SIMILAR PATTERNS OF AMINO ACIDS FOR 4UH3_A_H4BA760_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4k | PROTEIN (ORNITHINEDECARBOXYLASE) (Lactobacillussp. 30A) |
PF01276(OKR_DC_1)PF03709(OKR_DC_1_N)PF03711(OKR_DC_1_C) | 4 | VAL A 667TRP A 673PHE A 681GLU A 649 | None | 1.35A | 4uh3A-1c4kA:0.04uh3B-1c4kA:0.0 | 4uh3A-1c4kA:19.074uh3B-1c4kA:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fhu | O-SUCCINYLBENZOATESYNTHASE (Escherichiacoli) |
PF13378(MR_MLE_C) | 4 | ARG A 2VAL A 87TRP A 66GLU A 76 | None | 1.50A | 4uh3A-1fhuA:0.54uh3B-1fhuA:0.5 | 4uh3A-1fhuA:25.234uh3B-1fhuA:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kex | NEUROPILIN-1 (Homo sapiens) |
PF00754(F5_F8_type_C) | 4 | ARG A 130TRP A 97PHE A 131GLU A 95 | None | 1.42A | 4uh3A-1kexA:0.04uh3B-1kexA:0.0 | 4uh3A-1kexA:16.834uh3B-1kexA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kh2 | ARGININOSUCCINATESYNTHETASE (Thermusthermophilus) |
PF00764(Arginosuc_synth) | 4 | ARG A 282VAL A 226PHE A 220GLU A 222 | None | 1.34A | 4uh3A-1kh2A:0.14uh3B-1kh2A:0.5 | 4uh3A-1kh2A:22.654uh3B-1kh2A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | ARG A 340TRP A 155PHE A 156GLU A 154 | None | 1.33A | 4uh3A-1l5jA:0.04uh3B-1l5jA:0.0 | 4uh3A-1l5jA:19.284uh3B-1l5jA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mzb | FERRIC UPTAKEREGULATION PROTEIN (Pseudomonasaeruginosa) |
PF01475(FUR) | 4 | ARG A 69VAL A 54PHE A 79GLU A 36 | None | 1.00A | 4uh3A-1mzbA:0.64uh3B-1mzbA:0.3 | 4uh3A-1mzbA:16.594uh3B-1mzbA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t1j | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF09152(DUF1937) | 4 | ARG A 2VAL A 28TRP A 110PHE A 117 | None | 1.44A | 4uh3A-1t1jA:0.04uh3B-1t1jA:0.0 | 4uh3A-1t1jA:16.384uh3B-1t1jA:16.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vmk | PURINE NUCLEOSIDEPHOSPHORYLASE (Thermotogamaritima) |
PF01048(PNP_UDP_1) | 4 | VAL A 221TRP A 162PHE A 265GLU A 161 | None | 1.43A | 4uh3A-1vmkA:0.04uh3B-1vmkA:0.0 | 4uh3A-1vmkA:21.484uh3B-1vmkA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wql | ETHYLBENZENEDIOXYGENASE SMALLSUBUNIT (Pseudomonasfluorescens) |
PF00866(Ring_hydroxyl_B) | 4 | ARG B 156VAL B 128PHE B 163GLU B 26 | None | 1.12A | 4uh3A-1wqlB:0.04uh3B-1wqlB:0.0 | 4uh3A-1wqlB:19.794uh3B-1wqlB:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | ARG A 708VAL A1424PHE A 722GLU A 693 | None | 1.10A | 4uh3A-2b39A:undetectable4uh3B-2b39A:undetectable | 4uh3A-2b39A:13.584uh3B-2b39A:13.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT AADENYLYLSULFATEREDUCTASE, SUBUNIT B (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | ARG A 62VAL A 367TRP B 788GLU A 360 | None | 1.39A | 4uh3A-2fjaA:0.64uh3B-2fjaA:undetectable | 4uh3A-2fjaA:22.294uh3B-2fjaA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9u | CYTOSINE/GUANINEDEAMINASE RELATEDPROTEIN (Clostridiumacetobutylicum) |
PF01979(Amidohydro_1) | 4 | ARG A 202TRP A 93PHE A 99GLU A 101 | GUN A 503 (-3.7A)NoneNoneNone | 1.32A | 4uh3A-2i9uA:undetectable4uh3B-2i9uA:undetectable | 4uh3A-2i9uA:20.974uh3B-2i9uA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vy0 | ENDO-BETA-1,3-GLUCANASE (Pyrococcusfuriosus) |
PF00722(Glyco_hydro_16) | 4 | VAL A 245TRP A 252PHE A 254GLU A 251 | NoneNoneNoneMRD A1301 (-4.3A) | 1.43A | 4uh3A-2vy0A:undetectable4uh3B-2vy0A:undetectable | 4uh3A-2vy0A:20.004uh3B-2vy0A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4o | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE IV (Homo sapiens) |
