SIMILAR PATTERNS OF AMINO ACIDS FOR 4UHX_A_LZUA3008

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgf STAT-4

(Mus musculus) 		PF02865
(STAT_int) 		4 GLU A  66
ASP A  65
ARG A  87
TRP A  43
 None
 1.18A 4uhxA-1bgfA:
undetectable		 4uhxA-1bgfA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 HIS A 184
GLU A 181
ASP A 180
SER A 481
 None
 1.10A 4uhxA-1bhyA:
1.2		 4uhxA-1bhyA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		4 HIS A 393
ASP A 396
SER A 399
ARG A 395
 None
 1.07A 4uhxA-1c2oA:
0.0		 4uhxA-1c2oA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 4 GLU A 201
ASP A 203
SER A 241
TRP A  46
 None
None
FOH  A 401 (-3.3A)
None
 1.20A 4uhxA-1dgpA:
undetectable		 4uhxA-1dgpA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dju AROMATIC
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 GLU A  35
ASP A  37
SER A 364
ARG A 297
 None
 1.16A 4uhxA-1djuA:
undetectable		 4uhxA-1djuA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 HIS A 320
SER A 418
TRP A 441
TRP A 444
 None
 1.22A 4uhxA-1fbwA:
undetectable		 4uhxA-1fbwA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnw GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 HIS A 172
GLU A 106
SER A 115
PRO A 112
 None
None
GTX  A 213 ( 4.0A)
None
 1.19A 4uhxA-1gnwA:
undetectable		 4uhxA-1gnwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 HIS A  46
SER A 376
ARG A 375
TRP A 393
 None
 0.92A 4uhxA-1i5pA:
undetectable		 4uhxA-1i5pA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		4 GLU A 558
ASP A 561
ARG A 417
PRO A 554
 None
 1.14A 4uhxA-1iduA:
undetectable		 4uhxA-1iduA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		4 GLU B 560
ASP B 559
SER B 597
ARG B 598
 None
 0.99A 4uhxA-1jmuB:
undetectable		 4uhxA-1jmuB:
18.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 571
SER A1051
PRO A1057
TRP A1113
 None
 1.01A 4uhxA-1n5xA:
41.7		 4uhxA-1n5xA:
50.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ASP A 571
SER A1051
PRO A1057
TRP A1116
 None
 0.63A 4uhxA-1n5xA:
41.7		 4uhxA-1n5xA:
50.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc7 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF13899
(Thioredoxin_7) 		4 HIS A 119
ASP A 122
ARG A 121
PRO A 125
 None
 1.12A 4uhxA-1uc7A:
undetectable		 4uhxA-1uc7A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vey PEPTIDE DEFORMYLASE

(Leptospira
interrogans) 		PF01327
(Pep_deformylase) 		4 HIS A 147
GLU A 144
ASP A 146
ARG A 156
 ZN  A1513 (-3.6A)
EPE  A1716 (-3.1A)
None
None
 1.16A 4uhxA-1veyA:
undetectable		 4uhxA-1veyA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vk1 CONSERVED
HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		PF02195
(ParBc) 		4 ASP A 169
ARG A  35
PRO A 104
TRP A 102
 None
MLY  A 172 ( 3.6A)
None
MLY  A 221 ( 3.8A)
 0.95A 4uhxA-1vk1A:
undetectable		 4uhxA-1vk1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a8x DIHYDROLIPOYL
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 HIS A 342
ASP A 341
ARG A 343
PRO A 346
 None
 1.09A 4uhxA-2a8xA:
2.7		 4uhxA-2a8xA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 HIS A 701
ASP A 744
SER A 670
PRO A 852
 None
 0.91A 4uhxA-2c3oA:
undetectable		 4uhxA-2c3oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 ASP A  90
ARG A  88
PRO A  98
TRP A  93
 None
 1.06A 4uhxA-2d5wA:
undetectable		 4uhxA-2d5wA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 4 HIS A 323
ASP A 322
ARG A 320
PRO A 354
 None
 1.21A 4uhxA-2de2A:
undetectable		 4uhxA-2de2A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 HIS A 186
ASP A 185
SER A 165
ARG A 166
 None
 1.22A 4uhxA-2i44A:
undetectable		 4uhxA-2i44A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j2m CATALASE

(Exiguobacterium
oxidotolerans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLU A 328
ASP A 329
SER A 200
TRP A 203
 None
 1.23A 4uhxA-2j2mA:
undetectable		 4uhxA-2j2mA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD

(Homo sapiens) 		PF00619
(CARD)
PF02758
(PYRIN) 		4 GLU A 193
ASP A 191
ARG A 125
TRP A 169
 None
 1.15A 4uhxA-2kn6A:
undetectable		 4uhxA-2kn6A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nz9 BOTULINUM NEUROTOXIN
TYPE A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A  47
ASP A  49
ARG A 187
PRO A  46
 None
 1.07A 4uhxA-2nz9A:
1.6		 4uhxA-2nz9A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 GLU A  29
ASP A  33
ARG A 205
PRO A  30
 None
 1.18A 4uhxA-2pcqA:
undetectable		 4uhxA-2pcqA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwb PUTATIVE
O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22)
PF01163
(RIO1) 		4 GLU A 478
ASP A 477
ARG A 516
TRP A 503
 None
 1.19A 4uhxA-2vwbA:
undetectable		 4uhxA-2vwbA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 HIS A 720
ASP A 667
ARG A 719
PRO A 661
 None
 0.76A 4uhxA-2wzsA:
undetectable		 4uhxA-2wzsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 HIS A 720
ASP A 667
ARG A 719
PRO A 664
 None
 1.06A 4uhxA-2wzsA:
undetectable		 4uhxA-2wzsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a64 CELLOBIOHYDROLASE

(Coprinopsis
cinerea) 		PF01341
(Glyco_hydro_6) 		4 GLU A 258
ASP A 281
SER A 285
PRO A 240
 None
 0.89A 4uhxA-3a64A:
undetectable		 4uhxA-3a64A:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 HIS A 548
GLU A  76
ASP A 549
ARG A 188
 None
None
None
SO4  A1001 (-3.9A)
 1.01A 4uhxA-3azqA:
undetectable		 4uhxA-3azqA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 HIS A  10
GLU A  11
ASP A   9
SER A   1
 None
 1.19A 4uhxA-3b4tA:
undetectable		 4uhxA-3b4tA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		4 HIS A   4
ASP A  83
ARG A  68
TRP A  53
 None
 1.17A 4uhxA-3dr2A:
undetectable		 4uhxA-3dr2A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 GLU A  10
ASP A  32
ARG A 150
TRP A  45
 None
None
SO4  A2003 (-3.7A)
BTN  A2001 ( 3.7A)
 1.21A 4uhxA-3efsA:
undetectable		 4uhxA-3efsA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		4 ASP A 302
SER A  57
ARG A 300
TRP A 282
 None
 1.12A 4uhxA-3fhaA:
2.6		 4uhxA-3fhaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		4 GLU A 318
ASP A 302
ARG A 300
TRP A 282
 None
 1.08A 4uhxA-3fhaA:
2.6		 4uhxA-3fhaA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ho8 PYRUVATE CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 ASP A  89
SER A  95
ARG A 101
PRO A  92
 None
 1.01A 4uhxA-3ho8A:
2.3		 4uhxA-3ho8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksy SON OF SEVENLESS
HOMOLOG 1

(Homo sapiens) 		PF00125
(Histone)
PF00169
(PH)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
PF00621
(RhoGEF) 		4 GLU A 272
ASP A 271
ARG A 694
PRO A 621
 None
 1.15A 4uhxA-3ksyA:
undetectable		 4uhxA-3ksyA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7h PUTIDACIN L1

(Pseudomonas
putida) 		PF01453
(B_lectin) 		4 ARG A 231
PRO A 135
TRP A 187
TRP A 218
 None
 0.99A 4uhxA-3m7hA:
undetectable		 4uhxA-3m7hA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqp PUTATIVE
ISOCHORISMATASE

(Paraburkholderia
xenovorans) 		PF00857
(Isochorismatase) 		4 GLU A  72
SER A  78
ARG A  82
PRO A  75
 None
 1.15A 4uhxA-3oqpA:
undetectable		 4uhxA-3oqpA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6a UNCHARACTERIZED
PROTEIN

(Staphylococcus
saprophyticus) 		PF08327
(AHSA1) 		4 SER A  33
ARG A  47
PRO A  23
TRP A  38
 None
 1.18A 4uhxA-3q6aA:
undetectable		 4uhxA-3q6aA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcz DNA REPAIR PROTEIN
RAD60

