SIMILAR PATTERNS OF AMINO ACIDS FOR 4TYJ_A_0LIA801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 ALA A 220
GLU A 236
MET A 240
HIS A 312
LEU A 321
 None
 0.48A 4tyjA-1k9aA:
31.8		 4tyjA-1k9aA:
30.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 606
HIS A 722
LEU A 731
ALA A 741
ASP A 742
 None
 0.66A 4tyjA-1lufA:
34.4		 4tyjA-1lufA:
41.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
GLU A 305
MET A 309
ILE A 312
HIS A 380
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.64A 4tyjA-1opkA:
30.8		 4tyjA-1opkA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ALA A 230
GLU A 245
HIS A 331
LEU A 340
ALA A 350
 PY1  A 700 (-3.5A)
PY1  A 700 ( 4.9A)
None
PY1  A 700 (-4.4A)
PY1  A 700 ( 4.2A)
 0.50A 4tyjA-1py5A:
25.8		 4tyjA-1py5A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 ALA A 185
GLU A 202
HIS A 292
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-3.3A)
None
None
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 1.14A 4tyjA-1q8yA:
21.0		 4tyjA-1q8yA:
22.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
GLU A 640
CYH A 788
HIS A 790
LEU A 799
ASP A 810
PHE A 811
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-2.8A)
STI  A   3 (-4.5A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
STI  A   3 (-3.6A)
 0.79A 4tyjA-1t46A:
35.7		 4tyjA-1t46A:
48.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 367
GLU A 386
MET A 390
ALA A 417
HIS A 459
LEU A 468
 STU  A 100 (-3.2A)
None
None
STU  A 100 (-3.7A)
None
STU  A 100 (-4.5A)
 0.65A 4tyjA-1u59A:
30.9		 4tyjA-1u59A:
35.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
GLU X  54
MET X  58
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.56A 4tyjA-2dq7X:
31.2		 4tyjA-2dq7X:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA X  37
MET X  58
HIS X 128
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.45A 4tyjA-2dq7X:
31.2		 4tyjA-2dq7X:
35.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 184
GLU A 201
ILE A 208
HIS A 281
LEU A 290
ALA A 319
 None
 0.76A 4tyjA-2eu9A:
21.9		 4tyjA-2eu9A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwm 2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
DEHYDROGENASE

(Escherichia
coli) 		PF13561
(adh_short_C2) 		6 ALA X  30
ILE X 126
VAL X   8
ALA X  24
LEU X 223
ALA X 226
 None
 1.25A 4tyjA-2fwmX:
undetectable		 4tyjA-2fwmX:
21.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 271
GLU A 288
MET A 292
HIS A 362
LEU A 371
ALA A 381
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.75A 4tyjA-2hk5A:
26.1		 4tyjA-2hk5A:
41.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
MET A 290
ILE A 293
HIS A 361
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.3A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.88A 4tyjA-2hz0A:
31.9		 4tyjA-2hz0A:
40.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 ALA A 452
GLU A 471
MET A 475
HIS A 544
LEU A 553
 4ST  A1687 (-3.3A)
4ST  A1687 ( 4.6A)
None
None
4ST  A1687 (-4.4A)
 0.53A 4tyjA-2j0jA:
33.1		 4tyjA-2j0jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
GLU A  51
HIS A 125
LEU A 134
ALA A 144
 None
 0.63A 4tyjA-2jgzA:
23.0		 4tyjA-2jgzA:
25.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 452
GLU A 471
MET A 475
HIS A 544
LEU A 553
 BII  A1687 (-3.5A)
None
None
None
BII  A1687 (-4.2A)
 0.67A 4tyjA-2jkmA:
32.8		 4tyjA-2jkmA:
37.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
GLU A 288
MET A 292
HIS A 362
LEU A 371
ALA A 381
ASP A 382
PHE A 383
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
 0.56A 4tyjA-2og8A:
26.8		 4tyjA-2og8A:
40.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 614
GLU A 633
MET A 637
CYH A 774
