SIMILAR PATTERNS OF AMINO ACIDS FOR 4U9U_A_ACTA1502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		4 GLY A  17
ALA A  16
GLY A  65
PRO A  66
 None
 0.85A 4u9uA-1h3gA:
undetectable		 4u9uA-1h3gA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iv8 MALTOOLIGOSYL
TREHALOSE SYNTHASE

(Sulfolobus
acidocaldarius) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ARG A 430
GLY A 579
ALA A 578
GLY A 432
 None
 0.94A 4u9uA-1iv8A:
2.1		 4u9uA-1iv8A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		4 GLY A 263
ALA A 432
GLY A 266
PRO A 267
 None
 0.86A 4u9uA-1kplA:
undetectable		 4u9uA-1kplA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n31 L-CYSTEINE/CYSTINE
LYASE C-DES

(Synechocystis
sp. PCC 6714) 		PF00266
(Aminotran_5) 		4 GLY A 284
ALA A  35
GLY A 227
PRO A 228
 None
 0.94A 4u9uA-1n31A:
2.4		 4u9uA-1n31A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 GLY A 476
ALA A 475
GLY A 480
PRO A 432
 None
 0.93A 4u9uA-1nl3A:
2.2		 4u9uA-1nl3A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdb CYTOCHROME C NITRITE
REDUCTASE

(Sulfurospirillum
deleyianum) 		PF02335
(Cytochrom_C552) 		4 GLY A 115
ALA A 116
GLY A 123
PRO A 124
 None
 0.86A 4u9uA-1qdbA:
undetectable		 4u9uA-1qdbA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 ARG A 335
GLY A 110
ALA A 109
GLY A  82
 None
 0.94A 4u9uA-1t1eA:
undetectable		 4u9uA-1t1eA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 392
ALA A 287
GLY A 297
PRO A 298
 None
 0.91A 4u9uA-1ulqA:
undetectable		 4u9uA-1ulqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		4 ARG A 356
GLY A 344
GLY A  27
PRO A  28
 None
 0.94A 4u9uA-1vjoA:
undetectable		 4u9uA-1vjoA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Thermotoga
maritima) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 GLY A 294
ALA A 275
GLY A 296
PRO A 297
 None
 0.89A 4u9uA-1vrdA:
undetectable		 4u9uA-1vrdA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvt BETA-1,4-MANNANASE

(Cellulomonas
fimi) 		PF02156
(Glyco_hydro_26) 		4 GLY A 383
ALA A 384
GLY A 191
PRO A 190
 None
 0.92A 4u9uA-2bvtA:
undetectable		 4u9uA-2bvtA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 ARG A  28
GLY A   8
GLY A  96
PRO A  24
 None
 0.93A 4u9uA-2cevA:
4.0		 4u9uA-2cevA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY C 383
ALA C 277
GLY C 287
PRO C 288
 None
 0.92A 4u9uA-2d3tC:
undetectable		 4u9uA-2d3tC:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djs EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF00041
(fn3) 		4 GLY A  87
ALA A  86
GLY A   7
PRO A   8
 None
 0.83A 4u9uA-2djsA:
undetectable		 4u9uA-2djsA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dn7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE F

(Homo sapiens) 		PF00041
(fn3) 		4 GLY A  86
ALA A  85
GLY A   7
PRO A   8
 None
 0.88A 4u9uA-2dn7A:
undetectable		 4u9uA-2dn7A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drh 361AA LONG
HYPOTHETICAL
D-AMINOPEPTIDASE

(Pyrococcus
horikoshii) 		PF03576
(Peptidase_S58) 		4 ARG A  49
GLY A  37
GLY A  46
PRO A  47
 None
 0.87A 4u9uA-2drhA:
undetectable		 4u9uA-2drhA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e80 CYTOCHROME C-552

(Wolinella
succinogenes) 		PF02335
(Cytochrom_C552) 		4 GLY A 116
ALA A 117
GLY A 124
PRO A 125
 None
 0.86A 4u9uA-2e80A:
undetectable		 4u9uA-2e80A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		4 ARG A  37
GLY A  16
GLY A  21
PRO A  22
 None
 0.81A 4u9uA-2g04A:
2.8		 4u9uA-2g04A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g04 PROBABLE
FATTY-ACID-COA
RACEMASE FAR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		4 ARG A  37
GLY A  17
GLY A  21
PRO A  22
 None
 0.90A 4u9uA-2g04A:
2.8		 4u9uA-2g04A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gd2 PROBABLE
ALPHA-METHYLACYL-COA
RACEMASE MCR

