SIMILAR PATTERNS OF AMINO ACIDS FOR 4UDA_A_DEXA1985

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		5 LEU A  64
ALA A 328
MET A  22
LEU A  27
PHE A 333
 None
 1.44A 4udaA-1icpA:
undetectable		 4udaA-1icpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 ALA A 228
GLN A 231
SER A 235
CYH A 245
PHE A 152
 None
 1.34A 4udaA-1v7vA:
undetectable		 4udaA-1v7vA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664

(Listeria
innocua) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A1147
ASN A1151
GLN A1156
ARG A1322
LEU A1184
 None
 1.48A 4udaA-1wufA:
undetectable		 4udaA-1wufA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 701
ASN A 705
GLN A 711
MET A 742
ARG A 752
MET A 780
LEU A 873
PHE A 891
 None
BHM  A   1 (-3.6A)
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-4.4A)
None
 0.96A 4udaA-2ax9A:
35.8		 4udaA-2ax9A:
52.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 701
GLN A 711
MET A 742
ARG A 752
MET A 780
MET A 787
LEU A 873
 None
BHM  A   1 (-2.2A)
BHM  A   1 ( 4.0A)
BHM  A   1 (-3.8A)
BHM  A   1 ( 4.3A)
BHM  A   1 (-3.6A)
BHM  A   1 (-4.4A)
 0.95A 4udaA-2ax9A:
35.8		 4udaA-2ax9A:
52.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k77 NEGATIVE REGULATOR
OF GENETIC
COMPETENCE CLPC/MECB

(Bacillus
subtilis) 		PF02861
(Clp_N) 		5 LEU A 112
ALA A  47
GLN A  51
SER A  57
LEU A  36
 None
 1.27A 4udaA-2k77A:
undetectable		 4udaA-2k77A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n84 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF00498
(FHA) 		5 LEU A  87
ALA A 152
SER A 156
CYH A  71
PHE A 119
 None
 1.19A 4udaA-2n84A:
undetectable		 4udaA-2n84A:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		11 LEU A  29
ASN A  33
ALA A  36
GLN A  39
MET A  70
ARG A  80
MET A 108
MET A 115
LEU A 201
CYH A 205
PHE A 219
 1CA  A 247 ( 3.6A)
1CA  A 247 (-2.9A)
1CA  A 247 (-3.6A)
1CA  A 247 (-3.1A)
1CA  A 247 ( 3.8A)
1CA  A 247 (-3.8A)
1CA  A 247 (-3.9A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
1CA  A 247 (-4.0A)
1CA  A 247 (-4.5A)
 0.50A 4udaA-2q3yA:
38.8		 4udaA-2q3yA:
73.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e53 FATTY-ACID-COA
LIGASE FADD28

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		5 LEU A 195
ASN A 191
MET A 183
SER A 184
ARG A   4
 None
 1.42A 4udaA-3e53A:
undetectable		 4udaA-3e53A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eua PUTATIVE
FRUCTOSE-AMINOACID-6
-PHOSPHATE DEGLYCASE

(Bacillus
subtilis) 		PF01380
(SIS) 		5 LEU A 167
ALA A 174
GLN A 177
SER A 279
LEU A 251
 None
 1.26A 4udaA-3euaA:
undetectable		 4udaA-3euaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3irv CYSTEINE HYDROLASE

