SIMILAR PATTERNS OF AMINO ACIDS FOR 4UMJ_A_BFQA1297

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 LEU A 114
ASP A 117
ARG A 126
GLN A 185
 None
 0.67A 4umjA-1fpsA:
23.2		 4umjA-1fpsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 LEU A 114
ASP A 117
ASP A 121
ARG A 126
 None
 0.63A 4umjA-1fpsA:
23.2		 4umjA-1fpsA:
27.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 LEU A 420
ASP A 421
ASP A 422
LYS A 245
 None
 1.06A 4umjA-1jeqA:
undetectable		 4umjA-1jeqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 SER A  37
LEU A  82
ASP A  81
ASP A  79
 None
 0.78A 4umjA-1jeqA:
undetectable		 4umjA-1jeqA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jih DNA POLYMERASE ETA

(Saccharomyces
cerevisiae) 		PF00817
(IMS)
PF11799
(IMS_C) 		4 SER A  22
LEU A  23
ASP A 234
ASP A 235
 None
 0.84A 4umjA-1jihA:
undetectable		 4umjA-1jihA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8v NEUROPEPTIDE F

(Moniezia
expansa) 		no annotation 4 SER A  10
LEU A  12
ASP A  11
ASP A  15
 None
 1.05A 4umjA-1k8vA:
undetectable		 4umjA-1k8vA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 4 SER A 324
LEU A 325
ASP A 357
ASP A  18
 None
 0.96A 4umjA-1nluA:
undetectable		 4umjA-1nluA:
22.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		7 SER A 101
LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
 0.66A 4umjA-1rqjA:
35.7		 4umjA-1rqjA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		7 SER A 101
LEU A 102
ASP A 105
ASP A 111
ARG A 116
MET A 175
LYS A 202
 RIS  A 901 ( 3.8A)
None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 ( 4.5A)
RIS  A 901 (-2.5A)
 0.73A 4umjA-1rqjA:
35.7		 4umjA-1rqjA:
52.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		6 SER A  78
LEU A  79
ASP A  88
ARG A  93
MET A 150
GLN A 154
 None
 0.59A 4umjA-1rtrA:
36.7		 4umjA-1rtrA:
37.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 SER A  77
LEU A  78
ASP A  81
ARG A  90
LYS A 166
 None
 0.93A 4umjA-1wl1A:
21.5		 4umjA-1wl1A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 SER A  77
LEU A  78
ASP A  85
ARG A  90
 None
 0.61A 4umjA-1wl1A:
21.5		 4umjA-1wl1A:
23.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
 None
 1.13A 4umjA-1wmwA:
26.1		 4umjA-1wmwA:
33.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 SER A  82
LEU A  83
ARG A  95
GLN A 153
LYS A 177
 None
 0.80A 4umjA-1wy0A:
33.4		 4umjA-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 SER A  82
LEU A  83
ASP A  86
GLN A 153
LYS A 177
 None
 1.27A 4umjA-1wy0A:
33.4		 4umjA-1wy0A:
34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 SER A  82
LEU A  83
ASP A  90
ARG A  95
GLN A 153
 None
 0.38A 4umjA-1wy0A:
33.4		 4umjA-1wy0A:
34.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yo6 PUTATIVE CARBONYL
REDUCTASE SNIFFER

(Caenorhabditis
elegans) 		PF00106
(adh_short) 		4 SER A 152
LEU A 154
ASP A 159
ARG A 173
 None
 1.05A 4umjA-1yo6A:
undetectable		 4umjA-1yo6A:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 SER A  77
LEU A  78
ASP A  81
ARG A  90
 None
 0.94A 4umjA-2azkA:
27.6		 4umjA-2azkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 SER A  77
LEU A  78
ASP A  85
ARG A  90
 None
 0.77A 4umjA-2azkA:
27.6		 4umjA-2azkA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		6 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.43A 4umjA-2dh4A:
19.8		 4umjA-2dh4A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		6 SER A  76
ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.74A 4umjA-2dh4A:
19.8		 4umjA-2dh4A:
23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 SER A  70
LEU A  71
ASP A  74
ARG A  85
 UNL  A 273 (-3.7A)
None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
 0.85A 4umjA-2ftzA:
29.0		 4umjA-2ftzA:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 SER A  70
LEU A  71
ASP A  80
ARG A  85
 UNL  A 273 (-3.7A)
None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
 0.26A 4umjA-2ftzA:
29.0		 4umjA-2ftzA:
31.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		5 SER A 121
LEU A 122
ASP A 131
ARG A 136
MET A 194
 None
 0.65A 4umjA-2h8oA:
37.0		 4umjA-2h8oA:
41.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		6 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
 0.70A 4umjA-2o1oA:
22.4		 4umjA-2o1oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		7 SER A  60
LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
 GRG  A 500 ( 4.2A)
None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
 0.73A 4umjA-2q80A:
20.4		 4umjA-2q80A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wmo DEDICATOR OF
CYTOKINESIS PROTEIN
9

