SIMILAR PATTERNS OF AMINO ACIDS FOR 4UBS_A_DIFA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens) 		PF00191
(Annexin) 		5 LEU A 273
LEU A  88
THR A 315
LEU A 316
ILE A 319
 None
 1.26A 4ubsA-1axnA:
0.0		 4ubsA-1axnA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 VAL A 175
LEU A  59
LEU A 252
THR A 110
ILE A 114
 None
 1.20A 4ubsA-1c3rA:
0.0		 4ubsA-1c3rA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep2 DIHYDROOROTATE
DEHYDROGENASE B
(PYRK SUBUNIT)

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		5 ARG B 215
VAL B 107
LEU B 216
LEU B 132
ILE B 115
 None
 1.29A 4ubsA-1ep2B:
0.0		 4ubsA-1ep2B:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 VAL A 595
LEU A 634
SER A 575
LEU A 545
ILE A 544
 None
 1.33A 4ubsA-1hwwA:
0.0		 4ubsA-1hwwA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A  52
LEU A 215
THR A 180
LEU A 181
ILE A 193
 None
 1.22A 4ubsA-1i1qA:
0.0		 4ubsA-1i1qA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ij5 PLASMODIAL SPECIFIC
LAV1-2 PROTEIN

(Physarum
polycephalum) 		PF13202
(EF-hand_5) 		5 VAL A 348
LEU A 222
LEU A 290
LEU A 285
ILE A 289
 None
 1.25A 4ubsA-1ij5A:
1.1		 4ubsA-1ij5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		5 LEU A  79
SER A 204
THR A 134
LEU A 133
ILE A 135
 None
 1.23A 4ubsA-1j93A:
0.0		 4ubsA-1j93A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k25 LOW-AFFINITY
PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		5 VAL A 663
LEU A 746
LEU A 714
LEU A 718
ILE A 716
 None
 1.33A 4ubsA-1k25A:
0.0		 4ubsA-1k25A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		5 LEU A2800
LEU A2650
SER A2792
LEU A2802
ILE A2622
 None
 1.08A 4ubsA-1lm5A:
undetectable		 4ubsA-1lm5A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		5 LEU A 106
LEU A 184
ARG A 138
LEU A 125
ILE A 158
 None
 1.09A 4ubsA-1to3A:
undetectable		 4ubsA-1to3A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE

(Bacillus
coagulans) 		PF00180
(Iso_dh) 		5 LEU A 294
LEU A  25
SER A 299
LEU A 298
ILE A 317
 None
 1.09A 4ubsA-1v5bA:
undetectable		 4ubsA-1v5bA:
25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve4 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF01634
(HisG) 		5 LEU A  23
ARG A 178
SER A 204
LEU A 200
ILE A 197
 None
 1.32A 4ubsA-1ve4A:
undetectable		 4ubsA-1ve4A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkm CONSERVED
HYPOTHETICAL PROTEIN
TM1464

(Thermotoga
maritima) 		PF04227
(Indigoidine_A) 		5 VAL A   1
LEU A  54
LEU A 103
THR A  95
ILE A  51
 None
 1.27A 4ubsA-1vkmA:
undetectable		 4ubsA-1vkmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		5 ARG C 272
LEU C 194
ARG C 202
THR C 229
LEU C 232
 HEM  C 403 (-2.9A)
None
HEM  C 403 (-4.1A)
HEM  C 403 ( 4.8A)
None
 1.36A 4ubsA-1vrnC:
undetectable		 4ubsA-1vrnC:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woy METHIONYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF09334
(tRNA-synt_1g) 		5 ARG A 392
LEU A 391
THR A 385
LEU A 387
ILE A 447
 None
 1.36A 4ubsA-1woyA:
1.4		 4ubsA-1woyA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		5 ARG A  91
LEU A 116
SER A  38
THR A  37
LEU A  41
 None
 1.31A 4ubsA-1wz9A:
undetectable		 4ubsA-1wz9A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xcj GUANIDINOACETATE
N-METHYLTRANSFERASE