(Pseudomonas
savastanoi) 		PF00857
(Isochorismatase) 		5 LEU A 197
ASN A 201
ALA A 202
MET A  57
LEU A 135
 None
 1.34A 4udaA-3irvA:
undetectable		 4udaA-3irvA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 GLN A 725
MET A 756
ARG A 766
MET A 801
LEU A 887
CYH A 891
 WOW  A   1 ( 4.1A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
 0.82A 4udaA-3kbaA:
36.0		 4udaA-3kbaA:
55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 715
ASN A 719
MET A 756
ARG A 766
MET A 801
LEU A 887
CYH A 891
PHE A 905
 WOW  A   1 (-3.9A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
WOW  A   1 (-3.5A)
WOW  A   1 (-4.6A)
 0.58A 4udaA-3kbaA:
36.0		 4udaA-3kbaA:
55.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		10 LEU A  29
ASN A  33
GLN A  39
MET A  70
ARG A  80
MET A 108
MET A 115
LEU A 201
CYH A 205
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-4.3A)
 0.38A 4udaA-3ry9A:
38.2		 4udaA-3ry9A:
70.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 352
ALA A 329
GLN A 326
MET A 110
LEU A  52
 None
 1.28A 4udaA-3ugvA:
undetectable		 4udaA-3ugvA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqg SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Polaromonas sp.
JS666) 		no annotation 5 LEU C  68
ALA C  59
GLN C  58
CYH C 119
PHE C  71
 None
 1.38A 4udaA-4iqgC:
undetectable		 4udaA-4iqgC:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 280
ALA A 287
MET A 321
ARG A 331
MET A 358
PHE A 462
 None
 0.80A 4udaA-4n1yA:
28.9		 4udaA-4n1yA:
27.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		5 LEU A 236
ALA A 243
GLN A 246
SER A 171
PHE A 163
 None
 1.11A 4udaA-4o2iA:
undetectable		 4udaA-4o2iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2i NON-LEE ENCODED TYPE
III EFFECTOR C

(Citrobacter
rodentium) 		PF13678
(Peptidase_M85) 		5 LEU A 236
ASN A 240
ALA A 243
GLN A 246
SER A 171
 None
 1.40A 4udaA-4o2iA:
undetectable		 4udaA-4o2iA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Sulfurospirillum
deleyianum) 		PF03480
(DctP) 		5 LEU A 232
ALA A 205
SER A 149
LEU A 209
PHE A 190
 SIN  A 401 ( 4.3A)
None
None
None
SIN  A 401 (-2.5A)
 1.33A 4udaA-4ovsA:
undetectable		 4udaA-4ovsA:
20.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 ASN A 564
GLN A 570
MET A 601
ARG A 611
MET A 646
LEU A 732
CYH A 736
PHE A 749
 MOF  A 801 (-3.0A)
MOF  A 801 (-2.9A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
MOF  A 801 (-3.7A)
MOF  A 801 (-4.4A)
 0.62A 4udaA-4p6wA:
35.5		 4udaA-4p6wA:
56.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon) 		5 LEU A 182
ALA A 193
MET A 538
SER A 198
MET A 587
 None
 1.41A 4udaA-4rulA:
undetectable		 4udaA-4rulA:
13.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 LEU A 766
ASN A 770
ALA A 773
GLN A 776
MET A 807
ARG A 817
MET A 852
LEU A 938
CYH A 942
PHE A 956
 CV7  A1987 (-3.6A)
CV7  A1987 (-3.1A)
CV7  A1987 (-3.5A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.7A)
 0.26A 4udaA-4udbA:
38.5		 4udaA-4udbA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		5 ALA A  52
GLN A  51
SER A 148
LEU A 153
PHE A 359
 None
 1.38A 4udaA-4uwqA:
undetectable		 4udaA-4uwqA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		5 LEU A 377
ASN A 378
SER A 501
MET A 348
LEU A 370
 None
 1.46A 4udaA-4wisA:
2.3		 4udaA-4wisA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjv RIBOSOME ASSEMBLY
PROTEIN 4

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 LEU A 468
SER A 495
ARG A 335
MET A 159
LEU A 512
 None
 1.44A 4udaA-4wjvA:
undetectable		 4udaA-4wjvA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5p CYTOCHROME P450
HYDROXYLASE

(Streptomyces
atroolivaceus) 		PF00067
(p450) 		5 LEU A 153
ALA A 103
MET A 112
LEU A 353
PHE A 229
 None
None
None
HEM  A 401 ( 4.8A)
HEM  A 401 ( 4.9A)
 1.32A 4udaA-4z5pA:
undetectable		 4udaA-4z5pA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7w UPF0234 PROTEIN
XC_3703

(Xanthomonas
campestris) 		PF04461
(DUF520) 		5 LEU A 154
ALA A 143
GLN A 139
ARG A 135
LEU A 112
 None
 1.41A 4udaA-5b7wA:
undetectable		 4udaA-5b7wA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxx ARTEMISINIC ALDEHYDE
DELTA(11(13))
REDUCTASE

