SIMILAR PATTERNS OF AMINO ACIDS FOR 4U15_A_0HKA2001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		3 ASN A  84
PHE A  82
TYR A  74
 None
 0.81A 4u15A-1ahaA:
undetectable		 4u15A-1ahaA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b7g PROTEIN
(GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE)

(Sulfolobus
solfataricus) 		PF01113
(DapB_N)
PF02800
(Gp_dh_C) 		3 ASN O  87
PHE O 106
TYR O  93
 None
 0.73A 4u15A-1b7gO:
undetectable		 4u15A-1b7gO:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica) 		PF00161
(RIP) 		3 ASN Y  84
PHE Y  82
TYR Y  74
 None
 0.77A 4u15A-1bryY:
0.0		 4u15A-1bryY:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7o CYSTALYSIN

(Treponema
denticola) 		PF00155
(Aminotran_1_2) 		3 ASN A 132
PHE A 127
TYR A 123
 None
None
PPG  A1500 (-3.6A)
 0.87A 4u15A-1c7oA:
0.0		 4u15A-1c7oA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 ASN A 182
PHE A 444
TYR A  90
 None
 0.67A 4u15A-1cbgA:
0.0		 4u15A-1cbgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		3 ASN A 177
PHE A 428
TYR A  88
 None
 0.60A 4u15A-1gnxA:
undetectable		 4u15A-1gnxA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		3 ASN A 185
PHE A 450
TYR A  90
 None
 0.69A 4u15A-1hxjA:
0.0		 4u15A-1hxjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		3 ASN A  76
PHE A  69
TYR A  54
 None
 0.74A 4u15A-1k4jA:
undetectable		 4u15A-1k4jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k68 PHYTOCHROME RESPONSE
REGULATOR RCPA

(Tolypothrix sp.
PCC 7601) 		PF00072
(Response_reg) 		3 ASN A 104
PHE A 109
TYR A 112
 None
 0.77A 4u15A-1k68A:
undetectable		 4u15A-1k68A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwi PROTEGRIN-3
PRECURSOR

(Sus scrofa) 		PF00666
(Cathelicidins) 		3 ASN A 101
PHE A  98
TYR A  55
 None
 0.78A 4u15A-1kwiA:
undetectable		 4u15A-1kwiA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9x GAMMA-GLUTAMYL
HYDROLASE

(Homo sapiens) 		PF07722
(Peptidase_C26) 		3 ASN A 183
PHE A 189
TYR A 210
 None
 0.90A 4u15A-1l9xA:
undetectable		 4u15A-1l9xA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		3 ASN A 256
PHE A 254
TYR A 161
 None
 0.76A 4u15A-1mpoA:
undetectable		 4u15A-1mpoA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oqv TOXIN-COREGULATED
PILUS SUBUNIT

(Vibrio cholerae) 		PF05946
(TcpA) 		3 ASN A 105
PHE A 108
TYR A 133
 None
 0.89A 4u15A-1oqvA:
undetectable		 4u15A-1oqvA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk6 COMPLEMENT C1Q
SUBCOMPONENT, B
CHAIN PRECURSOR

(Homo sapiens) 		PF00386
(C1q) 		3 ASN B 124
PHE B  97
TYR B 141
 None
 0.88A 4u15A-1pk6B:
undetectable		 4u15A-1pk6B:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		3 ASN A 299
PHE A 231
TYR A 190
 None
 0.75A 4u15A-1q1lA:
undetectable		 4u15A-1q1lA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcs TRICHOSANTHIN

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		3 ASN A  84
PHE A  82
TYR A  74
 None
 0.89A 4u15A-1tcsA:
undetectable		 4u15A-1tcsA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		3 ASN A 188
PHE A 451
TYR A  96
 None
 0.71A 4u15A-1v02A:
undetectable		 4u15A-1v02A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vff BETA-GLUCOSIDASE