HIS A 776
LEU A 785
ASP A 796
 None
 0.77A 4tyjA-2ogvA:
33.1		 4tyjA-2ogvA:
45.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 853
ALA A 905
HIS A 962
LEU A 971
ALA A 981
ASP A 982
PHE A 983
 MR9  A 301 (-3.5A)
MR9  A 301 (-3.6A)
MR9  A 301 (-4.5A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
MR9  A 301 (-4.4A)
 0.47A 4tyjA-2p4iA:
17.4		 4tyjA-2p4iA:
43.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 515
GLU A 534
MET A 538
ILE A 541
VAL A 564
ALA A 567
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 None
 0.56A 4tyjA-2psqA:
36.6		 4tyjA-2psqA:
63.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 705
GLU A 724
MET A 728
HIS A 798
LEU A 807
ASP A 818
 None
 1.23A 4tyjA-2r2pA:
28.2		 4tyjA-2r2pA:
31.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 273
MET A 294
HIS A 365
LEU A 374
ALA A 384
 None
 0.65A 4tyjA-2zv7A:
31.4		 4tyjA-2zv7A:
40.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 515
GLU A 534
MET A 538
ILE A 541
VAL A 564
CYH A 622
HIS A 624
 M33  A1996 (-3.3A)
None
None
None
None
None
None
 0.94A 4tyjA-3b2tA:
29.6		 4tyjA-3b2tA:
74.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 515
MET A 538
ILE A 541
VAL A 564
ALA A 567
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
None
None
None
M33  A1996 (-3.8A)
None
None
M33  A1996 (-4.5A)
None
 0.58A 4tyjA-3b2tA:
29.6		 4tyjA-3b2tA:
74.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1108
GLU A1127
MET A1131
HIS A1202
ALA A1221
ASP A1222
 CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.89A 4tyjA-3c1xA:
26.7		 4tyjA-3c1xA:
31.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 512
GLU A 531
MET A 535
ALA A 564
CYH A 619
HIS A 621
LEU A 630
ALA A 640
PHE A 489
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
C4F  A   1 (-3.7A)
 0.73A 4tyjA-3c4fA:
36.1		 4tyjA-3c4fA:
72.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
MET A 535
ILE A 538
VAL A 561
ALA A 564
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 ( 4.8A)
C4F  A   1 (-3.5A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.67A 4tyjA-3c4fA:
36.1		 4tyjA-3c4fA:
72.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 220
GLU A 236
MET A 240
HIS A 312
LEU A 321
 None
 0.48A 4tyjA-3d7uA:
26.9		 4tyjA-3d7uA:
40.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 663
GLU A 682
MET A 686
HIS A 756
LEU A 765
ASP A 776
PHE A 777
 IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
IHZ  A1001 (-4.7A)
 0.68A 4tyjA-3dkoA:
32.8		 4tyjA-3dkoA:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 859
GLU A 878
ILE A 885
VAL A 909
CYH A1018
HIS A1020
LEU A1029
ASP A1040
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
None
 0.88A 4tyjA-3hngA:
34.8		 4tyjA-3hngA:
46.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 859
GLU A 878
VAL A 909
CYH A1018
HIS A1020
LEU A1029
ASP A1040
PHE A1041
 8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.1A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
None
8ST  A2001 ( 3.7A)
 0.92A 4tyjA-3hngA:
34.8		 4tyjA-3hngA:
46.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 881
VAL A 907
ALA A 859
CYH A1018
HIS A1020
ASP A1040
 None
8ST  A2001 (-4.5A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 1.40A 4tyjA-3hngA:
34.8		 4tyjA-3hngA:
46.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ILE A 885
VAL A 907
ALA A 859
CYH A1018
HIS A1020
ASP A1040
 None
8ST  A2001 (-4.5A)
8ST  A2001 ( 3.8A)
8ST  A2001 ( 4.7A)
8ST  A2001 ( 4.8A)
None
 1.47A 4tyjA-3hngA:
34.8		 4tyjA-3hngA:
46.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 ALA A  80
MET A 104
ALA A 132
HIS A 173
LEU A 182
ALA A 192
ASP A 193
 None
