SIMILAR PATTERNS OF AMINO ACIDS FOR 4TXN_A_URFA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 194
GLY A 196
ALA A 285
ILE A 200
 None
MAE  A 500 ( 3.9A)
None
FAD  A 492 ( 4.3A)
 0.95A 4txnA-1aogA:
undetectable		 4txnA-1aogA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 THR A 360
GLY A 358
ALA A 355
ILE A 290
 None
 0.91A 4txnA-1e1cA:
3.3		 4txnA-1e1cA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ey1 ANTITERMINATION
FACTOR NUSB

(Escherichia
coli) 		PF01029
(NusB) 		4 THR A  59
GLY A  54
ALA A  56
ILE A  27
 None
 0.94A 4txnA-1ey1A:
undetectable		 4txnA-1ey1A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		4 GLY A 196
GLN A 147
ARG A 144
ALA A 137
 None
DCS  A 301 (-4.1A)
None
None
 0.95A 4txnA-1i2lA:
undetectable		 4txnA-1i2lA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		4 GLY A 174
GLN A 108
ALA A 177
ILE A  89
 None
 0.86A 4txnA-1ii0A:
undetectable		 4txnA-1ii0A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 106
MET A  93
ALA A  66
ILE A  20
 None
 0.81A 4txnA-1iyxA:
undetectable		 4txnA-1iyxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jyo PROTEIN TYROSINE
PHOSPHATASE SPTP

(Salmonella
enterica) 		PF09119
(SicP-binding) 		4 THR E  51
GLY E  54
ALA E  38
ILE E  72
 None
 0.86A 4txnA-1jyoE:
undetectable		 4txnA-1jyoE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 THR A 218
GLY A 216
GLN A 189
ILE A 326
 None
 0.92A 4txnA-1kehA:
undetectable		 4txnA-1kehA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3l TRANSCRIPTIONAL
ACTIVATOR PROTEIN
TRAR

(Agrobacterium
tumefaciens) 		PF00196
(GerE)
PF03472
(Autoind_bind) 		4 THR A 129
GLY A  36
ALA A 131
ILE A 110
 LAE  A1003 (-3.8A)
None
None
LAE  A1003 ( 4.3A)
 0.82A 4txnA-1l3lA:
undetectable		 4txnA-1l3lA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		4 GLY A 367
GLN A 364
ALA A 371
ILE A 377
 HMG  A1002 (-4.5A)
HMG  A1002 (-4.2A)
HMG  A1002 ( 3.8A)
HMG  A1002 (-4.9A)
 0.93A 4txnA-1qaxA:
undetectable		 4txnA-1qaxA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		4 GLY A 207
GLN A  84
ARG A 306
ILE A 305
 None
 0.83A 4txnA-1rdrA:
undetectable		 4txnA-1rdrA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1f PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 GLY A 219
MET A 161
ALA A 221
ILE A 227
 None
 0.86A 4txnA-1s1fA:
undetectable		 4txnA-1s1fA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 THR A 491
GLY A 477
ALA A 516
ILE A 533
 None
 0.81A 4txnA-1w6sA:
undetectable		 4txnA-1w6sA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		4 GLY A  66
GLN A  63
ALA A  70
ILE A 368
 None
 0.72A 4txnA-1x9yA:
undetectable		 4txnA-1x9yA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		4 GLY A 207
GLN A  84
ARG A 305
ILE A 304
 None
 0.94A 4txnA-1xr5A:
undetectable		 4txnA-1xr5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zhq MANNAN-BINDING
LECTIN

(Microcystis
viridis) 		PF12151
(MVL) 		4 GLY A  89
GLN A  30
ALA A  85
ILE A 109
 EDO  A1004 ( 4.6A)
None
None
None
 0.95A 4txnA-1zhqA:
undetectable		 4txnA-1zhqA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkj EXTENDED-SPECTRUM
BETA-LACTAMASE

