SIMILAR PATTERNS OF AMINO ACIDS FOR 4TYJ_A_0LIA801_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 VAL A 588
LYS A 608
ILE A 637
ARG A 723
ILE A 740
 None
 0.99A 4tyjA-1lufA:
34.4		 4tyjA-1lufA:
41.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A 164
VAL A 172
ILE A 225
ILE A 548
 ADP  A 810 ( 4.3A)
ADP  A 810 (-4.1A)
None
None
 0.45A 4tyjA-1q8yA:
21.0		 4tyjA-1q8yA:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 624
ILE A 674
ILE A 827
 None
 0.35A 4tyjA-1rjbA:
33.4		 4tyjA-1rjbA:
43.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 595
VAL A 603
ILE A 653
ARG A 791
ILE A 808
 STI  A   3 ( 3.8A)
STI  A   3 ( 4.6A)
None
None
None
 0.60A 4tyjA-1t46A:
35.7		 4tyjA-1t46A:
48.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 344
VAL A 352
LYS A 369
ILE A 398
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
 0.54A 4tyjA-1u59A:
30.9		 4tyjA-1u59A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 344
VAL A 352
LYS A 369
ILE A 398
ILE A 477
 STU  A 100 (-3.8A)
STU  A 100 (-4.8A)
STU  A 100 ( 4.7A)
None
None
 0.51A 4tyjA-1u59A:
30.9		 4tyjA-1u59A:
35.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  55
VAL A  63
ILE A 107
ILE A 189
 None
 0.51A 4tyjA-2hw6A:
20.7		 4tyjA-2hw6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  55
VAL A  63
LYS A  78
ILE A 107
 None
 0.57A 4tyjA-2hw6A:
20.7		 4tyjA-2hw6A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 348
VAL A 356
LYS A 371
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
None
 0.28A 4tyjA-2i0eA:
15.1		 4tyjA-2i0eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 348
VAL A 356
LYS A 371
ILE A 482
 PDS  A 901 (-3.9A)
PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
None
 0.70A 4tyjA-2i0eA:
15.1		 4tyjA-2i0eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 VAL A 356
LYS A 371
ARG A 465
ILE A 482
 PDS  A 901 (-4.2A)
PDS  A 901 ( 4.5A)
TPO  A 500 ( 2.9A)
None
 0.68A 4tyjA-2i0eA:
15.1		 4tyjA-2i0eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 VAL A 436
LYS A 454
ILE A 483
ARG A 545
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.4A)
None
None
 0.72A 4tyjA-2j0jA:
33.1		 4tyjA-2j0jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  29
VAL A  37
LYS A  52
ILE A  81
ILE A 163
 QPP  A1314 (-3.7A)
QPP  A1314 ( 4.6A)
None
None
None
 0.69A 4tyjA-2jc6A:
20.6		 4tyjA-2jc6A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 LEU A 344
VAL A 352
ILE A 398
ILE A 477
 ANP  A 615 (-4.4A)
ANP  A 615 (-4.5A)
None
None
 0.45A 4tyjA-2ozoA:
28.2		 4tyjA-2ozoA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU X  70
VAL X  78
LYS X  93
ILE X 117
 F10  X 401 (-3.9A)
None
F10  X 401 (-4.3A)
None
 0.56A 4tyjA-2p3gX:
17.8		 4tyjA-2p3gX:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 LEU A  25
VAL A  33
LYS A  48
ILE A  86
 ATP  A 381 ( 4.3A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
 0.70A 4tyjA-2phkA:
22.6		 4tyjA-2phkA:
22.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
VAL A 495
ILE A 547
ILE A 642
 None
 0.42A 4tyjA-2psqA:
36.6		 4tyjA-2psqA:
63.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU C  55
VAL C  63
LYS C  78
ILE C 192
 ANP  C   2 ( 4.4A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
 0.64A 4tyjA-2wtkC:
22.7		 4tyjA-2wtkC:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  34
LYS A  49
ARG A 139
ILE A  78
 J60  A1294 ( 4.9A)
None
TPO  A 174 ( 2.9A)
None
 0.73A 4tyjA-2xikA:
19.4		 4tyjA-2xikA:
26.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A  19
VAL A  27
LYS A  42
ILE A  76
 AMP  A1302 (-3.7A)
AMP  A1302 (-4.2A)
AMP  A1302 (-2.8A)
None
 0.62A 4tyjA-2yabA:
22.6		 4tyjA-2yabA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  97
VAL A 105
LYS A 123
