SIMILAR PATTERNS OF AMINO ACIDS FOR 4UUU_B_SAMB1548_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dbv GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Geobacillus
stearothermophilus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER O 148
LEU O 154
PRO O 156
VAL O 129
THR O 127
SO4  O 339 (-2.9A)
None
None
None
None
1.14A 4uuuB-1dbvO:
undetectable
4uuuB-1dbvO:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN


(Propionibacterium
freudenreichii)
PF01642
(MM_CoA_mutase)
PF02310
(B12-binding)
5 SER A 656
ALA A 373
VAL A 687
THR A 706
ILE A 704
None
B12  A 800 (-4.5A)
B12  A 800 (-4.6A)
None
None
1.26A 4uuuB-1e1cA:
0.0
4uuuB-1e1cA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE


(Drosophila
melanogaster)
PF00274
(Glycolytic)
5 LEU A 356
GLN A 306
ALA A 307
ILE A  77
ASP A  33
None
1.23A 4uuuB-1fbaA:
0.0
4uuuB-1fbaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyq PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)


(Leishmania
mexicana)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 165
LEU A 171
PRO A 173
VAL A 145
THR A 143
None
1.22A 4uuuB-1gyqA:
undetectable
4uuuB-1gyqA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwp EBULIN

(Sambucus ebulus)
PF00652
(Ricin_B_lectin)
5 SER B  73
LEU B 118
GLN B 129
ALA B 109
PRO B 110
None
1.05A 4uuuB-1hwpB:
undetectable
4uuuB-1hwpB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
5 LEU A1373
ALA A1246
PRO A1247
VAL A1287
THR A1280
None
1.33A 4uuuB-1ihmA:
0.0
4uuuB-1ihmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE


(Azotobacter
vinelandii)
PF03971
(IDH)
5 SER A  87
ALA A 586
PRO A 587
THR A  11
ILE A  42
NAP  A1000 (-4.1A)
NAP  A1000 (-3.8A)
NAP  A1000 (-4.6A)
None
None
1.26A 4uuuB-1j1wA:
undetectable
4uuuB-1j1wA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A


(Spinacia
oleracea)
no annotation 5 SER O 148
LEU O 154
PRO O 156
VAL O 129
THR O 127
SO4  O6337 (-3.5A)
None
None
None
None
1.19A 4uuuB-1jn0O:
undetectable
4uuuB-1jn0O:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
5 SER A 103
LEU A  97
ALA A  95
VAL A  92
ILE A 121
None
1.17A 4uuuB-1kfiA:
0.0
4uuuB-1kfiA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT


(Homo sapiens)
PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8)
5 LEU L 166
ASP L 104
GLN L  99
ALA L 101
ILE L 111
None
1.28A 4uuuB-1kfuL:
undetectable
4uuuB-1kfuL:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kri VP4

(Rotavirus A)
PF00426
(VP4_haemagglut)
5 LEU A 164
ALA A  85
PRO A  86
THR A 105
ASP A 142
None
1.17A 4uuuB-1kriA:
undetectable
4uuuB-1kriA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum)
PF01975
(SurE)
5 ALA A 122
PRO A 121
VAL A 156
THR A 152
ILE A 262
None
1.13A 4uuuB-1l5xA:
undetectable
4uuuB-1l5xA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN


(Zea mays)
PF00069
(Pkinase)
5 SER A 294
LEU A 301
PHE A 222
ALA A 223
ASP A 130
None
1.29A 4uuuB-1m2pA:
undetectable
4uuuB-1m2pA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E


(Klebsiella
pneumoniae)
PF01636
(APH)
5 LEU A 241
ASP A 227
ALA A 237
VAL A 113
ILE A 196
None
KAN  A1300 (-3.8A)
None
None
None
1.23A 4uuuB-1nd4A:
undetectable
4uuuB-1nd4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT


(Halothiobacillus
neapolitanus)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 LEU A 383
GLN A 394
ALA A 371
VAL A 392
ASP A 191
None
1.28A 4uuuB-1svdA:
undetectable
4uuuB-1svdA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE


(Arthrobacter
sp. KM)
PF00480
(ROK)
5 LEU A 163
ASP A 123
VAL A 146
THR A 148
ILE A 153
None
BGC  A 290 (-2.9A)
None
None
None
1.33A 4uuuB-1woqA:
undetectable
4uuuB-1woqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqw PROLINE
IMINOPEPTIDASE


(Thermoplasma
acidophilum)
PF00561
(Abhydrolase_1)
5 LEU A 110
ALA A 109
VAL A 127
THR A 236
ILE A 234
None
1.25A 4uuuB-1xqwA:
undetectable
4uuuB-1xqwA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 LEU A 117
PHE A  94
ASP A  72
ALA A  74
THR A 113
None
None
None
None
CL  A 818 (-3.2A)
1.26A 4uuuB-1yb5A:
undetectable
4uuuB-1yb5A:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3i SIMILAR TO
RAD54-LIKE


(Danio rerio)
PF00176
(SNF2_N)
PF00271
(Helicase_C)
5 SER X 446
LEU X 417
PHE X 468
ASP X 469
GLN X 424
None
1.25A 4uuuB-1z3iX:
undetectable
4uuuB-1z3iX:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayi AMINOPEPTIDASE T

(Thermus
thermophilus)
PF02073
(Peptidase_M29)
5 PHE A  39
ALA A  36
PRO A  33
VAL A 101
ILE A  16
None
1.27A 4uuuB-2ayiA:
undetectable
4uuuB-2ayiA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Synechococcus
sp.)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 154
LEU A 160
PRO A 162
VAL A 134
THR A 132
SO4  A1339 (-2.9A)
None
None
None
None
1.17A 4uuuB-2d2iA:
undetectable
4uuuB-2d2iA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1t ACYL TRANSFERASE

(Chrysanthemum x
morifolium)
PF02458
(Transferase)
5 LEU A 345
GLN A 296
ALA A 328
THR A 382
ILE A 416
None
1.17A 4uuuB-2e1tA:
undetectable
4uuuB-2e1tA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep7 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Aquifex
aeolicus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 151
LEU A 157
PRO A 159
VAL A 131
THR A 129
None
1.19A 4uuuB-2ep7A:
undetectable
4uuuB-2ep7A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2


(Archaeoglobus
fulgidus)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 SER A 754
LEU A 364
ASP A 360
VAL A 369
ILE A 389
None
1.30A 4uuuB-2f3oA:
undetectable
4uuuB-2f3oA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis)
PF01979
(Amidohydro_1)
5 LEU A 200
PHE A 231
ASP A 230
GLN A 234
ALA A 235
None
1.28A 4uuuB-2icsA:
undetectable
4uuuB-2icsA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 ASP A 284
GLN A 915
VAL A 300
ILE A 281
ASP A 303
MGD  A1986 (-3.0A)
None
MGD  A1986 ( 4.0A)
MGD  A1986 (-4.1A)
MGD  A1986 (-2.9A)
1.28A 4uuuB-2ivfA:
undetectable
4uuuB-2ivfA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT


(Aromatoleum
aromaticum)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
5 SER A 451
ASP A 284
GLN A 915
VAL A 300
ASP A 303
MGD  A1986 (-4.5A)
MGD  A1986 (-3.0A)
None
MGD  A1986 ( 4.0A)
MGD  A1986 (-2.9A)
1.25A 4uuuB-2ivfA:
undetectable
4uuuB-2ivfA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n8a POLY [ADP-RIBOSE]
POLYMERASE 1


(Homo sapiens)
PF00645
(zf-PARP)
5 SER A 177
LEU A 195
PHE A 184
ALA A 115
THR A 109
None
1.03A 4uuuB-2n8aA:
undetectable
4uuuB-2n8aA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nad NAD-DEPENDENT
FORMATE
DEHYDROGENASE


(Pseudomonas sp.
101)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 373
ASP A 125
VAL A 139
THR A 119
ILE A 122
None
None
None
None
NAD  A 394 ( 3.5A)
1.32A 4uuuB-2nadA:
undetectable
4uuuB-2nadA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis)
PF02275
(CBAH)
5 LEU A   4
ALA A  16
THR A 276
ILE A 261
ASP A  20
None
1.26A 4uuuB-2oqcA:
undetectable
4uuuB-2oqcA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B