(Klebsiella
aerogenes) 		PF00144
(Beta-lactamase) 		4 THR A 313
GLN A 267
ARG A 149
ILE A 292
 None
 0.93A 4txnA-1zkjA:
undetectable		 4txnA-1zkjA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afb 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermotoga
maritima) 		PF00294
(PfkB) 		4 GLY A  33
ARG A 105
ALA A  34
ILE A 135
 None
 0.96A 4txnA-2afbA:
undetectable		 4txnA-2afbA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czq CUTINASE-LIKE
PROTEIN

(Cryptococcus
sp. S-2) 		PF01083
(Cutinase) 		4 GLY A 193
GLN A 190
ALA A 197
ILE A  34
 None
 0.72A 4txnA-2czqA:
2.3		 4txnA-2czqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drq XYLANASE Y

(Bacillus
halodurans) 		PF01270
(Glyco_hydro_8) 		4 THR A 326
GLY A 330
ALA A 268
ILE A 291
 None
 0.72A 4txnA-2drqA:
undetectable		 4txnA-2drqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 GLY A  45
ARG A  15
ALA A  43
ILE A  22
 None
 0.64A 4txnA-2ibdA:
undetectable		 4txnA-2ibdA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4v UNCHARACTERIZED
PROTEIN PA1076

(Pseudomonas
aeruginosa) 		PF16703
(DUF5064) 		4 GLY A  80
GLN A  21
ALA A  76
ILE A  25
 None
 0.85A 4txnA-2k4vA:
undetectable		 4txnA-2k4vA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lbp LEUCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13458
(Peripla_BP_6) 		4 THR A 220
GLY A 217
ALA A 213
ILE A 186
 None
 0.82A 4txnA-2lbpA:
4.8		 4txnA-2lbpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m38 ANKYRIN REPEAT AND
STERILE ALPHA MOTIF
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF00640
(PID) 		4 THR A 136
GLY A 138
ALA A 140
ILE A  89
 None
 0.87A 4txnA-2m38A:
undetectable		 4txnA-2m38A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noc PUTATIVE PERIPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07338
(DUF1471) 		4 GLY A  83
MET A  49
ALA A  85
ILE A  43
 None
 0.94A 4txnA-2nocA:
undetectable		 4txnA-2nocA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		4 GLY A1096
GLN A1166
ARG A1168
MET A1197
 None
 0.77A 4txnA-2oxfA:
24.5		 4txnA-2oxfA:
25.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pif UPF0317 PROTEIN
PSPTO_5379

(Pseudomonas
syringae group
genomosp. 3) 		PF07286
(DUF1445) 		4 THR A  77
GLY A  82
ARG A  23
ALA A  80
 None
 0.88A 4txnA-2pifA:
undetectable		 4txnA-2pifA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 THR A 173
GLY A 217
GLN A 212
ILE A   9
 None
None
None
FAD  A 600 (-4.6A)
 0.87A 4txnA-2r4jA:
undetectable		 4txnA-2r4jA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 THR A 382
GLY A 380
ALA A 377
ILE A 311
 None
 0.87A 4txnA-2xijA:
3.4		 4txnA-2xijA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywv PHOSPHORIBOSYLAMINOI
MIDAZOLE
SUCCINOCARBOXAMIDE
SYNTHETASE

(Geobacillus
kaustophilus) 		PF01259
(SAICAR_synt) 		4 GLY A 111
ARG A 173
ALA A  99
ILE A 175
 None
SO4  A 545 (-4.0A)
None
None
 0.94A 4txnA-2ywvA:
undetectable		 4txnA-2ywvA:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.20A 4txnA-3bjeA:
23.2		 4txnA-3bjeA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp2 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME GIDA

