SIMILAR PATTERNS OF AMINO ACIDS FOR 4U5J_A_RXTA601
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | GLY A 204VAL A 209ALA A 220TYR A 268MET A 269GLY A 272ASN A 319LEU A 321ASP A 332 | None | 0.41A | 4u5jA-1k9aA:34.1 | 4u5jA-1k9aA:30.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | GLY A 207VAL A 209ALA A 220TYR A 268MET A 269GLY A 272ASN A 319LEU A 321ASP A 332 | None | 1.02A | 4u5jA-1k9aA:34.1 | 4u5jA-1k9aA:30.24 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1luf | MUSCLE-SPECIFICTYROSINE KINASERECEPTOR MUSK (Rattusnorvegicus) |
PF07714(Pkinase_Tyr) | 10 | GLY A 583VAL A 588ALA A 606TYR A 656MET A 657GLY A 660ASN A 729LEU A 731ALA A 741ASP A 742 | None | 0.92A | 4u5jA-1lufA:32.9 | 4u5jA-1lufA:32.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 267VAL A 275ALA A 288MET A 337GLY A 340ASN A 387LEU A 389ALA A 399 | P16 A 2 ( 4.2A)P16 A 2 (-4.5A)P16 A 2 (-3.4A)NoneP16 A 2 (-3.4A)NoneP16 A 2 (-4.4A)P16 A 2 (-3.5A) | 0.64A | 4u5jA-1opkA:33.6 | 4u5jA-1opkA:30.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8y | SR PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 8 | LEU A 164GLY A 167VAL A 172ALA A 185ASN A 299LEU A 301ALA A 549ASP A 550 | ADP A 810 ( 4.3A)ADP A 810 (-3.0A)ADP A 810 (-4.1A)ADP A 810 (-3.3A) MG A 809 ( 3.0A)ADP A 810 (-4.7A)NoneADP A 810 ( 3.0A) | 0.63A | 4u5jA-1q8yA:24.1 | 4u5jA-1q8yA:24.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1rjb | FL CYTOKINE RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 616VAL A 624ALA A 642TYR A 693GLY A 697ASN A 816LEU A 818ASP A 829 | None | 0.70A | 4u5jA-1rjbA:30.3 | 4u5jA-1rjbA:36.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 15VAL A 23ALA A 36TYR A 86GLY A 90ASN A 135LEU A 137ASP A 148 | HYM A 400 (-4.2A)HYM A 400 (-4.3A)HYM A 400 (-3.5A)HYM A 400 (-4.7A)NoneHYM A 400 (-4.2A)HYM A 400 (-4.5A)HYM A 400 (-3.9A) | 0.56A | 4u5jA-1zltA:12.8 | 4u5jA-1zltA:26.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2dq7 | PROTO-ONCOGENETYROSINE-PROTEINKINASE FYN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 11 | LEU X 17GLY X 20VAL X 25ALA X 37TYR X 84MET X 85GLY X 88ASN X 135LEU X 137ALA X 147ASP X 148 | STU X 902 (-3.8A)NoneSTU X 902 ( 4.8A)STU X 902 (-3.1A)STU X 902 (-4.6A)NoneSTU X 902 (-3.5A)STU X 902 ( 4.9A)STU X 902 (-4.4A)STU X 902 ( 4.1A)STU X 902 (-3.6A) | 0.58A | 4u5jA-2dq7X:38.9 | 4u5jA-2dq7X:84.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9g | MITOGEN-ACTIVATEDPROTEIN KINASE FUS3 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 8 | LEU A 19GLY A 22VAL A 27ALA A 40MET A 96ASN A 142LEU A 144ASP A 155 | ADP A 500 (-4.3A)ADP A 500 ( 4.6A)ADP A 500 (-4.3A)ADP A 500 ( 3.7A)None MG A 600 ( 2.7A)ADP A 500 (-4.3A)ADP A 500 ( 2.9A) | 0.65A | 4u5jA-2f9gA:15.7 | 4u5jA-2f9gA:27.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gcd | SERINE/THREONINE-PROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 8 | GLY A 37VAL A 42ALA A 55TYR A 107GLY A 110ASN A 156LEU A 158ASP A 169 | NoneSTU A 400 ( 4.8A)STU A 400 (-3.2A)STU A 400 (-4.5A)STU A 400 (-3.4A)STU A 400 (-4.4A)STU A 400 ( 4.6A)STU A 400 (-3.6A) | 0.70A | 4u5jA-2gcdA:27.7 | 4u5jA-2gcdA:30.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h8h | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 11 | LEU A 273GLY A 276VAL A 281ALA A 293TYR A 340MET A 341GLY A 344ASN A 391LEU A 393ALA A 403ASP A 404 | H8H A 534 (-3.8A)NoneH8H A 534 (-4.4A)H8H A 534 (-3.2A)H8H A 534 (-4.3A)NoneH8H A 534 (-3.3A)H8H A 534 ( 4.9A)H8H A 534 (-4.5A)H8H A 534 ( 4.0A)H8H A 534 (-4.2A) | 0.67A | 4u5jA-2h8hA:35.4 | 4u5jA-2h8hA:52.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | LEU A 273GLY A 276VAL A 281ALA A 293MET A 341GLY A 344ASN A 391LEU A 393ALA A 403 | QUE A 1 (-3.9A)NoneQUE A 1 ( 4.8A)QUE A 1 (-3.5A)NoneQUE A 1 (-3.0A)NoneQUE A 1 (-4.4A)QUE A 1 ( 4.5A) | 0.64A | 4u5jA-2hckA:33.6 | 4u5jA-2hckA:51.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hck | HEMATOPOETIC CELLKINASE HCK (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | LEU A 273GLY A 279VAL A 281ALA A 293MET A 341GLY A 344ASN A 391LEU A 393ALA A 403 | QUE A 1 (-3.9A)NoneQUE A 1 ( 4.8A)QUE A 1 (-3.5A)NoneQUE A 1 (-3.0A)NoneQUE A 1 (-4.4A)QUE A 1 ( 4.5A) | 1.16A | 4u5jA-2hckA:33.6 | 4u5jA-2hckA:51.