(Spinacia
oleracea)
PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C)
5 SER O 148
LEU O 154
PRO O 156
VAL O 129
THR O 127
None
1.20A 4uuuB-2pkqO:
undetectable
4uuuB-2pkqO:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A  67
ALA A 433
THR A  25
ILE A  23
ASP A  24
None
1.20A 4uuuB-2q27A:
undetectable
4uuuB-2q27A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5o PHENYLPYRUVATE
DECARBOXYLASE


(Azospirillum
brasilense)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A   3
ALA A 141
PRO A 142
VAL A 175
ASP A  13
None
1.30A 4uuuB-2q5oA:
undetectable
4uuuB-2q5oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quy PENICILLIN ACYLASE

(Lysinibacillus
sphaericus)
PF02275
(CBAH)
5 LEU A   4
ALA A  16
THR A 276
ILE A 261
ASP A  20
None
1.20A 4uuuB-2quyA:
undetectable
4uuuB-2quyA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens)
PF03372
(Exo_endo_phos)
5 LEU A 112
ASP A 145
GLN A  42
THR A  12
ILE A 231
None
GOL  A1240 (-2.7A)
None
None
None
1.21A 4uuuB-2v0sA:
undetectable
4uuuB-2v0sA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE


(Methanocaldococcus
jannaschii)
PF00814
(Peptidase_M22)
PF01163
(RIO1)
5 LEU A 126
GLN A 134
VAL A 145
THR A 316
ILE A 108
None
1.21A 4uuuB-2vwbA:
undetectable
4uuuB-2vwbA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL


(Trypanosoma
brucei)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 164
LEU A 170
PRO A 172
VAL A 144
THR A 142
SO4  A 360 (-2.6A)
None
None
None
None
1.26A 4uuuB-2x0nA:
undetectable
4uuuB-2x0nA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xw7 DIHYDROFOLATE
REDUCTASE


(Mycolicibacterium
smegmatis)
PF01872
(RibD_C)
5 ALA A 102
VAL A   1
THR A   3
ILE A 127
ASP A 128
None
1.15A 4uuuB-2xw7A:
undetectable
4uuuB-2xw7A:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus)
PF02224
(Cytidylate_kin)
5 LEU A  43
PHE A  42
ALA A  39
VAL A  93
THR A  90
None
1.25A 4uuuB-3akcA:
undetectable
4uuuB-3akcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b20 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE
(NADP+)


(Synechococcus
elongatus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 154
LEU A 160
PRO A 162
VAL A 134
THR A 132
SO4  A1339 (-2.7A)
None
None
None
None
1.20A 4uuuB-3b20A:
undetectable
4uuuB-3b20A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9p UNCHARACTERIZED
PROTEIN SP1917


(Streptococcus
pneumoniae)
PF09966
(DUF2200)
5 PHE A  59
ASP A  58
GLN A  62
ALA A  63
PRO A  64
None
1.18A 4uuuB-3c9pA:
undetectable
4uuuB-3c9pA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae)
PF00923
(TAL_FSA)
5 LEU A 164
ALA A 198
THR A  41
ILE A  46
ASP A  17
None
None
None
None
EDO  A 354 (-2.8A)
1.24A 4uuuB-3clmA:
undetectable
4uuuB-3clmA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbo UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN


(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis)
PF02604
(PhdYeFM_antitox)
PF01850
(PIN)
5 SER B  80
LEU B  75
ASP A  71
GLN B  73
ALA B  72
None
1.29A 4uuuB-3dboB:
undetectable
4uuuB-3dboB:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE


(Legionella
pneumophila)
PF03309
(Pan_kinase)
5 ASP A 108
ALA A 113
VAL A 127
THR A 135
ILE A 150
None
1.27A 4uuuB-3djcA:
undetectable
4uuuB-3djcA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezx MONOMETHYLAMINE
CORRINOID PROTEIN 1


(Methanosarcina
barkeri)
PF02310
(B12-binding)
PF02607
(B12-binding_2)
5 LEU A 213
PHE A 122
ALA A 209
THR A  98
ILE A  97
None
1.25A 4uuuB-3ezxA:
undetectable
4uuuB-3ezxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fby CARTILAGE OLIGOMERIC
MATRIX PROTEIN


