SIMILAR PATTERNS OF AMINO ACIDS FOR 4UY8_7_TRP71002_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f6d UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Escherichia
coli) 		PF02350
(Epimerase_2) 		4 ILE A 239
ASN A 264
ILE A 266
VAL A 242
 None
 1.27A 4uy87-1f6dA:
undetectable		 4uy87-1f6dA:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyn FRUCTOSE-BISPHOSPHAT
E ALDOLASE II

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		4 ILE A 287
ASN A 286
ILE A  57
VAL A  56
 None
 1.30A 4uy87-1gynA:
undetectable		 4uy87-1gynA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hna GLUTATHIONE
S-TRANSFERASE

(Homo sapiens) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 ILE A  98
ASN A 101
ILE A 158
VAL A 155
 None
 1.13A 4uy87-1hnaA:
undetectable		 4uy87-1hnaA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ILE A 343
ASN A 341
ILE A 377
VAL A 365
 None
 1.18A 4uy87-1iyxA:
undetectable		 4uy87-1iyxA:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 ILE A 792
ASN A 793
ILE A 848
VAL A 921
 None
 1.31A 4uy87-1jx2A:
undetectable		 4uy87-1jx2A:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8f ADENYLYL
CYCLASE-ASSOCIATED
PROTEIN

(Homo sapiens) 		PF08603
(CAP_C) 		4 ILE A 367
ASN A 368
ILE A 388
VAL A 389
 None
 1.29A 4uy87-1k8fA:
undetectable		 4uy87-1k8fA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 107
ASN A 142
ILE A 121
VAL A  63
 None
 1.29A 4uy87-1kfiA:
undetectable		 4uy87-1kfiA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A 120
ASN A 118
ILE A  74
VAL A   3
 None
 1.31A 4uy87-1lrkA:
undetectable		 4uy87-1lrkA:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mo0 TRIOSEPHOSPHATE
ISOMERASE

(Caenorhabditis
elegans) 		PF00121
(TIM) 		4 ILE A 159
ASN A 158
ILE A 120
VAL A  90
 None
 1.17A 4uy87-1mo0A:
undetectable		 4uy87-1mo0A:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8b PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG

(Aquifex
aeolicus) 		PF01895
(PhoU) 		4 ILE A 104
ASN A 103
ILE A  50
VAL A  49
 None
 1.07A 4uy87-1t8bA:
undetectable		 4uy87-1t8bA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 ILE A 257
ASN A 260
ILE A 349
VAL A 345
 None
 1.27A 4uy87-1tj7A:
undetectable		 4uy87-1tj7A:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwm PHOSPHATE UPTAKE
REGULATOR

(Geobacillus
stearothermophilus) 		PF01895
(PhoU) 		4 ILE A 100
ASN A  99
ILE A  46
VAL A  45
 None
 1.18A 4uy87-1xwmA:
undetectable		 4uy87-1xwmA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 ILE A 287
ASN A  34
ILE A 326
VAL A 331
 None
 1.14A 4uy87-2b9bA:
undetectable		 4uy87-2b9bA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE A 217
ASN A 215
ILE A 436
VAL A 233
 None
 1.18A 4uy87-2cgjA:
undetectable		 4uy87-2cgjA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqb PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  64
ASN A  68
ILE A  77
VAL A  10
 None
 0.98A 4uy87-2cqbA:
undetectable		 4uy87-2cqbA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d42 NON-TOXIC CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 ILE A 100
ASN A  99
ILE A   3
VAL A  94
 None
 1.17A 4uy87-2d42A:
undetectable		 4uy87-2d42A:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc5 GLUTATHIONE
S-TRANSFERASE, MU 7

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A 106
ASN A 109
ILE A 166
VAL A 163
 None
 0.98A 4uy87-2dc5A:
undetectable		 4uy87-2dc5A:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dnp RNA-BINDING PROTEIN
14