(Schizosaccharomyces
pombe) 		PF11976
(Rad60-SLD) 		4 GLU A 344
ASP A 345
SER A 340
ARG A 339
 None
 1.13A 4uhxA-3rczA:
3.1		 4uhxA-3rczA:
4.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ASP C 571
SER C1051
PRO C1057
TRP C1113
 None
 1.00A 4uhxA-3sr6C:
45.3		 4uhxA-3sr6C:
30.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ASP C 571
SER C1051
PRO C1057
TRP C1116
 None
 0.56A 4uhxA-3sr6C:
45.3		 4uhxA-3sr6C:
30.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 GLU A 148
ASP A 150
ARG A 143
PRO A 321
 None
 1.22A 4uhxA-3sxfA:
undetectable		 4uhxA-3sxfA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7v METHYLORNITHINE
SYNTHASE PYLB

(Methanosarcina
barkeri) 		PF04055
(Radical_SAM) 		4 GLU A 117
ASP A 118
ARG A  90
PRO A 147
 None
 1.14A 4uhxA-3t7vA:
undetectable		 4uhxA-3t7vA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tma METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01170
(UPF0020)
PF02926
(THUMP) 		4 ASP A 255
SER A 210
ARG A 187
PRO A 184
 None
 1.09A 4uhxA-3tmaA:
undetectable		 4uhxA-3tmaA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		4 HIS A 205
SER A 212
ARG A 152
TRP A 231
 None
 1.01A 4uhxA-3tqsA:
1.6		 4uhxA-3tqsA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Sphingomonas
wittichii) 		PF00903
(Glyoxalase) 		4 GLU A 178
ASP A 180
ARG A 173
PRO A 282
 None
 1.18A 4uhxA-3vb0A:
undetectable		 4uhxA-3vb0A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 ASP A 151
ARG A  94
TRP A  66
TRP A 319
 None
 1.21A 4uhxA-3vszA:
undetectable		 4uhxA-3vszA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 GLU A 578
ASP A 534
ARG A 230
PRO A 539
 None
 1.22A 4uhxA-3vtrA:
undetectable		 4uhxA-3vtrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 HIS A 230
GLU A 349
ARG A 220
PRO A 337
 None
 1.19A 4uhxA-3w4rA:
undetectable		 4uhxA-3w4rA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 GLU A 101
SER A  89
ARG A  46
TRP A  29
 None
 1.15A 4uhxA-3w5nA:
undetectable		 4uhxA-3w5nA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 HIS A 230
GLU A 349
ARG A 220
PRO A 337
 None
 1.19A 4uhxA-3wl1A:
undetectable		 4uhxA-3wl1A:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A 578
SER A1056
ARG A1057
PRO A1062
TRP A1121
 None
 0.53A 4uhxA-3zyvA:
42.5		 4uhxA-3zyvA:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A 578
SER A1056
PRO A1062
TRP A1118
TRP A1121
 None
 1.12A 4uhxA-3zyvA:
42.5		 4uhxA-3zyvA:
61.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 HIS A 354
SER A 454
TRP A 477
TRP A 480
 None
 1.16A 4uhxA-4fusA:
undetectable		 4uhxA-4fusA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk1 TUBEROUS SCLEROSIS 1
PROTEIN HOMOLOG

(Schizosaccharomyces
pombe) 		PF04388
(Hamartin) 		4 HIS A 301
ASP A 241
ARG A 204
PRO A 244
 None
 1.22A 4uhxA-4kk1A:
undetectable		 4uhxA-4kk1A:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdv ANNEXIN

(Schistosoma
mansoni) 		PF00191
(Annexin) 		4 GLU A  43
ASP A  41
SER A  37
ARG A  66
 None
 1.23A 4uhxA-4mdvA:
undetectable		 4uhxA-4mdvA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		4 GLU A 158
ASP A 157
SER A 216
PRO A 214
 None
MN  A 601 ( 2.5A)
None
None
 0.86A 4uhxA-4nhyA:
undetectable		 4uhxA-4nhyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzj PUTATIVE
ALPHA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF05345
(He_PIG)
PF10632
(He_PIG_assoc)
PF16499
(Melibiase_2) 		4 HIS A 317
ASP A 301
PRO A 341
TRP A 285
 None
 1.09A 4uhxA-4nzjA:
undetectable		 4uhxA-4nzjA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		4 GLU A 163
ASP A 162
ARG A 189
TRP A 120
 None
 1.22A 4uhxA-4oe1A:
undetectable		 4uhxA-4oe1A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 ASP A 354
SER A 351
ARG A 288
TRP A 301
 None
 1.06A 4uhxA-4ouaA:
undetectable		 4uhxA-4ouaA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ASP A  65
PRO A  73
TRP A  74
TRP A 208
 None
 1.20A 4uhxA-4pfwA:
undetectable		 4uhxA-4pfwA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		4 GLU A 211
ASP A 210
ARG A  54
TRP A  60
 None
 1.12A 4uhxA-4rzzA:
undetectable		 4uhxA-4rzzA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3a ENDOGLUCANASE H

