SIMILAR PATTERNS OF AMINO ACIDS FOR 4TZC_D_EF2D505_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h81 POLYAMINE OXIDASE

(Zea mays) 		PF01593
(Amino_oxidase) 		4 TYR A 298
THR A 402
TRP A  60
PHE A 318
 FAD  A 579 (-4.4A)
FAD  A 579 (-4.0A)
None
None
 1.42A 4tzcB-1h81A:
undetectable
4tzcD-1h81A:
0.0		 4tzcB-1h81A:
16.15
4tzcD-1h81A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzh PHOSPHOFRUCTOKINASE

(Borreliella
burgdorferi) 		PF00365
(PFK) 		4 TYR A 527
THR A 266
HIS A 246
TRP A 245
 None
 1.25A 4tzcB-1kzhA:
0.0
4tzcD-1kzhA:
0.0		 4tzcB-1kzhA:
13.32
4tzcD-1kzhA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1c MAJOR COAT PROTEIN

(Saccharomyces
cerevisiae
virus L-A) 		PF09220
(LA-virus_coat) 		4 TRP A 545
HIS A 547
TRP A 510
PHE A 386
 None
 0.91A 4tzcB-1m1cA:
undetectable
4tzcD-1m1cA:
undetectable		 4tzcB-1m1cA:
8.51
4tzcD-1m1cA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 THR A 227
HIS A 180
TRP A 194
PHE A 193
 None
G6D  A 505 ( 3.7A)
None
None
 1.35A 4tzcB-1ua7A:
0.0
4tzcD-1ua7A:
0.0		 4tzcB-1ua7A:
13.88
4tzcD-1ua7A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bac PUTATIVE
AMINOOXIDASE

(Cutibacterium
acnes) 		PF01593
(Amino_oxidase) 		4 TYR A  67
THR A 189
HIS A 413
PHE A 209
 FAD  A 500 ( 4.8A)
None
None
None
 1.46A 4tzcB-2bacA:
undetectable
4tzcD-2bacA:
undetectable		 4tzcB-2bacA:
11.69
4tzcD-2bacA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is7 ALDOSE REDUCTASE

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 THR A 140
HIS A 306
TRP A  79
PHE A 122
 None
None
None
2CL  A 317 ( 4.9A)
 1.47A 4tzcB-2is7A:
0.0
4tzcD-2is7A:
0.0		 4tzcB-2is7A:
15.46
4tzcD-2is7A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3

(Zea mays) 		PF00161
(RIP) 		4 TYR A  74
THR A  85
TRP A 105
TRP A  72
 None
 1.32A 4tzcB-2pqiA:
0.3
4tzcD-2pqiA:
0.1		 4tzcB-2pqiA:
17.84
4tzcD-2pqiA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 TYR A  56
THR A 107
HIS A  51
TRP A  52
 None
None
BEZ  A 501 ( 4.5A)
None
 1.50A 4tzcB-2q6uA:
0.0
4tzcD-2q6uA:
undetectable		 4tzcB-2q6uA:
12.53
4tzcD-2q6uA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 THR A 414
HIS A 615
TRP A 610
PHE A 619
 None
 1.33A 4tzcB-2wanA:
0.4
4tzcD-2wanA:
0.8		 4tzcB-2wanA:
7.83
4tzcD-2wanA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya1 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF03714
(PUD) 		4 TYR A 667
TRP A 665
HIS A 594
PHE A 939
 BGC  A2144 (-4.5A)
None
None
None
 1.13A 4tzcB-2ya1A:
undetectable
4tzcD-2ya1A:
undetectable		 4tzcB-2ya1A:
6.68
4tzcD-2ya1A:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 TYR A 212
TRP A 210
HIS A 139
PHE A 484
 NOJ  A1689 ( 3.9A)
None
None
None
 1.15A 4tzcB-2ya2A:
undetectable
4tzcD-2ya2A:
undetectable		 4tzcB-2ya2A:
9.43
4tzcD-2ya2A:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 TYR A 547
TRP A 545
HIS A 418
PHE A 862
 None
 1.10A 4tzcB-2yocA:
undetectable
4tzcD-2yocA:
undetectable		 4tzcB-2yocA:
6.72
4tzcD-2yocA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auv SC-DSFV DERIVED FROM
THE G6-FAB