(Homo sapiens) 		PF06920
(DHR-2) 		4 LEU A 335
MET A 408
GLN A 405
LYS A 409
 None
 1.04A 4umjA-2wmoA:
3.5		 4umjA-2wmoA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		6 SER A 103
LEU A 104
ASP A 107
ASP A 111
ARG A 116
LYS A 193
 FPP  A1002 (-4.2A)
None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.65A 4umjA-3aq0A:
28.9		 4umjA-3aq0A:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		6 SER B  80
LEU B  81
ASP B  84
ASP B  88
ARG B  93
LYS B 170
 2DE  B 329 (-3.6A)
None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 0.94A 4umjA-3aqcB:
28.4		 4umjA-3aqcB:
32.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8w RIBONUCLEASE H

(Escherichia
virus T4) 		PF02739
(5_3_exonuc_N)
PF09293
(RNaseH_C) 		4 LEU A 255
ASP A 259
ASP A 261
GLN A 160
 None
 0.96A 4umjA-3h8wA:
undetectable		 4umjA-3h8wA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		5 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
 None
 0.82A 4umjA-3krcA:
39.3		 4umjA-3krcA:
48.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		6 SER A  90
LEU A  91
ASP A 100
ARG A 105
MET A 164
GLN A 168
 None
 0.62A 4umjA-3lomA:
33.2		 4umjA-3lomA:
38.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		7 SER A  77
LEU A  78
ASP A  87
ARG A  92
MET A 149
GLN A 153
LYS A 178
 None
 0.53A 4umjA-3m0gA:
36.3		 4umjA-3m0gA:
43.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
ASP A  89
ARG A 100
GLN A 160
 None
GOL  A 310 ( 4.3A)
None
None
None
 1.20A 4umjA-3m9uA:
33.8		 4umjA-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
ASP A  89
GLN A 160
LYS A 183
 None
GOL  A 310 ( 4.3A)
None
None
None
 1.47A 4umjA-3m9uA:
33.8		 4umjA-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
ASP A  95
ARG A 100
MET A 156
 None
GOL  A 310 ( 4.3A)
None
None
None
 0.40A 4umjA-3m9uA:
33.8		 4umjA-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 SER A  85
LEU A  86
ASP A  95
MET A 156
LYS A 183
 None
GOL  A 310 ( 4.3A)
None
None
None
 0.80A 4umjA-3m9uA:
33.8		 4umjA-3m9uA:
44.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 LEU A  90
ASP A  93
ARG A 102
LYS A 179
 None
 0.86A 4umjA-3mzvA:
29.0		 4umjA-3mzvA:
33.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		6 SER A 124
LEU A 125
ASP A 132
ARG A 137
GLN A 193
LYS A 217
 None
None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
SO4  A   3 (-2.8A)
 1.01A 4umjA-3nf2A:
29.7		 4umjA-3nf2A:
32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		6 SER A  74
LEU A  75
ASP A  84
ARG A  89
MET A 145
GLN A 149
 None
 0.35A 4umjA-3npkA:
32.5		 4umjA-3npkA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		6 SER A  74
LEU A  75
ASP A  84
MET A 145
GLN A 149
LYS A 172
 None
 0.56A 4umjA-3npkA:
32.5		 4umjA-3npkA:
34.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		8 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
MET A 153
GLN A 157
LYS A 180
 DMA  A 300 (-3.7A)
None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 ( 4.3A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 0.63A 4umjA-3p41A:
43.4		 4umjA-3p41A:
76.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		6 SER A  78
LEU A  79
ASP A  88
ARG A  93
MET A 149
GLN A 153
 None
 0.33A 4umjA-3p8lA:
35.3		 4umjA-3p8lA:
44.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		5 SER A  78
LEU A  79
ASP A  82
MET A 152
GLN A 156
 None
 0.93A 4umjA-3p8rA:
34.8		 4umjA-3p8rA:
52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p8r GERANYLTRANSTRANSFER
ASE