ILE A 155
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
 0.28A 4tyjA-3a62A:
22.2		 4tyjA-3a62A:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  97
VAL A 105
LYS A 123
ILE A 155
 STU  A 400 (-3.8A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
 0.66A 4tyjA-3a62A:
22.2		 4tyjA-3a62A:
26.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 487
VAL A 495
ILE A 547
ILE A 642
 M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
 0.44A 4tyjA-3b2tA:
29.6		 4tyjA-3b2tA:
74.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 484
VAL A 492
ILE A 544
ILE A 639
 C4F  A   1 ( 3.9A)
None
None
None
 0.59A 4tyjA-3c4fA:
36.1		 4tyjA-3c4fA:
72.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 158
ILE A 203
ARG A 267
ILE A 292
 VIN  A6331 (-4.7A)
None
None
None
 0.53A 4tyjA-3dtcA:
18.0		 4tyjA-3dtcA:
35.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 158
LYS A 171
ILE A 203
ILE A 292
 VIN  A6331 (-4.7A)
None
None
None
 0.65A 4tyjA-3dtcA:
18.0		 4tyjA-3dtcA:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A  29
VAL A  37
ILE A  83
ILE A 165
 None
 0.69A 4tyjA-3dxnA:
22.8		 4tyjA-3dxnA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
LYS A  38
ILE A  62
 DRK  A 384 (-3.8A)
None
None
None
 0.63A 4tyjA-3eb0A:
21.2		 4tyjA-3eb0A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbz KINASE, CMGC CDK

(Giardia
intestinalis) 		PF00069
(Pkinase) 		4 LEU A  21
VAL A  29
ARG A 135
ILE A 157
 None
 0.70A 4tyjA-3gbzA:
21.8		 4tyjA-3gbzA:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  82
VAL A  90
ILE A 136
ILE A 218
 J60  A 540 (-3.8A)
None
None
None
 0.40A 4tyjA-3hztA:
19.2		 4tyjA-3hztA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  82
VAL A  90
LYS A 105
ILE A 136
 J60  A 540 (-3.8A)
None
GOL  A   1 (-2.7A)
None
 0.53A 4tyjA-3hztA:
19.2		 4tyjA-3hztA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		5 LEU A 226
VAL A 234
ILE A 285
ARG A 346
ILE A 366
 None
 1.05A 4tyjA-3i6uA:
21.1		 4tyjA-3i6uA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		4 VAL A  67
LYS A  82
ILE A 112
ILE A 191
 None
 0.53A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  82
VAL A  90
ILE A 135
ILE A 217
 ANP  A 610 ( 4.5A)
ANP  A 610 (-3.9A)
None
None
 0.35A 4tyjA-3igoA:
20.0		 4tyjA-3igoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A 141
VAL A 149
ILE A 193
ILE A 279
 ANP  A   1 (-3.9A)
ANP  A   1 (-4.9A)
None
None
 0.60A 4tyjA-3is5A:
18.1		 4tyjA-3is5A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A  40
VAL A  48
ILE A  94
ILE A 176
 DXR  A 299 ( 4.3A)
DXR  A 299 (-4.3A)
None
None
 0.60A 4tyjA-3ma6A:
21.0		 4tyjA-3ma6A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  63
VAL A  71
ILE A 127
ILE A 209
 ANP  A1634 ( 4.3A)
ANP  A1634 (-4.1A)
None
None
 0.43A 4tyjA-3q5iA:
20.2		 4tyjA-3q5iA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  57
VAL A  65
ILE A 111
ILE A 193
 BK5  A 701 ( 4.2A)
BK5  A 701 (-4.2A)
None
None
 0.32A 4tyjA-3sxfA:
21.4		 4tyjA-3sxfA:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 484
VAL A 492
LYS A 514
ILE A 544
ILE A 639
 07J  A   1 ( 4.3A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
None
None
 0.61A 4tyjA-3tt0A:
36.4		 4tyjA-3tt0A:
64.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 544
VAL A 552
ILE A 600
ARG A 678
ILE A 695
 0F4  A 902 ( 4.2A)
None
0F4  A 902 (-4.1A)
None
0F4  A 902 (-4.6A)
 0.66A 4tyjA-3v5qA:
27.4		 4tyjA-3v5qA:
37.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 848
LYS A 868
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
 0.31A 4tyjA-3vidA:
29.5		 4tyjA-3vidA:
48.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 848
LYS A 868
ILE A1044
 4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.5A)
