SIMILAR PATTERNS OF AMINO ACIDS FOR 4UCI_A_SAMA2409_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d6s | O-ACETYLSERINESULFHYDRYLASE (Salmonellaenterica) |
PF00291(PALP) | 5 | GLY A 174GLY A 179ASN A 237SER A 173ALA A 275 | NonePLP A 501 (-3.9A)NoneNoneNone | 1.02A | 4uciA-1d6sA:undetectable | 4uciA-1d6sA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g68 | BETA-LACTAMASE PSE-4 (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 5 | THR A 69GLY A 242GLY A 240GLY A 172ALA A 270 | None | 0.82A | 4uciA-1g68A:undetectable | 4uciA-1g68A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h74 | HOMOSERINE KINASE (Methanocaldococcusjannaschii) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | THR A 183GLY A 96GLY A 94GLY A 92ALA A 145 | ADP A 400 ( 3.1A)ADP A 400 ( 4.0A)ADP A 400 ( 4.5A)ADP A 400 (-3.7A)None | 1.00A | 4uciA-1h74A:undetectable | 4uciA-1h74A:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kbl | PYRUVATE PHOSPHATEDIKINASE ([Clostridium]symbiosum) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | GLY A 254GLY A 252GLY A 245ASN A 246ALA A 256 | None | 1.00A | 4uciA-1kblA:undetectable | 4uciA-1kblA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcz | BETA-METHYLASPARTASE (Clostridiumtetanomorphum) |
PF05034(MAAL_N)PF07476(MAAL_C) | 5 | GLY A 394GLY A 388GLY A 14ASN A 362ALA A 385 | NoneOCS A 361 ( 3.5A)OCS A 361 ( 3.4A)NoneNone | 1.01A | 4uciA-1kczA:undetectable | 4uciA-1kczA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74GLY A 76LEU A 95ALA A 138 | SAH A1900 (-3.1A)SAH A1900 (-3.2A)NoneSAH A1900 (-4.4A)SAH A1900 (-3.2A) | 0.96A | 4uciA-1kphA:6.6 | 4uciA-1kphA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwg | BETA-GALACTOSIDASE (Thermusthermophilus) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | GLY A 482TRP A 570SER A 485LEU A 461ALA A 408 | None | 0.99A | 4uciA-1kwgA:undetectable | 4uciA-1kwgA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1e | MYCOLIC ACIDSYNTHASE (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74GLY A 76LEU A 95ALA A 138 | SAH A 900 (-3.1A)SAH A 900 (-3.4A)NoneSAH A 900 (-4.1A)SAH A 900 (-3.4A) | 0.89A | 4uciA-1l1eA:6.8 | 4uciA-1l1eA:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l3i | PRECORRIN-6YMETHYLTRANSFERASE/PUTATIVE DECARBOXYLASE (Methanothermobacterthermautotrophicus) |
PF13847(Methyltransf_31) | 5 | THR A 17GLY A 41GLY A 43GLY A 45ALA A 91 | SAH A 801 (-3.7A)SAH A 801 (-3.4A)SAH A 801 (-3.2A)SAH A 801 (-4.0A)SAH A 801 (-3.2A) | 0.58A | 4uciA-1l3iA:8.4 | 4uciA-1l3iA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lml | LEISHMANOLYSIN (Leishmaniamajor) |
PF01457(Peptidase_M8) | 5 | GLY A 352GLY A 567ASN A 568ALA A 346ALA A 350 | None | 0.96A | 4uciA-1lmlA:undetectable | 4uciA-1lmlA:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lnz | SPO0B-ASSOCIATEDGTP-BINDING PROTEIN (Bacillussubtilis) |
PF01018(GTP1_OBG)PF01926(MMR_HSR1) | 5 | GLY A 41GLY A 16GLY A 123ALA A 66ALA A 82 | None | 0.95A | 4uciA-1lnzA:undetectable | 4uciA-1lnzA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qle | CYTOCHROME C OXIDASEPOLYPEPTIDE I-BETA (Paracoccusdenitrificans) |
