SIMILAR PATTERNS OF AMINO ACIDS FOR 4UXQ_A_0LIA1752_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1blk P55 BLK PROTEIN
TYROSINE KINASE

(Mus musculus) 		PF00017
(SH2) 		4 VAL A  54
LYS A  65
ILE A  79
ILE A  83
 None
 0.84A 4uxqA-1blkA:
undetectable		 4uxqA-1blkA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  41
ILE A  87
ARG A 152
ILE A 169
 ANP  A 400 (-4.1A)
ANP  A 400 (-4.9A)
TPO  A 183 ( 2.8A)
None
 0.75A 4uxqA-1cm8A:
19.2		 4uxqA-1cm8A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxz GLYCININ G1

(Glycine max) 		PF00190
(Cupin_1) 		4 VAL A 392
ILE A 146
ALA A  46
ILE A 147
 None
 0.84A 4uxqA-1fxzA:
undetectable		 4uxqA-1fxzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 120
ALA A 112
ARG A 210
ILE A  47
 None
 0.83A 4uxqA-1orfA:
undetectable		 4uxqA-1orfA:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 352
LYS A 369
ALA A 417
ILE A 398
 STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
STU  A 100 (-3.7A)
None
 0.77A 4uxqA-1u59A:
30.7		 4uxqA-1u59A:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 352
LYS A 369
MET A 390
ALA A 417
ILE A 477
 STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
STU  A 100 (-3.7A)
None
 0.83A 4uxqA-1u59A:
30.7		 4uxqA-1u59A:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybm UNKNOWN PROTEIN
AT5G02240

(Arabidopsis
thaliana) 		PF13460
(NAD_binding_10) 		4 VAL A  20
ILE A 172
ALA A 215
ILE A 171
 None
 0.52A 4uxqA-1ybmA:
undetectable		 4uxqA-1ybmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		4 VAL A 412
ILE A 402
ALA A 443
ILE A 401
 None
 0.76A 4uxqA-1yp4A:
undetectable		 4uxqA-1yp4A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkd DUF185

(Rhodopseudomonas
palustris) 		PF02636
(Methyltransf_28) 		4 VAL A 231
ILE A 240
ARG A 306
ILE A 241
 None
 0.76A 4uxqA-1zkdA:
undetectable		 4uxqA-1zkdA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmf RNA HELICASE

(Dengue virus) 		PF07652
(Flavi_DEAD) 		4 VAL A 275
ILE A 281
ALA A 296
ILE A 282
 None
 0.77A 4uxqA-2bmfA:
undetectable		 4uxqA-2bmfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gh8 CAPSID PROTEIN

(Vesicular
exanthema of
swine virus) 		PF00915
(Calici_coat) 		4 MET A 279
ILE A 218
ALA A 699
ILE A 320
 None
 0.74A 4uxqA-2gh8A:
undetectable		 4uxqA-2gh8A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 VAL A 356
LYS A 371
ARG A 465
ILE A 482
 PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
TPO  A 500 ( 2.9A)
None
 0.88A 4uxqA-2i0eA:
14.5		 4uxqA-2i0eA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inv INSULIN
FRUCTOTRANSFERASE

(Bacillus sp.
snu-7) 		no annotation 4 VAL A 113
ILE A 102
ALA A  70
ILE A 101
 None
 0.77A 4uxqA-2invA:
undetectable		 4uxqA-2invA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jqa HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF04314
(PCuAC) 		4 VAL A 124
ALA A  69
ARG A 149
ILE A  42
 None
 0.86A 4uxqA-2jqaA:
undetectable		 4uxqA-2jqaA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 855
ILE A 886
ALA A 905
ILE A 980
 MR9  A 301 ( 4.6A)
MR9  A 301 (-4.0A)
MR9  A 301 (-3.6A)
MR9  A 301 (-4.6A)
 0.69A 4uxqA-2p4iA:
26.8		 4uxqA-2p4iA:
44.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 495
MET A 538
ILE A 548
ALA A 567
ARG A 625
ILE A 642
 None
None
None
None
SO4  A 303 ( 2.9A)
None
 1.07A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0l THIOREDOXIN
REDUCTASE

