SIMILAR PATTERNS OF AMINO ACIDS FOR 4UHX_A_RTZA3009_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 HIS A 184
GLU A 181
ASP A 180
SER A 481
 None
 1.10A 4uhxA-1bhyA:
1.2		 4uhxA-1bhyA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 HIS A 393
ASP A 396
SER A 399
ARG A 395
 None
 1.07A 4uhxA-1c2oA:
0.0		 4uhxA-1c2oA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 GLU A  35
ASP A  37
SER A 364
ARG A 297
 None
 1.16A 4uhxA-1djuA:
undetectable		 4uhxA-1djuA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnw GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 HIS A 172
GLU A 106
SER A 115
PRO A 112
 None
None
GTX  A 213 ( 4.0A)
None
 1.19A 4uhxA-1gnwA:
undetectable		 4uhxA-1gnwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 GLU A 558
ASP A 561
ARG A 417
PRO A 554
 None
 1.14A 4uhxA-1iduA:
undetectable		 4uhxA-1iduA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		4 GLU B 560
ASP B 559
SER B 597
ARG B 598
 None
 0.99A 4uhxA-1jmuB:
undetectable		 4uhxA-1jmuB:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 GLU A 294
ASP A 290
ARG A 289
ARG A 292
 None
 0.86A 4uhxA-1kczA:
1.8		 4uhxA-1kczA:
14.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 571
SER A1051
PRO A1057
TRP A1113
 None
 1.01A 4uhxA-1n5xA:
41.7		 4uhxA-1n5xA:
50.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 GLU A 653
ASP A 667
ARG A 682
ARG A 666
 None
 1.19A 4uhxA-1p15A:
0.7		 4uhxA-1p15A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		4 HIS A 253
ASP A 256
ARG A 255
ARG A 254
 None
 1.19A 4uhxA-1t8hA:
undetectable		 4uhxA-1t8hA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc7 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF13899
(Thioredoxin_7) 		4 HIS A 119
ASP A 122
ARG A 121
PRO A 125
 None
 1.12A 4uhxA-1uc7A:
undetectable		 4uhxA-1uc7A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vey PEPTIDE DEFORMYLASE

(Leptospira
interrogans) 		PF01327
(Pep_deformylase) 		4 HIS A 147
GLU A 144
ASP A 146
ARG A 156
 ZN  A1513 (-3.6A)
EPE  A1716 (-3.1A)
None
None
 1.16A 4uhxA-1veyA:
undetectable		 4uhxA-1veyA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		4 ASP A 169
ARG A  35
PRO A 104
TRP A 102
 None
MLY  A 172 ( 3.6A)
None
MLY  A 221 ( 3.8A)
 0.95A 4uhxA-1vk1A:
undetectable		 4uhxA-1vk1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ASP A 415
SER A 419
ARG A 418
ARG A 417
 None
 1.17A 4uhxA-1w78A:
undetectable		 4uhxA-1w78A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 HIS E 522
GLU E 519
ARG E 521
PRO E 517
 None
 1.18A 4uhxA-1ye9E:
undetectable		 4uhxA-1ye9E:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 HIS A 342
ASP A 341
ARG A 343
PRO A 346
 None
 1.09A 4uhxA-2a8xA:
2.7		 4uhxA-2a8xA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 HIS A 701
ASP A 744
SER A 670
ARG A 675
PRO A 852
 None
 1.25A 4uhxA-2c3oA:
undetectable		 4uhxA-2c3oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 ASP A  90
ARG A  88
PRO A  98
TRP A  93
 None
 1.06A 4uhxA-2d5wA:
undetectable		 4uhxA-2d5wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 4 HIS A 323
ASP A 322
ARG A 320
PRO A 354
 None
 1.21A 4uhxA-2de2A:
undetectable		 4uhxA-2de2A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 ASP A 299
ARG A 297
ARG A 296
PRO A 389
 None
 1.22A 4uhxA-2fuqA:
1.0		 4uhxA-2fuqA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 HIS A 186
ASP A 185
SER A 165
ARG A 166
 None
 1.22A 4uhxA-2i44A:
undetectable		 4uhxA-2i44A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib0 CONSERVED
HYPOTHETICAL ALANINE
RICH PROTEIN