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A 129
ASN A 133
ILE A 142
VAL A  83
 None
 1.12A 4uy87-2dnpA:
undetectable		 4uy87-2dnpA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		4 ILE A 266
ASN A 267
ILE A  38
VAL A  35
 None
 1.22A 4uy87-2dr1A:
undetectable		 4uy87-2dr1A:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euc HYPOTHETICAL PROTEIN
YFMB

(Bacillus
subtilis) 		PF11486
(DUF3212) 		4 ILE A  14
ASN A  11
ILE A  54
VAL A  51
 None
 1.31A 4uy87-2eucA:
undetectable		 4uy87-2eucA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuv PHOSPHOGLUCOMUTASE

(Salmonella
enterica) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ILE A 127
ASN A 158
ILE A 141
VAL A  83
 None
 1.24A 4uy87-2fuvA:
undetectable		 4uy87-2fuvA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 ILE A 252
ASN A 248
ILE A 110
VAL A 109
 None
 1.20A 4uy87-2gb3A:
undetectable		 4uy87-2gb3A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 ILE A 401
ASN A 402
ILE A 292
VAL A 346
 None
 1.29A 4uy87-2gduA:
undetectable		 4uy87-2gduA:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh9 THIAMIN
PYROPHOSPHOKINASE

(Candida
albicans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 ILE A  34
ASN A 243
ILE A 318
VAL A 319
 None
 1.26A 4uy87-2hh9A:
undetectable		 4uy87-2hh9A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hig 6-PHOSPHO-1-FRUCTOKI
NASE

(Trypanosoma
brucei) 		PF00365
(PFK) 		4 ILE A 292
ASN A 291
ILE A 450
VAL A 447
 None
 1.30A 4uy87-2higA:
undetectable		 4uy87-2higA:
3.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3a N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 250
ASN A 320
ILE A 294
VAL A 293
 None
 1.29A 4uy87-2i3aA:
undetectable		 4uy87-2i3aA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3e T7I23.11 PROTEIN

(Arabidopsis
thaliana) 		PF04548
(AIG1) 		4 ILE A  89
ASN A  87
ILE A  57
VAL A  53
 None
 1.27A 4uy87-2j3eA:
undetectable		 4uy87-2j3eA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jah CLAVULANIC ACID
DEHYDROGENASE

(Streptomyces
clavuligerus) 		PF00106
(adh_short) 		4 ILE A  12
ASN A  91
ILE A 183
VAL A 224
 None
NDP  A1248 (-3.2A)
None
None
 1.04A 4uy87-2jahA:
undetectable		 4uy87-2jahA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kos ACYL CARRIER PROTEIN

(Streptomyces
coelicolor) 		PF00550
(PP-binding) 		4 ILE A  21
ASN A  16
ILE A  14
VAL A  46
 None
 1.10A 4uy87-2kosA:
undetectable		 4uy87-2kosA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A 577
ASN A 581
ILE A 552
VAL A 568
 None
None
None
CA  A1293 ( 4.9A)
 1.29A 4uy87-2np0A:
undetectable		 4uy87-2np0A:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		4 ILE A 183
ASN A 184
ILE A 195
VAL A 378
 None
 1.09A 4uy87-2pefA:
undetectable		 4uy87-2pefA:
4.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qby CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG 1

(Sulfolobus
solfataricus) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		4 ILE A 178
ASN A  58
ILE A 175
VAL A 141
 None
 1.18A 4uy87-2qbyA:
undetectable		 4uy87-2qbyA:
4.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		4 ILE A 375
ASN A 384
ILE A 274
VAL A 399
 None
CTS  A1544 (-3.9A)
None
None
 1.11A 4uy87-2vl8A:
undetectable		 4uy87-2vl8A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		4 ILE A 110
ASN A  57
ILE A 175
VAL A 172
 None
GOL  A1343 ( 4.5A)
None
None
 1.24A 4uy87-2wymA:
undetectable		 4uy87-2wymA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xci 3-DEOXY-D-MANNO-2-OC
TULOSONIC ACID
TRANSFERASE