(Rattus
norvegicus) 		no annotation 5 LEU A  52
LEU A 159
ARG A  59
LEU A 132
ILE A 131
 None
 1.22A 4ubsA-1xcjA:
undetectable		 4ubsA-1xcjA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		5 VAL A   8
LEU A  96
SER A 118
LEU A 115
ILE A 127
 None
 1.36A 4ubsA-1xwwA:
undetectable		 4ubsA-1xwwA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		5 LEU A 180
ARG A 174
SER A 168
LEU A 164
ILE A 182
 None
 1.25A 4ubsA-2a5vA:
undetectable		 4ubsA-2a5vA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 299
LEU A 276
ARG A 323
LEU A 317
ILE A 314
 None
 1.36A 4ubsA-2akjA:
undetectable		 4ubsA-2akjA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6c HYPOTHETICAL PROTEIN
EF3068

(Enterococcus
faecalis) 		PF08713
(DNA_alkylation) 		5 LEU A 119
LEU A  85
THR A 124
LEU A 122
ILE A 125
 None
 1.33A 4ubsA-2b6cA:
undetectable		 4ubsA-2b6cA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP7 CORE
PROTEIN)

(Bluetongue
virus) 		no annotation 5 VAL P 270
LEU P 308
ARG P 286
THR P 289
ILE P  75
 None
 1.09A 4ubsA-2btvP:
undetectable		 4ubsA-2btvP:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 LEU A 300
LEU A 487
SER A 437
LEU A 441
ILE A 443
 None
 1.27A 4ubsA-2h2qA:
undetectable		 4ubsA-2h2qA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		5 LEU A1430
ARG A1454
THR A1591
LEU A1564
ILE A1563
 None
 1.36A 4ubsA-2ix8A:
undetectable		 4ubsA-2ix8A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus) 		PF00696
(AA_kinase) 		5 LEU A 214
SER A 132
THR A 134
LEU A 135
ILE A 200
 None
 1.00A 4ubsA-2j4lA:
undetectable		 4ubsA-2j4lA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyl MICROTUBULE-ASSOCIAT
ED
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  94
LEU A  54
THR A  91
LEU A  59
ILE A  60
 None
 1.32A 4ubsA-2kylA:
undetectable		 4ubsA-2kylA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n6j ZINC METALLOPROTEASE
ZMP1

(Clostridioides
difficile) 		PF07737
(ATLF) 		5 VAL A 152
LEU A  61
THR A  37
LEU A  38
ILE A  41
 None
 1.36A 4ubsA-2n6jA:
undetectable		 4ubsA-2n6jA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR
FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3)
PF00104
(Hormone_recep) 		5 ARG D  33
LEU A 327
LEU A 540
THR A 347
LEU A 349
 None
None
None
None
EST  A 596 ( 4.1A)
 1.36A 4ubsA-2ocfD:
undetectable		 4ubsA-2ocfD:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2paj PUTATIVE
CYTOSINE/GUANINE
DEAMINASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 LEU A  52
SER A  11
THR A  12
LEU A  13
ILE A  14
 None
 1.27A 4ubsA-2pajA:
undetectable		 4ubsA-2pajA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 693
SER A 730
THR A 731
LEU A 732
ILE A 733
 None
 1.26A 4ubsA-2pffA:
undetectable		 4ubsA-2pffA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pge MENC

(Desulfotalea
psychrophila) 		PF13378
(MR_MLE_C) 		5 LEU A 290
LEU A  54
SER A 293
LEU A 295
ILE A 269
 None
 1.27A 4ubsA-2pgeA:
undetectable		 4ubsA-2pgeA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		5 LEU A  56
SER A  86
THR A  89
LEU A  90
ILE A 113
 None
 1.02A 4ubsA-2qksA:
undetectable		 4ubsA-2qksA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qza SECRETED EFFECTOR
PROTEIN

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 346
LEU A 331
THR A 359
LEU A 357
ILE A 360
 None
 1.37A 4ubsA-2qzaA:
undetectable		 4ubsA-2qzaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tpt THYMIDINE
PHOSPHORYLASE

(Escherichia
coli) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 220
SER A 186
THR A 184
LEU A 182
ILE A 180
 None
 1.34A 4ubsA-2tptA:
undetectable		 4ubsA-2tptA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uzp PROTEIN KINASE C
GAMMA TYPE