(Mycobacterium
tuberculosis) 		PF14530
(DUF4439) 		4 HIS A  64
ASP A  67
ARG A  66
ARG A  65
 None
 1.05A 4uhxA-2ib0A:
undetectable		 4uhxA-2ib0A:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 328
ASP A 329
SER A 200
TRP A 203
 None
 1.23A 4uhxA-2j2mA:
undetectable		 4uhxA-2j2mA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A  47
ASP A  49
ARG A 187
PRO A  46
 None
 1.07A 4uhxA-2nz9A:
1.6		 4uhxA-2nz9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 GLU A  29
ASP A  33
ARG A 205
PRO A  30
 None
 1.18A 4uhxA-2pcqA:
undetectable		 4uhxA-2pcqA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr6 IMP
DEHYDROGENASE/GMP
REDUCTASE

(Corynebacterium
glutamicum) 		PF00478
(IMPDH) 		4 GLU A 253
ASP A 249
ARG A 248
ARG A 247
 None
 1.22A 4uhxA-2qr6A:
undetectable		 4uhxA-2qr6A:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 HIS A 720
ASP A 667
ARG A 719
PRO A 661
 None
 0.76A 4uhxA-2wzsA:
undetectable		 4uhxA-2wzsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 HIS A 720
ASP A 667
ARG A 719
PRO A 664
 None
 1.06A 4uhxA-2wzsA:
undetectable		 4uhxA-2wzsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 GLU A 258
ASP A 281
SER A 285
PRO A 240
 None
 0.89A 4uhxA-3a64A:
undetectable		 4uhxA-3a64A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 HIS A 548
GLU A  76
ASP A 549
ARG A 188
 None
None
None
SO4  A1001 (-3.9A)
 1.01A 4uhxA-3azqA:
undetectable		 4uhxA-3azqA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 HIS A  10
GLU A  11
ASP A   9
SER A   1
 None
 1.19A 4uhxA-3b4tA:
undetectable		 4uhxA-3b4tA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cih PUTATIVE
ALPHA-RHAMNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ASP A 337
ARG A 336
ARG A 338
PRO A  47
 TRS  A 800 ( 4.3A)
TRS  A 800 (-4.1A)
None
None
 1.13A 4uhxA-3cihA:
undetectable		 4uhxA-3cihA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d22 THIOREDOXIN H-TYPE

(Populus
trichocarpa x
Populus
deltoides) 		PF00085
(Thioredoxin) 		4 SER A  54
ARG A  56
ARG A  62
PRO A 101
 None
 1.08A 4uhxA-3d22A:
undetectable		 4uhxA-3d22A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 GLU A  10
ASP A  32
ARG A 150
TRP A  45
 None
None
SO4  A2003 (-3.7A)
BTN  A2001 ( 3.7A)
 1.21A 4uhxA-3efsA:
undetectable		 4uhxA-3efsA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A  89
SER A  95
ARG A 101
PRO A  92
 None
 1.01A 4uhxA-3ho8A:
2.4		 4uhxA-3ho8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 GLU A 272
ASP A 271
ARG A 694
PRO A 621
 None
 1.15A 4uhxA-3ksyA:
undetectable		 4uhxA-3ksyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		4 GLU A 453
ASP A 476
ARG A 525
ARG A 451
 None
 1.19A 4uhxA-3n9vA:
undetectable		 4uhxA-3n9vA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 GLU A  72
SER A  78
ARG A  82
PRO A  75
 None
 1.15A 4uhxA-3oqpA:
undetectable		 4uhxA-3oqpA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6a UNCHARACTERIZED
PROTEIN

(Staphylococcus
saprophyticus) 		PF08327
(AHSA1) 		4 SER A  33
ARG A  47
PRO A  23
TRP A  38
 None
 1.18A 4uhxA-3q6aA:
undetectable		 4uhxA-3q6aA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcz DNA REPAIR PROTEIN
RAD60