(Ruminiclostridium
thermocellum) 		PF00150
(Cellulase) 		4 ASP A 297
SER A 301
ARG A 340
TRP A 302
 None
 0.86A 4uhxA-4u3aA:
undetectable		 4uhxA-4u3aA:
14.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A 571
SER A1051
ARG A1052
PRO A1057
TRP A1116
 None
 0.69A 4uhxA-4yswA:
42.2		 4uhxA-4yswA:
49.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASP A 571
SER A1051
PRO A1057
TRP A1113
TRP A1116
 None
 1.10A 4uhxA-4yswA:
42.2		 4uhxA-4yswA:
49.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLU A 570
ASP A 571
SER A1051
ARG A1052
 None
 1.18A 4uhxA-4yswA:
42.2		 4uhxA-4yswA:
49.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		4 HIS A  55
ASP A  58
ARG A 104
TRP A 315
 None
 1.20A 4uhxA-4yztA:
undetectable		 4uhxA-4yztA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzw AGAP004976-PA

(Anopheles
gambiae) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLU A 102
ASP A 315
ARG A 312
TRP A 327
 None
 1.07A 4uhxA-4yzwA:
1.6		 4uhxA-4yzwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrv MINCLE CRD

(Bos taurus) 		PF00059
(Lectin_C) 		4 ASP A 165
SER A 184
ARG A 182
PRO A 187
 None
None
4RS  A 301 (-3.3A)
None
 1.07A 4uhxA-4zrvA:
undetectable		 4uhxA-4zrvA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		4 ASP A  96
SER A 276
ARG A 279
PRO A 322
 None
 1.22A 4uhxA-4zz7A:
undetectable		 4uhxA-4zz7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ap9 LIPASE

(Thermomyces
lanuginosus) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		4 HIS A 215
ASP A 242
ARG A 179
PRO A 208
 None
 1.18A 4uhxA-5ap9A:
undetectable		 4uhxA-5ap9A:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		4 GLU C  25
ASP C 224
ARG C 199
PRO C  26
 None
 1.22A 4uhxA-5b57C:
undetectable		 4uhxA-5b57C:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2

(Mus musculus) 		PF06046
(Sec6) 		4 GLU A 158
ASP A 159
ARG A  96
TRP A 179
 None
 1.12A 4uhxA-5b86A:
undetectable		 4uhxA-5b86A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		4 HIS A 490
ASP A 491
ARG A 516
PRO A 497
 None
None
SO4  A 702 (-3.1A)
None
 1.21A 4uhxA-5bp8A:
undetectable		 4uhxA-5bp8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		4 GLU A 449
SER A 488
ARG A 409
PRO A 485
 None
 1.00A 4uhxA-5dqfA:
undetectable		 4uhxA-5dqfA:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 GLU A 577
ASP A 578
SER A1060
ARG A1061
PRO A1066
TRP A1122
 None
 1.39A 4uhxA-5epgA:
48.0		 4uhxA-5epgA:
99.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		7 HIS A 575
ASP A 578
SER A1060
ARG A1061
PRO A1066
TRP A1122
TRP A1125
 None
 0.92A 4uhxA-5epgA:
48.0		 4uhxA-5epgA:
99.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey6 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF2

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 HIS A 172
GLU A 106
SER A 114
PRO A 112
 None
 0.95A 4uhxA-5ey6A:
undetectable		 4uhxA-5ey6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 HIS A 169
GLU A 103
SER A 112
PRO A 109
 None
 1.19A 4uhxA-5f05A:
undetectable		 4uhxA-5f05A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 GLU A 974
ASP A1021
SER A1023
ARG A1022
 None
 1.12A 4uhxA-5fkuA:
undetectable		 4uhxA-5fkuA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuz 645 FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP H 109
ARG H  97
PRO H 106
TRP H  47
 None
 1.17A 4uhxA-5fuzH:
undetectable		 4uhxA-5fuzH:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3p FORMAMIDASE