(Homo sapiens) 		PF07686
(V-set) 		4 TYR A 193
TRP A 181
TRP A 167
PHE A 235
 None
 1.37A 4tzcB-3auvA:
undetectable
4tzcD-3auvA:
undetectable		 4tzcB-3auvA:
18.42
4tzcD-3auvA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ii6 DNA LIGASE 4

(Homo sapiens) 		PF00533
(BRCT)
PF11411
(DNA_ligase_IV) 		4 TYR X 698
THR X 697
TRP X 725
TRP X 738
 None
 1.48A 4tzcB-3ii6X:
undetectable
4tzcD-3ii6X:
undetectable		 4tzcB-3ii6X:
18.29
4tzcD-3ii6X:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k81 SINGLE STRAND
ANTIBODY VHH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 THR A 115
TRP A  36
TRP A  34
PHE A  29
 None
 1.16A 4tzcB-3k81A:
undetectable
4tzcD-3k81A:
undetectable		 4tzcB-3k81A:
19.55
4tzcD-3k81A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lif PUTATIVE DIGUANYLATE
CYCLASE (GGDEF) WITH
PAS/PAC DOMAIN

(Rhodopseudomonas
palustris) 		PF02743
(dCache_1) 		4 TYR A 269
THR A 150
HIS A 212
PHE A 193
 None
 1.37A 4tzcB-3lifA:
undetectable
4tzcD-3lifA:
undetectable		 4tzcB-3lifA:
18.99
4tzcD-3lifA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 TYR A 755
THR A 769
HIS A 320
TRP A 752
 None
 1.34A 4tzcB-3qdeA:
undetectable
4tzcD-3qdeA:
undetectable		 4tzcB-3qdeA:
10.87
4tzcD-3qdeA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4d LACTOSE
PHOSPHORYLASE

(Cellulomonas
uda) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 TYR A 710
THR A 731
HIS A 703
PHE A   6
 None
SO4  A 823 (-3.6A)
None
None
 1.41A 4tzcB-3s4dA:
undetectable
4tzcD-3s4dA:
undetectable		 4tzcB-3s4dA:
8.22
4tzcD-3s4dA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5u RAUCAFFRICINE-O-BETA
-D-GLUCOSIDASE

(Rauvolfia
serpentina) 		PF00232
(Glyco_hydro_1) 		4 TYR A 200
THR A 197
TRP A 392
PHE A 485
 None
 1.19A 4tzcB-3u5uA:
undetectable
4tzcD-3u5uA:
undetectable		 4tzcB-3u5uA:
11.18
4tzcD-3u5uA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1v 2-METHYLISOBORNEOL
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 4 THR A 341
TRP A 419
HIS A 174
TRP A 426
 None
 1.39A 4tzcB-3v1vA:
undetectable
4tzcD-3v1vA:
undetectable		 4tzcB-3v1vA:
11.40
4tzcD-3v1vA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vvl HOMOSERINE
O-ACETYLTRANSFERASE

(Streptomyces
lavendulae) 		PF00561
(Abhydrolase_1) 		4 THR A  83
HIS A  58
TRP A  70
TRP A  71
 None
 1.41A 4tzcB-3vvlA:
undetectable
4tzcD-3vvlA:
undetectable		 4tzcB-3vvlA:
13.86
4tzcD-3vvlA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zph CHALCONE ISOMERASE

(Eubacterium
ramulus) 		no annotation 4 TYR A  48
HIS A  74
TRP A  75
PHE A 137
 None
 1.06A 4tzcB-3zphA:
undetectable
4tzcD-3zphA:
undetectable		 4tzcB-3zphA:
17.14
4tzcD-3zphA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 TYR A 357
TRP A 355
HIS A 260
PHE A 682
 GOL  A1888 (-3.9A)
None
None
None
 1.11A 4tzcB-4aioA:
undetectable
4tzcD-4aioA:
undetectable		 4tzcB-4aioA:
8.40
4tzcD-4aioA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		4 TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.21A 4tzcB-4ci2B:
16.9
4tzcD-4ci2B:
16.9		 4tzcB-4ci2B:
21.88
4tzcD-4ci2B:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hln STARCH SYNTHASE I