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 THR A  95
GLY A  52
ALA A  97
ILE A  74
 None
 0.85A 4txnA-3cp2A:
undetectable		 4txnA-3cp2A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3das PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF07995
(GSDH) 		4 THR A 157
GLY A 143
ALA A 155
ILE A 109
 None
 0.95A 4txnA-3dasA:
undetectable		 4txnA-3dasA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 THR A 166
GLY A 164
ALA A 241
ILE A 230
 None
 0.77A 4txnA-3e7fA:
undetectable		 4txnA-3e7fA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eef N-CARBAMOYLSARCOSINE
AMIDASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF00857
(Isochorismatase) 		4 THR A  27
GLY A  29
ALA A  31
ILE A  79
 None
 0.72A 4txnA-3eefA:
undetectable		 4txnA-3eefA:
20.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 141
GLY A 143
GLN A 217
ARG A 219
MET A 249
 PO4  A 401 ( 3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 (-3.1A)
BAU  A 400 (-3.0A)
BAU  A 400 (-3.8A)
 0.25A 4txnA-3eufA:
41.4		 4txnA-3eufA:
40.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 THR A  95
GLY A  52
ALA A  97
ILE A  74
 None
 0.84A 4txnA-3g05A:
undetectable		 4txnA-3g05A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		4 GLY A 218
ARG A  48
ALA A 236
ILE A 161
 EDO  A 261 (-3.9A)
EDO  A 261 ( 3.8A)
None
EDO  A 255 (-4.5A)
 0.93A 4txnA-3ggdA:
undetectable		 4txnA-3ggdA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		4 THR A 262
GLY A 152
ALA A 150
ILE A 257
 None
 0.95A 4txnA-3h8lA:
undetectable		 4txnA-3h8lA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbc CHOLOYLGLYCINE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF02275
(CBAH) 		4 THR A  27
GLY A  41
ALA A  29
ILE A 239
 None
 0.84A 4txnA-3hbcA:
undetectable		 4txnA-3hbcA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjl FLAGELLAR MOTOR
SWITCH PROTEIN FLIG

(Aquifex
aeolicus) 		PF01706
(FliG_C)
PF14841
(FliG_M)
PF14842
(FliG_N) 		4 GLY A 198
ARG A 231
ALA A 202
ILE A 232
 None
 0.90A 4txnA-3hjlA:
undetectable		 4txnA-3hjlA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2d ABC-TYPE METAL ION
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Vibrio
vulnificus) 		PF03180
(Lipoprotein_9) 		4 THR A  71
GLN A  87
ALA A  75
ILE A  81
 None
 0.89A 4txnA-3k2dA:
undetectable		 4txnA-3k2dA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvd LIPOPROTEIN

(Neisseria
meningitidis) 		PF08794
(Lipoprot_C) 		4 THR D 204
GLY D 290
ALA D 271
ILE D 263
 None
 0.84A 4txnA-3kvdD:
undetectable		 4txnA-3kvdD:
24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		6 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
 0.33A 4txnA-3kvyA:
41.6		 4txnA-3kvyA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kws PUTATIVE SUGAR
ISOMERASE

(Parabacteroides
distasonis) 		PF01261
(AP_endonuc_2) 		4 THR A 185
GLY A 142
ALA A 138
ILE A 108
 None
 0.95A 4txnA-3kwsA:
undetectable		 4txnA-3kwsA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 THR A 102
GLY A 104
ALA A 106
ILE A  78
 None
 0.84A 4txnA-3l01A:
2.4		 4txnA-3l01A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlp TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF01833
(TIG)
PF16422
(COE1_DBD)
PF16423
(COE1_HLH) 		4 GLY A  46
GLN A  78
ALA A  42
ILE A 120
 None
 0.72A 4txnA-3mlpA:
undetectable		 4txnA-3mlpA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 GLY A 331
MET A  27
ALA A 329
ILE A 382
 None
 0.93A 4txnA-3n0lA:
undetectable		 4txnA-3n0lA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2c PROLIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 GLY A 131
GLN A 186
MET A 227
ALA A 109
ILE A 127
 None
None
KCX  A 188 ( 4.5A)
None
None
 1.44A 4txnA-3n2cA:
undetectable		 4txnA-3n2cA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyi FAT ACID-BINDING
PROTEIN