(Helicobacter
pylori) 		PF07992
(Pyr_redox_2) 		4 VAL A  25
ILE A   6
ALA A 300
ILE A   7
 None
 0.80A 4uxqA-2q0lA:
undetectable		 4uxqA-2q0lA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2re1 ASPARTOKINASE, ALPHA
AND BETA SUBUNITS

(Neisseria
meningitidis) 		PF01842
(ACT)
PF13840
(ACT_7) 		4 VAL A 285
ILE A 295
ALA A 278
ILE A 296
 None
 0.83A 4uxqA-2re1A:
undetectable		 4uxqA-2re1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL C  63
LYS C  78
ILE C 111
ILE C 192
 ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
 0.65A 4uxqA-2wtkC:
22.4		 4uxqA-2wtkC:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 234
LYS A 249
ILE A 286
ILE A 366
 XK9  A1511 (-4.8A)
XK9  A1511 (-4.2A)
None
None
 0.82A 4uxqA-2xk9A:
19.7		 4uxqA-2xk9A:
25.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 VAL A 635
LYS A 653
MET A 674
ILE A 683
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.9A)
 0.68A 4uxqA-2xyuA:
28.8		 4uxqA-2xyuA:
34.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 495
ILE A 548
ALA A 567
ARG A 625
ILE A 642
 M33  A1996 ( 4.7A)
None
M33  A1996 (-3.8A)
None
None
 1.11A 4uxqA-3b2tA:
28.4		 4uxqA-3b2tA:
73.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 495
MET A 538
ILE A 548
ALA A 567
ARG A 625
 M33  A1996 ( 4.7A)
None
None
M33  A1996 (-3.8A)
None
 1.30A 4uxqA-3b2tA:
28.4		 4uxqA-3b2tA:
73.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
LYS A 514
ILE A 545
ALA A 564
ARG A 622
ILE A 639
 None
None
C4F  A   1 ( 4.0A)
C4F  A   1 (-3.5A)
None
None
 0.74A 4uxqA-3c4fA:
38.3		 4uxqA-3c4fA:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
MET A 535
ILE A 545
ALA A 564
ARG A 622
ILE A 639
 None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
C4F  A   1 (-3.5A)
None
None
 0.77A 4uxqA-3c4fA:
38.3		 4uxqA-3c4fA:
73.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 VAL C 151
ILE C  10
ALA C 119
ILE C   9
 None
 0.73A 4uxqA-3degC:
undetectable		 4uxqA-3degC:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dho STREPTOGRAMIN A
ACETYLTRANSFERASE

(Enterococcus
faecium) 		PF00132
(Hexapep) 		4 VAL A 126
ILE A 116
ALA A 138
ILE A 115
 None
 0.78A 4uxqA-3dhoA:
undetectable		 4uxqA-3dhoA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 158
ILE A 204
ALA A 223
ARG A 267
ILE A 292
 VIN  A6331 (-4.7A)
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.8A)
None
None
 0.77A 4uxqA-3dtcA:
26.4		 4uxqA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 158
LYS A 171
ALA A 223
ILE A 203
 VIN  A6331 (-4.7A)
None
VIN  A6331 (-3.8A)
None
 0.82A 4uxqA-3dtcA:
26.4		 4uxqA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 158
LYS A 171
ILE A 204
ALA A 223
ILE A 292
 VIN  A6331 (-4.7A)
None
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.8A)
None
 0.83A 4uxqA-3dtcA:
26.4		 4uxqA-3dtcA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A  23
LYS A  38
MET A  54
ILE A  63
 None
None
None
DRK  A 384 ( 4.5A)
 0.73A 4uxqA-3eb0A:
21.0		 4uxqA-3eb0A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh7 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 VAL A 370
ILE A 314
ALA A 361
ILE A 327
 None
 0.72A 4uxqA-3eh7A:
undetectable		 4uxqA-3eh7A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		4 VAL A  55
ILE A  36
ALA A  80
ILE A  34
 None
 0.84A 4uxqA-3f8tA:
undetectable		 4uxqA-3f8tA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		4 VAL A  29
ALA A  94
ARG A 135
ILE A 157
 None
 0.86A 4uxqA-3gbzA:
18.4		 4uxqA-3gbzA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  38
LYS A  53
ILE A  84
ILE A 166
 NIL  A   1 ( 4.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 ( 4.9A)
 0.33A 4uxqA-3gp0A:
22.9		 4uxqA-3gp0A:
29.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		4 VAL A1316
ILE A1403
ALA A1390
ARG A1523
 None
 0.85A 4uxqA-3hmjA:
undetectable		 4uxqA-3hmjA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128

