PHE A  71
 None
 1.03A 4uymA-5jr4A:
undetectable		 4uymA-5jr4A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 PHE A 196
ALA A 149
SER A 181
LEU A 166
 None
 0.92A 4uymA-5kztA:
undetectable		 4uymA-5kztA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mx0 FIBROMODULIN

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 332
ILE A 330
LEU A 368
PHE A 333
 None
 1.03A 4uymA-5mx0A:
undetectable		 4uymA-5mx0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl0 HISTONE H1.0-B

(Xenopus laevis) 		PF00538
(Linker_histone) 		4 ALA Z  89
ILE Z  50
LEU Z  81
PHE Z  93
 None
 0.92A 4uymA-5nl0Z:
undetectable		 4uymA-5nl0Z:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 2
CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 4 PHE C 485
ALA A  54
ILE A 103
LEU A  61
 None
 1.04A 4uymA-5oqrC:
undetectable		 4uymA-5oqrC:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfq BETA-LACTAMASE

(Bacteroides
cellulosilyticus) 		PF13354
(Beta-lactamase2) 		4 PHE A  52
ALA A 174
LEU A  59
PHE A 180
 None
 0.89A 4uymA-5tfqA:
undetectable		 4uymA-5tfqA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 ALA F   8
ILE F 399
LEU F  31
PHE F  25
 None
 1.04A 4uymA-5u7xF:
undetectable		 4uymA-5u7xF:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w87 PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC6

(Homo sapiens) 		no annotation 4 PHE A 946
SER A 915
ILE A 928
PHE A 968
 None
 0.87A 4uymA-5w87A:
undetectable		 4uymA-5w87A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyh CBSA

(Xanthomonas
oryzae) 		no annotation 4 TYR A 351
SER A 299
LEU A 277
PHE A 301
 None
 1.03A 4uymA-5xyhA:
undetectable		 4uymA-5xyhA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2p -

(-) 		no annotation 4 TYR A  87
ALA A  18
ILE A  92
LEU A  23
 None
 0.86A 4uymA-5y2pA:
undetectable		 4uymA-5y2pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S25E

(Leishmania
donovani) 		no annotation 4 PHE a  42
ALA a  76
ILE a  60
LEU a  83
 None
 0.71A 4uymA-6az1a:
undetectable		 4uymA-6az1a:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b6l GLYCOSYL HYDROLASE
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 PHE A 469
ALA A 457
SER A 422
LEU A 442
 None
 0.95A 4uymA-6b6lA:
undetectable		 4uymA-6b6lA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2h CYSTATHIONINE
BETA-SYNTHASE

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 274
PHE A 317
ILE A  35
LEU A  29
 None
 0.87A 4uymA-6c2hA:
undetectable		 4uymA-6c2hA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esb CAPSID PROTEIN VP1

(Human
polyomavirus 1) 		no annotation 4 ALA 1 130
SER 1 132
ILE 1 144
PHE 1 270
 None
 1.01A 4uymA-6esb1:
undetectable		 4uymA-6esb1:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f91 PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		no annotation 4 ALA A 597
ILE A 583
LEU A 564
PHE A 565
 None
 0.87A 4uymA-6f91A:
undetectable		 4uymA-6f91A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9c GLYCOPROTEIN

(Rift Valley
fever
phlebovirus) 		no annotation 4 ALA A 257
SER A 296
ILE A 169
LEU A 212
 None
 1.07A 4uymA-6f9cA:
undetectable		 4uymA-6f9cA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy8 -

(-) 		no annotation 4 ALA A  98
ILE A  51
LEU A 202
PHE A 198
 None
 1.00A 4uymA-6gy8A:
undetectable		 4uymA-6gy8A:
undetectable