SIMILAR PATTERNS OF AMINO ACIDS FOR 4UUU_B_SAMB1548_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dbv | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Geobacillusstearothermophilus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER O 148LEU O 154PRO O 156VAL O 129THR O 127 | SO4 O 339 (-2.9A)NoneNoneNoneNone | 1.14A | 4uuuB-1dbvO:undetectable | 4uuuB-1dbvO:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e1c | METHYLMALONYL-COAMUTASE ALPHA CHAIN (Propionibacteriumfreudenreichii) |
PF01642(MM_CoA_mutase)PF02310(B12-binding) | 5 | SER A 656ALA A 373VAL A 687THR A 706ILE A 704 | NoneB12 A 800 (-4.5A)B12 A 800 (-4.6A)NoneNone | 1.26A | 4uuuB-1e1cA:0.0 | 4uuuB-1e1cA:11.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fba | FRUCTOSE1,6-BISPHOSPHATEALDOLASE (Drosophilamelanogaster) |
PF00274(Glycolytic) | 5 | LEU A 356GLN A 306ALA A 307ILE A 77ASP A 33 | None | 1.23A | 4uuuB-1fbaA:0.0 | 4uuuB-1fbaA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gyq | PROTEIN(GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE) (Leishmaniamexicana) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 165LEU A 171PRO A 173VAL A 145THR A 143 | None | 1.22A | 4uuuB-1gyqA:undetectable | 4uuuB-1gyqA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hwp | EBULIN (Sambucus ebulus) |
PF00652(Ricin_B_lectin) | 5 | SER B 73LEU B 118GLN B 129ALA B 109PRO B 110 | None | 1.05A | 4uuuB-1hwpB:undetectable | 4uuuB-1hwpB:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ihm | CAPSID PROTEIN (Norwalk virus) |
PF00915(Calici_coat)PF08435(Calici_coat_C) | 5 | LEU A1373ALA A1246PRO A1247VAL A1287THR A1280 | None | 1.33A | 4uuuB-1ihmA:0.0 | 4uuuB-1ihmA:14.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 5 | SER A 87ALA A 586PRO A 587THR A 11ILE A 42 | NAP A1000 (-4.1A)NAP A1000 (-3.8A)NAP A1000 (-4.6A)NoneNone | 1.26A | 4uuuB-1j1wA:undetectable | 4uuuB-1j1wA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jn0 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASEA (Spinaciaoleracea) |
no annotation | 5 | SER O 148LEU O 154PRO O 156VAL O 129THR O 127 | SO4 O6337 (-3.5A)NoneNoneNoneNone | 1.19A | 4uuuB-1jn0O:undetectable | 4uuuB-1jn0O:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfi | PHOSPHOGLUCOMUTASE 1 (Parameciumtetraurelia) |
PF00408(PGM_PMM_IV)PF02878(PGM_PMM_I)PF02879(PGM_PMM_II)PF02880(PGM_PMM_III) | 5 | SER A 103LEU A 97ALA A 95VAL A 92ILE A 121 | None | 1.17A | 4uuuB-1kfiA:0.0 | 4uuuB-1kfiA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kfu | M-CALPAIN LARGESUBUNIT (Homo sapiens) |
PF00648(Peptidase_C2)PF01067(Calpain_III)PF13833(EF-hand_8) | 5 | LEU L 166ASP L 104GLN L 99ALA L 101ILE L 111 | None | 1.28A | 4uuuB-1kfuL:undetectable | 4uuuB-1kfuL:11.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kri | VP4 (Rotavirus A) |
PF00426(VP4_haemagglut) | 5 | LEU A 164ALA A 85PRO A 86THR A 105ASP A 142 | None | 1.17A | 4uuuB-1kriA:undetectable | 4uuuB-1kriA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5x | SURVIVAL PROTEIN E (Pyrobaculumaerophilum) |
PF01975(SurE) | 5 | ALA A 122PRO A 121VAL A 156THR A 152ILE A 262 | None | 1.13A | 4uuuB-1l5xA:undetectable | 4uuuB-1l5xA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m2p | CASEIN KINASE II,ALPHA CHAIN (Zea mays) |
