SIMILAR PATTERNS OF AMINO ACIDS FOR 4UDC_A_DEXA1778_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9h PROTEIN
(3-AMINO-5-HYDROXYBE
NZOIC ACID SYNTHASE)

(Amycolatopsis
mediterranei) 		PF01041
(DegT_DnrJ_EryC1) 		3 MET A 142
GLN A 279
TYR A 112
 None
 0.95A 4udcA-1b9hA:
0.0		 4udcA-1b9hA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cia CHLORAMPHENICOL
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00302
(CAT) 		3 MET A 118
GLN A 137
TYR A 128
 None
 0.90A 4udcA-1ciaA:
0.0		 4udcA-1ciaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		3 MET A 306
GLN A 361
TYR A  75
 None
None
DCA  A 801 (-3.9A)
 1.08A 4udcA-1e1cA:
0.0		 4udcA-1e1cA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR

(Homo sapiens) 		PF13374
(TPR_10)
PF13432
(TPR_16) 		3 MET A 370
GLN A 384
TYR A 283
 None
 1.02A 4udcA-1fchA:
0.1		 4udcA-1fchA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 MET A 264
GLN A  64
TYR A 231
 None
MRD  A1104 (-3.5A)
None
 1.11A 4udcA-1hwwA:
undetectable		 4udcA-1hwwA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		3 MET A 214
GLN A 201
TYR A 220
 None
K  A1603 ( 4.7A)
None
 0.80A 4udcA-1iwpA:
0.0		 4udcA-1iwpA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcg ULBP3 PROTEIN

(Homo sapiens) 		PF00129
(MHC_I) 		3 MET C 179
GLN C  60
TYR C  62
 GSH  C 999 (-4.6A)
None
None
 1.07A 4udcA-1kcgC:
1.8		 4udcA-1kcgC:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		3 MET A 344
GLN A 352
TYR A 334
 None
 1.03A 4udcA-1l2qA:
0.0		 4udcA-1l2qA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpc DIANTHIN 30

(Dianthus
caryophyllus) 		PF00161
(RIP) 		3 MET A 174
GLN A  22
TYR A   4
 None
 0.69A 4udcA-1lpcA:
undetectable		 4udcA-1lpcA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh1 COLICIN B

(Escherichia
coli) 		PF01024
(Colicin)
PF03515
(Cloacin) 		3 MET A 261
GLN A 176
TYR A 181
 None
 0.92A 4udcA-1rh1A:
undetectable		 4udcA-1rh1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1shw EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF01404
(Ephrin_lbd) 		3 MET B 244
GLN B 387
TYR B 322
 None
 1.06A 4udcA-1shwB:
undetectable		 4udcA-1shwB:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		3 MET A 213
GLN A 200
TYR A 219
 None
K  A2603 ( 4.8A)
None
 0.74A 4udcA-1uc4A:
undetectable		 4udcA-1uc4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 MET A 187
GLN A 184
TYR A 207
 None
 0.98A 4udcA-1udqA:
undetectable		 4udcA-1udqA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		3 MET A 207
GLN A 266
TYR A 275
 None
 0.89A 4udcA-1yjkA:
undetectable		 4udcA-1yjkA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avx REGULATORY PROTEIN
SDIA

(Escherichia
coli) 		PF03472
(Autoind_bind) 		3 MET A 154
GLN A  35
TYR A  42
 None
 1.05A 4udcA-2avxA:
undetectable		 4udcA-2avxA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4v RNA EDITING COMPLEX
PROTEIN MP57

(Trypanosoma
brucei) 		PF01909
(NTP_transf_2)
PF03828
(PAP_assoc) 		3 MET A  56
GLN A  64
TYR A 352
 None
 0.97A 4udcA-2b4vA:
undetectable		 4udcA-2b4vA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dt7 SPLICING FACTOR 3
SUBUNIT 1

(Homo sapiens) 		PF01805
(Surp) 		3 MET B 186
GLN B 194
TYR B 193
 None
 0.81A 4udcA-2dt7B:
undetectable		 4udcA-2dt7B:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2du3 O-PHOSPHOSERYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01409
(tRNA-synt_2d) 		3 MET A 324
GLN A  82
TYR A 317
 None
 1.09A 4udcA-2du3A:
undetectable		 4udcA-2du3A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		3 MET A  47
GLN A 268
TYR A  69
 None
 1.01A 4udcA-2epgA:
undetectable		 4udcA-2epgA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 MET A 275
GLN A 271
TYR A 269
 None
GOL  A 778 (-3.8A)
None
 0.98A 4udcA-2f3oA:
undetectable		 4udcA-2f3oA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7n DNA-BINDING STRESS
RESPONSE PROTEIN,
DPS FAMILY

