SIMILAR PATTERNS OF AMINO ACIDS FOR 4UMJ_B_BFQB1294_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		5 SER A  88
LEU A  92
ASP A  91
ASP A 325
GLN A  87
 None
 1.41A 4umjB-1dnvA:
undetectable		 4umjB-1dnvA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ASP A 117
ARG A 126
GLN A 185
THR A 215
 None
 0.75A 4umjB-1fpsA:
23.1		 4umjB-1fpsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		5 LEU A 114
ASP A 117
ASP A 121
ARG A 126
THR A 215
 None
 0.60A 4umjB-1fpsA:
23.1		 4umjB-1fpsA:
27.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		7 SER A 101
LEU A 102
ASP A 105
ARG A 116
MET A 175
LYS A 202
THR A 203
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 4.5A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
 0.68A 4umjB-1rqjA:
35.8		 4umjB-1rqjA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		8 SER A 101
LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
THR A 203
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
IPE  A 900 ( 3.3A)
 0.53A 4umjB-1rqjA:
35.8		 4umjB-1rqjA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  82
ARG A  93
GLN A 154
THR A 178
 None
 0.98A 4umjB-1rtrA:
36.9		 4umjB-1rtrA:
37.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		7 SER A  78
LEU A  79
ASP A  88
ARG A  93
MET A 150
GLN A 154
THR A 178
 None
 0.42A 4umjB-1rtrA:
36.9		 4umjB-1rtrA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 SER A  77
LEU A  78
ASP A  81
ARG A  90
LYS A 166
 None
 0.97A 4umjB-1wl1A:
22.0		 4umjB-1wl1A:
23.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
 None
 1.23A 4umjB-1wmwA:
26.2		 4umjB-1wmwA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		6 SER A  82
LEU A  83
ARG A  95
GLN A 153
LYS A 177
THR A 178
 None
 0.80A 4umjB-1wy0A:
33.6		 4umjB-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		6 SER A  82
LEU A  83
ASP A  86
GLN A 153
LYS A 177
THR A 178
 None
 1.21A 4umjB-1wy0A:
33.6		 4umjB-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		6 SER A  82
LEU A  83
ASP A  90
ARG A  95
GLN A 153
THR A 178
 None
 0.53A 4umjB-1wy0A:
33.6		 4umjB-1wy0A:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 SER A  77
LEU A  78
ASP A  81
ARG A  90
THR A 161
 None
 1.03A 4umjB-2azkA:
27.7		 4umjB-2azkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		5 SER A  77
LEU A  78
ASP A  85
ARG A  90
THR A 161
 None
 0.79A 4umjB-2azkA:
27.7		 4umjB-2azkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		7 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 0.49A 4umjB-2dh4A:
20.3		 4umjB-2dh4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		7 SER A  76
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
THR A 175
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 0.73A 4umjB-2dh4A:
20.3		 4umjB-2dh4A:
23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 SER A  70
LEU A  71
ASP A  74
ARG A  85
THR A 164
 UNL  A 273 (-3.7A)
None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
 0.80A 4umjB-2ftzA:
29.2		 4umjB-2ftzA:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 SER A  70
LEU A  71
ASP A  80
ARG A  85
THR A 164
 UNL  A 273 (-3.7A)
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.9A)
 0.27A 4umjB-2ftzA:
29.2		 4umjB-2ftzA:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 SER A 121
LEU A 122
ARG A 136
GLN A 198
THR A 222
 None
 1.02A 4umjB-2h8oA:
37.7		 4umjB-2h8oA:
41.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 SER A 121
LEU A 122
ASP A 125
GLN A 198
THR A 222
 None
 1.19A 4umjB-2h8oA:
37.7		 4umjB-2h8oA:
41.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		6 SER A 121
LEU A 122
ASP A 131
ARG A 136
MET A 194
THR A 222
 None
 0.65A 4umjB-2h8oA:
37.7		 4umjB-2h8oA:
41.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		7 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
THR A 211
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.7A)
 0.58A 4umjB-2o1oA:
22.5		 4umjB-2o1oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		5 LEU A 112
ASP A 115
ASP A 119
ARG A 124
THR A 180
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
None
 1.19A 4umjB-2o1oA:
22.5		 4umjB-2o1oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		8 SER A  60
LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
THR A 152
 GRG  A 500 ( 4.2A)
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 ( 4.6A)
 0.65A 4umjB-2q80A:
20.6		 4umjB-2q80A:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		7 SER A 103
LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
THR A 194
 FPP  A1002 (-4.2A)
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
ISY  A1003 (-4.7A)
 0.61A 4umjB-3aq0A:
29.1		 4umjB-3aq0A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		7 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
THR B 171
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 0.82A 4umjB-3aqcB:
28.8		 4umjB-3aqcB:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE

(Methanosarcina
mazei) 		PF00348
(polyprenyl_synt) 		5 SER A  86
LEU A  87
ASP A  90
MET A 147
THR A 175
 None
 1.10A 4umjB-3ipiA:
27.3		 4umjB-3ipiA:
29.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		5 SER A  79
LEU A  80
ASP A  83
ASP A  89
THR A 181
 None
None
None
None
IPE  A 902 ( 3.7A)
 0.84A 4umjB-3krcA:
39.3		 4umjB-3krcA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		5 SER A  79
LEU A  80
ASP A  89
ARG A  94
THR A 181
 None
None
None
None
IPE  A 902 ( 3.7A)
 0.73A 4umjB-3krcA:
39.3		 4umjB-3krcA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		5 LEU A  91
ASP A  94
ASP A 100
GLN A 168
THR A 193
 None
 1.24A 4umjB-3lomA:
33.5		 4umjB-3lomA:
38.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		7 SER A  90
LEU A  91
ASP A 100
ARG A 105
MET A 164
GLN A 168
THR A 193
 None
 0.68A 4umjB-3lomA:
33.5		 4umjB-3lomA:
38.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		6 LEU A  78
ASP A  81
ASP A  87
GLN A 153
LYS A 178
THR A 179
 None
 1.16A 4umjB-3m0gA:
36.7		 4umjB-3m0gA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		8 SER A  77
LEU A  78
ASP A  87
ARG A  92
MET A 149
GLN A 153
LYS A 178
THR A 179
 None
 0.62A 4umjB-3m0gA:
36.7		 4umjB-3m0gA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		6 SER A  85
LEU A  86
ASP A  89
ARG A 100
GLN A 160
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
None
 1.12A 4umjB-3m9uA:
34.9		 4umjB-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		6 SER A  85
LEU A  86
ASP A  89
ASP A  95
ARG A 100
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
None
 0.71A 4umjB-3m9uA:
34.9		 4umjB-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		6 SER A  85
LEU A  86
ASP A  89
ASP A  95
LYS A 183
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
None
 0.93A 4umjB-3m9uA:
34.9		 4umjB-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		6 SER A  85
LEU A  86
ASP A  89
GLN A 160
LYS A 183
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
None
 1.29A 4umjB-3m9uA:
34.9		 4umjB-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		6 SER A  85
LEU A  86
ASP A  95
ARG A 100
MET A 156
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
None
 0.42A 4umjB-3m9uA:
34.9		 4umjB-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		6 SER A  85
LEU A  86
ASP A  95
MET A 156
LYS A 183
THR A 184
 None
GOL  A 310 ( 4.3A)
None
None
None
None
 0.71A 4umjB-3m9uA:
34.9		 4umjB-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A  90
ASP A  93
ARG A 102
LYS A 179
THR A 180
 None
 0.74A 4umjB-3mzvA:
29.2		 4umjB-3mzvA:
33.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		5 SER A 124
LEU A 125
ASP A 132
ARG A 137
GLN A 193
 None
None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
 0.90A 4umjB-3nf2A:
30.3		 4umjB-3nf2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		5 SER A 124
LEU A 125
ASP A 132
ARG A 137
LYS A 217
 None
None
SO4  A   3 (-4.2A)
None
SO4  A   3 (-2.8A)
 0.96A 4umjB-3nf2A:
30.3		 4umjB-3nf2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		5 SER A 124
LEU A 125
ASP A 132
ARG A 137
THR A 218
 None
None
SO4  A   3 (-4.2A)
None
None
 1.01A 4umjB-3nf2A:
30.3		 4umjB-3nf2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		6 LEU A  75
ASP A  78
ARG A  89
GLN A 149
LYS A 172
THR A 173
 None
 1.10A 4umjB-3npkA:
32.8		 4umjB-3npkA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		8 SER A  74
LEU A  75
ASP A  84
ARG A  89
MET A 145
GLN A 149
LYS A 172
THR A 173
 None
 0.56A 4umjB-3npkA:
32.8		 4umjB-3npkA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		9 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
MET A 153
GLN A 157
LYS A 180
THR A 181
 DMA  A 300 (-3.7A)
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 ( 4.3A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
None
 0.40A 4umjB-3p41A:
43.8		 4umjB-3p41A:
76.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		6 LEU A  79
ASP A  82
ASP A  88
ARG A  93
GLN A 153
THR A 177
 None
 0.97A 4umjB-3p8lA:
35.9		 4umjB-3p8lA:
44.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		7 SER A  78
LEU A  79
ASP A  88
ARG A  93
MET A 149
GLN A 153
THR A 177
 None
 0.44A 4umjB-3p8lA:
35.9		 4umjB-3p8lA:
44.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		6 SER A  78
LEU A  79
ASP A  82
MET A 152
GLN A 156
THR A 180
 None
 0.83A 4umjB-3p8rA:
34.8		 4umjB-3p8rA:
52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		5 SER A  78