(Homo sapiens)
PF02412
(TSP_3)
PF05735
(TSP_C)
5 ASP A 595
GLN A 729
ALA A 597
VAL A 588
ASP A 678
CA  A 829 ( 2.4A)
None
None
None
CA  A 828 (-2.6A)
1.25A 4uuuB-3fbyA:
undetectable
4uuuB-3fbyA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III


(Xanthomonas
oryzae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ASP A 149
ALA A  69
VAL A 104
THR A 100
ASP A  94
None
1.13A 4uuuB-3fk5A:
undetectable
4uuuB-3fk5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmx TARTRATE
DEHYDROGENASE/DECARB
OXYLASE


(Pseudomonas
putida)
PF00180
(Iso_dh)
5 SER X 189
PHE X 176
ASP X 177
VAL X 240
ILE X 171
None
0.96A 4uuuB-3fmxX:
undetectable
4uuuB-3fmxX:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE


(Shewanella
denitrificans)
PF01380
(SIS)
5 ASP A 104
GLN A 108
ALA A 109
VAL A  47
ASP A  53
None
1.11A 4uuuB-3hbaA:
undetectable
4uuuB-3hbaA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Borreliella
burgdorferi)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 152
LEU A 158
PRO A 160
VAL A 133
THR A 131
SO4  A 336 (-3.2A)
None
None
None
None
1.15A 4uuuB-3hjaA:
undetectable
4uuuB-3hjaA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE


(Mycobacterium
tuberculosis)
PF01048
(PNP_UDP_1)
5 LEU A 142
ASP A 138
ALA A 181
VAL A 210
THR A 213
None
1.16A 4uuuB-3iomA:
undetectable
4uuuB-3iomA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP0

(Parechovirus B)
PF00073
(Rhv)
5 PHE B 115
ALA B 123
PRO B 122
VAL B  89
ILE B 235
None
1.26A 4uuuB-3jb4B:
undetectable
4uuuB-3jb4B:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 148
LEU A 154
PRO A 156
VAL A 129
THR A 127
SO4  A 337 (-3.1A)
None
None
None
None
1.25A 4uuuB-3k2bA:
undetectable
4uuuB-3k2bA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Bartonella
henselae)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 152
LEU A 158
PRO A 160
VAL A 133
THR A 131
None
1.18A 4uuuB-3l0dA:
undetectable
4uuuB-3l0dA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE


(Corynebacterium
glutamicum)
PF13409
(GST_N_2)
PF13410
(GST_C_2)
5 LEU A  80
ALA A 170
PRO A 171
ILE A 345
ASP A 288
None
1.23A 4uuuB-3m1gA:
undetectable
4uuuB-3m1gA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mae 2-OXOISOVALERATE
DEHYDROGENASE E2
COMPONENT,
DIHYDROLIPOAMIDE
ACETYLTRANSFERASE


(Listeria
monocytogenes)
PF00198
(2-oxoacid_dh)
5 LEU A 262
PHE A 331
GLN A 352
ALA A 353
ILE A 294
None
1.28A 4uuuB-3maeA:
undetectable
4uuuB-3maeA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjf PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE


(Yersinia pestis)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 ALA A  50
PRO A  75
VAL A  70
THR A  68
ILE A   3
None
1.31A 4uuuB-3mjfA:
undetectable
4uuuB-3mjfA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA


(Escherichia
coli)
PF00873
(ACR_tran)
5 LEU A 357
ASP A 405
ALA A 366
VAL A 349
ILE A 992
None
1.19A 4uuuB-3ne5A:
undetectable
4uuuB-3ne5A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntd FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULPHID
E OXIDOREDUCTASE


(Shewanella
loihica)
PF00581
(Rhodanese)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 LEU A 399
ASP A 455
ALA A 461
VAL A 380
THR A 382
None
1.23A 4uuuB-3ntdA:
undetectable
4uuuB-3ntdA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE


(Aspergillus
fumigatus)
PF11991
(Trp_DMAT)
5 LEU A  68
ALA A  72
PRO A  71
THR A  40
ILE A  43
None
None
MES  A 475 ( 4.9A)
None
None
1.30A 4uuuB-3o2kA:
undetectable
4uuuB-3o2kA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p19 PUTATIVE BLUE
FLUORESCENT PROTEIN