 0.95A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  80
MET A 104
CYH A 166
HIS A 173
LEU A 182
ALA A 192
 None
 1.38A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 GLU A 100
MET A 104
ALA A 132
HIS A 173
LEU A 182
ALA A 192
ASP A 193
 None
 1.18A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 GLU A 100
MET A 104
CYH A 166
HIS A 173
LEU A 182
ALA A 192
 None
 1.31A 4tyjA-3iecA:
22.8		 4tyjA-3iecA:
29.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		5 ALA A 665
GLU A 684
MET A 688
HIS A 758
LEU A 767
 None
 0.56A 4tyjA-3kulA:
32.8		 4tyjA-3kulA:
34.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  46
GLU A  66
HIS A 147
LEU A 156
ALA A 166
 None
 0.69A 4tyjA-3mi9A:
22.3		 4tyjA-3mi9A:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n90 THYLAKOID LUMENAL 15
KDA PROTEIN 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00805
(Pentapeptide) 		5 ALA A 146
LEU A 148
ALA A 151
ASP A 152
PHE A 153
 None
 0.65A 4tyjA-3n90A:
undetectable		 4tyjA-3n90A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		5 ALA A  55
GLU A  75
ALA A 112
HIS A 152
LEU A 161
 GOL  A 434 ( 4.1A)
GOL  A 433 ( 4.8A)
GOL  A 434 (-3.9A)
None
GOL  A 434 (-4.2A)
 0.57A 4tyjA-3n9xA:
20.4		 4tyjA-3n9xA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ALA A  57
GLU A  77
ALA A 114
HIS A 154
LEU A 163
ASP A 174
 ANP  A 430 (-3.5A)
ANP  A 430 ( 4.4A)
ANP  A 430 (-3.9A)
None
ANP  A 430 (-4.4A)
ANP  A 430 (-2.8A)
 1.04A 4tyjA-3nieA:
21.0		 4tyjA-3nieA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 ALA A  57
ILE A  80
ALA A 114
HIS A 154
LEU A 163
ASP A 174
 ANP  A 430 (-3.5A)
None
ANP  A 430 (-3.9A)
None
ANP  A 430 (-4.4A)
ANP  A 430 (-2.8A)
 1.24A 4tyjA-3nieA:
21.0		 4tyjA-3nieA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		6 ALA A  49
GLU A  69
HIS A 142
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-3.5A)
None
None
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 1.16A 4tyjA-3nizA:
23.2		 4tyjA-3nizA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 109
GLU A 130
MET A 134
ALA A 162
HIS A 203
LEU A 212
ASP A 223
 JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
JOZ  A 361 (-3.8A)
None
None
SO4  A   5 ( 4.5A)
 0.95A 4tyjA-3nuuA:
23.6		 4tyjA-3nuuA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ALA A  38
GLU A  58
HIS A 132
LEU A 141
ALA A 151
 None
 0.70A 4tyjA-3oz6A:
20.7		 4tyjA-3oz6A:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		5 ALA A 576
GLU A 596
MET A 600
HIS A 674
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.3A)
 0.53A 4tyjA-3ppzA:
28.5		 4tyjA-3ppzA:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
MET A 535
ILE A 538
VAL A 561
ALA A 564
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 07J  A   1 (-3.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
None
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.74A 4tyjA-3tt0A:
36.4		 4tyjA-3tt0A:
64.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 570
GLU A 588
HIS A 677
LEU A 686
ASP A 697
PHE A 698
 0F4  A 902 (-3.2A)
0F4  A 902 (-3.6A)
0F4  A 902 (-4.1A)
0F4  A 902 (-4.5A)
None
0F4  A 902 (-4.1A)
 0.88A 4tyjA-3v5qA:
27.4		 4tyjA-3v5qA:
37.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
ILE A 892
VAL A 916
CYH A1024
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.73A 4tyjA-3vidA:
29.5		 4tyjA-3vidA:
48.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
ILE A 892
VAL A 916
HIS A1026
LEU A1035
ASP A1046
 4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.70A 4tyjA-3vidA:
29.5		 4tyjA-3vidA:
48.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 160
ALA A 213
HIS A 254
LEU A 263
ALA A 273