(Artemisia annua) 		PF00724
(Oxidored_FMN) 		5 LEU A  55
ALA A 337
MET A  13
LEU A  18
PHE A 342
 None
 1.49A 4udaA-5dxxA:
undetectable		 4udaA-5dxxA:
20.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 7 ALA A 773
GLN A 776
MET A 807
SER A 810
ARG A 817
MET A 852
LEU A 938
 ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-3.4A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 0.93A 4udaA-5mwpA:
39.9		 4udaA-5mwpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 11 LEU A 766
ASN A 770
ALA A 773
GLN A 776
MET A 807
SER A 810
ARG A 817
MET A 845
LEU A 938
CYH A 942
PHE A 956
 ECV  A1101 ( 3.9A)
ECV  A1101 (-3.1A)
ECV  A1101 (-3.8A)
ECV  A1101 (-2.9A)
ECV  A1101 (-3.6A)
ECV  A1101 (-3.4A)
ECV  A1101 (-4.0A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.7A)
 0.59A 4udaA-5mwpA:
39.9		 4udaA-5mwpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 ASN A 560
GLN A 566
MET A 597
ARG A 607
MET A 642
 486  A 801 (-4.2A)
486  A 801 (-2.8A)
CPS  A 803 ( 3.9A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.92A 4udaA-5uc1A:
23.5		 4udaA-5uc1A:
53.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		5 ASN A  33
GLN A  39
ARG A  80
MET A 108
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 3.0A)
1TA  A 301 (-4.0A)
 0.89A 4udaA-5ufsA:
37.3		 4udaA-5ufsA:
62.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		8 ASN A  33
GLN A  39
MET A  70
ARG A  80
MET A 115
LEU A 201
CYH A 205
PHE A 218
 1TA  A 301 (-3.0A)
1TA  A 301 (-3.0A)
1TA  A 301 ( 3.1A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
1TA  A 301 (-3.6A)
1TA  A 301 (-4.0A)
 0.36A 4udaA-5ufsA:
37.3		 4udaA-5ufsA:
62.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 LEU M  68
ALA M 232
MET M 294
SER M 290
LEU M 315
 3PE  M 503 ( 4.2A)
None
None
None
None
 1.46A 4udaA-6g2jM:
undetectable		 4udaA-6g2jM:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 LEU A 290
LEU A 277
THR A 241
VAL A 255
 None
 1.02A 4udaA-1a5cA:
undetectable		 4udaA-1a5cA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhd UTROPHIN

(Homo sapiens) 		PF00307
(CH) 		4 LEU A 189
TRP A 199
LEU A 211
VAL A 160
 None
 1.01A 4udaA-1bhdA:
undetectable		 4udaA-1bhdA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 LEU A 128
LEU A 255
PHE A 254
VAL A 245
 None
HBI  A 700 (-4.7A)
HBI  A 700 (-3.6A)
None
 0.97A 4udaA-1dmwA:
undetectable		 4udaA-1dmwA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		4 LEU A 392
LEU A 132
THR A  98
VAL A  70
 None
SO4  A 903 (-4.2A)
None
None
 1.08A 4udaA-1e3hA:
0.0		 4udaA-1e3hA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 LEU A1283
LEU A1270
THR A1234
VAL A1248
 None
2FP  A5001 ( 3.9A)
None
None
 1.01A 4udaA-1fdjA:
0.0		 4udaA-1fdjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzh TUMOR SUPPRESSOR
P53-BINDING PROTEIN
1

(Homo sapiens) 		no annotation 4 LEU B1819
TRP B1888
PHE B1791
THR B1894
 None
 1.12A 4udaA-1gzhB:
undetectable		 4udaA-1gzhB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 LEU C 566
LEU C 554
PHE C 508
VAL C 572
 None
 1.05A 4udaA-1h2tC:
0.0		 4udaA-1h2tC:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		4 LEU A 788
LEU A 794
PHE A 755
THR A 751
 None
 1.07A 4udaA-1hu3A:
1.8		 4udaA-1hu3A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 LEU A 225
LEU A 322
PHE A   6
THR A   4
 None
 1.11A 4udaA-1i7oA:
undetectable		 4udaA-1i7oA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 483
LEU A 593
PHE A 493
VAL A 529
 None
 0.99A 4udaA-1k2pA:
0.0		 4udaA-1k2pA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks5 ENDOGLUCANASE A