LEU A  79
MET A 152
LYS A 179
THR A 180
 None
 0.90A 4umjB-3p8rA:
34.8		 4umjB-3p8rA:
52.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  84
ASP A  87
ARG A  96
LYS A 174
THR A 175
 None
None
CIT  A 326 ( 4.8A)
None
None
 0.89A 4umjB-3pkoA:
26.7		 4umjB-3pkoA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 LEU A  84
ASP A  91
ARG A  96
LYS A 174
THR A 175
 None
None
CIT  A 326 ( 4.8A)
None
None
 0.65A 4umjB-3pkoA:
26.7		 4umjB-3pkoA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		8 SER A  88
LEU A  89
ASP A  92
ASP A  98
ARG A 103
GLN A 163
LYS A 186
THR A 187
 DMA  A 501 (-3.4A)
DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
 0.51A 4umjB-3q1oA:
29.7		 4umjB-3q1oA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		8 SER A  88
LEU A  89
ASP A  92
ASP A  98
ARG A 103
MET A 159
LYS A 186
THR A 187
 DMA  A 501 (-3.4A)
DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 ( 3.8A)
DMA  A 501 (-3.1A)
DMA  A 500 (-3.4A)
 0.71A 4umjB-3q1oA:
29.7		 4umjB-3q1oA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 191
THR A 216
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 383 ( 4.0A)
 0.84A 4umjB-3qqvA:
27.7		 4umjB-3qqvA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		6 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
THR A 216
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 ( 4.0A)
 0.50A 4umjB-3qqvA:
27.7		 4umjB-3qqvA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 SER A  73
LEU A  74
ASP A  77
LYS A 162
THR A 163
 None
 0.79A 4umjB-3tc1A:
22.9		 4umjB-3tc1A:
24.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		7 LEU A  85
ASP A  88
ASP A  94
ARG A  99
GLN A 162
LYS A 185
THR A 186
 None
 1.09A 4umjB-3ts7A:
38.3		 4umjB-3ts7A:
57.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		8 SER A  84
LEU A  85
ASP A  94
ARG A  99
MET A 158
GLN A 162
LYS A 185
THR A 186
 None
 0.70A 4umjB-3ts7A:
38.3		 4umjB-3ts7A:
57.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		5 SER A  87
LEU A  88
ASP A  91
GLN A 163
THR A 188
 None
 1.10A 4umjB-3ucaA:
35.1		 4umjB-3ucaA:
38.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		7 SER A  87
LEU A  88
ASP A  97
ARG A 102
MET A 159
GLN A 163
THR A 188
 None
 0.53A 4umjB-3ucaA:
35.1		 4umjB-3ucaA:
38.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 1.00A 4umjB-3wjoA:
29.4		 4umjB-3wjoA:
29.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ASP A  84
ASP A  88
ARG A  93
THR A 171
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 402 ( 3.8A)
 0.38A 4umjB-3wjoA:
29.4		 4umjB-3wjoA:
29.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		9 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
MET A 153
GLN A 157
LYS A 180
THR A 181
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 ( 4.6A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
None
 0.34A 4umjB-3zouA:
46.7		 4umjB-3zouA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
IPE  A 405 ( 4.6A)
 0.45A 4umjB-4e1eA:
23.5		 4umjB-4e1eA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		5 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
None
 1.18A 4umjB-4e1eA:
23.5		 4umjB-4e1eA:
25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		7 SER A  79
LEU A  80
ASP A  83
ASP A  89
MET A 151
LYS A 178
THR A 179
 None
 0.53A 4umjB-4f62A:
37.4		 4umjB-4f62A:
50.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		6 SER A  79
LEU A  80
ASP A  83
GLN A 155
LYS A 178
THR A 179
 None
 1.02A 4umjB-4f62A:
37.4		 4umjB-4f62A:
50.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  90
ARG A  95
GLN A 147
THR A 163
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.90A 4umjB-4fp4A:
24.6		 4umjB-4fp4A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		7 SER A  82
LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
THR A 163
 GER  A 301 (-4.5A)
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
None
 0.94A 4umjB-4fp4A:
24.6		 4umjB-4fp4A:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
THR A 185
 None
 0.69A 4umjB-4gp1A:
29.0		 4umjB-4gp1A:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 SER A  81
LEU A  82
ASP A  85
ASP A  89
ARG A  94
THR A 185
 None
 0.75A 4umjB-4gp1A:
29.0		 4umjB-4gp1A:
33.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		7 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
THR A 208
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 ( 3.4A)
 0.53A 4umjB-4jzxA:
24.2		 4umjB-4jzxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		5 LEU A  95
ASP A  98
ASP A 102
ARG A 107
THR A 163
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-4.8A)
 1.14A 4umjB-4jzxA:
24.2		 4umjB-4jzxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		6 LEU A  94
ASP A  97
ARG A 106
GLN A 165
LYS A 194
THR A 195
 None
 0.72A 4umjB-4kk2A:
23.1		 4umjB-4kk2A:
25.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  92
ARG A  97
LYS A 184
THR A 185
 None
 0.88A 4umjB-4kkmA:
38.1		 4umjB-4kkmA:
46.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		7 SER A  82
LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
THR A 185
 None
 0.58A 4umjB-4kkmA:
38.1		 4umjB-4kkmA:
46.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		7 SER A  82
LEU A  83
ASP A  86
ASP A  92
ARG A  97
MET A 155
THR A 185
 None
 0.70A 4umjB-4kkmA:
38.1		 4umjB-4kkmA:
46.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		8 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 0.54A 4umjB-4lfeA:
33.5		 4umjB-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		8 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
MET A 145
LYS A 172
THR A 173
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 4.2A)
IPE  A 301 (-3.0A)
None
 0.70A 4umjB-4lfeA:
33.5		 4umjB-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		9 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
MET A 149
GLN A 153
LYS A 178
THR A 179
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 ( 4.1A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
IPE  A 301 (-4.2A)
 0.45A 4umjB-4llsA:
35.4		 4umjB-4llsA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
THR A 201
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.7A)
 0.59A 4umjB-4p0vA:
23.8		 4umjB-4p0vA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 167
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
None
 1.24A 4umjB-4p0vA:
23.8		 4umjB-4p0vA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
THR A 213
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 (-4.2A)
 0.68A 4umjB-4rxeA:
23.6		 4umjB-4rxeA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		5 LEU A 100
ASP A 103
ASP A 107
ARG A 112
THR A 168
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
None
 1.16A 4umjB-4rxeA:
23.6		 4umjB-4rxeA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		7 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
THR B 213
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 (-4.2A)
 0.51A 4umjB-5ahuB:
9.4		 4umjB-5ahuB:
23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		8 SER A  82
LEU A  83
ASP A  86
ASP A  92
ARG A  97
MET A 156
GLN A 160
THR A 184
 None
 0.60A 4umjB-5aypA:
35.7		 4umjB-5aypA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		8 SER A  82
LEU A  83
ASP A  92
ARG A  97
MET A 156
GLN A 160
LYS A 183
THR A 184
 None
 0.78A 4umjB-5aypA:
35.7		 4umjB-5aypA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A  89
ASP A  92
ARG A 103
GLN A 166
THR A 193
 None
 1.20A 4umjB-5e8hA:
38.4		 4umjB-5e8hA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 SER A  88
LEU A  89
ASP A  98
ARG A 103
THR A 193
 None
 0.49A 4umjB-5e8hA:
38.4		 4umjB-5e8hA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 SER A  87
LEU A  88
ASP A  97
GLN A 163
THR A 191
 None
 1.03A 4umjB-5e8kA:
36.4		 4umjB-5e8kA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 ASP A  97
ARG A 102
GLN A 166
LYS A 192
THR A 193
 None
 1.18A 4umjB-5e8lA:
37.8		 4umjB-5e8lA:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		6 LEU A  88
ASP A  91
ASP A  97
ARG A 102
GLN A 166
THR A 193
 None
 0.99A 4umjB-5e8lA:
37.8		 4umjB-5e8lA:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		6 SER A  87
LEU A  88
ASP A  91
ASP A  97
ARG A 102
THR A 193
 None
 0.77A 4umjB-5e8lA:
37.8		 4umjB-5e8lA:
46.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ern FUSICOCCADIENE
SYNTHASE

(Diaporthe
amygdali) 		PF00348
(polyprenyl_synt) 		5 LEU A  85
ASP A  88
GLN A 150
LYS A 175
THR A 176
 None
 1.11A 4umjB-5ernA:
12.9		 4umjB-5ernA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  82
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.93A 4umjB-5h9dA:
28.0		 4umjB-5h9dA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		5 LEU A  79
ASP A  86
ARG A  91
LYS A 168
THR A 169
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
None
 0.71A 4umjB-5h9dA:
28.0		 4umjB-5h9dA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		6 ASP A 126
ASP A 130
ARG A 135
GLN A 195
LYS A 243
THR A 244
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
04M  A 401 ( 3.8A)
 0.68A 4umjB-5hn7A:
22.9		 4umjB-5hn7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 6 ASP A 147
ASP A 151
ARG A 156
GLN A 215
LYS A 244
THR A 245
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.6A)
 0.55A 4umjB-6b07A:
23.2		 4umjB-6b07A:
12.33