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 251VAL A 259ALA A 271MET A 319GLY A 322ASN A 369LEU A 371ALA A 381ASP A 382 | 1BM A 499 ( 3.7A)1BM A 499 ( 4.8A)1BM A 499 (-3.6A)None1BM A 499 (-3.5A)1BM A 499 (-4.1A)1BM A 499 (-4.4A)1BM A 499 ( 3.7A)1BM A 499 (-4.4A) | 0.50A | 4u5jA-2hk5A:30.2 | 4u5jA-2hk5A:67.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hz0 | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 248GLY A 251VAL A 256ALA A 269MET A 318GLY A 321LEU A 370ALA A 380ASP A 381 | GIN A 600 ( 4.6A)NoneGIN A 600 ( 4.7A)GIN A 600 (-3.1A)NoneNoneGIN A 600 (-4.7A)GIN A 600 (-3.1A)GIN A 600 (-4.9A) | 0.77A | 4u5jA-2hz0A:34.5 | 4u5jA-2hz0A:48.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i0e | PROTEIN KINASEC-BETA II (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | LEU A 348GLY A 351VAL A 356ALA A 369TYR A 422ASN A 471ALA A 483ASP A 484 | PDS A 901 (-3.9A)NonePDS A 901 (-4.2A)PDS A 901 (-3.3A)PDS A 901 (-4.7A)PDS A 901 (-4.3A)PDS A 901 (-3.4A)PDS A 901 (-3.6A) | 0.70A | 4u5jA-2i0eA:14.5 | 4u5jA-2i0eA:25.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 588VAL A 596ALA A 614TYR A 665GLY A 669ASN A 783LEU A 785ASP A 796 | None | 0.56A | 4u5jA-2ogvA:30.0 | 4u5jA-2ogvA:34.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2phk | PHOSPHORYLASE KINASE (Oryctolaguscuniculus) |
PF00069(Pkinase) | 9 | LEU A 25GLY A 28VAL A 33ALA A 46MET A 106GLY A 109ASN A 154LEU A 156ASP A 167 | ATP A 381 ( 4.3A)ATP A 381 (-3.0A)ATP A 381 (-4.1A)ATP A 381 (-3.5A)NoneNone MN A 383 ( 2.7A)ATP A 381 ( 4.8A) MN A 382 (-2.0A) | 0.55A | 4u5jA-2phkA:18.6 | 4u5jA-2phkA:26.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pmo | SER/THR PROTEINKINASE (Plasmodiumfalciparum) |
PF00069(Pkinase) | 8 | LEU X 34GLY X 37ALA X 53TYR X 119MET X 120ASN X 177LEU X 179ASP X 190 | HMD X 400 ( 4.3A)NoneHMD X 400 (-3.5A)HMD X 400 (-4.5A)NoneHMD X 400 (-4.6A)HMD X 400 (-4.7A)HMD X 400 (-3.7A) | 0.49A | 4u5jA-2pmoX:23.8 | 4u5jA-2pmoX:23.20 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2psq | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 487GLY A 493VAL A 495ALA A 515TYR A 566GLY A 570ASN A 631LEU A 633ALA A 643 | None | 0.85A | 4u5jA-2psqA:33.9 | 4u5jA-2psqA:32.17 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2qkw | PROTEIN KINASE (Solanumpimpinellifolium) |
PF07714(Pkinase_Tyr) | 9 | GLY B 50VAL B 55ALA B 67TYR B 116MET B 117GLY B 120ASN B 169LEU B 171ASP B 182 | None | 0.54A | 4u5jA-2qkwB:26.5 | 4u5jA-2qkwB:30.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r2p | EPHRIN TYPE-ARECEPTOR 5 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 8 | VAL A 689ALA A 705TYR A 755MET A 756GLY A 759ASN A 805LEU A 807ASP A 818 | None | 0.53A | 4u5jA-2r2pA:35.1 | 4u5jA-2r2pA:43.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v55 | RHO-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 10 | GLY A 85VAL A 90ALA A 103TYR A 155MET A 156GLY A 159ASN A 203LEU A 205ALA A 215ASP A 216 | ANP A1480 ( 3.8A)NoneANP A1480 ( 3.9A)ANP A1480 ( 4.9A)NoneNone MG A1481 (-3.5A)ANP A1480 ( 4.7A)ANP A1480 ( 4.1A)ANP A1480 (-3.5A) | 0.72A | 4u5jA-2v55A:21.2 | 4u5jA-2v55A:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vd5 | DMPK PROTEIN (Homo sapiens) |
PF00069(Pkinase) | 8 | GLY A 80VAL A 85ALA A 98TYR A 150ASN A 200LEU A 202ALA A 212ASP A 213 | NoneBI8 A1417 ( 4.7A)BI8 A1417 ( 3.8A)BI8 A1417 (-4.8A)BI8 A1417 (-3.6A)BI8 A1417 (-4.8A)BI8 A1417 ( 4.1A)BI8 A1417 (-3.8A) | 0.62A | 4u5jA-2vd5A:23.1 | 4u5jA-2vd5A:25.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xik | SERINE/THREONINEPROTEIN KINASE 25 (Homo sapiens) |
PF00069(Pkinase) | 8 | VAL A 34ALA A 47TYR A 97GLY A 101ASN A 145LEU A 147ALA A 157ASP A 158 | J60 A1294 ( 4.9A)J60 A1294 (-3.3A)J60 A1294 (-4.5A)J60 A1294 ( 3.8A)NoneJ60 A1294 (-4.8A)J60 A1294 ( 4.2A)J60 A1294 ( 4.6A) | 0.49A | 4u5jA-2xikA:21.1 | 4u5jA-2xikA:29.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xk9 | CHECKPOINT KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 226GLY A 229VAL A 234ALA A 247MET A 304GLY A 307ASN A 352LEU A 354 | XK9 A1511 (-3.8A)NoneXK9 A1511 (-4.8A)XK9 A1511 ( 4.1A)NoneXK9 A1511 ( 3.7A)NoneXK9 A1511 (-4.6A) | 0.70A | 4u5jA-2xk9A:22.8 | 4u5jA-2xk9A:28.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 253VAL A 261ALA A 273MET A 322GLY A 325ASN A 372LEU A 374ALA A 384ASP A 385 | None | 0.51A | 4u5jA-2zv7A:37.6 | 4u5jA-2zv7A:64.