PF00069(Pkinase) | 5 | SER A 294LEU A 301PHE A 222ALA A 223ASP A 130 | None | 1.29A | 4uuuB-1m2pA:undetectable | 4uuuB-1m2pA:17.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nd4 | AMINOGLYCOSIDE3'-PHOSPHOTRANSFERASE (Klebsiellapneumoniae) |
PF01636(APH) | 5 | LEU A 241ASP A 227ALA A 237VAL A 113ILE A 196 | NoneKAN A1300 (-3.8A)NoneNoneNone | 1.23A | 4uuuB-1nd4A:undetectable | 4uuuB-1nd4A:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svd | RIBULOSE-1,5-BISPHOSPHATECARBOXYLASE/OXYGENASE LARGE SUBUNIT (Halothiobacillusneapolitanus) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | LEU A 383GLN A 394ALA A 371VAL A 392ASP A 191 | None | 1.28A | 4uuuB-1svdA:undetectable | 4uuuB-1svdA:15.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1woq | INORGANICPOLYPHOSPHATE/ATP-GLUCOMANNOKINASE (Arthrobactersp. KM) |
PF00480(ROK) | 5 | LEU A 163ASP A 123VAL A 146THR A 148ILE A 153 | NoneBGC A 290 (-2.9A)NoneNoneNone | 1.33A | 4uuuB-1woqA:undetectable | 4uuuB-1woqA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xqw | PROLINEIMINOPEPTIDASE (Thermoplasmaacidophilum) |
PF00561(Abhydrolase_1) | 5 | LEU A 110ALA A 109VAL A 127THR A 236ILE A 234 | None | 1.25A | 4uuuB-1xqwA:undetectable | 4uuuB-1xqwA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb5 | QUINONEOXIDOREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | LEU A 117PHE A 94ASP A 72ALA A 74THR A 113 | NoneNoneNoneNone CL A 818 (-3.2A) | 1.26A | 4uuuB-1yb5A:undetectable | 4uuuB-1yb5A:24.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3i | SIMILAR TORAD54-LIKE (Danio rerio) |
PF00176(SNF2_N)PF00271(Helicase_C) | 5 | SER X 446LEU X 417PHE X 468ASP X 469GLN X 424 | None | 1.25A | 4uuuB-1z3iX:undetectable | 4uuuB-1z3iX:13.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ayi | AMINOPEPTIDASE T (Thermusthermophilus) |
PF02073(Peptidase_M29) | 5 | PHE A 39ALA A 36PRO A 33VAL A 101ILE A 16 | None | 1.27A | 4uuuB-2ayiA:undetectable | 4uuuB-2ayiA:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d2i | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Synechococcussp.) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 154LEU A 160PRO A 162VAL A 134THR A 132 | SO4 A1339 (-2.9A)NoneNoneNoneNone | 1.17A | 4uuuB-2d2iA:undetectable | 4uuuB-2d2iA:19.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e1t | ACYL TRANSFERASE (Chrysanthemum xmorifolium) |
PF02458(Transferase) | 5 | LEU A 345GLN A 296ALA A 328THR A 382ILE A 416 | None | 1.17A | 4uuuB-2e1tA:undetectable | 4uuuB-2e1tA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ep7 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Aquifexaeolicus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 151LEU A 157PRO A 159VAL A 131THR A 129 | None | 1.19A | 4uuuB-2ep7A:undetectable | 4uuuB-2ep7A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f3o | PYRUVATEFORMATE-LYASE 2 (Archaeoglobusfulgidus) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | SER A 754LEU A 364ASP A 360VAL A 369ILE A 389 | None | 1.30A | 4uuuB-2f3oA:undetectable | 4uuuB-2f3oA:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ics | ADENINE DEAMINASE (Enterococcusfaecalis) |
