SIMILAR PATTERNS OF AMINO ACIDS FOR 4UXQ_A_0LIA1752_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
LEU A 715
HIS A 722
LEU A 731
ALA A 741
 None
 0.53A 4uxqA-1lufA:
34.8		 4uxqA-1lufA:
41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 288
GLU A 305
ILE A 312
LEU A 373
HIS A 380
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
None
None
P16  A   2 (-4.4A)
 0.85A 4uxqA-1opkA:
30.4		 4uxqA-1opkA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
ALA A 288
GLU A 305
LEU A 373
HIS A 380
LEU A 389
ALA A 399
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.66A 4uxqA-1opkA:
30.4		 4uxqA-1opkA:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 230
LEU A 316
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
None
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.38A 4uxqA-1py5A:
26.2		 4uxqA-1py5A:
27.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 164
ALA A 185
HIS A 292
LEU A 301
ALA A 549
 ADP  A 810 ( 4.3A)
ADP  A 810 (-3.3A)
None
ADP  A 810 (-4.7A)
None
 0.54A 4uxqA-1q8yA:
21.0		 4uxqA-1q8yA:
23.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
GLU A 661
LEU A 802
HIS A 809
LEU A 818
 None
 0.62A 4uxqA-1rjbA:
34.2		 4uxqA-1rjbA:
43.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
ALA A 621
GLU A 640
CYH A 788
LEU A 799
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-2.8A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.73A 4uxqA-1t46A:
29.7		 4uxqA-1t46A:
49.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
ALA A 621
LEU A 783
CYH A 788
HIS A 790
LEU A 799
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
None
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.52A 4uxqA-1t46A:
29.7		 4uxqA-1t46A:
49.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
ALA A 367
GLU A 386
LEU A 452
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
STU  A 100 (-4.5A)
 0.59A 4uxqA-1u59A:
30.7		 4uxqA-1u59A:
35.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  15
ALA A  36
LEU A 121
HIS A 128
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
None
None
HYM  A 400 (-4.5A)
 0.59A 4uxqA-1zltA:
21.4		 4uxqA-1zltA:
28.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
ALA X  37
GLU X  54
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.58A 4uxqA-2dq7X:
31.8		 4uxqA-2dq7X:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU X  17
ALA X  37
HIS X 128
LEU X 137
ALA X 147
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.48A 4uxqA-2dq7X:
31.8		 4uxqA-2dq7X:
35.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 162
ALA A 184
GLU A 201
ILE A 208
ALA A 319
 None
 0.52A 4uxqA-2eu9A:
21.7		 4uxqA-2eu9A:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
ALA A 293
HIS A 384
LEU A 393
ALA A 403
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.58A 4uxqA-2h8hA:
30.3		 4uxqA-2h8hA:
25.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
ALA A 293
HIS A 384
LEU A 393
ALA A 403
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.50A 4uxqA-2hckA:
29.7		 4uxqA-2hckA:
35.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
GLU A 286
ILE A 293
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.53A 4uxqA-2hz0A:
32.0		 4uxqA-2hz0A:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
ILE A 293
LEU A 354
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.5A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.92A 4uxqA-2hz0A:
32.0		 4uxqA-2hz0A:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ILE A 293
LEU A 354
HIS A 361
LEU A 370
ALA A 380
 GIN  A 600 ( 4.6A)
GIN  A 600 (-4.5A)
GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.90A 4uxqA-2hz0A:
32.0		 4uxqA-2hz0A:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 354
HIS A 361
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 ( 4.6A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.62A 4uxqA-2hz0A:
32.0		 4uxqA-2hz0A:
40.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
GLU A 288
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.66A 4uxqA-2og8A:
31.9		 4uxqA-2og8A:
40.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
ALA A 271
GLU A 288
HIS A 362
ALA A 381
ASP A 382
PHE A 383
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.73A 4uxqA-2og8A:
31.9		 4uxqA-2og8A:
40.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
ALA A 614
GLU A 633
LEU A 769
CYH A 774
HIS A 776
LEU A 785
 None
 0.59A 4uxqA-2ogvA:
33.5		 4uxqA-2ogvA:
45.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LEU A 955
HIS A 962
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-4.4A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.49A 4uxqA-2p4iA:
26.8		 4uxqA-2p4iA:
44.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU X  34
ALA X  53
ILE X  95
HIS X 170
LEU X 179
 HMD  X 400 ( 4.3A)
HMD  X 400 (-3.5A)
None
None
HMD  X 400 (-4.7A)
 0.53A 4uxqA-2pmoX:
21.4		 4uxqA-2pmoX:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
ILE A 541
LEU A 617
CYH A 622
LEU A 633
ALA A 643
 None
 0.79A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
ILE A 541
LEU A 617