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b2t | FIBROBLAST GROWTHFACTOR RECEPTOR 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 487GLY A 490VAL A 495ALA A 515TYR A 566GLY A 570ASN A 631LEU A 633ALA A 643 | M33 A1996 (-4.0A)M33 A1996 (-3.0A)M33 A1996 ( 4.7A)M33 A1996 (-3.3A)M33 A1996 ( 4.7A)M33 A1996 ( 4.8A)NoneM33 A1996 (-4.5A)None | 0.45A | 4u5jA-3b2tA:26.1 | 4u5jA-3b2tA:36.83 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3c4f | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 484VAL A 492ALA A 512TYR A 563GLY A 567ASN A 628LEU A 630ALA A 640 | C4F A 1 ( 3.9A)NoneC4F A 1 (-3.3A)NoneNoneNoneC4F A 1 (-4.6A)C4F A 1 (-3.6A) | 0.65A | 4u5jA-3c4fA:30.6 | 4u5jA-3c4fA:36.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | GLY A 204VAL A 209ALA A 220TYR A 268MET A 269GLY A 272ASN A 319LEU A 321ASP A 332 | None | 0.41A | 4u5jA-3d7uA:28.4 | 4u5jA-3d7uA:42.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | GLY A 207VAL A 209ALA A 220TYR A 268MET A 269GLY A 272ASN A 319LEU A 321ASP A 332 | None | 1.02A | 4u5jA-3d7uA:28.4 | 4u5jA-3d7uA:42.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iec | SERINE/THREONINE-PROTEIN KINASE MARK2 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 8 | VAL A 67ALA A 80TYR A 131GLY A 135ASN A 180LEU A 182ALA A 192ASP A 193 | None | 0.74A | 4u5jA-3iecA:25.0 | 4u5jA-3iecA:27.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 8 | VAL A 649ALA A 665TYR A 715MET A 716GLY A 719ASN A 765LEU A 767ASP A 778 | NoneNoneGOL A 403 (-4.1A)NoneGOL A 403 (-3.4A)NoneNoneNone | 0.68A | 4u5jA-3kulA:28.9 | 4u5jA-3kulA:38.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm5 | SERINE/THREONINE-PROTEIN KINASE 17B (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 39GLY A 42VAL A 47ALA A 60TYR A 112GLY A 116ASN A 163LEU A 165 | QUE A 1 ( 3.8A)NoneQUE A 1 ( 4.6A)QUE A 1 (-3.2A)QUE A 1 (-4.9A)NoneNoneNone | 0.74A | 4u5jA-3lm5A:26.8 | 4u5jA-3lm5A:27.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mvj | CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase) | 9 | LEU A 49GLY A 52VAL A 57ALA A 70TYR A 122GLY A 126ASN A 171LEU A 173ASP A 184 | XFE A 351 (-4.2A)NoneXFE A 351 ( 4.5A)XFE A 351 (-3.2A)NoneNoneNoneXFE A 351 (-4.6A)None | 0.86A | 4u5jA-3mvjA:24.3 | 4u5jA-3mvjA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | VAL A 216ALA A 227TYR A 279GLY A 283ASN A 335LEU A 337ALA A 347ASP A 348 | LDN A 600 (-4.5A)LDN A 600 (-3.2A)LDN A 600 (-4.7A)LDN A 600 (-3.3A)LDN A 600 (-4.5A)LDN A 600 (-4.6A)LDN A 600 ( 3.8A)None | 0.72A | 4u5jA-3my0A:27.6 | 4u5jA-3my0A:27.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3niz | RHODANESE FAMILYPROTEIN (Cryptosporidiumparvum) |
PF00069(Pkinase) | 8 | GLY A 32VAL A 37ALA A 49MET A 101ASN A 149LEU A 151ALA A 161ASP A 162 | ADP A 314 (-3.0A)ADP A 314 (-4.0A)ADP A 314 (-3.5A)None MG A 312 ( 2.9A)ADP A 314 (-4.6A)None MG A 312 ( 3.3A) | 0.48A | 4u5jA-3nizA:26.6 | 4u5jA-3nizA:25.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 9 | LEU A 88GLY A 91VAL A 96ALA A 109TYR A 161GLY A 165ASN A 210LEU A 212ASP A 223 | JOZ A 361 (-4.1A)SO4 A 5 ( 4.4A)JOZ A 361 ( 4.7A)JOZ A 361 (-3.4A)NoneNoneNoneNoneSO4 A 5 ( 4.5A) | 0.77A | 4u5jA-3nuuA:26.2 | 4u5jA-3nuuA:26.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyo | G PROTEIN-COUPLEDRECEPTOR KINASE 6 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 8 | LEU A 192VAL A 200ALA A 213MET A 266GLY A 269ASN A 316LEU A 318ASP A 329 | AMP A 577 ( 4.3A)AMP A 577 (-4.3A)AMP A 577 (-3.4A)NoneNoneAMP A 577 (-4.2A)AMP A 577 (-4.8A)AMP A 577 (-4.0A) | 0.50A | 4u5jA-3nyoA:18.2 | 4u5jA-3nyoA:22.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3pls | MACROPHAGE-STIMULATING PROTEIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | GLY A1091VAL A1096ALA A1112TYR A1163MET A1164GLY A1167ASN A1213ALA A1225 | ANP A1358 (-3.4A)ANP A1358 (-4.4A)ANP A1358 ( 3.8A)ANP A1358 (-4.3A)NoneNone MG A 1 ( 2.9A)None | 0.67A | 4u5jA-3plsA:30.4 | 4u5jA-3plsA:37.