SIMILAR PATTERNS OF AMINO ACIDS FOR 4UCK_B_SAMB2409_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dow ALPHA-CATENIN

(Mus musculus) 		PF01044
(Vinculin) 		4 SER A 117
GLY A 109
GLU A 110
ASP A 113
 None
 0.81A 4uckB-1dowA:
undetectable		 4uckB-1dowA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea9 CYCLOMALTODEXTRINASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 SER C 419
GLY C 353
GLU C 354
ASP C 369
 None
 1.02A 4uckB-1ea9C:
undetectable		 4uckB-1ea9C:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 SER A 334
GLY A 255
GLU A 254
ASP A 258
 None
 1.06A 4uckB-1ethA:
undetectable		 4uckB-1ethA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gu3 ENDOGLUCANASE C

(Cellulomonas
fimi) 		PF02018
(CBM_4_9) 		4 GLY A  12
GLU A  14
ASP A  26
ASP A  11
 None
 0.85A 4uckB-1gu3A:
undetectable		 4uckB-1gu3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 SER A2710
GLY A2766
ASP A2761
ASP A2768
 None
 0.93A 4uckB-1js8A:
undetectable		 4uckB-1js8A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6a GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAH  A 887 ( 2.8A)
SAH  A 887 (-3.6A)
SAH  A 887 ( 3.3A)
SAH  A 887 (-3.9A)
 0.66A 4uckB-1r6aA:
9.2		 4uckB-1r6aA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		4 GLY A 384
ASP A  37
ASP A  45
ASP A 382
 None
None
EDO  A1223 (-2.8A)
None
 0.98A 4uckB-1szsA:
2.5		 4uckB-1szsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 GLY A 340
GLU A 346
ASP A 351
ASP A 341
 None
 1.05A 4uckB-1vftA:
undetectable		 4uckB-1vftA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A 155
GLY A  41
ASP A  47
ASP A  37
 None
FAD  A 999 (-3.1A)
FAD  A 999 (-3.8A)
FAD  A 999 (-3.5A)
 1.03A 4uckB-1xdiA:
2.4		 4uckB-1xdiA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xng NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Helicobacter
pylori) 		PF02540
(NAD_synthase) 		4 GLY A  34
ASP A 185
ASP A  37
ASP A  70
 None
None
ATP  A 303 (-3.9A)
None
 0.85A 4uckB-1xngA:
undetectable		 4uckB-1xngA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 GLY A 264
GLU A  42
ASP A  20
ASP A  28
 K  A 413 ( 4.5A)
K  A 413 (-2.9A)
None
None
 0.96A 4uckB-1xrcA:
undetectable		 4uckB-1xrcA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzf LIPASE/ACYLHYDROLASE

(Enterococcus
faecalis) 		PF13472
(Lipase_GDSL_2) 		4 SER A 171
GLY A 158
GLU A 161
ASP A 160
 None
 1.01A 4uckB-1yzfA:
2.1		 4uckB-1yzfA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 SER A 301
GLY A 261
ASP A 266
ASP A 259
 None
 1.01A 4uckB-2axqA:
3.3		 4uckB-2axqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bh8 1B11

(Escherichia
coli) 		PF00313
(CSD) 		4 GLY A  21
GLU A  68
ASP A  39
ASP A  43
 None
 0.87A 4uckB-2bh8A:
undetectable		 4uckB-2bh8A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boy 3-CHLOROCATECHOL
1,2-DIOXYGENASE

(Rhodococcus
opacus) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 GLY A 155
GLU A 108
ASP A 111
ASP A 119
 None
 1.03A 4uckB-2boyA:
undetectable		 4uckB-2boyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmj POLY (ADP-RIBOSE)
POLYMERASE FAMILY,
MEMBER 1

(Homo sapiens) 		PF00645
(zf-PARP) 		4 GLY A  80
GLU A  19
ASP A  88
ASP A  75
 None
 1.05A 4uckB-2dmjA:
undetectable		 4uckB-2dmjA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		4 SER A 301
GLU A 356
ASP A 321
ASP A 352
 None
 1.02A 4uckB-2drwA:
undetectable		 4uckB-2drwA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3u HYPOTHETICAL PROTEIN
PH1566

(Pyrococcus
horikoshii) 		PF00013
(KH_1) 		4 GLY A  74
GLU A  75
ASP A  43
ASP A  70
 None
 1.03A 4uckB-2e3uA:
undetectable		 4uckB-2e3uA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk9 PROTEIN KINASE C,
ETA TYPE