None
None
 0.67A 4tyjA-3vidA:
29.5		 4tyjA-3vidA:
48.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 139
VAL A 147
ILE A 193
ILE A 272
 N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
None
None
 0.35A 4tyjA-3w18A:
23.0		 4tyjA-3w18A:
27.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 840
VAL A 848
LYS A 868
ARG A1027
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
None
 0.84A 4tyjA-3wzdA:
29.7		 4tyjA-3wzdA:
51.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 840
VAL A 848
LYS A 868
ILE A1044
 LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
None
 0.65A 4tyjA-3wzdA:
29.7		 4tyjA-3wzdA:
51.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 560
VAL A 568
ILE A 616
ILE A 708
 LTI  A1839 ( 4.2A)
None
None
None
 0.65A 4tyjA-4at3A:
30.8		 4tyjA-4at3A:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 560
VAL A 568
LYS A 588
ILE A 616
 LTI  A1839 ( 4.2A)
None
None
None
 0.61A 4tyjA-4at3A:
30.8		 4tyjA-4at3A:
38.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 VAL A  30
ILE A  76
ARG A 138
ILE A 155
 None
None
TPO  A 172 ( 2.4A)
None
 0.70A 4tyjA-4cfhA:
23.5		 4tyjA-4cfhA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 616
VAL A 624
LYS A 655
ILE A 684
ARG A 765
ILE A 782
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.9A)
DI1  A1000 ( 4.5A)
None
DI1  A1000 (-4.5A)
 1.02A 4tyjA-4ckrA:
30.6		 4tyjA-4ckrA:
36.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 663
VAL A 671
ARG A 781
ILE A 798
 AGS  A1985 (-4.2A)
AGS  A1985 (-4.6A)
TPO  A 816 ( 3.0A)
None
 0.73A 4tyjA-4crsA:
21.3		 4tyjA-4crsA:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 LEU A  16
VAL A  24
ILE A  70
ILE A 149
 ANP  A 300 (-4.7A)
ANP  A 300 ( 4.7A)
None
None
 0.54A 4tyjA-4eqmA:
22.4		 4tyjA-4eqmA:
24.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 515
VAL A 523
LYS A 543
ARG A 648
 None
 0.72A 4tyjA-4f0iA:
31.6		 4tyjA-4f0iA:
39.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 523
LYS A 543
ILE A 571
ARG A 648
ILE A 665
 None
 0.84A 4tyjA-4f0iA:
31.6		 4tyjA-4f0iA:
39.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 377
VAL A 385
ILE A 432
ARG A 493
ILE A 510
 ANP  A 701 ( 4.6A)
ANP  A 701 (-4.1A)
None
None
None
 0.73A 4tyjA-4fl3A:
23.6		 4tyjA-4fl3A:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1122
VAL A1130
ILE A1179
ILE A1268
 0UV  A1501 (-3.8A)
0UV  A1501 (-4.5A)
None
None
 0.55A 4tyjA-4fodA:
30.9		 4tyjA-4fodA:
37.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 598
VAL A 606
LYS A 621
ILE A 650
 924  A1101 ( 4.1A)
924  A1101 ( 4.8A)
None
None
 0.49A 4tyjA-4g34A:
21.6		 4tyjA-4g34A:
24.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 855
VAL A 863
LYS A 882
ILE A 910
ILE A 992
 IZA  A2001 (-3.7A)
None
IZA  A2001 ( 4.7A)
None
None
 0.60A 4tyjA-4gl9A:
22.1		 4tyjA-4gl9A:
33.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 828
VAL A 836
LYS A 855
ILE A 883
ILE A 965
 19S  A1201 (-3.9A)
19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
None
None
 0.56A 4tyjA-4hviA:
30.0		 4tyjA-4hviA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		4 LEU A 132
VAL A 140
ARG A 251
ILE A 268
 None
 0.56A 4tyjA-4hzsA:
27.6		 4tyjA-4hzsA:
38.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Mus musculus) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  23
LYS A  38
ILE A  67
 SU6  A 701 (-3.6A)
None
None
None
 0.45A 4tyjA-4jlcA:
18.4		 4tyjA-4jlcA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  18
VAL A  26
ILE A  72
ILE A 152
 631  A 301 (-3.4A)
631  A 301 (-4.6A)
None
None
 0.43A 4tyjA-4jxfA:
19.3		 4tyjA-4jxfA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  26
LYS A  41
ILE A  72
ILE A 152
 631  A 301 (-4.6A)