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 8 | GLY A 560VAL A 565ALA A 576TYR A 627GLY A 631ASN A 681LEU A 683ASP A 694 | NoneSTU A 1 (-4.9A)STU A 1 (-3.3A)STU A 1 (-4.4A)STU A 1 (-3.2A)STU A 1 (-4.6A)STU A 1 (-4.3A)STU A 1 (-3.5A) | 0.45A | 4u5jA-3ppzA:32.3 | 4u5jA-3ppzA:32.81 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3tt0 | BASIC FIBROBLASTGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 484GLY A 487VAL A 492ALA A 512TYR A 563GLY A 567ASN A 628LEU A 630ALA A 640 | 07J A 1 ( 4.3A)None07J A 1 (-4.0A)07J A 1 (-3.5A)07J A 1 (-4.7A)07J A 1 (-3.7A)None07J A 1 ( 4.4A)07J A 1 (-3.2A) | 0.75A | 4u5jA-3tt0A:30.7 | 4u5jA-3tt0A:33.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txo | PROTEIN KINASE C ETATYPE (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | LEU A 361GLY A 364VAL A 369ALA A 382ASN A 484LEU A 486ALA A 496ASP A 497 | 07U A 1 ( 4.8A)None07U A 1 (-4.8A)07U A 1 (-3.3A)None07U A 1 (-4.3A)07U A 1 ( 4.0A)07U A 1 (-3.6A) | 0.71A | 4u5jA-3txoA:15.4 | 4u5jA-3txoA:24.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3v5q | NT-3 GROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 544VAL A 552ALA A 570TYR A 619MET A 620GLY A 623ASN A 684LEU A 686 | 0F4 A 902 ( 4.2A)None0F4 A 902 (-3.2A)0F4 A 902 (-4.2A)None0F4 A 902 (-3.4A)None0F4 A 902 (-4.5A) | 0.50A | 4u5jA-3v5qA:25.3 | 4u5jA-3v5qA:34.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w18 | AURORA KINASE A (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 139GLY A 142VAL A 147ALA A 160TYR A 212ASN A 261LEU A 263ALA A 273 | N13 A 501 (-3.7A)NoneN13 A 501 ( 4.7A)N13 A 501 ( 4.1A)N13 A 501 (-4.4A)NoneN13 A 501 (-4.5A)N13 A 501 ( 3.8A) | 0.57A | 4u5jA-3w18A:16.8 | 4u5jA-3w18A:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w18 | AURORA KINASE A (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 139VAL A 147ALA A 160TYR A 212GLY A 216ASN A 261LEU A 263ALA A 273 | N13 A 501 (-3.7A)N13 A 501 ( 4.7A)N13 A 501 ( 4.1A)N13 A 501 (-4.4A)N13 A 501 (-3.5A)NoneN13 A 501 (-4.5A)N13 A 501 ( 3.8A) | 0.59A | 4u5jA-3w18A:16.8 | 4u5jA-3w18A:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wig | DUAL SPECIFICITYMITOGEN-ACTIVATEDPROTEIN KINASEKINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 75GLY A 78VAL A 83ALA A 96MET A 147GLY A 150ASN A 196LEU A 198 | ANP A 401 (-3.8A)ANP A 401 (-3.3A)ANP A 401 ( 4.3A)ANP A 401 (-3.2A)NoneANP A 401 ( 4.3A) MG A 402 ( 2.9A)ANP A 401 (-4.8A) | 0.74A | 4u5jA-3wigA:23.3 | 4u5jA-3wigA:27.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A1951VAL A1959ALA A1978MET A2029GLY A2032ASN A2084LEU A2086ASP A2102 | VGH A3000 ( 4.4A)NoneVGH A3000 (-3.4A)NoneVGH A3000 (-3.5A)NoneVGH A3000 (-4.3A)None | 0.65A | 4u5jA-3zbfA:26.2 | 4u5jA-3zbfA:40.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af3 | AURORA KINASE B (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 83VAL A 91ALA A 104TYR A 156GLY A 160ASN A 205LEU A 207ALA A 217 | VX6 A 500 (-3.8A)VX6 A 500 ( 4.8A)VX6 A 500 (-3.4A)VX6 A 500 (-4.2A)VX6 A 500 (-3.3A)NoneVX6 A 500 (-4.6A)VX6 A 500 ( 4.2A) | 0.64A | 4u5jA-4af3A:20.6 | 4u5jA-4af3A:23.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4at3 | BDNF/NT-3 GROWTHFACTORS RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 560VAL A 568ALA A 586TYR A 635MET A 636GLY A 639ASN A 697LEU A 699ASP A 710 | LTI A1839 ( 4.2A)NoneLTI A1839 (-3.3A)LTI A1839 (-4.7A)NoneLTI A1839 (-3.4A)NoneLTI A1839 (-4.2A)None | 0.60A | 4u5jA-4at3A:30.2 | 4u5jA-4at3A:33.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aw2 | SERINE/THREONINE-PROTEIN KINASE MRCKALPHA (Rattusnorvegicus) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | GLY A 86VAL A 91ALA A 104TYR A 156ASN A 206LEU A 208ALA A 218ASP A 219 | NoneNoneEDO A1420 (-3.4A)EDO A1420 (-4.9A)NoneEDO A1420 ( 4.8A)NoneNone | 0.73A | 4u5jA-4aw2A:22.6 | 4u5jA-4aw2A:25.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c02 | ACTIVIN RECEPTORTYPE-1 (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 8 | GLY A 217VAL A 222ALA A 233TYR A 285GLY A 289ASN A 341LEU A 343ALA A 353 | NoneTAK A1507 (-4.7A)TAK A1507 (-3.3A)TAK A1507 ( 4.6A)TAK A1507 (-3.5A)NoneTAK A1507 (-4.7A)TAK A1507 ( 4.2A) | 0.69A | 4u5jA-4c02A:27.6 | 4u5jA-4c02A:28.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cfh | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-1 (Rattusnorvegicus) |