(Homo sapiens) 		PF00168
(C2) 		5 VAL A 196
LEU A 200
LEU A 163
SER A 260
ILE A 165
 None
 1.27A 4ubsA-2uzpA:
undetectable		 4ubsA-2uzpA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vla RESTRICTION
ENDONUCLEASE R.BPUJI

(Bacillus
pumilus) 		PF11564
(BpuJI_N) 		5 VAL A 164
LEU A 146
LEU A 214
LEU A 232
ILE A 223
 None
 1.21A 4ubsA-2vlaA:
undetectable		 4ubsA-2vlaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 VAL A 192
LEU A 239
LEU A 153
LEU A 250
ILE A 251
 None
 1.31A 4ubsA-2ykyA:
undetectable		 4ubsA-2ykyA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv2 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Aeropyrum
pernix) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		5 LEU A 210
LEU A   9
SER A 179
THR A 180
ILE A 182
 None
 1.29A 4ubsA-2yv2A:
undetectable		 4ubsA-2yv2A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bij UNCHARACTERIZED
PROTEIN GSU0716

(Geobacter
sulfurreducens) 		PF00656
(Peptidase_C14) 		5 LEU A  50
LEU A 115
SER A  80
LEU A   7
ILE A  64
 None
 1.00A 4ubsA-3bijA:
undetectable		 4ubsA-3bijA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME

(Corynebacterium
glutamicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 315
LEU A 274
SER A 320
THR A 321
ILE A 324
 LEU  A 315 ( 0.6A)
LEU  A 274 ( 0.6A)
SER  A 320 ( 0.0A)
THR  A 321 ( 0.8A)
ILE  A 324 ( 0.7A)
 1.30A 4ubsA-3i4kA:
undetectable		 4ubsA-3i4kA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7z PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Sulfolobus
solfataricus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 VAL B 114
LEU B 194
SER A 241
THR B 198
ILE B 158
 None
 1.29A 4ubsA-3l7zB:
undetectable		 4ubsA-3l7zB:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3las PUTATIVE CARBONIC
ANHYDRASE

(Streptococcus
mutans) 		PF00484
(Pro_CA) 		5 VAL A 131
LEU A  74
LEU A  89
LEU A  59
ILE A  35
 None
 1.33A 4ubsA-3lasA:
undetectable		 4ubsA-3lasA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN

(Rhodopseudomonas
palustris) 		PF02743
(dCache_1) 		5 VAL A 168
LEU A 106
SER A 125
LEU A 102
ILE A  81
 None
 1.26A 4ubsA-3lifA:
undetectable		 4ubsA-3lifA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npg UNCHARACTERIZED
DUF364 FAMILY
PROTEIN

(Pyrococcus
horikoshii) 		PF04016
(DUF364)
PF13938
(DUF4213) 		5 LEU A 201
LEU A  98
SER A 216
LEU A 214
ILE A 246
 None
 1.23A 4ubsA-3npgA:
undetectable		 4ubsA-3npgA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		5 ARG A 189
VAL A 193
LEU A 138
ARG A 157
SER A 148
 None
 1.36A 4ubsA-3ntxA:
undetectable		 4ubsA-3ntxA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		5 LEU A 440
LEU A 507
ARG A 503
SER A 486
ILE A 510
 None
 1.29A 4ubsA-3o4zA:
2.2		 4ubsA-3o4zA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6n APL1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 VAL A 168
LEU A 209
SER A 188
THR A 189
LEU A 212
 None
 1.30A 4ubsA-3o6nA:
undetectable		 4ubsA-3o6nA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 VAL B 168
LEU B 209
SER B 188
THR B 189
LEU B 212
 None
 1.29A 4ubsA-3ojaB:
undetectable		 4ubsA-3ojaB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3on4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Legionella
pneumophila) 		PF00440
(TetR_N) 		5 LEU A 164
ARG A 168
SER A  99
LEU A  95
ILE A  92
 None
 1.26A 4ubsA-3on4A:
undetectable		 4ubsA-3on4A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vly NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 299
LEU A 276
ARG A 323
LEU A 317
ILE A 314
 None
 1.34A 4ubsA-3vlyA:
undetectable		 4ubsA-3vlyA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evq PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 VAL A 328
LEU A  94
LEU A 317
LEU A 103
ILE A 104
 None
 1.35A 4ubsA-4evqA:
undetectable		 4ubsA-4evqA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 174
LEU A 115
LEU A 319
LEU A   9
ILE A   6
 None
 1.34A 4ubsA-4ewtA:
undetectable		 4ubsA-4ewtA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		5 VAL W 765
LEU W 713
THR W 136
LEU W 135
ILE W 134
 None
 1.31A 4ubsA-4f5xW:
undetectable		 4ubsA-4f5xW:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		5 VAL A 314
LEU A 169
LEU A  92
LEU A 145
ILE A 146
 None
 1.22A 4ubsA-4gx8A:
undetectable		 4ubsA-4gx8A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hd1 SQUALENE SYNTHASE
HPNC

