SIMILAR PATTERNS OF AMINO ACIDS FOR 4URO_C_NOVC2000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aj6 GYRASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		6 ASN A  46
GLU A  50
ARG A  76
PRO A  79
ALA A  91
ILE A  94
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.2A)
None
NOV  A   1 ( 4.4A)
 1.36A 4uroC-1aj6A:
28.6		 4uroC-1aj6A:
55.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aj6 GYRASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		8 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ALA A  90
ILE A  94
 NOV  A   1 (-4.0A)
NOV  A   1 (-3.8A)
NOV  A   1 (-3.5A)
NOV  A   1 (-3.5A)
NOV  A   1 (-4.1A)
NOV  A   1 (-4.2A)
NOV  A   1 ( 3.9A)
NOV  A   1 ( 4.4A)
 0.46A 4uroC-1aj6A:
28.6		 4uroC-1aj6A:
55.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 ASN A 299
ARG A 129
ASP A  98
ALA A 103
SER A 177
 None
None
None
None
LLP  A 198 ( 3.7A)
 0.98A 4uroC-1bjnA:
undetectable		 4uroC-1bjnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLU A  77
ILE A  73
ASP A  68
GLN A 311
ILE A 248
 None
 1.34A 4uroC-1bucA:
undetectable		 4uroC-1bucA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 PRO A 466
GLN A 520
ALA A 516
ILE A 514
SER A 581
 None
 1.28A 4uroC-1ciyA:
undetectable		 4uroC-1ciyA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ASP A 168
ILE A 121
PRO A 122
GLN A  77
ILE A 161
 None
 1.30A 4uroC-1f59A:
undetectable		 4uroC-1f59A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF00719
(Pyrophosphatase) 		5 GLU A  62
ILE A  59
ASP A 120
ALA A  95
SER A  27
 None
None
MG  A 282 (-2.6A)
None
None
 1.19A 4uroC-1hujA:
undetectable		 4uroC-1hujA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1id0 PHOQ HISTIDINE
KINASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		5 ASN A 389
ASP A 415
ILE A 420
PRO A 421
ILE A 428
 ANP  A 487 (-3.0A)
ANP  A 487 (-3.7A)
ANP  A 487 (-4.7A)
None
ANP  A 487 (-3.7A)
 0.60A 4uroC-1id0A:
5.9		 4uroC-1id0A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5t INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermotoga
maritima) 		PF00218
(IGPS) 		5 ARG A   5
ILE A  83
PRO A  82
ALA A  55
ILE A  56
 None
 1.26A 4uroC-1j5tA:
undetectable		 4uroC-1j5tA:
23.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kij DNA GYRASE SUBUNIT B

(Thermus
thermophilus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		10 ASN A  45
GLU A  49
ASP A  72
ARG A  75
ILE A  77
PRO A  78
ASP A  80
ALA A  89
ILE A  93
ARG A 135
 NOV  A 400 (-3.8A)
NOV  A 400 (-3.6A)
NOV  A 400 (-3.1A)
NOV  A 400 (-3.4A)
NOV  A 400 (-4.1A)
NOV  A 400 (-4.4A)
NOV  A 400 (-2.8A)
NOV  A 400 ( 4.1A)
NOV  A 400 (-4.5A)
NOV  A 400 (-2.7A)
 0.51A 4uroC-1kijA:
28.1		 4uroC-1kijA:
32.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		5 ASN A  22
ILE A 226
GLN A 234
ALA A 229
ILE A 236
 None
 0.99A 4uroC-1kqoA:
undetectable		 4uroC-1kqoA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qqj FUMARYLACETOACETATE
HYDROLASE

(Mus musculus) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		5 PRO A  18
GLN A 110
ALA A  35
ILE A  36
SER A   2
 None
 1.29A 4uroC-1qqjA:
undetectable		 4uroC-1qqjA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrd QUINONE-REDUCTASE

