SIMILAR PATTERNS OF AMINO ACIDS FOR 4U0I_A_0LIA1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 428
LYS A 430
THR A 474
GLY A 480
HIS A 519
LEU A 528
 None
 0.64A 4u0iA-1k2pA:
27.5		 4u0iA-1k2pA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.45A 4u0iA-1k9aA:
31.3		 4u0iA-1k9aA:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 606
LYS A 608
GLY A 660
HIS A 722
LEU A 731
ASP A 742
 None
 0.60A 4u0iA-1lufA:
36.3		 4u0iA-1lufA:
36.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 288
LYS A 290
THR A 334
GLY A 340
HIS A 380
LEU A 389
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
 0.47A 4u0iA-1opkA:
30.5		 4u0iA-1opkA:
24.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 642
LYS A 644
CYH A 694
GLY A 697
HIS A 809
LEU A 818
CYH A 828
ASP A 829
 None
 0.64A 4u0iA-1rjbA:
39.8		 4u0iA-1rjbA:
55.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 ALA A 621
LYS A 623
LEU A 644
THR A 670
CYH A 673
GLY A 676
CYH A 788
HIS A 790
LEU A 799
CYH A 809
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
STI  A   3 ( 3.8A)
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-4.5A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.35A 4u0iA-1t46A:
35.8		 4u0iA-1t46A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  55
LYS A  57
LEU A  80
CYH A 108
GLY A 110
HIS A 149
LEU A 158
 None
 0.72A 4u0iA-1u5qA:
23.6		 4u0iA-1u5qA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
CYH A  87
GLY A  90
HIS A 128
LEU A 137
 HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
None
HYM  A 400 (-4.5A)
 0.49A 4u0iA-1zltA:
20.9		 4u0iA-1zltA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 111
LYS A 113
GLY A 165
HIS A 203
LEU A 212
CYH A 225
ASP A 226
 None
 0.93A 4u0iA-2ac5A:
19.2		 4u0iA-2ac5A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 111
LYS A 113
LEU A 133
GLY A 165
HIS A 203
LEU A 212
CYH A 225
 None
 0.86A 4u0iA-2ac5A:
19.2		 4u0iA-2ac5A:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA X  37
LYS X  39
THR X  82
GLY X  88
HIS X 128
LEU X 137
 STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
STU  X 902 (-4.4A)
 0.47A 4u0iA-2dq7X:
31.3		 4u0iA-2dq7X:
35.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A  40
LYS A  42
LEU A  63
HIS A 135
LEU A 144
CYH A 154
 ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.8A)
 0.64A 4u0iA-2f9gA:
21.6		 4u0iA-2f9gA:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
LYS A 273
THR A 316
GLY A 322
HIS A 362
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.60A 4u0iA-2hk5A:
31.3		 4u0iA-2hk5A:
38.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
LYS A 273
THR A 316
GLY A 322
LEU A 371
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.66A 4u0iA-2hk5A:
31.3		 4u0iA-2hk5A:
38.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  76
LYS A  78
LEU A  98
GLY A 130
HIS A 168
LEU A 177
CYH A 190
 None
 0.76A 4u0iA-2hw6A:
20.8		 4u0iA-2hw6A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LYS A  78
LEU A  98
GLY A 130
HIS A 168
LEU A 177
CYH A 190
PHE A 192
 None
 1.41A 4u0iA-2hw6A:
20.8		 4u0iA-2hw6A:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
THR A 315
GLY A 321
HIS A 361
LEU A 370
ASP A 381
PHE A 382
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-4.9A)
GIN  A 600 (-4.0A)
 0.76A 4u0iA-2hz0A:
32.1		 4u0iA-2hz0A:
35.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
CYH A 502
GLY A 505
HIS A 544
LEU A 553
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
4ST  A1687 (-3.2A)
None
4ST  A1687 (-4.4A)
4ST  A1687 (-4.7A)
 0.74A 4u0iA-2j0jA:
33.1		 4u0iA-2j0jA:
21.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
CYH A 502
GLY A 505
HIS A 544
LEU A 553
ASP A 564
 BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
BII  A1687 (-3.6A)
None
BII  A1687 (-4.2A)
None
 0.76A 4u0iA-2jkmA:
31.9		 4u0iA-2jkmA:
33.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
LYS A 273
THR A 316
GLY A 322
HIS A 362
LEU A 371