(Vibrio
vulnificus)
PF00106
(adh_short)
5 SER A  11
LEU A  32
GLN A  51
ALA A  50
VAL A  36
NDP  A2001 ( 2.7A)
None
None
None
None
1.29A 4uuuB-3p19A:
undetectable
4uuuB-3p19A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster)
PF00291
(PALP)
PF00571
(CBS)
5 ASP A 412
GLN A 413
PRO A 415
THR A 496
ASP A 499
None
0.73A 4uuuB-3pc3A:
10.3
4uuuB-3pc3A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9s DNA-BINDING RESPONSE
REGULATOR


(Deinococcus
radiodurans)
PF00072
(Response_reg)
PF00486
(Trans_reg_C)
5 SER A 150
ASP A  99
GLN A 117
ILE A 177
ASP A 155
None
1.19A 4uuuB-3q9sA:
undetectable
4uuuB-3q9sA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxz POLYSACCHARIDE
DEACETYLASE


(Mycolicibacterium
smegmatis)
PF01522
(Polysacc_deac_1)
5 LEU A 167
PRO A 187
VAL A 188
THR A 237
ASP A 193
None
1.30A 4uuuB-3rxzA:
undetectable
4uuuB-3rxzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teb ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE


(Leptotrichia
buccalis)
PF03372
(Exo_endo_phos)
5 PHE A 174
ASP A 173
GLN A  38
THR A   5
ILE A 257
None
1.16A 4uuuB-3tebA:
undetectable
4uuuB-3tebA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdf GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Thermosynechococcus
elongatus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 153
LEU A 159
PRO A 161
VAL A 134
THR A 132
None
1.17A 4uuuB-3zdfA:
undetectable
4uuuB-3zdfA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arp PESTICIN

(Yersinia pestis)
PF16754
(Pesticin)
5 LEU A 346
ASP A 352
GLN A 348
ALA A 345
VAL A 326
None
1.24A 4uuuB-4arpA:
undetectable
4uuuB-4arpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c2k 3-KETOACYL-COA
THIOLASE,
MITOCHONDRIAL


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A  60
GLN A 124
ALA A 125
PRO A 126
ASP A  65
None
1.23A 4uuuB-4c2kA:
undetectable
4uuuB-4c2kA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE


(Bacillus
anthracis)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 150
LEU A 156
PRO A 158
VAL A 130
THR A 128
None
1.14A 4uuuB-4dibA:
undetectable
4uuuB-4dibA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ebz CHITIN ELICITOR
RECEPTOR KINASE 1


(Arabidopsis
thaliana)
PF01476
(LysM)
5 PHE A 201
ASP A 176
ALA A 182
VAL A 210
ILE A 207
None
1.30A 4uuuB-4ebzA:
undetectable
4uuuB-4ebzA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esy CBS DOMAIN
CONTAINING MEMBRANE
PROTEIN


(Sphaerobacter
thermophilus)
PF00571
(CBS)
5 SER A 321
ALA A 347
PRO A 348
THR A 447
ASP A 450
None
None
None
CL  A 502 (-4.1A)
None
0.78A 4uuuB-4esyA:
14.2
4uuuB-4esyA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1


(Saccharomyces
cerevisiae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 PHE A 370
ASP A 367
VAL A 251
THR A 223
ILE A 224
None
1.10A 4uuuB-4g1pA:
undetectable
4uuuB-4g1pA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
5 ASP A 225
ALA A 253
VAL A 181
THR A 185
ILE A 189
None
1.14A 4uuuB-4gp1A:
undetectable
4uuuB-4gp1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE


(Pyrobaculum
calidifontis)
PF00348
(polyprenyl_synt)
5 ASP A 225
GLN A 222
VAL A 181
THR A 185
ILE A 189
None
1.31A 4uuuB-4gp1A:
undetectable
4uuuB-4gp1A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqy CBS
DOMAIN-CONTAINING
PROTEIN CBSX2,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00571
(CBS)
5 LEU A 182
PHE A 202
PRO A 206
VAL A 125
ASP A 130
AMP  A 301 (-4.3A)
AMP  A 301 (-3.5A)
AMP  A 301 (-4.6A)
AMP  A 301 (-4.5A)
AMP  A 301 (-2.8A)
1.06A 4uuuB-4gqyA:
14.6
4uuuB-4gqyA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxe PUTATIVE
UNCHARACTERIZED
PROTEIN PH0594