(Rattus rattus) 		PF02525
(Flavodoxin_2) 		5 GLU A  23
ILE A   7
ALA A   5
ILE A  98
SER A 145
 None
 1.28A 4uroC-1qrdA:
undetectable		 4uroC-1qrdA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s14 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		9 ASN A1042
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ALA A1086
ILE A1090
ARG A1132
 NOV  A1300 (-3.7A)
NOV  A1300 (-3.7A)
NOV  A1300 (-3.4A)
NOV  A1300 (-3.1A)
NOV  A1300 (-4.5A)
NOV  A1300 (-2.7A)
NOV  A1300 ( 4.3A)
NOV  A1300 ( 4.6A)
NOV  A1300 (-2.9A)
 0.54A 4uroC-1s14A:
26.0		 4uroC-1s14A:
37.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		9 ASN A1042
GLU A1046
ASP A1069
ARG A1072
PRO A1075
ASP A1077
ALA A1086
ILE A1090
ARG A1132
 ANP  A1500 (-3.2A)
ANP  A1500 (-3.7A)
ANP  A1500 (-3.5A)
None
None
None
None
ANP  A1500 ( 3.2A)
None
 0.75A 4uroC-1s16A:
25.9		 4uroC-1s16A:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttz CONSERVED
HYPOTHETICAL PROTEIN

(Xanthomonas
campestris) 		PF05768
(DUF836) 		5 GLU A  58
ASP A  60
ARG A  52
ASP A  37
ALA A  39
 None
 1.34A 4uroC-1ttzA:
undetectable		 4uroC-1ttzA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufv PANTOATE-BETA-ALANIN
E LIGASE

(Thermus
thermophilus) 		PF02569
(Pantoate_ligase) 		5 GLU A  61
ASP A  62
ALA A 260
ILE A 269
ARG A 262
 GOL  A 600 (-3.7A)
GOL  A 600 (-3.1A)
None
None
GOL  A 600 ( 4.2A)
 1.22A 4uroC-1ufvA:
undetectable		 4uroC-1ufvA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		5 ASP A 205
ILE A 405
PRO A 404
ILE A 374
SER A 270
 MDO  A 203 ( 4.3A)
None
None
None
None
 1.14A 4uroC-1w27A:
undetectable		 4uroC-1w27A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLU A 183
ILE B  62
ASP B  29
GLN B  81
ILE B  80
 None
 1.11A 4uroC-1w85A:
undetectable		 4uroC-1w85A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx6 THYMIDINE KINASE

(Clostridium
acetobutylicum) 		PF00265
(TK) 		5 ASP A  88
ILE A  29
GLN A  37
ALA A  32
ILE A  39
 None
 1.29A 4uroC-1xx6A:
undetectable		 4uroC-1xx6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1

(Borreliella
burgdorferi) 		PF02127
(Peptidase_M18) 		5 ASN A  90
ILE A  92
ASP A 256
ALA A 334
ILE A 332
 None
 1.17A 4uroC-1y7eA:
undetectable		 4uroC-1y7eA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydo HMG-COA LYASE

(Bacillus
subtilis) 		PF00682
(HMGL-like) 		5 GLU A  46
ILE A  47
ASP A  61
ILE A  34
SER A  38
 None
 1.07A 4uroC-1ydoA:
undetectable		 4uroC-1ydoA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		5 ASN A 112
GLU A 173
ALA A  39
ILE A  47
ARG A 177
 None
 1.20A 4uroC-2c1cA:
undetectable		 4uroC-2c1cA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4y FEOA-LIKE PROTEIN

(Clostridium
acetobutylicum) 		PF04023
(FeoA) 		5 ASN A   8
GLU A  69
ILE A  54
PRO A  53
ALA A  48
 None
 1.34A 4uroC-2k4yA:
undetectable		 4uroC-2k4yA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP

(Escherichia
coli) 		PF00072
(Response_reg) 		5 GLU A  57
ASP A  58
ARG A  65
ILE A  63
ILE A  75
 None
 0.82A 4uroC-2pl1A:
undetectable		 4uroC-2pl1A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptz ENOLASE