(Deinococcus
radiodurans) 		PF00210
(Ferritin) 		3 MET A 196
GLN A 149
TYR A  82
 None
 0.90A 4udcA-2f7nA:
undetectable		 4udcA-2f7nA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5t DIPEPTIDYL PEPTIDASE
4

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 MET A 325
GLN A 320
TYR A 299
 None
 0.72A 4udcA-2g5tA:
undetectable		 4udcA-2g5tA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgn HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN F

(Homo sapiens) 		PF00076
(RRM_1)
PF08080
(zf-RNPHF) 		3 MET A 293
GLN A 353
TYR A 298
 None
 0.97A 4udcA-2hgnA:
undetectable		 4udcA-2hgnA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hsd 3-ALPHA, 20
BETA-HYDROXYSTEROID
DEHYDROGENASE

(Streptomyces
exfoliatus) 		PF13561
(adh_short_C2) 		3 MET A 207
GLN A 197
TYR A 186
 None
 0.81A 4udcA-2hsdA:
undetectable		 4udcA-2hsdA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7g MONOOXYGENASE

(Agrobacterium
fabrum) 		PF00296
(Bac_luciferase) 		3 MET A 324
GLN A 312
TYR A   6
 None
 0.98A 4udcA-2i7gA:
undetectable		 4udcA-2i7gA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ib5 CHROMO PROTEIN

(Epiactis
japonica) 		PF01353
(GFP) 		3 MET A  25
GLN A 106
TYR A 117
 None
CRQ  A  65 ( 4.1A)
CRQ  A  65 ( 4.1A)
 1.00A 4udcA-2ib5A:
undetectable		 4udcA-2ib5A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ig3 GROUP III TRUNCATED
HAEMOGLOBIN

(Campylobacter
jejuni) 		PF01152
(Bac_globin) 		3 MET A 112
GLN A  80
TYR A 122
 None
 0.99A 4udcA-2ig3A:
undetectable		 4udcA-2ig3A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iw0 CHITIN DEACETYLASE

(Colletotrichum
lindemuthianum) 		PF01522
(Polysacc_deac_1) 		3 MET A 141
GLN A 125
TYR A 106
 None
 1.04A 4udcA-2iw0A:
undetectable		 4udcA-2iw0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l03 LY-6/NEUROTOXIN-LIKE
PROTEIN 1

(Homo sapiens) 		PF00087
(Toxin_TOLIP) 		3 MET A  18
GLN A  68
TYR A  26
 None
 1.07A 4udcA-2l03A:
undetectable		 4udcA-2l03A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpc PYRIN

(Homo sapiens) 		PF02758
(PYRIN) 		3 MET A  53
GLN A  34
TYR A  65
 None
 1.06A 4udcA-2mpcA:
undetectable		 4udcA-2mpcA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyz HYPOTHETICAL PROTEIN
GAMMAHV.M3

(Murid
gammaherpesvirus
4) 		PF09213
(M3) 		3 MET A 322
GLN A 372
TYR A 374
 None
 1.02A 4udcA-2nyzA:
undetectable		 4udcA-2nyzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oae DIPEPTIDYL PEPTIDASE
4

(Rattus
norvegicus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 MET A 323
GLN A 318
TYR A 297
 None
 0.69A 4udcA-2oaeA:
undetectable		 4udcA-2oaeA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		3 MET B 316
GLN B  81
TYR B 309
 None
 1.07A 4udcA-2odrB:
undetectable		 4udcA-2odrB:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbx EPHRIN TYPE-B
RECEPTOR 2

(Homo sapiens) 		PF01404
(Ephrin_lbd) 		3 MET A  44
GLN A 187
TYR A 122
 None
 1.07A 4udcA-2qbxA:
undetectable		 4udcA-2qbxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 MET A 402
GLN A 451
TYR A 465
 None
 1.05A 4udcA-2qquA:
undetectable		 4udcA-2qquA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg9 BIFUNCTIONAL
ENDO-1,4-BETA-XYLANA
SE A

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		3 MET A 129
GLN A 141
TYR A 159
 None
 0.98A 4udcA-2vg9A:
undetectable		 4udcA-2vg9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2u HYPOTHETICAL P60
KATANIN

