SIMILAR PATTERNS OF AMINO ACIDS FOR 4TXN_C_URFC302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.96A 4txnC-1aogA:
undetectable		 4txnC-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 THR A 360
GLY A 358
ALA A 355
ILE A 290
 None
 0.92A 4txnC-1e1cA:
undetectable		 4txnC-1e1cA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		4 GLY A 196
GLN A 147
ARG A 144
ALA A 137
 None
DCS  A 301 (-4.1A)
None
None
 0.96A 4txnC-1i2lA:
undetectable		 4txnC-1i2lA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 GLY A 174
GLN A 108
ALA A 177
ILE A  89
 None
 0.86A 4txnC-1ii0A:
undetectable		 4txnC-1ii0A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 106
MET A  93
ALA A  66
ILE A  20
 None
 0.83A 4txnC-1iyxA:
undetectable		 4txnC-1iyxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyo PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF09119
(SicP-binding) 		4 THR E  51
GLY E  54
ALA E  38
ILE E  72
 None
 0.90A 4txnC-1jyoE:
undetectable		 4txnC-1jyoE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 THR A 218
GLY A 216
GLN A 189
ILE A 326
 None
 0.93A 4txnC-1kehA:
undetectable		 4txnC-1kehA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Agrobacterium
tumefaciens) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 THR A 129
GLY A  36
ALA A 131
ILE A 110
 LAE  A1003 (-3.8A)
None
None
LAE  A1003 ( 4.3A)
 0.88A 4txnC-1l3lA:
undetectable		 4txnC-1l3lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		4 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.95A 4txnC-1qaxA:
undetectable		 4txnC-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		4 GLY A 207
GLN A  84
ARG A 306
ILE A 305
 None
 0.84A 4txnC-1rdrA:
undetectable		 4txnC-1rdrA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 GLY A 219
MET A 161
ALA A 221
ILE A 227
 None
 0.88A 4txnC-1s1fA:
undetectable		 4txnC-1s1fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 THR A 184
MET A 243
ALA A 144
ILE A 127
 None
 0.96A 4txnC-1w5eA:
4.5		 4txnC-1w5eA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 THR A 491
GLY A 477
ALA A 516
ILE A 533
 None
 0.79A 4txnC-1w6sA:
undetectable		 4txnC-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		4 GLY A  66
GLN A  63
ALA A  70
ILE A 368
 None
 0.74A 4txnC-1x9yA:
undetectable		 4txnC-1x9yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 GLY A 207
GLN A  84
ARG A 305
ILE A 304
 None
 0.94A 4txnC-1xr5A:
undetectable		 4txnC-1xr5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhq MANNAN-BINDING
LECTIN

(Microcystis
viridis) 		PF12151
(MVL) 		4 GLY A  89
GLN A  30
ALA A  85
ILE A 109
 EDO  A1004 ( 4.6A)
None
None
None
 0.92A 4txnC-1zhqA:
undetectable		 4txnC-1zhqA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		4 GLY A 193
GLN A 190
ALA A 197
ILE A  34
 None
 0.71A 4txnC-2czqA:
3.7		 4txnC-2czqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drq XYLANASE Y

(Bacillus
halodurans) 		PF01270
(Glyco_hydro_8) 		4 THR A 326
GLY A 330
ALA A 268
ILE A 291
 None
 0.77A 4txnC-2drqA:
undetectable		 4txnC-2drqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 GLY A  45
ARG A  15
ALA A  43
ILE A  22
 None
 0.62A 4txnC-2ibdA:
undetectable		 4txnC-2ibdA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4v UNCHARACTERIZED
PROTEIN PA1076

(Pseudomonas
aeruginosa) 		PF16703
(DUF5064) 		4 GLY A  80
GLN A  21
ALA A  76
ILE A  25
 None
 0.83A 4txnC-2k4vA:
undetectable		 4txnC-2k4vA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 THR A 220
GLY A 217
ALA A 213
ILE A 186
 None
 0.81A 4txnC-2lbpA:
3.0		 4txnC-2lbpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m38 ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00640
(PID) 		4 THR A 136
GLY A 138
ALA A 140
ILE A  89
 None
 0.88A 4txnC-2m38A:
undetectable		 4txnC-2m38A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noc PUTATIVE PERIPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07338
(DUF1471) 		4 GLY A  83
MET A  49
ALA A  85
ILE A  43
 None
 0.92A 4txnC-2nocA:
undetectable		 4txnC-2nocA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oas 4-HYDROXYBUTYRATE
COENZYME A
TRANSFERASE