(Mycobacterium
tuberculosis) 		PF02515
(CoA_transf_3) 		4 ARG A  35
GLY A  15
GLY A  19
PRO A  20
 None
 0.68A 4u9uA-2gd2A:
2.3		 4u9uA-2gd2A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 GLY A 213
ALA A 212
GLY A 217
PRO A 218
 None
 0.91A 4u9uA-2gsnA:
undetectable		 4u9uA-2gsnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 GLY A 188
ALA A 189
GLY A 184
PRO A 154
 None
None
PLP  A 400 ( 4.1A)
None
 0.92A 4u9uA-2isqA:
3.4		 4u9uA-2isqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 ARG A 781
GLY A 737
GLY A 747
PRO A 748
 SO4  A3024 (-2.9A)
None
None
None
 0.90A 4u9uA-2o2qA:
4.5		 4u9uA-2o2qA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT

(Porphyromonas
gingivalis) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 GLY A 287
ALA A 288
GLY A 384
PRO A 385
 None
FAD  A   1 ( 3.7A)
None
None
 0.40A 4u9uA-2r6hA:
41.7		 4u9uA-2r6hA:
56.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 GLY A 263
ALA A 432
GLY A 266
PRO A 267
 None
 0.90A 4u9uA-2r9hA:
undetectable		 4u9uA-2r9hA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf7 CYTOCHROME C-552

(Escherichia
coli) 		PF02335
(Cytochrom_C552) 		4 GLY A 108
ALA A 109
GLY A 116
PRO A 117
 None
 0.87A 4u9uA-2rf7A:
undetectable		 4u9uA-2rf7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 GLY A 112
ALA A 113
GLY A 108
PRO A  75
 None
None
GDP  A1317 (-3.4A)
None
 0.96A 4u9uA-2vawA:
5.0		 4u9uA-2vawA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 GLY A 424
ALA A 423
GLY A 428
PRO A 429
 None
 0.86A 4u9uA-2vosA:
undetectable		 4u9uA-2vosA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgg MICRONEME PROTEIN 2

(Toxoplasma
gondii) 		PF00092
(VWA) 		4 ARG A 173
ALA A 135
GLY A 109
PRO A 110
 None
 0.70A 4u9uA-2xggA:
3.7		 4u9uA-2xggA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ARG A 922
GLY A 899
GLY A 878
PRO A 879
 None
 0.87A 4u9uA-3ak5A:
2.0		 4u9uA-3ak5A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 ARG B 119
GLY B 147
ALA B 148
GLY B 117
 GOL  B 204 ( 4.0A)
None
GOL  B 204 (-4.2A)
None
 0.92A 4u9uA-3bn3B:
undetectable		 4u9uA-3bn3B:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B) 		4 GLY A 334
ALA A 333
GLY A 159
PRO A 160
 None
 0.77A 4u9uA-3chxA:
undetectable		 4u9uA-3chxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czp PUTATIVE
POLYPHOSPHATE KINASE
2

(Pseudomonas
aeruginosa) 		PF03976
(PPK2) 		4 ARG A 477
GLY A 313
ALA A 314
GLY A 310
 None
None
None
GOL  A 610 (-3.5A)
 0.86A 4u9uA-3czpA:
2.0		 4u9uA-3czpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czq PUTATIVE
POLYPHOSPHATE KINASE
2

(Sinorhizobium
meliloti) 		PF03976
(PPK2) 		4 ARG A 263
GLY A  99
ALA A 100
GLY A  96
 None
GOL  A 303 (-4.3A)
None
GOL  A 303 (-3.0A)
 0.95A 4u9uA-3czqA:
undetectable		 4u9uA-3czqA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF01063
(Aminotran_4) 		4 GLY A 174
ALA A 175
GLY A  30
PRO A  29
 None
 0.93A 4u9uA-3dtgA:
undetectable		 4u9uA-3dtgA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A