(Homo sapiens) 		PF02225
(PA) 		4 VAL A  49
ILE A 171
ALA A  45
ILE A 145
 None
 0.86A 4uxqA-3icuA:
undetectable		 4uxqA-3icuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 LYS A  82
MET A 104
ALA A 132
ARG A 174
ILE A 191
 None
 0.80A 4uxqA-3iecA:
22.3		 4uxqA-3iecA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		5 VAL A  67
LYS A  82
MET A 104
ALA A 132
ILE A 191
 None
 0.83A 4uxqA-3iecA:
22.3		 4uxqA-3iecA:
29.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 VAL A  91
ILE A 131
ALA A 141
ILE A 130
 None
 0.87A 4uxqA-3ifeA:
undetectable		 4uxqA-3ifeA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 VAL A 509
ILE A 516
ALA A 501
ILE A 517
 None
 0.74A 4uxqA-3k13A:
undetectable		 4uxqA-3k13A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0z PUTATIVE
NICOTINATE-NUCLEOTID
E-DIMETHYLBENZIMIDAZ
OLE
PHOSPHORIBOSYLTRANSF
ERASE

(Methanocaldococcus
jannaschii) 		PF02277
(DBI_PRT) 		4 VAL A 148
ILE A 249
ALA A 228
ILE A 252
 None
 0.81A 4uxqA-3l0zA:
undetectable		 4uxqA-3l0zA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		4 VAL A 689
ILE A 729
ARG A 796
ILE A 826
 ADP  A2101 (-4.5A)
None
TPO  A 844 ( 3.0A)
None
 0.88A 4uxqA-3lj0A:
21.7		 4uxqA-3lj0A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  47
LYS A  62
ILE A  94
ALA A 113
ILE A 177
 QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-3.9A)
None
 0.59A 4uxqA-3lm5A:
23.8		 4uxqA-3lm5A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		4 VAL A  44
ILE A  90
ALA A 114
ILE A 172
 ANP  A 430 (-4.2A)
ANP  A 430 ( 4.5A)
ANP  A 430 (-3.9A)
None
 0.60A 4uxqA-3nieA:
20.6		 4uxqA-3nieA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  96
MET A 134
ALA A 162
ARG A 204
ILE A 221
 JOZ  A 361 ( 4.7A)
None
JOZ  A 361 (-3.8A)
SEP  A 241 ( 3.4A)
None
 1.03A 4uxqA-3nuuA:
23.8		 4uxqA-3nuuA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		4 VAL A  39
LYS A  54
ILE A  85
ILE A 167
 1N1  A1000 (-4.6A)
1N1  A1000 (-4.5A)
1N1  A1000 ( 4.1A)
None
 0.66A 4uxqA-3ohtA:
17.2		 4uxqA-3ohtA:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 VAL A  71
ILE A 128
ARG A 189
ILE A 209
 ANP  A1634 (-4.1A)
None
None
None
 0.64A 4uxqA-3q5iA:
20.0		 4uxqA-3q5iA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qy7 TYROSINE-PROTEIN
PHOSPHATASE YWQE

