SIMILAR PATTERNS OF AMINO ACIDS FOR 4U5J_B_RXTB601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
TYR A 268
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.64A 4u5jB-1k9aA:
32.7		 4u5jB-1k9aA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.42A 4u5jB-1k9aA:
32.7		 4u5jB-1k9aA:
30.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 588
ALA A 606
TYR A 656
MET A 657
GLY A 660
LEU A 731
ASP A 742
 None
 0.62A 4u5jB-1lufA:
27.1		 4u5jB-1lufA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
VAL A 275
ALA A 288
MET A 337
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.48A 4u5jB-1opkA:
32.9		 4u5jB-1opkA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 None
 0.93A 4u5jB-1rjbA:
29.9		 4u5jB-1rjbA:
36.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
VAL A  86
ALA A  99
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.54A 4u5jB-1s9iA:
7.4		 4u5jB-1s9iA:
26.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
ALA A 621
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.56A 4u5jB-1t46A:
31.3		 4u5jB-1t46A:
35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 595
VAL A 603
ALA A 621
TYR A 672
LEU A 799
ASP A 810
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.74A 4u5jB-1t46A:
31.3		 4u5jB-1t46A:
35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
ALA A  36
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.63A 4u5jB-1zltA:
16.4		 4u5jB-1zltA:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
TYR X  84
MET X  85
GLY X  88
LEU X 137
ASP X 148
 STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 (-3.6A)
 0.68A 4u5jB-2dq7X:
37.2		 4u5jB-2dq7X:
84.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
ALA X  37
TYR X  84
MET X  85
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.6A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.43A 4u5jB-2dq7X:
37.2		 4u5jB-2dq7X:
84.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
TYR A 340
MET A 341
GLY A 344
LEU A 393
ASP A 404
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
H8H  A 534 (-4.2A)
 0.76A 4u5jB-2h8hA:
34.9		 4u5jB-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.24A 4u5jB-2h8hA:
34.9		 4u5jB-2h8hA:
52.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
VAL A 281
ALA A 293
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.52A 4u5jB-2hckA:
33.1		 4u5jB-2hckA:
51.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 643
ALA A 659
MET A 710
GLY A 713
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.52A 4u5jB-2henA:
27.0		 4u5jB-2henA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
ALA A 271
MET A 319
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 ( 3.7A)
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.49A 4u5jB-2hk5A:
29.7		 4u5jB-2hk5A:
67.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
VAL A 256
ALA A 269
MET A 318
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
None
GIN  A 600 (-4.7A)
 0.49A 4u5jB-2hz0A:
33.0		 4u5jB-2hz0A:
48.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
VAL A 259
ALA A 271
TYR A 318
MET A 319
GLY A 322
LEU A 371
ASP A 382
 None
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.87A 4u5jB-2og8A:
34.4		 4u5jB-2og8A:
67.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 588
VAL A 596
ALA A 614
TYR A 665
GLY A 669
LEU A 785
ASP A 796
 None
 0.71A 4u5jB-2ogvA:
29.4		 4u5jB-2ogvA:
34.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
VAL A  33
ALA A  46
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
None
None
ATP  A 381 ( 4.8A)
 0.50A 4u5jB-2phkA:
18.5		 4u5jB-2phkA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 LEU X  34
ALA X  53
TYR X 119
MET X 120
LEU X 179
ASP X 190
 HMD  X 400 ( 4.3A)
HMD  X 400 (-3.5A)
HMD  X 400 (-4.5A)
None
HMD  X 400 (-4.7A)
HMD  X 400 (-3.7A)
 0.78A 4u5jB-2pmoX:
23.0		 4u5jB-2pmoX:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 None
 0.53A 4u5jB-2psqA:
32.3		 4u5jB-2psqA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		7 VAL B  55
ALA B  67
TYR B 116
MET B 117
GLY B 120
LEU B 171
ASP B 182
 None
 0.75A 4u5jB-2qkwB:
25.6		 4u5jB-2qkwB:
30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 635
ALA A 651
MET A 702
GLY A 705
LEU A 753
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
PTR  A 701 ( 3.5A)
None
None
None
 0.36A 4u5jB-2qobA:
28.1		 4u5jB-2qobA:
39.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
TYR A 755
MET A 756
GLY A 759
LEU A 807
ASP A 818
 None
 0.44A 4u5jB-2r2pA:
34.3		 4u5jB-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 724
VAL A 732
ALA A 749
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.53A 4u5jB-2r4bA:
25.1		 4u5jB-2r4bA:
39.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  90
ALA A 103
TYR A 155
MET A 156
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 ( 4.9A)
None
None
ANP  A1480 ( 4.7A)
 0.72A 4u5jB-2v55A:
20.8		 4u5jB-2v55A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 226
VAL A 234
ALA A 247
MET A 304
GLY A 307
LEU A 354
ASP A 368
 XK9  A1511 (-3.8A)
XK9  A1511 (-4.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.6A)
 0.79A 4u5jB-2xk9A:
22.5		 4u5jB-2xk9A:
28.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
TYR A 701
MET A 702
GLY A 705
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
None
 0.44A 4u5jB-2xyuA:
27.6		 4u5jB-2xyuA:
43.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
VAL A 261
ALA A 273
MET A 322
GLY A 325
LEU A 374
ASP A 385
 None
 0.44A 4u5jB-2zv7A:
28.8		 4u5jB-2zv7A:
64.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.50A 4u5jB-3b2tA:
25.9		 4u5jB-3b2tA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 C4F  A   1 ( 3.9A)
None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
 0.73A 4u5jB-3c4fA:
24.9		 4u5jB-3c4fA:
36.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
TYR A 268
MET A 269
GLY A 272
LEU A 321
ASP A 332
 None
 0.63A 4u5jB-3d7uA:
27.8		 4u5jB-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
ALA A 220
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.42A 4u5jB-3d7uA:
27.8		 4u5jB-3d7uA:
42.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
VAL A 841
ALA A 859
TYR A 911
GLY A 915
LEU A1029
ASP A1040
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.9A)
None
None
None
 0.87A 4u5jB-3hngA:
30.0		 4u5jB-3hngA:
31.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  67
ALA A  80
TYR A 131
GLY A 135
LEU A 182
ASP A 193
 None
 0.75A 4u5jB-3iecA:
24.5		 4u5jB-3iecA:
27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
TYR A 715
MET A 716
GLY A 719
LEU A 767
 None
None
GOL  A 403 (-4.1A)
None
GOL  A 403 (-3.4A)
None
 0.51A 4u5jB-3kulA:
34.5		 4u5jB-3kulA:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.75A 4u5jB-3lm5A:
14.0		 4u5jB-3lm5A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  49
VAL A  57
ALA A  70
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
XFE  A 351 (-4.6A)
 0.65A 4u5jB-3mvjA:
23.3		 4u5jB-3mvjA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  88
VAL A  96
ALA A 109
TYR A 161
GLY A 165
LEU A 212
ASP A 223
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
None
None
None
SO4  A   5 ( 4.5A)
 0.87A 4u5jB-3nuuA:
25.4		 4u5jB-3nuuA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
VAL A 200
ALA A 213
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.8A)
 0.36A 4u5jB-3nyoA:
23.6		 4u5jB-3nyoA:
22.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 726
VAL A 734
ALA A 751
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.47A 4u5jB-3pp0A:
31.5		 4u5jB-3pp0A:
36.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
VAL A 431
ALA A 443
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.53A 4u5jB-3sxsA:
33.6		 4u5jB-3sxsA:
43.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.74A 4u5jB-3tt0A:
30.5		 4u5jB-3tt0A:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 LEU A 295
VAL A 303
ALA A 315
TYR A 365
MET A 366
GLY A 369
LEU A 423
 None
 0.69A 4u5jB-3ulzA:
23.8		 4u5jB-3ulzA:
28.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
VAL A 552
ALA A 570
TYR A 619
MET A 620
GLY A 623
LEU A 686
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.53A 4u5jB-3v5qA:
24.1		 4u5jB-3v5qA:
34.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
VAL A 147
ALA A 160
TYR A 212
GLY A 216
LEU A 263
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.4A)
N13  A 501 (-3.5A)
N13  A 501 (-4.5A)
 0.64A 4u5jB-3w18A:
16.7		 4u5jB-3w18A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
VAL A  83
ALA A  96
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.51A 4u5jB-3wigA:
23.0		 4u5jB-3wigA:
27.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
VAL A1959
ALA A1978
MET A2029
GLY A2032
LEU A2086
ASP A2102
 VGH  A3000 ( 4.4A)
None
VGH  A3000 (-3.4A)
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
None
 0.61A 4u5jB-3zbfA:
26.2		 4u5jB-3zbfA:
40.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
VAL A  91
ALA A 104
TYR A 156
GLY A 160
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-4.2A)
VX6  A 500 (-3.3A)
VX6  A 500 (-4.6A)
 0.43A 4u5jB-4af3A:
20.4		 4u5jB-4af3A:
23.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 560
VAL A 568
ALA A 586
TYR A 635
MET A 636
GLY A 639
LEU A 699
ASP A 710
 LTI  A1839 ( 4.2A)
None
LTI  A1839 (-3.3A)
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
None
 0.61A 4u5jB-4at3A:
30.0		 4u5jB-4at3A:
33.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 105
ALA A 121
MET A 172
GLY A 175
LEU A 223
ASP A 234
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 (-3.3A)
 0.58A 4u5jB-4aw5A:
27.7		 4u5jB-4aw5A:
42.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 LEU A 246
VAL A 254
ALA A 267
TYR A 320
GLY A 324
LEU A 371
 None
 0.76A 4u5jB-4c0tA:
24.1		 4u5jB-4c0tA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
ALA A  43
TYR A  95
GLY A  99
LEU A 146
 STU  A1550 (-4.3A)
None
STU  A1550 (-3.1A)
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.68A 4u5jB-4cfhA:
18.4		 4u5jB-4cfhA:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 653
TYR A 703
MET A 704
LEU A 773
ASP A 784
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
DI1  A1000 (-4.1A)
 0.90A 4u5jB-4ckrA:
29.9		 4u5jB-4ckrA:
35.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
ALA A 684
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
None
None
AGS  A1985 (-4.8A)
 0.58A 4u5jB-4crsA:
17.9		 4u5jB-4crsA:
24.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
VAL A 523
ALA A 541
TYR A 590
MET A 591
GLY A 594
LEU A 656
 None
 0.50A 4u5jB-4f0iA:
24.5		 4u5jB-4f0iA:
33.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
VAL A1130
ALA A1148
MET A1199
GLY A1202
LEU A1256
ASP A1270
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
0UV  A1501 ( 4.2A)
 0.59A 4u5jB-4fodA:
25.7		 4u5jB-4fodA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 LEU A 855
VAL A 863
ALA A 880
TYR A 931
GLY A 935
LEU A 983
 IZA  A2001 (-3.7A)
None
IZA  A2001 (-3.4A)
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.64A 4u5jB-4gl9A:
30.1		 4u5jB-4gl9A:
31.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 828
VAL A 836
ALA A 853
TYR A 904
GLY A 908
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.50A 4u5jB-4hviA:
26.3		 4u5jB-4hviA:
33.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
VAL A 140
ALA A 156
GLY A 211
LEU A 259
ASP A 270
 1G0  A 401 ( 4.5A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-4.6A)
None
 0.62A 4u5jB-4id7A:
25.2		 4u5jB-4id7A:
39.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  18
VAL A  26
ALA A  39