(Pyrococcus
horikoshii) 		PF00232
(Glyco_hydro_1) 		3 ASN A 154
PHE A 360
TYR A  67
 None
 0.70A 4u15A-1vffA:
undetectable		 4u15A-1vffA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x67 DREBRIN-LIKE PROTEIN

(Homo sapiens) 		PF00241
(Cofilin_ADF) 		3 ASN A  11
PHE A 114
TYR A  71
 None
 0.88A 4u15A-1x67A:
undetectable		 4u15A-1x67A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		3 ASN A 941
PHE A 981
TYR A 895
 None
 0.80A 4u15A-1xc6A:
undetectable		 4u15A-1xc6A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ynt PROTEIN L

(Finegoldia
magna) 		PF02246
(B1) 		3 ASN E 873
PHE E 839
TYR E 851
 None
 0.86A 4u15A-1yntE:
undetectable		 4u15A-1yntE:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b92 INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		3 ASN A 111
PHE A 116
TYR A 144
 ASN  A 111 ( 0.6A)
PHE  A 116 ( 1.3A)
TYR  A 144 ( 1.3A)
 0.58A 4u15A-2b92A:
undetectable		 4u15A-2b92A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7s RNA-DEPENDENT RNA
POLYMERASE

(Foot-and-mouth
disease virus) 		PF00680
(RdRP_1) 		3 ASN A 247
PHE A 357
TYR A 317
 None
 0.87A 4u15A-2d7sA:
undetectable		 4u15A-2d7sA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		3 ASN A 302
PHE A 307
TYR A 286
 None
 0.77A 4u15A-2dkdA:
undetectable		 4u15A-2dkdA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		3 ASN A 169
PHE A 413
TYR A  76
 None
 0.68A 4u15A-2e3zA:
undetectable		 4u15A-2e3zA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g8l 287AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01937
(DUF89) 		3 ASN A 190
PHE A 112
TYR A 162
 None
 0.74A 4u15A-2g8lA:
undetectable		 4u15A-2g8lA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grm PRGX

(Enterococcus
faecalis) 		PF01381
(HTH_3) 		3 ASN A  88
PHE A  86
TYR A 116
 None
 0.84A 4u15A-2grmA:
undetectable		 4u15A-2grmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3f GLYCOLIPID
TRANSFER-LIKE
PROTEIN

(Galdieria
sulphuraria) 		PF08718
(GLTP) 		3 ASN A  58
PHE A  53
TYR A 129
 None
 0.78A 4u15A-2i3fA:
2.7		 4u15A-2i3fA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuj LIPOXYGENASE L-5

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASN A  21
PHE A 121
TYR A 146
 None
 0.85A 4u15A-2iujA:
undetectable		 4u15A-2iujA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		3 ASN A  21
PHE A 133
TYR A 158
 None
 0.83A 4u15A-2iukA:
undetectable		 4u15A-2iukA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		3 ASN A 165
PHE A 396
TYR A  76
 IDE  A1446 (-3.1A)
None
None
 0.66A 4u15A-2j7cA:
undetectable		 4u15A-2j7cA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf7 STRICTOSIDINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 ASN A 206
PHE A 463
TYR A 114
 None
 0.69A 4u15A-2jf7A:
undetectable		 4u15A-2jf7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noq 60S RIBOSOMAL
PROTEIN L11-B

(Saccharomyces
cerevisiae) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		3 ASN H  94
PHE H 126
TYR H 127
 None
 0.87A 4u15A-2noqH:
undetectable		 4u15A-2noqH:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9r BETA-GLUCOSIDASE B

(Paenibacillus
polymyxa) 		PF00232
(Glyco_hydro_1) 		3 ASN A 166
PHE A 400
TYR A  78
 None
 0.65A 4u15A-2o9rA:
undetectable		 4u15A-2o9rA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ol5 PAI 2 PROTEIN

