SIMILAR PATTERNS OF AMINO ACIDS FOR 4UCI_A_ADNA2414

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 GLU A 169
PHE A 147
ARG A 242
HIS A 294
 None
 1.43A 4uciA-1ewrA:
0.0		 4uciA-1ewrA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n60 CARBON MONOXIDE
DEHYDROGENASE LARGE
CHAIN

(Oligotropha
carboxidovorans) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLU B 400
PHE B 486
PHE B 659
TYR B 443
 None
 1.14A 4uciA-1n60B:
0.3		 4uciA-1n60B:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 GLU A 371
PHE A 505
PHE A 444
HIS A 509
 None
 1.22A 4uciA-1opkA:
0.0		 4uciA-1opkA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqg METHIONYL-TRNA
SYNTHETASE

(Pyrococcus
abyssi) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 GLU A 256
PHE A 255
PHE A 107
HIS A 100
 None
 1.49A 4uciA-1rqgA:
1.6		 4uciA-1rqgA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tk1 COPROPORPHYRINOGEN
III OXIDASE

(Saccharomyces
cerevisiae) 		PF01218
(Coprogen_oxidas) 		4 PHE A 212
ARG A 188
PHE A 213
TYR A 216
 None
 1.28A 4uciA-1tk1A:
0.0		 4uciA-1tk1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 34KDA
SUBUNIT

(Bos taurus) 		PF04045
(P34-Arc) 		4 GLU D 150
PHE D 165
PHE D 247
HIS D 252
 None
 1.37A 4uciA-1u2vD:
0.0		 4uciA-1u2vD:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2q SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF00018
(SH3_1) 		4 PHE A  36
PHE A  68
TYR A  24
HIS A  38
 None
 1.38A 4uciA-1x2qA:
undetectable		 4uciA-1x2qA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xof BBAHETT1

() 		no annotation 4 GLU A 113
PHE B 212
ARG B 217
TYR A 101
 DAL  A 109 ( 4.1A)
None
None
DBZ  B 220 ( 3.6A)
 1.26A 4uciA-1xofA:
undetectable		 4uciA-1xofA:
4.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 PHE A  48
ARG A  47
PHE A 305
TYR A 300
 None
 1.48A 4uciA-1y4uA:
undetectable		 4uciA-1y4uA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxq INTERCELLULAR
ADHESION MOLECULE-2

(Homo sapiens) 		PF03921
(ICAM_N) 		4 GLU A   4
PHE A   3
PHE A  69
HIS A   6
 None
 1.39A 4uciA-1zxqA:
undetectable		 4uciA-1zxqA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5r CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 7
TOB1 PROTEIN

(Homo sapiens) 		PF04857
(CAF1)
PF07742
(BTG) 		4 GLU A 247
PHE A 246
PHE A 245
TYR B  74
 None
 1.33A 4uciA-2d5rA:
undetectable		 4uciA-2d5rA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d87 SMOOTHELIN SPLICE
ISOFORM L2

(Homo sapiens) 		PF00307
(CH) 		4 GLU A  68
PHE A  67
PHE A  41
TYR A 103
 None
 1.45A 4uciA-2d87A:
undetectable		 4uciA-2d87A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 GLU A 539
PHE A 538
PHE A 548
TYR A 559
 None
 1.26A 4uciA-2dfsA:
undetectable		 4uciA-2dfsA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 GLU A   3
PHE A  39
PHE A 106
HIS A  38
 None
 1.11A 4uciA-2dpgA:
undetectable		 4uciA-2dpgA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewo PUTATIVE AGMATINE
DEIMINASE

(Streptococcus
mutans) 		PF04371
(PAD_porph) 		4 GLU A  20
PHE A  21
PHE A 229
HIS A 166
 None
 1.47A 4uciA-2ewoA:
undetectable		 4uciA-2ewoA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		4 GLU A 261
PHE A 260
ARG A 284
PHE A 249
 None
 1.49A 4uciA-2gtiA:
undetectable		 4uciA-2gtiA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hih LIPASE 46 KDA FORM

(Staphylococcus
hyicus) 		no annotation 4 GLU A 372
PHE A 376
PHE A 358
HIS A 368
 None
 1.05A 4uciA-2hihA:
undetectable		 4uciA-2hihA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLU A 352
PHE A 486
PHE A 425
HIS A 490
 None
 1.23A 4uciA-2hz0A:
undetectable		 4uciA-2hz0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ou2 HISTONE
ACETYLTRANSFERASE
HTATIP