(Trypanosoma
brucei) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 ASP A 378
ILE A 344
ALA A 353
ILE A 350
SER A 117
 None
 1.28A 4uroC-2ptzA:
undetectable		 4uroC-2ptzA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzw CANDIDAPEPSIN-1

(Candida
albicans) 		PF00026
(Asp) 		5 ILE A 170
GLN A   1
ALA A   2
ILE A 338
SER A 336
 None
 1.22A 4uroC-2qzwA:
undetectable		 4uroC-2qzwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vat ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE

(Acremonium
chrysogenum) 		PF00561
(Abhydrolase_1) 		5 ILE A 295
ASP A 290
GLN A 209
ALA A 291
ILE A 193
 None
 1.25A 4uroC-2vatA:
undetectable		 4uroC-2vatA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyi LIPASE, PUTATIVE

(Archaeoglobus
fulgidus) 		PF00561
(Abhydrolase_1) 		5 ARG A 275
ILE A 456
PRO A 457
ALA A 458
ILE A 466
 None
 1.27A 4uroC-2zyiA:
undetectable		 4uroC-2zyiA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc7 PUTATIVE
UNCHARACTERIZED
PROTEIN LP_3323

(Lactobacillus
plantarum) 		PF13472
(Lipase_GDSL_2) 		5 ILE A  79
PRO A  80
ASP A  82
ALA A  83
ILE A  86
 None
 1.06A 4uroC-3dc7A:
undetectable		 4uroC-3dc7A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehq OSTEOCLAST-STIMULATI
NG FACTOR 1

(Homo sapiens) 		PF00018
(SH3_1)
PF12796
(Ank_2) 		5 ILE A  61
PRO A  62
GLN A  69
ILE A  33
SER A  54
 None
 1.28A 4uroC-3ehqA:
undetectable		 4uroC-3ehqA:
24.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		8 ASN A  42
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ALA A  86
ILE A  90
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-4.5A)
1EU  A   2 (-3.9A)
 0.63A 4uroC-3fv5A:
28.5		 4uroC-3fv5A:
46.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		7 ASN A  42
GLU A  46
ASP A  69
ARG A  72
PRO A  75
ASP A  77
ARG A 132
 1EU  A   2 (-4.9A)
1EU  A   2 (-3.4A)
1EU  A   2 (-3.3A)
1EU  A   2 (-3.3A)
1EU  A   2 (-4.2A)
None
1EU  A   2 (-3.9A)
 1.16A 4uroC-3fv5A:
28.5		 4uroC-3fv5A:
46.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hoa THERMOSTABLE
CARBOXYPEPTIDASE 1

(Thermus
thermophilus) 		PF02074
(Peptidase_M32) 		5 ASN A 268
GLU A 313
ARG A 310
ASP A 416
GLN A 415
 None
 1.15A 4uroC-3hoaA:
undetectable		 4uroC-3hoaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		5 ILE A 396
PRO A 395
ALA A 394
ILE A 376
ARG A 397
 None
 1.33A 4uroC-3hvyA:
undetectable		 4uroC-3hvyA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		5 ILE A 396
PRO A 395
ALA A 394
ILE A 376
ARG A 397
 None
 1.23A 4uroC-3i16A:
undetectable		 4uroC-3i16A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
horikoshii) 		PF07969
(Amidohydro_3) 		5 ARG X 310
ILE X 329
ASP X 282
ALA X 331
ILE X 353
 None
 1.33A 4uroC-3ighX:
undetectable		 4uroC-3ighX:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 ARG A 190
ILE A 213
ILE A 243
SER A 257
ARG A 212
 None
 1.19A 4uroC-3jskA:
undetectable		 4uroC-3jskA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lps TOPOISOMERASE IV
SUBUNIT B

(Xanthomonas
oryzae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		8 ASN A  86
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ASP A 121
ILE A 134
ARG A 176
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
 0.53A 4uroC-3lpsA:
28.0		 4uroC-3lpsA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN

(Pyrococcus
horikoshii) 		PF04016
(DUF364)
PF13938
(DUF4213) 		5 ILE A   9
ASP A  74
ALA A  73
ILE A  88
SER A  92
 None
 1.15A 4uroC-3npgA:
undetectable		 4uroC-3npgA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbk FATTY ACYL-ADENYLATE
LIGASE

(Escherichia
coli) 		PF00501
(AMP-binding) 		5 GLU A 366
ARG A 362
ILE A 464
ALA A 493
ILE A 501
 None
 1.08A 4uroC-3pbkA:
undetectable		 4uroC-3pbkA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm2 PHOSPHOSERINE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00266
(Aminotran_5) 		5 ASN A 299
ARG A 129
ASP A  98
ALA A 103
SER A 177
 None
 1.08A 4uroC-3qm2A:
undetectable		 4uroC-3qm2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		5 GLU A 247
ILE A 251
PRO A 250
ASP A 145
ILE A 226
 FMT  A 375 ( 4.8A)
None
None
None
None
 1.28A 4uroC-3rpwA:
undetectable		 4uroC-3rpwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens) 		PF00536
(SAM_1)
PF07647
(SAM_2) 		5 ARG B1112
ILE B1114
ALA B1126
ILE B1129
SER B1132
 None
 1.30A 4uroC-3tacB:
undetectable		 4uroC-3tacB:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u2k DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		10 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
ALA A  98
ILE A 102
ARG A 144
 087  A   1 (-3.9A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-3.8A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
None
087  A   1 (-2.5A)
 0.31A 4uroC-3u2kA:
32.0		 4uroC-3u2kA:
84.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3u2k DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		8 ASN A  54
GLU A  58
ASP A  81
ILE A  86
PRO A  87
GLN A  91
ALA A  98
ILE A 102
 087  A   1 (-3.9A)
087  A   1 (-3.4A)
087  A   1 (-3.5A)
087  A   1 (-4.4A)
087  A   1 (-4.3A)
None
None
None
 0.98A 4uroC-3u2kA:
32.0		 4uroC-3u2kA:
84.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		5 GLU A  23
ARG A  55
ILE A  21
ALA A  51
ILE A  40
 None
 0.93A 4uroC-3vseA:
undetectable		 4uroC-3vseA:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		6 ASN A  52
GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
None
ANP  A 601 (-4.3A)
None
 0.69A 4uroC-3zkbA:
28.8		 4uroC-3zkbA:
39.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		6 ASN A  52
GLU A  56
ASP A  79
ILE A  84
PRO A  85
ARG A 141
 ANP  A 601 ( 2.6A)
ANP  A 601 (-3.9A)
ANP  A 601 (-3.7A)
ANP  A 601 (-4.3A)
None
None
 0.66A 4uroC-3zkbA:
28.8		 4uroC-3zkbA:
39.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLU A1058
ILE A 580
PRO A 579
ILE A1191
SER A1261
 None
 1.19A 4uroC-3zyvA:
undetectable		 4uroC-3zyvA:
11.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b6c DNA GYRASE SUBUNIT B

(Mycolicibacterium
smegmatis) 		PF02518
(HATPase_c) 		6 ASN A  52
GLU A  56
ASP A  79
ILE A  84
PRO A  85
ARG A 141
 B5U  A1256 (-3.2A)
B5U  A1256 (-3.6A)
B5U  A1256 (-3.5A)
B5U  A1256 (-4.3A)
B5U  A1256 (-4.2A)
B5U  A1256 ( 4.4A)
 0.59A 4uroC-4b6cA:
24.8		 4uroC-4b6cA:
48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b6c DNA GYRASE SUBUNIT B

