SIMILAR PATTERNS OF AMINO ACIDS FOR 4UH3_A_H4BA760_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)


(Lactobacillus
sp. 30A)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
4 VAL A 667
TRP A 673
PHE A 681
GLU A 649
None
1.35A 4uh3A-1c4kA:
0.0
4uh3B-1c4kA:
0.0
4uh3A-1c4kA:
19.07
4uh3B-1c4kA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE


(Escherichia
coli)
PF13378
(MR_MLE_C)
4 ARG A   2
VAL A  87
TRP A  66
GLU A  76
None
1.50A 4uh3A-1fhuA:
0.5
4uh3B-1fhuA:
0.5
4uh3A-1fhuA:
25.23
4uh3B-1fhuA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens)
PF00754
(F5_F8_type_C)
4 ARG A 130
TRP A  97
PHE A 131
GLU A  95
None
1.42A 4uh3A-1kexA:
0.0
4uh3B-1kexA:
0.0
4uh3A-1kexA:
16.83
4uh3B-1kexA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
4 ARG A 282
VAL A 226
PHE A 220
GLU A 222
None
1.34A 4uh3A-1kh2A:
0.1
4uh3B-1kh2A:
0.5
4uh3A-1kh2A:
22.65
4uh3B-1kh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2


(Escherichia
coli)
PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N)
4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
None
1.33A 4uh3A-1l5jA:
0.0
4uh3B-1l5jA:
0.0
4uh3A-1l5jA:
19.28
4uh3B-1l5jA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN


(Pseudomonas
aeruginosa)
PF01475
(FUR)
4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
None
1.00A 4uh3A-1mzbA:
0.6
4uh3B-1mzbA:
0.3
4uh3A-1mzbA:
16.59
4uh3B-1mzbA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF09152
(DUF1937)
4 ARG A   2
VAL A  28
TRP A 110
PHE A 117
None
1.44A 4uh3A-1t1jA:
0.0
4uh3B-1t1jA:
0.0
4uh3A-1t1jA:
16.38
4uh3B-1t1jA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE


(Thermotoga
maritima)
PF01048
(PNP_UDP_1)
4 VAL A 221
TRP A 162
PHE A 265
GLU A 161
None
1.43A 4uh3A-1vmkA:
0.0
4uh3B-1vmkA:
0.0
4uh3A-1vmkA:
21.48
4uh3B-1vmkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT


(Pseudomonas
fluorescens)
PF00866
(Ring_hydroxyl_B)
4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
None
1.12A 4uh3A-1wqlB:
0.0
4uh3B-1wqlB:
0.0
4uh3A-1wqlB:
19.79
4uh3B-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
None
1.10A 4uh3A-2b39A:
undetectable
4uh3B-2b39A:
undetectable
4uh3A-2b39A:
13.58
4uh3B-2b39A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 ARG A  62
VAL A 367
TRP B 788
GLU A 360
None
1.39A 4uh3A-2fjaA:
0.6
4uh3B-2fjaA:
undetectable
4uh3A-2fjaA:
22.29
4uh3B-2fjaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN


(Clostridium
acetobutylicum)
PF01979
(Amidohydro_1)
4 ARG A 202
TRP A  93
PHE A  99
GLU A 101
GUN  A 503 (-3.7A)
None
None
None
1.32A 4uh3A-2i9uA:
undetectable
4uh3B-2i9uA:
undetectable
4uh3A-2i9uA:
20.97
4uh3B-2i9uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE


(Pyrococcus
furiosus)
PF00722
(Glyco_hydro_16)
4 VAL A 245
TRP A 252
PHE A 254
GLU A 251
None
None
None
MRD  A1301 (-4.3A)
1.43A 4uh3A-2vy0A:
undetectable
4uh3B-2vy0A:
undetectable
4uh3A-2vy0A:
20.00
4uh3B-2vy0A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV


(Homo sapiens)
PF00069
(Pkinase)
4 ARG A 278
VAL A 269
TRP A 266
PHE A 261
None
1.46A 4uh3A-2w4oA:
undetectable
4uh3B-2w4oA:
undetectable
4uh3A-2w4oA:
20.26
4uh3B-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 ARG A 697
VAL A 717
PHE A 698
GLU A 722
None
1.30A 4uh3A-2xvgA:
0.5
4uh3B-2xvgA:
0.5
4uh3A-2xvgA:
19.68
4uh3B-2xvgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
4 ARG A 211
VAL A 239
PHE A 309
GLU A 305
None
1.34A 4uh3A-2ywbA:
undetectable
4uh3B-2ywbA:
undetectable
4uh3A-2ywbA:
21.54
4uh3B-2ywbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF13302
(Acetyltransf_3)
4 VAL A  64
TRP A  66
PHE A   4
GLU A   6
None
1.45A 4uh3A-2z11A:
undetectable
4uh3B-2z11A:
undetectable
4uh3A-2z11A:
17.58
4uh3B-2z11A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 VAL H  37
TRP H  47
PHE H  69
GLU H  95
None
1.31A 4uh3A-2zpkH:
undetectable
4uh3B-2zpkH:
undetectable
4uh3A-2zpkH:
20.10
4uh3B-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT


(Cupriavidus
pinatubonensis)
no annotation 4 VAL A 314
TRP A 293
TRP A 374
GLU A 372
None
None
None
EDO  A 404 ( 3.8A)
1.40A 4uh3A-3b7fA:
undetectable
4uh3B-3b7fA:
undetectable
4uh3A-3b7fA:
20.87
4uh3B-3b7fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber)
PF01036
(Bac_rhodopsin)
4 VAL A  16
TRP A  70
PHE A  88
GLU A  71
None
1.49A 4uh3A-3ddlA:
1.1
4uh3B-3ddlA:
undetectable
4uh3A-3ddlA:
20.14
4uh3B-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster)
PF11935
(DUF3453)
4 ARG A  27
VAL A  56
PHE A  67
GLU A  65
None
1.49A 4uh3A-3gs3A:
undetectable
4uh3B-3gs3A:
undetectable
4uh3A-3gs3A:
20.28
4uh3B-3gs3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE


(Desulfovibrio
gigas)
PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 ARG A  66
VAL A 387
TRP B  88
GLU A 380
None
1.33A 4uh3A-3gyxA:
undetectable
4uh3B-3gyxA:
0.0
4uh3A-3gyxA:
20.98
4uh3B-3gyxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
4 ARG A 269
VAL A 260
TRP A 257
PHE A 252
None
1.45A 4uh3A-3ma6A:
undetectable
4uh3B-3ma6A:
undetectable
4uh3A-3ma6A:
21.55
4uh3B-3ma6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojd FAB V2D2

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 VAL B  37
TRP B  47
PHE B  69
GLU B  95
None
1.43A 4uh3A-3ojdB:
undetectable
4uh3B-3ojdB:
undetectable
4uh3A-3ojdB:
20.00
4uh3B-3ojdB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
None
1.26A 4uh3A-3owcA:
1.7
4uh3B-3owcA:
1.7
4uh3A-3owcA:
16.47
4uh3B-3owcA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A


(Fervidobacterium
nodosum)
PF00150
(Cellulase)
4 VAL A 149
TRP A 146
PHE A 162
GLU A 187
None
1.28A 4uh3A-3rjyA:
1.3
4uh3B-3rjyA:
1.4
4uh3A-3rjyA:
21.27
4uh3B-3rjyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE


(Coxiella
burnetii)
PF01725
(Ham1p_like)
4 VAL A 162
TRP A 140
PHE A 118
GLU A 141
None
1.27A 4uh3A-3tquA:
undetectable
4uh3B-3tquA:
undetectable
4uh3A-3tquA:
19.05
4uh3B-3tquA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa)
PF02223
(Thymidylate_kin)
4 ARG A 109
VAL A 166
PHE A 162
GLU A 156
None
None
None
MG  A 213 (-3.2A)
1.32A 4uh3A-3uxmA:
undetectable
4uh3B-3uxmA:
undetectable
4uh3A-3uxmA:
20.29
4uh3B-3uxmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8