(Bacillus
subtilis) 		no annotation 4 VAL A 133
ILE A  38
ALA A 228
ILE A  37
 None
 0.85A 4uxqA-3qy7A:
undetectable		 4uxqA-3qy7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 VAL A 334
ILE A 425
ARG A 318
ILE A 383
 None
 0.77A 4uxqA-3s51A:
undetectable		 4uxqA-3s51A:
14.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 492
LYS A 514
ILE A 545
ALA A 564
ILE A 544
 07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
 1.38A 4uxqA-3tt0A:
38.7		 4uxqA-3tt0A:
69.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
LYS A 514
MET A 535
ILE A 545
ALA A 564
ILE A 639
 07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
 0.69A 4uxqA-3tt0A:
38.7		 4uxqA-3tt0A:
69.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 848
LYS A 868
ARG A1027
ILE A1044
 4TT  A2001 ( 4.5A)
None
None
None
 0.56A 4uxqA-3vidA:
29.4		 4uxqA-3vidA:
48.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnv GLYOXYLATE REDUCTASE

(Paecilomyces
sp.
'thermophila') 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 VAL A 262
ILE A 248
ALA A 252
ILE A 224
 None
 0.74A 4uxqA-3wnvA:
undetectable		 4uxqA-3wnvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		4 VAL A  45
ILE A 219
ARG A 380
ILE A 220
 9VU  A1539 (-3.9A)
None
None
None
 0.66A 4uxqA-4bqhA:
undetectable		 4uxqA-4bqhA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		4 ILE A 302
ALA A 321
ARG A 363
ILE A 380
 None
 0.81A 4uxqA-4c0tA:
22.8		 4uxqA-4c0tA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		4 VAL A 254
ILE A 302
ALA A 321
ILE A 380
 None
 0.35A 4uxqA-4c0tA:
22.8		 4uxqA-4c0tA:
14.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 624
LYS A 655
ILE A 685
ILE A 782
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.5A)
 0.83A 4uxqA-4ckrA:
31.1		 4uxqA-4ckrA:
37.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 VAL A 671
ALA A 740
ARG A 781
ILE A 798
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.9A)
TPO  A 816 ( 3.0A)
None
 0.49A 4uxqA-4crsA:
16.0		 4uxqA-4crsA:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 VAL A 385
ALA A 451
ARG A 493
ILE A 510
 ANP  A 701 (-4.1A)
ANP  A 701 (-4.1A)
None
None
 0.75A 4uxqA-4fl3A:
29.3		 4uxqA-4fl3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  37
LYS A  52
ARG A 145
ILE A 162
 STU  A 401 ( 4.9A)
None
None
None
 0.73A 4uxqA-4fr4A:
20.7		 4uxqA-4fr4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhj MIF4G
DOMAIN-CONTAINING
PROTEIN B