(Bacillus cereus) 		PF00795
(CN_hydrolase) 		4 GLU A  75
ASP A  31
TRP A  71
TRP A 142
 None
 1.20A 4uhxA-5g3pA:
undetectable		 4uhxA-5g3pA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		4 GLU A 450
SER A 489
ARG A 410
PRO A 486
 None
 1.15A 4uhxA-5ghkA:
undetectable		 4uhxA-5ghkA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 GLU A 421
ASP A  96
SER A 448
PRO A 452
 MN  A 501 (-2.0A)
None
None
None
 0.81A 4uhxA-5hucA:
undetectable		 4uhxA-5hucA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2b PEPTIDE DEFORMYLASE

(Burkholderia
ambifaria) 		PF01327
(Pep_deformylase) 		4 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 ZN  A 201 ( 3.5A)
BB2  A 202 (-2.2A)
EDO  A 203 ( 4.8A)
EDO  A 203 (-2.8A)
 1.17A 4uhxA-5i2bA:
undetectable		 4uhxA-5i2bA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 GLU A 479
ASP A 505
SER A 459
TRP A 424
 None
None
MG  A 715 (-3.0A)
None
 1.07A 4uhxA-5ixqA:
undetectable		 4uhxA-5ixqA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kob PEPTIDE DEFORMYLASE

(Paraburkholderia
xenovorans) 		PF01327
(Pep_deformylase) 		4 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 FE2  A 201 (-3.4A)
FE2  A 201 ( 4.2A)
FMT  A 204 (-3.7A)
None
 1.16A 4uhxA-5kobA:
undetectable		 4uhxA-5kobA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzt PEPTIDE/NICKEL
TRANSPORT SYSTEM
SUBSTRATE-BINDING
PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		4 ASP A 113
ARG A 111
PRO A 121
TRP A 116
 None
 1.05A 4uhxA-5kztA:
undetectable		 4uhxA-5kztA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		4 GLU A 598
ASP A 600
ARG A 476
PRO A 594
 None
 0.92A 4uhxA-5l9wA:
undetectable		 4uhxA-5l9wA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n0c TETANUS TOXIN

(Clostridium
tetani) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		4 GLU A 819
ASP A 821
SER A 824
ARG A 711
 None
 1.19A 4uhxA-5n0cA:
2.5		 4uhxA-5n0cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 CAPSID VERTEX
PROTEIN GP24

(Escherichia
virus T4) 		PF07068
(Gp23) 		4 GLU a 199
ASP a 200
ARG a  29
PRO a 195
 None
 1.14A 4uhxA-5vf3a:
undetectable		 4uhxA-5vf3a:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqm PA41 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 4 ASP H 107
SER H  99
ARG H  98
PRO H 104
 None
 0.92A 4uhxA-5vqmH:
undetectable		 4uhxA-5vqmH:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE

(Hydra vulgaris) 		no annotation 4 HIS A 414
ASP A 413
SER A 345
ARG A 344
 None
 1.23A 4uhxA-5xomA:
undetectable		 4uhxA-5xomA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3b DIXIN

(Mus musculus) 		PF00778
(DIX) 		4 HIS A 431
GLU A 469
ASP A 470
TRP A 466
 None
 1.16A 4uhxA-5y3bA:
3.5		 4uhxA-5y3bA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yht HISTIDINOL-PHOSPHATA
SE

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A  17
SER A 100
PRO A  84
TRP A  80
 None
 1.17A 4uhxA-5yhtA:
undetectable		 4uhxA-5yhtA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap6 PROBABLE
STRIGOLACTONE
ESTERASE DAD2

(Petunia x
hybrida) 		no annotation 4 HIS A 132
SER A 122
ARG A 199
TRP A 240
 None
 0.93A 4uhxA-6ap6A:
undetectable		 4uhxA-6ap6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)

(Homo sapiens) 		no annotation 4 HIS A1702
GLU A1699
ASP A1698
PRO A1891
 None
 1.12A 4uhxA-6bq1A:
undetectable		 4uhxA-6bq1A:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 4 HIS A 730
ASP A1203
ARG A 676
PRO A 733
 None
 1.18A 4uhxA-6en4A:
undetectable		 4uhxA-6en4A:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6es9 ACYL-COA
DEHYDROGENASE

(Paracoccus
denitrificans) 		no annotation 4 HIS A 191
GLU A 518
SER A 522
ARG A 523
 None
 1.15A 4uhxA-6es9A:
undetectable		 4uhxA-6es9A:
4.93