(Shewanella
oneidensis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 THR A 136
ARG A 167
ALA A 114
ILE A 146
 None
 0.97A 4txnC-2oasA:
undetectable		 4txnC-2oasA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		4 GLY A1096
GLN A1166
ARG A1168
MET A1197
 None
 0.81A 4txnC-2oxfA:
24.5		 4txnC-2oxfA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pif UPF0317 PROTEIN
PSPTO_5379

(Pseudomonas
syringae group
genomosp. 3) 		PF07286
(DUF1445) 		4 THR A  77
GLY A  82
ARG A  23
ALA A  80
 None
 0.89A 4txnC-2pifA:
undetectable		 4txnC-2pifA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 THR A 173
GLY A 217
GLN A 212
ILE A   9
 None
None
None
FAD  A 600 (-4.6A)
 0.86A 4txnC-2r4jA:
undetectable		 4txnC-2r4jA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8i PUTATIVE OUTER
MEMBRANE LIPOPROTEIN
WZA

(Escherichia
coli) 		PF02563
(Poly_export)
PF10531
(SLBB) 		4 GLY A 297
MET A  55
ALA A 295
ILE A 288
 None
 0.89A 4txnC-2w8iA:
undetectable		 4txnC-2w8iA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wc1 FLAVODOXIN

(Rhodobacter
capsulatus) 		PF00258
(Flavodoxin_1) 		4 GLY A 133
GLN A 157
ARG A 164
ALA A 131
 None
 0.95A 4txnC-2wc1A:
2.1		 4txnC-2wc1A:
25.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 THR A 382
GLY A 380
ALA A 377
ILE A 311
 None
 0.89A 4txnC-2xijA:
undetectable		 4txnC-2xijA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywv PHOSPHORIBOSYLAMINOI
MIDAZOLE
SUCCINOCARBOXAMIDE
SYNTHETASE

(Geobacillus
kaustophilus) 		PF01259
(SAICAR_synt) 		4 GLY A 111
ARG A 173
ALA A  99
ILE A 175
 None
SO4  A 545 (-4.0A)
None
None
 0.95A 4txnC-2ywvA:
undetectable		 4txnC-2ywvA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		4 GLN A 493
MET A 498
ALA A 531
ILE A 596
 None
 0.94A 4txnC-3a24A:
undetectable		 4txnC-3a24A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 4txnC-3bjeA:
23.0		 4txnC-3bjeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 THR A  95
GLY A  52
ALA A  97
ILE A  74
 None
 0.79A 4txnC-3cp2A:
undetectable		 4txnC-3cp2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czb PUTATIVE
TRANSGLYCOSYLASE

(Caulobacter
vibrioides) 		PF03562
(MltA)
PF06725
(3D) 		4 GLY A 247
MET A 252
ALA A 358
ILE A 219
 None
 0.94A 4txnC-3czbA:
undetectable		 4txnC-3czbA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		4 THR A 157
GLY A 143
ALA A 155
ILE A 109
 None
 0.91A 4txnC-3dasA:
undetectable		 4txnC-3dasA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db9 UPF0317 PROTEIN
ATU3911