(Homo sapiens) 		PF01853
(MOZ_SAS) 		4 GLU A 212
PHE A 297
TYR A 292
HIS A 298
 None
 1.44A 4uciA-2ou2A:
undetectable		 4uciA-2ou2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE 2 DNA
TOPOISOMERASE 6
SUBUNIT B

(Methanosarcina
mazei) 		PF02518
(HATPase_c)
PF09239
(Topo-VIb_trans) 		4 GLU B 239
PHE B 304
PHE B 266
HIS B 237
 None
 1.39A 4uciA-2q2eB:
undetectable		 4uciA-2q2eB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4i GLUTAMATE RACEMASE

(Helicobacter
pylori) 		PF01177
(Asp_Glu_race) 		4 GLU A 235
PHE A  58
TYR A  31
HIS A 237
 None
 1.39A 4uciA-2w4iA:
undetectable		 4uciA-2w4iA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ytv COLD SHOCK
DOMAIN-CONTAINING
PROTEIN E1

(Homo sapiens) 		PF00313
(CSD) 		4 GLU A  51
ARG A   9
PHE A  54
TYR A  25
 None
 1.41A 4uciA-2ytvA:
undetectable		 4uciA-2ytvA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afl OLIGO ALGINATE LYASE

(Agrobacterium
fabrum) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		4 GLU A  30
PHE A 114
TYR A  90
HIS A  89
 None
 1.17A 4uciA-3aflA:
undetectable		 4uciA-3aflA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 GLU A 106
PHE A 109
TYR A 156
HIS A 155
 None
None
NAD  A 901 (-4.8A)
None
 1.44A 4uciA-3ak4A:
undetectable		 4uciA-3ak4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
kodakarensis) 		PF05916
(Sld5) 		4 GLU B  76
PHE B  80
TYR B  83
HIS B   0
 None
 1.41A 4uciA-3anwB:
undetectable		 4uciA-3anwB:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bm3 PSPGI RESTRICTION
ENDONUCLEASE

(Pyrococcus sp.
GI-H) 		PF09019
(EcoRII-C) 		4 GLU A 105
PHE A 108
TYR A 119
HIS A 121
 None
 1.27A 4uciA-3bm3A:
undetectable		 4uciA-3bm3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv6 METAL-DEPENDENT
HYDROLASE

(Vibrio cholerae) 		PF13483
(Lactamase_B_3) 		4 GLU A 297
ARG A 330
PHE A 314
HIS A 332
 None
 1.21A 4uciA-3bv6A:
undetectable		 4uciA-3bv6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c26 PUTATIVE
ACETYLTRANSFERASE
TA0821

(Thermoplasma
acidophilum) 		PF00583
(Acetyltransf_1) 		4 PHE A 217
ARG A 243
PHE A 175
TYR A 180
 None
 1.09A 4uciA-3c26A:
undetectable		 4uciA-3c26A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csw PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF01063
(Aminotran_4) 		4 GLU A  32
PHE A  69
PHE A  66
TYR A  45
 None
 1.47A 4uciA-3cswA:
undetectable		 4uciA-3cswA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		4 PHE A 349
ARG A 271
PHE A 274
TYR A 359
 None
 1.16A 4uciA-3e38A:
undetectable		 4uciA-3e38A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etc AMP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLU A  15
PHE A  14
PHE A  20
TYR A  17
 None
 1.47A 4uciA-3etcA:
undetectable		 4uciA-3etcA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhn PROTEIN TRANSPORT
PROTEIN TIP20

(Saccharomyces
cerevisiae) 		PF04437
(RINT1_TIP1) 		4 PHE A 252
ARG A 251
PHE A 248
TYR A 275
 None
 1.50A 4uciA-3fhnA:
undetectable		 4uciA-3fhnA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gas HEME OXYGENASE

(Helicobacter
pylori) 		PF01243
(Putative_PNPOx)
PF10615
(DUF2470) 		4 GLU A 132
PHE A 175
ARG A 178
TYR A 129
 None
 1.49A 4uciA-3gasA:
undetectable		 4uciA-3gasA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h9j MCCB PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		4 GLU A  62
PHE A  65
ARG A  70
PHE A  69
 None
 1.02A 4uciA-3h9jA:
undetectable		 4uciA-3h9jA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isa PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Bordetella
parapertussis) 		PF00378
(ECH_1) 		4 GLU A  78
PHE A 234
ARG A 239
TYR A  73
 None
 1.43A 4uciA-3isaA:
undetectable		 4uciA-3isaA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jwe MGLL PROTEIN