GLY A  95
LEU A 143
ASP A 154
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 ( 3.7A)
631  A 301 (-4.0A)
EDO  A 302 (-3.7A)
 0.59A 4u5jB-4jxfA:
11.2		 4u5jB-4jxfA:
29.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.45A 4u5jB-4k11A:
34.5		 4u5jB-4k11A:
94.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 478
ALA A 506
TYR A 557
GLY A 561
LEU A 624
ASP A 635
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
MG  A 802 ( 3.0A)
 0.68A 4u5jB-4k33A:
26.5		 4u5jB-4k33A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 478
VAL A 486
ALA A 506
TYR A 557
GLY A 561
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.65A 4u5jB-4k33A:
26.5		 4u5jB-4k33A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
VAL A 281
ALA A 293
TYR A 340
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 4.0A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.34A 4u5jB-4lggA:
37.3		 4u5jB-4lggA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.69A 4u5jB-4oliA:
28.7		 4u5jB-4oliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 627
VAL A 635
ALA A 648
TYR A 703
GLY A 707
LEU A 753
 None
 0.50A 4u5jB-4otdA:
23.7		 4u5jB-4otdA:
26.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 627
ALA A 644
TYR A 694
MET A 695
GLY A 698
LEU A 746
ASP A 757
 None
 0.51A 4u5jB-4p2kA:
34.1		 4u5jB-4p2kA:
43.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  24
VAL A  32
ALA A  45
TYR A  97
GLY A 101
LEU A 148
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 (-3.2A)
STU  A 601 (-4.4A)
STU  A 601 ( 3.8A)
STU  A 601 (-4.2A)
 0.77A 4u5jB-4rewA:
24.7		 4u5jB-4rewA:
21.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
None
 0.71A 4u5jB-4rt7A:
24.7		 4u5jB-4rt7A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
VAL A  22
ALA A  35
TYR A  83
MET A  84
GLY A  87
LEU A 136
ASP A 147
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
None
 0.50A 4u5jB-4ueuA:
35.5		 4u5jB-4ueuA:
62.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		6 LEU A 104
VAL A 112
ALA A 125
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
None
None
ATP  A 501 (-4.5A)
 0.66A 4u5jB-4wb7A:
23.2		 4u5jB-4wb7A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
VAL A 201
ALA A 214
MET A 267
GLY A 270
LEU A 321
ASP A 332
 ANW  A 601 ( 4.0A)
None
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
None
 0.82A 4u5jB-4wboA:
24.7		 4u5jB-4wboA:
19.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 LEU B 267
VAL B 275
ALA B 288
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.27A 4u5jB-4xeyB:
28.1		 4u5jB-4xeyB:
36.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
ALA A 428
TYR A 476
MET A 477
GLY A 480
LEU A 528
 None
 0.67A 4u5jB-4xi2A:
24.3		 4u5jB-4xi2A:
28.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
LYS A 430
TYR A 476
MET A 477
GLY A 480
LEU A 528
 None
 1.08A 4u5jB-4xi2A:
24.3		 4u5jB-4xi2A:
28.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
VAL A 624
ALA A 642
TYR A 693
GLY A 697
LEU A 818
ASP A 829
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
None
 0.72A 4u5jB-4xufA:
24.3		 4u5jB-4xufA:
38.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
VAL A 416
ALA A 428
TYR A 476
MET A 477
GLY A 480
LEU A 528
 746  A 702 (-3.8A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.29A 4u5jB-4y93A:
32.2		 4u5jB-4y93A:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
ALA A 214
MET A 267
LEU A 319
ASP A 330
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 (-3.6A)
None
None
AN2  A 601 (-3.0A)
 0.68A 4u5jB-4yhjA:
22.0		 4u5jB-4yhjA:
20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 484
VAL A 492
ALA A 512
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.58A 4u5jB-5a46A:
31.1		 4u5jB-5a46A:
32.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  99
VAL A 107
ALA A 120
GLY A 176
LEU A 223
ASP A 234