(Pyrococcus
horikoshii)
PF00326
(Peptidase_S9)
PF07676
(PD40)
5 LEU B 427
ASP B 437
ALA B 426
ILE B 359
ASP B 360
HEZ  B 705 ( 4.5A)
None
None
None
None
1.26A 4uuuB-4hxeB:
undetectable
4uuuB-4hxeB:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4z NAPHTHOATE SYNTHASE

(Synechocystis
sp. PCC 6803)
PF00378
(ECH_1)
5 LEU A 222
PHE A 226
ASP A 229
ALA A 225
ILE A 164
None
1.22A 4uuuB-4i4zA:
undetectable
4uuuB-4i4zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jat ALPHA-PYRONE
SYNTHESIS POLYKETIDE
SYNTHASE-LIKE PKS11


(Mycobacterium
tuberculosis)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 LEU A  84
ASP A  78
ALA A  83
VAL A 165
ILE A  73
None
1.25A 4uuuB-4jatA:
undetectable
4uuuB-4jatA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k05 CONSERVED
HYPOTHETICAL
EXPORTED PROTEIN


(Bacteroides
fragilis)
PF07075
(DUF1343)
5 LEU A 276
PHE A 369
ASP A 370
ALA A 372
THR A 360
None
1.19A 4uuuB-4k05A:
undetectable
4uuuB-4k05A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
no annotation 5 ALA B 446
PRO B 447
VAL B 533
ILE B 537
ASP B 538
None
0.91A 4uuuB-4l27B:
17.6
4uuuB-4l27B:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
no annotation 5 PRO B 447
VAL B 533
THR B 535
ILE B 537
ASP B 538
None
0.64A 4uuuB-4l27B:
17.6
4uuuB-4l27B:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l27 CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
no annotation 5 SER B 420
LEU B 423
PHE B 443
ALA B 446
PRO B 447
None
0.97A 4uuuB-4l27B:
17.6
4uuuB-4l27B:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk2 PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN


(Rhizobium etli)
PF01547
(SBP_bac_1)
5 SER A 354
LEU A 348
ALA A 347
THR A 268
ILE A 150
None
1.32A 4uuuB-4rk2A:
undetectable
4uuuB-4rk2A:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uuu CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
PF00571
(CBS)
10 LEU A 423
PHE A 443
ASP A 444
GLN A 445
ALA A 446
PRO A 447
VAL A 533
THR A 535
ILE A 537
ASP A 538
SAM  A1546 (-4.5A)
SAM  A1546 (-3.5A)
SAM  A1546 ( 3.2A)
SAM  A1546 (-3.0A)
SAM  A1546 ( 3.7A)
None
SAM  A1546 (-4.5A)
SAM  A1546 (-2.9A)
None
SAM  A1546 ( 2.9A)
0.15A 4uuuB-4uuuA:
21.4
4uuuB-4uuuA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uuu CYSTATHIONINE
BETA-SYNTHASE


(Homo sapiens)
PF00571
(CBS)
7 SER A 420
LEU A 423
ALA A 446
PRO A 447
VAL A 533
ILE A 537
ASP A 538
EDO  A1547 (-2.7A)
SAM  A1546 (-4.5A)
SAM  A1546 ( 3.7A)
None
SAM  A1546 (-4.5A)
None
SAM  A1546 ( 2.9A)
0.72A 4uuuB-4uuuA:
21.4
4uuuB-4uuuA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7x MDBA

(Actinomyces
oris)
PF13462
(Thioredoxin_4)
5 ASP A 159
ALA A 128
PRO A 129
VAL A 293
THR A 290
None
1.30A 4uuuB-4z7xA:
undetectable
4uuuB-4z7xA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9g GLYCERALDEHYDE-3-P
DEHYDROGENASE