PF00069(Pkinase)PF16579(AdenylateSensor) | 8 | LEU A 22VAL A 30ALA A 43TYR A 95GLY A 99ASN A 144LEU A 146ALA A 156 | STU A1550 (-4.3A)NoneSTU A1550 (-3.1A)STU A1550 (-4.5A)STU A1550 (-3.4A)STU A1550 (-4.3A)STU A1550 (-4.3A)STU A1550 ( 3.8A) | 0.69A | 4u5jA-4cfhA:25.8 | 4u5jA-4cfhA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cfh | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-1 (Rattusnorvegicus) |
PF00069(Pkinase)PF16579(AdenylateSensor) | 8 | VAL A 30ALA A 43TYR A 95GLY A 99ASN A 144LEU A 146ALA A 156ASP A 157 | NoneSTU A1550 (-3.1A)STU A1550 (-4.5A)STU A1550 (-3.4A)STU A1550 (-4.3A)STU A1550 (-4.3A)STU A1550 ( 3.8A)STU A1550 (-3.6A) | 0.67A | 4u5jA-4cfhA:25.8 | 4u5jA-4cfhA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | LEU A 663GLY A 666VAL A 671ALA A 684TYR A 739GLY A 743LEU A 789ASP A 800 | AGS A1985 (-4.2A)AGS A1985 (-2.9A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)NoneNoneAGS A1985 (-4.8A)AGS A1985 ( 3.3A) | 0.70A | 4u5jA-4crsA:17.9 | 4u5jA-4crsA:24.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4crs | SERINE/THREONINE-PROTEIN KINASE N2 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 9 | LEU A 663VAL A 671ALA A 684TYR A 739GLY A 743ASN A 787LEU A 789ALA A 799ASP A 800 | AGS A1985 (-4.2A)AGS A1985 (-4.6A)AGS A1985 (-3.5A)NoneNone MG A1986 ( 3.2A)AGS A1985 (-4.8A)AGS A1985 ( 4.5A)AGS A1985 ( 3.3A) | 0.56A | 4u5jA-4crsA:17.9 | 4u5jA-4crsA:24.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4f0i | HIGH AFFINITY NERVEGROWTH FACTORRECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 515VAL A 523ALA A 541TYR A 590MET A 591GLY A 594ASN A 654LEU A 656ASP A 667 | None | 0.77A | 4u5jA-4f0iA:24.5 | 4u5jA-4f0iA:33.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fod | ALK TYROSINE KINASERECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A1122VAL A1130ALA A1148MET A1199GLY A1202ASN A1254LEU A1256ASP A1270 | 0UV A1501 (-3.8A)0UV A1501 (-4.5A)0UV A1501 (-3.4A)None0UV A1501 (-3.6A)0UV A1501 ( 4.9A)0UV A1501 (-4.6A)0UV A1501 ( 4.2A) | 0.48A | 4u5jA-4fodA:25.6 | 4u5jA-4fodA:33.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gl9 | TYROSINE-PROTEINKINASE (Mus musculus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 855GLY A 861VAL A 863ALA A 880TYR A 931GLY A 935ASN A 981LEU A 983ASP A 994 | IZA A2001 (-3.7A)NoneNoneIZA A2001 (-3.4A)NoneIZA A2001 (-3.3A)IZA A2001 ( 4.7A)IZA A2001 ( 4.7A)IZA A2001 ( 4.5A) | 1.28A | 4u5jA-4gl9A:31.3 | 4u5jA-4gl9A:31.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 828GLY A 831VAL A 836ALA A 853TYR A 904GLY A 908ASN A 954LEU A 956ALA A 966ASP A 967 | 19S A1201 (-3.9A)19S A1201 ( 4.3A)19S A1201 (-4.4A)19S A1201 (-3.3A)19S A1201 (-4.7A)19S A1201 ( 3.8A)None19S A1201 (-4.5A)19S A1201 ( 4.1A)19S A1201 ( 4.1A) | 0.73A | 4u5jA-4hviA:26.1 | 4u5jA-4hviA:33.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hvi | TYROSINE-PROTEINKINASE JAK3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 9 | LEU A 828GLY A 834VAL A 836ALA A 853TYR A 904ASN A 954LEU A 956ALA A 966ASP A 967 | 19S A1201 (-3.9A)19S A1201 ( 4.9A)19S A1201 (-4.4A)19S A1201 (-3.3A)19S A1201 (-4.7A)None19S A1201 (-4.5A)19S A1201 ( 4.1A)19S A1201 ( 4.1A) | 1.25A | 4u5jA-4hviA:26.1 | 4u5jA-4hviA:33.54 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4id7 | ACTIVATED CDC42KINASE 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 132GLY A 135VAL A 140ALA A 156GLY A 211ASN A 257LEU A 259ASP A 270 | 1G0 A 401 ( 4.5A)None1G0 A 401 (-4.4A)1G0 A 401 (-3.6A)1G0 A 401 ( 4.5A)None1G0 A 401 (-4.6A)None | 0.67A | 4u5jA-4id7A:32.7 | 4u5jA-4id7A:39.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 10 | LEU A 273GLY A 276VAL A 281ALA A 293TYR A 340MET A 341GLY A 344ASN A 391LEU A 393ALA A 403 | 0J9 A 601 (-4.0A)None0J9 A 601 (-4.4A)0J9 A 601 (-3.3A)0J9 A 601 ( 4.7A)None0J9 A 601 ( 4.1A)None0J9 A 601 (-4.5A)0J9 A 601 (-3.5A) | 0.49A | 4u5jA-4k11A:35.1 | 4u5jA-4k11A:94.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k11 | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Homo sapiens) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 9 | LEU A 273GLY A 279VAL A 281ALA A 293TYR A 340MET A 341ASN A 391LEU A 393ALA A 403 | 0J9 A 601 (-4.0A)None0J9 A 601 (-4.4A)0J9 A 601 (-3.3A)0J9 A 601 ( 4.7A)NoneNone0J9 A 601 (-4.5A)0J9 A 601 (-3.5A) | 1.03A | 4u5jA-4k11A:35.1 | 4u5jA-4k11A:94.