(Aquifex
aeolicus) 		PF04413
(Glycos_transf_N) 		4 ILE A 219
ASN A 216
ILE A 183
VAL A 188
 None
GOL  A1357 (-3.1A)
None
None
 1.13A 4uy87-2xciA:
undetectable		 4uy87-2xciA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ILE A 464
ASN A 466
ILE A 506
VAL A 499
 None
 1.20A 4uy87-2xvgA:
undetectable		 4uy87-2xvgA:
1.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywk PUTATIVE RNA-BINDING
PROTEIN 11

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  67
ASN A  71
ILE A  80
VAL A  14
 None
 1.13A 4uy87-2ywkA:
undetectable		 4uy87-2ywkA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 ILE A 139
ASN A 140
ILE A 166
VAL A 190
 None
 1.31A 4uy87-2za1A:
undetectable		 4uy87-2za1A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsu SPERMIDINE SYNTHASE

(Pyrococcus
horikoshii) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ILE A 149
ASN A 152
ILE A 141
VAL A 106
 None
 1.21A 4uy87-2zsuA:
undetectable		 4uy87-2zsuA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		4 ILE A 479
ASN A 481
ILE A 487
VAL A 528
 None
 1.26A 4uy87-3b8kA:
undetectable		 4uy87-3b8kA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1t TYPE I SITE-SPECIFIC
RESTRICTION-MODIFICA
TION SYSTEM, R
(RESTRICTION)
SUBUNIT

(Vibrio
vulnificus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF13588
(HSDR_N_2) 		4 ILE A 185
ASN A 188
ILE A 218
VAL A 214
 None
 1.05A 4uy87-3h1tA:
undetectable		 4uy87-3h1tA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis) 		PF00923
(TAL_FSA) 		4 ILE A 311
ASN A 315
ILE A 317
VAL A  73
 None
 1.30A 4uy87-3igxA:
undetectable		 4uy87-3igxA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxz ALKYLPURINE DNA
GLYCOSYLASE ALKD

(Bacillus cereus) 		PF08713
(DNA_alkylation) 		4 ILE A 144
ASN A 143
ILE A 103
VAL A 112
 None
 1.01A 4uy87-3jxzA:
undetectable		 4uy87-3jxzA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 ILE A 217
ASN A 243
ILE A 255
VAL A 235
 None
 1.23A 4uy87-3l0gA:
undetectable		 4uy87-3l0gA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8a PUTATIVE
AMINOTRANSFERASE,
PROBABLE
BETA-CYSTATHIONASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		4 ILE A  50
ASN A  51
ILE A 275
VAL A 272
 None
 1.22A 4uy87-3l8aA:
undetectable		 4uy87-3l8aA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpy PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  64
ASN A  68
ILE A  77
VAL A  10
 None
 1.00A 4uy87-3lpyA:
undetectable		 4uy87-3lpyA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p19 PUTATIVE BLUE
FLUORESCENT PROTEIN

(Vibrio
vulnificus) 		PF00106
(adh_short) 		4 ILE A   7
ASN A  80
ILE A 173
VAL A 215
 None
NDP  A2001 ( 3.3A)
None
None
 1.03A 4uy87-3p19A:
undetectable		 4uy87-3p19A:
4.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm3 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Campylobacter
jejuni) 		PF01116
(F_bP_aldolase) 		4 ILE A 118
ASN A 121
ILE A  82
VAL A  78
 None
 1.03A 4uy87-3qm3A:
undetectable		 4uy87-3qm3A:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 ILE A  66
ASN A  63
ILE A  61
VAL A 295
 None
 1.26A 4uy87-3ruyA:
undetectable		 4uy87-3ruyA:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 ILE A 943
ASN A 917
ILE A 920
VAL A 921
 None
 1.16A 4uy87-3sfzA:
undetectable		 4uy87-3sfzA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8k UNCHARACTERIZED
PROTEIN