(Novosphingobium
aromaticivorans) 		PF02016
(Peptidase_S66) 		4 ARG A  55
GLY A  79
ALA A  80
GLY A  77
 None
None
None
SO4  A 276 ( 4.6A)
 0.85A 4u9uA-3g23A:
undetectable		 4u9uA-3g23A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hij DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
anthracis) 		PF00701
(DHDPS) 		4 GLY A 166
ALA A 165
GLY A 139
PRO A 138
 None
KPI  A 163 ( 4.9A)
None
None
 0.91A 4u9uA-3hijA:
undetectable		 4u9uA-3hijA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		4 GLY A 224
ALA A 223
GLY A  77
PRO A  78
 None
 0.91A 4u9uA-3kd8A:
undetectable		 4u9uA-3kd8A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgy BIFUNCTIONAL
DEAMINASE-REDUCTASE
DOMAIN PROTEIN

(Chloroflexus
aurantiacus) 		PF01872
(RibD_C) 		4 ARG A 117
ALA A  98
GLY A 119
PRO A 118
 None
 0.87A 4u9uA-3kgyA:
2.5		 4u9uA-3kgyA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A  66
ALA A  72
GLY A  76
PRO A  77
 None
 0.93A 4u9uA-3kw8A:
undetectable		 4u9uA-3kw8A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2b PROBABLE
MANGANASE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Clostridium
perfringens) 		PF00571
(CBS)
PF07085
(DRTGG) 		4 ARG A 158
GLY A 182
GLY A 163
PRO A 162
 None
 0.87A 4u9uA-3l2bA:
undetectable		 4u9uA-3l2bA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lwc UNCHARACTERIZED
PROTEIN

(Rhizobium
leguminosarum) 		PF06249
(EutQ) 		4 GLY A  80
ALA A 116
GLY A  94
PRO A  95
 None
 0.79A 4u9uA-3lwcA:
undetectable		 4u9uA-3lwcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		4 GLY A 188
ALA A 183
GLY A 112
PRO A 113
 None
 0.84A 4u9uA-3muqA:
undetectable		 4u9uA-3muqA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfb BETA-PEPTIDYL
AMINOPEPTIDASE

(Sphingosinicella
xenopeptidilytica) 		PF03576
(Peptidase_S58) 		4 ARG A  49
GLY A  37
GLY A  46
PRO A  47
 None
 0.92A 4u9uA-3nfbA:
undetectable		 4u9uA-3nfbA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		4 GLY A 112
ALA A 113
GLY A 109
PRO A 108
 None
None
LLP  A 252 ( 3.5A)
None
 0.95A 4u9uA-3nraA:
undetectable		 4u9uA-3nraA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oum TOXOFLAVIN-DEGRADING
ENZYME

(Paenibacillus
polymyxa) 		PF00903
(Glyoxalase) 		4 ARG A 187
GLY A 169
ALA A 168
GLY A 183
 None
 0.86A 4u9uA-3oumA:
undetectable		 4u9uA-3oumA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3quf EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 1

(Bifidobacterium
longum) 		PF13416
(SBP_bac_8) 		4 GLY A 148
ALA A 149
GLY A 274
PRO A 275
 None
 0.84A 4u9uA-3qufA:
undetectable		 4u9uA-3qufA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOB

(Methylocystis
sp. M) 		PF04744
(Monooxygenase_B) 		4 GLY A 323
ALA A 322
GLY A 148
PRO A 149
 None
 0.93A 4u9uA-3rfrA:
undetectable		 4u9uA-3rfrA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t57 UDP-N-ACETYLGLUCOSAM
INE
O-ACYLTRANSFERASE
DOMAIN-CONTAINING
PROTEIN

(Arabidopsis
thaliana) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 ARG A 250
GLY A 244
ALA A 247
GLY A 227
 None
 0.94A 4u9uA-3t57A:
undetectable		 4u9uA-3t57A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubr CYTOCHROME C-552

(Shewanella
oneidensis) 		PF02335
(Cytochrom_C552) 		4 GLY A 105
ALA A 106
GLY A 113
PRO A 114
 None
 0.87A 4u9uA-3ubrA:
undetectable		 4u9uA-3ubrA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 ARG A 461
GLY A 144
ALA A 143
GLY A 153
 None
TOX  A 140 ( 3.1A)
TOX  A 140 ( 4.1A)
None
 0.83A 4u9uA-3ut2A:
undetectable		 4u9uA-3ut2A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zk2 ATP SYNTHASE SUBUNIT
C