(Aspergillus
niger) 		PF01670
(Glyco_hydro_12) 		4 TRP A 144
LEU A 100
THR A  81
VAL A  83
 None
 1.10A 4udaA-1ks5A:
undetectable		 4udaA-1ks5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mnn NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		4 LEU A 131
LEU A 190
PHE A 120
THR A 122
 None
 1.07A 4udaA-1mnnA:
undetectable		 4udaA-1mnnA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 LEU A 601
LEU A 618
PHE A 547
VAL A 609
 None
 1.09A 4udaA-1nneA:
undetectable		 4udaA-1nneA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		4 LEU A 128
LEU A 255
PHE A 254
VAL A 245
 None
 1.03A 4udaA-1phzA:
undetectable		 4udaA-1phzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px5 2'-5'-OLIGOADENYLATE
SYNTHETASE 1

(Sus scrofa) 		PF01909
(NTP_transf_2)
PF10421
(OAS1_C) 		4 LEU A  81
LEU A  91
THR A 187
VAL A  78
 None
 1.11A 4udaA-1px5A:
undetectable		 4udaA-1px5A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 LEU A 130
LEU A 500
THR A 415
VAL A 409
 None
 1.04A 4udaA-1sjpA:
undetectable		 4udaA-1sjpA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		4 LEU A 150
LEU A 102
THR A  92
VAL A  88
 None
 1.06A 4udaA-1udxA:
undetectable		 4udaA-1udxA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgk RIKEN CDNA
2900073H19 PROTEIN

(Mus musculus) 		PF09138
(Urm1) 		4 LEU A  48
LEU A  57
PHE A  64
VAL A  76
 None
 1.00A 4udaA-1wgkA:
undetectable		 4udaA-1wgkA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 240
LEU A 229
THR A 202
VAL A 208
 None
 1.04A 4udaA-1xdiA:
undetectable		 4udaA-1xdiA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfc ALANINE RACEMASE

(Mycobacterium
tuberculosis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 195
LEU A 222
THR A 136
VAL A 134
 None
 1.08A 4udaA-1xfcA:
undetectable		 4udaA-1xfcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		4 LEU A  44
LEU A  67
THR A  13
VAL A  39
 None
 1.11A 4udaA-1y9uA:
undetectable		 4udaA-1y9uA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0k GTP-BINDING PROTEIN

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A  12
LEU A  59
PHE A 162
VAL A  87
 None
 1.03A 4udaA-1z0kA:
undetectable		 4udaA-1z0kA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fjk FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Thermus
caldophilus) 		PF01116
(F_bP_aldolase) 		4 LEU A 133
PHE A 161
THR A 165
VAL A 119
 None
 1.02A 4udaA-2fjkA:
undetectable		 4udaA-2fjkA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 LEU B 373
LEU B 346
PHE B 309
VAL B 354
 None
 1.12A 4udaA-2fpgB:
undetectable		 4udaA-2fpgB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv2 RCD1 REQUIRED FOR
CELL
DIFFERENTIATION1
HOMOLOG

(Homo sapiens) 		PF04078
(Rcd1) 		4 LEU A 103
LEU A  95
PHE A 141
THR A 145
 None
 0.95A 4udaA-2fv2A:
undetectable		 4udaA-2fv2A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fv5 ADAM 17

(Homo sapiens) 		PF13688
(Reprolysin_5) 		4 LEU A 251
PHE A 338
THR A 385
VAL A 402
 None
None
None
541  A   1 ( 4.1A)
 1.09A 4udaA-2fv5A:
undetectable		 4udaA-2fv5A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7u TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 LEU A 242
PHE A 233
THR A  99
VAL A  95
 None
 1.09A 4udaA-2g7uA:
undetectable		 4udaA-2g7uA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gef PROTEASE VP4