(Alicyclobacillus
acidocaldarius) 		PF00494
(SQS_PSY) 		5 LEU A 125
LEU A 194
ARG A 184
THR A 118
ILE A 180
 None
 1.12A 4ubsA-4hd1A:
undetectable		 4ubsA-4hd1A:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DM BETA
CHAIN

(Homo sapiens) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		5 LEU B  51
LEU B  62
THR B  34
LEU B  33
ILE B  26
 None
 1.36A 4ubsA-4i0pB:
undetectable		 4ubsA-4i0pB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00180
(Iso_dh) 		5 LEU A 294
LEU A  23
SER A 299
LEU A 298
ILE A 317
 None
 1.26A 4ubsA-4iwhA:
undetectable		 4ubsA-4iwhA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je3 CENTRAL KINETOCHORE
SUBUNIT IML3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 210
LEU A 228
SER A 224
THR A 223
ILE A 221
 None
 1.27A 4ubsA-4je3A:
undetectable		 4ubsA-4je3A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		no annotation 5 LEU C 126
LEU C 191
SER C 207
THR C 209
ILE C 129
 None
 1.30A 4ubsA-4kd5C:
undetectable		 4ubsA-4kd5C:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5a PROTEIN EFR3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 344
LEU A 301
ARG A 304
SER A 307
LEU A 306
 None
 1.35A 4ubsA-4n5aA:
2.6		 4ubsA-4n5aA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nvt TRIOSEPHOSPHATE
ISOMERASE

(Brucella
melitensis) 		PF00121
(TIM) 		5 ARG A 103
VAL A 131
LEU A 112
LEU A 155
THR A 117
 None
 1.30A 4ubsA-4nvtA:
undetectable		 4ubsA-4nvtA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pay SIDC, INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 VAL A 300
LEU A 314
LEU A 252
LEU A 279
ILE A 256
 None
 1.30A 4ubsA-4payA:
1.9		 4ubsA-4payA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pke PROTEIN C10C5.1,
ISOFORM I

(Caenorhabditis
elegans) 		PF12166
(Piezo_RRas_bdg) 		5 LEU A 193
LEU A 256
SER A 196
THR A 200
ILE A 201
 None
 1.07A 4ubsA-4pkeA:
undetectable		 4ubsA-4pkeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6l BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A 354
LEU A 340
SER A 332
LEU A 333
ILE A 337
 None
 1.11A 4ubsA-4r6lA:
undetectable		 4ubsA-4r6lA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trg SIDC

(Legionella
pneumophila) 		no annotation 5 VAL A 300
LEU A 314
LEU A 252
LEU A 279
ILE A 256
 None
 1.31A 4ubsA-4trgA:
2.0		 4ubsA-4trgA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 LEU A  93
ARG A 464
THR A  97
LEU A 300
ILE A 301
 None
 1.35A 4ubsA-4wd9A:
undetectable		 4ubsA-4wd9A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsi MAGUK P55 SUBFAMILY
MEMBER 5