PF00115(COX1) | 6 | GLY A 153GLU A 174GLY A 159GLY A 161ASN A 88SER A 178 | None | 1.33A | 4uciA-1qleA:undetectable | 4uciA-1qleA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rjw | ALCOHOLDEHYDROGENASE (Geobacillusstearothermophilus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | THR A 306GLY A 177GLY A 175GLY A 330ALA A 180 | None | 0.99A | 4uciA-1rjwA:3.7 | 4uciA-1rjwA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rkx | CDP-GLUCOSE-4,6-DEHYDRATASE (Yersiniapseudotuberculosis) |
PF16363(GDP_Man_Dehyd) | 5 | GLY A 16GLY A 19GLY A 23LEU A 41ALA A 88 | NAD A 360 (-3.4A)NAD A 360 (-3.3A)NoneNAD A 360 (-4.1A)NAD A 360 (-3.6A) | 0.81A | 4uciA-1rkxA:4.2 | 4uciA-1rkxA:21.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sgv | TRNA PSEUDOURIDINESYNTHASE B (Mycobacteriumtuberculosis) |
PF01509(TruB_N)PF09142(TruB_C)PF16198(TruB_C_2) | 5 | THR A 32GLY A 7GLY A 5ALA A 231ALA A 56 | None | 0.76A | 4uciA-1sgvA:undetectable | 4uciA-1sgvA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sus | CAFFEOYL-COAO-METHYLTRANSFERASE (Medicago sativa) |
PF01596(Methyltransf_3) | 5 | THR A 63GLY A 87GLY A 91ALA A 140ALA A 164 | SAH A 301 ( 2.8A)SAH A 301 (-3.4A)NoneSAH A 301 (-3.9A)SAH A 301 ( 3.7A) | 0.82A | 4uciA-1susA:7.9 | 4uciA-1susA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tpy | METHOXY MYCOLIC ACIDSYNTHASE 2 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 72GLY A 74GLY A 76LEU A 95ALA A 138 | SAH A1900 (-3.2A)SAH A1900 (-3.3A)NoneSAH A1900 (-4.3A)SAH A1900 (-3.1A) | 0.93A | 4uciA-1tpyA:6.3 | 4uciA-1tpyA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulq | PUTATIVE ACETYL-COAACETYLTRANSFERASE (Thermusthermophilus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | GLY A 115GLY A 359ASN A 57ALA A 261ALA A 259 | None | 0.99A | 4uciA-1ulqA:undetectable | 4uciA-1ulqA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fca | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Bacillussubtilis) |
PF02390(Methyltransf_4) | 5 | GLY A 46GLY A 48GLY A 50LEU A 70ALA A 97 | K A 250 (-3.9A)NoneNoneNoneNone | 0.96A | 4uciA-2fcaA:6.7 | 4uciA-2fcaA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fk7 | METHOXY MYCOLIC ACIDSYNTHASE 4 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | GLY A 81GLY A 83GLY A 85LEU A 104ALA A 147 | None | 1.00A | 4uciA-2fk7A:6.2 | 4uciA-2fk7A:25.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gd2 | PROBABLEALPHA-METHYLACYL-COARACEMASE MCR (Mycobacteriumtuberculosis) |
PF02515(CoA_transf_3) | 5 | GLY A 219GLY A 213GLY A 143LEU A 217ALA A 221 | None | 0.93A | 4uciA-2gd2A:2.0 | 4uciA-2gd2A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hyp | HYPOTHETICAL PROTEINRV0805 (Mycobacteriumtuberculosis) |
PF00149(Metallophos) | 5 | THR A 134GLY A 206GLY A 62GLY A 96SER A 20 | None | 0.98A | 4uciA-2hypA:undetectable | 4uciA-2hypA:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0k | OXIDOREDUCTASE (Brevibacteriumsterolicum) |
PF01565(FAD_binding_4)PF09129(Chol_subst-bind) | 5 | THR A 500GLY A 203GLY A 480LEU A 185ALA A 187 | NoneNoneNoneNoneFAD A 700 (-3.5A) | 0.91A | 4uciA-2i0kA:undetectable | 4uciA-2i0kA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r66 | GLYCOSYLTRANSFERASE, GROUP 1 (Halothermothrixorenii) |
PF00534(Glycos_transf_1)PF00862(Sucrose_synth) | 6 | THR A 388GLY A 372GLY A 392GLY A 391ASN A 390ALA A 374 | None | 1.31A | 4uciA-2r66A:2.2 | 4uciA-2r66A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdv | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Saccharomycescerevisiae) |