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.64A 4u0iA-2og8A:
31.4		 4u0iA-2og8A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 614
LYS A 616
THR A 663
CYH A 666
GLY A 669
CYH A 774
HIS A 776
LEU A 785
ASP A 796
 None
 0.74A 4u0iA-2ogvA:
39.8		 4u0iA-2ogvA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LEU A 876
GLY A 908
HIS A 962
LEU A 971
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 ( 4.5A)
MR9  A 301 ( 3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.80A 4u0iA-2p4iA:
23.8		 4u0iA-2p4iA:
39.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		7 ALA A  46
LYS A  48
LEU A  77
GLY A 109
HIS A 147
LEU A 156
ASP A 167
 ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.91A 4u0iA-2phkA:
22.6		 4u0iA-2phkA:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LYS A 217
THR A 265
GLY A 271
HIS A 319
LEU A 328
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.47A 4u0iA-2qluA:
25.1		 4u0iA-2qluA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 445
LEU A 463
GLY A 495
HIS A 533
LEU A 542
CYH A 556
ASP A 557
 None
 1.36A 4u0iA-2wntA:
18.7		 4u0iA-2wntA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 445
LEU A 463
THR A 489
GLY A 495
HIS A 533
CYH A 556
ASP A 557
 None
 1.22A 4u0iA-2wntA:
18.7		 4u0iA-2wntA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 445
LYS A 447
LEU A 463
GLY A 495
HIS A 533
LEU A 542
CYH A 556
 None
 1.18A 4u0iA-2wntA:
18.7		 4u0iA-2wntA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 445
LYS A 447
LEU A 463
THR A 489
GLY A 495
HIS A 533
CYH A 556
 None
 1.00A 4u0iA-2wntA:
18.7		 4u0iA-2wntA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
LYS A 653
THR A 699
GLY A 705
HIS A 744
LEU A 753
ASP A 764
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
None
Q9G  A1898 (-4.3A)
None
 0.87A 4u0iA-2xyuA:
32.6		 4u0iA-2xyuA:
33.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
GLY A 567
CYH A 619
HIS A 621
LEU A 630
PHE A 489
 C4F  A   1 (-3.3A)
None
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.7A)
 0.67A 4u0iA-3c4fA:
33.0		 4u0iA-3c4fA:
48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
LYS A 222
THR A 266
GLY A 272
HIS A 312
LEU A 321
 None
 0.44A 4u0iA-3d7uA:
26.3		 4u0iA-3d7uA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 663
GLY A 717
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 3.9A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.47A 4u0iA-3dkoA:
32.7		 4u0iA-3dkoA:
34.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  51
LYS A  53
LEU A  75
THR A 106
HIS A 148
ASP A 168
PHE A 169
 NIL  A   1 (-3.7A)
None
NIL  A   1 ( 4.8A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.3A)
NIL  A   1 (-4.6A)
NIL  A   1 (-3.5A)
 1.02A 4u0iA-3gp0A:
22.2		 4u0iA-3gp0A:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 ALA A 859
LYS A 861
LEU A 882
CYH A 912
GLY A 915
CYH A1018
HIS A1020
LEU A1029
CYH A1039
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
8ST  A2001 (-3.8A)
None
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
8ST  A2001 (-4.2A)
None
8ST  A2001 ( 3.7A)
 0.57A 4u0iA-3hngA:
41.4		 4u0iA-3hngA:
48.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
LYS A 667
THR A 713
GLY A 719
HIS A 758
LEU A 767
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.32A 4u0iA-3kulA:
32.6		 4u0iA-3kulA:
31.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 ALA A 700
LYS A 702
LEU A 719
CYH A 748
HIS A 795
LEU A 804
ASP A 828
 ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
ADP  A2101 (-4.2A)
None
ADP  A2101 (-4.4A)
SR  A2103 (-2.6A)
 1.01A 4u0iA-3lj0A:
22.0		 4u0iA-3lj0A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ALA A 579
LYS A 581
LEU A 600
GLY A 634
HIS A 675
LEU A 684
ASP A 720
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
None
None
None
ANP  A 877 (-2.9A)
 1.12A 4u0iA-3lltA:
21.4		 4u0iA-3lltA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
LYS A 231
THR A 279
