SIMILAR PATTERNS OF AMINO ACIDS FOR 4U0I_A_0LIA1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  70
GLU A  97
LEU A 104
ILE A 109
VAL A 110
TYR A 134
 None
 0.82A 4u0iA-1gngA:
20.4		 4u0iA-1gngA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 209
GLU A 236
LEU A 243
VAL A 249
TYR A 268
ARG A 313
 None
 0.87A 4u0iA-1k9aA:
31.3		 4u0iA-1k9aA:
27.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 VAL A 588
ILE A 637
VAL A 638
TYR A 656
ARG A 723
ILE A 740
 None
 0.82A 4u0iA-1lufA:
36.3		 4u0iA-1lufA:
36.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		6 VAL A  53
GLU A  81
LEU A  88
ILE A  94
VAL A  95
TYR A 115
 HNA  A 351 (-4.5A)
None
None
None
None
None
 0.84A 4u0iA-1m2pA:
21.8		 4u0iA-1m2pA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 219
GLU A 245
LEU A 254
ILE A 259
TYR A 282
ARG A 332
ILE A 349
 PY1  A 700 ( 4.7A)
PY1  A 700 ( 4.9A)
None
None
PY1  A 700 (-4.6A)
None
None
 1.01A 4u0iA-1py5A:
25.7		 4u0iA-1py5A:
27.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
GLU A 661
LEU A 668
ILE A 674
VAL A 675
TYR A 693
ILE A 827
 None
 0.78A 4u0iA-1rjbA:
39.8		 4u0iA-1rjbA:
55.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 595
VAL A 603
GLU A 640
LEU A 647
ILE A 653
VAL A 654
VAL A 668
TYR A 672
ARG A 791
ILE A 808
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
STI  A   3 (-3.6A)
None
None
STI  A   3 (-4.3A)
STI  A   3 (-4.6A)
STI  A   3 ( 4.0A)
None
None
 0.37A 4u0iA-1t46A:
35.8		 4u0iA-1t46A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
VAL A 352
GLU A 386
LEU A 393
ILE A 398
VAL A 399
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
None
None
None
None
None
 0.65A 4u0iA-1u59A:
31.1		 4u0iA-1u59A:
35.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 VAL A  18
LEU A  57
ILE A  62
VAL A  63
ARG A 124
ILE A 141
 None
 0.86A 4u0iA-1v0bA:
21.4		 4u0iA-1v0bA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
GLU A  55
LEU A  62
VAL A  68
TYR A  86
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
None
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
None
 0.89A 4u0iA-1zltA:
20.9		 4u0iA-1zltA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  15
VAL A  23
LEU A  62
VAL A  68
TYR A  86
ARG A 129
ILE A 146
 HYM  A 400 (-4.2A)
HYM  A 400 (-4.3A)
None
HYM  A 400 (-4.8A)
HYM  A 400 (-4.7A)
SO4  A 901 (-2.9A)
None
 0.88A 4u0iA-1zltA:
20.9		 4u0iA-1zltA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A 605
VAL A 613
LEU A 650
VAL A 656
TYR A 790
ILE A 851
 None
None
None
GOL  A 998 (-4.9A)
GOL  A 998 (-4.6A)
None
 0.82A 4u0iA-1zy4A:
20.2		 4u0iA-1zy4A:
27.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL B 281
GLU B 308
LEU B 315
ILE B 320
VAL B 321
ILE B 430
 None
 0.75A 4u0iA-2a1aB:
21.3		 4u0iA-2a1aB:
29.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
GLU X  54
LEU X  61
VAL X  67
TYR X  84
ILE X 146
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.6A)
None
 0.70A 4u0iA-2dq7X:
31.3		 4u0iA-2dq7X:
35.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
VAL X  25
LEU X  61
VAL X  67
TYR X  84
ARG X 129
ILE X 146
 STU  X 902 (-3.8A)
STU  X 902 ( 4.8A)
None
None
STU  X 902 (-4.6A)
PTR  X 160 ( 3.4A)
None
 0.83A 4u0iA-2dq7X:
31.3		 4u0iA-2dq7X:
35.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 348
VAL A 356
GLU A 390
TYR A 422
ARG A 465
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
None
PDS  A 901 (-4.7A)
TPO  A 500 ( 2.9A)
None
 0.82A 4u0iA-2i0eA:
20.2		 4u0iA-2i0eA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
GLU A  65
LEU A  72
ILE A  77
TYR A 110
ILE A 169
 None
 0.86A 4u0iA-2i6lA:
22.0		 4u0iA-2i6lA:
27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  34
LEU A  72
ILE A  77