(Agrobacterium
fabrum) 		PF07286
(DUF1445) 		4 THR A  78
GLY A  83
ARG A  24
ALA A  81
 None
 0.97A 4txnC-3db9A:
undetectable		 4txnC-3db9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 THR A 166
GLY A 164
ALA A 241
ILE A 230
 None
 0.84A 4txnC-3e7fA:
undetectable		 4txnC-3e7fA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00857
(Isochorismatase) 		4 THR A  27
GLY A  29
ALA A  31
ILE A  79
 None
 0.71A 4txnC-3eefA:
undetectable		 4txnC-3eefA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 141
GLY A 143
GLN A 217
ARG A 219
MET A 249
 PO4  A 401 ( 3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 (-3.1A)
BAU  A 400 (-3.0A)
BAU  A 400 (-3.8A)
 0.25A 4txnC-3eufA:
41.6		 4txnC-3eufA:
40.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 THR A  95
GLY A  52
ALA A  97
ILE A  74
 None
 0.77A 4txnC-3g05A:
undetectable		 4txnC-3g05A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		4 THR A 262
GLY A 152
ALA A 150
ILE A 257
 None
 0.96A 4txnC-3h8lA:
undetectable		 4txnC-3h8lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		4 THR A  27
GLY A  41
ALA A  29
ILE A 239
 None
 0.89A 4txnC-3hbcA:
undetectable		 4txnC-3hbcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		4 GLY A 198
ARG A 231
ALA A 202
ILE A 232
 None
 0.90A 4txnC-3hjlA:
undetectable		 4txnC-3hjlA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1c DIISOPROPYL-FLUOROPH
OSPHATASE

(Loligo vulgaris) 		PF08450
(SGL) 		4 THR A 279
GLY A 301
GLN A 304
ILE A 282
 None
 0.93A 4txnC-3i1cA:
undetectable		 4txnC-3i1cA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2d ABC-TYPE METAL ION
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Vibrio
vulnificus) 		PF03180
(Lipoprotein_9) 		4 THR A  71
GLN A  87
ALA A  75
ILE A  81
 None
 0.91A 4txnC-3k2dA:
undetectable		 4txnC-3k2dA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvd LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 THR D 204
GLY D 290
ALA D 271
ILE D 263
 None
 0.85A 4txnC-3kvdD:
undetectable		 4txnC-3kvdD:
24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		6 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.32A 4txnC-3kvyA:
41.8		 4txnC-3kvyA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 THR A 102
GLY A 104
ALA A 106
ILE A  78
 None
 0.84A 4txnC-3l01A:
2.0		 4txnC-3l01A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlp TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF01833
(TIG)
PF16422
(COE1_DBD)
PF16423
(COE1_HLH) 		4 GLY A  46
GLN A  78
ALA A  42
ILE A 120
 None
 0.69A 4txnC-3mlpA:
undetectable		 4txnC-3mlpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 GLY A 331
MET A  27
ALA A 329
ILE A 382
 None
 0.91A 4txnC-3n0lA:
undetectable		 4txnC-3n0lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 131
GLN A 186
MET A 227
ALA A 109
ILE A 127
 None
None
KCX  A 188 ( 4.5A)
None
None
 1.45A 4txnC-3n2cA:
undetectable		 4txnC-3n2cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyi FAT ACID-BINDING
PROTEIN

(Eubacterium
ventriosum) 		PF02645
(DegV) 		4 THR A 182
GLY A 186
ALA A 184
ILE A 206
 None
 0.94A 4txnC-3nyiA:
2.5		 4txnC-3nyiA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 112
MET A  93
ALA A  66
ILE A  21
 None
 0.85A 4txnC-3otrA:
undetectable		 4txnC-3otrA:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 147
GLY A 149
GLN A 223
ARG A 225
MET A 255
 BAU  A 400 (-4.5A)
BAU  A 400 (-3.5A)
BAU  A 400 (-3.1A)
BAU  A 400 (-2.8A)
BAU  A 400 (-3.9A)
 0.31A 4txnC-3p0fA:
39.5		 4txnC-3p0fA:
42.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 GLY A 123
GLN A 256
ALA A 117
ILE A 177
 None
 0.91A 4txnC-3q3uA:
undetectable		 4txnC-3q3uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 GLY A 156
GLN A 199
ARG A 210
ALA A 384
ILE A 385
 None
 1.49A 4txnC-3qp9A:
2.7		 4txnC-3qp9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 105
MET A  92
ALA A  65
ILE A  20
 None
 0.73A 4txnC-3qtpA:
undetectable		 4txnC-3qtpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 THR A 387
GLY A 490
ARG A 557
ALA A 565
 None
 0.96A 4txnC-3ucqA:
undetectable		 4txnC-3ucqA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 THR A 343
GLY A 345
ALA A 347
ILE A 402
 None
 0.92A 4txnC-3w9iA:
undetectable		 4txnC-3w9iA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wia NITRITE REDUCTASE