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 None
 0.71A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
ALA A 515
GLU A 534
LEU A 617
CYH A 622
LEU A 633
ALA A 643
 None
 0.64A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
ALA A 515
VAL A 564
LEU A 617
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 None
 0.60A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 724
ALA A 749
LEU A 834
HIS A 841
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
None
None
GW7  A   1 (-4.2A)
 0.61A 4uxqA-2r4bA:
29.4		 4uxqA-2r4bA:
35.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  47
LEU A 131
HIS A 138
LEU A 147
ALA A 157
 J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.56A 4uxqA-2xikA:
19.0		 4uxqA-2xikA:
26.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
ALA A 515
VAL A 564
LEU A 617
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
None
None
None
None
M33  A1996 (-4.5A)
None
 0.45A 4uxqA-3b2tA:
28.4		 4uxqA-3b2tA:
73.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A1108
LEU A1195
HIS A1202
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-4.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.53A 4uxqA-3c1xA:
25.6		 4uxqA-3c1xA:
30.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 484
ALA A 512
GLU A 531
VAL A 561
LEU A 614
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 ( 3.9A)
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 4.8A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.58A 4uxqA-3c4fA:
38.3		 4uxqA-3c4fA:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
GLU A 531
LEU A 614
CYH A 619
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 ( 3.9A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.90A 4uxqA-3c4fA:
38.3		 4uxqA-3c4fA:
73.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 663
GLU A 682
LEU A 749
HIS A 756
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.68A 4uxqA-3dkoA:
32.6		 4uxqA-3dkoA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 663
LEU A 749
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
None
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.50A 4uxqA-3dkoA:
32.6		 4uxqA-3dkoA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 833
ALA A 859
GLU A 878
VAL A 909
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
None
None
 0.82A 4uxqA-3hngA:
34.8		 4uxqA-3hngA:
46.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
ALA A 859
ILE A 885
VAL A 909
LEU A1013
CYH A1018
HIS A1020
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
 0.85A 4uxqA-3hngA:
34.8		 4uxqA-3hngA:
46.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 833
ALA A 859
VAL A 909
LEU A1013
CYH A1018
HIS A1020
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.1A)
8ST  A2001 (-4.6A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
None
 0.68A 4uxqA-3hngA:
34.8		 4uxqA-3hngA:
46.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		5 LEU A 680
ALA A 700
LEU A 788
HIS A 795
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.5A)
None
None
ADP  A2101 (-4.4A)
 0.61A 4uxqA-3lj0A:
21.7		 4uxqA-3lj0A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 ALA A 229
LEU A 315
HIS A 330
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.55A 4uxqA-3mdyA:
25.8		 4uxqA-3mdyA:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 227
LEU A 313
HIS A 328
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
None
None
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.55A 4uxqA-3my0A:
25.3		 4uxqA-3my0A:
29.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 726
ALA A 751
LEU A 836
HIS A 843
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
None
None
03Q  A   1 (-4.4A)
 0.52A 4uxqA-3pp0A:
26.4		 4uxqA-3pp0A:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 345
LEU A 451
HIS A 458
LEU A 467
ALA A 477
 STU  A   1 (-3.8A)
None
None
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.26A 4uxqA-3s95A:
25.9		 4uxqA-3s95A:
30.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
GLU A 531
VAL A 561
LEU A 614
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
None
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.66A 4uxqA-3tt0A:
38.7		 4uxqA-3tt0A:
69.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
VAL A 561
LEU A 614
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 ( 4.3A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
None
None
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.61A 4uxqA-3tt0A:
38.7		 4uxqA-3tt0A:
69.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 570
LEU A 670
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-4.8A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.44A 4uxqA-3v5qA:
27.6		 4uxqA-3v5qA:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.81A 4uxqA-3vidA:
29.4		 4uxqA-3vidA:
48.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 ( 4.0A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.66A 4uxqA-3vidA:
29.4		 4uxqA-3vidA:
48.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 840
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