(Homo sapiens) 		PF00168
(C2) 		4 SER A 115
GLY A 120
GLU A 119
ASP A 123
 None
 1.01A 4uckB-2fk9A:
undetectable		 4uckB-2fk9A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn5 NEURABIN-1

(Rattus
norvegicus) 		PF00595
(PDZ) 		4 GLY A  45
GLU A  44
ASP A  13
ASP A  51
 None
 1.01A 4uckB-2fn5A:
undetectable		 4uckB-2fn5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 SER A 640
GLY A 607
GLU A 632
ASP A 670
 None
 1.04A 4uckB-2gq3A:
undetectable		 4uckB-2gq3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz6 N-ACETYL-D-GLUCOSAMI
NE 2-EPIMERASE

(Anabaena sp.
CH1) 		PF07221
(GlcNAc_2-epim) 		4 GLY A 232
GLU A 231
ASP A 287
ASP A 210
 None
 0.96A 4uckB-2gz6A:
undetectable		 4uckB-2gz6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kep GENERAL SECRETION
PATHWAY PROTEIN G

(Pseudomonas
aeruginosa) 		PF08334
(T2SSG) 		4 GLY A 135
GLU A 134
ASP A 131
ASP A 138
 None
 0.95A 4uckB-2kepA:
undetectable		 4uckB-2kepA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mq0 MYOSIN-BINDING
PROTEIN C,
CARDIAC-TYPE

(Homo sapiens) 		PF07679
(I-set) 		4 SER A 530
GLY A 481
GLU A 479
ASP A 506
 None
 0.92A 4uckB-2mq0A:
undetectable		 4uckB-2mq0A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		4 SER A  57
GLY A  82
ASP A 132
ASP A 147
 SAM  A 300 (-2.6A)
SAM  A 300 (-3.3A)
SAM  A 300 (-3.9A)
SAM  A 300 (-3.9A)
 0.84A 4uckB-2oxtA:
9.4		 4uckB-2oxtA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oy0 METHYLTRANSFERASE

(West Nile virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.0A)
SAH  A 301 (-3.2A)
SAH  A 301 (-4.2A)
 0.62A 4uckB-2oy0A:
9.8		 4uckB-2oy0A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		4 SER B 196
GLY B 147
ASP B 169
ASP B 120
 None
 0.91A 4uckB-2p1nB:
undetectable		 4uckB-2p1nB:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2px5 GENOME POLYPROTEIN
[CONTAINS: CAPSID
PROTEIN C (CORE
PROTEIN)
ENVELOPE PROTEIN M
(MATRIX PROTEIN)
MAJOR ENVELOPE
PROTEIN E
NON-STRUCTURAL
PROTEIN 1 (NS1)
NON-STRUCTURAL
PROTEIN 2A (NS2A)
FLAVIVIRIN PROTEASE
NS2B REGULATORY
SUBUNIT
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT
NON-STRUCTURAL
PROTEIN 4A (NS4A)
NON-STRUCTURAL
PROTEIN 4B (NS4B)
RNA-DIRECTED RNA
POLYMERASE (EC
2.7.7.48) (NS5)]

(Murray Valley
encephalitis
virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAH  A 500 (-2.5A)
SAH  A 500 (-3.4A)
SAH  A 500 (-3.5A)
SAH  A 500 (-3.6A)
 0.60A 4uckB-2px5A:
9.8		 4uckB-2px5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pz8 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Bacillus
anthracis) 		PF02540
(NAD_synthase) 		4 GLY A  48
ASP A 211
ASP A  51
ASP A  90
 None
GOL  A3309 (-3.2A)
APC  A3001 (-3.7A)
None
 0.96A 4uckB-2pz8A:
undetectable		 4uckB-2pz8A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 SER A 314
GLY A 150
ASP A 130
ASP A  23
 None
 0.99A 4uckB-2qn0A:
undetectable		 4uckB-2qn0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 SER A 644
GLY A 488
GLU A 489
ASP A 511
 ADP  A1001 (-2.4A)
None
ADP  A1001 ( 4.8A)
None
 0.99A 4uckB-2r6fA:
undetectable		 4uckB-2r6fA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmh FIBRONECTIN TYPE III
DOMAIN PROTEIN