631  A 301 (-2.7A)
None
None
 0.58A 4tyjA-4jxfA:
19.3		 4tyjA-4jxfA:
26.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 478
VAL A 486
ILE A 538
ILE A 633
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
None
None
 0.40A 4tyjA-4k33A:
30.1		 4tyjA-4k33A:
74.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 478
VAL A 486
LYS A 508
ILE A 538
 ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
None
 0.57A 4tyjA-4k33A:
30.1		 4tyjA-4k33A:
74.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A  50
LYS A  63
ILE A  89
ILE A 173
 1UL  A 501 ( 4.9A)
None
None
None
 0.64A 4tyjA-4l52A:
20.5		 4tyjA-4l52A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  78
VAL A  86
ILE A 129
ILE A 211
 STU  A 601 ( 4.0A)
STU  A 601 (-4.8A)
None
None
 0.63A 4tyjA-4mvfA:
19.6		 4tyjA-4mvfA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ng3 5-CARBOXYVANILLATE
DECARBOXYLASE

(Sphingomonas
paucimobilis) 		PF04909
(Amidohydro_2) 		5 LEU A 137
VAL A 131
ILE A 172
ARG A 216
ILE A 222
 None
 1.01A 4tyjA-4ng3A:
undetectable		 4tyjA-4ng3A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 903
VAL A 911
LYS A 930
ILE A 959
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
 0.67A 4tyjA-4oliA:
28.0		 4tyjA-4oliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 903
VAL A 911
LYS A 930
ILE A 959
ILE A1039
 2TT  A1202 (-3.5A)
2TT  A1202 (-4.5A)
None
None
None
 0.61A 4tyjA-4oliA:
28.0		 4tyjA-4oliA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  24
VAL A  32
LYS A  47
ILE A  78
 STU  A 601 (-3.7A)
STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
None
 0.50A 4tyjA-4rewA:
23.2		 4tyjA-4rewA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  76
VAL A  84
ILE A 130
ILE A 213
 None
 0.42A 4tyjA-4rgjA:
20.4		 4tyjA-4rgjA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgj CALCIUM-DEPENDENT
PROTEIN KINASE 4

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  76
VAL A  84
ILE A 213
ILE A 199
 None
 0.65A 4tyjA-4rgjA:
20.4		 4tyjA-4rgjA:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 624
ILE A 674
ILE A 827
 P30  A1001 (-3.8A)
None
None
P30  A1001 ( 4.8A)
 0.25A 4tyjA-4rt7A:
29.7		 4tyjA-4rt7A:
38.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA

(Bacillus
subtilis) 		PF10747
(SirA) 		4 LEU A  28
ILE A  56
ARG A 120
ILE A 101
 None
 0.71A 4tyjA-4tpsA:
undetectable		 4tyjA-4tpsA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 193
LYS A 216
ILE A 247
ARG A 313
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
 1.01A 4tyjA-4wboA:
22.6		 4tyjA-4wboA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 193
VAL A 201
LYS A 216
ILE A 247
ILE A 330
 ANW  A 601 ( 4.0A)
None
None
None
None
 0.78A 4tyjA-4wboA:
22.6		 4tyjA-4wboA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
VAL A  60
LYS A  74
ILE A 103
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
 0.59A 4tyjA-4wsqA:
22.5		 4tyjA-4wsqA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
VAL A  60
LYS A  74
ILE A 103
 KSA  A 405 ( 4.0A)
KSA  A 405 ( 4.9A)
None
None
 0.68A 4tyjA-4wsqA:
22.5		 4tyjA-4wsqA:
25.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 473
VAL A 481
ILE A 533
ARG A 611
ILE A 628
 40M  A1002 ( 4.6A)
40M  A1002 ( 4.5A)
None
None
None
 0.72A 4tyjA-4xcuA:
36.2		 4tyjA-4xcuA:
94.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 616
VAL A 624
LYS A 644
ILE A 674
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.3A)
P30  A1001 (-4.7A)
 0.45A 4tyjA-4xufA:
34.0		 4tyjA-4xufA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 616
VAL A 624
LYS A 644
ILE A 827
 P30  A1001 (-4.0A)
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-4.7A)
 0.70A 4tyjA-4xufA:
34.0		 4tyjA-4xufA:
47.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 193
VAL A 201
LYS A 216
ILE A 328
ILE A 318
 AN2  A 601 ( 4.2A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
 1.41A 4tyjA-4yhjA:
20.4		 4tyjA-4yhjA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  34
VAL A  42
ILE A  88
ILE A 170
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
None
None
 0.49A 4tyjA-4ysjA:
22.7		 4tyjA-4ysjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  34
VAL A  42
LYS A  57
ILE A  88
 ADP  A 506 ( 3.8A)
ADP  A 506 (-4.3A)
ADP  A 506 (-2.4A)
None
 0.72A 4tyjA-4ysjA:
22.7		 4tyjA-4ysjA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A  30
ILE A  75
ARG A 137
ILE A 163
 51W  A 401 ( 4.3A)
None
TPO  A 180 ( 2.9A)
None
 0.72A 4tyjA-5ci7A:
23.7		 4tyjA-5ci7A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		5 LEU A  99
VAL A 107
ILE A 153
ARG A 140
ILE A 232
 5U5  A 401 (-3.8A)
5U5  A 401 ( 4.3A)
None
TPO  A 248 ( 4.5A)
None
 1.06A 4tyjA-5eykA:
19.6		 4tyjA-5eykA:
25.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 903
VAL A 911
ILE A 959
ILE A1039
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
None
 0.53A 4tyjA-5f1zA:
28.7		 4tyjA-5f1zA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 903
VAL A 911
LYS A 930
ILE A 959
 5U3  A1200 (-3.8A)
5U3  A1200 ( 4.4A)
None
None
 0.67A 4tyjA-5f1zA:
28.7		 4tyjA-5f1zA:
36.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 599
VAL A 607
ILE A 657
ARG A 817
ILE A 834
 748  A1001 (-3.8A)
748  A1001 ( 4.7A)
748  A1001 ( 4.4A)
None
748  A1001 (-4.8A)
 0.44A 4tyjA-5grnA:
27.0		 4tyjA-5grnA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A  30
LYS A  45
ILE A  65
ILE A 149
 032  A 401 (-4.4A)
032  A 401 (-4.4A)
None
None
 0.68A 4tyjA-5hesA:
7.1		 4tyjA-5hesA:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  57
VAL A  65
LYS A  79
ILE A 108
 IDV  A 401 (-3.8A)
IDV  A 401 (-4.6A)
IDV  A 401 ( 4.8A)
None
 0.55A 4tyjA-5i3oA:
22.5		 4tyjA-5i3oA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfa RESPONSE REGULATOR

(Streptococcus
pneumoniae) 		no annotation 4 VAL A 105
LYS A 103
ILE A  77
ILE A  50
 None
 0.71A 4tyjA-5vfaA:
undetectable		 4tyjA-5vfaA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 4 LEU A 686
VAL A 694
ILE A 737
ILE A 820
 9E1  A1001 (-3.7A)
9E1  A1001 ( 4.0A)
None
None
 0.54A 4tyjA-5vilA:
24.9		 4tyjA-5vilA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 4 LEU A  24
VAL A  32
ILE A  78
ILE A 162
 9WS  A 401 ( 4.2A)
9WS  A 401 ( 4.6A)
None
None
 0.43A 4tyjA-5w5jA:
24.6		 4tyjA-5w5jA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 4 LEU A 891
VAL A 899
LYS A 919
ILE A1026
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
 0.70A 4tyjA-5wnoA:
28.0		 4tyjA-5wnoA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 4 LEU A 891
VAL A 899
LYS A 919
ILE A1026
 ANP  A1201 (-4.1A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.8A)
None
 0.71A 4tyjA-5wnoA:
28.0		 4tyjA-5wnoA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 4 LEU A  22
VAL A  30
ILE A  76
ILE A 155
 EDJ  A 301 (-3.9A)
None
None
None
 0.72A 4tyjA-6bx6A:
19.2		 4tyjA-6bx6A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 LEU A 881
VAL A 889
ILE A 937
ILE A1019
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
None
None
 0.42A 4tyjA-6c7yA:
28.2		 4tyjA-6c7yA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 LEU A 881
VAL A 889
LYS A 908
ILE A 937
 ADP  A1201 ( 4.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
 0.61A 4tyjA-6c7yA:
28.2		 4tyjA-6c7yA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 4 LEU U  20
VAL U  28
LYS U  44
ILE U 143
 DB8  U 301 (-3.7A)
DB8  U 301 ( 4.8A)
DB8  U 301 ( 4.0A)
None
 0.62A 4tyjA-6fdyU:
21.7		 4tyjA-6fdyU:
undetectable