(Eubacterium
ventriosum) 		PF02645
(DegV) 		4 THR A 182
GLY A 186
ALA A 184
ILE A 206
 None
 0.94A 4txnA-3nyiA:
undetectable		 4txnA-3nyiA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 112
MET A  93
ALA A  66
ILE A  21
 None
 0.86A 4txnA-3otrA:
undetectable		 4txnA-3otrA:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 147
GLY A 149
GLN A 223
ARG A 225
MET A 255
 BAU  A 400 (-4.5A)
BAU  A 400 (-3.5A)
BAU  A 400 (-3.1A)
BAU  A 400 (-2.8A)
BAU  A 400 (-3.9A)
 0.28A 4txnA-3p0fA:
39.5		 4txnA-3p0fA:
42.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 GLY A 123
GLN A 256
ALA A 117
ILE A 177
 None
 0.93A 4txnA-3q3uA:
undetectable		 4txnA-3q3uA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 GLY A 156
GLN A 199
ARG A 210
ALA A 384
ILE A 385
 None
 1.48A 4txnA-3qp9A:
2.2		 4txnA-3qp9A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 105
MET A  92
ALA A  65
ILE A  20
 None
 0.72A 4txnA-3qtpA:
undetectable		 4txnA-3qtpA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 THR A 387
GLY A 490
ARG A 557
ALA A 565
 None
 0.90A 4txnA-3ucqA:
undetectable		 4txnA-3ucqA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2i PEPTIDYL-TRNA
HYDROLASE

(Burkholderia
thailandensis) 		PF01195
(Pept_tRNA_hydro) 		4 THR A  16
GLY A  12
GLN A  64
ALA A  13
 None
 0.95A 4txnA-3v2iA:
8.0		 4txnA-3v2iA:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB

(Pseudomonas
aeruginosa) 		PF00873
(ACR_tran) 		4 THR A 343
GLY A 345
ALA A 347
ILE A 402
 None
 0.95A 4txnA-3w9iA:
undetectable		 4txnA-3w9iA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wia NITRITE REDUCTASE

(Geobacillus
kaustophilus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 THR A  64
GLY A 147
ALA A  62
ILE A  52
 None
 0.94A 4txnA-3wiaA:
undetectable		 4txnA-3wiaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		4 THR A 317
GLN A 268
ARG A 149
ILE A 293
 None
 0.92A 4txnA-3wrtA:
undetectable		 4txnA-3wrtA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		4 THR A 379
GLY A 482
ARG A 554
ALA A 562
 None
 0.92A 4txnA-4aysA:
undetectable		 4txnA-4aysA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 THR A  39
GLY A  35
GLN A 258
ARG A 617
 MG  A1663 ( 2.8A)
ANP  A1662 (-3.1A)
ANP  A1662 (-3.2A)
ANP  A1662 (-3.0A)
 0.92A 4txnA-4c30A:
2.5		 4txnA-4c30A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii) 		PF00267
(Porin_1) 		4 THR A 239
GLN A 152
ALA A 215
ILE A  98
 None
 0.93A 4txnA-4d65A:
undetectable		 4txnA-4d65A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 THR A 206
GLY A 208
ALA A 210
ILE A  41
 None
 0.90A 4txnA-4dalA:
undetectable		 4txnA-4dalA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxs INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Vibrio cholerae) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 THR A  53
GLY A 363
ALA A 367
ILE A 423
 None
IMP  A 701 (-3.7A)
None
None
 0.90A 4txnA-4fxsA:
undetectable		 4txnA-4fxsA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 THR A  85
GLY A  89
ARG A 156
ALA A  87
 None
 0.77A 4txnA-4gpgA:
undetectable		 4txnA-4gpgA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		4 THR A 142
GLY A 133
ALA A 131
ILE A  77
 None
 0.95A 4txnA-4gz8A:
undetectable		 4txnA-4gz8A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irt UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF15892
(BNR_4) 		4 GLY A 407
MET A 328
ALA A 413
ILE A 415
 None
 0.83A 4txnA-4irtA:
undetectable		 4txnA-4irtA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz5 GP26