HIS A1026
LEU A1035
 LEV  A1201 ( 3.8A)
LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.6A)
None
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
 0.49A 4uxqA-3wzdA:
29.3		 4uxqA-3wzdA:
52.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
CYH A1024
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
None
 1.08A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
ILE A 892
VAL A 916
LEU A1019
HIS A1026
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
None
 0.98A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
GLU A 885
HIS A1026
LEU A1035
PHE A1047
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
B49  A2000 (-4.0A)
 0.93A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
ALA A 866
GLU A 885
VAL A 916
LEU A1019
CYH A1024
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
B49  A2000 (-4.5A)
 0.89A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
ALA A 866
GLU A 885
VAL A 916
LEU A1019
HIS A1026
LEU A1035
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.8A)
None
None
B49  A2000 (-4.5A)
 0.74A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 1.00A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
ALA A 866
LEU A1019
HIS A1026
LEU A1035
ASP A1046
 B49  A2000 (-3.7A)
B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
None
 0.69A 4uxqA-4agdA:
35.5		 4uxqA-4agdA:
48.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 233
LEU A 319
HIS A 334
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
None
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.33A 4uxqA-4c02A:
25.5		 4uxqA-4c02A:
28.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 653
GLU A 672
HIS A 764
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.73A 4uxqA-4ckrA:
31.1		 4uxqA-4ckrA:
37.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
LEU A 757
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.59A 4uxqA-4ckrA:
31.1		 4uxqA-4ckrA:
37.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 653
GLU A 672
HIS A 764
ALA A 783
ASP A 784
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.55A 4uxqA-4ckrA:
31.1		 4uxqA-4ckrA:
37.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 653
LEU A 757
HIS A 764
ALA A 783
ASP A 784
PHE A 785
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-4.4A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.84A 4uxqA-4ckrA:
31.1		 4uxqA-4ckrA:
37.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 ALA A 588
LEU A 674
CYH A 679
HIS A 681
LEU A 690
 GUI  A 901 (-3.4A)
None
None
None
GUI  A 901 (-4.3A)
 0.37A 4uxqA-4e93A:
32.6		 4uxqA-4e93A:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
ALA A 880
LEU A 967
HIS A 974
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
None
None
IZA  A2001 ( 4.7A)
 0.58A 4uxqA-4gl9A:
14.1		 4uxqA-4gl9A:
34.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
ALA A 853
GLU A 871
LEU A 940
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.63A 4uxqA-4hviA:
30.4		 4uxqA-4hviA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 828
ALA A 853
LEU A 940
CYH A 945
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.53A 4uxqA-4hviA:
30.4		 4uxqA-4hviA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 406
ALA A 427
LEU A 506
HIS A 513
LEU A 522
 T28  A 701 (-3.8A)
T28  A 701 (-3.0A)
None
None
T28  A 701 (-3.9A)
 0.62A 4uxqA-4idtA:
22.2		 4uxqA-4idtA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  18
ALA A  39
LEU A 127
LEU A 143
ALA A 153
 631  A 301 (-3.4A)
631  A 301 (-3.3A)
None
631  A 301 (-4.0A)
631  A 301 (-3.4A)
 0.49A 4uxqA-4jxfA:
19.0		 4uxqA-4jxfA:
26.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 273
ALA A 293
HIS A 384
LEU A 393
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.55A 4uxqA-4k11A:
29.8		 4uxqA-4k11A:
28.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
ALA A 506
GLU A 525
VAL A 555
LEU A 608
LEU A 624
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
None
ACP  A 801 (-4.4A)
None
 0.71A 4uxqA-4k33A:
30.1		 4uxqA-4k33A:
74.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
ALA A 506
VAL A 555
LEU A 608
HIS A 615
LEU A 624
ALA A 634
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 (-4.7A)
None
None
ACP  A 801 (-4.4A)
None
 0.61A 4uxqA-4k33A:
30.1		 4uxqA-4k33A:
74.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA B  51
LEU B 135
HIS B 142
LEU B 151
ALA B 161
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
 0.58A 4uxqA-4o27B:
20.0		 4uxqA-4o27B:
28.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
 0.71A 4uxqA-4rt7A:
29.5		 4uxqA-4rt7A:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ALA A 642
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.78A 4uxqA-4rt7A:
29.5		 4uxqA-4rt7A:
38.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 442
HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.7A)
35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.48A 4uxqA-4tptA:
21.7		 4uxqA-4tptA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 ALA A  35
LEU A 120
HIS A 127
LEU A 136
ALA A 146
 ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.8A)
None
 0.57A 4uxqA-4ueuA:
31.2		 4uxqA-4ueuA:
41.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  61
LEU A 146
HIS A 153
LEU A 162
ALA A 172
ASP A 173
 6UI  A 700 (-3.3A)
None
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
 0.93A 4uxqA-4usfA:
18.3		 4uxqA-4usfA:
27.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 473
ALA A 501
GLU A 520
VAL A 550
LEU A 603
CYH A 608
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
None
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.66A 4uxqA-4xcuA:
38.5		 4uxqA-4xcuA:
94.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
LEU A 802
HIS A 809
LEU A 818
ASP A 829
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
 0.61A 4uxqA-4xufA:
34.0		 4uxqA-4xufA:
47.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.86A 4uxqA-4xufA:
34.0		 4uxqA-4xufA:
47.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 LEU A 408
ALA A 428
LEU A 512
HIS A 519
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
None
746  A 702 (-4.4A)
 0.56A 4uxqA-4y93A:
31.0		 4uxqA-4y93A:
25.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
ALA A 512
GLU A 531
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.54A 4uxqA-5a46A:
38.5		 4uxqA-5a46A:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 484
ALA A 512
VAL A 561
LEU A 614
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.2A)
38O  A1769 (-3.6A)
38O  A1769 (-4.3A)
None
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.55A 4uxqA-5a46A:
38.5		 4uxqA-5a46A:
64.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 756
VAL A 804
LEU A 865
HIS A 872
LEU A 881
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
None
None
PP1  A2012 (-4.6A)
 0.46A 4uxqA-5fm2A:
34.8		 4uxqA-5fm2A:
48.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
ALA A 625
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.78A 4uxqA-5grnA:
27.2		 4uxqA-5grnA:
44.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
ALA A 625
LEU A 809
CYH A 814
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 ( 4.6A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.33A 4uxqA-5grnA:
27.2		 4uxqA-5grnA:
44.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 LEU A  20
ALA A  41
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.60A 4uxqA-5hu3A:
23.2		 4uxqA-5hu3A:
24.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 129
HIS A 136
LEU A 145
ALA A 155
ASP A 156
 65U  A 301 ( 4.6A)
65U  A 301 (-3.3A)
None
65U  A 301 ( 3.9A)
65U  A 301 (-4.7A)
 0.54A 4uxqA-5hx6A:
25.7		 4uxqA-5hx6A:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  50
LEU A 142
HIS A 149
LEU A 158
ALA A 172
 6A7  A 401 (-3.3A)
None
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.41A 4uxqA-5idnA:
15.3		 4uxqA-5idnA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  43
LEU A 127
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.60A 4uxqA-5j5tA:
21.7		 4uxqA-5j5tA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 663
LEU A 749
HIS A 756
LEU A 765
ASP A 776
 6P6  A1001 (-3.3A)
None
DIO  A1002 (-4.1A)
6P6  A1001 (-4.5A)
None
 0.30A 4uxqA-5l6oA:
32.2		 4uxqA-5l6oA:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 116
ALA A 137
GLU A 157
LEU A 224
HIS A 231
 H8H  A 401 (-3.7A)
H8H  A 401 (-3.3A)
None
None
None
 0.59A 4uxqA-5vcxA:
22.9		 4uxqA-5vcxA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 5 LEU A  24
ALA A  45
LEU A 135
LEU A 153
ALA A 163
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.44A 4uxqA-5w5jA:
12.5		 4uxqA-5w5jA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 LEU A  33
ALA A  54
LEU A 137
HIS A 144
LEU A 153
ALA A 163
 ANP  A 501 ( 3.8A)
ANP  A 501 ( 3.7A)
None
None
ANP  A 501 (-4.6A)
None
 0.59A 4uxqA-6ao5A:
22.1		 4uxqA-6ao5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
LEU A 303
HIS A 310
LEU A 319
ALA A 329
 BI9  A 501 (-3.3A)
None
None
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
 0.39A 4uxqA-6bqlA:
22.0		 4uxqA-6bqlA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 5 ALA A 155
LEU A 266
HIS A 273
LEU A 282
ALA A 292
 H1N  A 501 (-3.4A)
None
None
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
 0.37A 4uxqA-6ccfA:
22.1		 4uxqA-6ccfA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 5 ALA A 192
LEU A 303
HIS A 310
LEU A 319
ALA A 329
 F6J  A 501 (-3.4A)
None
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.53A 4uxqA-6cmjA:
22.3		 4uxqA-6cmjA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 6 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.62A 4uxqA-6cnhA:
22.0		 4uxqA-6cnhA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 6 GLU A 732
LEU A 806
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.7A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.72A 4uxqA-6cnhA:
22.0		 4uxqA-6cnhA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 LEU A 730
ALA A 756
VAL A 804
LEU A 865
HIS A 872
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
None
None
ADN  A1104 (-4.3A)
 0.55A 4uxqA-6fekA:
34.1		 4uxqA-6fekA:
26.55