PF01979(Amidohydro_1) | 5 | LEU A 200PHE A 231ASP A 230GLN A 234ALA A 235 | None | 1.28A | 4uuuB-2icsA:undetectable | 4uuuB-2icsA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivf | ETHYLBENZENEDEHYDROGENASEALPHA-SUBUNIT (Aromatoleumaromaticum) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | ASP A 284GLN A 915VAL A 300ILE A 281ASP A 303 | MGD A1986 (-3.0A)NoneMGD A1986 ( 4.0A)MGD A1986 (-4.1A)MGD A1986 (-2.9A) | 1.28A | 4uuuB-2ivfA:undetectable | 4uuuB-2ivfA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivf | ETHYLBENZENEDEHYDROGENASEALPHA-SUBUNIT (Aromatoleumaromaticum) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | SER A 451ASP A 284GLN A 915VAL A 300ASP A 303 | MGD A1986 (-4.5A)MGD A1986 (-3.0A)NoneMGD A1986 ( 4.0A)MGD A1986 (-2.9A) | 1.25A | 4uuuB-2ivfA:undetectable | 4uuuB-2ivfA:9.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n8a | POLY [ADP-RIBOSE]POLYMERASE 1 (Homo sapiens) |
PF00645(zf-PARP) | 5 | SER A 177LEU A 195PHE A 184ALA A 115THR A 109 | None | 1.03A | 4uuuB-2n8aA:undetectable | 4uuuB-2n8aA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nad | NAD-DEPENDENTFORMATEDEHYDROGENASE (Pseudomonas sp.101) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 373ASP A 125VAL A 139THR A 119ILE A 122 | NoneNoneNoneNoneNAD A 394 ( 3.5A) | 1.32A | 4uuuB-2nadA:undetectable | 4uuuB-2nadA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oqc | PENICILLIN V ACYLASE (Bacillussubtilis) |
PF02275(CBAH) | 5 | LEU A 4ALA A 16THR A 276ILE A 261ASP A 20 | None | 1.26A | 4uuuB-2oqcA:undetectable | 4uuuB-2oqcA:19.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pkq | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASEB (Spinaciaoleracea) |
PF00044(Gp_dh_N)PF02672(CP12)PF02800(Gp_dh_C) | 5 | SER O 148LEU O 154PRO O 156VAL O 129THR O 127 | None | 1.20A | 4uuuB-2pkqO:undetectable | 4uuuB-2pkqO:17.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q27 | OXALYL-COADECARBOXYLASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 67ALA A 433THR A 25ILE A 23ASP A 24 | None | 1.20A | 4uuuB-2q27A:undetectable | 4uuuB-2q27A:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q5o | PHENYLPYRUVATEDECARBOXYLASE (Azospirillumbrasilense) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | LEU A 3ALA A 141PRO A 142VAL A 175ASP A 13 | None | 1.30A | 4uuuB-2q5oA:undetectable | 4uuuB-2q5oA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2quy | PENICILLIN ACYLASE (Lysinibacillussphaericus) |
PF02275(CBAH) | 5 | LEU A 4ALA A 16THR A 276ILE A 261ASP A 20 | None | 1.20A | 4uuuB-2quyA:undetectable | 4uuuB-2quyA:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v0s | LR1 (Homo sapiens) |
PF03372(Exo_endo_phos) | 5 | LEU A 112ASP A 145GLN A 42THR A 12ILE A 231 | NoneGOL A1240 (-2.7A)NoneNoneNone | 1.21A | 4uuuB-2v0sA:undetectable | 4uuuB-2v0sA:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vwb | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22)PF01163(RIO1) | 5 | LEU A 126GLN A 134VAL A 145THR A 316ILE A 108 | None | 1.21A | 4uuuB-2vwbA:undetectable | 4uuuB-2vwbA:13.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x0n | GLYCERALDEHYDE-3-PHOSPHATEDEHYDROGENASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 164LEU A 170PRO A 172VAL A 144THR A 142 | SO4 A 360 (-2.6A)NoneNoneNoneNone | 1.26A | 4uuuB-2x0nA:undetectable | 4uuuB-2x0nA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xw7 | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
PF01872(RibD_C) | 5 | ALA A 102VAL A 1THR A 3ILE A 127ASP A 128 | None | 1.15A | 4uuuB-2xw7A:undetectable | 4uuuB-2xw7A:26.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3akc | CYTIDYLATE KINASE (Thermusthermophilus) |