(Homo sapiens) 		PF12146
(Hydrolase_4) 		4 GLU A 144
ARG A 229
PHE A 103
HIS A 104
 None
 1.47A 4uciA-3jweA:
undetectable		 4uciA-3jweA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 PHE A 361
ARG A 360
PHE A 364
TYR A 347
 None
 1.48A 4uciA-3kv4A:
undetectable		 4uciA-3kv4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4i HEAT SHOCK 70
(HSP70) PROTEIN

(Cryptosporidium
parvum) 		PF00012
(HSP70) 		4 PHE A 319
ARG A 252
PHE A 249
TYR A 326
 None
 1.07A 4uciA-3l4iA:
undetectable		 4uciA-3l4iA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		4 GLU A 583
PHE A 584
PHE A 586
TYR A 566
 None
 1.48A 4uciA-3l5hA:
undetectable		 4uciA-3l5hA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0w ABC BRANCHED CHAIN
AMINO ACID FAMILY
TRANSPORTER,
PERIPLASMIC LIGAND
BINDING PROTEIN

(Paraburkholderia
xenovorans) 		PF13458
(Peripla_BP_6) 		4 PHE A 291
ARG A 290
PHE A 287
TYR A 307
 None
 1.45A 4uciA-3n0wA:
undetectable		 4uciA-3n0wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 GLU A 122
PHE A 121
PHE A 120
TYR A  78
 None
 1.40A 4uciA-3ogrA:
undetectable		 4uciA-3ogrA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quw PROTEIN MMF1

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 GLU A  70
PHE A 106
TYR A 110
HIS A 113
 None
 1.40A 4uciA-3quwA:
undetectable		 4uciA-3quwA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		4 GLU A 491
PHE A 493
TYR A 669
HIS A 490
 None
 1.45A 4uciA-3snhA:
undetectable		 4uciA-3snhA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		4 GLU A 129
PHE A 130
PHE A  80
HIS A 127
 None
 1.48A 4uciA-3v10A:
undetectable		 4uciA-3v10A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 GLU A 149
PHE A 173
PHE A 172
HIS A 177
 None
 1.39A 4uciA-3vtrA:
undetectable		 4uciA-3vtrA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbq PHIKZ039

(Pseudomonas
virus phiKZ) 		no annotation 4 PHE A  11
PHE A  23
TYR A  26
HIS A  24
 None
 1.22A 4uciA-3zbqA:
undetectable		 4uciA-3zbqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 GLU A1058
PHE A1044
ARG A1049
PHE A1048
 None
 1.29A 4uciA-3zgxA:
undetectable		 4uciA-3zgxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 PHE A 365
ARG A 360
PHE A 359
HIS A 358
 None
 1.23A 4uciA-4acqA:
undetectable		 4uciA-4acqA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 GLU A  68
PHE A  67
PHE A  65
HIS A  66
 None
 1.49A 4uciA-4e8dA:
undetectable		 4uciA-4e8dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ejs ELONGATOR COMPLEX
PROTEIN 5

(Saccharomyces
cerevisiae) 		PF10483
(Elong_Iki1) 		4 GLU B  61
PHE B  60
TYR B 135
HIS B 136
 None
 0.98A 4uciA-4ejsB:
undetectable		 4uciA-4ejsB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4p ACYLNEURAMINATE
LYASE

(Mycoplasma
synoviae) 		PF00701
(DHDPS) 		4 GLU A 177
PHE A 176
PHE A 188
TYR A 183
 None
 1.24A 4uciA-4n4pA:
undetectable		 4uciA-4n4pA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oz5 BACILLUS SUBTILIS
HMOB

(Bacillus
subtilis) 		PF03992
(ABM) 		4 PHE A 153
ARG A  79
PHE A  82
TYR A 113
 None
 1.08A 4uciA-4oz5A:
undetectable		 4uciA-4oz5A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 GLU A 273
PHE A 268
PHE A 267
HIS A 269
 None
 1.33A 4uciA-4rhhA:
undetectable		 4uciA-4rhhA:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 5 GLU A1781
PHE A1782
PHE A1788
TYR A1818
HIS A1819
 None
 0.51A 4uciA-4uclA:
58.4		 4uciA-4uclA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvk ZYRO0D15994P

(Zygosaccharomyces
rouxii) 		PF08514
(STAG) 		4 PHE A 335
ARG A 338
PHE A 339
HIS A 337
 None
 1.12A 4uciA-4uvkA:
undetectable		 4uciA-4uvkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 GLU B 371
PHE B 505
PHE B 444
HIS B 509
 None
 1.25A 4uciA-4xeyB:
undetectable		 4uciA-4xeyB:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgk UDP-GALACTOPYRANOSE
MUTASE