(Blotched
snakehead virus) 		PF01768
(Birna_VP4) 		4 LEU A 728
LEU A 603
THR A 712
VAL A 723
 None
 0.99A 4udaA-2gefA:
undetectable		 4udaA-2gefA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kco 30S RIBOSOMAL
PROTEIN S8E

(Sulfolobus
solfataricus) 		PF01201
(Ribosomal_S8e) 		4 LEU A 126
LEU A  82
THR A 104
VAL A  65
 None
 1.05A 4udaA-2kcoA:
undetectable		 4udaA-2kcoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwq PROBABLE SHORT-CHAIN
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		4 LEU A  82
LEU A 115
PHE A 162
VAL A 177
 None
 0.95A 4udaA-2nwqA:
undetectable		 4udaA-2nwqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4t BH3976 PROTEIN

(Bacillus
halodurans) 		PF06304
(DUF1048) 		4 LEU A  23
PHE A  60
THR A  74
VAL A  78
 None
None
None
PEG  A   1 (-4.1A)
 1.10A 4udaA-2o4tA:
undetectable		 4udaA-2o4tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p97 HYPOTHETICAL PROTEIN

(Trichormus
variabilis) 		PF14597
(Lactamase_B_5) 		4 LEU A 195
LEU A 149
THR A 134
VAL A 176
 None
 1.06A 4udaA-2p97A:
undetectable		 4udaA-2p97A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 LEU A 245
LEU A 240
PHE A 269
VAL A 282
 None
 1.09A 4udaA-2pcqA:
undetectable		 4udaA-2pcqA:
23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		4 LEU A  28
PHE A 204
THR A 208
VAL A 217
 None
1CA  A 247 (-4.7A)
1CA  A 247 (-3.4A)
None
 0.98A 4udaA-2q3yA:
38.8		 4udaA-2q3yA:
73.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
TRP A  69
LEU A 111
PHE A 204
THR A 208
VAL A 217
 1CA  A 247 (-4.0A)
None
None
1CA  A 247 (-4.7A)
1CA  A 247 (-3.4A)
None
 0.48A 4udaA-2q3yA:
38.8		 4udaA-2q3yA:
73.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4f HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN 1

(Oryza sativa) 		PF01627
(Hpt) 		4 LEU A  14
LEU A 135
PHE A 131
VAL A  23
 None
 1.12A 4udaA-2q4fA:
undetectable		 4udaA-2q4fA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qen WALKER-TYPE ATPASE

(Pyrococcus
abyssi) 		PF01637
(ATPase_2) 		4 LEU A 250
LEU A 212
PHE A 245
THR A 262
 None
 1.11A 4udaA-2qenA:
undetectable		 4udaA-2qenA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		4 LEU A  82
PHE A  95
THR A  56
VAL A  80
 None
 1.10A 4udaA-2ragA:
undetectable		 4udaA-2ragA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 308
LEU A 282
THR A 289
VAL A 312
 None
 0.83A 4udaA-2v6oA:
undetectable		 4udaA-2v6oA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A 297
LEU A  23
PHE A  70
THR A  68
VAL A  65
 None
 1.36A 4udaA-2vsqA:
undetectable		 4udaA-2vsqA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqy ENVELOPE
GLYCOPROTEIN H

(Suid
alphaherpesvirus
1) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 LEU A 589
LEU A 505
PHE A 511
VAL A 576
 None
 1.11A 4udaA-2xqyA:
undetectable		 4udaA-2xqyA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A  85
LEU A  48
THR A 383
VAL A 377
 None
 0.95A 4udaA-2yfkA:
undetectable		 4udaA-2yfkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn2 UNCHARACTERIZED
PROTEIN YNL108C

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		4 TRP A  17
LEU A 234
THR A  72
VAL A 166
 None
 1.10A 4udaA-2yn2A:
undetectable		 4udaA-2yn2A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 174
PHE A 180
THR A 197
VAL A  51
 None
 1.00A 4udaA-3bn1A:
undetectable		 4udaA-3bn1A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		4 LEU A 306
PHE A  88
THR A  92
VAL A  94
 None
 0.91A 4udaA-3bs8A:
undetectable		 4udaA-3bs8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwu PROTEIN FIMF