(Geobacillus
kaustophilus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 THR A  64
GLY A 147
ALA A  62
ILE A  52
 None
 0.95A 4txnC-3wiaA:
undetectable		 4txnC-3wiaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		4 THR A 317
GLN A 268
ARG A 149
ILE A 293
 None
 0.96A 4txnC-3wrtA:
undetectable		 4txnC-3wrtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 THR A  39
GLY A  35
GLN A 258
ARG A 617
 MG  A1663 ( 2.8A)
ANP  A1662 (-3.1A)
ANP  A1662 (-3.2A)
ANP  A1662 (-3.0A)
 0.89A 4txnC-4c30A:
undetectable		 4txnC-4c30A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii) 		PF00267
(Porin_1) 		4 THR A 239
GLN A 152
ALA A 215
ILE A  98
 None
 0.93A 4txnC-4d65A:
undetectable		 4txnC-4d65A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 THR A 206
GLY A 208
ALA A 210
ILE A  41
 None
 0.86A 4txnC-4dalA:
undetectable		 4txnC-4dalA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.95A 4txnC-4fxsA:
undetectable		 4txnC-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 THR A  85
GLY A  89
ARG A 156
ALA A  87
 None
 0.79A 4txnC-4gpgA:
undetectable		 4txnC-4gpgA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		4 THR A 142
GLY A 133
ALA A 131
ILE A  77
 None
 0.95A 4txnC-4gz8A:
undetectable		 4txnC-4gz8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		4 GLY A 407
MET A 328
ALA A 413
ILE A 415
 None
 0.79A 4txnC-4irtA:
undetectable		 4txnC-4irtA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		4 GLY A  54
MET A 178
ALA A  52
ILE A 135
 None
 0.90A 4txnC-4nwzA:
undetectable		 4txnC-4nwzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis) 		no annotation 4 THR A 212
GLY A 189
ARG A 174
ILE A 170
 None
 0.93A 4txnC-4o7pA:
undetectable		 4txnC-4o7pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		4 GLY A  77
GLN A 146
ALA A  81
ILE A  51
 None
 0.93A 4txnC-4ofxA:
undetectable		 4txnC-4ofxA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 273
MET A 172
ALA A 259
ILE A 286
 None
 0.83A 4txnC-4plhA:
2.6		 4txnC-4plhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 200
MET A 207
ALA A 195
ILE A 110
 None
 0.94A 4txnC-4qavA:
undetectable		 4txnC-4qavA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A 402
GLY A 412
ALA A 415
ILE A 307
 None
 0.89A 4txnC-4qg5A:
undetectable		 4txnC-4qg5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 THR A 317
GLY A 276
MET A 273
ILE A  27
 None
 0.81A 4txnC-4qtsA:
undetectable		 4txnC-4qtsA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		5 THR A  91
GLY A  93
GLN A 163
ARG A 165
MET A 194
 SO4  A 302 ( 3.0A)
None
None
None
GOL  A 303 (-3.5A)
 0.31A 4txnC-4r2wA:
24.8		 4txnC-4r2wA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		4 GLY A  94
GLN A 164
ARG A 166
MET A 195
 None
None
None
GOL  A 301 (-4.0A)
 0.66A 4txnC-4r31A:
24.2		 4txnC-4r31A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		4 THR A 464
GLY A 500
ALA A 502
ILE A 523
 None
 0.80A 4txnC-4ru4A:
undetectable		 4txnC-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		4 THR A 404
GLN A 347
ALA A 408
ILE A 267
 None
 0.84A 4txnC-4s1wA:
3.9		 4txnC-4s1wA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 GLN A 365
ARG A  64
ALA A 386
ILE A   4
 None
 0.94A 4txnC-4s3jA:
undetectable		 4txnC-4s3jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xij SHIKIMATE
5-DEHYDROGENASE