(Clostridium
perfringens) 		PF08305
(NPCBM) 		4 GLY A1045
ASP A 928
ASP A 980
ASP A1046
 None
 0.90A 4uckB-2vmhA:
undetectable		 4uckB-2vmhA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 SER A 350
GLY A  69
ASP A 356
ASP A  68
 None
 0.92A 4uckB-2xsgA:
undetectable		 4uckB-2xsgA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0k PYROGLUTATMATE PORIN
OPDO

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 SER A 172
GLY A 195
ASP A 232
ASP A 176
 None
 1.06A 4uckB-2y0kA:
undetectable		 4uckB-2y0kA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF01842
(ACT)
PF13840
(ACT_7) 		4 GLY B  96
ASP B  93
ASP B 143
ASP B  12
 None
 1.05A 4uckB-3ab4B:
undetectable		 4uckB-3ab4B:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 GLY A 109
GLU A 110
ASP A  75
ASP A 105
 None
 0.99A 4uckB-3af5A:
undetectable		 4uckB-3af5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9e CHITINASE A

(Vibrio harveyi) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		4 SER A 204
GLY A 321
ASP A 279
ASP A 332
 None
 0.90A 4uckB-3b9eA:
undetectable		 4uckB-3b9eA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		4 GLY A 425
GLU A 470
ASP A 430
ASP A 424
 None
 0.94A 4uckB-3biwA:
undetectable		 4uckB-3biwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buu UNCHARACTERIZED LOLA
SUPERFAMILY PROTEIN
NE2245

(Nitrosomonas
europaea) 		PF17131
(LolA_like) 		4 GLY A 127
GLU A  69
ASP A 223
ASP A 133
 None
 0.91A 4uckB-3buuA:
undetectable		 4uckB-3buuA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 SER A 229
GLY A 220
ASP A 212
ASP A 221
 None
 0.87A 4uckB-3buzA:
undetectable		 4uckB-3buzA:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evc RNA-DIRECTED RNA
POLYMERASE NS5

(Yellow fever
virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAH  A 901 (-2.6A)
SAH  A 901 (-3.4A)
SAH  A 901 (-3.7A)
SAH  A 901 (-3.8A)
 0.74A 4uckB-3evcA:
9.7		 4uckB-3evcA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fu1 GENERAL SECRETION
PATHWAY PROTEIN G

(Vibrio cholerae) 		PF08334
(T2SSG) 		4 GLY A 123
GLU A 122
ASP A 127
ASP A  32
 None
None
CA  A 301 (-3.1A)
None
 1.04A 4uckB-3fu1A:
undetectable		 4uckB-3fu1A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAM  A4633 (-2.7A)
SAM  A4633 (-3.4A)
SAM  A4633 (-3.7A)
SAM  A4633 (-3.7A)
 0.76A 4uckB-3gczA:
9.6		 4uckB-3gczA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmw BETA-LACTAMASE
INHIBITORY PROTEIN
BLIP-I

(Streptomyces
exfoliatus) 		PF07467
(BLIP) 		4 GLY B  62
GLU B  61
ASP B  19
ASP B  60
 None
PO4  B 158 (-2.7A)
None
PO4  B 158 (-3.3A)
 1.05A 4uckB-3gmwB:
undetectable		 4uckB-3gmwB:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gue UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		4 GLY A 421
GLU A 423
ASP A 412
ASP A 420
 None
 1.01A 4uckB-3gueA:
undetectable		 4uckB-3gueA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvd SERINE
ACETYLTRANSFERASE

(Yersinia pestis) 		PF00132
(Hexapep)
PF06426
(SATase_N) 		4 GLY A 199
GLU A 198
ASP A 250
ASP A 173
 None
 0.74A 4uckB-3gvdA:
undetectable		 4uckB-3gvdA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iht S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE

(Ruegeria
pomeroyi) 		PF12692
(Methyltransf_17) 		4 GLY A  47
GLU A  45
ASP A  90
ASP A 112
 SAM  A 200 (-3.3A)
SAM  A 200 ( 4.8A)
SAM  A 200 (-3.2A)
SAM  A 200 (-3.7A)
 1.01A 4uckB-3ihtA:
7.2		 4uckB-3ihtA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j6d PROTEIN PRGH

(Salmonella
enterica) 		PF09480
(PrgH) 		4 SER A 315
GLY A 329
GLU A 360
ASP A 332
 None
 0.97A 4uckB-3j6dA:
undetectable		 4uckB-3j6dA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkr INTEGRASE

(Bovine
immunodeficiency
virus) 		PF00665
(rve) 		4 SER A 202
GLY A  82
GLU A  78
ASP A 157
 None
 0.86A 4uckB-3kkrA:
undetectable		 4uckB-3kkrA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3knt N-GLYCOSYLASE/DNA
LYASE