(Sulfolobus
acidocaldarius) 		PF04212
(MIT) 		3 MET A  60
GLN A   4
TYR A  48
 None
 0.96A 4udcA-2w2uA:
undetectable		 4udcA-2w2uA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 MET A 191
GLN A 125
TYR A 131
 None
EDO  A1506 (-4.3A)
EDO  A1506 (-4.3A)
 1.11A 4udcA-2w40A:
undetectable		 4udcA-2w40A:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzr POLYPROTEIN

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		3 MET 3  91
GLN 3 100
TYR 3 170
 None
 1.13A 4udcA-2wzr3:
undetectable		 4udcA-2wzr3:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi7 RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF15518
(L_protein_N) 		3 MET A  31
GLN A 160
TYR A   6
 XI7  A1186 ( 4.3A)
None
None
 1.07A 4udcA-2xi7A:
undetectable		 4udcA-2xi7A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 MET A 408
GLN A 527
TYR A 561
 None
 0.98A 4udcA-2yd0A:
undetectable		 4udcA-2yd0A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zle PROTEASE DO

(Escherichia
coli) 		PF00595
(PDZ)
PF13365
(Trypsin_2) 		3 MET A  90
GLN A 208
TYR A 212
 None
 0.99A 4udcA-2zleA:
undetectable		 4udcA-2zleA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3h ENDOGLUCANASE

(Salipaludibacillus
agaradhaerens) 		PF00150
(Cellulase) 		3 MET A 196
GLN A 220
TYR A 216
 None
 1.05A 4udcA-3a3hA:
undetectable		 4udcA-3a3hA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs6 INNER MEMBRANE
PROTEIN OXAA

(Escherichia
coli) 		PF14849
(YidC_periplas) 		3 MET A 255
GLN A 258
TYR A 259
 None
 0.97A 4udcA-3bs6A:
undetectable		 4udcA-3bs6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY

(Acinetobacter
sp. ADP1) 		no annotation 3 MET A  66
GLN A 107
TYR A 109
 None
 1.04A 4udcA-3d3oA:
undetectable		 4udcA-3d3oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1

(Drosophila
melanogaster) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 MET A 237
GLN A 228
TYR A 414
 None
 1.11A 4udcA-3dh9A:
undetectable		 4udcA-3dh9A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0t PUTATIVE
AMINOTRANSFERASE

(Porphyromonas
gingivalis) 		PF00155
(Aminotran_1_2) 		3 MET A 114
GLN A 266
TYR A 263
 None
 1.02A 4udcA-3g0tA:
undetectable		 4udcA-3g0tA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm5 LACTOYLGLUTATHIONE
LYASE AND RELATED
LYASES

(Caldanaerobacter
subterraneus) 		PF13669
(Glyoxalase_4) 		3 MET A 118
GLN A 122
TYR A 131
 None
None
CIT  A 379 (-3.9A)
 1.09A 4udcA-3gm5A:
undetectable		 4udcA-3gm5A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gt5 N-ACETYLGLUCOSAMINE
2-EPIMERASE

(Xylella
fastidiosa) 		PF07221
(GlcNAc_2-epim) 		3 MET A 185
GLN A 216
TYR A 228
 None
 0.90A 4udcA-3gt5A:
undetectable		 4udcA-3gt5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 MET B 368
GLN B 317
TYR B 362
 None
 0.84A 4udcA-3hhsB:
undetectable		 4udcA-3hhsB:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		3 MET A 171
GLN A  22
TYR A   4
 None
 0.71A 4udcA-3hiqA:
undetectable		 4udcA-3hiqA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		3 MET A 171
GLN A  22
TYR A   4
 None
 0.75A 4udcA-3hiwA:
undetectable		 4udcA-3hiwA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 2

(Thermus
thermophilus) 		PF01257
(2Fe-2S_thioredx) 		3 MET 2  61
GLN 2  35
TYR 2  69
 None
 0.93A 4udcA-3i9v2:
undetectable		 4udcA-3i9v2:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxw SAFRAMYCIN MX1
SYNTHETASE B

(Legionella
pneumophila) 		PF00501
(AMP-binding) 		3 MET A 178
GLN A 532
TYR A  94
 None
 0.88A 4udcA-3kxwA:
undetectable		 4udcA-3kxwA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pw3 AMINOPEPTIDASE C

(Parabacteroides
distasonis) 		PF03051
(Peptidase_C1_2) 		3 MET A 133
GLN A 183
TYR A  86
 None
 1.04A 4udcA-3pw3A:
undetectable		 4udcA-3pw3A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rbt GLUTATHIONE
TRANSFERASE O1