(Danio rerio) 		PF02854
(MIF4G) 		4 MET A 122
ILE A 111
ALA A  55
ILE A 108
 None
 0.66A 4uxqA-4jhjA:
undetectable		 4uxqA-4jhjA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 486
LYS A 508
MET A 529
ILE A 539
 ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
None
 0.54A 4uxqA-4k33A:
30.1		 4uxqA-4k33A:
74.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
MET A 529
ILE A 539
ALA A 558
ARG A 616
ILE A 633
 ACP  A 801 (-4.2A)
None
None
ACP  A 801 (-3.7A)
None
None
 1.16A 4uxqA-4k33A:
30.1		 4uxqA-4k33A:
74.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A  50
LYS A  63
ALA A 107
ILE A 173
 1UL  A 501 ( 4.9A)
None
1UL  A 501 (-3.6A)
None
 0.64A 4uxqA-4l52A:
19.8		 4uxqA-4l52A:
29.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
vulgatus) 		PF13204
(DUF4038)
PF16586
(DUF5060) 		4 VAL A 115
ILE A 351
ARG A 347
ILE A 385
 None
 0.86A 4uxqA-4n0rA:
undetectable		 4uxqA-4n0rA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 911
LYS A 930
ILE A 960
ILE A1039
 2TT  A1202 (-4.5A)
None
None
None
 0.59A 4uxqA-4oliA:
28.0		 4uxqA-4oliA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 VAL A 607
ALA A 487
ARG A 583
ILE A 529
 None
 0.66A 4uxqA-4pf1A:
undetectable		 4uxqA-4pf1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qre METHIONYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 VAL A  28
ILE A 323
ALA A 330
ILE A 321
 None
 0.86A 4uxqA-4qreA:
undetectable		 4uxqA-4qreA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		4 VAL B  38
LYS B  53
ILE B  84
ILE B 166
 None
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
None
 0.79A 4uxqA-4tyhB:
21.3		 4uxqA-4tyhB:
27.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 204
ALA A 223
ARG A 267
ILE A 292
 None
 0.68A 4uxqA-4uy9A:
26.6		 4uxqA-4uy9A:
31.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 158
ILE A 204
ALA A 223
ILE A 292
 None
 0.49A 4uxqA-4uy9A:
26.6		 4uxqA-4uy9A:
31.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uya MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLK4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 138
ILE A 184
ALA A 203
ARG A 262
ILE A 287
 AGS  A1438 (-4.4A)
AGS  A1438 (-4.2A)
AGS  A1438 (-3.7A)
None
None
 0.78A 4uxqA-4uyaA:
25.4		 4uxqA-4uyaA:
32.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 481
LYS A 503
MET A 524
ILE A 534
ALA A 553
ILE A 628
 40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
 0.81A 4uxqA-4xcuA:
38.5		 4uxqA-4xcuA:
94.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 VAL A 206
ILE A 224
ARG A 350
ILE A 368
 None
 0.88A 4uxqA-4yzoA:
undetectable		 4uxqA-4yzoA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL31

(Human
alphaherpesvirus
1) 		PF02718
(Herpes_UL31) 		4 VAL B 256
ILE B 191
ALA B 237
ARG B 155
 None
 0.75A 4uxqA-4zxsB:
undetectable		 4uxqA-4zxsB:
22.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
MET A 535
ILE A 545
ALA A 564
ARG A 622
ILE A 639
 38O  A1769 (-4.5A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-3.9A)
None
None
 0.70A 4uxqA-5a46A:
38.5		 4uxqA-5a46A:
64.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT

(Streptomyces) 		PF04820
(Trp_halogenase) 		4 VAL A 168
ILE A  12
ALA A 137
ILE A  11
 None
FAD  A 501 (-4.9A)
None
None
 0.66A 4uxqA-5bulA:
undetectable		 4uxqA-5bulA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 738
ILE A 788
ALA A 807
ARG A 873
ILE A 890
 PP1  A2012 (-4.4A)
None
PP1  A2012 ( 3.5A)
SEP  A 909 ( 3.0A)
None
 1.24A 4uxqA-5fm2A:
34.8		 4uxqA-5fm2A:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A  30
ALA A  85
ARG A 132
ILE A 149
 032  A 401 (-4.4A)
032  A 401 (-3.6A)
None
None
 0.69A 4uxqA-5hesA:
25.6		 4uxqA-5hesA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A  30
ILE A  66
ALA A  85
ILE A 149
 032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-3.6A)
None
 0.70A 4uxqA-5hesA:
25.6		 4uxqA-5hesA:
30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A  30
LYS A  45
ILE A  66
ALA A  85
ILE A  65
 032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-3.6A)
None
 1.22A 4uxqA-5hesA:
25.6		 4uxqA-5hesA:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A  35
ILE A  79
ALA A 100
ARG A 150
ILE A 171
 6A7  A 401 ( 4.5A)
6A7  A 401 (-4.2A)
6A7  A 401 (-3.7A)
None
None
 0.55A 4uxqA-5idnA:
15.3		 4uxqA-5idnA:
24.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LYS A 665
MET A 686
ILE A 695
ARG A 757
 None
6P6  A1001 ( 4.2A)
None
None
 0.87A 4uxqA-5l6oA:
32.2		 4uxqA-5l6oA:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 VAL A 506
ILE A 668
ALA A 531
ILE A 633
 None
 0.87A 4uxqA-5m5pA:
undetectable		 4uxqA-5m5pA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol0 PUTATIVE SILENT
INFORMATION
REGULATOR 2,PUTATIVE
SILENT INFORMATION
REGULATOR 2