(Geobacillus
stearothermophilus) 		PF04299
(FMN_bind_2) 		3 ASN A 110
PHE A 153
TYR A  52
 None
 0.61A 4u15A-2ol5A:
undetectable		 4u15A-2ol5A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2v ALPHA-2,3-SIALYLTRAN
SFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		3 ASN A  32
PHE A 245
TYR A  55
 None
 0.83A 4u15A-2p2vA:
0.2		 4u15A-2p2vA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN

(Nostoc
punctiforme) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		3 ASN A 274
PHE A 302
TYR A 305
 None
 0.86A 4u15A-2r3sA:
undetectable		 4u15A-2r3sA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkc HEMAGGLUTININ

(Measles
morbillivirus) 		PF00423
(HN) 		3 ASN A 274
PHE A 255
TYR A 232
 None
 0.83A 4u15A-2rkcA:
undetectable		 4u15A-2rkcA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		3 ASN A 421
PHE A 353
TYR A 365
 None
 0.88A 4u15A-2v5iA:
undetectable		 4u15A-2v5iA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8l GLUCOAMYLASE A

(Rhizopus oryzae) 		PF03370
(CBM_21) 		3 ASN A  52
PHE A  82
TYR A  16
 None
 0.86A 4u15A-2v8lA:
undetectable		 4u15A-2v8lA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbk TAILSPIKE-PROTEIN

(Shigella virus
Sf6) 		PF12708
(Pectate_lyase_3) 		3 ASN A 410
PHE A 437
TYR A 436
 None
 0.87A 4u15A-2vbkA:
undetectable		 4u15A-2vbkA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vmf BETA-MANNOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2) 		3 ASN A  77
PHE A 570
TYR A 661
 CL  A1897 (-3.5A)
None
None
 0.81A 4u15A-2vmfA:
undetectable		 4u15A-2vmfA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 ASN A 197
PHE A 363
TYR A 239
 None
 0.89A 4u15A-2x5fA:
undetectable		 4u15A-2x5fA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8p CHOLINE-BINDING
PROTEIN F

(Streptococcus
pneumoniae) 		PF01473
(CW_binding_1) 		3 ASN A 122
PHE A 120
TYR A  76
 None
 0.64A 4u15A-2x8pA:
undetectable		 4u15A-2x8pA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ASN A  91
PHE A 188
TYR A 186
 None
 0.84A 4u15A-2ya2A:
undetectable		 4u15A-2ya2A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3) 		3 ASN A  58
PHE A  66
TYR A  81
 None
 0.83A 4u15A-2zsiA:
undetectable		 4u15A-2zsiA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		3 ASN A 164
PHE A 415
TYR A  72
 TRS  A 500 ( 4.8A)
None
None
 0.64A 4u15A-3ahyA:
undetectable		 4u15A-3ahyA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiv BETA-GLUCOSIDASE

(Secale cereale) 		PF00232
(Glyco_hydro_1) 		3 ASN A 190
PHE A 453
TYR A 100
 None
 0.69A 4u15A-3aivA:
undetectable		 4u15A-3aivA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 ASN A 846
PHE A 830
TYR A 862
 None
 0.85A 4u15A-3ak5A:
undetectable		 4u15A-3ak5A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3alx HEMAGGLUTININ,LINKER
,CDW150

(Measles
morbillivirus;
Saguinus
oedipus;
synthetic
construct) 		PF00423
(HN)
PF06214
(SLAM) 		3 ASN A 274
PHE A 255
TYR A 232
 None
 0.83A 4u15A-3alxA:
undetectable		 4u15A-3alxA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8a HEXOKINASE-1

(Saccharomyces
cerevisiae) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ASN X 210
PHE X 240
TYR X 241
 BGC  X 501 (-3.2A)
None
None
 0.89A 4u15A-3b8aX:
undetectable		 4u15A-3b8aX:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfz UPF0100 PROTEIN
MJ1186