(Homo sapiens) 		PF00595
(PDZ)
PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		5 VAL A 563
LEU A 585
SER A 576
LEU A 484
ILE A 594
 None
 1.25A 4ubsA-4wsiA:
undetectable		 4ubsA-4wsiA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xru PNKP1

(Capnocytophaga
gingivalis) 		PF13671
(AAA_33) 		5 ARG A 236
LEU A 243
SER A 229
LEU A 227
ILE A 226
 None
 1.31A 4ubsA-4xruA:
undetectable		 4ubsA-4xruA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yet SUPEROXIDE DISMUTASE

(Babesia bovis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 VAL A 159
LEU A 155
LEU A 114
LEU A 126
ILE A 136
 None
 1.36A 4ubsA-4yetA:
1.7		 4ubsA-4yetA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		5 LEU B  75
LEU B 233
THR B  90
LEU B 137
ILE B 138
 None
 1.35A 4ubsA-4yjfB:
undetectable		 4ubsA-4yjfB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9a LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		5 VAL A   8
LEU A  96
SER A 118
LEU A 115
ILE A 127
 None
 1.37A 4ubsA-4z9aA:
undetectable		 4ubsA-4z9aA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		5 ARG A 315
SER A 330
THR A 329
LEU A  12
ILE A 362
 None
 1.29A 4ubsA-4zasA:
undetectable		 4ubsA-4zasA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zn0 THIOREDOXIN
REDUCTASE

(Methanosarcina
mazei) 		PF07992
(Pyr_redox_2) 		5 VAL A 183
LEU A 160
ARG A 187
THR A 191
ILE A 194
 None
 1.32A 4ubsA-4zn0A:
undetectable		 4ubsA-4zn0A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		5 VAL A 340
LEU A 270
LEU A 394
SER B  34
LEU B  37
 None
 1.37A 4ubsA-5c6gA:
2.8		 4ubsA-5c6gA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1p ATP-DEPENDENT RNA
LIGASE

(Methanothermobacter
thermautotrophicus) 		PF09414
(RNA_ligase) 		5 VAL A 347
LEU A 351
ARG A 363
THR A 325
ILE A 327
 None
 1.25A 4ubsA-5d1pA:
undetectable		 4ubsA-5d1pA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL B 723
LEU B 766
SER B 738
LEU B 736
ILE B 774
 None
 1.32A 4ubsA-5eduB:
undetectable		 4ubsA-5eduB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyj PUTATIVE PEPTIDASE
C60B, SORTASE B

(Clostridioides
difficile) 		PF04203
(Sortase) 		5 VAL A 161
LEU A 168
ARG A 217
LEU A 206
ILE A 112
 None
 1.34A 4ubsA-5gyjA:
undetectable		 4ubsA-5gyjA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3h ABHYDROLASE
DOMAIN-CONTAINING
PROTEIN

(Exiguobacterium
antarcticum) 		PF00561
(Abhydrolase_1)
PF08386
(Abhydrolase_4) 		5 LEU A  27
LEU A 262
THR A  91
LEU A  92
ILE A 118
 None
 1.37A 4ubsA-5h3hA:
undetectable		 4ubsA-5h3hA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 5 VAL A 270
LEU A 316
SER A 296
THR A 299
LEU A 300
 None
 1.05A 4ubsA-5hssA:
undetectable		 4ubsA-5hssA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 VAL A 601
LEU A 670
LEU A 606
SER A 679
LEU A 680
 None
 1.31A 4ubsA-5irmA:
undetectable		 4ubsA-5irmA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jph ACETYLTRANSFERASE
SACOL1063

(Staphylococcus
aureus) 		PF13673
(Acetyltransf_10) 		5 LEU A  93
ARG A  57
THR A  55
LEU A  44
ILE A  45
 None
COA  A 201 (-3.8A)
CL  A 203 (-3.8A)
None
None
 1.23A 4ubsA-5jphA:
undetectable		 4ubsA-5jphA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA

(Salmonella
enterica) 		PF13599
(Pentapeptide_4)
PF13981
(SopA) 		5 LEU A 346
LEU A 331
THR A 359
LEU A 357
ILE A 360
 None
 1.21A 4ubsA-5jw7A:
2.2		 4ubsA-5jw7A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		5 LEU A 304
LEU A 615
THR A 309
LEU A 308
ILE A 310
 None
 1.34A 4ubsA-5k3jA:
0.3		 4ubsA-5k3jA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		5 LEU A 371
SER A 345
THR A 348
LEU A 349
ILE A 351
 None
7O9  A 602 (-2.7A)
None
7O9  A 602 (-3.5A)
None
 1.19A 4ubsA-5mjuA:
undetectable		 4ubsA-5mjuA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mus L PROTEIN

(California
reptarenavirus) 		no annotation 5 LEU A2025
SER A2001
THR A2002
LEU A2003
ILE A1995
 None
 1.21A 4ubsA-5musA:
undetectable		 4ubsA-5musA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 5 ARG B  80
VAL B 844
LEU B  83
LEU B 190
ILE B 188
 None
 1.33A 4ubsA-5my0B:
undetectable		 4ubsA-5my0B:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tov ADENOSYLHOMOCYSTEINA
SE

(Thermotoga
maritima) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  53
LEU A  42
THR A  46
LEU A  49
ILE A  40
 None
 1.35A 4ubsA-5tovA:
undetectable		 4ubsA-5tovA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 244
LEU A 186
THR A 256
LEU A 257
ILE A 258
 None
 1.23A 4ubsA-5v36A:
undetectable		 4ubsA-5v36A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmj FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Desulfovibrio
gigas) 		no annotation 5 VAL A 246
LEU A 184
THR A 212
LEU A 213
ILE A  11
 None
None
None
None
FAD  A 701 (-4.7A)
 0.99A 4ubsA-5xmjA:
undetectable		 4ubsA-5xmjA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED

(Oryza sativa) 		no annotation 5 ARG A 363
VAL A 341
LEU A 364
THR A 367
LEU A 366
 SIN  A 401 (-2.8A)
None
None
SIN  A 401 ( 4.4A)
None
 1.32A 4ubsA-5xoiA:
undetectable		 4ubsA-5xoiA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yid PLASMEPSIN II

(Plasmodium
falciparum) 		no annotation 5 VAL A  44
LEU A  35
SER A  39
LEU A 128
ILE A 141
 None
None
K95  A 401 ( 4.8A)
None
None
 1.21A 4ubsA-5yidA:
undetectable		 4ubsA-5yidA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zct -

(-) 		no annotation 5 VAL A 244
LEU A  77
LEU A  18
LEU A   6
ILE A   5
 None
 1.31A 4ubsA-5zctA:
undetectable		 4ubsA-5zctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zkp PLATELET-ACTIVATING
FACTOR
RECEPTOR,FLAVODOXIN,
PLATELET-ACTIVATING
FACTOR RECEPTOR

(Desulfovibrio
vulgaris;
Homo sapiens) 		no annotation 5 LEU A  89
LEU A  65
THR A  69
LEU A  72
ILE A  68
 None
 1.27A 4ubsA-5zkpA:
1.3		 4ubsA-5zkpA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 LEU A  73
SER A 368
THR A 371
LEU A 372
ILE A 375
 None
 0.97A 4ubsA-6aphA:
undetectable		 4ubsA-6aphA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 5 ARG A 221
VAL A 302
LEU A 214
THR A 307
ILE A 309
 None
 1.31A 4ubsA-6enoA:
undetectable		 4ubsA-6enoA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezn DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT WBP1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU G  57
LEU G  44
THR G  26
LEU G  27
ILE G  80
 None
 1.35A 4ubsA-6eznG:
undetectable		 4ubsA-6eznG:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5z 24-STEROL
C-METHYLTRANSFERASE

(Haloferax
volcanii) 		no annotation 5 VAL A  43
LEU A 177
LEU A  97
THR A 122
LEU A 123
 None
 1.32A 4ubsA-6f5zA:
undetectable		 4ubsA-6f5zA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fl0 -

(-) 		no annotation 5 ARG A 114
LEU A 188
SER A 144
THR A 148
ILE A 108
 None
 1.31A 4ubsA-6fl0A:
undetectable		 4ubsA-6fl0A:
undetectable