 N13  A 501 ( 4.1A)
N13  A 501 (-3.7A)
None
N13  A 501 (-4.5A)
N13  A 501 ( 3.8A)
 0.60A 4tyjA-3w18A:
22.9		 4tyjA-3w18A:
27.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
ILE A 892
VAL A 916
CYH A1024
HIS A1026
LEU A1035
 LEV  A1201 (-3.5A)
LEV  A1201 (-3.7A)
None
LEV  A1201 ( 4.6A)
DTT  A1202 (-2.0A)
None
LEV  A1201 (-4.8A)
 0.59A 4tyjA-3wzdA:
29.7		 4tyjA-3wzdA:
51.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 866
GLU A 885
HIS A1026
LEU A1035
ASP A1046
PHE A1047
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.5A)
None
B49  A2000 (-4.0A)
 0.96A 4tyjA-4agdA:
35.3		 4tyjA-4agdA:
47.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
ILE A 892
VAL A 916
CYH A1024
LEU A1035
ASP A1046
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
B49  A2000 (-4.5A)
None
 0.86A 4tyjA-4agdA:
35.3		 4tyjA-4agdA:
47.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 866
GLU A 885
ILE A 892
VAL A 916
HIS A1026
LEU A1035
ASP A1046
 B49  A2000 (-3.5A)
None
None
B49  A2000 (-4.8A)
None
B49  A2000 (-4.5A)
None
 0.81A 4tyjA-4agdA:
35.3		 4tyjA-4agdA:
47.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  31
GLU A  51
CYH A 122
HIS A 124
LEU A 133
 D15  A 500 (-3.4A)
None
None
None
D15  A 500 (-4.5A)
 0.65A 4tyjA-4aguA:
23.6		 4tyjA-4aguA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 ALA A 104
GLU A 125
HIS A 199
LEU A 208
ALA A 218
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.0A)
None
EDO  A1420 ( 4.8A)
None
 0.63A 4tyjA-4aw2A:
19.4		 4tyjA-4aw2A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A  63
GLU A  81
HIS A 155
LEU A 164
ALA A 174
 XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.65A 4tyjA-4bc6A:
21.4		 4tyjA-4bc6A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		5 ALA A 267
GLU A 288
ALA A 321
HIS A 362
LEU A 371
 None
 0.70A 4tyjA-4c0tA:
22.6		 4tyjA-4c0tA:
15.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 653
GLU A 672
MET A 676
HIS A 764
LEU A 773
ALA A 783
ASP A 784
PHE A 785
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
DI1  A1000 (-4.5A)
 0.80A 4tyjA-4ckrA:
30.6		 4tyjA-4ckrA:
36.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 400
GLU A 420
MET A 424
ALA A 451
HIS A 492
LEU A 501
 0SB  A 701 (-3.3A)
None
None
0SB  A 701 (-4.0A)
None
0SB  A 701 (-4.4A)
 0.78A 4tyjA-4f4pA:
30.2		 4tyjA-4f4pA:
37.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 853
GLU A 871
CYH A 945
HIS A 947
LEU A 956
ALA A 966
 19S  A1201 (-3.3A)
None
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.58A 4tyjA-4hviA:
30.0		 4tyjA-4hviA:
33.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 506
GLU A 525
MET A 529
ILE A 532
VAL A 555
ALA A 558
CYH A 613
LEU A 624
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
ACP  A 801 (-4.4A)
 0.85A 4tyjA-4k33A:
30.1		 4tyjA-4k33A:
74.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 ALA A 506
GLU A 525
MET A 529
ILE A 532
VAL A 555
ALA A 558
HIS A 615
LEU A 624
ALA A 634
 ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
ACP  A 801 (-4.4A)
None
 0.56A 4tyjA-4k33A:
30.1		 4tyjA-4k33A:
74.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 506
MET A 529
ILE A 532
VAL A 555
ALA A 558
HIS A 615
ALA A 634
ASP A 635
 ACP  A 801 (-3.3A)
None
None
ACP  A 801 (-4.7A)
ACP  A 801 (-3.7A)
None
None
MG  A 802 ( 3.0A)
 0.96A 4tyjA-4k33A:
30.1		 4tyjA-4k33A:
74.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A  61
GLU A  77
ALA A 107
HIS A 154
LEU A 163
 1UL  A 501 (-3.1A)
None
1UL  A 501 (-3.6A)
None
1UL  A 501 (-4.3A)
 0.57A 4tyjA-4l52A:
20.5		 4tyjA-4l52A:
28.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 ALA A 293
MET A 314
HIS A 384