(Mycolicibacterium
fortuitum) 		PF08501
(Shikimate_dh_N) 		4 GLY A 115
ARG A 210
ALA A 113
ILE A 235
 None
 0.64A 4txnC-4xijA:
undetectable		 4txnC-4xijA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 THR A 394
GLY A 202
ALA A 198
ILE A 162
 None
 0.60A 4txnC-4xwtA:
undetectable		 4txnC-4xwtA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwx SHC-TRANSFORMING
PROTEIN 1

(Homo sapiens) 		PF00640
(PID) 		4 GLY A 155
GLN A 188
ALA A 153
ILE A 194
 None
 0.95A 4txnC-4xwxA:
undetectable		 4txnC-4xwxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0a SHIKIMATE KINASE

(Acinetobacter
baumannii) 		PF01202
(SKI) 		4 THR A  94
GLY A  96
ALA A  98
ILE A  99
 None
SKM  A 201 (-3.1A)
None
None
 0.88A 4txnC-4y0aA:
undetectable		 4txnC-4y0aA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5

(Saccharomyces
cerevisiae) 		PF00533
(BRCT)
PF16893
(fn3_2) 		4 GLY A 173
GLN A  91
ALA A 201
ILE A 199
 None
 0.85A 4txnC-4yg8A:
undetectable		 4txnC-4yg8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN ALPHA
SUBUNIT

(Palmaria
palmata) 		PF00502
(Phycobilisome) 		4 GLY A 150
GLN A 147
ARG A  33
ALA A 154
 None
 0.86A 4txnC-5b13A:
undetectable		 4txnC-5b13A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 THR A 192
GLN A 175
ALA A 260
ILE A 213
 None
 0.94A 4txnC-5cfaA:
undetectable		 4txnC-5cfaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran)
PF02361
(CbiQ) 		4 GLY A 109
ARG D 233
MET D 222
ALA A 107
 None
 0.93A 4txnC-5d3mA:
undetectable		 4txnC-5d3mA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkr ENDO-1,4-BETA-GLUCAN
ASE/XYLOGLUCANASE,
PUTATIVE, GLY74A

(Cellvibrio
japonicus) 		no annotation 4 THR A  69
GLY A  54
ALA A  67
ILE A 436
 None
 0.95A 4txnC-5fkrA:
undetectable		 4txnC-5fkrA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 GLY A 179
GLN A  60
ALA A 256
ILE A 134
 None
 0.75A 4txnC-5hd2A:
undetectable		 4txnC-5hd2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 THR A  93
GLN A 165
ARG A 167
MET A 196
ILE A 220
 SO4  A 301 ( 2.9A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.40A 4txnC-5lhvA:
25.0		 4txnC-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.36A 4txnC-5lhvA:
25.0		 4txnC-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojy TETR FAMILY
TRANSCRIPTION
REGULATOR

(Streptomyces
alboniger) 		no annotation 4 THR A 167
GLY A 169
ALA A 171
ILE A 122
 None
None
None
GOL  A 302 ( 4.7A)
 0.94A 4txnC-5ojyA:
undetectable		 4txnC-5ojyA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		4 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.91A 4txnC-5uzeA:
undetectable		 4txnC-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		4 GLY A 333
MET A  29
ALA A 331
ILE A 384
 None
 0.81A 4txnC-5vc2A:
undetectable		 4txnC-5vc2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 4 GLY A 437
GLN A 624
ALA A 448
ILE A 435
 None
 0.94A 4txnC-5xioA:
2.5		 4txnC-5xioA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 4 THR A 325
GLY A 378
ALA A 376
ILE A 351
 None
 0.92A 4txnC-6bk7A:
2.4		 4txnC-6bk7A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT C

(Flavobacterium
johnsoniae) 		no annotation 4 THR C 256
GLY C 253
ARG C 337
ILE C 390
 None
 0.96A 4txnC-6btmC:
undetectable		 4txnC-6btmC:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A1385
GLN A1391
ALA A1383
ILE A1371
 None
 0.84A 4txnC-6emkA:
undetectable		 4txnC-6emkA:
13.40