(Vibrio cholerae) 		PF00348
(polyprenyl_synt) 		4 SER A  78
LEU A  79
MET A 152
LYS A 179
 None
 0.85A 4umjA-3p8rA:
34.8		 4umjA-3p8rA:
52.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 LEU A  84
ASP A  87
ARG A  96
LYS A 174
 None
None
CIT  A 326 ( 4.8A)
None
 0.99A 4umjA-3pkoA:
26.6		 4umjA-3pkoA:
27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 LEU A  84
ASP A  91
ARG A  96
LYS A 174
 None
None
CIT  A 326 ( 4.8A)
None
 0.70A 4umjA-3pkoA:
26.6		 4umjA-3pkoA:
27.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		7 SER A  88
LEU A  89
ASP A  92
ASP A  98
ARG A 103
GLN A 163
LYS A 186
 DMA  A 501 (-3.4A)
DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
 0.69A 4umjA-3q1oA:
29.3		 4umjA-3q1oA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		7 SER A  88
LEU A  89
ASP A  92
ASP A  98
ARG A 103
MET A 159
LYS A 186
 DMA  A 501 (-3.4A)
DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 ( 3.8A)
DMA  A 501 (-3.1A)
 0.75A 4umjA-3q1oA:
29.3		 4umjA-3q1oA:
35.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 191
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
 0.99A 4umjA-3qqvA:
27.6		 4umjA-3qqvA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 105
ASP A 108
ASP A 112
ARG A 117
LYS A 215
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
 0.51A 4umjA-3qqvA:
27.6		 4umjA-3qqvA:
30.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		4 SER A  73
LEU A  74
ASP A  77
LYS A 162
 None
 0.90A 4umjA-3tc1A:
22.8		 4umjA-3tc1A:
24.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		5 ASP A  88
ASP A  94
ARG A  99
GLN A 162
LYS A 185
 None
 1.22A 4umjA-3ts7A:
38.0		 4umjA-3ts7A:
57.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		5 LEU A  85
ASP A  88
ASP A  94
ARG A  99
GLN A 162
 None
 1.08A 4umjA-3ts7A:
38.0		 4umjA-3ts7A:
57.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		6 SER A  84
ASP A  94
ARG A  99
MET A 158
GLN A 162
LYS A 185
 None
 0.71A 4umjA-3ts7A:
38.0		 4umjA-3ts7A:
57.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		6 SER A  84
LEU A  85
ASP A  94
ARG A  99
MET A 158
GLN A 162
 None
 0.45A 4umjA-3ts7A:
38.0		 4umjA-3ts7A:
57.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		6 SER A  87
LEU A  88
ASP A  97
ARG A 102
MET A 159
GLN A 163
 None
 0.42A 4umjA-3ucaA:
34.8		 4umjA-3ucaA:
38.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A  81
ASP A  84
ASP A  88
ARG A  93
LYS A 170
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 1.06A 4umjA-3wjoA:
29.0		 4umjA-3wjoA:
29.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		8 SER A  79
LEU A  80
ASP A  83
ASP A  89
ARG A  94
MET A 153
GLN A 157
LYS A 180
 GPP  A1297 (-3.9A)
None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 ( 4.6A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.34A 4umjA-3zouA:
47.3		 4umjA-3zouA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 LEU A 368
ASP A 367
ARG A 715
GLN A 450
 GOL  A1737 ( 4.9A)
GOL  A1737 (-2.8A)
GOL  A1737 (-3.3A)
None
 1.00A 4umjA-4c1oA:
2.2		 4umjA-4c1oA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1t SUGAR TRANSPORTER
SOLUTE-BINDING
PROTEIN