(Escherichia
coli) 		PF00419
(Fimbrial) 		4 LEU F  96
LEU F 131
PHE F  25
THR F  23
 None
 1.03A 4udaA-3bwuF:
undetectable		 4udaA-3bwuF:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c02 AQUAGLYCEROPORIN

(Plasmodium
falciparum) 		PF00230
(MIP) 		4 LEU A 109
TRP A 124
PHE A 113
THR A  36
 None
 1.11A 4udaA-3c02A:
undetectable		 4udaA-3c02A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TRP A  90
LEU A  59
THR A 216
VAL A 242
 None
 1.11A 4udaA-3ce6A:
undetectable		 4udaA-3ce6A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		4 LEU A 269
PHE A 237
THR A  38
VAL A  30
 None
 1.12A 4udaA-3e38A:
undetectable		 4udaA-3e38A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7d COBH, PRECORRIN-8X
METHYLMUTASE

(Brucella
abortus) 		PF02570
(CbiC) 		4 LEU A  73
LEU A 156
THR A 196
VAL A  79
 None
 1.02A 4udaA-3e7dA:
undetectable		 4udaA-3e7dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 716
TRP A 793
LEU A 688
THR A 580
 None
 0.85A 4udaA-3ecnA:
1.6		 4udaA-3ecnA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 LEU A 554
LEU A 573
THR A 493
VAL A 472
 None
 1.04A 4udaA-3eqnA:
undetectable		 4udaA-3eqnA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		4 LEU A 273
PHE A 210
THR A 208
VAL A 112
 None
 1.03A 4udaA-3ez1A:
undetectable		 4udaA-3ez1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 LEU A  76
LEU A  99
THR A  86
VAL A  36
 NAG  A 521 (-4.2A)
FAD  A   1 (-4.4A)
None
None
 1.08A 4udaA-3fw8A:
undetectable		 4udaA-3fw8A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gay FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Giardia
intestinalis) 		PF01116
(F_bP_aldolase) 		4 LEU A 136
PHE A 161
THR A 165
VAL A 122
 None
 1.10A 4udaA-3gayA:
undetectable		 4udaA-3gayA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A  71
LEU A  36
PHE A 108
VAL A 335
 None
 1.01A 4udaA-3gazA:
undetectable		 4udaA-3gazA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 TRP A  83
LEU A  52
THR A 197
VAL A 223
 None
 1.10A 4udaA-3glqA:
undetectable		 4udaA-3glqA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hf8 TRYPTOPHAN
5-HYDROXYLASE 1

(Homo sapiens) 		PF00351
(Biopterin_H) 		4 LEU A 115
LEU A 242
PHE A 241
VAL A 232
 None
 1.01A 4udaA-3hf8A:
undetectable		 4udaA-3hf8A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 LEU A 175
LEU A 136
THR A 170
VAL A 100
 None
 0.91A 4udaA-3hxlA:
undetectable		 4udaA-3hxlA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 LEU A  56
LEU A 392
THR A 110
VAL A 441
 None
 1.06A 4udaA-3ihgA:
undetectable		 4udaA-3ihgA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 718
LEU A 797
THR A 894
VAL A 903
 WOW  A   1 (-4.2A)
WOW  A   1 ( 4.5A)
WOW  A   1 (-3.9A)
None
 0.62A 4udaA-3kbaA:
36.0		 4udaA-3kbaA:
55.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 LEU A 282
LEU A 269
THR A 233
VAL A 247
 None
CIT  A 400 (-4.0A)
None
None
 1.08A 4udaA-3kx6A:
undetectable		 4udaA-3kx6A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 LEU A 359
LEU A 436
PHE A 492
THR A 415
 NAG  A 760 (-4.1A)
None
None
None
 1.11A 4udaA-3ppsA:
undetectable		 4udaA-3ppsA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 LEU A 180
LEU A 186
THR A 147
VAL A 128
 None
 0.88A 4udaA-3pxxA:
undetectable		 4udaA-3pxxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc5 PLATELET BINDING
PROTEIN GSPB