VAL A  78
TYR A 110
ILE A 169
 None
 0.79A 4u0iA-2i6lA:
22.0		 4u0iA-2i6lA:
27.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
GLU A 288
LEU A 295
VAL A 301
TYR A 318
ARG A 363
ILE A 380
 None
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.9A)
None
1N8  A 501 ( 3.7A)
None
None
 0.72A 4u0iA-2og8A:
31.4		 4u0iA-2og8A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
VAL A 259
GLU A 288
VAL A 301
TYR A 318
ARG A 363
ILE A 380
 None
None
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 3.7A)
None
None
 0.75A 4u0iA-2og8A:
31.4		 4u0iA-2og8A:
37.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 588
VAL A 596
GLU A 633
ILE A 646
VAL A 647
VAL A 661
TYR A 665
ARG A 777
ILE A 794
 None
 0.85A 4u0iA-2ogvA:
39.8		 4u0iA-2ogvA:
67.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 588
VAL A 596
GLU A 633
LEU A 640
ILE A 646
VAL A 661
TYR A 665
ARG A 777
 None
 0.79A 4u0iA-2ogvA:
39.8		 4u0iA-2ogvA:
67.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 344
VAL A 352
LEU A 393
ILE A 398
VAL A 399
ILE A 477
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
None
None
None
None
 0.88A 4u0iA-2ozoA:
26.6		 4u0iA-2ozoA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 487
VAL A 495
GLU A 534
ILE A 547
VAL A 562
TYR A 566
ARG A 625
ILE A 642
 None
None
None
None
None
None
SO4  A 303 ( 2.9A)
None
 0.87A 4u0iA-2psqA:
33.8		 4u0iA-2psqA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
GLU A 534
VAL A 562
TYR A 566
ARG A 625
ILE A 547
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
 1.43A 4u0iA-2psqA:
33.8		 4u0iA-2psqA:
45.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 313
GLU A 346
LEU A 353
VAL A 360
TYR A 378
ILE A 461
 770  A 901 ( 4.7A)
770  A 901 (-3.9A)
None
770  A 901 ( 4.7A)
770  A 901 (-4.2A)
None
 0.75A 4u0iA-2z2wA:
15.6		 4u0iA-2z2wA:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1002
VAL A1010
GLU A1047
VAL A1060
VAL A1074
ILE A1148
 S91  A   1 ( 4.1A)
S91  A   1 ( 4.9A)
None
None
None
None
 0.83A 4u0iA-2z8cA:
30.0		 4u0iA-2z8cA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  97
VAL A 105
GLU A 143
ILE A 155
VAL A 156
TYR A 174
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
None
STU  A 400 (-4.7A)
 0.51A 4u0iA-3a62A:
21.8		 4u0iA-3a62A:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
VAL A 495
GLU A 534
ILE A 547
VAL A 562
TYR A 566
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
None
M33  A1996 ( 4.7A)
None
 0.74A 4u0iA-3b2tA:
33.8		 4u0iA-3b2tA:
48.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
GLU A 534
ILE A 547
VAL A 562
TYR A 566
ARG A 625
ILE A 642
 M33  A1996 ( 4.7A)
None
None
None
M33  A1996 ( 4.7A)
None
None
 0.97A 4u0iA-3b2tA:
33.8		 4u0iA-3b2tA:
48.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
GLU A 531
ILE A 544
VAL A 559
TYR A 563
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
None
None
None
None
 0.64A 4u0iA-3c4fA:
33.0		 4u0iA-3c4fA:
48.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 209
GLU A 236
LEU A 243
VAL A 249
TYR A 268
ARG A 313
 None
 0.87A 4u0iA-3d7uA:
26.3		 4u0iA-3d7uA:
34.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3p PROTEIN KINASE,
PUTATIVE GLYCOGEN
SYNTHASE KINASE

(Leishmania
major) 		PF00069
(Pkinase) 		6 VAL A  34
GLU A  61
LEU A  68
ILE A  76
VAL A  77
VAL A  98
 None
 0.78A 4u0iA-3e3pA:
19.1		 4u0iA-3e3pA:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
GLU A  50
ILE A  62
VAL A 115
TYR A 119
 DRK  A 384 (-3.8A)
None
None
None
None
DRK  A 384 (-4.4A)
 0.60A 4u0iA-3eb0A:
20.9		 4u0iA-3eb0A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe3 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 3

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