PF02224(Cytidylate_kin) | 5 | LEU A 43PHE A 42ALA A 39VAL A 93THR A 90 | None | 1.25A | 4uuuB-3akcA:undetectable | 4uuuB-3akcA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b20 | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE(NADP+) (Synechococcuselongatus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 154LEU A 160PRO A 162VAL A 134THR A 132 | SO4 A1339 (-2.7A)NoneNoneNoneNone | 1.20A | 4uuuB-3b20A:undetectable | 4uuuB-3b20A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c9p | UNCHARACTERIZEDPROTEIN SP1917 (Streptococcuspneumoniae) |
PF09966(DUF2200) | 5 | PHE A 59ASP A 58GLN A 62ALA A 63PRO A 64 | None | 1.18A | 4uuuB-3c9pA:undetectable | 4uuuB-3c9pA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clm | TRANSALDOLASE (Neisseriagonorrhoeae) |
PF00923(TAL_FSA) | 5 | LEU A 164ALA A 198THR A 41ILE A 46ASP A 17 | NoneNoneNoneNoneEDO A 354 (-2.8A) | 1.24A | 4uuuB-3clmA:undetectable | 4uuuB-3clmA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dbo | UNCHARACTERIZEDPROTEINUNCHARACTERIZEDPROTEIN (Mycobacteriumtuberculosis;Mycobacteriumtuberculosis) |
PF02604(PhdYeFM_antitox)PF01850(PIN) | 5 | SER B 80LEU B 75ASP A 71GLN B 73ALA B 72 | None | 1.29A | 4uuuB-3dboB:undetectable | 4uuuB-3dboB:24.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djc | TYPE IIIPANTOTHENATE KINASE (Legionellapneumophila) |
PF03309(Pan_kinase) | 5 | ASP A 108ALA A 113VAL A 127THR A 135ILE A 150 | None | 1.27A | 4uuuB-3djcA:undetectable | 4uuuB-3djcA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ezx | MONOMETHYLAMINECORRINOID PROTEIN 1 (Methanosarcinabarkeri) |
PF02310(B12-binding)PF02607(B12-binding_2) | 5 | LEU A 213PHE A 122ALA A 209THR A 98ILE A 97 | None | 1.25A | 4uuuB-3ezxA:undetectable | 4uuuB-3ezxA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fby | CARTILAGE OLIGOMERICMATRIX PROTEIN (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C) | 5 | ASP A 595GLN A 729ALA A 597VAL A 588ASP A 678 | CA A 829 ( 2.4A)NoneNoneNone CA A 828 (-2.6A) | 1.25A | 4uuuB-3fbyA:undetectable | 4uuuB-3fbyA:13.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fk5 | 3-OXOACYL-SYNTHASEIII (Xanthomonasoryzae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ASP A 149ALA A 69VAL A 104THR A 100ASP A 94 | None | 1.13A | 4uuuB-3fk5A:undetectable | 4uuuB-3fk5A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmx | TARTRATEDEHYDROGENASE/DECARBOXYLASE (Pseudomonasputida) |
PF00180(Iso_dh) | 5 | SER X 189PHE X 176ASP X 177VAL X 240ILE X 171 | None | 0.96A | 4uuuB-3fmxX:undetectable | 4uuuB-3fmxX:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hba | PUTATIVEPHOSPHOSUGARISOMERASE (Shewanelladenitrificans) |
PF01380(SIS) | 5 | ASP A 104GLN A 108ALA A 109VAL A 47ASP A 53 | None | 1.11A | 4uuuB-3hbaA:undetectable | 4uuuB-3hbaA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hja | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Borreliellaburgdorferi) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 152LEU A 158PRO A 160VAL A 133THR A 131 | SO4 A 336 (-3.2A)NoneNoneNoneNone | 1.15A | 4uuuB-3hjaA:undetectable | 4uuuB-3hjaA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iom | PURINE NUCLEOSIDEPHOSPHORYLASE (Mycobacteriumtuberculosis) |
