SIMILAR PATTERNS OF AMINO ACIDS FOR 4U15_B_0HKB1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mac 1,3-1,4-BETA-D-GLUCA
N 4-GLUCANOHYDROLASE

(Paenibacillus
macerans) 		PF00722
(Glyco_hydro_16) 		4 ASN A 180
TRP A 182
LEU A 191
PHE A 108
 None
 1.36A 4u15B-1macA:
undetectable		 4u15B-1macA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 ASN A 738
TRP A 736
LEU A 666
PHE A 724
 None
 1.20A 4u15B-1nphA:
undetectable		 4u15B-1nphA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ray PR DOMAIN-CONTAINING
PROTEIN 11

(Homo sapiens) 		PF00856
(SET) 		4 ASN A 138
TRP A 139
LEU A 177
PHE A 115
 None
 1.36A 4u15B-3rayA:
undetectable		 4u15B-3rayA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Enterobacter
sp. 638) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 324
TRP A 306
LEU A 293
PHE A 276
 None
 1.45A 4u15B-3tjiA:
0.0		 4u15B-3tjiA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASN A 324
TRP A 306
LEU A 293
PHE A 276
 None
 1.40A 4u15B-4gisA:
0.0		 4u15B-4gisA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASN A 152
TRP A 199
LEU A 225
PHE A 239
 0HK  A2000 ( 4.7A)
0HK  A2000 (-4.5A)
0HK  A2000 (-4.5A)
None
 0.30A 4u15B-4u14A:
40.9		 4u15B-4u14A:
89.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASN A 152
TRP A 199
LEU A 225
PHE A 239
 None
3C0  A1202 (-4.4A)
None
None
 0.53A 4u15B-4u16A:
47.3		 4u15B-4u16A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ASN A 117
TRP A 164
LEU A 190
PHE A 204
 OLC  A1208 ( 3.6A)
OLC  A1208 ( 4.0A)
P6G  A1205 (-4.6A)
None
 0.29A 4u15B-5dsgA:
44.9		 4u15B-5dsgA:
75.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		4 ASN A 150
TRP A 153
LEU A 162
PHE A  96
 None
 1.50A 4u15B-5gvvA:
0.0		 4u15B-5gvvA:
21.21