PF00069(Pkinase) | 4 | ARG A 278VAL A 269TRP A 266PHE A 261 | None | 1.46A | 4uh3A-2w4oA:undetectable4uh3B-2w4oA:undetectable | 4uh3A-2w4oA:20.264uh3B-2w4oA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 4 | ARG A 697VAL A 717PHE A 698GLU A 722 | None | 1.30A | 4uh3A-2xvgA:0.54uh3B-2xvgA:0.5 | 4uh3A-2xvgA:19.684uh3B-2xvgA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 4 | ARG A 211VAL A 239PHE A 309GLU A 305 | None | 1.34A | 4uh3A-2ywbA:undetectable4uh3B-2ywbA:undetectable | 4uh3A-2ywbA:21.544uh3B-2ywbA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z11 | RIBOSOMAL-PROTEIN-ALANINEACETYLTRANSFERASE (Thermusthermophilus) |
PF13302(Acetyltransf_3) | 4 | VAL A 64TRP A 66PHE A 4GLU A 6 | None | 1.45A | 4uh3A-2z11A:undetectable4uh3B-2z11A:undetectable | 4uh3A-2z11A:17.584uh3B-2z11A:17.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zpk | IGG1-LAMBDA P20.1FAB (HEAVY CHAIN) (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | VAL H 37TRP H 47PHE H 69GLU H 95 | None | 1.31A | 4uh3A-2zpkH:undetectable4uh3B-2zpkH:undetectable | 4uh3A-2zpkH:20.104uh3B-2zpkH:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b7f | GLYCOSYL HYDROLASE,BNR REPEAT (Cupriaviduspinatubonensis) |
no annotation | 4 | VAL A 314TRP A 293TRP A 374GLU A 372 | NoneNoneNoneEDO A 404 ( 3.8A) | 1.40A | 4uh3A-3b7fA:undetectable4uh3B-3b7fA:undetectable | 4uh3A-3b7fA:20.874uh3B-3b7fA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddl | XANTHORHODOPSIN (Salinibacterruber) |
PF01036(Bac_rhodopsin) | 4 | VAL A 16TRP A 70PHE A 88GLU A 71 | None | 1.49A | 4uh3A-3ddlA:1.14uh3B-3ddlA:undetectable | 4uh3A-3ddlA:20.144uh3B-3ddlA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gs3 | SYMPLEKIN (Drosophilamelanogaster) |
PF11935(DUF3453) | 4 | ARG A 27VAL A 56PHE A 67GLU A 65 | None | 1.49A | 4uh3A-3gs3A:undetectable4uh3B-3gs3A:undetectable | 4uh3A-3gs3A:20.284uh3B-3gs3A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyx | ADENYLYLSULFATEREDUCTASE (Desulfovibriogigas) |
PF00890(FAD_binding_2)PF12139(APS-reductase_C)PF13187(Fer4_9) | 4 | ARG A 66VAL A 387TRP B 88GLU A 380 | None | 1.33A | 4uh3A-3gyxA:undetectable4uh3B-3gyxA:0.0 | 4uh3A-3gyxA:20.984uh3B-3gyxA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ma6 | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase) | 4 | ARG A 269VAL A 260TRP A 257PHE A 252 | None | 1.45A | 4uh3A-3ma6A:undetectable4uh3B-3ma6A:undetectable | 4uh3A-3ma6A:21.554uh3B-3ma6A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ojd | FAB V2D2 (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | VAL B 37TRP B 47PHE B 69GLU B 95 | None | 1.43A | 4uh3A-3ojdB:undetectable4uh3B-3ojdB:undetectable | 4uh3A-3ojdB:20.004uh3B-3ojdB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3owc | PROBABLEACETYLTRANSFERASE (Pseudomonasaeruginosa) |
PF00583(Acetyltransf_1) | 4 | ARG A 175VAL A 92PHE A 121GLU A 119 | None | 1.26A | 4uh3A-3owcA:1.74uh3B-3owcA:1.7 | 4uh3A-3owcA:16.474uh3B-3owcA:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjy | ENDOGLUCANASEFNCEL5A (Fervidobacteriumnodosum) |
PF00150(Cellulase) | 4 | VAL A 149TRP A 146PHE A 162GLU A 187 | None | 1.28A | 4uh3A-3rjyA:1.34uh3B-3rjyA:1.4 | 4uh3A-3rjyA:21.274uh3B-3rjyA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqu | NON-CANONICAL PURINENTP PYROPHOSPHATASE (Coxiellaburnetii) |
PF01725(Ham1p_like) | 4 | VAL A 162TRP A 140PHE A 118GLU A 141 | None | 1.27A | 4uh3A-3tquA:undetectable4uh3B-3tquA:undetectable | 4uh3A-3tquA:19.054uh3B-3tquA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uxm | THYMIDYLATE KINASE (Pseudomonasaeruginosa) |