(Fusobacterium
nucleatum) 		PF00137
(ATP-synt_C) 		4 GLY A  25
ALA A  24
GLY A  27
PRO A  28
 None
 0.96A 4u9uA-3zk2A:
undetectable		 4u9uA-3zk2A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ARG A 476
GLY A  94
ALA A  95
GLY A  12
 None
 0.87A 4u9uA-4bc5A:
undetectable		 4u9uA-4bc5A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd5 ACETYL-COA
ACETYLTRANSFERASE

(Clostridioides
difficile) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 389
ALA A 286
GLY A 296
PRO A 297
 None
 0.95A 4u9uA-4dd5A:
undetectable		 4u9uA-4dd5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dia 2-PYRONE-4,6-DICARBA
XYLATE HYDROLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		4 GLY A  55
ALA A  54
GLY A  36
PRO A  37
 None
 0.88A 4u9uA-4diaA:
undetectable		 4u9uA-4diaA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		4 GLY A  37
ALA A  38
GLY A 221
PRO A 223
 None
GOL  A 402 (-3.7A)
None
None
 0.93A 4u9uA-4dqdA:
6.0		 4u9uA-4dqdA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eht ACTIVATOR OF
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF01869
(BcrAD_BadFG) 		4 GLY A  33
ALA A  12
GLY A  38
PRO A  39
 None
ADP  A 302 ( 3.3A)
None
None
 0.72A 4u9uA-4ehtA:
undetectable		 4u9uA-4ehtA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		4 GLY A 109
ALA A 110
GLY A 106
PRO A 105
 None
None
PLP  A 501 (-3.2A)
None
 0.90A 4u9uA-4emyA:
undetectable		 4u9uA-4emyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3w CYTIDINE DEAMINASE
CDD

(Mycobacterium
marinum) 		PF00383
(dCMP_cyt_deam_1) 		4 ARG A 114
GLY A 116
GLY A 101
PRO A 102
 None
 0.96A 4u9uA-4f3wA:
undetectable		 4u9uA-4f3wA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqu PUTATIVE GLUTATHIONE
TRANSFERASE

(Sphingobium
chlorophenolicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 GLY A 264
ALA A 267
GLY A 308
PRO A 307
 None
 0.86A 4u9uA-4fquA:
undetectable		 4u9uA-4fquA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2u ANCYLOSTOMA-SECRETED
PROTEIN-LIKE PROTEIN

(Ostertagia
ostertagi) 		PF00188
(CAP) 		4 GLY A  31
ALA A  30
GLY A  49
PRO A  50
 None
 0.91A 4u9uA-4g2uA:
undetectable		 4u9uA-4g2uA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLY A  66
ALA A  72
GLY A  76
PRO A  77
 None
 0.94A 4u9uA-4gybA:
undetectable		 4u9uA-4gybA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hz8 BETA-GLUCOSIDASE

(uncultured
bacterium) 		PF00232
(Glyco_hydro_1) 		4 GLY A 211
ALA A 210
GLY A 220
PRO A 219
 None
 0.87A 4u9uA-4hz8A:
undetectable		 4u9uA-4hz8A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 286
GLY A 256
ALA A 255
GLY A 258
 None
 0.83A 4u9uA-4izgA:
undetectable		 4u9uA-4izgA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ARG A 312
GLY A 140
ALA A 139
GLY A 314
 PLP  A 601 (-3.0A)
PLP  A 601 (-3.4A)
None
None
 0.92A 4u9uA-4je5A:
undetectable		 4u9uA-4je5A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 385
ALA A 282
GLY A 292
PRO A 293
 None
 0.96A 4u9uA-4o99A:
undetectable		 4u9uA-4o99A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oib INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 ARG A 119
GLY A 147
ALA A 148
GLY A 117
 None
 0.86A 4u9uA-4oibA:
undetectable		 4u9uA-4oibA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okr MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 ARG A 173
ALA A 135
GLY A 109
PRO A 110
 None
 0.70A 4u9uA-4okrA:
2.6		 4u9uA-4okrA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oku MICRONEMAL PROTEIN
MIC2

(Toxoplasma
gondii) 		PF00090
(TSP_1)
PF00092
(VWA) 		4 ARG A 173
ALA A 135
GLY A 109
PRO A 110
 None
 0.89A 4u9uA-4okuA:
2.7		 4u9uA-4okuA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqy (S)-IMINE REDUCTASE