(Mycolicibacterium
smegmatis) 		PF02518
(HATPase_c) 		6 GLU A  56
ASP A  79
ARG A  82
ILE A  84
PRO A  85
ARG A 141
 B5U  A1256 (-3.6A)
B5U  A1256 (-3.5A)
B5U  A1256 (-3.4A)
B5U  A1256 (-4.3A)
B5U  A1256 (-4.2A)
B5U  A1256 ( 4.4A)
 0.40A 4uroC-4b6cA:
24.8		 4uroC-4b6cA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE,
IRON-SULFUR PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD) 		5 GLU B  52
ARG B 293
ILE B 246
ALA B 212
ILE B 210
 None
 0.92A 4uroC-4c1nB:
undetectable		 4uroC-4c1nB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
0H7  A 502 (-3.1A)
0H7  A 502 (-3.1A)
None
 1.06A 4uroC-4da5A:
undetectable		 4uroC-4da5A:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		7 ASN A  51
GLU A  55
ASP A  78
ARG A  81
ILE A  98
SER A 124
ARG A 140
 0RA  A 301 (-4.7A)
0RA  A 301 (-3.4A)
0RA  A 301 (-3.6A)
0RA  A 301 ( 3.8A)
None
None
0RA  A 301 (-2.5A)
 0.74A 4uroC-4em7A:
29.5		 4uroC-4em7A:
53.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4em7 DNA TOPOISOMERASE
IV, B SUBUNIT

(Streptococcus
pneumoniae) 		PF02518
(HATPase_c) 		6 ASN A  51
GLU A  55
ASP A  78
ARG A  81
PRO A  84
ILE A  98
 0RA  A 301 (-4.7A)
0RA  A 301 (-3.4A)
0RA  A 301 (-3.6A)
0RA  A 301 ( 3.8A)
0RA  A 301 ( 4.8A)
None
 0.73A 4uroC-4em7A:
29.5		 4uroC-4em7A:
53.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		5 ASN A 216
ASP A 194
PRO A 257
ALA A 260
ILE A 261
 None
 1.05A 4uroC-4fhaA:
undetectable		 4uroC-4fhaA:
20.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hxw DNA GYRASE SUBUNIT B

(Enterococcus
faecalis) 		PF02518
(HATPase_c) 		9 ASN A  55
GLU A  59
ASP A  82
ARG A  85
ILE A  87
PRO A  88
GLN A  92
ALA A  99
SER A 129
 1A0  A 301 (-3.8A)
1A0  A 301 (-3.2A)
1A0  A 301 (-3.4A)
1A0  A 301 (-3.5A)
1A0  A 301 (-3.9A)
1A0  A 301 (-4.2A)
None
None
1A0  A 301 (-3.2A)
 0.91A 4uroC-4hxwA:
32.3		 4uroC-4hxwA:
65.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		6 ASN A  41
GLU A  45
ASP A  68
ARG A  71
ILE A  89
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 (-4.6A)
CJC  A 401 (-4.2A)
 0.52A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		6 ASN A  41
GLU A  45
ASP A  68
ARG A  71
PRO A  74
ARG A 131
 CJC  A 401 (-4.0A)
CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
CJC  A 401 (-4.2A)
 0.79A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hym TOPOISOMERASE IV,
SUBUNIT B

(Francisella
tularensis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		6 GLU A  45
ASP A  68
ARG A  71
PRO A  74
ASP A  76
ARG A 131
 CJC  A 401 (-3.3A)
CJC  A 401 (-3.3A)
CJC  A 401 ( 4.0A)
CJC  A 401 ( 4.7A)
None
CJC  A 401 (-4.2A)
 1.20A 4uroC-4hymA:
27.8		 4uroC-4hymA:
27.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hz5 DNA TOPOISOMERASE
IV, B SUBUNIT

(Enterococcus
faecalis) 		PF02518
(HATPase_c) 		7 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
 19Y  A 301 (-3.8A)
19Y  A 301 (-3.3A)
19Y  A 301 (-3.3A)
19Y  A 301 (-4.0A)
19Y  A 301 (-4.0A)
19Y  A 301 ( 4.7A)
19Y  A 301 ( 4.8A)
 0.48A 4uroC-4hz5A:
30.3		 4uroC-4hz5A:
54.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jas HISTIDINE KINASE