PF02223(Thymidylate_kin) | 4 | ARG A 109VAL A 166PHE A 162GLU A 156 | NoneNoneNone MG A 213 (-3.2A) | 1.32A | 4uh3A-3uxmA:undetectable4uh3B-3uxmA:undetectable | 4uh3A-3uxmA:20.294uh3B-3uxmA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bgd | PRE-MRNA-SPLICINGFACTOR 8 (Saccharomycescerevisiae) |
PF08084(PROCT) | 4 | VAL C2274TRP C2314PHE C2329GLU C2310 | None | 1.34A | 4uh3A-4bgdC:undetectable4uh3B-4bgdC:undetectable | 4uh3A-4bgdC:20.994uh3B-4bgdC:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 4 | ARG A 373VAL A 412TRP A 383PHE A 370 | None | 1.47A | 4uh3A-4fnqA:undetectable4uh3B-4fnqA:undetectable | 4uh3A-4fnqA:20.734uh3B-4fnqA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l37 | ARYLPHORIN (Bombyx mori) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 4 | VAL B 351TRP B 355PHE B 327GLU B 424 | None | 1.03A | 4uh3A-4l37B:undetectable4uh3B-4l37B:undetectable | 4uh3A-4l37B:20.694uh3B-4l37B:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pne | METHYLTRANSFERASE-LIKE PROTEIN (Saccharopolysporaspinosa) |
PF08241(Methyltransf_11) | 4 | ARG A 75VAL A 79PHE A 141GLU A 162 | None | 1.35A | 4uh3A-4pneA:undetectable4uh3B-4pneA:undetectable | 4uh3A-4pneA:21.364uh3B-4pneA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | ARG A 276VAL A 305PHE A 264GLU A 266 | None | 1.13A | 4uh3A-4xj6A:undetectable4uh3B-4xj6A:1.6 | 4uh3A-4xj6A:21.064uh3B-4xj6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj6 | VC0179-LIKE PROTEIN (Escherichiacoli) |
no annotation | 4 | VAL A 305TRP A 263PHE A 264GLU A 266 | None | 1.12A | 4uh3A-4xj6A:undetectable4uh3B-4xj6A:1.6 | 4uh3A-4xj6A:21.064uh3B-4xj6A:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by3 | BTGH115A (Bacteroidesthetaiotaomicron) |
PF15979(Glyco_hydro_115) | 4 | ARG A 505VAL A 736TRP A 732GLU A 731 | None | 1.37A | 4uh3A-5by3A:undetectable4uh3B-5by3A:undetectable | 4uh3A-5by3A:19.824uh3B-5by3A:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fjn | L-AMINO ACIDDEAMINASE (Cosenzaeamyxofaciens) |
PF01266(DAO) | 4 | ARG A 316VAL A 438TRP A 439GLU A 418 | BE2 A1476 (-4.0A)BE2 A1476 ( 4.3A)BE2 A1476 ( 3.7A)None | 1.33A | 4uh3A-5fjnA:undetectable4uh3B-5fjnA:undetectable | 4uh3A-5fjnA:23.274uh3B-5fjnA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kn8 | ADENINE DNAGLYCOSYLASE (Geobacillusstearothermophilus) |
PF00633(HHH)PF00730(HhH-GPD) | 4 | VAL A 92TRP A 83PHE A 61GLU A 84 | None | 1.37A | 4uh3A-5kn8A:undetectable4uh3B-5kn8A:undetectable | 4uh3A-5kn8A:22.284uh3B-5kn8A:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8t | 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACIDOXIDASE (Homo sapiens) |
PF00264(Tyrosinase) | 4 | ARG A 225TRP A 414PHE A 411GLU A 413 | None | 1.10A | 4uh3A-5m8tA:undetectable4uh3B-5m8tA:0.0 | 4uh3A-5m8tA:20.004uh3B-5m8tA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xct | VH(S112C)-SARAHCHIMERA (Homo sapiens;Mus musculus) |
PF07686(V-set)PF11629(Mst1_SARAH) | 4 | VAL A 37TRP A 47PHE A 69GLU A 95 | None | 1.31A | 4uh3A-5xctA:undetectable4uh3B-5xctA:undetectable | 4uh3A-5xctA:16.714uh3B-5xctA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xf7 | PROTEINDISULFIDE-ISOMERASE-LIKE PROTEIN OF THETESTIS (Homo sapiens) |
no annotation | 4 | ARG A 129VAL A 65PHE A 113GLU A 106 | None | 1.22A | 4uh3A-5xf7A:undetectable4uh3B-5xf7A:undetectable | 4uh3A-5xf7A:10.854uh3B-5xf7A:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bk1 | UDP-GLYCOSYLTRANSFERASE 79 (Oryza sativa) |
no annotation | 4 | ARG A 331VAL A 317TRP A 316GLU A 322 | NoneUDP A 501 ( 4.8A)NoneNone | 1.28A | 4uh3A-6bk1A:0.14uh3B-6bk1A:0.0 | 4uh3A-6bk1A:13.484uh3B-6bk1A:13.48 |