(Bifidobacterium
animalis) 		PF01547
(SBP_bac_1) 		4 SER A 153
LEU A 156
ASP A 155
MET A 292
 None
 0.89A 4umjA-4c1tA:
undetectable		 4umjA-4c1tA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
 0.57A 4umjA-4e1eA:
23.4		 4umjA-4e1eA:
25.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		6 SER A  79
LEU A  80
ASP A  83
ASP A  89
MET A 151
LYS A 178
 None
 0.59A 4umjA-4f62A:
37.1		 4umjA-4f62A:
50.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		5 SER A  79
LEU A  80
ASP A  83
GLN A 155
LYS A 178
 None
 1.21A 4umjA-4f62A:
37.1		 4umjA-4f62A:
50.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 SER A  82
ASP A  86
ASP A  90
ARG A  95
GLN A 147
 GER  A 301 (-4.5A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
 0.71A 4umjA-4fp4A:
24.8		 4umjA-4fp4A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		6 SER A  82
LEU A  83
ASP A  86
ASP A  90
ARG A  95
LYS A 162
 GER  A 301 (-4.5A)
UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.8A)
 0.92A 4umjA-4fp4A:
24.8		 4umjA-4fp4A:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 LEU A  82
ASP A  85
ASP A  89
ARG A  94
LYS A 184
 None
 0.68A 4umjA-4gp1A:
28.8		 4umjA-4gp1A:
33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 SER A  81
LEU A  82
ASP A  85
ASP A  89
ARG A  94
 None
 0.69A 4umjA-4gp1A:
28.8		 4umjA-4gp1A:
33.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
 0.50A 4umjA-4jzxA:
24.1		 4umjA-4jzxA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		5 LEU A  94
ASP A  97
ARG A 106
GLN A 165
LYS A 194
 None
 0.72A 4umjA-4kk2A:
23.3		 4umjA-4kk2A:
25.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		4 LEU A  83
ASP A  92
ARG A  97
LYS A 184
 None
 0.89A 4umjA-4kkmA:
37.5		 4umjA-4kkmA:
46.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		6 SER A  82
LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
 None
 0.72A 4umjA-4kkmA:
37.5		 4umjA-4kkmA:
46.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		6 SER A  82
LEU A  83
ASP A  86
ASP A  92
ARG A  97
MET A 155
 None
 0.70A 4umjA-4kkmA:
37.5		 4umjA-4kkmA:
46.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		7 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.74A 4umjA-4lfeA:
33.0		 4umjA-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		7 SER A  74
LEU A  75
ASP A  78
ASP A  84
ARG A  89
MET A 145
LYS A 172
 IPE  A 301 (-3.4A)
IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 4.2A)
IPE  A 301 (-3.0A)
 0.78A 4umjA-4lfeA:
33.0		 4umjA-4lfeA:
40.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		8 SER A  76
LEU A  77
ASP A  80
ASP A  86
ARG A  91
MET A 149
GLN A 153
LYS A 178
 GST  A 302 (-3.9A)
None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 ( 4.1A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
 0.35A 4umjA-4llsA:
34.9		 4umjA-4llsA:
43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mem UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 11

(Rattus
norvegicus) 		PF06337
(DUSP)
PF14836
(Ubiquitin_3) 		4 SER A 169
LEU A 172
ASP A 171
GLN A 207
 None
 1.06A 4umjA-4memA:
undetectable		 4umjA-4memA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
 0.68A 4umjA-4p0vA:
23.8		 4umjA-4p0vA:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl0 MICROCIN-J25 EXPORT
ATP-BINDING/PERMEASE
PROTEIN MCJD

(Escherichia
coli) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 SER A 207
LEU A 208
ASP A 211
ARG A 231
 None
 1.02A 4umjA-4pl0A:
undetectable		 4umjA-4pl0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 LEU A 346
ASP A 345
ARG A 693
GLN A 428
 None
TRS  A 803 (-2.7A)
TRS  A 803 (-3.4A)
None
 1.07A 4umjA-4rhhA:
2.4		 4umjA-4rhhA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
 0.75A 4umjA-4rxeA:
23.5		 4umjA-4rxeA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s13 FERULIC ACID
DECARBOXYLASE 1