(Thermotoga
maritima) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		6 ASN A 380
ASP A 411
ILE A 416
PRO A 417
ALA A 420
ILE A 424
 ADP  A 501 ( 2.7A)
ADP  A 501 (-3.4A)
ADP  A 501 (-4.6A)
None
None
ADP  A 501 (-3.7A)
 1.07A 4uroC-4jasA:
5.0		 4uroC-4jasA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3b OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA

(Neisseria
gonorrhoeae) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA) 		5 ASN A  97
ILE A 166
PRO A 152
GLN A 126
ILE A 164
 None
 1.33A 4uroC-4k3bA:
undetectable		 4uroC-4k3bA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc8 GLYCOSIDE HYDROLASE,
FAMILY 43

(Thermotoga
petrophila) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		5 ASN A  71
ASP A  69
ALA A 113
ILE A  94
ARG A  91
 None
 1.19A 4uroC-4kc8A:
undetectable		 4uroC-4kc8A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe3 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		5 GLU A 262
ILE A 102
PRO A  99
ALA A 101
ILE A 107
 ACT  A 404 (-2.8A)
None
ACT  A 404 (-4.0A)
None
None
 1.28A 4uroC-4pe3A:
undetectable		 4uroC-4pe3A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9o ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		5 ARG A 193
ILE A 179
GLN A 155
ALA A 156
ILE A 160
 None
 1.19A 4uroC-4q9oA:
undetectable		 4uroC-4q9oA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum) 		PF00719
(Pyrophosphatase) 		5 GLU A  60
ILE A  57
ASP A 118
ALA A  93
SER A  25
 None
None
CO  A 401 (-2.5A)
None
None
 1.27A 4uroC-4qlzA:
undetectable		 4uroC-4qlzA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r39 BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13581
(HATPase_c_2) 		5 ASP A 282
ARG A 285
ILE A 287
PRO A 288
ASP A 290
 ANP  A 402 (-2.7A)
None
ANP  A 402 (-4.3A)
ANP  A 402 ( 4.4A)
None
 1.29A 4uroC-4r39A:
4.1		 4uroC-4r39A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 ARG A 265
ILE A 264
ALA A 259
ILE A 199
SER A 202
 None
 1.19A 4uroC-4rewA:
undetectable		 4uroC-4rewA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8t ZYRO0G01672P

(Zygosaccharomyces
rouxii) 		PF04146
(YTH) 		5 ASN A 207
GLU A 212
GLN A 299
SER A 202
ARG A 179
 None
 1.33A 4uroC-4u8tA:
undetectable		 4uroC-4u8tA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4url DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 ASN A  49
GLU A  53
ASP A  76
ARG A  79
ARG A 138
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
None
 0.72A 4uroC-4urlA:
30.0		 4uroC-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4url DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		6 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
 XAM  A2000 (-3.9A)
XAM  A2000 (-3.1A)
XAM  A2000 (-3.6A)
XAM  A2000 (-3.7A)
XAM  A2000 (-4.8A)
None
 0.58A 4uroC-4urlA:
30.0		 4uroC-4urlA:
37.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4urm DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		8 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
ASP A  89
SER A 128
 XAM  A2000 (-3.7A)
XAM  A2000 (-2.6A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.6A)
XAM  A2000 (-4.5A)
XAM  A2000 ( 4.9A)
None
XAM  A2000 ( 4.4A)
 0.96A 4uroC-4urmA:
32.9		 4uroC-4urmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4urm DNA GYRASE SUBUNIT B