(Listeria phage
P40) 		PF01183
(Glyco_hydro_25) 		4 GLY A  18
MET A  53
ALA A 181
ILE A 179
 None
 0.91A 4txnA-4jz5A:
undetectable		 4txnA-4jz5A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbx UNCHARACTERIZED
PROTEIN YHFX

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		5 GLY A 256
GLN A 353
ARG A 351
ALA A 258
ILE A 263
 LLP  A  61 ( 3.4A)
LLP  A  61 (-3.7A)
LLP  A  61 (-3.3A)
None
None
 1.49A 4txnA-4kbxA:
undetectable		 4txnA-4kbxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nwz FAD-DEPENDENT
PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE

(Caldalkalibacillus
thermarum) 		PF07992
(Pyr_redox_2) 		4 GLY A  54
MET A 178
ALA A  52
ILE A 135
 None
 0.87A 4txnA-4nwzA:
undetectable		 4txnA-4nwzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4x TBPB

(Glaesserella
parasuis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 THR A  72
GLY A  48
ARG A 230
ALA A  70
 SO4  A 607 (-3.2A)
None
None
None
 0.91A 4txnA-4o4xA:
undetectable		 4txnA-4o4xA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7p MALTOKINASE

(Mycobacterium
tuberculosis) 		no annotation 4 THR A 212
GLY A 189
ARG A 174
ILE A 170
 None
 0.90A 4txnA-4o7pA:
undetectable		 4txnA-4o7pA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		4 GLY A  77
GLN A 146
ALA A  81
ILE A  51
 None
 0.91A 4txnA-4ofxA:
undetectable		 4txnA-4ofxA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plh MALATE DEHYDROGENASE

(Apicomplexa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 GLY A 273
MET A 172
ALA A 259
ILE A 286
 None
 0.84A 4txnA-4plhA:
2.6		 4txnA-4plhA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qav 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Neisseria
meningitidis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLY A 200
MET A 207
ALA A 195
ILE A 110
 None
 0.95A 4txnA-4qavA:
undetectable		 4txnA-4qavA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A 402
GLY A 412
ALA A 415
ILE A 307
 None
 0.85A 4txnA-4qg5A:
undetectable		 4txnA-4qg5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 THR A 317
GLY A 276
MET A 273
ILE A  27
 None
 0.80A 4txnA-4qtsA:
undetectable		 4txnA-4qtsA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		5 THR A  91
GLY A  93
GLN A 163
ARG A 165
MET A 194
 SO4  A 302 ( 3.0A)
None
None
None
GOL  A 303 (-3.5A)
 0.31A 4txnA-4r2wA:
24.8		 4txnA-4r2wA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		4 GLY A  94
GLN A 164
ARG A 166
MET A 195
 None
None
None
GOL  A 301 (-4.0A)
 0.64A 4txnA-4r31A:
24.3		 4txnA-4r31A:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru4 TAIL SPIKE PROTEIN
GP49

(Pseudomonas
virus LKA1) 		PF13229
(Beta_helix) 		4 THR A 464
GLY A 500
ALA A 502
ILE A 523
 None
 0.74A 4txnA-4ru4A:
undetectable		 4txnA-4ru4A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1w GLUTAMINE--FRUCTOSE-
6-PHOSPHATE
AMINOTRANSFERASE
[ISOMERIZING]

(Staphylococcus
aureus) 		PF01380
(SIS) 		4 THR A 404
GLN A 347
ALA A 408
ILE A 267
 None
 0.91A 4txnA-4s1wA:
3.5		 4txnA-4s1wA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		4 GLN A 365
ARG A  64
ALA A 386
ILE A   4
 None
 0.95A 4txnA-4s3jA:
undetectable		 4txnA-4s3jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 THR A 418
GLY A 375
ALA A 379
ILE A 380
 None
 0.95A 4txnA-4xgjA:
2.1		 4txnA-4xgjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xij SHIKIMATE
5-DEHYDROGENASE