(Methanocaldococcus
jannaschii) 		no annotation 4 GLY A 183
GLU A 184
ASP A 142
ASP A 181
 None
 0.99A 4uckB-3kntA:
undetectable		 4uckB-3kntA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SFG  A 301 (-2.6A)
SFG  A 301 (-3.5A)
SFG  A 301 (-3.1A)
SFG  A 301 (-3.8A)
 0.56A 4uckB-3lkzA:
9.5		 4uckB-3lkzA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml4 PROTEIN DOK-7

(Mus musculus) 		PF02174
(IRS) 		4 SER A  48
GLY A   9
GLU A   8
ASP A  92
 None
 1.04A 4uckB-3ml4A:
undetectable		 4uckB-3ml4A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvd REGULATOR OF
CHROMOSOME
CONDENSATION

(Drosophila
melanogaster) 		PF00415
(RCC1) 		4 GLY K 114
GLU K  59
ASP K 120
ASP K 113
 None
 1.01A 4uckB-3mvdK:
undetectable		 4uckB-3mvdK:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nea PEPTIDYL-TRNA
HYDROLASE

(Francisella
tularensis) 		PF01195
(Pept_tRNA_hydro) 		4 GLY A 102
GLU A 103
ASP A 163
ASP A 100
 None
None
None
CL  A 500 ( 4.4A)
 0.90A 4uckB-3neaA:
undetectable		 4uckB-3neaA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 SER A 190
GLY A 221
GLU A 222
ASP A 149
 None
 0.93A 4uckB-3q3uA:
undetectable		 4uckB-3q3uA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5t TCR N30 BETA

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLY A  73
GLU A  53
ASP A  25
ASP A  52
 None
 1.00A 4uckB-3q5tA:
undetectable		 4uckB-3q5tA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qve HMG BOX-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF08517
(AXH) 		4 GLY A 261
ASP A 283
ASP A 332
ASP A 260
 EDO  A  13 (-4.4A)
EDO  A  13 (-4.9A)
None
None
 0.99A 4uckB-3qveA:
undetectable		 4uckB-3qveA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tos CALS11

(Micromonospora
echinospora) 		PF05711
(TylF) 		4 GLY A  77
GLU A  75
ASP A 166
ASP A 189
 SAH  A 258 (-3.4A)
SAH  A 258 (-3.2A)
SAH  A 258 (-3.4A)
SAH  A 258 ( 3.6A)
 1.06A 4uckB-3tosA:
6.6		 4uckB-3tosA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		4 SER A 644
GLY A 488
GLU A 489
ASP A 511
 ADP  A1002 (-2.6A)
None
ADP  A1002 ( 4.6A)
None
 1.02A 4uckB-3ux8A:
undetectable		 4uckB-3ux8A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN
V-TYPE ATP SYNTHASE
BETA CHAIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 GLY D  10
GLU D  22
ASP A  43
ASP D  67
 None
 1.03A 4uckB-3w3aD:
undetectable		 4uckB-3w3aD:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 GLY A 495
ASP A 311
ASP A 241
ASP A 493
 None
 1.00A 4uckB-4c22A:
undetectable		 4uckB-4c22A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		4 SER A 645
GLY A 612
GLU A 637
ASP A 675
 None
 1.03A 4uckB-4ex4A:
undetectable		 4uckB-4ex4A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 SER A 458
GLY A 465
GLU A 464
ASP A 466
 None
 0.92A 4uckB-4fwtA:
undetectable		 4uckB-4fwtA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grx AMINOTRANSFERASE

(Paracoccus
denitrificans) 		PF00202
(Aminotran_3) 		4 GLY A 411
ASP A  43
ASP A  51
ASP A 409
 None
 1.05A 4uckB-4grxA:
undetectable		 4uckB-4grxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i14 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBBA

(Mycobacterium
tuberculosis) 		PF00925
(GTP_cyclohydro2)
PF00926
(DHBP_synthase) 		4 GLY A 143
GLU A 146
ASP A  33
ASP A  25
 SO4  A 502 (-3.2A)
SO4  A 502 (-4.4A)
None
None
 0.89A 4uckB-4i14A:
undetectable		 4uckB-4i14A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 GLY A 487
GLU A 486
ASP A 325
ASP A 259
 None
 0.92A 4uckB-4ia5A:
undetectable		 4uckB-4ia5A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		4 GLY A 561
ASP A 408
ASP A 113
ASP A 554
 None
CA  A 704 (-3.3A)
None
CA  A 705 (-2.8A)
 0.82A 4uckB-4jjjA:
undetectable		 4uckB-4jjjA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAH  A1001 (-2.8A)
SAH  A1001 (-3.3A)
SAH  A1001 (-3.7A)
SAH  A1001 (-3.6A)
 0.73A 4uckB-4k6mA:
9.3		 4uckB-4k6mA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n3n EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5B-LIKE PROTEIN,
EIF5B(517-C)