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		11 ASN A  54
GLU A  58
ASP A  81
ARG A  84
ILE A  86
PRO A  87
GLN A  91
ALA A  98
ILE A 102
SER A 128
ARG A 144
 XAM  A2000 (-3.7A)
XAM  A2000 (-2.6A)
XAM  A2000 (-3.4A)
XAM  A2000 (-3.6A)
XAM  A2000 (-4.5A)
XAM  A2000 ( 4.9A)
XAM  A2000 (-3.2A)
XAM  A2000 ( 3.8A)
XAM  A2000 (-4.5A)
XAM  A2000 ( 4.4A)
None
 0.71A 4uroC-4urmA:
32.9		 4uroC-4urmA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4urn DNA TOPOISOMERASE
IV, B SUBUNIT

(Staphylococcus
aureus) 		PF02518
(HATPase_c) 		7 ASN A  49
GLU A  53
ASP A  76
ARG A  79
PRO A  82
ILE A  96
ARG A 138
 NOV  A2000 (-3.8A)
NOV  A2000 (-3.4A)
NOV  A2000 (-3.5A)
NOV  A2000 (-3.2A)
NOV  A2000 (-4.1A)
NOV  A2000 (-4.2A)
NOV  A2000 (-2.9A)
 0.65A 4uroC-4urnA:
30.5		 4uroC-4urnA:
58.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0k ARF-LIKE SMALL
GTPASE

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		5 ILE A 157
ASP A 148
ALA A 142
ILE A 141
SER A  96
 None
 1.09A 4uroC-4v0kA:
undetectable		 4uroC-4v0kA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 5 ASP B 176
ILE B 133
ASP B  63
ALA B  68
ILE B  71
 None
 1.27A 4uroC-4w5uB:
undetectable		 4uroC-4w5uB:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		5 GLU A 125
ARG A 174
ILE A 151
ALA A 182
ILE A 149
 None
 1.24A 4uroC-4w87A:
undetectable		 4uroC-4w87A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yds FLAGELLA-RELATED
PROTEIN H

(Sulfolobus
acidocaldarius) 		PF06745
(ATPase) 		5 ASP A  11
ILE A  17
PRO A  18
ALA A  21
ILE A  23
 None
 1.21A 4uroC-4ydsA:
undetectable		 4uroC-4ydsA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zlg PUTATIVE B-GLYCAN
PHOSPHORYLASE

(Saccharophagus
degradans) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 GLU A 573
ILE A 576
GLN A 562
ILE A 566
SER A 637
 None
 1.16A 4uroC-4zlgA:
undetectable		 4uroC-4zlgA:
15.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4zvi DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		9 ASN A  46
GLU A  50
ASP A  73
ARG A  76
ILE A  78
PRO A  79
ALA A  90
ILE A  94
ARG A 136
 4S4  A 401 (-4.3A)
4S4  A 401 (-3.1A)
4S4  A 401 (-3.4A)
4S4  A 401 (-2.8A)
4S4  A 401 (-4.4A)
4S4  A 401 (-4.5A)
None
None
None
 0.48A 4uroC-4zviA:
30.8		 4uroC-4zviA:
57.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT DELTA

(Schizosaccharomyces
pombe) 		PF01008
(IF-2B) 		5 ILE G 137
PRO G 138
ASP G 140
GLN G 197
ILE G 146
 None
 1.33A 4uroC-5b04G:
undetectable		 4uroC-5b04G:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cq9 SECRETED EFFECTOR
PROTEIN SOPD2

(Salmonella
enterica) 		PF11047
(SopD) 		5 ASN A 204
GLU A 310
ILE A 308
ILE A 298
SER A 301
 None
 1.16A 4uroC-5cq9A:
undetectable		 4uroC-5cq9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eow 6-HYDROXYNICOTINATE
3-MONOOXYGENASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLU A  62
ARG A  57
ALA A 315
ILE A 311
ARG A  58
 None
 1.17A 4uroC-5eowA:
undetectable		 4uroC-5eowA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftg CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		5 GLU A 206
ILE A 329
ASP A 306
GLN A 308
SER A 211
 None
None
EDO  A1466 ( 3.0A)
NBR  A1458 ( 3.3A)
None
 0.91A 4uroC-5ftgA:
undetectable		 4uroC-5ftgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyl LEGUMIN-LIKE PROTEIN