(Mycolicibacterium
fortuitum) 		PF08501
(Shikimate_dh_N) 		4 GLY A 115
ARG A 210
ALA A 113
ILE A 235
 None
 0.65A 4txnA-4xijA:
2.7		 4txnA-4xijA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		4 THR A 394
GLY A 202
ALA A 198
ILE A 162
 None
 0.58A 4txnA-4xwtA:
2.7		 4txnA-4xwtA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwx SHC-TRANSFORMING
PROTEIN 1

(Homo sapiens) 		PF00640
(PID) 		4 GLY A 155
GLN A 188
ALA A 153
ILE A 194
 None
 0.95A 4txnA-4xwxA:
undetectable		 4txnA-4xwxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0a SHIKIMATE KINASE

(Acinetobacter
baumannii) 		PF01202
(SKI) 		4 THR A  94
GLY A  96
ALA A  98
ILE A  99
 None
SKM  A 201 (-3.1A)
None
None
 0.90A 4txnA-4y0aA:
undetectable		 4txnA-4y0aA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5

(Saccharomyces
cerevisiae) 		PF00533
(BRCT)
PF16893
(fn3_2) 		4 GLY A 173
GLN A  91
ALA A 201
ILE A 199
 None
 0.83A 4txnA-4yg8A:
undetectable		 4txnA-4yg8A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a24 DIONAIN-1

(Dionaea
muscipula) 		PF00112
(Peptidase_C1) 		4 GLY A 171
MET A 201
ALA A 131
ILE A 136
 None
 0.94A 4txnA-5a24A:
undetectable		 4txnA-5a24A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b13 PHYCOERYTHRIN ALPHA
SUBUNIT

(Palmaria
palmata) 		PF00502
(Phycobilisome) 		4 GLY A 150
GLN A 147
ARG A  33
ALA A 154
 None
 0.87A 4txnA-5b13A:
undetectable		 4txnA-5b13A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 THR A 192
GLN A 175
ALA A 260
ILE A 213
 None
 0.94A 4txnA-5cfaA:
undetectable		 4txnA-5cfaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 GLY A 179
GLN A  60
ALA A 256
ILE A 134
 None
 0.72A 4txnA-5hd2A:
undetectable		 4txnA-5hd2A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 THR A  93
GLN A 165
ARG A 167
MET A 196
ILE A 220
 SO4  A 301 ( 2.9A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.39A 4txnA-5lhvA:
25.0		 4txnA-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.36A 4txnA-5lhvA:
25.0		 4txnA-5lhvA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		4 THR A  51
GLY A 359
ALA A 363
ILE A 417
 None
IMP  A 500 (-3.5A)
None
None
 0.87A 4txnA-5uzeA:
undetectable		 4txnA-5uzeA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc2 SERINE
HYDROXYMETHYLTRANSFE
RASE

(Helicobacter
pylori) 		PF00464
(SHMT) 		4 GLY A 333
MET A  29
ALA A 331
ILE A 384
 None
 0.83A 4txnA-5vc2A:
undetectable		 4txnA-5vc2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xio PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE)

(Cryptosporidium
parvum) 		no annotation 4 GLY A 437
GLN A 624
ALA A 448
ILE A 435
 None
 0.94A 4txnA-5xioA:
3.2		 4txnA-5xioA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk7 ELONGATION FACTOR G

(Enterococcus
faecalis) 		no annotation 4 THR A 325
GLY A 378
ALA A 376
ILE A 351
 None
 0.93A 4txnA-6bk7A:
undetectable		 4txnA-6bk7A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A1385
GLN A1391
ALA A1383
ILE A1371
 None
 0.82A 4txnA-6emkA:
undetectable		 4txnA-6emkA:
13.40