(Methanocaldococcus
jannaschii) 		PF13531
(SBP_bac_11) 		3 ASN A 320
PHE A  52
TYR A 289
 None
 0.89A 4u15A-3cfzA:
undetectable		 4u15A-3cfzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cg1 UPF0100 PROTEIN
PF0080

(Pyrococcus
furiosus) 		PF13531
(SBP_bac_11) 		3 ASN A 319
PHE A  47
TYR A 286
 None
 0.75A 4u15A-3cg1A:
undetectable		 4u15A-3cg1A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eja PROTEIN GH61E

(Thielavia
terrestris) 		PF03443
(Glyco_hydro_61) 		3 ASN A 171
PHE A  96
TYR A  75
 None
 0.89A 4u15A-3ejaA:
undetectable		 4u15A-3ejaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eka HYALURONIDASE, PHAGE
ASSOCIATED

(Streptococcus
pyogenes) 		PF07212
(Hyaluronidase_1) 		3 ASN A 280
PHE A 286
TYR A 295
 None
 0.85A 4u15A-3ekaA:
undetectable		 4u15A-3ekaA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fza GLUTAREDOXIN

(Populus tremula
x Populus
tremuloides) 		PF00462
(Glutaredoxin) 		3 ASN A  43
PHE A  39
TYR A  94
 None
 0.80A 4u15A-3fzaA:
undetectable		 4u15A-3fzaA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnr OS03G0212800 PROTEIN

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ASN A 177
PHE A 442
TYR A  87
 ASN  A 177 (-0.6A)
PHE  A 442 ( 1.3A)
TYR  A  87 ( 1.3A)
 0.68A 4u15A-3gnrA:
undetectable		 4u15A-3gnrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isy INTRACELLULAR
PROTEINASE INHIBITOR

(Bacillus
subtilis) 		PF12690
(BsuPI) 		3 ASN A  70
PHE A  35
TYR A  79
 None
 0.58A 4u15A-3isyA:
undetectable		 4u15A-3isyA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		3 ASN A 377
PHE A 372
TYR A 556
 None
 0.84A 4u15A-3kk7A:
undetectable		 4u15A-3kk7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lku UPF0363 PROTEIN
YOR164C

(Saccharomyces
cerevisiae) 		PF04190
(DUF410) 		3 ASN A 120
PHE A 126
TYR A  83
 None
 0.78A 4u15A-3lkuA:
2.5		 4u15A-3lkuA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muq UNCHARACTERIZED
CONSERVED PROTEIN

(Vibrio
parahaemolyticus) 		PF12849
(PBP_like_2) 		3 ASN A 135
PHE A 130
TYR A 189
 None
 0.76A 4u15A-3muqA:
undetectable		 4u15A-3muqA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppu GLUTATHIONE-S-TRANSF
ERASE

(Phanerochaete
chrysosporium) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ASN A 186
PHE A 181
TYR A  78
 None
 0.88A 4u15A-3ppuA:
undetectable		 4u15A-3ppuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ptk BETA-GLUCOSIDASE
OS4BGLU12

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ASN A 178
PHE A 440
TYR A  86
 TRS  A1164 ( 4.6A)
None
None
 0.69A 4u15A-3ptkA:
undetectable		 4u15A-3ptkA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 ASN A  87
PHE A 171
TYR A 209
 None
 0.85A 4u15A-3qt4A:
undetectable		 4u15A-3qt4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwn HYPOTHETICAL
NIGD-LIKE PROTEIN

