SIMILAR PATTERNS OF AMINO ACIDS FOR 4TZU_D_Y70D503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus)
PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18)
4 TRP B 382
TRP B 388
TRP B 402
PHE B 404
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
0.34A 4tzuD-4ci2B:
17.8
4tzuD-4ci2B:
90.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tzc PROTEIN CEREBLON

(Mus musculus)
no annotation 5 HIS C 380
TRP C 382
TRP C 388
TRP C 402
PHE C 404
EF2  C 502 ( 4.9A)
EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
0.18A 4tzuD-4tzcC:
20.3
4tzuD-4tzcC:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb PROTEIN CEREBLON

(Homo sapiens)
no annotation 4 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
0.48A 4tzuD-5hxbZ:
10.0
4tzuD-5hxbZ:
97.22