(Leishmania
infantum) 		no annotation 4 VAL A 231
MET A 219
ARG A 332
ILE A 215
 None
 0.73A 4uxqA-5ol0A:
undetectable		 4uxqA-5ol0A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 577
ILE A 513
ALA A 427
ILE A 512
 None
 0.75A 4uxqA-5tf0A:
undetectable		 4uxqA-5tf0A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 VAL A 182
MET A  75
ARG A  11
ILE A  30
 None
 0.78A 4uxqA-5tv2A:
undetectable		 4uxqA-5tv2A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9c DTDP-4-DEHYDRORHAMNO
SE REDUCTASE

(Yersinia
enterocolitica) 		PF04321
(RmlD_sub_bind) 		4 VAL A  18
ILE A 149
ALA A 203
ILE A 148
 None
 0.66A 4uxqA-5u9cA:
undetectable		 4uxqA-5u9cA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj5 ADRENODOXIN

(Encephalitozoon
cuniculi) 		PF00111
(Fer2) 		4 VAL A  42
ILE A  18
ALA A 111
ARG A  13
 None
 0.79A 4uxqA-5uj5A:
undetectable		 4uxqA-5uj5A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5un0 PROTEASOME ASSEMBLY
CHAPERONE 2 (PAC2)
HOMOLOGUE RV2125

(Mycobacterium
tuberculosis) 		PF09754
(PAC2) 		4 VAL 1 123
ILE 1  83
ALA 1  20
ILE 1  51
 None
 0.82A 4uxqA-5un01:
undetectable		 4uxqA-5un01:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
REGULATORY SUBUNIT
6B

(Homo sapiens) 		no annotation 4 VAL D 177
ILE D 261
ALA D 220
ILE D 262
 None
 0.78A 4uxqA-5vfrD:
undetectable		 4uxqA-5vfrD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xaq PROBABLE
D-TYROSYL-TRNA(TYR)
DEACYLASE 2

(Mus musculus) 		no annotation 4 VAL A 130
ILE A  89
ARG A  21
ILE A  90
 None
 0.85A 4uxqA-5xaqA:
undetectable		 4uxqA-5xaqA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zal ENDORIBONUCLEASE
DICER

(Homo sapiens) 		no annotation 4 VAL A 312
ILE A 446
ALA A 454
ILE A 445
 None
 0.75A 4uxqA-5zalA:
undetectable		 4uxqA-5zalA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8d ELONGATION FACTOR G

(Haemophilus
influenzae) 		no annotation 4 VAL A 182
MET A  75
ARG A  11
ILE A  30
 None
 0.85A 4uxqA-6b8dA:
undetectable		 4uxqA-6b8dA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 4 VAL A  74
LYS A  89
MET A 111
ALA A 139
 None
 0.78A 4uxqA-6c9dA:
21.6		 4uxqA-6c9dA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 5 VAL A  74
MET A 111
ALA A 139
ARG A 181
ILE A 198
 None
 0.92A 4uxqA-6c9dA:
21.6		 4uxqA-6c9dA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 4 VAL A 200
LYS A 213
ARG A 310
ILE A 327
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.0A)
TPO  A 345 ( 4.9A)
None
 0.87A 4uxqA-6f3dA:
24.0		 4uxqA-6f3dA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 4 VAL A 738
ILE A 788
ALA A 807
ILE A 890
 ADN  A1104 (-4.4A)
ADN  A1104 ( 4.7A)
ADN  A1104 (-3.6A)
None
 0.41A 4uxqA-6fekA:
34.1		 4uxqA-6fekA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 VAL P  34
ILE P 166
ALA P 217
ILE P 165
 None
 0.57A 4uxqA-6g2jP:
undetectable		 4uxqA-6g2jP:
16.22