GLY A 285
HIS A 330
LEU A 339
 LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
None
LDN  A   1 (-4.5A)
 0.51A 4u0iA-3mdyA:
25.2		 4u0iA-3mdyA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  46
LYS A  48
LEU A  70
CYH A 106
HIS A 147
LEU A 156
 None
 0.47A 4u0iA-3mi9A:
21.9		 4u0iA-3mi9A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 227
LYS A 229
THR A 277
GLY A 283
HIS A 328
LEU A 337
ASP A 348
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
None
LDN  A 600 (-4.6A)
None
 0.85A 4u0iA-3my0A:
24.8		 4u0iA-3my0A:
27.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
LYS A 578
GLY A 631
HIS A 674
LEU A 683
CYH A 693
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-3.2A)
None
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.67A 4u0iA-3ppzA:
28.1		 4u0iA-3ppzA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 ALA A 576
LYS A 578
THR A 625
GLY A 631
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
None
STU  A   1 (-4.3A)
 0.38A 4u0iA-3ppzA:
28.1		 4u0iA-3ppzA:
33.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
LYS A 219
THR A 267
GLY A 273
HIS A 320
LEU A 329
 TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
 0.60A 4u0iA-3q4tA:
24.1		 4u0iA-3q4tA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  84
LYS A  86
LEU A 119
THR A 144
GLY A 150
HIS A 188
LEU A 197
 ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
None
ANP  A1634 (-4.4A)
 0.82A 4u0iA-3q5iA:
20.0		 4u0iA-3q5iA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LYS A  86
LEU A 119
THR A 144
GLY A 150
HIS A 188
LEU A 197
ASP A 211
 ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
None
ANP  A1634 (-4.4A)
MG  A 529 (-2.2A)
 1.16A 4u0iA-3q5iA:
20.0		 4u0iA-3q5iA:
20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
LEU A 592
GLY A 623
HIS A 677
LEU A 686
ASP A 697
 0F4  A 902 (-3.2A)
0F4  A 902 (-4.7A)
0F4  A 902 (-3.4A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
 0.62A 4u0iA-3v5qA:
28.7		 4u0iA-3v5qA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 866
LEU A 889
CYH A 919
GLY A 922
CYH A1024
LEU A1035
CYH A1045
ASP A1046
 4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
None
None
 0.70A 4u0iA-3vidA:
36.1		 4u0iA-3vidA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 866
LEU A 889
CYH A 919
GLY A 922
HIS A1026
LEU A1035
CYH A1045
ASP A1046
 4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.3A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
None
None
 0.63A 4u0iA-3vidA:
36.1		 4u0iA-3vidA:
47.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 866
LEU A 889
CYH A 919
GLY A 922
CYH A1024
HIS A1026
LEU A1035
CYH A1045
 LEV  A1201 (-3.5A)
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.53A 4u0iA-3wzdA:
35.3		 4u0iA-3wzdA:
53.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
LYS A 868
LEU A 889
CYH A 919
GLY A 922
LEU A1035
CYH A1045
 LEV  A1201 (-3.5A)
None
LEV  A1201 ( 4.4A)
LEV  A1201 (-4.1A)
LEV  A1201 (-3.6A)
LEV  A1201 (-4.8A)
GOL  A1210 ( 3.3A)
 0.66A 4u0iA-3wzdA:
35.3		 4u0iA-3wzdA:
53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  31
LYS A  33
LEU A  54
HIS A 123
LEU A 132
CYH A 142
 38R  A 350 (-3.4A)
38R  A 350 (-2.9A)
None
None
38R  A 350 (-4.3A)
38R  A 350 ( 3.9A)
 0.49A 4u0iA-3zduA:
22.4		 4u0iA-3zduA:
24.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 649
LYS A 651
THR A 697
GLY A 703
HIS A 742
LEU A 751
 None
 0.62A 4u0iA-3zfxA:
32.2		 4u0iA-3zfxA:
34.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 866
LEU A 889
CYH A 919
GLY A 922
CYH A1024
LEU A1035
CYH A1045
ASP A1046
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
 0.69A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 866
LEU A 889
CYH A 919
GLY A 922
HIS A1026
LEU A1035
CYH A1045
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
None
B49  A2000 (-4.2A)
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
B49  A2000 (-4.0A)