LEU A 110
ILE A 115
VAL A 116
TYR A 134
ILE A 194
 None
 0.85A 4u0iA-3fe3A:
22.1		 4u0iA-3fe3A:
27.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 833
VAL A 841
GLU A 878
VAL A 892
VAL A 907
TYR A 911
ILE A1038
 8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.6A)
8ST  A2001 (-3.7A)
8ST  A2001 ( 4.7A)
8ST  A2001 (-4.5A)
8ST  A2001 (-4.9A)
None
 0.48A 4u0iA-3hngA:
41.4		 4u0iA-3hngA:
48.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 LEU A 107
ILE A 112
VAL A 113
TYR A 131
ARG A 174
ILE A 191
 None
 0.83A 4u0iA-3iecA:
21.9		 4u0iA-3iecA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  67
LEU A 107
ILE A 112
VAL A 113
TYR A 131
ILE A 191
 None
 0.70A 4u0iA-3iecA:
21.9		 4u0iA-3iecA:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 VAL A 218
GLU A 244
ILE A 258
TYR A 281
ARG A 331
ILE A 348
 LDN  A   1 ( 4.8A)
None
None
LDN  A   1 ( 4.8A)
None
None
 0.88A 4u0iA-3mdyA:
25.2		 4u0iA-3mdyA:
27.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
VAL A  96
GLU A 130
VAL A 143
TYR A 161
ILE A 221
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
SO4  A   5 (-3.1A)
None
None
None
 0.55A 4u0iA-3nuuA:
23.1		 4u0iA-3nuuA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  88
VAL A  96
VAL A 143
TYR A 161
ARG A 204
ILE A 221
 JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.7A)
None
None
SEP  A 241 ( 3.4A)
None
 0.81A 4u0iA-3nuuA:
23.1		 4u0iA-3nuuA:
25.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
GLU A 531
ILE A 544
VAL A 559
TYR A 563
ILE A 639
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.6A)
07J  A   1 (-4.7A)
None
 0.67A 4u0iA-3tt0A:
33.6		 4u0iA-3tt0A:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLU A 588
LEU A 595
ILE A 600
VAL A 601
ARG A 678
ILE A 695
 0F4  A 902 (-3.6A)
0F4  A 902 ( 4.8A)
0F4  A 902 (-4.1A)
None
None
0F4  A 902 (-4.6A)
 0.89A 4u0iA-3v5qA:
28.7		 4u0iA-3v5qA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
VAL A 552
LEU A 595
ILE A 600
VAL A 601
TYR A 619
ILE A 695
 0F4  A 902 ( 4.2A)
None
0F4  A 902 ( 4.8A)
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.2A)
0F4  A 902 (-4.6A)
 0.68A 4u0iA-3v5qA:
28.7		 4u0iA-3v5qA:
35.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
GLU A 885
VAL A 899
VAL A 914
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
None
None
 0.61A 4u0iA-3vidA:
36.1		 4u0iA-3vidA:
47.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 139
VAL A 147
LEU A 188
ILE A 193
TYR A 212
ILE A 272
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
None
None
N13  A 501 (-4.4A)
None
 0.75A 4u0iA-3w18A:
22.0		 4u0iA-3w18A:
25.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 840
VAL A 848
GLU A 885
VAL A 899
VAL A 914
ARG A1027
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.7A)
None
None
None
None
 0.75A 4u0iA-3wzdA:
35.3		 4u0iA-3wzdA:
53.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  59
LEU A 108
VAL A 114
VAL A 128
ARG A 175
ILE A 192
 939  A1331 (-3.7A)
None
None
None
None
None
 0.82A 4u0iA-4a4lA:
22.8		 4u0iA-4a4lA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
VAL A  91
LEU A 132
ILE A 137
TYR A 156
ILE A 216
 VX6  A 500 (-3.8A)
VX6  A 500 ( 4.8A)
None
None
VX6  A 500 (-4.2A)
None
 0.78A 4u0iA-4af3A:
19.8		 4u0iA-4af3A:
26.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 840
VAL A 848
GLU A 885
VAL A 899
VAL A 914
ILE A1044
 B49  A2000 (-3.7A)
None
None
B49  A2000 ( 4.6A)
None
None
 0.46A 4u0iA-4agdA:
41.5		 4u0iA-4agdA:
49.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 560
VAL A 568
ILE A 616
VAL A 617
TYR A 635
ARG A 691
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
None
LTI  A1839 (-4.7A)
None
None
 1.18A 4u0iA-4at3A:
32.6		 4u0iA-4at3A:
33.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 560
VAL A 568
LEU A 611
ILE A 616
VAL A 617
TYR A 635
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
None
None
LTI  A1839 (-4.7A)
None
 0.88A 4u0iA-4at3A:
32.6		 4u0iA-4at3A:
33.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 LEU A 246
VAL A 254
GLU A 288
LEU A 295
TYR A 320
ILE A 380
 None
 0.87A 4u0iA-4c0tA:
22.6		 4u0iA-4c0tA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
ILE A  76
TYR A  95
ARG A 138
ILE A 155
 STU  A1550 (-4.3A)
None
None
STU  A1550 (-4.5A)
TPO  A 172 ( 2.4A)
None
 0.78A 4u0iA-4cfhA:
22.3		 4u0iA-4cfhA:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
GLU A 672
LEU A 679
ILE A 684
TYR A 703
ARG A 765
ILE A 782
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 ( 4.5A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.90A 4u0iA-4ckrA:
33.8		 4u0iA-4ckrA:
32.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		6 LEU A 663
VAL A 671
GLU A 705
VAL A 721
TYR A 739
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
None
None
None
None
 0.67A 4u0iA-4crsA:
21.0		 4u0iA-4crsA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		7 LEU A  16
VAL A  24
LEU A  65
ILE A  70
VAL A  71
TYR A  89
ILE A 149
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.7A)
None
None
None
ANP  A 300 (-4.3A)
None
 0.80A 4u0iA-4eqmA:
21.7		 4u0iA-4eqmA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  15
VAL A  23
LEU A  62
ILE A  67
VAL A  68
ARG A 134
 BX7  A 401 (-3.7A)
BX7  A 401 (-4.4A)
None
None
None
None
 0.88A 4u0iA-4eutA:
19.2		 4u0iA-4eutA:
23.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 515
VAL A 523
LEU A 566
ILE A 571
VAL A 572
TYR A 590
ILE A 665
 None
 0.88A 4u0iA-4f0iA:
33.9		 4u0iA-4f0iA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 523
LEU A 566
ILE A 571
VAL A 572
TYR A 590
ARG A 648
ILE A 665
 None
 1.04A 4u0iA-4f0iA:
33.9		 4u0iA-4f0iA:
36.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 377
VAL A 385
GLU A 420
LEU A 427
ILE A 432
VAL A 433
ILE A 510
 0SB  A 701 ( 3.9A)
0SB  A 701 (-4.0A)
None
None
None
None
None
 0.83A 4u0iA-4f4pA:
30.1		 4u0iA-4f4pA:
35.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		7 LEU A 377
VAL A 385
LEU A 427
ILE A 432
VAL A 433
ARG A 493
ILE A 510
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
None
None
ANP  A 701 (-4.8A)
None
None
 0.79A 4u0iA-4fl3A:
28.6		 4u0iA-4fl3A:
21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
VAL A1130
GLU A1167
ILE A1179
VAL A1180
ILE A1268
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
0UV  A1501 ( 4.9A)
None
 0.77A 4u0iA-4fodA:
30.7		 4u0iA-4fodA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
VAL A 863
GLU A 898
LEU A 905
ILE A 910
VAL A 911
TYR A 931
ILE A 992
 IZA  A2001 (-3.7A)
None
None
None
None
None
None
None
 0.75A 4u0iA-4gl9A:
16.6		 4u0iA-4gl9A:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
VAL A 836
GLU A 871
LEU A 878
ILE A 883
VAL A 884
TYR A 904
ILE A 965
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
None
None
None
None
19S  A1201 (-4.7A)
None
 0.64A 4u0iA-4hviA:
30.0		 4u0iA-4hviA:
32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
VAL A 486
GLU A 525
ILE A 538
VAL A 553
TYR A 557
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 ( 4.8A)
None
None
None
None
 0.50A 4u0iA-4k33A:
34.3		 4u0iA-4k33A:
49.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ILE A 538
VAL A 553
TYR A 557
ARG A 616
ILE A 633
 ACP  A 801 (-4.2A)
None
None
None
None
None
 0.85A 4u0iA-4k33A:
34.3		 4u0iA-4k33A:
49.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
GLU A  77
ILE A  89
VAL A  90
TYR A 106
ILE A 173
 1UL  A 501 ( 4.9A)
None
None
None