PF02390(Methyltransf_4) | 5 | THR E 259GLY E 103GLY E 105GLY E 107ALA E 162 | SAM E1287 (-2.8A)SAM E1287 (-3.1A)SAM E1287 (-3.6A)NoneSAM E1287 (-3.9A) | 0.78A | 4uciA-2vdvE:4.8 | 4uciA-2vdvE:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wa2 | NON-STRUCTURALPROTEIN 5 (Modoc virus) |
PF01728(FtsJ) | 5 | GLY A 82GLY A 84GLY A 86LEU A 106LYS A 184 | SAM A1248 (-3.3A)SAM A1248 (-3.4A)SAM A1248 (-4.4A)SAM A1248 (-4.1A)None | 0.78A | 4uciA-2wa2A:9.7 | 4uciA-2wa2A:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yys | PROLINEIMINOPEPTIDASE-RELATED PROTEIN (Thermusthermophilus) |
PF12697(Abhydrolase_6) | 6 | GLY A 62GLY A 64GLY A 37SER A 66LEU A 67ALA A 13 | None | 1.44A | 4uciA-2yysA:undetectable | 4uciA-2yysA:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bga | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 5 | GLY A 945GLY A 943GLY A1024LEU A 938LYS A 775 | None | 0.90A | 4uciA-3bgaA:undetectable | 4uciA-3bgaA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bmw | CYCLOMALTODEXTRINGLUCANOTRANSFERASE (Thermoanaerobacteriumthermosulfurigenes) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG) | 5 | GLY A 485GLU A 486GLY A 466ASN A 467ALA A 484 | None | 0.92A | 4uciA-3bmwA:undetectable | 4uciA-3bmwA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bus | METHYLTRANSFERASE (Lechevalieriaaerocolonigenes) |
PF08241(Methyltransf_11) | 5 | GLY A 69GLY A 71GLY A 73SER A 91ALA A 120 | SAH A 274 (-3.1A)SAH A 274 (-3.4A)NoneSAH A 274 (-3.0A)SAH A 274 (-3.5A) | 0.85A | 4uciA-3busA:7.3 | 4uciA-3busA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c3y | O-METHYLTRANSFERASE (Mesembryanthemumcrystallinum) |
PF01596(Methyltransf_3) | 5 | THR A 54GLY A 78GLY A 82ALA A 131ALA A 155 | SAH A 464 (-3.5A)SAH A 464 (-3.7A)SAH A 464 ( 4.6A)SAH A 464 (-3.5A)SAH A 464 (-3.7A) | 0.83A | 4uciA-3c3yA:8.2 | 4uciA-3c3yA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ckk | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Homo sapiens) |
PF02390(Methyltransf_4) | 5 | THR A 208GLY A 54GLY A 56GLY A 58ALA A 111 | SAM A 301 (-2.8A)GOL A 302 ( 3.3A)SAM A 301 (-3.5A)NoneSAM A 301 (-3.7A) | 0.95A | 4uciA-3ckkA:5.4 | 4uciA-3ckkA:18.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dou | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE J (Thermoplasmavolcanium) |
PF01728(FtsJ) | 5 | GLY A 46GLY A 50LEU A 68ALA A 112LYS A 151 | SAM A 1 (-3.5A)SAM A 1 (-3.8A)SAM A 1 (-4.2A)SAM A 1 (-3.7A)SAM A 1 (-3.5A) | 0.58A | 4uciA-3douA:8.8 | 4uciA-3douA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3elu | METHYLTRANSFERASE (Wesselsbronvirus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 5 | GLY A 81GLY A 83GLY A 85LEU A 105LYS A 182 | SAM A4633 (-3.2A)SAM A4633 (-3.4A)SAM A4633 ( 4.3A)SAM A4633 (-4.1A)None | 0.83A | 4uciA-3eluA:9.5 | 4uciA-3eluA:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3evc | RNA-DIRECTED RNAPOLYMERASE NS5 (Yellow fevervirus) |
PF01728(FtsJ) | 5 | GLY A 81GLY A 83GLY A 85LEU A 105LYS A 182 | SAH A 901 (-3.4A)SAH A 901 (-3.3A)SAH A 901 ( 4.4A)SAH A 901 (-4.0A)None | 0.87A | 4uciA-3evcA:9.0 | 4uciA-3evcA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6r | FLAVODOXIN (Desulfovibriodesulfuricans) |
PF00258(Flavodoxin_1) | 5 | GLY A 94GLU A 127GLY A 128SER A 93ALA A 59 | FMN A 149 (-2.9A)NoneNoneFMN A 149 (-3.8A)FMN A 149 (-3.7A) | 0.81A | 4uciA-3f6rA:undetectable | 4uciA-3f6rA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g1w | SUGAR ABCTRANSPORTER (Bacillushalodurans) |