(Bacteroides
caccae) 		PF12667
(NigD_N)
PF17415
(NigD_C) 		3 ASN A  53
PHE A  35
TYR A 132
 None
 0.88A 4u15A-3qwnA:
undetectable		 4u15A-3qwnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 3 ASN N 101
PHE N 105
TYR N  92
 None
None
LFA  N 487 (-4.6A)
 0.89A 4u15A-3rkoN:
2.9		 4u15A-3rkoN:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		3 ASN A 185
PHE A 467
TYR A  93
 None
 0.68A 4u15A-3u5uA:
undetectable		 4u15A-3u5uA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASN A 108
PHE A 195
TYR A 403
 QNB  A1162 (-4.9A)
QNB  A1162 (-4.4A)
QNB  A1162 (-3.9A)
 0.53A 4u15A-3uonA:
39.0		 4u15A-3uonA:
65.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		3 ASN A 227
PHE A 156
TYR A 196
 None
 0.78A 4u15A-3uowA:
undetectable		 4u15A-3uowA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		3 ASN A 227
PHE A 110
TYR A  81
 None
 0.87A 4u15A-3vs8A:
undetectable		 4u15A-3vs8A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		3 ASN A 181
PHE A 100
TYR A 118
 None
 0.82A 4u15A-3vseA:
undetectable		 4u15A-3vseA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		3 ASN A 169
PHE A 422
TYR A  81
 None
 0.62A 4u15A-3w53A:
undetectable		 4u15A-3w53A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		3 ASN A 165
PHE A 397
TYR A  76
 FCB  A 501 (-2.9A)
None
None
 0.68A 4u15A-3wh7A:
undetectable		 4u15A-3wh7A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj9 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2A

(Schizosaccharomyces
pombe) 		PF08662
(eIF2A) 		3 ASN A 277
PHE A 297
TYR A 245
 None
 0.86A 4u15A-3wj9A:
undetectable		 4u15A-3wj9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmy EXTRACELLULAR
EXO-ALPHA-L-ARABINOF
URANOSIDASE

(Streptomyces
coelicolor) 		PF03664
(Glyco_hydro_62) 		3 ASN A 343
PHE A 275
TYR A 268
 None
 0.74A 4u15A-3wmyA:
undetectable		 4u15A-3wmyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zef PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		3 ASN B1529
PHE B1525
TYR B1345
 None
 0.76A 4u15A-3zefB:
0.6		 4u15A-3zefB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		3 ASN A 163
PHE A 383
TYR A  74
 GOL  A 902 (-2.9A)
None
None
 0.67A 4u15A-3zjkA:
undetectable		 4u15A-3zjkA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4

(Mus musculus) 		PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 ASN A 803
PHE A 798
TYR A 765
 None
 0.88A 4u15A-4f7zA:
2.2		 4u15A-4f7zA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		3 ASN A  86
PHE A  77
TYR A  63
 None
 0.81A 4u15A-4fs3A:
undetectable		 4u15A-4fs3A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gri GLUTAMATE--TRNA
LIGASE

(Borreliella
burgdorferi) 		PF00749
(tRNA-synt_1c) 		3 ASN A 277
PHE A 302
TYR A  28
 None
 0.75A 4u15A-4griA:
undetectable		 4u15A-4griA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN

(Thermotoga
maritima;
Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		3 ASN A 172
PHE A 417
TYR A  83
 None
 0.67A 4u15A-4gxpA:
undetectable		 4u15A-4gxpA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ied CLASS D
BETA-LACTAMASE

(Fusobacterium
nucleatum) 		PF00905
(Transpeptidase) 		3 ASN A  75
PHE A  80
TYR A 111
 None
None
KCX  A  60 ( 3.8A)
 0.85A 4u15A-4iedA:
undetectable		 4u15A-4iedA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		3 ASN A 190
PHE A 187
TYR A 184
 None
 0.85A 4u15A-4lgvA:
undetectable		 4u15A-4lgvA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mee DIFFUSE ADHERENCE
ADHESIN

(Escherichia
coli) 		PF03797
(Autotransporter) 		3 ASN A1094
PHE A1099
TYR A1136
 None
 0.89A 4u15A-4meeA:
undetectable		 4u15A-4meeA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlo TCP PILUS VIRULENCE
REGULATORY PROTEIN