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 478GLY A 481VAL A 486ALA A 506TYR A 557GLY A 561ASN A 622LEU A 624ALA A 634ASP A 635 | ACP A 801 (-3.8A)ACP A 801 (-3.6A)ACP A 801 (-4.2A)ACP A 801 (-3.3A)NoneACP A 801 ( 4.6A) MG A 802 ( 2.4A)ACP A 801 (-4.4A)None MG A 802 ( 3.0A) | 0.60A | 4u5jA-4k33A:26.9 | 4u5jA-4k33A:35.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4k33 | FIBROBLAST GROWTHFACTOR RECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | LEU A 478GLY A 484VAL A 486ALA A 506TYR A 557GLY A 561ASN A 622LEU A 624ALA A 634ASP A 635 | ACP A 801 (-3.8A)ACP A 801 (-3.6A)ACP A 801 (-4.2A)ACP A 801 (-3.3A)NoneACP A 801 ( 4.6A) MG A 802 ( 2.4A)ACP A 801 (-4.4A)None MG A 802 ( 3.0A) | 0.86A | 4u5jA-4k33A:26.9 | 4u5jA-4k33A:35.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 273GLY A 276VAL A 281ALA A 293TYR A 340MET A 341GLY A 344ASN A 391LEU A 393 | VGG A 601 (-3.2A)NoneVGG A 601 ( 3.5A)VGG A 601 (-3.5A)VGG A 601 ( 4.0A)NoneVGG A 601 ( 3.2A)NoneVGG A 601 (-4.5A) | 0.56A | 4u5jA-4lggA:37.9 | 4u5jA-4lggA:99.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lgg | PROTO-ONCOGENETYROSINE-PROTEINKINASE SRC (Gallus gallus) |
PF07714(Pkinase_Tyr) | 9 | LEU A 273VAL A 281ALA A 293TYR A 340MET A 341GLY A 344ASN A 391LEU A 393ALA A 403 | VGG A 601 (-3.2A)VGG A 601 ( 3.5A)VGG A 601 (-3.5A)VGG A 601 ( 4.0A)NoneVGG A 601 ( 3.2A)NoneVGG A 601 (-4.5A)VGG A 601 ( 4.2A) | 0.43A | 4u5jA-4lggA:37.9 | 4u5jA-4lggA:99.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4o27 | SERINE/THREONINE-PROTEIN KINASE 24 (Homo sapiens) |
PF00069(Pkinase) | 9 | GLY B 33VAL B 38ALA B 51TYR B 101GLY B 105ASN B 149LEU B 151ALA B 161ASP B 162 | ADP B 500 (-3.3A)ADP B 500 (-4.5A)ADP B 500 (-3.3A)ADP B 500 ( 4.7A)None MN B 501 ( 3.1A)ADP B 500 (-4.7A)NoneADP B 500 ( 3.4A) | 0.60A | 4u5jA-4o27B:20.5 | 4u5jA-4o27B:30.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 10 | LEU A 627GLY A 630VAL A 635ALA A 648TYR A 703GLY A 707ASN A 751LEU A 753ALA A 763ASP A 764 | None | 0.89A | 4u5jA-4otdA:24.3 | 4u5jA-4otdA:26.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q9z | HUMAN PROTEIN KINASEC THETA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 8 | LEU A 386GLY A 389VAL A 394ALA A 407TYR A 460ASN A 509LEU A 511ALA A 521 | PZW A 801 (-3.9A)NonePZW A 801 (-4.6A)PZW A 801 (-3.5A)NonePZW A 801 (-4.4A)PZW A 801 (-4.8A)PZW A 801 ( 4.6A) | 0.54A | 4u5jA-4q9zA:23.0 | 4u5jA-4q9zA:24.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rt7 | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 616VAL A 624ALA A 642TYR A 693GLY A 697ASN A 816LEU A 818ASP A 829 | P30 A1001 (-3.8A)NoneP30 A1001 (-3.4A)P30 A1001 (-4.1A)P30 A1001 (-3.4A)NoneP30 A1001 (-4.6A)None | 0.66A | 4u5jA-4rt7A:24.8 | 4u5jA-4rt7A:32.42 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 10 | LEU A 14VAL A 22ALA A 35TYR A 83MET A 84GLY A 87ASN A 134LEU A 136ALA A 146ASP A 147 | ACP A1264 ( 4.5A)ACP A1264 (-4.7A)ACP A1264 (-2.9A)ACP A1264 ( 4.5A)NoneACP A1264 (-3.5A)NoneACP A1264 ( 4.8A)NoneNone | 0.53A | 4u5jA-4ueuA:36.6 | 4u5jA-4ueuA:62.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 8 | LEU A 104GLY A 107VAL A 112ALA A 125TYR A 177GLY A 181LEU A 228ASP A 239 | ATP A 501 ( 4.3A)ATP A 501 (-3.2A)ATP A 501 (-4.0A)ATP A 501 (-3.4A)NoneNoneATP A 501 (-4.5A) ZN A 503 (-1.9A) | 0.75A | 4u5jA-4wb7A:24.3 | 4u5jA-4wb7A:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wb7 | DNAJ HOMOLOGSUBFAMILY B MEMBER1,CAMP-DEPENDENTPROTEIN KINASECATALYTIC SUBUNITALPHA (Homo sapiens) |
PF00069(Pkinase)PF00226(DnaJ) | 8 | LEU A 104VAL A 112ALA A 125TYR A 177GLY A 181ASN A 226LEU A 228ASP A 239 | ATP A 501 ( 4.3A)ATP A 501 (-4.0A)ATP A 501 (-3.4A)NoneNone ZN A 502 ( 2.5A)ATP A 501 (-4.5A) ZN A 503 (-1.9A) | 0.69A | 4u5jA-4wb7A:24.3 | 4u5jA-4wb7A:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wbo | RHODOPSIN KINASE (Bos taurus) |
PF00069(Pkinase)PF00615(RGS) | 9 | LEU A 193GLY A 196VAL A 201ALA A 214MET A 267GLY A 270ASN A 319LEU A 321ASP A 332 | ANW A 601 ( 4.0A)NoneNoneANW A 601 (-3.4A)NoneANW A 601 ( 4.5A)NoneANW A 601 (-4.9A)None | 0.67A | 4u5jA-4wboA:25.2 | 4u5jA-4wboA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wsq | AP2-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 52GLY A 55VAL A 60ALA A 72GLY A 132ASN A 181LEU A 183ASP A 194 | KSA A 405 ( 4.0A)KSA A 405 ( 4.9A)KSA A 405 ( 4.9A)KSA A 405 (-3.2A)KSA A 405 (-3.5A)KSA A 405 (-4.0A)KSA A 405 (-4.6A) ZN A 403 ( 2.6A) | 0.71A | 4u5jA-4wsqA:25.5 | 4u5jA-4wsqA:26.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xey | TYROSINE-PROTEINKINASE ABL1 (Homo sapiens) |