(Lactobacillus
acidophilus)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 155
LEU A 161
PRO A 163
VAL A 136
THR A 134
None
1.20A 4uuuB-5j9gA:
undetectable
4uuuB-5j9gA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN


(Methanocaldococcus
jannaschii)
PF00814
(Peptidase_M22)
5 LEU A 126
GLN A 134
VAL A 145
THR A 316
ILE A 108
None
1.19A 4uuuB-5jmvA:
undetectable
4uuuB-5jmvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kk5 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1


(Acidaminococcus
sp. BV3L6)
no annotation 5 LEU A1182
ASP A1112
ALA A1179
PRO A1178
VAL A1222
None
1.29A 4uuuB-5kk5A:
undetectable
4uuuB-5kk5A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF03971
(IDH)
5 SER A  89
ALA A 589
PRO A 590
THR A  13
ILE A  44
MLT  A 802 ( 3.0A)
NAP  A 801 (-4.0A)
NAP  A 801 (-4.6A)
None
None
1.28A 4uuuB-5kvuA:
undetectable
4uuuB-5kvuA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S5
30S RIBOSOMAL
PROTEIN S8


(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
PF00410
(Ribosomal_S8)
5 LEU H 101
ALA E 190
PRO E 191
THR H 114
ILE H  39
None
1.20A 4uuuB-5o5jH:
undetectable
4uuuB-5o5jH:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5j 30S RIBOSOMAL
PROTEIN S5
30S RIBOSOMAL
PROTEIN S8


(Mycolicibacterium
smegmatis;
Mycolicibacterium
smegmatis)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
PF00410
(Ribosomal_S8)
5 LEU H 101
ALA E 190
PRO E 191
THR H 114
ILE H 105
None
1.17A 4uuuB-5o5jH:
undetectable
4uuuB-5o5jH:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii)
no annotation 5 ALA A 542
PRO A 543
VAL A 504
THR A 506
ILE A 425
None
1.27A 4uuuB-5oc1A:
undetectable
4uuuB-5oc1A:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X


(Streptococcus
thermophilus)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA)
5 SER A 627
LEU A 624
PRO A 273
THR A 268
ILE A 486
None
1.26A 4uuuB-5u47A:
undetectable
4uuuB-5u47A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Naegleria
gruberi)
no annotation 5 SER A 148
LEU A 154
PRO A 156
VAL A 129
THR A 127
OCS  A 149 ( 3.5A)
None
None
None
PGE  A 402 (-4.7A)
1.23A 4uuuB-5ur0A:
undetectable
4uuuB-5ur0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Neisseria
gonorrhoeae)
PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C)
5 SER A 150
LEU A 156
PRO A 158
VAL A 131
THR A 129
None
1.27A 4uuuB-5vmtA:
undetectable
4uuuB-5vmtA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao9 BACTERIO-RHODOPSIN/G
UANYLYL CYCLASE 1
FUSION PROTEIN


(Blastocladiella
emersonii)
no annotation 5 SER A 456
PHE A 523
ASP A 526
ALA A 520
ILE A 531
None
1.31A 4uuuB-6ao9A:
undetectable
4uuuB-6ao9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bym STEROL-BINDING
PROTEIN


(Saccharomyces
cerevisiae)
no annotation 5 LEU A 104
GLN A 178
VAL A 136
THR A 156
ILE A 155
HC3  A 301 ( 4.6A)
HC3  A 301 ( 3.4A)
HC3  A 301 ( 4.2A)
None
None
1.32A 4uuuB-6bymA:
undetectable
4uuuB-6bymA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cn7 AEROBACTIN SYNTHASE
IUCC


(Klebsiella
pneumoniae)
no annotation 5 ASP A 271
GLN A 255
ALA A 254
PRO A 158
ASP A 442
None
1.29A 4uuuB-6cn7A:
undetectable
4uuuB-6cn7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-)
no annotation 5 SER A  88
ALA A 586
PRO A 587
THR A  12
ILE A  43
AKG  A 802 ( 3.0A)
NAP  A 801 (-4.2A)
NAP  A 801 (-4.3A)
None
None
1.31A 4uuuB-6g3uA:
undetectable
4uuuB-6g3uA:
undetectable