(Chaetomium
thermophilum) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		4 SER A 861
GLY A 881
GLU A 884
ASP A 930
 None
 1.04A 4uckB-4n3nA:
undetectable		 4uckB-4n3nA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6j LMO0131 PROTEIN

(Listeria
monocytogenes) 		PF00563
(EAL) 		4 GLY A 210
GLU A 209
ASP A 213
ASP A 175
 EDO  A 309 (-3.4A)
None
GOL  A 306 (-3.0A)
None
 1.02A 4uckB-4q6jA:
undetectable		 4uckB-4q6jA:
21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 GLY A1696
ASP A1725
ASP A1755
ASP A1779
 None
 0.69A 4uckB-4uclA:
58.7		 4uckB-4uclA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 GLY A1696
GLU A1697
ASP A1755
ASP A1779
 None
 0.89A 4uckB-4uclA:
58.7		 4uckB-4uclA:
99.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 4 SER A1668
GLY A1696
ASP A1755
ASP A1779
 None
 0.61A 4uckB-4uclA:
58.7		 4uckB-4uclA:
99.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9l PROTEIN ACDH-11,
ISOFORM B

(Caenorhabditis
elegans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		4 GLY A 286
ASP A 108
ASP A 279
ASP A 309
 None
 0.88A 4uckB-4y9lA:
undetectable		 4uckB-4y9lA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo6 LIN1840 PROTEIN

(Listeria
innocua) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 259
GLU A 260
ASP A 264
ASP A 255
 None
 0.85A 4uckB-4zo6A:
undetectable		 4uckB-4zo6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5l D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE

(Thermosynechococcus
elongatus) 		PF03320
(FBPase_glpX) 		4 GLY A  56
GLU A  57
ASP A 129
ASP A  97
 None
MG  A1341 (-2.8A)
None
MG  A1342 (-2.6A)
 0.89A 4uckB-5a5lA:
undetectable		 4uckB-5a5lA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cni METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 GLY A 217
GLU A 218
ASP A 274
ASP A 295
 None
None
None
GGL  A 601 (-3.0A)
 1.06A 4uckB-5cniA:
undetectable		 4uckB-5cniA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9q GENOME POLYPROTEIN

(Dengue virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAM  A 301 (-2.7A)
SAM  A 301 (-3.3A)
SAM  A 301 (-3.4A)
SAM  A 301 (-3.8A)
 0.57A 4uckB-5e9qA:
7.7		 4uckB-5e9qA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exk LIPOYL SYNTHASE

(Mycobacterium
tuberculosis) 		PF04055
(Radical_SAM)
PF16881
(LIAS_N) 		4 GLY A  50
GLU A  49
ASP A  99
ASP A  79
 None
 0.91A 4uckB-5exkA:
undetectable		 4uckB-5exkA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		4 GLY L 190
GLU L 189
ASP L  17
ASP L 192
 None
 0.81A 4uckB-5fmgL:
undetectable		 4uckB-5fmgL:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyd OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Collinsella
aerofaciens) 		PF00106
(adh_short) 		4 GLY A 136
ASP A 134
ASP A  84
ASP A 180
 None
 1.00A 4uckB-5fydA:
4.8		 4uckB-5fydA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gje LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 6

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 GLU B 697
ASP B 673
ASP B 668
ASP B 735
 None
NAG  B1302 ( 4.8A)
None
None
 1.03A 4uckB-5gjeB:
undetectable		 4uckB-5gjeB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvx TREHALOSE-PHOSPHATE
PHOSPHATASE

(Mycobacterium
tuberculosis) 		PF02358
(Trehalose_PPase) 		4 GLY A 205
GLU A 210
ASP A 147
ASP A 188
 None
None
MG  A 401 ( 2.9A)
None
 0.99A 4uckB-5gvxA:
undetectable		 4uckB-5gvxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9u S-ADENOSYLMETHIONINE
SYNTHASE

