SIMILAR PATTERNS OF AMINO ACIDS FOR 4UDC_A_DEXA1778_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1i META CLEAVAGE
COMPOUND HYDROLASE

(Janthinobacterium) 		PF12697
(Abhydrolase_6) 		5 LEU A 170
GLY A 260
MET A 264
ILE A 177
PHE A 175
 None
 1.01A 4udcA-1j1iA:
undetectable		 4udcA-1j1iA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q25 CATION-INDEPENDENT
MANNOSE 6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF00878
(CIMR) 		5 LEU A 214
GLY A 213
TRP A  17
THR A  99
ILE A 152
 None
 1.28A 4udcA-1q25A:
undetectable		 4udcA-1q25A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqu ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE 2

(Nostoc sp. PCC
7120) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 LEU A  57
ASN A  58
GLY A  61
MET A  70
ILE A 194
 None
 0.99A 4udcA-1vquA:
undetectable		 4udcA-1vquA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY

(Thermotoga
maritima) 		PF00294
(PfkB) 		5 LEU A   7
ASN A   8
GLY A 142
GLN A 171
THR A  92
 None
 1.38A 4udcA-2ajrA:
undetectable		 4udcA-2ajrA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
MET A 742
ARG A 752
MET A 787
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 0.90A 4udcA-2ax9A:
32.1		 4udcA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 742
ARG A 752
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
 0.85A 4udcA-2ax9A:
32.1		 4udcA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 704
ASN A 705
GLY A 708
GLN A 711
PHE A 891
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
None
 0.71A 4udcA-2ax9A:
32.1		 4udcA-2ax9A:
46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzg THIOPURINE
S-METHYLTRANSFERASE

(Homo sapiens) 		PF05724
(TPMT) 		5 LEU A 185
GLY A 153
TRP A 150
ARG A 226
ILE A 204
 None
SAH  A1246 (-3.9A)
None
None
None
 1.46A 4udcA-2bzgA:
undetectable		 4udcA-2bzgA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqx MEMBRANE LIPOPROTEIN
TMPC

(Treponema
pallidum) 		PF02608
(Bmp) 		5 MET A 158
LEU A 160
GLY A 164
MET A 258
PHE A 149
 GMP  A 400 (-3.5A)
None
None
None
None
 1.46A 4udcA-2fqxA:
undetectable		 4udcA-2fqxA:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 268
TRP A 305
MET A 306
ARG A 316
ILE A 438
 OHT  A 500 (-4.1A)
None
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
None
 1.09A 4udcA-2gpvA:
25.4		 4udcA-2gpvA:
31.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 247 (-2.9A)
None
None
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 1.03A 4udcA-2q3yA:
36.2		 4udcA-2q3yA:
58.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
THR A 208
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 (-3.4A)
 0.69A 4udcA-2q3yA:
36.2		 4udcA-2q3yA:
58.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		8 LEU A  32
ASN A  33
GLN A  39
TRP A  69
MET A  70
ARG A  80
THR A 208
PHE A 219
 1CA  A 247 (-4.0A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
None
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.4A)
1CA  A 247 (-4.5A)
 0.60A 4udcA-2q3yA:
36.2		 4udcA-2q3yA:
58.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		5 MET A  73
LEU A  74
THR A 136
ILE A 161
PHE A 163
 None
 1.49A 4udcA-3aqiA:
undetectable		 4udcA-3aqiA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkh LACCASE-1

(Melanocarpus
albomyces) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 230
ASN A 231
GLY A 270
MET A  65
PHE A 238
 None
 1.44A 4udcA-3dkhA:
undetectable		 4udcA-3dkhA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il3 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Haemophilus
influenzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A 247
ASN A 246
GLN A 244
MET A 261
PHE A 212
 None
 1.21A 4udcA-3il3A:
undetectable		 4udcA-3il3A:
20.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 719
TRP A 755
MET A 756
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-3.3A)
None
WOW  A   1 ( 4.1A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 1.25A 4udcA-3kbaA:
35.2		 4udcA-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 722
GLN A 725
MET A 756
ARG A 766
MET A 801
 WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
 0.98A 4udcA-3kbaA:
35.2		 4udcA-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 718
ASN A 719
GLY A 722
MET A 756
ARG A 766
MET A 801
THR A 894
PHE A 905
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-3.9A)
WOW  A   1 (-4.6A)
 0.81A 4udcA-3kbaA:
35.2		 4udcA-3kbaA:
49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME

([Candida]
glabrata) 		PF02110
(HK)
PF02581
(TMP-TENI) 		5 LEU A 485
ASN A 484
GLY A 483
ARG A 335
THR A 248
 None
 1.22A 4udcA-3nm1A:
undetectable		 4udcA-3nm1A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6h ENOYL-COA HYDRATASE,
ECHA3

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 LEU A  79
GLY A  82
GLN A  31
ILE A 137
PHE A 110
 None
 1.40A 4udcA-3r6hA:
undetectable		 4udcA-3r6hA:
17.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.00A 4udcA-3ry9A:
36.2		 4udcA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
THR A 208
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.78A 4udcA-3ry9A:
36.2		 4udcA-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf5 ALANINE RACEMASE

(Aeromonas
hydrophila) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 MET A 190
LEU A 193
GLY A 195
GLN A 154
ILE A 164
 None
 1.01A 4udcA-4bf5A:
undetectable		 4udcA-4bf5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE

(Rhodococcus
jostii) 		PF01494
(FAD_binding_3) 		5 LEU A 390
GLY A 392
ARG A 344
ILE A  91
PHE A  97
 None
 1.31A 4udcA-4bk1A:
undetectable		 4udcA-4bk1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e7w GLYCOGEN SYNTHASE
KINASE 3

(Ustilago maydis) 		PF00069
(Pkinase) 		5 MET A 228
LEU A 231
GLY A 234
ILE A 298
PHE A 286
 None
 1.20A 4udcA-4e7wA:
undetectable		 4udcA-4e7wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 LEU A  79
GLY A  82
GLN A  31
ILE A 137
PHE A 110
 None
 1.41A 4udcA-4fn7A:
undetectable		 4udcA-4fn7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hln STARCH SYNTHASE I

(Hordeum vulgare) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 360
GLY A 356
TRP A 346
THR A 339
ILE A 278
 None
 1.32A 4udcA-4hlnA:
undetectable		 4udcA-4hlnA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE

(Saccharomyces
cerevisiae) 		PF01063
(Aminotran_4) 		5 GLY A 361
GLN A 125
THR A 318
ILE A 340
PHE A 359
 PLP  A 500 (-3.7A)
PLP  A 500 ( 4.3A)
None
None
None
 1.50A 4udcA-4k6nA:
undetectable		 4udcA-4k6nA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 283
TRP A 320
MET A 321
ARG A 331
PHE A 462
 None
 0.73A 4udcA-4n1yA:
27.9		 4udcA-4n1yA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nul FLAVODOXIN

(Clostridium
beijerinckii) 		PF00258
(Flavodoxin_1) 		5 GLY A  52
MET A  96
MET A 103
ILE A 135
PHE A 131
 None
 1.37A 4udcA-4nulA:
undetectable		 4udcA-4nulA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nul FLAVODOXIN

(Clostridium
beijerinckii) 		PF00258
(Flavodoxin_1) 		5 LEU A  51
GLY A  52
MET A  96
ILE A 135
PHE A 131
 None
 1.27A 4udcA-4nulA:
undetectable		 4udcA-4nulA:
18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ASN A 564
GLY A 568
GLN A 570
TRP A 600
MET A 601
ILE A 747
PHE A 749
 MOF  A 801 (-3.0A)
None
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 1.13A 4udcA-4p6wA:
39.7		 4udcA-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 560
LEU A 563
ASN A 564
GLY A 567
GLN A 570
TRP A 600
MET A 601
ARG A 611
MET A 646
THR A 739
ILE A 747
PHE A 749
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 (-3.9A)
MOF  A 801 ( 4.4A)
MOF  A 801 (-4.4A)
 0.52A 4udcA-4p6wA:
39.7		 4udcA-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 770
GLY A 774
GLN A 776
TRP A 806
THR A 945
PHE A 956
 CV7  A1987 (-3.1A)
None
CV7  A1987 (-3.0A)
None
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 1.28A 4udcA-4udbA:
35.2		 4udcA-4udbA:
51.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
THR A 945
PHE A 956
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.0A)
None
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 (-3.1A)
CV7  A1987 ( 4.7A)
 0.64A 4udcA-4udbA:
35.2		 4udcA-4udbA:
51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evy SALICYLATE
HYDROXYLASE