(Schizosaccharomyces
pombe) 		PF11976
(Rad60-SLD) 		4 GLU A 344
ASP A 345
SER A 340
ARG A 339
 None
 1.13A 4uhxA-3rczA:
3.1		 4uhxA-3rczA:
4.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ASP C 571
SER C1051
PRO C1057
TRP C1113
 None
 1.00A 4uhxA-3sr6C:
45.3		 4uhxA-3sr6C:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 GLU A 148
ASP A 150
ARG A 143
PRO A 321
 None
 1.22A 4uhxA-3sxfA:
undetectable		 4uhxA-3sxfA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		4 GLU A 117
ASP A 118
ARG A  90
PRO A 147
 None
 1.14A 4uhxA-3t7vA:
undetectable		 4uhxA-3t7vA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ASP A 255
SER A 210
ARG A 187
PRO A 184
 None
 1.09A 4uhxA-3tmaA:
undetectable		 4uhxA-3tmaA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphingomonas
wittichii) 		PF00903
(Glyoxalase) 		4 GLU A 178
ASP A 180
ARG A 173
PRO A 282
 None
 1.18A 4uhxA-3vb0A:
undetectable		 4uhxA-3vb0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 GLU A 578
ASP A 534
ARG A 230
PRO A 539
 None
 1.22A 4uhxA-3vtrA:
undetectable		 4uhxA-3vtrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 HIS A 230
GLU A 349
ARG A 220
PRO A 337
 None
 1.19A 4uhxA-3w4rA:
undetectable		 4uhxA-3w4rA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLU A 101
SER A  89
ARG A  46
TRP A  29
 None
 1.15A 4uhxA-3w5nA:
undetectable		 4uhxA-3w5nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 HIS A 230
GLU A 349
ARG A 220
PRO A 337
 None
 1.19A 4uhxA-3wl1A:
undetectable		 4uhxA-3wl1A:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 578
SER A1056
ARG A1057
PRO A1062
 None
 0.52A 4uhxA-3zyvA:
42.5		 4uhxA-3zyvA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 578
SER A1056
PRO A1062
TRP A1118
 None
 1.03A 4uhxA-3zyvA:
42.5		 4uhxA-3zyvA:
61.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 GLU A 555
ARG A 553
ARG A 520
PRO A 468
 None
 1.10A 4uhxA-4cakA:
undetectable		 4uhxA-4cakA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcr GAMMA-B CRYSTALLIN

(Bos taurus) 		PF00030
(Crystall) 		4 ASP A  97
SER A 123
ARG A 152
ARG A 153
 None
 1.21A 4uhxA-4gcrA:
undetectable		 4uhxA-4gcrA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgz CCBJ

(Streptomyces
caelestis) 		PF13649
(Methyltransf_25) 		4 GLU A 235
ASP A  29
ARG A  55
ARG A  31
 None
 1.13A 4uhxA-4hgzA:
undetectable		 4uhxA-4hgzA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG

(Schizosaccharomyces
pombe) 		PF04388
(Hamartin) 		4 HIS A 301
ASP A 241
ARG A 204
PRO A 244
 None
 1.22A 4uhxA-4kk1A:
undetectable		 4uhxA-4kk1A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		4 GLU A  43
ASP A  41
SER A  37
ARG A  66
 None
 1.23A 4uhxA-4mdvA:
undetectable		 4uhxA-4mdvA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 GLU A 158
ASP A 157
SER A 216
PRO A 214
 None
MN  A 601 ( 2.5A)
None
None
 0.86A 4uhxA-4nhyA:
undetectable		 4uhxA-4nhyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pel PENICILLIN G ACYLASE
SUBUNIT ALPHA
PENICILLIN G ACYLASE
SUBUNIT BETA