 0.67A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 868
LEU A 889
GLY A 922
CYH A1024
LEU A1035
CYH A1045
ASP A1046
 B49  A2000 (-3.0A)
None
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
 0.89A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LYS A 868
LEU A 889
GLY A 922
HIS A1026
LEU A1035
CYH A1045
ASP A1046
PHE A1047
 B49  A2000 (-3.0A)
None
B49  A2000 ( 3.7A)
None
B49  A2000 (-4.5A)
B49  A2000 ( 4.1A)
None
B49  A2000 (-4.0A)
 0.84A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  31
LYS A  33
LEU A  55
CYH A  83
CYH A 122
HIS A 124
LEU A 133
CYH A 143
 D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.3A)
None
None
D15  A 500 (-4.5A)
D15  A 500 ( 4.0A)
 0.56A 4u0iA-4aguA:
23.2		 4u0iA-4aguA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  31
LYS A  33
LEU A  55
CYH A  83
HIS A 124
LEU A 133
CYH A 143
ASP A 144
 D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.3A)
None
D15  A 500 (-4.5A)
D15  A 500 ( 4.0A)
D15  A 500 (-3.7A)
 0.72A 4u0iA-4aguA:
23.2		 4u0iA-4aguA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 ALA A 104
LYS A 106
LEU A 129
GLY A 160
HIS A 199
LEU A 208
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
None
None
None
EDO  A1420 ( 4.8A)
 0.48A 4u0iA-4aw2A:
19.8		 4u0iA-4aw2A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  63
LEU A  85
CYH A 113
GLY A 116
HIS A 155
LEU A 164
 XZN  A1317 (-3.5A)
None
XZN  A1317 (-3.7A)
XZN  A1317 ( 3.7A)
None
XZN  A1317 (-4.7A)
 0.42A 4u0iA-4bc6A:
20.8		 4u0iA-4bc6A:
29.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 653
LYS A 655
THR A 701
GLY A 707
HIS A 764
LEU A 773
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
None
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.78A 4u0iA-4ckrA:
33.8		 4u0iA-4ckrA:
32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 ALA A 588
LEU A 611
GLY A 642
CYH A 679
HIS A 681
LEU A 690
 GUI  A 901 (-3.4A)
None
GUI  A 901 (-3.5A)
None
None
GUI  A 901 (-4.3A)
 0.40A 4u0iA-4e93A:
32.8		 4u0iA-4e93A:
31.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
LEU A  59
CYH A  89
GLY A  92
HIS A 133
 BX7  A 401 (-3.4A)
BX7  A 401 ( 4.0A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.5A)
None
 0.64A 4u0iA-4eutA:
19.3		 4u0iA-4eutA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  36
LYS A  38
LEU A  59
CYH A  89
GLY A  92
HIS A 133
 BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
BX7  A 401 (-3.3A)
None
 0.60A 4u0iA-4euuA:
21.6		 4u0iA-4euuA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A 429
LYS A 431
GLY A 477
HIS A 515
LEU A 524
CYH A 535
 0WB  A 701 (-3.3A)
0WB  A 701 (-3.0A)
0WB  A 701 ( 4.5A)
None
0WB  A 701 (-4.3A)
0WB  A 701 ( 3.7A)
 0.62A 4u0iA-4g3fA:
21.9		 4u0iA-4g3fA:
22.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
LYS A 855
LEU A 875
GLY A 908
CYH A 945
HIS A 947
LEU A 956
 19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
None
None
19S  A1201 (-4.5A)
 0.66A 4u0iA-4hviA:
30.0		 4u0iA-4hviA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A  61
LYS A  63
LEU A  81
GLY A 110
HIS A 154
LEU A 163
CYH A 174
ASP A 175
 1UL  A 501 (-3.1A)
None
None
1UL  A 501 ( 3.7A)
None
1UL  A 501 (-4.3A)
1UL  A 501 (-3.6A)
1UL  A 501 (-4.2A)
 0.92A 4u0iA-4l52A:
19.5		 4u0iA-4l52A:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ALA A 388
LYS A 390
LEU A 406
CYH A 435
HIS A 480
LEU A 489
 None
 0.58A 4u0iA-4o1oA:
16.8		 4u0iA-4o1oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA A  67
LYS A  69
THR A 123
CYH A 126
GLY A 128
HIS A 171
LEU A 180
CYH A 190
 SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
None
 0.59A 4u0iA-4o38A:
20.7		 4u0iA-4o38A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LYS A  69
THR A 123
CYH A 126
GLY A 128
LEU A 180
CYH A 190
ASP A 191
 None
None
SIN  A 401 (-4.3A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
None
None
 0.77A 4u0iA-4o38A:
20.7		 4u0iA-4o38A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ALA B 390