(Corynebacterium
diphtheriae) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 GLU A  54
PHE A 292
TYR A  83
HIS A 296
 None
 1.46A 4uciA-4xgkA:
undetectable		 4uciA-4xgkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		4 GLU A 129
PHE A 133
TYR A 134
HIS A 147
 MN  A 303 (-2.6A)
MDM  A 304 ( 3.5A)
None
MN  A 303 (-3.3A)
 1.29A 4uciA-5eyyA:
undetectable		 4uciA-5eyyA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghf AMINOTRANSFERASE
CLASS-III

(Ochrobactrum
anthropi) 		PF00202
(Aminotran_3) 		4 GLU A 373
PHE A 186
PHE A 199
HIS A 185
 None
 1.31A 4uciA-5ghfA:
undetectable		 4uciA-5ghfA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 GLU A 537
PHE A 536
PHE A 546
TYR A 557
 None
 1.39A 4uciA-5hmpA:
undetectable		 4uciA-5hmpA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL

(Homo sapiens) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		4 GLU A 442
PHE A 441
ARG A 326
TYR A 444
 None
 1.45A 4uciA-5hphA:
undetectable		 4uciA-5hphA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5juf TRANSCRIPTIONAL
REGULATOR

(Streptococcus
thermophilus) 		PF01381
(HTH_3) 		4 GLU A 142
PHE A 149
TYR A 169
HIS A 172
 None
 1.03A 4uciA-5jufA:
undetectable		 4uciA-5jufA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 GLU A  37
ARG A 263
TYR A 268
HIS A 269
 None
 1.37A 4uciA-5k9hA:
undetectable		 4uciA-5k9hA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5liv CYTOCHROME P450
CYP260A1,CYTOCHROME
P450 CYP260A1

(Sorangium
cellulosum) 		PF00067
(p450) 		4 PHE A  60
ARG A  72
PHE A  59
HIS A 434
 None
 1.39A 4uciA-5livA:
undetectable		 4uciA-5livA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5np9 TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN TSAE

(Bacillus
subtilis) 		no annotation 4 GLU A 106
PHE A  44
PHE A  48
HIS A  78
 MG  A 202 ( 2.5A)
None
None
None
 1.25A 4uciA-5np9A:
undetectable		 4uciA-5np9A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		no annotation 4 GLU C 463
PHE C 545
TYR C 435
HIS C 546
 ACT  C 611 (-4.4A)
None
None
None
 1.06A 4uciA-5oyjC:
undetectable		 4uciA-5oyjC:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacterium
smegmatis) 		PF01261
(AP_endonuc_2) 		4 ARG A 238
PHE A 240
TYR A 247
HIS A 211
 None
 1.35A 4uciA-5tnvA:
undetectable		 4uciA-5tnvA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7x NOD FACTOR BINDING
LECTIN-NUCLEOTIDE
PHOSPHOHYDROLASE

(Vigna
unguiculata) 		PF01150
(GDA1_CD39) 		4 GLU F 185
ARG F 268
PHE F 280
TYR F 209
 None
 1.18A 4uciA-5u7xF:
undetectable		 4uciA-5u7xF:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve9 MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 PHE A7049
ARG A7051
PHE A7050
TYR A7099
 None
 1.23A 4uciA-5ve9A:
undetectable		 4uciA-5ve9A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Saccharum
hybrid cultivar) 		no annotation 4 GLU A 249
PHE A 350
ARG A 273
PHE A 349
 None
 1.43A 4uciA-5wegA:
undetectable		 4uciA-5wegA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 4 GLU P 490
PHE P 489
PHE P 510
TYR P 521
 None
 1.35A 4uciA-6c1dP:
undetectable		 4uciA-6c1dP:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 GLU E 275
ARG E 282
PHE E 178
TYR E 383
 None
 1.31A 4uciA-6d04E:
undetectable		 4uciA-6d04E:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d14 TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		no annotation 4 GLU A 457
PHE A 456
ARG A 341
TYR A 459
 None
 1.30A 4uciA-6d14A:
undetectable		 4uciA-6d14A:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fri ALKANAL
MONOOXYGENASE BETA
CHAIN

(Photobacterium
leiognathi) 		no annotation 4 GLU A 255
PHE A 114
PHE A  48
HIS A  46
 None
 1.48A 4uciA-6friA:
undetectable		 4uciA-6friA:
10.86