(Bombyx mori) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		3 MET A 168
GLN A 112
TYR A 108
 None
 1.00A 4udcA-3rbtA:
undetectable		 4udcA-3rbtA:
23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		3 MET A 194
GLN A 230
TYR A  67
 None
 1.07A 4udcA-3ry9A:
36.2		 4udcA-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqd PAX-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF16770
(RTT107_BRCT_5) 		3 MET A1013
GLN A1006
TYR A 979
 None
 1.01A 4udcA-3sqdA:
undetectable		 4udcA-3sqdA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 MET A 440
GLN A 450
TYR A 460
 None
 1.13A 4udcA-3sqwA:
undetectable		 4udcA-3sqwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t12 GLIDING PROTEIN MGLA

(Thermus
thermophilus) 		PF00025
(Arf) 		3 MET A 120
GLN A  82
TYR A  85
 None
ALF  A 200 (-3.8A)
None
 0.73A 4udcA-3t12A:
undetectable		 4udcA-3t12A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqz DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Coxiella
burnetii) 		PF00692
(dUTPase) 		3 MET A  98
GLN A  94
TYR A  58
 None
 1.01A 4udcA-3tqzA:
undetectable		 4udcA-3tqzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		3 MET A 148
GLN A 183
TYR A 233
 None
 1.10A 4udcA-3uj2A:
undetectable		 4udcA-3uj2A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w6q TYROSINASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		3 MET A 198
GLN A 252
TYR A 194
 None
 1.01A 4udcA-3w6qA:
undetectable		 4udcA-3w6qA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apl APICAL MEMBRANE
ANTIGEN 1

(Neospora
caninum) 		PF02430
(AMA-1) 		3 MET A 227
GLN A 119
TYR A 117
 None
 1.01A 4udcA-4aplA:
undetectable		 4udcA-4aplA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 MET A   1
GLN A 284
TYR A 279
 None
 1.06A 4udcA-4bkmA:
undetectable		 4udcA-4bkmA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyv HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 MET B 115
GLN B  42
TYR B  38
 None
 0.82A 4udcA-4cyvB:
undetectable		 4udcA-4cyvB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 MET A 119
GLN A  57
TYR A  53
 None
CL  A 402 (-3.5A)
None
 0.97A 4udcA-4drtA:
undetectable		 4udcA-4drtA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqv HEMAGGLUTININ HA2

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 MET B 115
GLN B  42
TYR B  38
 None
 0.92A 4udcA-4fqvB:
undetectable		 4udcA-4fqvB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 MET A 444
GLN A 546
TYR A 582
 None
 1.00A 4udcA-4fysA:
undetectable		 4udcA-4fysA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		3 MET A 214
GLN A 287
TYR A 283
 None
 0.59A 4udcA-4jxyA:
2.7		 4udcA-4jxyA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		3 MET A  64
GLN A 133
TYR A  69
 PGE  A 402 (-4.2A)
None
None
 0.89A 4udcA-4kryA:
undetectable		 4udcA-4kryA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 3 MET A 113
GLN A 123
TYR A 472
 None
 0.98A 4udcA-4lc9A:
undetectable		 4udcA-4lc9A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvo SUBTILISIN-LIKE
SERINE PROTEASE

(Plasmodium
falciparum) 		PF00082
(Peptidase_S8) 		3 MET A 486
GLN A 508
TYR A 550
 None
 1.07A 4udcA-4lvoA:
undetectable		 4udcA-4lvoA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 MET A 604
GLN A 760
TYR A 598
 None
 1.03A 4udcA-4p6wA:
39.7		 4udcA-4p6wA:
96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc4 30K LIPOPROTEIN