(Leptotrichia
buccalis) 		no annotation 4 ILE A 119
ASN A 118
ILE A 113
VAL A 114
 None
 1.25A 4uy87-3t8kA:
undetectable		 4uy87-3t8kA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u2p RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 ILE A 379
ASN A 378
ILE A 312
VAL A 323
 None
 0.98A 4uy87-3u2pA:
undetectable		 4uy87-3u2pA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4c BACILYSIN
BIOSYNTHESIS
OXIDOREDUCTASE YWFH

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		4 ILE A  90
ASN A  88
ILE A 118
VAL A 115
 NDP  A 262 (-4.9A)
None
None
None
 1.12A 4uy87-3u4cA:
undetectable		 4uy87-3u4cA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7u RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 ILE A 379
ASN A 378
ILE A 312
VAL A 323
 None
 0.90A 4uy87-3u7uA:
undetectable		 4uy87-3u7uA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ILE A 307
ASN A 303
ILE A 335
VAL A 552
 None
 1.27A 4uy87-3um6A:
undetectable		 4uy87-3um6A:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wst PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Caenorhabditis
elegans) 		PF13649
(Methyltransf_25) 		4 ILE A 637
ASN A 638
ILE A 528
VAL A 529
 None
 0.97A 4uy87-3wstA:
undetectable		 4uy87-3wstA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 ILE A 613
ASN A 617
ILE A 588
VAL A 604
 None
 1.30A 4uy87-3zuqA:
undetectable		 4uy87-3zuqA:
2.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 ILE A 528
ASN A 483
ILE A 485
VAL A 486
 None
 1.30A 4uy87-4a5wA:
undetectable		 4uy87-4a5wA:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aby DNA REPAIR PROTEIN
RECN

(Deinococcus
radiodurans) 		PF02463
(SMC_N) 		4 ILE A  87
ASN A  41
ILE A  39
VAL A  96
 None
 1.11A 4uy87-4abyA:
undetectable		 4uy87-4abyA:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		4 ILE A 170
ASN A 166
ILE A 111
VAL A 107
 None
 1.23A 4uy87-4bsnA:
undetectable		 4uy87-4bsnA:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ed5 ELAV-LIKE PROTEIN 1

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  78
ASN A  82
ILE A  91
VAL A  24
 EDO  A 208 (-4.0A)
M2M  A 206 (-2.9A)
None
None
 1.03A 4uy87-4ed5A:
undetectable		 4uy87-4ed5A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		4 ILE A 217
ASN A 219
ILE A 291
VAL A 315
 None
 1.29A 4uy87-4ehjA:
undetectable		 4uy87-4ehjA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emw COENZYME A DISULFIDE
REDUCTASE

(Staphylococcus
aureus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ILE A 272
ASN A 271
ILE A 309
VAL A 305
 None
 1.30A 4uy87-4emwA:
undetectable		 4uy87-4emwA:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gip FUSION GLYCOPROTEIN
F2
FUSION GLYCOPROTEIN
F1

(Mammalian
rubulavirus 5;
Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly)
PF00523
(Fusion_gly) 		4 ILE D 287
ASN A  34
ILE D 326
VAL D 331
 None
 1.12A 4uy87-4gipD:
undetectable		 4uy87-4gipD:
4.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A   6
ASN A   8
ILE A  25
VAL A  24
 None
 1.27A 4uy87-4gisA:
undetectable		 4uy87-4gisA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9j IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE
SUBUNIT HISF

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		4 ILE A  33
ASN A   7
ILE A   5
VAL A  30
 None
 1.29A 4uy87-4j9jA:
undetectable		 4uy87-4j9jA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		4 ILE A  49
ASN A  46
ILE A  11
VAL A 219
 None
 1.11A 4uy87-4kpoA:
undetectable		 4uy87-4kpoA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhw GLUTATHIONE
S-TRANSFERASE

(Sinorhizobium
meliloti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A  57
ASN A  58
ILE A  63
VAL A  31
 None
None
GSH  A 301 (-4.1A)
None
 1.20A 4uy87-4nhwA:
undetectable		 4uy87-4nhwA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcv BDCA (YJGI)