PF13407(Peripla_BP_4) | 5 | GLY A 241GLY A 239GLY A 236ASN A 235ALA A 250 | None | 1.01A | 4uciA-3g1wA:undetectable | 4uciA-3g1wA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gcz | POLYPROTEIN (Yokose virus) |
PF01728(FtsJ) | 5 | GLY A 81GLY A 83GLY A 85LEU A 105LYS A 183 | SAM A4633 (-3.4A)SAM A4633 (-3.4A)SAM A4633 ( 4.3A)SAM A4633 (-4.0A)SAM A4633 ( 4.8A) | 0.92A | 4uciA-3gczA:10.1 | 4uciA-3gczA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gms | PUTATIVENADPH:QUINONEREDUCTASE (Bacillusthuringiensis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 245GLY A 221ASN A 249SER A 244LEU A 243 | None | 0.95A | 4uciA-3gmsA:3.9 | 4uciA-3gmsA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hd6 | AMMONIUM TRANSPORTERRH TYPE C (Homo sapiens) |
PF00909(Ammonium_transp) | 6 | THR A 401GLY A 345GLY A 348GLY A 352LEU A 343ALA A 189 | None | 1.41A | 4uciA-3hd6A:undetectable | 4uciA-3hd6A:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ib7 | ICC PROTEIN (Mycobacteriumtuberculosis) |
PF00149(Metallophos) | 5 | THR A 134GLY A 206GLY A 62GLY A 96SER A 20 | None | 1.00A | 4uciA-3ib7A:undetectable | 4uciA-3ib7A:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3igz | COFACTOR-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Leishmaniamexicana) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | GLY B 199GLY B 220SER B 198ALA B 235ALA B 161 | None | 0.80A | 4uciA-3igzB:3.9 | 4uciA-3igzB:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihs | PHOSPHOCARRIERPROTEIN HPR (Bacillusanthracis) |
PF00381(PTS-HPr) | 5 | GLY A 58GLY A 56GLY A 13ASN A 12SER A 59 | None | 0.88A | 4uciA-3ihsA:undetectable | 4uciA-3ihsA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwa | FAD-DEPENDENTPYRIDINENUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE (Desulfovibriovulgaris) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 6 | GLY A 14GLY A 318GLY A 322ASN A 324ALA A 10ALA A 119 | None | 1.22A | 4uciA-3iwaA:undetectable | 4uciA-3iwaA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j09 | COPPER-EXPORTINGP-TYPE ATPASE A (Archaeoglobusfulgidus) |
PF00122(E1-E2_ATPase)PF00403(HMA)PF00702(Hydrolase) | 5 | GLY A 619GLY A 617GLY A 427ALA A 215ALA A 623 | None | 0.92A | 4uciA-3j09A:undetectable | 4uciA-3j09A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kaq | FLAVODOXIN (Desulfovibriodesulfuricans) |
PF00258(Flavodoxin_1) | 5 | GLY A 94GLU A 127GLY A 128SER A 93ALA A 59 | FMN A 150 (-3.3A)NoneNoneFMN A 150 (-3.8A)FMN A 150 (-3.6A) | 0.82A | 4uciA-3kaqA:undetectable | 4uciA-3kaqA:14.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdu | N-FORMIMINO-L-GLUTAMATE IMINOHYDROLASE (Pseudomonasaeruginosa) |
PF01979(Amidohydro_1) | 5 | GLY A 367GLY A 316GLY A 289LEU A 365ALA A 369 | None | 0.95A | 4uciA-3mduA:undetectable | 4uciA-3mduA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mkh | NITROALKANE OXIDASE (Podosporaanserina) |
PF00441(Acyl-CoA_dh_1)PF02771(Acyl-CoA_dh_N) | 5 | GLY A 278GLY A 281GLY A 283ALA A 274ALA A 355 | None | 1.01A | 4uciA-3mkhA:undetectable | 4uciA-3mkhA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq2 | 16S RRNAMETHYLTRANSFERASE (Streptoalloteichustenebrarius) |