PF01048(PNP_UDP_1) | 5 | LEU A 142ASP A 138ALA A 181VAL A 210THR A 213 | None | 1.16A | 4uuuB-3iomA:undetectable | 4uuuB-3iomA:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jb4 | VP0 (Parechovirus B) |
PF00073(Rhv) | 5 | PHE B 115ALA B 123PRO B 122VAL B 89ILE B 235 | None | 1.26A | 4uuuB-3jb4B:undetectable | 4uuuB-3jb4B:16.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2b | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASEA, CHLOROPLASTIC (Arabidopsisthaliana) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 148LEU A 154PRO A 156VAL A 129THR A 127 | SO4 A 337 (-3.1A)NoneNoneNoneNone | 1.25A | 4uuuB-3k2bA:undetectable | 4uuuB-3k2bA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l0d | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Bartonellahenselae) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 152LEU A 158PRO A 160VAL A 133THR A 131 | None | 1.18A | 4uuuB-3l0dA:undetectable | 4uuuB-3l0dA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m1g | PUTATIVE GLUTATHIONES-TRANSFERASE (Corynebacteriumglutamicum) |
PF13409(GST_N_2)PF13410(GST_C_2) | 5 | LEU A 80ALA A 170PRO A 171ILE A 345ASP A 288 | None | 1.23A | 4uuuB-3m1gA:undetectable | 4uuuB-3m1gA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mae | 2-OXOISOVALERATEDEHYDROGENASE E2COMPONENT,DIHYDROLIPOAMIDEACETYLTRANSFERASE (Listeriamonocytogenes) |
PF00198(2-oxoacid_dh) | 5 | LEU A 262PHE A 331GLN A 352ALA A 353ILE A 294 | None | 1.28A | 4uuuB-3maeA:undetectable | 4uuuB-3maeA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mjf | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Yersinia pestis) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | ALA A 50PRO A 75VAL A 70THR A 68ILE A 3 | None | 1.31A | 4uuuB-3mjfA:undetectable | 4uuuB-3mjfA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ne5 | CATION EFFLUX SYSTEMPROTEIN CUSA (Escherichiacoli) |
PF00873(ACR_tran) | 5 | LEU A 357ASP A 405ALA A 366VAL A 349ILE A 992 | None | 1.19A | 4uuuB-3ne5A:undetectable | 4uuuB-3ne5A:9.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ntd | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE (Shewanellaloihica) |
PF00581(Rhodanese)PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | LEU A 399ASP A 455ALA A 461VAL A 380THR A 382 | None | 1.23A | 4uuuB-3ntdA:undetectable | 4uuuB-3ntdA:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o2k | BREVIANAMIDE FPRENYLTRANSFERASE (Aspergillusfumigatus) |
PF11991(Trp_DMAT) | 5 | LEU A 68ALA A 72PRO A 71THR A 40ILE A 43 | NoneNoneMES A 475 ( 4.9A)NoneNone | 1.30A | 4uuuB-3o2kA:undetectable | 4uuuB-3o2kA:17.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p19 | PUTATIVE BLUEFLUORESCENT PROTEIN (Vibriovulnificus) |
PF00106(adh_short) | 5 | SER A 11LEU A 32GLN A 51ALA A 50VAL A 36 | NDP A2001 ( 2.7A)NoneNoneNoneNone | 1.29A | 4uuuB-3p19A:undetectable | 4uuuB-3p19A:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pc3 | CG1753, ISOFORM A (Drosophilamelanogaster) |
PF00291(PALP)PF00571(CBS) | 5 | ASP A 412GLN A 413PRO A 415THR A 496ASP A 499 | None | 0.73A | 4uuuB-3pc3A:10.3 | 4uuuB-3pc3A:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9s | DNA-BINDING RESPONSEREGULATOR (Deinococcusradiodurans) |
PF00072(Response_reg)PF00486(Trans_reg_C) | 5 | SER A 150ASP A 99GLN A 117ILE A 177ASP A 155 | None | 1.19A | 4uuuB-3q9sA:undetectable | 4uuuB-3q9sA:25.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rxz | POLYSACCHARIDEDEACETYLASE (Mycolicibacteriumsmegmatis) |