(Saccharomyces
cerevisiae) 		PF01977
(UbiD) 		4 SER A  60
LEU A  63
ASP A  62
ASP A 310
 None
 1.02A 4umjA-4s13A:
undetectable		 4umjA-4s13A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5c LRRTM

(synthetic
construct) 		PF13855
(LRR_8) 		4 SER A 305
LEU A 307
ASP A 318
ASP A 321
 None
 1.01A 4umjA-5a5cA:
undetectable		 4umjA-5a5cA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		4 SER A  96
LEU A 104
ASP A  99
ARG A 225
 None
 0.99A 4umjA-5aeeA:
undetectable		 4umjA-5aeeA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
 0.61A 4umjA-5ahuB:
16.8		 4umjA-5ahuB:
23.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		6 SER A  82
ASP A  92
ARG A  97
MET A 156
GLN A 160
LYS A 183
 None
 0.96A 4umjA-5aypA:
35.3		 4umjA-5aypA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		7 SER A  82
LEU A  83
ASP A  86
ASP A  92
ARG A  97
MET A 156
GLN A 160
 None
 0.72A 4umjA-5aypA:
35.3		 4umjA-5aypA:
45.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 SER A  88
LEU A  89
ASP A  98
ARG A 103
 None
 0.38A 4umjA-5e8hA:
38.5		 4umjA-5e8hA:
46.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 SER A  87
LEU A  88
ASP A  97
GLN A 163
 None
 0.74A 4umjA-5e8kA:
36.5		 4umjA-5e8kA:
42.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A  88
ASP A  91
ASP A  97
ARG A 102
GLN A 166
 None
 1.08A 4umjA-5e8lA:
38.4		 4umjA-5e8lA:
46.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 SER A  87
LEU A  88
ASP A  91
ASP A  97
ARG A 102
 None
 0.71A 4umjA-5e8lA:
38.4		 4umjA-5e8lA:
46.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  86
ARG A  91
LYS A 168
 PO4  A 501 (-4.5A)
None
PO4  A 501 ( 4.9A)
None
 0.85A 4umjA-5h9dA:
27.9		 4umjA-5h9dA:
28.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		5 ASP A 126
ASP A 130
ARG A 135
GLN A 195
LYS A 243
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
 0.72A 4umjA-5hn7A:
22.6		 4umjA-5hn7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-FOLD
MODIFIER 1
UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5

(Homo sapiens) 		PF00899
(ThiF)
PF03671
(Ufm1) 		4 SER C  12
LEU C  10
ASP C  13
GLN A 289
 None
 0.95A 4umjA-5iaaC:
undetectable		 4umjA-5iaaC:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6v AMYLOSUCRASE

(Neisseria
polysaccharea) 		no annotation 4 SER A 143
ASP A 144
ARG A 513
GLN A 254
 None
TRS  A 701 (-2.8A)
None
TRS  A 701 (-4.2A)
 1.00A 4umjA-5n6vA:
undetectable		 4umjA-5n6vA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 SER A 757
ASP A 756
GLN A 743
LYS A 763
 None
 0.85A 4umjA-5ngyA:
undetectable		 4umjA-5ngyA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oik TRANSCRIPTION
ELONGATION FACTOR
SPT5

(Homo sapiens) 		PF00467
(KOW)
PF03439
(Spt5-NGN) 		4 SER Z 504
LEU Z 506
ASP Z 505
LYS Z 479
 None
 0.93A 4umjA-5oikZ:
undetectable		 4umjA-5oikZ:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 21

(Saccharomyces
cerevisiae) 		PF11221
(Med21) 		4 LEU W  68
ASP W  65
MET W  15
GLN W  18
 None
 1.03A 4umjA-5svaW:
undetectable		 4umjA-5svaW:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6m HISTIDINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		no annotation 4 SER A 323
LEU A 324
ASP A 239
LYS A 243
 None
 1.01A 4umjA-5w6mA:
undetectable		 4umjA-5w6mA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 ASP A 147
ASP A 151
ARG A 156
GLN A 215
LYS A 244
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
 0.65A 4umjA-6b07A:
23.2		 4umjA-6b07A:
12.33