1UL  A 501 (-4.1A)
None
 0.73A 4u0iA-4l52A:
19.5		 4u0iA-4l52A:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  78
VAL A  86
LEU A 124
ILE A 129
VAL A 130
ILE A 211
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
None
None
None
None
 0.69A 4u0iA-4mvfA:
19.0		 4u0iA-4mvfA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  46
VAL A  54
GLU A  85
LEU A  92
ILE A  98
VAL A  99
 SIN  A 401 ( 3.9A)
None
None
None
None
None
 0.68A 4u0iA-4o38A:
20.7		 4u0iA-4o38A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
GLU A 947
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
None
2TT  A1202 (-4.6A)
None
 0.75A 4u0iA-4oliA:
27.2		 4u0iA-4oliA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  24
VAL A  32
ILE A  78
TYR A  97
ARG A 140
ILE A 157
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
None
STU  A 601 (-4.4A)
None
None
 0.87A 4u0iA-4rewA:
22.1		 4u0iA-4rewA:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
GLU A 661
LEU A 668
ILE A 674
VAL A 675
TYR A 693
ILE A 827
 P30  A1001 (-3.8A)
None
P30  A1001 (-3.6A)
None
None
None
P30  A1001 (-4.1A)
P30  A1001 ( 4.8A)
 0.69A 4u0iA-4rt7A:
32.3		 4u0iA-4rt7A:
47.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
GLU A  52
LEU A  59
VAL A  65
TYR A  83
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
None
ACP  A1264 ( 4.5A)
 0.83A 4u0iA-4ueuA:
31.4		 4u0iA-4ueuA:
38.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		6 LEU A  14
VAL A  22
GLU A  52
VAL A  65
TYR A  83
ARG A 128
 ACP  A1264 ( 4.5A)
ACP  A1264 (-4.7A)
None
None
ACP  A1264 ( 4.5A)
None
 0.86A 4u0iA-4ueuA:
31.4		 4u0iA-4ueuA:
38.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
VAL A 201
GLU A 235
ILE A 247
VAL A 248
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
None
 0.81A 4u0iA-4wboA:
22.4		 4u0iA-4wboA:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
GLU A 520
ILE A 533
VAL A 548
ARG A 611
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 (-3.7A)
None
40M  A1002 (-4.6A)
None
None
 0.76A 4u0iA-4xcuA:
33.4		 4u0iA-4xcuA:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 473
VAL A 481
GLU A 520
ILE A 533
VAL A 548
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
40M  A1002 (-3.7A)
None
40M  A1002 (-4.6A)
None
 0.67A 4u0iA-4xcuA:
33.4		 4u0iA-4xcuA:
48.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
ILE A 674
VAL A 675
TYR A 693
ARG A 810
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.4A)
None
P30  A1001 (-4.7A)
 0.83A 4u0iA-4xufA:
39.1		 4u0iA-4xufA:
60.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
VAL A 624
GLU A 661
LEU A 668
ILE A 674
VAL A 675
TYR A 693
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.7A)
 0.64A 4u0iA-4xufA:
39.1		 4u0iA-4xufA:
60.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
VAL A  42
GLU A  76
LEU A  83
ILE A  88
ILE A 170
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
None
None
None
None
 0.72A 4u0iA-4ysjA:
22.6		 4u0iA-4ysjA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  34
VAL A  42
LEU A  83
ILE A  88
ARG A 150
ILE A 170
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
None
None
None
None
 0.79A 4u0iA-4ysjA:
22.6		 4u0iA-4ysjA:
19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
GLU A 531
ILE A 544
VAL A 559
TYR A 563
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
EDO  A1766 (-4.1A)
None
None
38O  A1769 (-4.2A)
None
 0.57A 4u0iA-5a46A:
33.8		 4u0iA-5a46A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 484
VAL A 492
GLU A 531
VAL A 559
TYR A 563
ARG A 622
ILE A 639
 38O  A1769 (-3.2A)
38O  A1769 (-4.5A)
EDO  A1766 (-4.1A)
None
38O  A1769 (-4.2A)
None
None
 0.94A 4u0iA-5a46A:
33.8		 4u0iA-5a46A:
43.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