(Saccharomyces
cerevisiae)
PF08084
(PROCT)
4 VAL C2274
TRP C2314
PHE C2329
GLU C2310
None
1.34A 4uh3A-4bgdC:
undetectable
4uh3B-4bgdC:
undetectable
4uh3A-4bgdC:
20.99
4uh3B-4bgdC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 ARG A 373
VAL A 412
TRP A 383
PHE A 370
None
1.47A 4uh3A-4fnqA:
undetectable
4uh3B-4fnqA:
undetectable
4uh3A-4fnqA:
20.73
4uh3B-4fnqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 VAL B 351
TRP B 355
PHE B 327
GLU B 424
None
1.03A 4uh3A-4l37B:
undetectable
4uh3B-4l37B:
undetectable
4uh3A-4l37B:
20.69
4uh3B-4l37B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN


(Saccharopolyspora
spinosa)
PF08241
(Methyltransf_11)
4 ARG A  75
VAL A  79
PHE A 141
GLU A 162
None
1.35A 4uh3A-4pneA:
undetectable
4uh3B-4pneA:
undetectable
4uh3A-4pneA:
21.36
4uh3B-4pneA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
None
1.13A 4uh3A-4xj6A:
undetectable
4uh3B-4xj6A:
1.6
4uh3A-4xj6A:
21.06
4uh3B-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
None
1.12A 4uh3A-4xj6A:
undetectable
4uh3B-4xj6A:
1.6
4uh3A-4xj6A:
21.06
4uh3B-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron)
PF15979
(Glyco_hydro_115)
4 ARG A 505
VAL A 736
TRP A 732
GLU A 731
None
1.37A 4uh3A-5by3A:
undetectable
4uh3B-5by3A:
undetectable
4uh3A-5by3A:
19.82
4uh3B-5by3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE


(Cosenzaea
myxofaciens)
PF01266
(DAO)
4 ARG A 316
VAL A 438
TRP A 439
GLU A 418
BE2  A1476 (-4.0A)
BE2  A1476 ( 4.3A)
BE2  A1476 ( 3.7A)
None
1.33A 4uh3A-5fjnA:
undetectable
4uh3B-5fjnA:
undetectable
4uh3A-5fjnA:
23.27
4uh3B-5fjnA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE


(Geobacillus
stearothermophilus)
PF00633
(HHH)
PF00730
(HhH-GPD)
4 VAL A  92
TRP A  83
PHE A  61
GLU A  84
None
1.37A 4uh3A-5kn8A:
undetectable
4uh3B-5kn8A:
undetectable
4uh3A-5kn8A:
22.28
4uh3B-5kn8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
None
1.10A 4uh3A-5m8tA:
undetectable
4uh3B-5m8tA:
0.0
4uh3A-5m8tA:
20.00
4uh3B-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VH(S112C)-SARAH
CHIMERA


(Homo sapiens;
Mus musculus)
PF07686
(V-set)
PF11629
(Mst1_SARAH)
4 VAL A  37
TRP A  47
PHE A  69
GLU A  95
None
1.31A 4uh3A-5xctA:
undetectable
4uh3B-5xctA:
undetectable
4uh3A-5xctA:
16.71
4uh3B-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS


(Homo sapiens)
no annotation 4 ARG A 129
VAL A  65
PHE A 113
GLU A 106
None
1.22A 4uh3A-5xf7A:
undetectable
4uh3B-5xf7A:
undetectable
4uh3A-5xf7A:
10.85
4uh3B-5xf7A:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79


(Oryza sativa)
no annotation 4 ARG A 331
VAL A 317
TRP A 316
GLU A 322
None
UDP  A 501 ( 4.8A)
None
None
1.28A 4uh3A-6bk1A:
0.1
4uh3B-6bk1A:
0.0
4uh3A-6bk1A:
13.48
4uh3B-6bk1A:
13.48