PF02390(Methyltransf_4) | 5 | THR A 191GLY A 32GLY A 34GLY A 36ALA A 87 | SAH A 216 (-2.7A)SAH A 216 (-3.5A)SAH A 216 (-3.4A)NoneSAH A 216 (-3.5A) | 0.61A | 4uciA-3mq2A:6.2 | 4uciA-3mq2A:19.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3njr | PRECORRIN-6YMETHYLASE (Rhodobactercapsulatus) |
no annotation | 5 | THR A 18GLY A 42GLY A 44GLY A 46ALA A 92 | SAH A 300 (-3.8A)SAH A 300 (-3.1A)SAH A 300 (-3.4A)SAH A 300 (-4.6A)SAH A 300 (-4.2A) | 0.97A | 4uciA-3njrA:7.8 | 4uciA-3njrA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvl | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Trypanosomabrucei) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 5 | GLY A 198GLY A 219SER A 197ALA A 234ALA A 160 | None | 0.92A | 4uciA-3nvlA:3.7 | 4uciA-3nvlA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qsl | PUTATIVE EXPORTEDPROTEIN (Bordetellabronchiseptica) |
PF13379(NMT1_2) | 6 | THR A 194GLY A 91GLY A 40GLY A 41LEU A 78ALA A 92 | CIT A 347 ( 4.3A)CIT A 347 (-3.4A)CIT A 347 (-3.8A)NoneNoneCIT A 347 (-3.6A) | 1.25A | 4uciA-3qslA:undetectable | 4uciA-3qslA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r8r | TRANSALDOLASE (Bacillussubtilis) |
PF00923(TAL_FSA) | 5 | THR A 26GLY A 183GLY A 24ALA A 175ALA A 163 | GOL A 221 ( 4.8A)NoneNoneNoneNone | 1.02A | 4uciA-3r8rA:undetectable | 4uciA-3r8rA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT N (Escherichiacoli) |
no annotation | 5 | GLY N 385GLY N 391GLY N 394LEU N 381ALA N 384 | None | 0.93A | 4uciA-3rkoN:undetectable | 4uciA-3rkoN:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr6 | O-METHYLTRANSFERASE (Coxiellaburnetii) |
PF01596(Methyltransf_3) | 5 | THR A 45GLY A 69GLY A 73ALA A 122ALA A 145 | SAH A 224 (-3.6A)SAH A 224 (-3.9A)NoneSAH A 224 (-3.8A)SAH A 224 (-3.5A) | 0.94A | 4uciA-3tr6A:7.8 | 4uciA-3tr6A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uav | PURINE NUCLEOSIDEPHOSPHORYLASEDEOD-TYPE (Bacillus cereus) |
PF01048(PNP_UDP_1) | 5 | GLY A 65GLU A 181GLY A 63GLY A 20SER A 68 | NoneSO4 A 236 ( 4.4A)NoneSO4 A 236 (-3.3A)None | 1.00A | 4uciA-3uavA:undetectable | 4uciA-3uavA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ugk | SACCHAROPINEDEHYDROGENASE [NAD+,L-LYSINE-FORMING] (Saccharomycescerevisiae) |
PF05222(AlaDh_PNT_N) | 5 | GLY A 140GLY A 206GLY A 203LEU A 212ALA A 142 | None | 0.96A | 4uciA-3ugkA:undetectable | 4uciA-3ugkA:23.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ure | ALPHA-LYTIC PROTEASE (Lysobacterenzymogenes) |
PF00089(Trypsin) | 5 | GLY A 197GLY A 140ASN A 120SER A 43ALA A 55 | None | 1.02A | 4uciA-3ureA:undetectable | 4uciA-3ureA:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vr0 | PUTATIVEUNCHARACTERIZEDPROTEIN (Pyrococcusfuriosus) |
PF09754(PAC2) | 5 | GLY A 43GLY A 139GLY A 209LEU A 36ALA A 47 | None AU A 304 ( 3.7A)NoneNoneNone | 0.95A | 4uciA-3vr0A:undetectable | 4uciA-3vr0A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a7k | ALDOS-2-ULOSEDEHYDRATASE (Phanerochaetechrysosporium) |
no annotation | 5 | GLY A 271GLY A 241GLY A 258LEU A 213ALA A 293 | None | 0.94A | 4uciA-4a7kA:undetectable | 4uciA-4a7kA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btg | MAJOR INNER PROTEINP1 (Pseudomonasvirus phi6) |
no annotation | 5 | GLY A 687GLY A 682GLY A 728TRP A 726ALA A 688 | None | 0.91A | 4uciA-4btgA:undetectable | 4uciA-4btgA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c7v | TRANSKETOLASE (Lactobacillussalivarius) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 6 | THR A 427GLY A 128GLY A 420TRP A 375ALA A 173ALA A 130 | None | 1.36A | 4uciA-4c7vA:2.8 | 4uciA-4c7vA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cp8 | ALLOPHANATEHYDROLASE (Pseudomonas sp.ADP) |