LEU A  70
ILE A  75
VAL A  76
TYR A  94
ARG A 137
ILE A 163
 51W  A 401 ( 4.3A)
None
None
None
51W  A 401 ( 3.4A)
TPO  A 180 ( 2.9A)
None
 0.69A 4u0iA-5ci7A:
23.2		 4u0iA-5ci7A:
30.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
GLU A 103
LEU A 110
ILE A 115
TYR A 134
ILE A 194
 5RC  A4000 (-4.6A)
None
None
None
5RC  A4000 (-4.5A)
None
 0.82A 4u0iA-5es1A:
22.5		 4u0iA-5es1A:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 VAL A  70
LEU A 110
ILE A 115
VAL A 116
TYR A 134
ILE A 194
 5RC  A4000 (-4.6A)
None
None
None
5RC  A4000 (-4.5A)
None
 0.61A 4u0iA-5es1A:
22.5		 4u0iA-5es1A:
27.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
VAL A 911
GLU A 947
LEU A 954
ILE A 959
TYR A 980
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
None
None
5U3  A1200 (-4.5A)
None
 0.67A 4u0iA-5f1zA:
28.0		 4u0iA-5f1zA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 599
VAL A 607
GLU A 644
LEU A 651
ILE A 657
VAL A 658
TYR A 676
ARG A 817
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 (-3.3A)
None
748  A1001 ( 4.4A)
748  A1001 ( 4.8A)
748  A1001 (-4.0A)
None
748  A1001 (-4.8A)
 0.56A 4u0iA-5grnA:
33.9		 4u0iA-5grnA:
59.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		6 LEU A  20
VAL A  28
GLU A  61
LEU A  68
ILE A  73
VAL A  74
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.7A)
None
None
None
None
 0.77A 4u0iA-5hu3A:
23.0		 4u0iA-5hu3A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
VAL A  65
LEU A 102
ILE A 108
VAL A 109
TYR A 132
ARG A 179
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
None
None
None
IDV  A 401 (-3.5A)
None
 0.88A 4u0iA-5i3oA:
22.6		 4u0iA-5i3oA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 VAL A  32
GLU A  65
LEU A  72
ILE A  77
TYR A  96
ILE A 159
 None
None
None
None
PO4  A 401 (-4.8A)
None
 0.84A 4u0iA-5ig1A:
22.8		 4u0iA-5ig1A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		6 VAL A  32
LEU A  72
ILE A  77
VAL A  78
TYR A  96
ILE A 159
 None
None
None
None
PO4  A 401 (-4.8A)
None
 0.81A 4u0iA-5ig1A:
22.8		 4u0iA-5ig1A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		6 LEU A  22
VAL A  30
ILE A  76
TYR A  95
ARG A 138
ILE A 155
 STU  A 601 (-4.1A)
STU  A 601 (-4.8A)
None
STU  A 601 (-4.3A)
None
None
 0.80A 4u0iA-5isoA:
22.3		 4u0iA-5isoA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u94 SERINE/THREONINE-PRO
TEIN KINASE PKNB

(Mycobacterium
tuberculosis) 		no annotation 8 LEU A  17
VAL A  25
GLU A  59
LEU A  66
ILE A  71
VAL A  72
TYR A  94
ARG A 137
 G93  A 301 ( 3.8A)
G93  A 301 (-3.4A)
G93  A 301 (-3.2A)
None
None
G93  A 301 (-4.0A)
None
None
 0.95A 4u0iA-5u94A:
24.8		 4u0iA-5u94A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 LEU A 686
VAL A 694
GLU A 725
LEU A 732
ILE A 737
VAL A 738
ILE A 820
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
None
None
None
9E1  A1001 (-4.1A)
None
 0.84A 4u0iA-5vilA:
24.2		 4u0iA-5vilA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53

(Saccharomyces
cerevisiae) 		no annotation 6 VAL A 212
GLU A 244
LEU A 251
ILE A 256
VAL A 257
ILE A 337
 None
 0.90A 4u0iA-5xzwA:
19.2		 4u0iA-5xzwA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 7 LEU A 881
VAL A 889
GLU A 925
LEU A 932
ILE A 937
VAL A 938
ILE A1019
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
None
None
None
None
None
 0.68A 4u0iA-6c7yA:
28.1		 4u0iA-6c7yA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
GLU A 107
LEU A 114
ILE A 119
VAL A 120
TYR A 138
ILE A 198
 None
 0.83A 4u0iA-6c9dA:
21.3		 4u0iA-6c9dA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
LEU A 114
ILE A 119
VAL A 120
TYR A 138
ARG A 181
ILE A 198
 None
 0.82A 4u0iA-6c9dA:
21.3		 4u0iA-6c9dA:
12.38