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
5U5  A 401 (-3.5A)
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
None
 0.59A 4u5jB-5eykA:
25.2		 4u5jB-5eykA:
22.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 903
VAL A 911
ALA A 928
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.45A 4u5jB-5f1zA:
29.3		 4u5jB-5f1zA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.52A 4u5jB-5fm2A:
33.4		 4u5jB-5fm2A:
31.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
VAL A 607
ALA A 625
TYR A 676
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.52A 4u5jB-5grnA:
25.4		 4u5jB-5grnA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 599
VAL A 607
ALA A 625
TYR A 676
LEU A 825
ASP A 836
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.79A 4u5jB-5grnA:
25.4		 4u5jB-5grnA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A1092
ALA A1108
TYR A1159
MET A1160
GLY A1163
ASP A1222
 63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
63K  A1401 (-3.5A)
None
63K  A1401 (-3.6A)
None
 0.58A 4u5jB-5horA:
9.1		 4u5jB-5horA:
36.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  57
VAL A  65
ALA A  77
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.55A 4u5jB-5i3oA:
24.0		 4u5jB-5i3oA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 718
VAL A 726
ALA A 743
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.39A 4u5jB-5j9zA:
32.4		 4u5jB-5j9zA:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A 897
ALA A 909
MET A 959
GLY A 962
LEU A1016
ASP A1027
 ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 (-3.4A)
 0.79A 4u5jB-5lpzA:
24.8		 4u5jB-5lpzA:
27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 593
VAL A 601
ALA A 617
MET A 674
GLY A 677
ASP A 741
 7AE  A1000 ( 3.9A)
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.4A)
 0.71A 4u5jB-5td2A:
21.5		 4u5jB-5td2A:
38.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 542
VAL A 550
ALA A 565
MET A 623
GLY A 626
ASP A 690
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
None
 0.71A 4u5jB-5u6bA:
30.3		 4u5jB-5u6bA:
37.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 106
ALA A 119
TYR A 171
MET A 172
GLY A 175
LEU A 221
ASP A 232
 None
 0.78A 4u5jB-5u7qA:
21.5		 4u5jB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
VAL A  32
ALA A  45
TYR A  97
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.59A 4u5jB-5w5jA:
19.4		 4u5jB-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 7 VAL A  36
ALA A  49
TYR A  98
MET A  99
GLY A 102
LEU A 150
ASP A 161
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.3A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
 0.72A 4u5jB-5wnmA:
28.0		 4u5jB-5wnmA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
VAL A 899
ALA A 917
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.58A 4u5jB-5wnoA:
28.8		 4u5jB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 6 LEU A  33
VAL A  41
ALA A  54
TYR A 101
GLY A 105
LEU A 153
 ANP  A 501 ( 3.8A)
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 ( 4.2A)
ANP  A 501 ( 4.0A)
ANP  A 501 (-4.6A)
 0.43A 4u5jB-6ao5A:
23.5		 4u5jB-6ao5A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 6 VAL A 205
ALA A 217
MET A 267
GLY A 270
LEU A 319
ASP A 330
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
None
 0.71A 4u5jB-6cz4A:
21.6		 4u5jB-6cz4A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 VAL A 200
ALA A 211
TYR A 264
MET A 265
GLY A 268
LEU A 318
ASP A 329
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.0A)
 0.69A 4u5jB-6f3dA:
25.3		 4u5jB-6f3dA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 LEU A 730
VAL A 738
ALA A 756
TYR A 806
GLY A 810
LEU A 881
 ADN  A1104 ( 4.0A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
ADN  A1104 ( 4.1A)
ADN  A1104 ( 3.8A)
ADN  A1104 (-4.3A)
 0.46A 4u5jB-6fekA:
32.4		 4u5jB-6fekA:
13.75