PF01425(Amidase) | 5 | THR A 390GLY A 190GLY A 188SER A 225ALA A 238 | NoneNoneMLI A1466 (-4.0A)NoneNone | 0.86A | 4uciA-4cp8A:undetectable | 4uciA-4cp8A:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fnq | ALPHA-GALACTOSIDASEAGAB (Geobacillusstearothermophilus) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 5 | GLY A 531GLU A 202GLY A 529ASN A 549ALA A 223 | None | 0.97A | 4uciA-4fnqA:undetectable | 4uciA-4fnqA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gbf | PHIKZ131 (Pseudomonasvirus phiKZ) |
no annotation | 6 | THR A 562GLY A 727GLY A 687GLY A 619ASN A 561ALA A 413 | None | 1.50A | 4uciA-4gbfA:undetectable | 4uciA-4gbfA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hsu | LYSINE-SPECIFICHISTONE DEMETHYLASE1B (Homo sapiens) |
PF01593(Amino_oxidase)PF04433(SWIRM)PF07496(zf-CW) | 5 | GLY A 812GLY A 794SER A 811LEU A 810ALA A 396 | NoneFAD A 901 (-3.2A)NoneNoneNone | 0.86A | 4uciA-4hsuA:undetectable | 4uciA-4hsuA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4htf | S-ADENOSYLMETHIONINE-DEPENDENTMETHYLTRANSFERASE (Escherichiacoli) |
PF13847(Methyltransf_31) | 5 | GLY B 52GLY B 54GLY B 56LEU B 74ALA B 102 | SAM B 301 (-3.5A)SAM B 301 (-3.4A)NoneSAM B 301 (-4.2A)SAM B 301 (-3.7A) | 0.57A | 4uciA-4htfB:8.6 | 4uciA-4htfB:25.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3u | ALDEHYDEDEHYDROGENASE (NAD+) (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 5 | GLY A 460GLY A 256GLY A 257ASN A 258LEU A 253 | None | 0.98A | 4uciA-4i3uA:undetectable | 4uciA-4i3uA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i59 | CYCLOHEXYLAMINEOXIDASE (Microbacteriumoxydans) |
PF01593(Amino_oxidase) | 5 | GLY A 421GLY A 201GLY A 371ASN A 373ALA A 418 | None | 0.84A | 4uciA-4i59A:undetectable | 4uciA-4i59A:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iit | PHENYLACETATE-COAOXYGENASE SUBUNITPAAC (Klebsiellapneumoniae) |
PF05138(PaaA_PaaC) | 5 | GLY C 210GLY C 148GLY C 150SER C 209LEU C 206 | None | 0.87A | 4uciA-4iitC:undetectable | 4uciA-4iitC:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | GLY A 232GLY A 234GLY A 236LEU A 255ALA A 282 | SAH A 501 (-3.6A)SAH A 501 (-3.6A)NoneSAH A 501 (-4.3A)SAH A 501 (-3.6A) | 0.81A | 4uciA-4ineA:6.8 | 4uciA-4ineA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 6 | GLY A 228GLY A 230GLY A 232ASN A 198LEU A 251ALA A 278 | SAH A 701 (-3.5A)SAH A 701 (-3.5A)NoneNoneSAH A 701 (-4.4A)SAH A 701 (-3.7A) | 1.45A | 4uciA-4kriA:7.1 | 4uciA-4kriA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ks9 | MALONYL-COADECARBOXYLASE (Cupriavidusmetallidurans) |
PF05292(MCD)PF17408(MCD_N) | 5 | GLY A 400GLY A 403GLY A 461ASN A 462ALA A 406 | None | 0.97A | 4uciA-4ks9A:undetectable | 4uciA-4ks9A:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nd4 | LACTATEDEHYDROGENASE,ADJACENT GENEENCODES PREDICTEDMALATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | GLY A 28GLY A 30GLY A 34ASN A 35ALA A 98 | NAD A 401 ( 3.9A)NAD A 401 (-3.3A)NoneNoneNAD A 401 (-3.5A) | 1.01A | 4uciA-4nd4A:undetectable | 4uciA-4nd4A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nec | PUTATIVESAM-DEPENDENTMETHYLTRANSFERASE (Streptomyceslasaliensis) |