(Streptomyces
sp. GF3546) 		PF03446
(NAD_binding_2) 		4 ARG A 101
GLY A 163
ALA A 162
PRO A  97
 None
 0.95A 4u9uA-4oqyA:
5.9		 4u9uA-4oqyA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio cholerae) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ARG F 229
GLY F 282
ALA F 283
GLY F 379
PRO F 380
 None
None
FAD  F 502 ( 4.0A)
None
None
 0.63A 4u9uA-4p6vF:
44.5		 4u9uA-4p6vF:
87.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfs SUBSTRATE BINDING
PRITEIN S

(Lactobacillus
brevis) 		PF12822
(ECF_trnsprt) 		4 GLY S  49
ALA S  48
GLY S  53
PRO S  54
 None
 0.95A 4u9uA-4rfsS:
undetectable		 4u9uA-4rfsS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfs SUBSTRATE BINDING
PRITEIN S

(Lactobacillus
brevis) 		PF12822
(ECF_trnsprt) 		4 GLY S 103
ALA S 102
GLY S  53
PRO S  54
 None
 0.96A 4u9uA-4rfsS:
undetectable		 4u9uA-4rfsS:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rus FISH-EGG LECTIN

(Cyprinus carpio) 		PF06462
(Hyd_WA) 		4 GLY A 175
ALA A 172
GLY A 129
PRO A 130
 None
 0.92A 4u9uA-4rusA:
undetectable		 4u9uA-4rusA:
22.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u9u NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio cholerae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ARG A 229
GLY A 282
ALA A 283
GLY A 379
PRO A 380
 ACT  A1502 ( 3.8A)
ACT  A1502 (-3.3A)
FAD  A1501 (-3.7A)
ACT  A1502 (-4.0A)
ACT  A1502 (-4.0A)
 0.02A 4u9uA-4u9uA:
49.2		 4u9uA-4u9uA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usx TRIMERIC
AUTOTRANSPORTER
ADHESIN

(Burkholderia
pseudomallei) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		4 ARG A 829
GLY A 790
ALA A 791
GLY A 774
 None
 0.92A 4u9uA-4usxA:
undetectable		 4u9uA-4usxA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens) 		PF03283
(PAE) 		4 ARG A 118
GLY A 222
ALA A 223
GLY A 219
 None
 0.94A 4u9uA-4uz1A:
undetectable		 4u9uA-4uz1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbh PROTEIN NOTUM
HOMOLOG

(Homo sapiens) 		PF03283
(PAE) 		4 ARG A 118
GLY A 222
ALA A 223
GLY A 219
 None
 0.95A 4u9uA-4wbhA:
undetectable		 4u9uA-4wbhA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyq RISC-LOADING COMPLEX
SUBUNIT TARBP2

(Homo sapiens) 		PF16482
(Staufen_C) 		4 GLY B 349
ALA B 352
GLY B 291
PRO B 292
 None
 0.79A 4u9uA-4wyqB:
undetectable		 4u9uA-4wyqB:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyr ACETYL-COA
ACETYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 384
ALA A 281
GLY A 291
PRO A 292
 None
 0.95A 4u9uA-4wyrA:
undetectable		 4u9uA-4wyrA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbz EVDO1

(Micromonospora
carbonacea) 		PF05721
(PhyH) 		4 ARG A  32
GLY A 155
ALA A 154
GLY A  35
 None
 0.95A 4u9uA-4xbzA:
undetectable		 4u9uA-4xbzA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8f HUMAN SAFFOLD
VIRUS-3 VP2

(Cardiovirus B) 		PF00073
(Rhv) 		4 ARG C 101
GLY C  90
ALA C  89
GLY C  93
 None
 0.94A 4u9uA-5a8fC:
undetectable		 4u9uA-5a8fC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7s CYSTEINE DESULFURASE

(Thermococcus
onnurineus) 		PF00266
(Aminotran_5) 		4 GLY A 276
ALA A 279
GLY A 220
PRO A 221
 None
 0.90A 4u9uA-5b7sA:
undetectable		 4u9uA-5b7sA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz4 BETA-KETOTHIOLASE