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 ILE A 105
ASN A 106
ILE A 129
VAL A  81
 None
 1.02A 4uy87-4pcvA:
undetectable		 4uy87-4pcvA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pz7 MRNA-CAPPING ENZYME
SUBUNIT ALPHA

(Schizosaccharomyces
pombe) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		4 ILE A 249
ASN A 335
ILE A 311
VAL A 312
 None
SO4  A 502 (-3.9A)
None
None
 1.28A 4uy87-4pz7A:
undetectable		 4uy87-4pz7A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rae HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		4 ILE A  96
ASN A  95
ILE A  89
VAL A 214
 None
 1.26A 4uy87-4raeA:
undetectable		 4uy87-4raeA:
3.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 ILE A2427
ASN A2461
ILE A1588
VAL A2437
 None
 1.21A 4uy87-4rlvA:
undetectable		 4uy87-4rlvA:
2.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy8 TRYPTOPHANASE

(Escherichia
coli) 		PF08053
(Tna_leader) 		4 ILE 7  15
ASN 7  17
ILE 7  19
VAL 7  20
 TRP  71002 (-3.3A)
TRP  71002 (-3.9A)
C  A2610 ( 3.9A)
TRP  71002 (-4.5A)
 0.00A 4uy87-4uy87:
undetectable		 4uy87-4uy87:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb1 319AA LONG
HYPOTHETICAL
HOMOSERINE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 ILE A  87
ASN A  86
ILE A  35
VAL A  34
 None
 1.07A 4uy87-4xb1A:
undetectable		 4uy87-4xb1A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		4 ILE A 709
ASN A 713
ILE A 715
VAL A 747
 None
 1.11A 4uy87-4zhjA:
undetectable		 4uy87-4zhjA:
1.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2d HN PROTEIN

(Mumps
rubulavirus) 		PF00423
(HN) 		4 ILE A 413
ASN A 145
ILE A 312
VAL A 410
 None
 1.18A 4uy87-5b2dA:
undetectable		 4uy87-5b2dA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv3 M7GPPPX
DIPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 ILE A 295
ASN A 234
ILE A 269
VAL A 258
 None
 1.17A 4uy87-5bv3A:
undetectable		 4uy87-5bv3A:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbk SHHTL5

(Striga
hermonthica) 		PF12697
(Abhydrolase_6) 		4 ILE A 261
ASN A 265
ILE A  90
VAL A  20
 None
 1.15A 4uy87-5cbkA:
undetectable		 4uy87-5cbkA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ILE D 205
ASN D 204
ILE D 169
VAL D 172
 None
 1.26A 4uy87-5fl7D:
undetectable		 4uy87-5fl7D:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		4 ILE E  15
ASN E  14
ILE E  98
VAL E  94
 None
 1.18A 4uy87-5ginE:
undetectable		 4uy87-5ginE:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		4 ILE A 140
ASN A 198
ILE A 200
VAL A 143
 None
 1.03A 4uy87-5j1dA:
undetectable		 4uy87-5j1dA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsy PERIPLASMIC [NIFESE]
HYDROGENASE, SMALL
SUBUNIT

(Desulfovibrio
vulgaris) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE A 156
ASN A 155
ILE A  76
VAL A  75
 None
 1.25A 4uy87-5jsyA:
undetectable		 4uy87-5jsyA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		4 ILE A 608
ASN A 607
ILE A 192
VAL A 189
 ZPE  A 703 ( 4.9A)
ZPE  A 703 ( 3.9A)
ZPE  A 703 ( 4.7A)
None
 1.18A 4uy87-5lc8A:
undetectable		 4uy87-5lc8A:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5llt NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Plasmodium
falciparum) 		PF01467
(CTP_transf_like) 		4 ILE A 166
ASN A 164
ILE A 134
VAL A  23
 None
None
DND  A 301 ( 4.5A)
None
 0.88A 4uy87-5lltA:
undetectable		 4uy87-5lltA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lph CENTROSOMAL PROTEIN
OF 104 KDA