PF01522(Polysacc_deac_1) | 5 | LEU A 167PRO A 187VAL A 188THR A 237ASP A 193 | None | 1.30A | 4uuuB-3rxzA:undetectable | 4uuuB-3rxzA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3teb | ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE (Leptotrichiabuccalis) |
PF03372(Exo_endo_phos) | 5 | PHE A 174ASP A 173GLN A 38THR A 5ILE A 257 | None | 1.16A | 4uuuB-3tebA:undetectable | 4uuuB-3tebA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zdf | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Thermosynechococcuselongatus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 153LEU A 159PRO A 161VAL A 134THR A 132 | None | 1.17A | 4uuuB-3zdfA:undetectable | 4uuuB-3zdfA:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4arp | PESTICIN (Yersinia pestis) |
PF16754(Pesticin) | 5 | LEU A 346ASP A 352GLN A 348ALA A 345VAL A 326 | None | 1.24A | 4uuuB-4arpA:undetectable | 4uuuB-4arpA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c2k | 3-KETOACYL-COATHIOLASE,MITOCHONDRIAL (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | LEU A 60GLN A 124ALA A 125PRO A 126ASP A 65 | None | 1.23A | 4uuuB-4c2kA:undetectable | 4uuuB-4c2kA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dib | GLYCERALDEHYDE3-PHOSPHATEDEHYDROGENASE (Bacillusanthracis) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 150LEU A 156PRO A 158VAL A 130THR A 128 | None | 1.14A | 4uuuB-4dibA:undetectable | 4uuuB-4dibA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ebz | CHITIN ELICITORRECEPTOR KINASE 1 (Arabidopsisthaliana) |
PF01476(LysM) | 5 | PHE A 201ASP A 176ALA A 182VAL A 210ILE A 207 | None | 1.30A | 4uuuB-4ebzA:undetectable | 4uuuB-4ebzA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4esy | CBS DOMAINCONTAINING MEMBRANEPROTEIN (Sphaerobacterthermophilus) |
PF00571(CBS) | 5 | SER A 321ALA A 347PRO A 348THR A 447ASP A 450 | NoneNoneNone CL A 502 (-4.1A)None | 0.78A | 4uuuB-4esyA:14.2 | 4uuuB-4esyA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g1p | CYS-GLYMETALLODIPEPTIDASEDUG1 (Saccharomycescerevisiae) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | PHE A 370ASP A 367VAL A 251THR A 223ILE A 224 | None | 1.10A | 4uuuB-4g1pA:undetectable | 4uuuB-4g1pA:16.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 5 | ASP A 225ALA A 253VAL A 181THR A 185ILE A 189 | None | 1.14A | 4uuuB-4gp1A:undetectable | 4uuuB-4gp1A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gp1 | POLYPRENYLSYNTHETASE (Pyrobaculumcalidifontis) |
PF00348(polyprenyl_synt) | 5 | ASP A 225GLN A 222VAL A 181THR A 185ILE A 189 | None | 1.31A | 4uuuB-4gp1A:undetectable | 4uuuB-4gp1A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gqy | CBSDOMAIN-CONTAININGPROTEIN CBSX2,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00571(CBS) | 5 | LEU A 182PHE A 202PRO A 206VAL A 125ASP A 130 | AMP A 301 (-4.3A)AMP A 301 (-3.5A)AMP A 301 (-4.6A)AMP A 301 (-4.5A)AMP A 301 (-2.8A) | 1.06A | 4uuuB-4gqyA:14.6 | 4uuuB-4gqyA:24.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hxe | PUTATIVEUNCHARACTERIZEDPROTEIN PH0594 (Pyrococcushorikoshii) |