no annotation | 8 | LEU B 267VAL B 275ALA B 288MET B 337GLY B 340ASN B 387LEU B 389ALA B 399 | 1N1 B 601 (-3.7A)1N1 B 601 ( 4.9A)1N1 B 601 (-3.5A)None1N1 B 601 (-3.5A)None1N1 B 601 (-4.3A)1N1 B 601 (-3.5A) | 0.53A | 4u5jA-4xeyB:34.3 | 4u5jA-4xeyB:36.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xi2 | TYROSINE-PROTEINKINASE BTK (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 8 | LEU A 408VAL A 416ALA A 428TYR A 476MET A 477GLY A 480ASN A 526LEU A 528 | None | 0.69A | 4u5jA-4xi2A:24.4 | 4u5jA-4xi2A:28.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4xuf | RECEPTOR-TYPETYROSINE-PROTEINKINASE FLT3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 616GLY A 619VAL A 624ALA A 642TYR A 693GLY A 697ASN A 816LEU A 818 | P30 A1001 (-4.0A)NoneP30 A1001 ( 4.8A)P30 A1001 (-3.5A)P30 A1001 ( 4.4A)P30 A1001 (-3.5A)NoneP30 A1001 (-4.3A) | 0.64A | 4u5jA-4xufA:30.7 | 4u5jA-4xufA:38.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 8 | LEU A 408VAL A 416ALA A 428TYR A 476MET A 477GLY A 480ASN A 526LEU A 528 | 746 A 702 (-3.8A)746 A 702 ( 4.3A)746 A 702 (-2.4A)746 A 702 (-4.4A)None746 A 702 (-3.6A)746 A 702 (-2.8A)746 A 702 (-4.4A) | 0.32A | 4u5jA-4y93A:32.2 | 4u5jA-4y93A:26.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 484VAL A 492ALA A 512TYR A 563GLY A 567ASN A 628LEU A 630ALA A 640 | 38O A1769 (-3.2A)38O A1769 (-4.5A)38O A1769 (-3.6A)38O A1769 (-4.2A)38O A1769 (-3.4A)None38O A1769 (-4.6A)EDO A1766 ( 4.4A) | 0.49A | 4u5jA-5a46A:31.2 | 4u5jA-5a46A:32.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ci7 | SERINE/THREONINE-PROTEIN KINASE ULK1 (Homo sapiens) |
PF00069(Pkinase) | 8 | GLY A 25VAL A 30ALA A 44TYR A 94GLY A 98ASN A 143LEU A 145ALA A 164 | GOL A 404 ( 3.2A)51W A 401 ( 4.3A)51W A 401 (-3.4A)51W A 401 ( 3.4A)51W A 401 (-3.7A)GOL A 404 ( 4.6A)51W A 401 (-4.5A)None | 0.57A | 4u5jA-5ci7A:27.1 | 4u5jA-5ci7A:27.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5es1 | MAP/MICROTUBULEAFFINITY-REGULATINGKINASE 4 (Homo sapiens) |
PF00069(Pkinase)PF00627(UBA) | 9 | GLY A 65VAL A 70ALA A 83TYR A 134GLY A 138ASN A 183LEU A 185ALA A 195ASP A 196 | 5RC A4000 ( 3.9A)5RC A4000 (-4.6A)5RC A4000 (-3.6A)5RC A4000 (-4.5A)5RC A4000 (-3.3A)5RC A4000 (-4.1A)None5RC A4000 ( 3.9A)5RC A4000 (-3.6A) | 0.85A | 4u5jA-5es1A:25.0 | 4u5jA-5es1A:29.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fm2 | PROTO-ONCOGENETYROSINE-PROTEINKINASE RECEPTOR RET (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 730GLY A 733VAL A 738ALA A 756TYR A 806GLY A 810ASN A 879LEU A 881 | PP1 A2012 (-4.6A)NonePP1 A2012 (-4.4A)PP1 A2012 (-3.2A)NonePTR A 809 (-2.4A)NonePP1 A2012 (-4.6A) | 0.62A | 4u5jA-5fm2A:34.5 | 4u5jA-5fm2A:31.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hu3 | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE II ALPHACHAIN (Drosophilamelanogaster) |
PF00069(Pkinase) | 8 | LEU A 20VAL A 28ALA A 41GLY A 96ASN A 141LEU A 143ALA A 156ASP A 157 | ADP A 301 ( 4.0A)ADP A 301 (-3.7A)ADP A 301 (-3.5A)None MG A 302 ( 2.8A)ADP A 301 (-4.7A)ADP A 301 ( 4.8A) MG A 302 ( 3.3A) | 0.55A | 4u5jA-5hu3A:26.8 | 4u5jA-5hu3A:26.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 57GLY A 60VAL A 65ALA A 77TYR A 132GLY A 136LEU A 187ASP A 198 | IDV A 401 (-3.8A)IDV A 401 (-3.5A)IDV A 401 (-4.6A)IDV A 401 (-3.6A)IDV A 401 (-3.5A)IDV A 401 (-3.4A)IDV A 401 (-4.4A)IDV A 401 (-4.0A) | 0.75A | 4u5jA-5i3oA:24.9 | 4u5jA-5i3oA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i3o | BMP-2-INDUCIBLEPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 8 | LEU A 57VAL A 65ALA A 77TYR A 132GLY A 136ASN A 185LEU A 187ASP A 198 | IDV A 401 (-3.8A)IDV A 401 (-4.6A)IDV A 401 (-3.6A)IDV A 401 (-3.5A)IDV A 401 (-3.4A)IDV A 401 (-4.1A)IDV A 401 (-4.4A)IDV A 401 (-4.0A) | 0.76A | 4u5jA-5i3oA:24.9 | 4u5jA-5i3oA:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5iso | 5'-AMP-ACTIVATEDPROTEIN KINASECATALYTIC SUBUNITALPHA-2 (Homo sapiens) |