(Mycolicibacterium
smegmatis) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLY A 396
ALA A 290
GLY A 300
PRO A 301
 None
 0.92A 4u9uA-5bz4A:
undetectable		 4u9uA-5bz4A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgg UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 ARG A 185
GLY A 213
ALA A 214
GLY A 210
 None
 0.78A 4u9uA-5dggA:
undetectable		 4u9uA-5dggA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5di0 NATTERIN-LIKE
PROTEIN

(Danio rerio) 		PF03318
(ETX_MTX2) 		4 ARG A  52
GLY A  22
ALA A  27
GLY A 125
 PEG  A 409 (-3.8A)
None
PEG  A 410 ( 4.3A)
None
 0.87A 4u9uA-5di0A:
undetectable		 4u9uA-5di0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 4 ARG B 220
GLY B 219
GLY B 222
PRO B 221
 None
 0.94A 4u9uA-5fbhB:
4.6		 4u9uA-5fbhB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 4 GLY B 219
ALA B 213
GLY B 222
PRO B 221
 None
 0.88A 4u9uA-5fbhB:
4.6		 4u9uA-5fbhB:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 GLY L 109
ALA L 110
GLY L 114
PRO L 119
 None
 0.79A 4u9uA-5jfcL:
4.5		 4u9uA-5jfcL:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		4 GLY A 219
ALA A 213
GLY A 222
PRO A 221
 None
 0.88A 4u9uA-5k5tA:
3.0		 4u9uA-5k5tA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmi PLASTID RIBOSOMAL
PROTEIN UL10C

(Spinacia
oleracea) 		PF00466
(Ribosomal_L10) 		4 GLY I 163
ALA I 164
GLY I 172
PRO I 173
 None
 0.87A 4u9uA-5mmiI:
undetectable		 4u9uA-5mmiI:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my5 ABC TRANSPORTER
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Desulfovibrio
alaskensis) 		PF12849
(PBP_like_2) 		4 GLY A 165
ALA A 160
GLY A  88
PRO A  89
 None
 0.81A 4u9uA-5my5A:
undetectable		 4u9uA-5my5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 4 GLY A 194
ALA A 175
GLY A 196
PRO A 197
 None
 0.96A 4u9uA-5ou3A:
undetectable		 4u9uA-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc0 UNCHARACTERIZED
PROTEIN COG5400

(Brucella
abortus) 		PF06577
(DUF1134) 		4 ARG A 179
GLY A 177
ALA A 178
GLY A 181
 None
 0.95A 4u9uA-5uc0A:
undetectable		 4u9uA-5uc0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq4 MONOOXYGENASE

(Mycobacterium
tuberculosis) 		PF03992
(ABM) 		4 GLY A  14
ALA A  13
GLY A  16
PRO A  17
 None
 0.96A 4u9uA-5uq4A:
undetectable		 4u9uA-5uq4A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 GLY A 109
ALA A 110
GLY A 114
PRO A 119
 None
 0.86A 4u9uA-5vj7A:
2.8		 4u9uA-5vj7A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMS

(Legionella
pneumophila) 		PF12608
(T4bSS_IcmS) 		4 ARG A  85
GLY A  59
ALA A  60
GLY A  57
 None
 0.82A 4u9uA-5x1eA:
undetectable		 4u9uA-5x1eA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw5 TYROSINE-PROTEIN
PHOSPHATASE CDC14

(Saccharomyces
cerevisiae) 		PF00782
(DSPc)
PF14671
(DSPn) 		4 ARG A 128
GLY A 131
ALA A 130
GLY A 323
 None
 0.92A 4u9uA-5xw5A:
undetectable		 4u9uA-5xw5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7r IRON/ALPHA-KETOGLUTA
RATE-DEPENDENT
DIOXYGENASE ASQJ

(Aspergillus
nidulans) 		no annotation 4 ARG B 194
GLY B 170
ALA B 171
GLY B 213
 None
None
None
AKG  B 402 (-2.9A)
 0.86A 4u9uA-5y7rB:
undetectable		 4u9uA-5y7rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bg8 IG DOMAIN PROTEIN,
GROUP 2 DOMAIN
PROTEIN

(Shewanella
frigidimarina) 		no annotation 4 ARG A  42
GLY A  55
ALA A  54
GLY A  51
 None
 0.89A 4u9uA-6bg8A:
undetectable		 4u9uA-6bg8A:
undetectable