(Pseudomonas
putida) 		PF01494
(FAD_binding_3) 		5 GLY X 326
GLN X 327
ARG X 363
ILE X  63
PHE X 112
 None
 1.47A 4udcA-5evyX:
undetectable		 4udcA-5evyX:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		5 MET A1470
LEU A1473
GLY A1476
ILE A1410
PHE A1430
 None
 1.15A 4udcA-5f3yA:
undetectable		 4udcA-5f3yA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f3y UNCONVENTIONAL
MYOSIN-VIIB

(Mus musculus) 		PF00784
(MyTH4) 		5 MET A1470
LEU A1473
GLY A1477
ILE A1410
PHE A1430
 None
 1.23A 4udcA-5f3yA:
undetectable		 4udcA-5f3yA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 LEU A 155
GLY A 126
THR A 280
ILE A 157
PHE A 285
 None
 1.44A 4udcA-5fv4A:
undetectable		 4udcA-5fv4A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00146
(NADHdh)
PF00499
(Oxidored_q3) 		5 LEU J  45
ASN J  46
GLY J  48
MET H  98
ILE J   5
 None
 1.40A 4udcA-5lc5J:
undetectable		 4udcA-5lc5J:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 6 ASN A 770
GLY A 774
GLN A 776
TRP A 806
THR A 945
PHE A 956
 ECV  A1101 (-3.1A)
None
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 1.28A 4udcA-5mwpA:
35.0		 4udcA-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
TRP A 806
MET A 807
ARG A 817
MET A 852
 ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.24A 4udcA-5mwpA:
35.0		 4udcA-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 8 LEU A 769
ASN A 770
GLN A 776
TRP A 806
MET A 807
ARG A 817
THR A 945
PHE A 956
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
None
ECV  A1101 (-3.6A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.2A)
ECV  A1101 ( 4.7A)
 0.56A 4udcA-5mwpA:
35.0		 4udcA-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 6 GLY A 563
GLN A 566
TRP A 596
MET A 597
ARG A 607
MET A 642
 486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.73A 4udcA-5uc1A:
26.8		 4udcA-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 8 MET A 556
LEU A 559
ASN A 560
GLY A 563
GLN A 566
MET A 597
ARG A 607
MET A 642
 None
486  A 801 (-4.7A)
486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.90A 4udcA-5uc1A:
26.8		 4udcA-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLY A  37
TRP A  69
MET A  70
THR A 208
PHE A 218
 1TA  A 301 (-3.0A)
None
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.92A 4udcA-5ufsA:
38.9		 4udcA-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		11 MET A  29
LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
THR A 208
PHE A 218
 1TA  A 301 ( 2.9A)
1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 (-3.0A)
1TA  A 301 (-4.0A)
 0.51A 4udcA-5ufsA:
38.9		 4udcA-5ufsA:
71.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yjh PERIOSTIN

(Homo sapiens) 		no annotation 5 MET A 174
LEU A 175
GLY A 214
ILE A 170
PHE A 135
 None
None
CL  A 711 ( 4.4A)
None
None
 0.98A 4udcA-5yjhA:
undetectable		 4udcA-5yjhA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au8 GOLGI TO ER TRAFFIC
PROTEIN 4 HOMOLOG
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		no annotation 5 LEU A 236
GLN C1023
THR A 220
ILE A 226
PHE A 232
 None
 1.46A 4udcA-6au8A:
undetectable		 4udcA-6au8A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 5 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.02A 4udcA-6e85A:
undetectable		 4udcA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsh OXYB PROTEIN

(Actinoplanes
teichomyceticus) 		no annotation 5 LEU A  88
ASN A  87
GLY A  86
ARG A  98
THR A 287
 HEM  A 401 (-3.3A)
None
None
None
HEM  A 401 (-3.8A)
 1.47A 4udcA-6fshA:
undetectable		 4udcA-6fshA:
13.67