(Vibrio cholerae) 		PF00165
(HTH_AraC) 		3 ASN A 185
PHE A 245
TYR A 224
 CL  A 301 (-4.3A)
None
None
 0.89A 4u15A-4mloA:
undetectable		 4u15A-4mloA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnn GLUTAREDOXIN RELATED
PROTEIN

(Sulfolobus
solfataricus) 		PF13192
(Thioredoxin_3) 		3 ASN A  69
PHE A  74
TYR A  10
 None
 0.89A 4u15A-4mnnA:
undetectable		 4u15A-4mnnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q98 MAJOR FIMBRIAL
SUBUNIT PROTEIN

(Porphyromonas
gingivalis) 		PF06321
(P_gingi_FimA)
PF15495
(Fimbrillin_C) 		3 ASN A 351
PHE A 196
TYR A 256
 None
 0.84A 4u15A-4q98A:
undetectable		 4u15A-4q98A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi8 LYTIC POLYSACCHARIDE
MONOOXYGENASE

(Neurospora
crassa) 		PF03443
(Glyco_hydro_61) 		3 ASN A 176
PHE A 100
TYR A  79
 None
 0.85A 4u15A-4qi8A:
undetectable		 4u15A-4qi8A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlj BETA-GLUCOSIDASE 7

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ASN A 175
PHE A 431
TYR A  85
 CTT  A1001 (-3.1A)
None
None
 0.67A 4u15A-4qljA:
undetectable		 4u15A-4qljA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq2 C1Q-RELATED FACTOR

(Mus musculus) 		PF00386
(C1q) 		3 ASN A  36
PHE A  11
TYR A  53
 None
 0.86A 4u15A-4qq2A:
undetectable		 4u15A-4qq2A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		3 ASN A 104
PHE A  90
TYR A  40
 None
 0.78A 4u15A-4r84A:
undetectable		 4u15A-4r84A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 ASN A 178
PHE A 434
TYR A  88
 MVL  A 501 (-2.9A)
None
None
 0.67A 4u15A-4re2A:
undetectable		 4u15A-4re2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		3 ASN A 263
PHE A 179
TYR A 309
 None
None
NAG  A 501 (-4.6A)
 0.84A 4u15A-4rldA:
undetectable		 4u15A-4rldA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u14 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASN A 152
PHE A 239
TYR A 506
 0HK  A2000 ( 4.7A)
None
0HK  A2000 (-4.1A)
 0.14A 4u15A-4u14A:
40.4		 4u15A-4u14A:
89.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u16 MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASN A 152
PHE A 239
TYR A 506
 None
None
3C0  A1202 (-3.7A)
 0.40A 4u15A-4u16A:
50.6		 4u15A-4u16A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf7 GLYCOPROTEIN

(Ghanaian bat
henipavirus) 		PF00423
(HN) 		3 ASN A 544
PHE A 559
TYR A 603
 None
ACT  A1626 (-3.5A)
None
 0.88A 4u15A-4uf7A:
undetectable		 4u15A-4uf7A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uss GLUTATHIONYL
HYDROQUINONE
REDUCTASE

(Populus
trichocarpa) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ASN A 157
PHE A 152
TYR A  41
 None
 0.85A 4u15A-4ussA:
undetectable		 4u15A-4ussA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4win GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase) 		3 ASN A 227
PHE A 156
TYR A 196
 None
 0.72A 4u15A-4winA:
undetectable		 4u15A-4winA:
20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ASN A 117
PHE A 204
TYR A 416
 OLC  A1208 ( 3.6A)
None
0HK  A1201 (-4.2A)
 0.11A 4u15A-5dsgA:
43.6		 4u15A-5dsgA:
75.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		3 ASN A   7
PHE A 106
TYR A 214
 None
 0.90A 4u15A-5ewtA:
undetectable		 4u15A-5ewtA:
20.75