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		3 MET A  62
GLN A  47
TYR A  80
 None
 1.05A 4udcA-4pc4A:
undetectable		 4udcA-4pc4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		3 MET A 258
GLN A 245
TYR A 236
 None
 1.10A 4udcA-4roaA:
undetectable		 4udcA-4roaA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		3 MET A 432
GLN A 317
TYR A 313
 None
 1.03A 4udcA-4yjiA:
undetectable		 4udcA-4yjiA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdf ATP SYNTHASE SUBUNIT
BETA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		3 MET E  58
GLN E 217
TYR E 215
 None
 1.05A 4udcA-5cdfE:
undetectable		 4udcA-5cdfE:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		3 MET A 287
GLN A 329
TYR A 312
 None
 1.03A 4udcA-5cxpA:
undetectable		 4udcA-5cxpA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz TUBULIN GAMMA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		3 MET C  68
GLN C 137
TYR C 170
 None
 1.12A 4udcA-5flzC:
undetectable		 4udcA-5flzC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 MET A  62
GLN A 640
TYR A 618
 None
 1.06A 4udcA-5fr8A:
undetectable		 4udcA-5fr8A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h08 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 MET A1825
GLN A1898
TYR A1864
 None
 1.09A 4udcA-5h08A:
undetectable		 4udcA-5h08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 MET A 694
GLN A 488
TYR A 584
 None
 1.06A 4udcA-5h53A:
undetectable		 4udcA-5h53A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ido 3' TERMINAL URIDYLYL
TRANSFERASE

(Trypanosoma
brucei) 		PF03828
(PAP_assoc) 		3 MET A 585
GLN A 536
TYR A 532
 None
 0.95A 4udcA-5idoA:
undetectable		 4udcA-5idoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv8 LPS BIOSYNTHESIS
PROTEIN

(Klebsiella
pneumoniae) 		PF04453
(OstA_C) 		3 MET A 769
GLN A 710
TYR A 698
 None
 0.96A 4udcA-5iv8A:
undetectable		 4udcA-5iv8A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iv9 LPS-ASSEMBLY PROTEIN
LPTD

(Klebsiella
pneumoniae) 		PF03968
(OstA)
PF04453
(OstA_C) 		3 MET A 746
GLN A 687
TYR A 675
 None
 1.08A 4udcA-5iv9A:
undetectable		 4udcA-5iv9A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		3 MET A 360
GLN A 280
TYR A 279
 None
 1.13A 4udcA-5jryA:
undetectable		 4udcA-5jryA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 MET A 304
GLN A 299
TYR A 277
 None
 0.86A 4udcA-5oljA:
undetectable		 4udcA-5oljA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B

(Methanothermobacter
sp. CaT2) 		PF00384
(Molybdopterin) 		3 MET B 287
GLN B 298
TYR B 394
 None
 1.12A 4udcA-5t5iB:
undetectable		 4udcA-5t5iB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 MET A 680
GLN A 696
TYR A 698
 None
 1.00A 4udcA-5tf0A:
undetectable		 4udcA-5tf0A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr7 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Vibrio cholerae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 MET A 137
GLN A  78
TYR A  74
 None
 1.01A 4udcA-5tr7A:
undetectable		 4udcA-5tr7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um7 THIOREDOXIN
SIGNATURE PROTEIN

(Streptococcus
gordonii) 		PF00578
(AhpC-TSA) 		3 MET A  69
GLN A  55
TYR A  92
 None
 1.04A 4udcA-5um7A:
undetectable		 4udcA-5um7A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 56 KDA U1 SMALL
NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT
PROTEIN NAM8

(Saccharomyces
cerevisiae) 		no annotation 3 MET G 281
GLN F 407
TYR G 291
 None
 1.10A 4udcA-5uz5G:
undetectable		 4udcA-5uz5G:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		no annotation 3 MET A 207
GLN A 266
TYR A 275
 None
 0.93A 4udcA-5wm0A:
undetectable		 4udcA-5wm0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE

(Marinomonas
mediterranea) 		no annotation 3 MET A 179
GLN A 210
TYR A 223
 None
 0.86A 4udcA-5x32A:
undetectable		 4udcA-5x32A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y69 CHAIN A

(Listeria
monocytogenes) 		no annotation 3 MET A  52
GLN A  34
TYR A  42
 None
 1.06A 4udcA-5y69A:
undetectable		 4udcA-5y69A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yvf -

(-) 		no annotation 3 MET A 343
GLN A 373
TYR A 390
 None
 0.99A 4udcA-5yvfA:
undetectable		 4udcA-5yvfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8s LOGANIC ACID
O-METHYLTRANSFERASE

(Catharanthus
roseus) 		no annotation 3 MET A  88
GLN A  38
TYR A 159
 None
 1.13A 4udcA-6c8sA:
undetectable		 4udcA-6c8sA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8d HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		no annotation 3 MET B 115
GLN B  42
TYR B  38
 None
 0.94A 4udcA-6d8dB:
undetectable		 4udcA-6d8dB:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fls -

(-) 		no annotation 3 MET A 107
GLN A 123
TYR A 124
 None
 1.14A 4udcA-6flsA:
undetectable		 4udcA-6flsA:
undetectable