LYS B 392
LEU B 408
CYH B 437
HIS B 483
LEU B 492
 ACP  B 801 (-3.2A)
ACP  B 801 (-2.8A)
None
ACP  B 801 (-4.5A)
None
ACP  B 801 (-4.5A)
 0.59A 4u0iA-4oavB:
17.4		 4u0iA-4oavB:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 ALA A  49
LYS A  51
LEU A  74
HIS A 147
LEU A 156
CYH A 166
ASP A 167
 ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
None
None
ANP  A 402 (-4.6A)
ANP  A 402 ( 4.3A)
ANP  A 402 ( 2.6A)
 0.80A 4u0iA-4qnyA:
21.6		 4u0iA-4qnyA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  69
LYS A  71
LEU A  92
HIS A 164
LEU A 173
CYH A 183
ASP A 184
 38Z  A 418 (-3.4A)
38Z  A 418 (-2.9A)
None
None
38Z  A 418 (-4.4A)
38Z  A 418 ( 3.8A)
38Z  A 418 (-3.5A)
 1.17A 4u0iA-4qtbA:
21.4		 4u0iA-4qtbA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 642
LYS A 644
CYH A 694
GLY A 697
CYH A 807
LEU A 818
CYH A 828
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
 0.56A 4u0iA-4rt7A:
32.3		 4u0iA-4rt7A:
47.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 642
LYS A 644
CYH A 694
GLY A 697
HIS A 809
LEU A 818
CYH A 828
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
None
P30  A1001 (-3.4A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
P30  A1001 (-4.1A)
None
P30  A1001 (-3.9A)
 0.34A 4u0iA-4rt7A:
32.3		 4u0iA-4rt7A:
47.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
LYS A  37
THR A  81
GLY A  87
HIS A 127
LEU A 136
ASP A 147
 ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.78A 4u0iA-4ueuA:
31.4		 4u0iA-4ueuA:
38.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  72
CYH A 129
GLY A 132
HIS A 174
LEU A 183
CYH A 193
 KSA  A 405 (-3.2A)
KSA  A 405 (-4.5A)
KSA  A 405 (-3.5A)
None
KSA  A 405 (-4.6A)
KSA  A 405 (-3.4A)
 0.54A 4u0iA-4wsqA:
22.6		 4u0iA-4wsqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		7 ALA A  50
LYS A  52
LEU A  73
HIS A 145
LEU A 154
CYH A 164
ASP A 165
 42A  A 402 (-3.2A)
42A  A 402 (-4.1A)
None
None
42A  A 402 ( 4.9A)
None
None
 0.99A 4u0iA-4xrlA:
21.3		 4u0iA-4xrlA:
25.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 642
LYS A 644
CYH A 694
GLY A 697
HIS A 809
LEU A 818
CYH A 828
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.2A)
P30  A1001 (-3.5A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
P30  A1001 (-4.8A)
None
P30  A1001 ( 4.1A)
 0.52A 4u0iA-4xufA:
39.1		 4u0iA-4xufA:
60.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		6 ALA A 428
LYS A 430
THR A 474
GLY A 480
HIS A 519
LEU A 528
 746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
746  A 702 (-3.6A)
None
746  A 702 (-4.4A)
 0.58A 4u0iA-4y93A:
30.3		 4u0iA-4y93A:
24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 488
LYS A 490
LEU A 513
THR A 539
GLY A 545
HIS A 586
LEU A 595
 4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
None
4CV  A 801 (-4.4A)
 0.81A 4u0iA-4yffA:
25.3		 4u0iA-4yffA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 ALA A  55
LYS A  57
LEU A  80
THR A 105
GLY A 111
HIS A 149
LEU A 158
 ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.68A 4u0iA-4ysjA:
22.6		 4u0iA-4ysjA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 512
LYS A 514
GLY A 567
CYH A 619
HIS A 621
LEU A 630
 38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
38O  A1769 (-3.4A)
None
None
38O  A1769 (-4.6A)
 0.54A 4u0iA-5a46A:
33.8		 4u0iA-5a46A:
43.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ALA A  90
LYS A  92
LEU A 114
HIS A 187
LEU A 196
CYH A 206
ASP A 207
 None
 1.07A 4u0iA-5ci6A:
20.3		 4u0iA-5ci6A:
24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  44
LYS A  46
LEU A  67
CYH A  95
GLY A  98
HIS A 136
LEU A 145
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
51W  A 401 (-3.9A)
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
 0.72A 4u0iA-5ci7A:
23.2		 4u0iA-5ci7A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
LYS A 277
THR A 325
GLY A 331
HIS A 377
LEU A 386
CYH A 396
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