PF00326(Peptidase_S9)PF07676(PD40) | 5 | LEU B 427ASP B 437ALA B 426ILE B 359ASP B 360 | HEZ B 705 ( 4.5A)NoneNoneNoneNone | 1.26A | 4uuuB-4hxeB:undetectable | 4uuuB-4hxeB:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4z | NAPHTHOATE SYNTHASE (Synechocystissp. PCC 6803) |
PF00378(ECH_1) | 5 | LEU A 222PHE A 226ASP A 229ALA A 225ILE A 164 | None | 1.22A | 4uuuB-4i4zA:undetectable | 4uuuB-4i4zA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jat | ALPHA-PYRONESYNTHESIS POLYKETIDESYNTHASE-LIKE PKS11 (Mycobacteriumtuberculosis) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | LEU A 84ASP A 78ALA A 83VAL A 165ILE A 73 | None | 1.25A | 4uuuB-4jatA:undetectable | 4uuuB-4jatA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k05 | CONSERVEDHYPOTHETICALEXPORTED PROTEIN (Bacteroidesfragilis) |
PF07075(DUF1343) | 5 | LEU A 276PHE A 369ASP A 370ALA A 372THR A 360 | None | 1.19A | 4uuuB-4k05A:undetectable | 4uuuB-4k05A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l27 | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
no annotation | 5 | ALA B 446PRO B 447VAL B 533ILE B 537ASP B 538 | None | 0.91A | 4uuuB-4l27B:17.6 | 4uuuB-4l27B:27.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l27 | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
no annotation | 5 | PRO B 447VAL B 533THR B 535ILE B 537ASP B 538 | None | 0.64A | 4uuuB-4l27B:17.6 | 4uuuB-4l27B:27.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l27 | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
no annotation | 5 | SER B 420LEU B 423PHE B 443ALA B 446PRO B 447 | None | 0.97A | 4uuuB-4l27B:17.6 | 4uuuB-4l27B:27.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk2 | PUTATIVE SUGAR ABCTRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Rhizobium etli) |
PF01547(SBP_bac_1) | 5 | SER A 354LEU A 348ALA A 347THR A 268ILE A 150 | None | 1.32A | 4uuuB-4rk2A:undetectable | 4uuuB-4rk2A:16.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uuu | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
PF00571(CBS) | 10 | LEU A 423PHE A 443ASP A 444GLN A 445ALA A 446PRO A 447VAL A 533THR A 535ILE A 537ASP A 538 | SAM A1546 (-4.5A)SAM A1546 (-3.5A)SAM A1546 ( 3.2A)SAM A1546 (-3.0A)SAM A1546 ( 3.7A)NoneSAM A1546 (-4.5A)SAM A1546 (-2.9A)NoneSAM A1546 ( 2.9A) | 0.15A | 4uuuB-4uuuA:21.4 | 4uuuB-4uuuA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4uuu | CYSTATHIONINEBETA-SYNTHASE (Homo sapiens) |
PF00571(CBS) | 7 | SER A 420LEU A 423ALA A 446PRO A 447VAL A 533ILE A 537ASP A 538 | EDO A1547 (-2.7A)SAM A1546 (-4.5A)SAM A1546 ( 3.7A)NoneSAM A1546 (-4.5A)NoneSAM A1546 ( 2.9A) | 0.72A | 4uuuB-4uuuA:21.4 | 4uuuB-4uuuA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7x | MDBA (Actinomycesoris) |
PF13462(Thioredoxin_4) | 5 | ASP A 159ALA A 128PRO A 129VAL A 293THR A 290 | None | 1.30A | 4uuuB-4z7xA:undetectable | 4uuuB-4z7xA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j9g | GLYCERALDEHYDE-3-PDEHYDROGENASE (Lactobacillusacidophilus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 155LEU A 161PRO A 163VAL A 136THR A 134 | None | 1.20A | 4uuuB-5j9gA:undetectable | 4uuuB-5j9gA:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jmv | PROBABLEBIFUNCTIONAL TRNATHREONYLCARBAMOYLADENOSINE BIOSYNTHESISPROTEIN (Methanocaldococcusjannaschii) |
PF00814(Peptidase_M22) | 5 | LEU A 126GLN A 134VAL A 145THR A 316ILE A 108 | None | 1.19A | 4uuuB-5jmvA:undetectable | 4uuuB-5jmvA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kk5 | CRISPR-ASSOCIATEDENDONUCLEASE CPF1 (Acidaminococcussp. BV3L6) |