PF13649(Methyltransf_25) | 5 | GLY A 47GLY A 49GLY A 51LEU A 69ALA A 95 | SAH A 401 (-3.9A)SAH A 401 (-3.6A)NoneSAH A 401 (-3.7A)SAH A 401 (-3.2A) | 0.60A | 4uciA-4necA:7.1 | 4uciA-4necA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pfw | ABC TRANSPORTERSUBSTRATE-BINDINGPROTEIN (Thermotogamaritima) |
PF00496(SBP_bac_5) | 5 | GLY A 279ASN A 432LEU A 317ALA A 315ALA A 515 | None | 1.00A | 4uciA-4pfwA:undetectable | 4uciA-4pfwA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r2w | URIDINEPHOSPHORYLASE (Shewanellaoneidensis) |
PF01048(PNP_UDP_1) | 6 | GLY A 67GLU A 195GLY A 65GLY A 23SER A 70ALA A 116 | NoneGOL A 303 (-2.9A)NoneSO4 A 302 (-3.2A)NoneNone | 1.30A | 4uciA-4r2wA:undetectable | 4uciA-4r2wA:20.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ucl | RNA-DIRECTED RNAPOLYMERASE L (Humanmetapneumovirus) |
no annotation | 10 | GLY A1696GLU A1697GLY A1698GLY A1700ASN A1701TRP A1702LEU A1720ALA A1756ALA A1780LYS A1817 | None | 0.94A | 4uciA-4uclA:58.4 | 4uciA-4uclA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ucl | RNA-DIRECTED RNAPOLYMERASE L (Humanmetapneumovirus) |
no annotation | 9 | GLY A1696GLU A1697GLY A1698GLY A1700ASN A1701TRP A1702SER A1719LEU A1720ALA A1756 | None | 1.16A | 4uciA-4uclA:58.4 | 4uciA-4uclA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ucl | RNA-DIRECTED RNAPOLYMERASE L (Humanmetapneumovirus) |
no annotation | 10 | THR A1670GLY A1696GLY A1698GLY A1700ASN A1701TRP A1702LEU A1720ALA A1756ALA A1780LYS A1817 | None | 0.58A | 4uciA-4uclA:58.4 | 4uciA-4uclA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ucl | RNA-DIRECTED RNAPOLYMERASE L (Humanmetapneumovirus) |
no annotation | 9 | THR A1670GLY A1696GLY A1698GLY A1700ASN A1701TRP A1702SER A1719LEU A1720ALA A1756 | None | 0.83A | 4uciA-4uclA:58.4 | 4uciA-4uclA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um8 | INTEGRIN ALPHA-V (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | GLY A 175GLY A 173GLY A 223SER A 176ALA A 149 | None | 0.92A | 4uciA-4um8A:undetectable | 4uciA-4um8A:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgx | MOLINATE HYDROLASE (Gulosibactermolinativorax) |
PF01979(Amidohydro_1) | 5 | THR A 341GLY A 391GLY A 65ASN A 66LEU A 389 | NoneNoneNoneMPD A 502 ( 4.7A)None | 0.98A | 4uciA-4wgxA:undetectable | 4uciA-4wgxA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wk4 | INTEGRIN ALPHA-5 (Homo sapiens) |
PF01839(FG-GAP) | 5 | GLY A 184GLY A 182GLY A 232SER A 185ALA A 158 | None | 0.94A | 4uciA-4wk4A:undetectable | 4uciA-4wk4A:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | GLY A 44GLY A 46GLY A 48LEU A 67ALA A 95 | SAH A 301 (-3.6A)SAH A 301 (-3.4A)NoneSAH A 301 (-3.8A)SAH A 301 (-3.6A) | 0.94A | 4uciA-5epeA:5.7 | 4uciA-5epeA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epe | SAM-DEPENDENTMETHYLTRANSFERASE (Thiobacillusdenitrificans) |
PF13847(Methyltransf_31) | 5 | GLY A 44GLY A 46LEU A 67ALA A 95ALA A 112 | SAH A 301 (-3.6A)SAH A 301 (-3.4A)SAH A 301 (-3.8A)SAH A 301 (-3.6A)SAH A 301 ( 3.7A) | 1.01A | 4uciA-5epeA:5.7 | 4uciA-5epeA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fcr | COMPLEMENT FACTOR D (Mus musculus) |
PF00089(Trypsin) | 5 | GLY A 43GLY A 140GLY A 142SER A 197ALA A 31 | None | 0.94A | 4uciA-5fcrA:undetectable | 4uciA-5fcrA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kva | CAFFEOYL-COAO-METHYLTRANSFERASE (Sorghum bicolor) |