(Cicer arietinum) 		PF00190
(Cupin_1) 		5 ASN A 376
PRO A 373
GLN A 393
ALA A 422
ILE A 421
 None
 1.26A 4uroC-5gylA:
undetectable		 4uroC-5gylA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5l GLUTATHIONE
S-TRANSFERASE S2

(Nilaparvata
lugens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 ASP A  31
ILE A  18
PRO A  17
ALA A  68
ILE A  67
 None
 1.16A 4uroC-5h5lA:
undetectable		 4uroC-5h5lA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		5 GLU A 288
ASP A 286
ILE A 356
GLN A 309
ILE A 294
 None
 1.34A 4uroC-5hy4A:
undetectable		 4uroC-5hy4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5l BACTERIOPHYTOCHROME
PROTEIN

(Agrobacterium
fabrum) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 ILE A 224
PRO A 223
ILE A  31
SER A 241
ARG A 225
 None
 1.13A 4uroC-5i5lA:
undetectable		 4uroC-5i5lA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idm CELL CYCLE HISTIDINE
KINASE CCKA

(Caulobacter
vibrioides) 		PF02518
(HATPase_c) 		6 ASN A 434
ASP A 479
ILE A 484
PRO A 485
ASP A 487
ILE A 492
 MG  A 602 ( 2.6A)
ANP  A 601 (-3.5A)
ANP  A 601 (-4.5A)
None
None
ANP  A 601 ( 4.0A)
 1.04A 4uroC-5idmA:
6.2		 4uroC-5idmA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3

(Homo sapiens) 		PF03850
(Tfb4) 		5 ASP 3 169
ILE 3 181
GLN 3 187
ALA 3 184
ILE 3 191
 None
 1.14A 4uroC-5ivw3:
undetectable		 4uroC-5ivw3:
22.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j5p DNA TOPOISOMERASE 4
SUBUNIT B

(Streptococcus
pneumoniae) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		8 ASN A  51
GLU A  55
ASP A  78
ARG A  81
PRO A  84
ILE A  98
SER A 124
ARG A 140
 MG  A 503 ( 2.5A)
ANP  A 501 (-3.2A)
ANP  A 501 (-2.6A)
None
None
ANP  A 501 ( 3.4A)
ANP  A 501 (-3.2A)
None
 0.78A 4uroC-5j5pA:
28.8		 4uroC-5j5pA:
40.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		5 ILE A 549
PRO A 548
ALA A 552
ILE A 380
SER A 286
 None
 1.14A 4uroC-5jwfA:
undetectable		 4uroC-5jwfA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kel C2G4 VARIABLE FAB
DOMAIN HEAVY CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 ASP H  73
ARG H  94
ILE H  51
ALA H  49
ILE H  69
 None
 1.23A 4uroC-5kelH:
undetectable		 4uroC-5kelH:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh5 ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		5 ARG A 193
ILE A 179
GLN A 155
ALA A 156
ILE A 160
 None
 1.07A 4uroC-5kh5A:
undetectable		 4uroC-5kh5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		5 ILE B   9
PRO A 103
ASP A 100
ALA A  98
SER B  23
 None
 1.29A 4uroC-5tjfB:
undetectable		 4uroC-5tjfB:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 5 GLU D 914
ASP D 912
ARG D 956
GLN D 887
ALA D 883
 None
 1.29A 4uroC-5xbkD:
undetectable		 4uroC-5xbkD:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 5 ARG A  67
ILE A  81
ASP A  74
ALA A  77
ILE A  62
 None
 1.27A 4uroC-6c8zA:
undetectable		 4uroC-6c8zA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6coy CHLORIDE CHANNEL
PROTEIN 1

(Homo sapiens) 		no annotation 5 ILE A 479
PRO A 478
ALA A 176
ILE A 172
SER A 225
 None
 1.08A 4uroC-6coyA:
undetectable		 4uroC-6coyA:
12.88