None
STU  A 601 (-3.9A)
STU  A 601 (-3.2A)
 0.52A 4u0iA-5e8yA:
24.9		 4u0iA-5e8yA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
LYS A 277
THR A 325
HIS A 377
LEU A 386
CYH A 396
ASP A 397
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.7A)
None
STU  A 601 (-3.9A)
STU  A 601 (-3.2A)
STU  A 601 (-3.0A)
 0.85A 4u0iA-5e8yA:
24.9		 4u0iA-5e8yA:
28.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 ALA A 625
LYS A 627
THR A 674
CYH A 677
GLY A 680
CYH A 814
HIS A 816
LEU A 825
CYH A 835
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
748  A1001 ( 4.0A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.5A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.33A 4u0iA-5grnA:
33.9		 4u0iA-5grnA:
59.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  77
LYS A  79
CYH A 133
GLY A 136
HIS A 178
LEU A 187
CYH A 197
 IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
IDV  A 401 (-4.6A)
IDV  A 401 (-3.4A)
None
IDV  A 401 (-4.4A)
IDV  A 401 (-3.6A)
 0.77A 4u0iA-5i3oA:
22.6		 4u0iA-5i3oA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
LYS A  45
CYH A  93
GLY A  96
HIS A 134
LEU A 143
 6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
 0.55A 4u0iA-5j5tA:
21.0		 4u0iA-5j5tA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 228
LYS A 230
CYH A 286
GLY A 289
HIS A 329
LEU A 338
 6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
6UY  A 501 ( 4.3A)
None
6UY  A 501 (-4.5A)
 0.51A 4u0iA-5ko1A:
26.7		 4u0iA-5ko1A:
26.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 ALA A  38
LYS A  40
LEU A  61
CYH A  89
GLY A  92
HIS A 130
LEU A 139
 7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
None
7LV  A 401 (-4.3A)
None
None
7LV  A 401 (-4.9A)
 0.74A 4u0iA-5tvtA:
22.2		 4u0iA-5tvtA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 7 ALA A  38
LYS A  40
LEU A  61
CYH A  89
GLY A  92
LEU A 139
ASP A 150
 7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
None
7LV  A 401 (-4.3A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 0.86A 4u0iA-5tvtA:
22.2		 4u0iA-5tvtA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 150
LYS A 152
CYH A 193
GLY A 196
HIS A 234
LEU A 243
ASP A 254
 9FS  A 501 (-3.4A)
None
9FS  A 501 (-4.3A)
9FS  A 501 (-3.6A)
None
9FS  A 501 (-4.7A)
None
 0.82A 4u0iA-5vo1A:
24.9		 4u0iA-5vo1A:
29.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ALA A 192
LYS A 194
LEU A 240
GLY A 273
HIS A 310
LEU A 319
ASP A 330
 BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
None
BI9  A 501 (-3.3A)
None
BI9  A 501 (-4.7A)
None
 0.99A 4u0iA-6bqlA:
21.6		 4u0iA-6bqlA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 ALA A 906
LYS A 908
LEU A 929
GLY A 962
HIS A1001
LEU A1010
 ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
None
ADP  A1201 (-4.5A)
 0.65A 4u0iA-6c7yA:
28.1		 4u0iA-6c7yA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 7 ALA A 715
LEU A 736
HIS A 813
LEU A 822
CYH A 833
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
None
919  A1101 (-4.2A)
None
919  A1101 (-4.1A)
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.83A 4u0iA-6cnhA:
21.4		 4u0iA-6cnhA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 ALA A 217
THR A 264
GLY A 270
HIS A 310
LEU A 319
ASP A 330
PHE A 331
 FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.9A)
FKY  A9001 ( 4.9A)
None
FKY  A9001 (-3.9A)
 0.79A 4u0iA-6cz4A:
29.1		 4u0iA-6cz4A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 ALA A 191
LYS A 193
LEU A 212
GLY A 247
HIS A 288
LEU A 297
ASP A 327
 3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
None
None
None
3NG  A 501 (-4.5A)
 1.15A 4u0iA-6fylA:
22.4		 4u0iA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 ALA A 189
LYS A 191
LEU A 210
GLY A 245
HIS A 286
LEU A 295
ASP A 325
 3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
None
None
None
None
3NG  A 501 (-4.3A)
 1.17A 4u0iA-6fyvA:
22.3		 4u0iA-6fyvA:
undetectable