PF00069(Pkinase)PF16579(AdenylateSensor) | 9 | LEU A 22VAL A 30ALA A 43TYR A 95GLY A 99ASN A 144LEU A 146ALA A 156ASP A 157 | STU A 601 (-4.1A)STU A 601 (-4.8A)STU A 601 (-3.3A)STU A 601 (-4.3A)STU A 601 ( 4.0A)STU A 601 (-4.3A)STU A 601 (-4.5A)STU A 601 (-3.5A)STU A 601 (-3.5A) | 0.95A | 4u5jA-5isoA:25.1 | 4u5jA-5isoA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kbr | SERINE/THREONINE-PROTEIN KINASE PAK 1 (Homo sapiens) |
PF00069(Pkinase) | 8 | GLY A 279VAL A 284ALA A 297TYR A 346GLY A 350ASN A 394LEU A 396ASP A 407 | NoneIPW A 601 (-4.2A)IPW A 601 (-3.5A)IPW A 601 (-4.5A)IPW A 601 ( 3.8A)NoneIPW A 601 (-4.5A)None | 0.53A | 4u5jA-5kbrA:24.6 | 4u5jA-5kbrA:26.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5td2 | TYROSINE-PROTEINKINASE MER (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 593VAL A 601ALA A 617MET A 674GLY A 677ASN A 728ALA A 740ASP A 741 | 7AE A1000 ( 3.9A)7AE A1000 ( 4.9A)7AE A1000 (-3.3A)None7AE A1000 ( 3.7A)7AE A1000 (-4.7A)7AE A1000 ( 3.7A)7AE A1000 (-4.4A) | 0.54A | 4u5jA-5td2A:21.7 | 4u5jA-5td2A:38.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tvt | MATERNAL EMBRYONICLEUCINE ZIPPERKINASE (Homo sapiens) |
no annotation | 8 | GLY A 20VAL A 25ALA A 38TYR A 88GLY A 92ASN A 137LEU A 139ASP A 150 | 7LV A 401 ( 3.9A)7LV A 401 ( 4.6A)7LV A 401 (-3.4A)7LV A 401 (-4.6A)NoneNone7LV A 401 (-4.9A)7LV A 401 (-4.2A) | 0.73A | 4u5jA-5tvtA:19.4 | 4u5jA-5tvtA:26.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u6b | TYROSINE-PROTEINKINASE RECEPTOR UFO (Homo sapiens) |
PF07714(Pkinase_Tyr) | 8 | LEU A 542VAL A 550ALA A 565MET A 623GLY A 626ASN A 677ALA A 689ASP A 690 | 7YS A9001 (-4.1A)7YS A9001 (-4.2A)7YS A9001 (-3.3A)7YS A9001 (-4.7A)7YS A9001 (-3.4A)None7YS A9001 (-3.4A)None | 0.67A | 4u5jA-5u6bA:30.9 | 4u5jA-5u6bA:37.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7q | RHO-ASSOCIATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 10 | GLY A 101VAL A 106ALA A 119TYR A 171MET A 172GLY A 175ASN A 219LEU A 221ALA A 231ASP A 232 | None | 0.52A | 4u5jA-5u7qA:22.0 | 4u5jA-5u7qA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uuu | BETA-ADRENERGICRECEPTOR KINASE 1 (Homo sapiens) |
PF00069(Pkinase)PF00615(RGS) | 8 | GLY A 200VAL A 205ALA A 218MET A 274GLY A 277ASN A 322LEU A 324ASP A 335 | QRW A 601 (-3.6A)QRW A 601 (-4.7A)QRW A 601 (-3.4A)MES A 604 (-3.9A)NoneNoneNoneQRW A 601 (-3.7A) | 0.68A | 4u5jA-5uuuA:24.9 | 4u5jA-5uuuA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w5j | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) |
no annotation | 9 | LEU A 24VAL A 32ALA A 45TYR A 97MET A 98GLY A 101ASN A 151LEU A 153ALA A 163 | 9WS A 401 ( 4.2A)9WS A 401 ( 4.6A)9WS A 401 (-3.3A)NoneNone9WS A 401 ( 4.3A)None9WS A 401 (-4.6A)9WS A 401 ( 4.0A) | 0.57A | 4u5jA-5w5jA:24.2 | 4u5jA-5w5jA:28.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wnm | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 4 (Mus musculus) |
no annotation | 8 | VAL A 36ALA A 49TYR A 98MET A 99GLY A 102ASN A 148LEU A 150ASP A 161 | VX6 A 402 (-4.6A)VX6 A 402 (-3.2A)VX6 A 402 (-4.3A)NoneVX6 A 402 (-3.5A)NoneVX6 A 402 (-4.4A)VX6 A 402 (-4.3A) | 0.47A | 4u5jA-5wnmA:28.9 | 4u5jA-5wnmA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao5 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
no annotation | 9 | LEU A 33GLY A 36VAL A 41ALA A 54TYR A 101GLY A 105ASN A 151LEU A 153ALA A 163 | ANP A 501 ( 3.8A)NoneANP A 501 (-4.4A)ANP A 501 ( 3.7A)ANP A 501 ( 4.2A)ANP A 501 ( 4.0A)ANP A 501 ( 2.6A)ANP A 501 (-4.6A)None | 1.07A | 4u5jA-6ao5A:23.6 | 4u5jA-6ao5A:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ccf | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 1 (Homo sapiens) |
no annotation | 8 | GLY A 137VAL A 142ALA A 155GLY A 236ASN A 280LEU A 282ALA A 292ASP A 293 | NoneH1N A 501 (-4.4A)H1N A 501 (-3.4A)H1N A 501 (-3.6A)H1N A 501 (-4.5A)H1N A 501 (-4.8A)H1N A 501 ( 3.9A)H1N A 501 (-3.5A) | 0.51A | 4u5jA-6ccfA:24.8 | 4u5jA-6ccfA:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3d | INTERLEUKIN-1RECEPTOR-ASSOCIATEDKINASE 4 (Homo sapiens) |
no annotation | 9 | GLY A 195VAL A 200ALA A 211TYR A 264MET A 265GLY A 268ASN A 316LEU A 318ASP A 329 | NoneCJT A 502 ( 4.8A)CJT A 502 (-3.4A)CJT A 502 (-4.5A)CJT A 502 (-4.9A)CJT A 502 ( 4.3A)NoneCJT A 502 (-4.7A)CJT A 502 ( 4.0A) | 0.48A | 4u5jA-6f3dA:26.1 | 4u5jA-6f3dA:13.57 |