(Streptococcus
gordonii) 		no annotation 4 LEU X 373
LEU X 329
THR X 382
VAL X 378
 None
 1.00A 4udaA-3qc5X:
undetectable		 4udaA-3qc5X:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		4 LEU A 202
LEU A 162
THR A 207
VAL A 243
 None
None
None
MN  A 771 (-4.4A)
 0.95A 4udaA-3rl3A:
undetectable		 4udaA-3rl3A:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		4 LEU A  28
PHE A 204
THR A 208
VAL A 217
 None
1CA  A 249 (-4.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
 1.08A 4udaA-3ry9A:
38.2		 4udaA-3ry9A:
70.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		6 LEU A  32
TRP A  69
LEU A 111
PHE A 204
THR A 208
VAL A 217
 1CA  A 249 (-3.9A)
None
None
1CA  A 249 (-4.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
 0.56A 4udaA-3ry9A:
38.2		 4udaA-3ry9A:
70.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		4 LEU B1276
LEU B1209
PHE B1283
VAL B1288
 None
 0.75A 4udaA-3s4wB:
undetectable		 4udaA-3s4wB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tal DNA DOUBLE-STRAND
BREAK REPAIR PROTEIN
NURA

(Pyrococcus
furiosus) 		PF09376
(NurA) 		4 LEU A 146
LEU A 352
PHE A 347
VAL A 138
 None
 0.83A 4udaA-3talA:
undetectable		 4udaA-3talA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uf6 LMO1369 PROTEIN

(Listeria
monocytogenes) 		PF01515
(PTA_PTB) 		4 TRP A  62
LEU A  36
PHE A  43
VAL A  88
 None
 1.08A 4udaA-3uf6A:
undetectable		 4udaA-3uf6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Toxoplasma
gondii) 		PF00342
(PGI) 		4 LEU A 491
LEU A 160
THR A 361
VAL A 498
 None
 1.10A 4udaA-3ujhA:
undetectable		 4udaA-3ujhA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 LEU A 259
PHE A 303
THR A 196
VAL A 177
 None
None
SQS  A 401 ( 4.3A)
SQS  A 401 ( 4.5A)
 1.09A 4udaA-3vzbA:
undetectable		 4udaA-3vzbA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbg FATTY ACID-BINDING
PROTEIN, HEART

(Homo sapiens) 		PF00061
(Lipocalin) 		4 LEU A  94
LEU A 117
THR A  74
VAL A  80
 None
 1.06A 4udaA-3wbgA:
undetectable		 4udaA-3wbgA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zzu ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 LEU A 257
LEU A 271
THR A  26
VAL A 105
 None
 1.05A 4udaA-3zzuA:
undetectable		 4udaA-3zzuA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aez WD REPEAT-CONTAINING
PROTEIN SLP1

(Schizosaccharomyces
pombe) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 LEU A 186
LEU A 444
THR A 408
VAL A 439
 None
 0.95A 4udaA-4aezA:
undetectable		 4udaA-4aezA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		4 LEU A1287
LEU A1341
THR A1314
VAL A1366
 None
 1.05A 4udaA-4amcA:
undetectable		 4udaA-4amcA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 PROTEIN CAF40

(Saccharomyces
cerevisiae) 		PF04078
(Rcd1) 		4 LEU B 205
LEU B 197
PHE B 243
THR B 247
 None
 0.82A 4udaA-4cv5B:
undetectable		 4udaA-4cv5B:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		4 LEU A 722
LEU A 635
THR A 515
VAL A 781
 None
 0.99A 4udaA-4czwA:
undetectable		 4udaA-4czwA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 LEU A  57
TRP A 221
LEU A  63
VAL A  51
 None
 0.96A 4udaA-4dg8A:
undetectable		 4udaA-4dg8A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5v PUTATIVE THUA-LIKE
PROTEIN

(Parabacteroides
merdae) 		PF06283
(ThuA) 		4 LEU A 270
PHE A 265
THR A 245
VAL A 113
 None
 1.12A 4udaA-4e5vA:
undetectable		 4udaA-4e5vA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3h ARGINASE (ROCF)