PF01596(Methyltransf_3) | 5 | THR A 77GLY A 101GLY A 105ALA A 154ALA A 178 | SAM A 301 (-3.5A)SAM A 301 (-3.4A)SAM A 301 ( 4.8A)SAM A 301 (-3.7A)SAM A 301 (-3.7A) | 0.91A | 4uciA-5kvaA:8.3 | 4uciA-5kvaA:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lhv | URIDINEPHOSPHORYLASE (Vibrio cholerae) |
PF01048(PNP_UDP_1) | 6 | GLY A 69GLU A 197GLY A 67GLY A 25SER A 72ALA A 118 | NoneURI A 303 (-2.7A) NA A 307 ( 4.0A)SO4 A 301 (-3.3A) NA A 307 (-2.9A)None | 1.32A | 4uciA-5lhvA:undetectable | 4uciA-5lhvA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5log | PUTATIVEO-METHYLTRANSFERASE (Myxococcusxanthus) |
PF01596(Methyltransf_3) | 5 | GLY A 67GLY A 71LEU A 92ALA A 120ALA A 143 | SAH A1001 (-3.5A)NoneSAH A1001 (-4.1A)SAH A1001 (-3.4A)SAH A1001 (-3.7A) | 0.74A | 4uciA-5logA:7.7 | 4uciA-5logA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5min | QUINOPROTEIN GLUCOSEDEHYDROGENASE B (Acinetobactercalcoaceticus) |
no annotation | 5 | GLY A 81GLY A 98GLY A 78ASN A 77ALA A 83 | None | 0.90A | 4uciA-5minA:undetectable | 4uciA-5minA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ny0 | L. REUTERIS SRRPBINDING REGION (Lactobacillusreuteri) |
no annotation | 5 | GLY A 347GLY A 319ASN A 318ALA A 447ALA A 408 | None | 0.94A | 4uciA-5ny0A:undetectable | 4uciA-5ny0A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v6c | HEMOLYSIN-RELATEDPROTEIN (Vibrio cholerae) |
no annotation | 5 | THR A 831GLY A 827GLY A 952SER A 891ALA A 922 | None | 0.97A | 4uciA-5v6cA:undetectable | 4uciA-5v6cA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wuf | PUTATIVE MEMBRANEPROTEIN (Colwelliapsychrerythraea) |
PF03458(UPF0126) | 5 | GLY A 20GLY A 132SER A 19LEU A 18ALA A 38 | None | 0.86A | 4uciA-5wufA:undetectable | 4uciA-5wufA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x6a | ENDOGLUCANASE,PUTATIVE (Aspergillusfumigatus) |
no annotation | 5 | THR A 80GLY A 16GLY A 6TRP A 79ALA A 60 | None | 0.97A | 4uciA-5x6aA:undetectable | 4uciA-5x6aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7f | PUTATIVEO-METHYLTRANSFERASERV1220C (Mycobacteriumtuberculosis) |
PF01596(Methyltransf_3) | 5 | GLY A 66GLY A 68GLY A 70ALA A 120ALA A 139 | SAM A 301 (-3.5A)SAM A 301 (-3.4A)SAM A 301 ( 4.5A)SAM A 301 (-3.5A)SAM A 301 (-3.5A) | 0.60A | 4uciA-5x7fA:7.2 | 4uciA-5x7fA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xww | AMPHB (Streptomycesnodosus) |
no annotation | 5 | GLY A 225GLY A 228GLY A 232ALA A 280ALA A 306 | NAP A 501 (-3.6A)NAP A 501 (-3.2A)NoneNAP A 501 (-3.6A)NAP A 501 (-3.5A) | 0.90A | 4uciA-5xwwA:5.9 | 4uciA-5xwwA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq6 | THERMOSPERMINESYNTHASE (Medicagotruncatula) |
no annotation | 5 | GLY A 110GLU A 109GLY A 108ALA A 148ALA A 113 | CL A 401 (-3.5A)None CL A 401 (-4.6A)None CL A 401 (-3.8A) | 0.96A | 4uciA-6bq6A:6.8 | 4uciA-6bq6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6epe | PROTEASOME SUBUNITBETA TYPE-1 (Rattusnorvegicus) |
no annotation | 5 | GLY 6 113GLU 6 143GLY 6 144GLY 6 146ALA 6 116 | None | 1.00A | 4uciA-6epe6:undetectable | 4uciA-6epe6:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6et9 | ACETYL-COAACETYLTRANSFERASETHIOLASE (Methanothermococcusthermolithotrophicus) |
no annotation | 6 | GLY A 342GLY A 88GLY A 50ASN A 51SER A 89ALA A 373 | None | 1.47A | 4uciA-6et9A:undetectable | 4uciA-6et9A:undetectable |