(Hordeum vulgare) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 TYR A 516
THR A 518
HIS A 588
TRP A 380
 None
 1.43A 4tzcB-4hlnA:
undetectable
4tzcD-4hlnA:
undetectable		 4tzcB-4hlnA:
11.32
4tzcD-4hlnA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Proteus
mirabilis) 		PF02028
(BCCT) 		4 TRP A 142
HIS A 141
TRP A 324
TRP A 147
 None
None
NM2  A 601 (-3.8A)
None
 1.45A 4tzcB-4m8jA:
undetectable
4tzcD-4m8jA:
undetectable		 4tzcB-4m8jA:
11.60
4tzcD-4m8jA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 TYR A 269
THR A 271
HIS A 327
PHE A 345
 None
None
RUB  A 501 (-4.1A)
None
 1.00A 4tzcB-4mkvA:
undetectable
4tzcD-4mkvA:
undetectable		 4tzcB-4mkvA:
13.32
4tzcD-4mkvA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 THR A 176
HIS A 129
TRP A 133
PHE A  86
 None
 1.21A 4tzcB-4rd8A:
undetectable
4tzcD-4rd8A:
undetectable		 4tzcB-4rd8A:
16.30
4tzcD-4rd8A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 THR A 255
TRP A 331
HIS A  85
TRP A 338
 None
 1.46A 4tzcB-4zq8A:
undetectable
4tzcD-4zq8A:
undetectable		 4tzcB-4zq8A:
16.29
4tzcD-4zq8A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		4 TYR A 165
THR A 160
TRP A 111
PHE A  85
 None
 1.32A 4tzcB-5b4sA:
undetectable
4tzcD-5b4sA:
undetectable		 4tzcB-5b4sA:
17.52
4tzcD-5b4sA:
17.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 4 TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
 85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
 0.45A 4tzcB-5hxbZ:
9.6
4tzcD-5hxbZ:
9.8		 4tzcB-5hxbZ:
33.02
4tzcD-5hxbZ:
33.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5,
MITOCHONDRIAL,NADH
DEHYDROGENASE
[UBIQUINONE] 1 BETA
SUBCOMPLEX SUBUNIT
5, MITOCHONDRIAL
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00146
(NADHdh)
PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		4 THR M 365
HIS M 440
TRP M 358
PHE h  21
 None
 1.05A 4tzcB-5lc5M:
undetectable
4tzcD-5lc5M:
undetectable		 4tzcB-5lc5M:
12.27
4tzcD-5lc5M:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Streptomyces
platensis) 		PF13714
(PEP_mutase) 		4 TYR A 103
THR A  76
HIS A 111
PHE A 166
 None
 1.24A 4tzcB-5uncA:
undetectable
4tzcD-5uncA:
undetectable		 4tzcB-5uncA:
13.86
4tzcD-5uncA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wh8 PUTATIVE
CARBOHYDRATE-ACTIVE
ENZYME

(uncultured
organism) 		no annotation 4 THR A 254
HIS A 156
TRP A 176
PHE A 175
 None
 1.13A 4tzcB-5wh8A:
undetectable
4tzcD-5wh8A:
undetectable		 4tzcB-5wh8A:
26.04
4tzcD-5wh8A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 4 TYR A 217
THR A 216
HIS A 225
TRP A 279
 None
 1.46A 4tzcB-5wmmA:
undetectable
4tzcD-5wmmA:
undetectable		 4tzcB-5wmmA:
15.74
4tzcD-5wmmA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 TYR A 259
TRP A 257
HIS A 185
PHE A 532
 None
 1.13A 4tzcB-5ww1A:
undetectable
4tzcD-5ww1A:
undetectable		 4tzcB-5ww1A:
20.00
4tzcD-5ww1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 4 TYR A  62
THR A  76
HIS A  83
TRP A 551
 None
 1.49A 4tzcB-6dk2A:
undetectable
4tzcD-6dk2A:
undetectable		 4tzcB-6dk2A:
undetectable
4tzcD-6dk2A:
undetectable