(Helicobacter
pylori) 		PF00491
(Arginase) 		4 LEU A 231
LEU A 265
THR A 219
VAL A 180
 None
 1.01A 4udaA-4g3hA:
undetectable		 4udaA-4g3hA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		4 LEU A  84
TRP A  34
PHE A  51
THR A 305
 None
 1.00A 4udaA-4gx8A:
undetectable		 4udaA-4gx8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h9p DEATH
DOMAIN-ASSOCIATED
PROTEIN 6

(Homo sapiens) 		no annotation 4 LEU C 290
LEU C 311
THR C 262
VAL C 267
 None
 1.12A 4udaA-4h9pC:
undetectable		 4udaA-4h9pC:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 244
LEU A 218
THR A 225
VAL A 248
 None
 0.84A 4udaA-4j57A:
undetectable		 4udaA-4j57A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 LEU A  51
PHE A 334
THR A 338
VAL A 128
 None
 0.93A 4udaA-4lvqA:
undetectable		 4udaA-4lvqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 295
LEU A 424
THR A 288
VAL A 292
 None
 1.04A 4udaA-4o7pA:
undetectable		 4udaA-4o7pA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh0 SPORE PHOTOPRODUCT
LYASE

(Geobacillus
thermodenitrificans) 		no annotation 4 LEU A 216
PHE A 194
THR A 173
VAL A 145
 None
 1.03A 4udaA-4rh0A:
undetectable		 4udaA-4rh0A:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 765
LEU A 848
PHE A 941
THR A 945
VAL A 954
 None
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.6A)
CV7  A1987 (-3.1A)
None
 0.95A 4udaA-4udbA:
38.5		 4udaA-4udbA:
99.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 769
TRP A 806
LEU A 848
PHE A 941
THR A 945
VAL A 954
 CV7  A1987 (-4.1A)
None
CV7  A1987 ( 4.4A)
CV7  A1987 (-4.6A)
CV7  A1987 (-3.1A)
None
 0.32A 4udaA-4udbA:
38.5		 4udaA-4udbA:
99.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		4 LEU A 483
LEU A 593
PHE A 493
VAL A 529
 None
 1.07A 4udaA-4y93A:
undetectable		 4udaA-4y93A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 LEU D 282
PHE D 259
THR D 258
VAL D 317
 None
 1.11A 4udaA-4yg7D:
undetectable		 4udaA-4yg7D:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqd ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00989
(PAS)
PF08447
(PAS_3) 		4 LEU B  59
LEU B 111
PHE B 110
THR B  66
 None
 1.06A 4udaA-4zqdB:
undetectable		 4udaA-4zqdB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 LEU A 217
LEU A 178
THR A 196
VAL A 183
 None
 1.07A 4udaA-5aa5A:
undetectable		 4udaA-5aa5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmr EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Mus musculus) 		PF03465
(eRF1_3) 		4 LEU B 389
LEU B 326
THR B 308
VAL B 317
 None
 1.08A 4udaA-5dmrB:
undetectable		 4udaA-5dmrB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 LEU B 537
LEU B 548
THR B 583
VAL B 628
 None
 1.08A 4udaA-5eduB:
undetectable		 4udaA-5eduB:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 LEU A 956
LEU A 917
PHE A 935
THR A 960
 None
 1.06A 4udaA-5hzrA:
undetectable		 4udaA-5hzrA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijl DNA POLYMERASE II
LARGE SUBUNIT

(Pyrococcus
abyssi) 		PF03833
(PolC_DP2) 		4 LEU A 249
TRP A 272
LEU A 209
PHE A 278
 None
 1.09A 4udaA-5ijlA:
undetectable		 4udaA-5ijlA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		4 LEU A 438
LEU A 341
PHE A  41
THR A 361
 None
 1.04A 4udaA-5inrA:
undetectable		 4udaA-5inrA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jk6 PHENYLALANINE-4-HYDR
OXYLASE

(Dictyostelium
discoideum) 		PF00351
(Biopterin_H) 		4 LEU A 116
LEU A 243
PHE A 242
VAL A 233
 None
 1.04A 4udaA-5jk6A:
undetectable		 4udaA-5jk6A:
20.05