no annotation | 5 | LEU A1182ASP A1112ALA A1179PRO A1178VAL A1222 | None | 1.29A | 4uuuB-5kk5A:undetectable | 4uuuB-5kk5A:8.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kvu | ISOCITRATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF03971(IDH) | 5 | SER A 89ALA A 589PRO A 590THR A 13ILE A 44 | MLT A 802 ( 3.0A)NAP A 801 (-4.0A)NAP A 801 (-4.6A)NoneNone | 1.28A | 4uuuB-5kvuA:undetectable | 4uuuB-5kvuA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5j | 30S RIBOSOMALPROTEIN S530S RIBOSOMALPROTEIN S8 (Mycolicibacteriumsmegmatis;Mycolicibacteriumsmegmatis) |
PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C)PF00410(Ribosomal_S8) | 5 | LEU H 101ALA E 190PRO E 191THR H 114ILE H 39 | None | 1.20A | 4uuuB-5o5jH:undetectable | 4uuuB-5o5jH:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o5j | 30S RIBOSOMALPROTEIN S530S RIBOSOMALPROTEIN S8 (Mycolicibacteriumsmegmatis;Mycolicibacteriumsmegmatis) |
PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C)PF00410(Ribosomal_S8) | 5 | LEU H 101ALA E 190PRO E 191THR H 114ILE H 105 | None | 1.17A | 4uuuB-5o5jH:undetectable | 4uuuB-5o5jH:23.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oc1 | ARYL-ALCOHOL OXIDASE (Pleurotuseryngii) |
no annotation | 5 | ALA A 542PRO A 543VAL A 504THR A 506ILE A 425 | None | 1.27A | 4uuuB-5oc1A:undetectable | 4uuuB-5oc1A:13.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u47 | PENICILLIN BINDINGPROTEIN 2X (Streptococcusthermophilus) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF03793(PASTA) | 5 | SER A 627LEU A 624PRO A 273THR A 268ILE A 486 | None | 1.26A | 4uuuB-5u47A:undetectable | 4uuuB-5u47A:13.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ur0 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Naegleriagruberi) |
no annotation | 5 | SER A 148LEU A 154PRO A 156VAL A 129THR A 127 | OCS A 149 ( 3.5A)NoneNoneNonePGE A 402 (-4.7A) | 1.23A | 4uuuB-5ur0A:undetectable | 4uuuB-5ur0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vmt | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Neisseriagonorrhoeae) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | SER A 150LEU A 156PRO A 158VAL A 131THR A 129 | None | 1.27A | 4uuuB-5vmtA:undetectable | 4uuuB-5vmtA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao9 | BACTERIO-RHODOPSIN/GUANYLYL CYCLASE 1FUSION PROTEIN (Blastocladiellaemersonii) |
no annotation | 5 | SER A 456PHE A 523ASP A 526ALA A 520ILE A 531 | None | 1.31A | 4uuuB-6ao9A:undetectable | 4uuuB-6ao9A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bym | STEROL-BINDINGPROTEIN (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 104GLN A 178VAL A 136THR A 156ILE A 155 | HC3 A 301 ( 4.6A)HC3 A 301 ( 3.4A)HC3 A 301 ( 4.2A)NoneNone | 1.32A | 4uuuB-6bymA:undetectable | 4uuuB-6bymA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cn7 | AEROBACTIN SYNTHASEIUCC (Klebsiellapneumoniae) |
no annotation | 5 | ASP A 271GLN A 255ALA A 254PRO A 158ASP A 442 | None | 1.29A | 4uuuB-6cn7A:undetectable | 4uuuB-6cn7A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g3u | - (-) |
no annotation | 5 | SER A 88ALA A 586PRO A 587THR A 12ILE A 43 | AKG A 802 ( 3.0A)NAP A 801 (-4.2A)NAP A 801 (-4.3A)NoneNone | 1.31A | 4uuuB-6g3uA:undetectable | 4uuuB-6g3uA:undetectable |