LEU A 393
ALA A 403
 VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.58A 4tyjA-4lggA:
29.5		 4tyjA-4lggA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA B  51
GLU B  70
HIS B 142
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.99A 4tyjA-4o27B:
20.4		 4tyjA-4o27B:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		6 ALA B 390
GLU B 404
VAL B 434
CYH B 479
LEU B 492
ALA B 502
 ACP  B 801 (-3.2A)
None
ACP  B 801 (-4.8A)
None
ACP  B 801 (-4.5A)
None
 1.25A 4tyjA-4oavB:
17.7		 4tyjA-4oavB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA B 390
VAL B 434
HIS B 483
LEU B 492
ALA B 502
 ACP  B 801 (-3.2A)
ACP  B 801 (-4.8A)
None
ACP  B 801 (-4.5A)
None
 0.65A 4tyjA-4oavB:
17.7		 4tyjA-4oavB:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 4.3A)
P30  A1001 (-4.6A)
None
P30  A1001 (-3.9A)
 0.76A 4tyjA-4rt7A:
29.7		 4tyjA-4rt7A:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tpt LIM DOMAIN KINASE 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 HIS A 449
LEU A 458
ALA A 468
ASP A 469
PHE A 470
 35H  A 701 ( 4.4A)
None
35H  A 701 (-3.5A)
35H  A 701 (-4.7A)
35H  A 701 (-4.4A)
 0.46A 4tyjA-4tptA:
21.9		 4tyjA-4tptA:
30.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 ALA A  35
GLU A  52
MET A  56
HIS A 127
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 ( 4.8A)
None
None
 1.04A 4tyjA-4ueuA:
31.4		 4tyjA-4ueuA:
41.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 501
GLU A 520
MET A 524
ILE A 527
VAL A 550
ALA A 553
CYH A 608
HIS A 610
LEU A 619
ALA A 629
 40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.7A)
40M  A1002 (-3.7A)
None
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.69A 4tyjA-4xcuA:
36.2		 4tyjA-4xcuA:
94.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 6 ALA B 288
MET B 309
ILE B 312
HIS B 380
LEU B 389
ALA B 399
 1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.61A 4tyjA-4xeyB:
32.4		 4tyjA-4xeyB:
32.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 642
GLU A 661
HIS A 809
LEU A 818
ASP A 829
PHE A 830
 P30  A1001 (-3.5A)
P30  A1001 (-3.1A)
P30  A1001 (-4.4A)
P30  A1001 (-4.3A)
None
P30  A1001 ( 4.1A)
 0.65A 4tyjA-4xufA:
34.0		 4tyjA-4xufA:
47.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 512
GLU A 531
MET A 535
ILE A 538
VAL A 561
ALA A 564
CYH A 619
HIS A 621
LEU A 630
ALA A 640
 38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.3A)
38O  A1769 (-3.9A)
None
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.76A 4tyjA-5a46A:
36.2		 4tyjA-5a46A:
64.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  83
GLU A 103
ALA A 135
HIS A 176
LEU A 185
ALA A 195
 5RC  A4000 (-3.6A)
None
5RC  A4000 (-3.7A)
None
None
5RC  A4000 ( 3.9A)
 1.06A 4tyjA-5es1A:
23.2		 4tyjA-5es1A:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		6 ALA A  83
GLU A 103
CYH A 169
HIS A 176
LEU A 185
ALA A 195
 5RC  A4000 (-3.6A)
None
None
None
None
5RC  A4000 ( 3.9A)
 1.39A 4tyjA-5es1A:
23.2		 4tyjA-5es1A:
24.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 756
VAL A 804
ALA A 807
HIS A 872
LEU A 881
 PP1  A2012 (-3.2A)
PP1  A2012 (-4.5A)
PP1  A2012 ( 3.5A)
None
PP1  A2012 (-4.6A)
 0.50A 4tyjA-5fm2A:
34.6		 4tyjA-5fm2A:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
GLU A 644
CYH A 814
HIS A 816
LEU A 825
ASP A 836
PHE A 837
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
748  A1001 (-3.7A)
 0.77A 4tyjA-5grnA:
27.0		 4tyjA-5grnA:
44.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 625
GLU A 644
MET A 648
CYH A 814
HIS A 816
LEU A 825
ASP A 836
 748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.4A)
748  A1001 (-3.8A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.54A 4tyjA-5grnA:
27.0		 4tyjA-5grnA:
44.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		5 ALA A  41
GLU A  61
HIS A 134
LEU A 143
ALA A 156
 ADP  A 301 (-3.5A)
None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
 0.58A 4tyjA-5hu3A:
23.5		 4tyjA-5hu3A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  50
GLU A  66
ALA A 100
HIS A 149
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-3.7A)
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 1.11A 4tyjA-5idnA:
21.4		 4tyjA-5idnA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izk SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Homo sapiens) 		PF00009
(GTP_EFTU) 		6 ALA A 412
ILE A 136
VAL A 319
LEU A 329
ALA A 445
PHE A 335
 None
 1.34A 4tyjA-5izkA:
undetectable		 4tyjA-5izkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  43
GLU A  61
MET A  65
HIS A 134
LEU A 143
ALA A 153
 6G2  A 901 (-3.2A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.69A 4tyjA-5j5tA:
21.8		 4tyjA-5j5tA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 297
GLU A 315
MET A 319
HIS A 387
LEU A 396
ASP A 407
 IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
None
 1.04A 4tyjA-5kbrA:
22.1		 4tyjA-5kbrA:
26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 663
MET A 686
HIS A 756
LEU A 765
ASP A 776
 6P6  A1001 (-3.3A)
6P6  A1001 ( 4.2A)
DIO  A1002 (-4.1A)
6P6  A1001 (-4.5A)
None
 0.63A 4tyjA-5l6oA:
32.0		 4tyjA-5l6oA:
34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		6 ALA A 219
ILE A 228
VAL A 221
LEU A  14
ASP A 194
PHE A 191
 None
 1.29A 4tyjA-5te1A:
undetectable		 4tyjA-5te1A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 119
GLU A 140
MET A 144
HIS A 212
LEU A 221
ALA A 231
 None
 1.10A 4tyjA-5u7qA:
19.6		 4tyjA-5u7qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 119
MET A 144
ILE A 143
HIS A 212
LEU A 221
ALA A 231
 None
 1.47A 4tyjA-5u7qA:
19.6		 4tyjA-5u7qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 MET A 144
ILE A 143
CYH A 236
LEU A 221
ALA A 231
ASP A 232
 None
 1.41A 4tyjA-5u7qA:
19.6		 4tyjA-5u7qA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 5 ALA A  49
GLU A  69
MET A  73
HIS A 141
LEU A 150
 VX6  A 402 (-3.2A)
VX6  A 402 (-4.4A)
None
None
VX6  A 402 (-4.4A)
 0.69A 4tyjA-5wnmA:
28.2		 4tyjA-5wnmA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 5 ALA A 754
GLU A 774
HIS A 857
LEU A 866
ALA A 876
 CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.61A 4tyjA-6b3eA:
22.6		 4tyjA-6b3eA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 ALA A  87
GLU A 107
MET A 111
ALA A 139
HIS A 180
LEU A 189
ALA A 199
 None
 0.86A 4tyjA-6c9dA:
21.9		 4tyjA-6c9dA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 ALA A  87
GLU A 107
MET A 111
CYH A 173
HIS A 180
LEU A 189
ALA A 199
 None
 1.40A 4tyjA-6c9dA:
21.9		 4tyjA-6c9dA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cnh SERINE/THREONINE-PRO
TEIN KINASE PRP4
HOMOLOG

(Homo sapiens) 		no annotation 6 ALA A 715
GLU A 732
HIS A 813
LEU A 822
ASP A 834
PHE A 835
 919  A1101 (-3.5A)
919  A1101 (-3.7A)
919  A1101 (-4.2A)
None
919  A1101 (-4.5A)
919  A1101 ( 4.1A)
 0.55A 4tyjA-6cnhA:
22.0		 4tyjA-6cnhA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 5 ALA A 756
VAL A 804
ALA A 807
HIS A 872
LEU A 881
 ADN  A1104 (-3.4A)
ADN  A1104 ( 4.6A)
ADN  A1104 (-3.6A)
None
ADN  A1104 (-4.3A)
 0.30A 4tyjA-6fekA:
34.1		 4tyjA-6fekA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 ALA A 191
GLU A 208
ILE A 215
HIS A 288
LEU A 297
ASP A 327
 3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
3NG  A 501 (-4.5A)
 1.19A 4tyjA-6fylA:
22.3		 4tyjA-6fylA:
undetectable