(Kluyvera
cryocrescens) 		PF01804
(Penicil_amidase) 		4 GLU A  88
ASP A  23
ARG A  26
ARG B 557
 None
 1.20A 4uhxA-4pelA:
undetectable		 4uhxA-4pelA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0n PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 GLU A 632
ASP A 730
ARG A 729
ARG A 728
 None
 1.11A 4uhxA-4q0nA:
undetectable		 4uhxA-4q0nA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		4 GLU A 211
ASP A 210
ARG A  54
TRP A  60
 None
 1.12A 4uhxA-4rzzA:
undetectable		 4uhxA-4rzzA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 ASP A 297
SER A 301
ARG A 340
TRP A 302
 None
 0.86A 4uhxA-4u3aA:
undetectable		 4uhxA-4u3aA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wva UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		PF01204
(Trehalase) 		4 HIS A 192
ASP A 189
ARG A 187
ARG A 188
 None
 1.10A 4uhxA-4wvaA:
undetectable		 4uhxA-4wvaA:
15.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 571
SER A1051
ARG A1052
PRO A1057
 None
 0.70A 4uhxA-4yswA:
42.2		 4uhxA-4yswA:
49.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 571
SER A1051
PRO A1057
TRP A1113
 None
 1.02A 4uhxA-4yswA:
42.2		 4uhxA-4yswA:
49.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLU A 570
ASP A 571
SER A1051
ARG A1052
 None
 1.18A 4uhxA-4yswA:
42.2		 4uhxA-4yswA:
49.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 HIS A  55
ASP A  58
ARG A 104
TRP A 315
 None
 1.20A 4uhxA-4yztA:
undetectable		 4uhxA-4yztA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrv MINCLE CRD

(Bos taurus) 		PF00059
(Lectin_C) 		4 ASP A 165
SER A 184
ARG A 182
PRO A 187
 None
None
4RS  A 301 (-3.3A)
None
 1.07A 4uhxA-4zrvA:
undetectable		 4uhxA-4zrvA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		4 ASP A  96
SER A 276
ARG A 279
PRO A 322
 None
 1.22A 4uhxA-4zz7A:
undetectable		 4uhxA-4zz7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		4 HIS A 215
ASP A 242
ARG A 179
PRO A 208
 None
 1.18A 4uhxA-5ap9A:
undetectable		 4uhxA-5ap9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		4 GLU C  25
ASP C 224
ARG C 199
PRO C  26
 None
 1.22A 4uhxA-5b57C:
undetectable		 4uhxA-5b57C:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2

(Mus musculus) 		PF06046
(Sec6) 		4 GLU A 158
ASP A 159
ARG A  96
TRP A 179
 None
 1.12A 4uhxA-5b86A:
undetectable		 4uhxA-5b86A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		4 HIS A 490
ASP A 491
ARG A 516
PRO A 497
 None
None
SO4  A 702 (-3.1A)
None
 1.21A 4uhxA-5bp8A:
undetectable		 4uhxA-5bp8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		4 HIS A  65
GLU A  61
ARG A 312
PRO A 310
 None
 1.10A 4uhxA-5c9iA:
undetectable		 4uhxA-5c9iA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 GLU A 449
SER A 488
ARG A 409
PRO A 485
 None
 1.00A 4uhxA-5dqfA:
undetectable		 4uhxA-5dqfA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 ASP A 578
SER A1060
ARG A1061
ARG A1064
PRO A1066
TRP A1122
 None
 0.81A 4uhxA-5epgA:
48.0		 4uhxA-5epgA:
99.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 GLU A 577
ASP A 578
SER A1060
ARG A1061
PRO A1066
TRP A1122
 None
 1.39A 4uhxA-5epgA:
48.0		 4uhxA-5epgA:
99.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 HIS A 575
ASP A 578
SER A1060
ARG A1061
PRO A1066
TRP A1122
 None
 0.92A 4uhxA-5epgA:
48.0		 4uhxA-5epgA:
99.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli) 		PF03515
(Cloacin) 		4 GLU A 336
ASP A 337
ARG A 432
ARG A 433
 None
 1.06A 4uhxA-5ew5A:
undetectable		 4uhxA-5ew5A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF2