(Thermus
thermophilus) 		no annotation 4 GLY C 277
GLU C  44
ASP C  22
ASP C  30
 None
 0.96A 4uckB-5h9uC:
undetectable		 4uckB-5h9uC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 GLY A 475
GLU A 173
ASP A 508
ASP A 460
 CL  A 702 ( 3.9A)
GLC  A 712 ( 2.7A)
None
None
 1.05A 4uckB-5hqbA:
undetectable		 4uckB-5hqbA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikm NS5 METHYL
TRANSFERASE

(Dengue virus) 		PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAM  A 311 ( 2.7A)
SAM  A 311 (-3.2A)
MLT  A 313 ( 2.6A)
SAM  A 311 (-3.8A)
 0.57A 4uckB-5ikmA:
9.5		 4uckB-5ikmA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix8 PUTATIVE SUGAR ABC
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN

(Bordetella
parapertussis) 		PF13407
(Peripla_BP_4) 		4 SER A 322
GLY A 200
GLU A 199
ASP A 160
 None
 0.97A 4uckB-5ix8A:
undetectable		 4uckB-5ix8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE

(Streptomyces
sp. MJ635-86F5) 		PF00501
(AMP-binding) 		4 GLY A 365
ASP A 349
ASP A 407
ASP A 352
 None
 1.01A 4uckB-5jjpA:
2.3		 4uckB-5jjpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjr GENOME POLYPROTEIN

(Dengue virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAH  A1003 (-2.7A)
SAH  A1003 (-3.4A)
SAH  A1003 (-3.0A)
SAH  A1003 (-3.8A)
 0.55A 4uckB-5jjrA:
6.3		 4uckB-5jjrA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLY A 603
ASP A 153
ASP A 628
ASP A 600
 None
 1.02A 4uckB-5ju6A:
undetectable		 4uckB-5ju6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 GLY A 140
ASP A 177
ASP A 174
ASP A 142
 None
 0.81A 4uckB-5m7rA:
undetectable		 4uckB-5m7rA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nju GENOME POLYPROTEIN

(Zika virus) 		no annotation 4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAH  A1001 (-2.6A)
SAH  A1001 (-3.4A)
SAH  A1001 (-3.9A)
SAH  A1001 (-3.7A)
 0.76A 4uckB-5njuA:
9.5		 4uckB-5njuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nuq PROBABLE
PHOSPHOLIPID-BINDING
LIPOPROTEIN MLAA

(Serratia
marcescens) 		no annotation 4 GLY G 146
GLU G 145
ASP G 151
ASP G 144
 None
 0.92A 4uckB-5nuqG:
undetectable		 4uckB-5nuqG:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nur ABC TRANSPORTER
PERMEASE

(Klebsiella
pneumoniae) 		no annotation 4 GLY D 147
GLU D 146
ASP D 152
ASP D 145
 None
 1.05A 4uckB-5nurD:
undetectable		 4uckB-5nurD:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oas MALATE SYNTHASE G

(Pseudomonas
aeruginosa) 		no annotation 4 SER A 638
GLY A 605
GLU A 630
ASP A 668
 None
 1.06A 4uckB-5oasA:
undetectable		 4uckB-5oasA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ov3 RETINOBLASTOMA-BINDI
NG PROTEIN 5

(Mus musculus) 		no annotation 4 GLY A  57
ASP A 340
ASP A  22
ASP A  52
 None
 1.05A 4uckB-5ov3A:
undetectable		 4uckB-5ov3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 SER A  56
GLY A  81
ASP A 131
ASP A 146
 SAH  A1001 (-2.5A)
SAH  A1001 (-3.4A)
SAH  A1001 (-4.0A)
SAH  A1001 (-3.8A)
 0.62A 4uckB-5tmhA:
9.8		 4uckB-5tmhA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj6 GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN
PROTEIN

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF11721
(Malectin)
PF16355
(DUF4982) 		4 GLY A 771
ASP A 532
ASP A 584
ASP A 770
 None
None
None
GOL  A 903 ( 3.2A)
 0.98A 4uckB-5uj6A:
undetectable		 4uckB-5uj6A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xq5 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		no annotation 4 GLY A  20
GLU A  19
ASP A  35
ASP A  64
 None
 1.04A 4uckB-5xq5A:
undetectable		 4uckB-5xq5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		4 SER A 644
GLY A 611
GLU A 636
ASP A 674
 None
 1.02A 4uckB-6axeA:
undetectable		 4uckB-6axeA:
19.89