(Homo sapiens) 		no annotation 4 ILE A 659
ASN A 658
ILE A 664
VAL A 630
 None
 1.22A 4uy87-5lphA:
undetectable		 4uy87-5lphA:
4.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0j SWI5-DEPENDENT HO
EXPRESSION PROTEIN
2,SWI5-DEPENDENT HO
EXPRESSION PROTEIN 3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE D 194
ASN D 193
ILE D 178
VAL D 174
 None
 1.24A 4uy87-5m0jD:
undetectable		 4uy87-5m0jD:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 ILE A1070
ASN A1069
ILE A 907
VAL A 906
 None
 0.84A 4uy87-5n0cA:
undetectable		 4uy87-5n0cA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncw SERPIN-TYPE
PROTEINASE
INHIBITOR, MIROPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		4 ILE A 129
ASN A 130
ILE A 141
VAL A 322
 None
CL  A 513 (-4.5A)
None
None
 1.05A 4uy87-5ncwA:
undetectable		 4uy87-5ncwA:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 4 ILE A4444
ASN A4445
ILE A4447
VAL A4448
 None
 1.10A 4uy87-5o6cA:
undetectable		 4uy87-5o6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 4 ILE A  22
ASN A  21
ILE A 257
VAL A 254
 None
 1.30A 4uy87-5oklA:
undetectable		 4uy87-5oklA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		4 ILE A 520
ASN A 519
ILE A 514
VAL A 513
 CLR  A 701 (-4.9A)
CLR  A 701 (-3.5A)
None
None
 1.30A 4uy87-5sy1A:
undetectable		 4uy87-5sy1A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 ILE A 383
ASN A 384
ILE A 378
VAL A 405
 None
 1.31A 4uy87-5u47A:
undetectable		 4uy87-5u47A:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 CAPSID VERTEX
PROTEIN GP24

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 ILE a 210
ASN a 211
ILE a  39
VAL a  40
 None
 1.00A 4uy87-5vf3a:
undetectable		 4uy87-5vf3a:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7p OXAC

(Penicillium
oxalicum) 		no annotation 4 ILE A 365
ASN A 180
ILE A 162
VAL A 159
 None
 1.25A 4uy87-5w7pA:
undetectable		 4uy87-5w7pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8r PROTEIN CS22

(Spinacia
oleracea) 		no annotation 4 ILE v  80
ASN v  84
ILE v  93
VAL v  26
 None
 0.93A 4uy87-5x8rv:
undetectable		 4uy87-5x8rv:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbl CRISPR-ASSOCIATED
ENDONUCLEASE
CAS9/CSN1

(Streptococcus
pyogenes) 		PF13395
(HNH_4)
PF16592
(Cas9_REC)
PF16593
(Cas9-BH)
PF16595
(Cas9_PI) 		4 ILE A 956
ASN A 758
ILE A  21
VAL A 992
 None
 1.31A 4uy87-5xblA:
undetectable		 4uy87-5xblA:
1.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjm TYPE-2 ANGIOTENSIN
II RECEPTOR,SOLUBLE
CYTOCHROME
B562,TYPE-2
ANGIOTENSIN II
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ILE A  63
ASN A  62
ILE A  57
VAL A  56
 None
 1.18A 4uy87-5xjmA:
undetectable		 4uy87-5xjmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b9h PROTEIN HOOK HOMOLOG
3

(Homo sapiens) 		no annotation 4 ILE A  79
ASN A  75
ILE A  73
VAL A 103
 None
 1.19A 4uy87-6b9hA:
undetectable		 4uy87-6b9hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey0 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM

(Porphyromonas
gingivalis) 		no annotation 4 ILE A 116
ASN A 114
ILE A 193
VAL A 190
 None
 1.30A 4uy87-6ey0A:
undetectable		 4uy87-6ey0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1k TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY C
MEMBER 4A

(Danio rerio) 		no annotation 4 ILE A 158
ASN A 154
ILE A 721
VAL A 717
 None
 1.25A 4uy87-6g1kA:
undetectable		 4uy87-6g1kA:
undetectable