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 HIS A 172
GLU A 106
SER A 114
PRO A 112
 None
 0.95A 4uhxA-5ey6A:
undetectable		 4uhxA-5ey6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 HIS A 169
GLU A 103
SER A 112
PRO A 109
 None
 1.19A 4uhxA-5f05A:
undetectable		 4uhxA-5f05A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLU A 974
ASP A1021
SER A1023
ARG A1022
 None
 1.12A 4uhxA-5fkuA:
undetectable		 4uhxA-5fkuA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuz 645 FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP H 109
ARG H  97
PRO H 106
TRP H  47
 None
 1.17A 4uhxA-5fuzH:
undetectable		 4uhxA-5fuzH:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gam PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08082
(PRO8NT)
PF08083
(PROCN) 		4 GLU A 210
ASP A 498
ARG A 495
ARG A 207
 None
A  U  82 ( 3.9A)
C  U 112 ( 3.0A)
U  U  33 ( 3.2A)
 1.22A 4uhxA-5gamA:
undetectable		 4uhxA-5gamA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 GLU A 450
SER A 489
ARG A 410
PRO A 486
 None
 1.15A 4uhxA-5ghkA:
undetectable		 4uhxA-5ghkA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 GLU A 421
ASP A  96
SER A 448
PRO A 452
 MN  A 501 (-2.0A)
None
None
None
 0.81A 4uhxA-5hucA:
undetectable		 4uhxA-5hucA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2b PEPTIDE DEFORMYLASE

(Burkholderia
ambifaria) 		PF01327
(Pep_deformylase) 		4 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 ZN  A 201 ( 3.5A)
BB2  A 202 (-2.2A)
EDO  A 203 ( 4.8A)
EDO  A 203 (-2.8A)
 1.17A 4uhxA-5i2bA:
undetectable		 4uhxA-5i2bA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0u CAPSID PROTEIN VP3

(Rhinovirus C) 		PF00073
(Rhv) 		4 HIS B 184
ASP B 180
ARG B 176
ARG B 175
 None
 1.21A 4uhxA-5k0uB:
undetectable		 4uhxA-5k0uB:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kob PEPTIDE DEFORMYLASE

(Paraburkholderia
xenovorans) 		PF01327
(Pep_deformylase) 		4 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 FE2  A 201 (-3.4A)
FE2  A 201 ( 4.2A)
FMT  A 204 (-3.7A)
None
 1.16A 4uhxA-5kobA:
undetectable		 4uhxA-5kobA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 ASP A 113
ARG A 111
PRO A 121
TRP A 116
 None
 1.05A 4uhxA-5kztA:
undetectable		 4uhxA-5kztA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 GLU A 598
ASP A 600
ARG A 476
PRO A 594
 None
 0.92A 4uhxA-5l9wA:
undetectable		 4uhxA-5l9wA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 ASP A1290
SER A1293
ARG A1600
ARG A1291
 None
 1.02A 4uhxA-5lcwA:
undetectable		 4uhxA-5lcwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A 819
ASP A 821
SER A 824
ARG A 711
 None
 1.19A 4uhxA-5n0cA:
2.5		 4uhxA-5n0cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 CAPSID VERTEX
PROTEIN GP24

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 GLU a 199
ASP a 200
ARG a  29
PRO a 195
 None
 1.14A 4uhxA-5vf3a:
undetectable		 4uhxA-5vf3a:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfz GP33

(Mycobacterium
virus Brujita) 		no annotation 4 HIS A 210
SER A 215
ARG A 212
ARG A 213
 None
 1.20A 4uhxA-5vfzA:
undetectable		 4uhxA-5vfzA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqm PA41 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ASP H 107
SER H  99
ARG H  98
PRO H 104
 None
 0.92A 4uhxA-5vqmH:
undetectable		 4uhxA-5vqmH:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxo PERIPLASMIC
BETA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 4 GLU A 519
SER A 525
ARG A 527
ARG A 478
 None
 1.21A 4uhxA-5xxoA:
undetectable		 4uhxA-5xxoA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3b DIXIN

(Mus musculus) 		PF00778
(DIX) 		4 HIS A 431
GLU A 469
ASP A 470
TRP A 466
 None
 1.16A 4uhxA-5y3bA:
3.5		 4uhxA-5y3bA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 HIS A1702
GLU A1699
ASP A1698
PRO A1891
 None
 1.12A 4uhxA-6bq1A:
undetectable		 4uhxA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 HIS A 730
ASP A1203
ARG A 676
PRO A 733
 None
 1.18A 4uhxA-6en4A:
undetectable		 4uhxA-6en4A:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 HIS A 191
GLU A 518
SER A 522
ARG A 523
 None
 1.15A 4uhxA-6es9A:
undetectable		 4uhxA-6es9A:
4.93